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Exposure to a high-fat diet compromises gut health, behavior, and HPA axis function, with partial reversal when limited to adolescence.
Ott, Alexandra ORCID: https://orcid.org/0009-0000-4444-1834, Gül, Asude Zülal, Löber, Ulrike ORCID: https://orcid.org/0000-0001-7468-9531, Birkner, Till ORCID: https://orcid.org/0000-0003-2656-2821, Popova, Elena ORCID: https://orcid.org/0000-0002-3043-9650, Winter, Christine and Hadar, Ravit
Brain Research Bulletin 239 : 111883. 1 June 2026

Accelerating Leigh syndrome drug discovery through deep learning screening in brain organoids.
Menacho, Carmen ORCID: https://orcid.org/0000-0001-9754-6322, Okawa, Satoshi, Álvarez-Merz, Iris ORCID: https://orcid.org/0000-0002-2585-1093, Wittich, Annika, Muñoz-Oreja, Mikel, Lisowski, Pawel ORCID: https://orcid.org/0000-0002-3634-1072, Martín, Mario López, Pentimalli, Tancredi Massimo ORCID: https://orcid.org/0000-0002-8461-7918, Zakin, Shiri, Thevandavakkam, Mathuravani, Jerred, Caleb, Lickfett, Selene ORCID: https://orcid.org/0000-0002-3726-9551, Petersilie, Laura, Rybak-Wolf, Agnieszka ORCID: https://orcid.org/0000-0002-1192-5290, Seibt, Annette, Herebian, Diran, Inak, Gizem, Brodesser, Susanne ORCID: https://orcid.org/0000-0001-5631-0663, Zaliani, Andrea ORCID: https://orcid.org/0000-0002-1740-8390, Mlody, Barbara ORCID: https://orcid.org/0000-0001-5184-1772, Donnelly, Justin, Woleben, Kasey, Soriano, Francesc Xavier ORCID: https://orcid.org/0000-0003-1678-7162, Fernandez-Checa, Jose C., Ventura, Natascia ORCID: https://orcid.org/0000-0001-8718-4321, Cambridge, Sidney, Mayatepek, Ertan ORCID: https://orcid.org/0000-0001-8460-3738, Spinazzola, Antonella ORCID: https://orcid.org/0000-0003-4242-8091, Schuelke, Markus ORCID: https://orcid.org/0000-0003-2824-3891, Rajewsky, Nikolaus ORCID: https://orcid.org/0000-0002-4785-4332, Rossi, Andrea ORCID: https://orcid.org/0000-0001-5863-6448, Peralvarez-Marin, Alex ORCID: https://orcid.org/0000-0002-3457-0875, Distelmaier, Felix ORCID: https://orcid.org/0000-0003-4304-7848, Perlstein, Ethan, Holt, Ian J., Puighermanal, Emma ORCID: https://orcid.org/0000-0003-4271-9104, Pless, Ole ORCID: https://orcid.org/0000-0002-1468-316X, Rose, Christine R. ORCID: https://orcid.org/0000-0002-9684-3592, Del Sol, Antonio ORCID: https://orcid.org/0000-0002-9926-617X and Prigione, Alessandro ORCID: https://orcid.org/0000-0001-9457-1952
Nature Communications 17 (1): 3570. 20 April 2026

Chromatin spatial analysis by METALoci unveils sex-determining 3D regulatory hubs.
Mota-Gómez, Irene ORCID: https://orcid.org/0000-0001-8308-8017, Rodríguez, Juan Antonio, Dupont, Shannon, Hurtado, Alicia ORCID: https://orcid.org/0000-0001-6267-704X, Cadenas, Vanessa, Zuber, Leo, Maceda, Iago, Lao, Oscar, Jedamzick, Johanna, Kühn, Ralf ORCID: https://orcid.org/0000-0003-1694-9803, Lacadie, Scott ORCID: https://orcid.org/0000-0002-0893-5340, García-Moreno, Sara Alexander, Torres, Miguel, Real, Francisca M. ORCID: https://orcid.org/0000-0003-0692-2260, Acemel, Rafael D., Capel, Blanche, Marti-Renom, Marc A. and Lupíañez, Dario G. ORCID: https://orcid.org/0000-0002-3165-036X
Nature Structural & Molecular Biology 33 (4): 577-589. April 2026

Personalized CRISPR knock-in cytokine gene therapy to remodel the tumor microenvironment and enhance CAR T cell therapy in solid tumors.
Launspach, Michael ORCID: https://orcid.org/0000-0001-5337-5605, Macos, Julia ORCID: https://orcid.org/0009-0008-9196-3975, Afzal, Shoaib ORCID: https://orcid.org/0009-0009-5490-6098, Hohmann, Janik ORCID: https://orcid.org/0009-0001-5374-1350, Appis, Marc L. ORCID: https://orcid.org/0000-0002-0155-1918, Pilgram, Maximilian ORCID: https://orcid.org/0009-0002-3423-5249, Beez, Stefanie, Ohlendorf, Emily, van der Ven, Casper F.T. ORCID: https://orcid.org/0000-0001-7947-6105, Lachiheb, Chahrazad, Töws, Karin, Andersch, Lena, Jens, Marvin ORCID: https://orcid.org/0000-0002-6660-8743, Zirngibl, Felix ORCID: https://orcid.org/0000-0003-1764-4841, Kath, Jonas ORCID: https://orcid.org/0000-0001-7721-7978, Stecklum, Maria ORCID: https://orcid.org/0009-0001-7951-5730, Rodriguez-Fos, Elias ORCID: https://orcid.org/0000-0002-2555-0178, Anders, Kathleen ORCID: https://orcid.org/0000-0002-0429-200X, Wagner, Dimitrios L. ORCID: https://orcid.org/0000-0002-2189-3579, Henssen, Anton G. ORCID: https://orcid.org/0000-0003-1534-778X, Kühn, Ralf ORCID: https://orcid.org/0000-0003-1694-9803, Eggert, Angelika and Künkele, Annette ORCID: https://orcid.org/0000-0002-8406-5412
Nature Communications 16 (1): 10987. 9 December 2025

Prime editing corrects the dilated cardiomyopathy causing RBM20-P633L-mutation in human cardiomyocytes.
Roman, Alexandra ORCID: https://orcid.org/0000-0001-9440-9752, Zimmer, Anja, Gotthardt, Michael ORCID: https://orcid.org/0000-0003-1788-3172, Steinmetz, Lars M., Kühn, Ralf ORCID: https://orcid.org/0000-0003-1694-9803 and Dang, Tu ORCID: https://orcid.org/0009-0001-0138-7599
Molecular Therapy Nucleic Acids 36 (4): 102734. 9 December 2025

Mice with a diverse human T cell receptor repertoire selected on multiple HLA class I molecules.
Dhamodaran, A. ORCID: https://orcid.org/0000-0001-7711-9593, Chen, X. ORCID: https://orcid.org/0000-0002-5614-1406, Fellmer, N., Agrawal, D., Danner, E., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803 and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Nature Communications 16 (1): 5432. 1 July 2025

Gene-editing in patient and humanized-mice primary muscle stem cells rescues dysferlin expression in dysferlin-deficient muscular dystrophy.
Escobar, H. ORCID: https://orcid.org/0000-0002-8128-7845, Di Francescantonio, S. ORCID: https://orcid.org/0000-0002-4815-491X, Smirnova, J., Graf, R. ORCID: https://orcid.org/0000-0002-5400-9938, Müthel, S. ORCID: https://orcid.org/0000-0002-3525-8859, Marg, A. ORCID: https://orcid.org/0000-0003-3673-4244, Zhogov, A. ORCID: https://orcid.org/0009-0009-2192-0475, Krishna, S. ORCID: https://orcid.org/0009-0008-8974-0721, Metzler, E. ORCID: https://orcid.org/0000-0003-1735-6364, Petkova, M., Daumke, O. ORCID: https://orcid.org/0000-0002-6190-1414, Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803 and Spuler, S. ORCID: https://orcid.org/0000-0002-0155-1117
Nature Communications 16 (1): 120. 2 January 2025

Hyperphenylalaninemia and serotonin deficiency in Dnajc12-deficient mice.
Cao, Y. ORCID: https://orcid.org/0000-0003-0440-3977, Popp, O. ORCID: https://orcid.org/0000-0001-6240-4666, Milani, N. ORCID: https://orcid.org/0000-0001-7510-7986, Qadri, F. ORCID: https://orcid.org/0000-0002-8500-489X, Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Mertins, P. ORCID: https://orcid.org/0000-0002-2245-528X, Bader, M. ORCID: https://orcid.org/0000-0003-4780-4164 and Alenina, N. ORCID: https://orcid.org/0000-0002-6071-5433
Communications Biology 7 (1): 1641. 18 December 2024

Expansion and precise CRISPR-Cas9 gene repair of autologous T memory stem cells from patients with T cell immunodeficiencies.
Li, X. ORCID: https://orcid.org/0000-0002-1173-1066, Chu, V.T. ORCID: https://orcid.org/0000-0003-1327-8696, Kocks, C. ORCID: https://orcid.org/0000-0003-1749-3334 and Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
Bio-protocol 14 (20): e5085. 20 October 2024

In vivo CRISPR/Cas9-mediated screen reveals a critical function of TFDP1 and E2F4 transcription factors in hematopoiesis.
Tran, N.T. ORCID: https://orcid.org/0000-0003-0896-8641, Graf, R. ORCID: https://orcid.org/0000-0002-5400-9938, Acevedo-Ochoa, E. ORCID: https://orcid.org/0000-0001-6466-0073, Trombke, J. ORCID: https://orcid.org/0000-0002-8746-1795, Weber, T. ORCID: https://orcid.org/0000-0003-2079-842X, Sommermann, T. ORCID: https://orcid.org/0000-0003-2899-0256, Salomon, C. ORCID: https://orcid.org/0009-0000-6723-6497, Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Chu, V.T. ORCID: https://orcid.org/0000-0003-1327-8696
Leukemia 38 (9): 2003-2015. September 2024

Mutant huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure.
Lisowski, P. ORCID: https://orcid.org/0000-0002-3634-1072, Lickfett, S. ORCID: https://orcid.org/0000-0002-3726-9551, Rybak-Wolf, A. ORCID: https://orcid.org/0000-0002-1192-5290, Menacho, C. ORCID: https://orcid.org/0000-0001-9754-6322, Le, S. ORCID: https://orcid.org/0000-0002-7500-1759, Pentimalli, T.M. ORCID: https://orcid.org/0000-0002-8461-7918, Notopoulou, S., Dykstra, W. ORCID: https://orcid.org/0000-0002-7663-4689, Oehler, D. ORCID: https://orcid.org/0000-0002-0435-4119, López-Calcerrada, S., Mlody, B. ORCID: https://orcid.org/0000-0001-5184-1772, Otto, M. ORCID: https://orcid.org/0009-0003-1919-5880, Wu, H., Richter, Y., Roth, P. ORCID: https://orcid.org/0009-0006-8642-2993, Anand, R. ORCID: https://orcid.org/0000-0001-7337-6007, Kulka, L.A.M. ORCID: https://orcid.org/0009-0001-3640-3886, Meierhofer, D. ORCID: https://orcid.org/0000-0002-0170-868X, Glazar, P. ORCID: https://orcid.org/0000-0003-0842-0088, Legnini, I. ORCID: https://orcid.org/0000-0002-8984-5215, Telugu, N.S. ORCID: https://orcid.org/0000-0003-4509-7056, Hahn, T., Neuendorf, N., Miller, D.C. ORCID: https://orcid.org/0000-0001-9852-677X, Böddrich, A. ORCID: https://orcid.org/0000-0001-9118-050X, Polzin, A., Mayatepek, E. ORCID: https://orcid.org/0000-0001-8460-3738, Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Olzscha, H. ORCID: https://orcid.org/0000-0002-1929-1384, Kirstein, J. ORCID: https://orcid.org/0000-0003-4990-2497, Ugalde, C. ORCID: https://orcid.org/0000-0002-9742-1877, Petrakis, S. ORCID: https://orcid.org/0000-0001-9094-3480, Cambridge, S., Rajewsky, N. ORCID: https://orcid.org/0000-0002-4785-4332, Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Wanker, E.E. ORCID: https://orcid.org/0000-0001-8072-1630, Priller, J. ORCID: https://orcid.org/0000-0001-7596-0979, Metzger, J.J. ORCID: https://orcid.org/0000-0001-6813-4425 and Prigione, A. ORCID: https://orcid.org/0000-0001-9457-1952
Nature Communications 15 (1): 7027. 22 August 2024

A mouse model of X-linked chronic granulomatous disease for the development of CRISPR/Cas9 gene therapy.
Sevim-Wunderlich, S. ORCID: https://orcid.org/0009-0008-2771-4149, Dang, T. ORCID: https://orcid.org/0009-0001-0138-7599, Rossius, J. ORCID: https://orcid.org/0009-0000-6011-9714, Schnütgen, F. ORCID: https://orcid.org/0000-0002-2426-6685 and Kuehn, R. ORCID: https://orcid.org/0000-0003-1694-9803
Genes 15 (6): 706. June 2024

The C-terminus of the prototypical M2 muscarinic receptor localizes to the mitochondria and regulates cell respiration under stress conditions.
Fasciani, I., Petragnano, F., Wang, Z. ORCID: https://orcid.org/0009-0000-0062-7119, Edwards, R., Telugu, N. ORCID: https://orcid.org/0000-0003-4509-7056, Pietrantoni, I., Zabel, U., Zauber, H. ORCID: https://orcid.org/0000-0003-2595-1147, Grieben, M., Terzenidou, M.E., Di Gregorio, J., Pellegrini, C., Santini, S., Taddei, A.R., Pohl, B., Aringhieri, S., Carli, M., Aloisi, G., Marampon, F., Charlesworth, E., Roman, A. ORCID: https://orcid.org/0000-0001-9440-9752, Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Flati, V., Giorgi, F., Amicarelli, F., Tobin, A.B., Scarselli, M., Tokatlidis, K., Rossi, M., Lohse, M.J. ORCID: https://orcid.org/0000-0002-0599-3510, Annibale, P. ORCID: https://orcid.org/0000-0003-3208-5347 and Maggio, R. ORCID: https://orcid.org/0000-0003-4436-2356
PLoS Biology 22 (4): e3002582. 29 April 2024

Precise CRISPR-Cas9 gene repair in autologous memory T cells to treat familial hemophagocytic lymphohistiocytosis.
Li, X. ORCID: https://orcid.org/0000-0002-1173-1066, Wirtz, T. ORCID: https://orcid.org/0009-0005-5677-9804, Weber, T. ORCID: https://orcid.org/0000-0003-2079-842X, Lebedin, M. ORCID: https://orcid.org/0000-0002-3877-7195, Lowenstein, E.D. ORCID: https://orcid.org/0000-0003-3755-0818, Sommermann, T. ORCID: https://orcid.org/0000-0003-2899-0256, Zach, A., Yasuda, T. ORCID: https://orcid.org/0000-0001-9997-6852, de la Rosa, K. ORCID: https://orcid.org/0000-0003-4809-3157, Chu, V.T. ORCID: https://orcid.org/0000-0003-1327-8696, Schulte, J.H. ORCID: https://orcid.org/0000-0003-0671-1201, Müller, I. ORCID: https://orcid.org/0000-0002-7477-6632, Kocks, C. ORCID: https://orcid.org/0000-0003-1749-3334 and Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
Science Immunology 9 (92): eadi0042. 2 February 2024

A type 1 immunity-restricted promoter of the IL-33 receptor gene directs antiviral T-cell responses.
Brunner, T.M. ORCID: https://orcid.org/0000-0002-5279-2391, Serve, S. ORCID: https://orcid.org/0000-0002-9839-7119, Marx, A.F., Fadejeva, J., Saikali, P. ORCID: https://orcid.org/0000-0002-4916-7376, Dzamukova, M. ORCID: https://orcid.org/0000-0002-2389-3222, Durán-Hernández, N. ORCID: https://orcid.org/0000-0003-4253-0387, Kommer, C., Heinrich, F. ORCID: https://orcid.org/0000-0001-6097-5422, Durek, P., Heinz, G.A. ORCID: https://orcid.org/0000-0002-9330-3689, Höfer, T. ORCID: https://orcid.org/0000-0003-3560-8780, Mashreghi, M.F. ORCID: https://orcid.org/0000-0002-8015-6907, Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Pinschewer, D.D. ORCID: https://orcid.org/0000-0002-1594-3189 and Löhning, M. ORCID: https://orcid.org/0000-0001-6382-7281
Nature Immunology 25 (2): 256-267. February 2024

Human induced pluripotent stem cell-derived pericytes as scalable and editable source to study direct lineage reprogramming into induced neurons.
Menon, R., Petrucci, L., Lohrer, B., Zhang, J., Schulze, M., Schichor, C., Winner, B., Winkler, J., Riemenschneider, M.J., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Falk, S. and Karow, M. ORCID: https://orcid.org/0000-0003-4935-1365
Cellular Reprogramming 25 (5): 212-223. 13 October 2023

Prox2 and Runx3 vagal sensory neurons regulate esophageal motility.
Lowenstein, E.D. ORCID: https://orcid.org/0000-0003-3755-0818, Ruffault, P.L. ORCID: https://orcid.org/0000-0002-3378-3828, Misios, A., Osman, K.L., Li, H., Greenberg, R.S., Thompson, R., Song, K. ORCID: https://orcid.org/0000-0001-6216-8157, Dietrich, S. ORCID: https://orcid.org/0000-0002-0753-9266, Li, X. ORCID: https://orcid.org/0000-0002-1173-1066, Vladimirov, N. ORCID: https://orcid.org/0000-0002-1159-0689, Woehler, A. ORCID: https://orcid.org/0000-0001-5157-9313, Brunet, J.F., Zampieri, N. ORCID: https://orcid.org/0000-0002-2228-9453, Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Liberles, S.D., Jia, S., Lewin, G.R. ORCID: https://orcid.org/0000-0002-2890-6352, Rajewsky, N. ORCID: https://orcid.org/0000-0002-4785-4332, Lever, T.E. and Birchmeier, C. ORCID: https://orcid.org/0000-0002-2041-8872
Neuron 111 (14): 2184-2200.e7. 19 July 2023

The methylation inhibitor 3DZNep promotes HDR pathway choice during CRISPR-Cas9 genome editing.
Bischoff, N., Wimberger, S., Kuehn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Laugesen, A., Turan, V., Larsen, B.D., Sørensen, C.S., Helin, K., Bennett, E.P., Maresca, M. and Brakebusch, C.
Gene and Genome Editing 5 : 100023. June 2023

Application of a spacer-nick gene-targeting approach to repair disease-causing mutations with increased safety.
Tran, N.T. ORCID: https://orcid.org/0000-0003-0896-8641, Lebedin, M. ORCID: https://orcid.org/0000-0002-3877-7195, Danner, E. ORCID: https://orcid.org/0000-0003-3277-5727, Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Chu, V.T. ORCID: https://orcid.org/0000-0003-1327-8696
Bio-protocol 13 (8): e4661. 20 April 2023

Branch point strength controls species-specific CAMK2B alternative splicing and regulates LTP.
Franz, A. ORCID: https://orcid.org/0000-0003-0562-6451, Weber, A.I. ORCID: https://orcid.org/0000-0001-5103-6060, Preußner, M. ORCID: https://orcid.org/0000-0001-5155-0844, Dimos, N. ORCID: https://orcid.org/0000-0001-5398-7310, Stumpf, A. ORCID: https://orcid.org/0000-0002-1510-6970, Ji, Y., Moreno-Velasquez, L. ORCID: https://orcid.org/0000-0001-9735-0039, Voigt, A., Schulz, F. ORCID: https://orcid.org/0000-0002-7756-0562, Neumann, A., Kuropka, B. ORCID: https://orcid.org/0000-0001-5088-6346, Kuehn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Urlaub, H., Schmitz, D. ORCID: https://orcid.org/0000-0003-2741-5241, Wahl, M.C. ORCID: https://orcid.org/0000-0002-2811-5307 and Heyd, F. ORCID: https://orcid.org/0000-0001-9377-9882
Life Science Alliance 6 (3): e202201826. March 2023

IFNγ binding to extracellular matrix prevents fatal systemic toxicity.
Kemna, J. ORCID: https://orcid.org/0000-0002-2172-4441, Gout, E. ORCID: https://orcid.org/0000-0002-5424-6474, Daniau, L., Lao, J., Weißert, K. ORCID: https://orcid.org/0000-0002-9850-6039, Ammann, S. ORCID: https://orcid.org/0000-0003-0385-1890, Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Richter, M. ORCID: https://orcid.org/0000-0002-5339-0781, Molenda, C. ORCID: https://orcid.org/0000-0003-0771-405X, Sporbert, A. ORCID: https://orcid.org/0000-0002-3738-1295, Zocholl, D. ORCID: https://orcid.org/0000-0002-9218-6919, Klopfleisch, R., Schütz, A. ORCID: https://orcid.org/0000-0002-0606-2574, Lortat-Jacob, H. ORCID: https://orcid.org/0000-0002-9772-0762, Aichele, P. ORCID: https://orcid.org/0000-0002-0891-9877, Kammertoens, T. ORCID: https://orcid.org/0000-0003-3309-5141 and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Nature Immunology 24 (3): 414-422. March 2023

Genome-wide screening reveals the genetic basis of mammalian embryonic eye development.
Chee, J.M., Lanoue, L., Clary, D., Higgins, K., Bower, L., Flenniken, A., Guo, R., Adams, D.J., Bosch, F., Braun, R.E., Brown, S.D.M., Chin, H.J.G., Dickinson, M.E., Hsu, C.W., Dobbie, M., Gao, X., Galande, S., Grobler, A., Heaney, J.D., Herault, Y., de Angelis, M.H., Mammano, F., Nutter, L.M.J, Parkinson, H., Qin, C., Shiroishi, T., Sedlacek, R., Seong, J.K., Xu, Y., Brooks, B., McKerlie, C., Lloyd, K.C.K., Westerberg, H. and Moshiri, A.
BMC Biology 21 (1): 22. 3 February 2023

A CRISPR/Cas9-mediated screen identifies determinants of early plasma cell differentiation.
Xiong, E. ORCID: https://orcid.org/0000-0001-5124-6922, Popp, O. ORCID: https://orcid.org/0000-0001-6240-4666, Salomon, C. ORCID: https://orcid.org/0009-0000-6723-6497, Mertins, P. ORCID: https://orcid.org/0000-0002-2245-528X, Kocks, C. ORCID: https://orcid.org/0000-0003-1749-3334, Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Chu, V.T. ORCID: https://orcid.org/0000-0003-1327-8696
Frontiers in Immunology 13 : 1083119. 5 January 2023

Gene editing in mouse zygotes using the CRISPR/Cas9 system.
Wefers, B., Wurst, W. and Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803
Methods in Molecular Biology 2631 : 207-230. 2023

A deletion containing a CTCF-element in intron 8 of the Bbs7 gene is partially responsible for juvenile obesity in the Berlin Fat Mouse.
Krause, F., Mohebian, K. ORCID: https://orcid.org/0000-0002-7337-5132, Delpero, M., Hesse, D. ORCID: https://orcid.org/0000-0001-5915-8003, Kuehn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Arends, D. ORCID: https://orcid.org/0000-0001-8738-0162 and Brockmann, G.A. ORCID: https://orcid.org/0000-0002-4387-2947
Mammalian Genome 33 (3): 465–470. September 2022

A RAS-independent biomarker panel to reliably predict response to MEK inhibition in colorectal cancer.
Pfohl, U., Loskutov, J., Bashir, S. ORCID: https://orcid.org/0000-0002-1281-8710, Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Herter, P. ORCID: https://orcid.org/0000-0002-2340-2171, Templin, M., Mamlouk, S. ORCID: https://orcid.org/0000-0001-7285-1320, Belanov, S. ORCID: https://orcid.org/0000-0003-3419-3659, Linnebacher, M. ORCID: https://orcid.org/0000-0001-8054-1402, Bürtin, F., Vetter, M., Reinhard, C., Wedeken, L. ORCID: https://orcid.org/0000-0003-1061-9459 and Regenbrecht, C.R.A. ORCID: https://orcid.org/0000-0001-9494-5977
Cancers 14 (13): 3252. 1 July 2022

In vivo dissection of a clustered-CTCF domain boundary reveals developmental principles of regulatory insulation.
Anania, C. ORCID: https://orcid.org/0000-0003-1549-4157, Acemel, R.D. ORCID: https://orcid.org/0000-0003-4120-0140, Jedamzick, J., Bolondi, A. ORCID: https://orcid.org/0000-0002-1096-9435, Cova, G., Brieske, N., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Wittler, L., Real, F.M. ORCID: https://orcid.org/0000-0003-0692-2260 and Lupiáñez, D.G. ORCID: https://orcid.org/0000-0002-3165-036X
Nature Genetics 54 (7): 1026-1036. July 2022

Precise CRISPR/Cas-mediated gene repair with minimal off-target and unintended on-target mutations in human hematopoietic stem cells.
Tran, N.T. ORCID: https://orcid.org/0000-0003-0896-8641, Danner, E. ORCID: https://orcid.org/0000-0003-3277-5727, Li, X. ORCID: https://orcid.org/0000-0002-1173-1066, Graf, R. ORCID: https://orcid.org/0000-0002-5400-9938, Lebedin, M. ORCID: https://orcid.org/0000-0002-3877-7195, de la Rosa, K. ORCID: https://orcid.org/0000-0003-4809-3157, Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Chu, V.T. ORCID: https://orcid.org/0000-0003-1327-8696
Science Advances 8 (22): eabm9106. 3 June 2022

Mechanical forces couple bone matrix mineralization with inhibition of angiogenesis to limit adolescent bone growth.
Dzamukova, M. ORCID: https://orcid.org/0000-0002-2389-3222, Brunner, T.M., Miotla-Zarebska, J., Heinrich, F. ORCID: https://orcid.org/0000-0001-6097-5422, Brylka, L. ORCID: https://orcid.org/0000-0003-4734-9966, Mashreghi, M.F. ORCID: https://orcid.org/0000-0002-8015-6907, Kusumbe, A. ORCID: https://orcid.org/0000-0002-1911-5495, Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Schinke, T. ORCID: https://orcid.org/0000-0002-8576-0177, Vincent, T.L.. and Löhning, M. ORCID: https://orcid.org/0000-0001-6382-7281
Nature Communications 13 (1): 3059. 1 June 2022

Genome engineering in rodents - status quo and perspectives.
Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803
Laboratory Animals 56 (1): 83-87. 1 February 2022

Susceptibility to diet-induced obesity at thermoneutral conditions is independent of UCP1.
Dieckmann, S., Strohmeyer, A., Willershäuser, M., Maurer, S.F., Wurst, W., Marschall, S., Hrabě de Angelis, M., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Worthmann, A., Fuh, M.M., Heeren, J., Köhler, N., Pauling, J.K. and Klingenspor, M.
American Journal of Physiology Endocrinology and Metabolism 322 (2): E85-E100. February 2022

Generation of a NES-mScarlet red fluorescent reporter human iPSC line for live cell imaging and flow cytometric analysis and sorting using CRISPR-Cas9-mediated gene editing.
Nouri, P., Zimmer, A., Brüggemann, S., Friedrich, R., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803 and Prakash, N. ORCID: https://orcid.org/0000-0002-0568-6262
Cells 11 (2): 268. 13 January 2022

Microglia sense neuronal activity via GABA in the early postnatal hippocampus.
Logiacco, F. ORCID: https://orcid.org/0000-0003-4696-2240, Xia, P. ORCID: https://orcid.org/0000-0001-5086-1755, Georgiev, S.V. ORCID: https://orcid.org/0000-0001-7978-8811, Franconi, C., Chang, Y.J., Ugursu, B. ORCID: https://orcid.org/0000-0002-2488-4141, Sporbert, A. ORCID: https://orcid.org/0000-0002-3738-1295, Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Kettenmann, H. ORCID: https://orcid.org/0000-0001-8208-0291 and Semtner, M. ORCID: https://orcid.org/0000-0001-9379-9023
Cell Reports 37 (13): 110128. 28 December 2021

Base editing repairs an SGCA mutation in human primary muscle stem cells.
Escobar, H. ORCID: https://orcid.org/0000-0002-8128-7845, Krause, A. ORCID: https://orcid.org/0000-0001-9515-2477, Keiper, S., Kieshauer, J. ORCID: https://orcid.org/0000-0002-6924-8616, Müthel, S. ORCID: https://orcid.org/0000-0002-3525-8859, García de Paredes, M., Metzler, E. ORCID: https://orcid.org/0000-0003-1735-6364, Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Heyd, F. and Spuler, S. ORCID: https://orcid.org/0000-0002-0155-1117
JCI Insight 6 (10): e145994. 24 May 2021

Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome.
Inak, G., Rybak-Wolf, A. ORCID: https://orcid.org/0000-0002-1192-5290, Lisowski, P. ORCID: https://orcid.org/0000-0002-3634-1072, Pentimalli, T.M. ORCID: https://orcid.org/0000-0002-8461-7918, Jüttner, R. ORCID: https://orcid.org/0000-0003-3565-0698, Glažar, P. ORCID: https://orcid.org/0000-0003-0842-0088, Uppal, K., Bottani, E. ORCID: https://orcid.org/0000-0003-1217-8722, Brunetti, D. ORCID: https://orcid.org/0000-0002-2740-9370, Secker, C. ORCID: https://orcid.org/0000-0002-7222-536X, Zink, A. ORCID: https://orcid.org/0000-0002-8489-6339, Meierhofer, D. ORCID: https://orcid.org/0000-0002-0170-868X, Henke, M.T. ORCID: https://orcid.org/0000-0001-6572-1667, Dey, M. ORCID: https://orcid.org/0000-0002-9987-575X, Ciptasari, U. ORCID: https://orcid.org/0000-0003-4577-3069, Mlody, B. ORCID: https://orcid.org/0000-0001-5184-1772, Hahn, T., Berruezo-Llacuna, M., Karaiskos, N. ORCID: https://orcid.org/0000-0001-7771-3947, Di Virgilio, M. ORCID: https://orcid.org/0000-0001-5189-0793, Mayr, J.A. ORCID: https://orcid.org/0000-0001-6970-336X, Wortmann, S.B., Priller, J. ORCID: https://orcid.org/0000-0001-7596-0979, Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172, Jones, D.P., Mayatepek, E., Stenzel, W., Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Wanker, E.E. ORCID: https://orcid.org/0000-0001-8072-1630, Rajewsky, N. ORCID: https://orcid.org/0000-0002-4785-4332, Schuelke, M. ORCID: https://orcid.org/0000-0003-2824-3891 and Prigione, A. ORCID: https://orcid.org/0000-0001-9457-1952
Nature Communications 12 (1): 1929. 26 March 2021

A homology independent sequence replacement strategy in human cells using a CRISPR nuclease.
Danner, E. ORCID: https://orcid.org/0000-0003-3277-5727, Lebedin, M. ORCID: https://orcid.org/0000-0002-3877-7195, de la Rosa, K. ORCID: https://orcid.org/0000-0003-4809-3157 and Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803
Open Biology 11 (1): 200283. January 2021

Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density.
Swan, A.L. ORCID: https://orcid.org/0000-0003-1810-3756, Schütt, C., Rozman, J. ORCID: https://orcid.org/0000-0002-8035-8904, Del Mar Muñiz Moreno, M. ORCID: https://orcid.org/0000-0002-2662-890X, Brandmaier, S., Simon, M., Leuchtenberger, S. ORCID: https://orcid.org/0000-0003-2475-0810, Griffiths, M., Brommage, R. ORCID: https://orcid.org/0000-0002-9947-3822, Keskivali-Bond, P., Grallert, H. ORCID: https://orcid.org/0000-0002-6876-9655, Werner, T. ORCID: https://orcid.org/0000-0003-0402-4539, Teperino, R. ORCID: https://orcid.org/0000-0001-8815-1409, Becker, L. ORCID: https://orcid.org/0000-0002-6890-4984, Miller, G. ORCID: https://orcid.org/0000-0002-4281-4905, Moshiri, A., Seavitt, J.R. ORCID: https://orcid.org/0000-0003-3209-3187, Cissell, D.D. ORCID: https://orcid.org/0000-0002-6450-422X, Meehan, T.F., Acar, E.F. ORCID: https://orcid.org/0000-0003-2908-7691, Lelliott, C.J. ORCID: https://orcid.org/0000-0001-8087-4530, Flenniken, A.M., Champy, M.F., Sorg, T., Ayadi, A., Braun, R.E. ORCID: https://orcid.org/0000-0003-3856-9465, Cater, H. ORCID: https://orcid.org/0000-0002-8696-6070, Dickinson, M.E., Flicek, P. ORCID: https://orcid.org/0000-0002-3897-7955, Gallegos, J., Ghirardello, E.J. ORCID: https://orcid.org/0000-0002-1100-9217, Heaney, J.D. ORCID: https://orcid.org/0000-0001-8475-8828, Jacquot, S., Lally, C. ORCID: https://orcid.org/0000-0002-3801-1966, Logan, J.G. ORCID: https://orcid.org/0000-0003-2801-700X, Teboul, L., Mason, J. ORCID: https://orcid.org/0000-0002-2796-5123, Spielmann, N., McKerlie, C., Murray, S.A., Nutter, L.M.J. ORCID: https://orcid.org/0000-0001-9619-146X, Odfalk, K.F. ORCID: https://orcid.org/0000-0003-4152-4583, Parkinson, H., Prochazka, J. ORCID: https://orcid.org/0000-0003-4675-8995, Reynolds, C.L., Selloum, M. ORCID: https://orcid.org/0000-0003-4057-3519, Spoutil, F. ORCID: https://orcid.org/0000-0002-7310-3487, Svenson, K.L. ORCID: https://orcid.org/0000-0002-7928-1911, Vales, T.S. ORCID: https://orcid.org/0000-0001-9751-5681, Wells, S.E. ORCID: https://orcid.org/0000-0002-0572-0600, White, J.K. ORCID: https://orcid.org/0000-0001-6268-2826, Sedlacek, R. ORCID: https://orcid.org/0000-0002-3352-392X, Wurst, W. ORCID: https://orcid.org/0000-0003-4422-7410, Lloyd, K.K.C. ORCID: https://orcid.org/0000-0002-5318-4144, Croucher, P.I., Fuchs, H., Williams, G.R. ORCID: https://orcid.org/0000-0002-8555-8219, Bassett, D., Gailus-Durner, V., Herault, Y. ORCID: https://orcid.org/0000-0001-7049-6900, Mallon, A.M., Brown, S.D.M. ORCID: https://orcid.org/0000-0002-0617-4824, Mayer-Kuckuk, P. and Hrabe de Angelis, M. ORCID: https://orcid.org/0000-0002-7898-2353
PLoS Genetics 16 (12): e1009190. 28 December 2020

CRISPR/Cas9-mediated ELANE mutation correction in hematopoietic stem and progenitor cells to treat severe congenital neutropenia.
Tran, N.T. ORCID: https://orcid.org/0000-0003-0896-8641, Graf, R. ORCID: https://orcid.org/0000-0002-5400-9938, Wulf-Goldenberg, A., Stecklum, M., Strauß, G., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Kocks, C. ORCID: https://orcid.org/0000-0003-1749-3334, Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Chu, V.T. ORCID: https://orcid.org/0000-0003-1327-8696
Molecular Therapy 28 (12): 2621-2634. 2 December 2020

B-cell-specific Myd88 L252P expression causes a premalignant gammopathy resembling IgM MGUS.
Schmidt, K., Sack, U., Graf, R. ORCID: https://orcid.org/0000-0002-5400-9938, Winkler, W. ORCID: https://orcid.org/0000-0001-8807-9259, Popp, O. ORCID: https://orcid.org/0000-0001-6240-4666, Mertins, P. ORCID: https://orcid.org/0000-0002-2245-528X, Sommermann, T. ORCID: https://orcid.org/0000-0003-2899-0256, Kocks, C. ORCID: https://orcid.org/0000-0003-1749-3334 and Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
Frontiers in Immunology 11 : 602868. 1 December 2020

Enhancement of CRISPR-Cas9 induced precise gene editing by targeting Histone H2A-K15 ubiquitination.
Bashir, S. ORCID: https://orcid.org/0000-0002-1281-8710, Dang, T. ORCID: https://orcid.org/0009-0001-0138-7599, Rossius, J. ORCID: https://orcid.org/0009-0000-6011-9714, Wolf, J. and Kuehn, R. ORCID: https://orcid.org/0000-0003-1694-9803
BMC Biotechnology 20 (1): 57. 23 October 2020

Human and mouse essentiality screens as a resource for disease gene discovery.
Cacheiro, P. ORCID: https://orcid.org/0000-0002-6335-8208, Muñoz-Fuentes, V. ORCID: https://orcid.org/0000-0003-3574-546X, Murray, S.A., Dickinson, M.E., Bucan, M., Nutter, L.M.J. ORCID: https://orcid.org/0000-0001-9619-146X, Peterson, K.A. ORCID: https://orcid.org/0000-0001-8353-3694, Haselimashhadi, H. ORCID: https://orcid.org/0000-0001-7334-2421, Flenniken, A.M., Morgan, H., Westerberg, H., Konopka, T. ORCID: https://orcid.org/0000-0003-3042-4712, Hsu, C.W. ORCID: https://orcid.org/0000-0002-9591-9567, Christiansen, A., Lanza, D.G. ORCID: https://orcid.org/0000-0001-8750-6933, Beaudet, A.L., Heaney, J.D. ORCID: https://orcid.org/0000-0001-8475-8828, Fuchs, H. ORCID: https://orcid.org/0000-0002-5143-2677, Gailus-Durner, V. ORCID: https://orcid.org/0000-0002-6076-0111, Sorg, T., Prochazka, J., Novosadova, V., Lelliott, C.J. ORCID: https://orcid.org/0000-0001-8087-4530, Wardle-Jones, H., Wells, S., Teboul, L., Cater, H., Stewart, M., Hough, T., Wurst, W., Sedlacek, R., Adams, D.J. ORCID: https://orcid.org/0000-0001-9490-0306, Seavitt, J.R., Tocchini-Valentini, G., Mammano, F. ORCID: https://orcid.org/0000-0003-3751-1691, Braun, R.E., McKerlie, C. ORCID: https://orcid.org/0000-0002-2232-0967, Herault, Y. ORCID: https://orcid.org/0000-0001-7049-6900, de Angelis, M.H. ORCID: https://orcid.org/0000-0002-7898-2353, Mallon, A.M., Lloyd, K.C.K. ORCID: https://orcid.org/0000-0002-5318-4144, Brown, S.D.M., Parkinson, H., Meehan, T.F. and Smedley, D. ORCID: https://orcid.org/0000-0002-5836-9850
Nature Communications 11 (1): 655. 31 January 2020

Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity.
Fecher, C. ORCID: https://orcid.org/0000-0002-7179-7323, Trovò, L., Müller, S.A. ORCID: https://orcid.org/0000-0003-3414-307X, Snaidero, N., Wettmarshausen, J., Heink, S. ORCID: https://orcid.org/0000-0002-3276-6313, Ortiz, O., Wagner, I., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Hartmann, J., Karl, R.M., Konnerth, A., Korn, T. ORCID: https://orcid.org/0000-0002-3633-0955, Wurst, W., Merkler, D. ORCID: https://orcid.org/0000-0002-0247-2007, Lichtenthaler, S.F., Perocchi, F. and Misgeld, T. ORCID: https://orcid.org/0000-0001-9875-6794
Nature Neuroscience 22 (10): 1731-1742. October 2019

Efficient CRISPR/Cas9-mediated gene knockin in mouse hematopoietic stem and progenitor cells.
Tran, N.T. ORCID: https://orcid.org/0000-0003-0896-8641, Sommermann, T. ORCID: https://orcid.org/0000-0003-2899-0256, Graf, R. ORCID: https://orcid.org/0000-0002-5400-9938, Trombke, J. ORCID: https://orcid.org/0000-0002-8746-1795, Pempe, J., Petsch, K., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Chu, V.T. ORCID: https://orcid.org/0000-0003-1327-8696
Cell Reports 28 (13): 3510-3522. 24 September 2019

Efficient and precise CRISPR/Cas9-mediated MECP2 modifications in human-induced pluripotent stem cells.
Le, T.T.H., Tran, N.T. ORCID: https://orcid.org/0000-0003-0896-8641, Dao, T.M.L., Nguyen, D.D., Do, H.D., Ha, T.L., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Nguyen, T.L., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Chu, V.T. ORCID: https://orcid.org/0000-0003-1327-8696
Frontiers in Genetics 10 : 625. July 2019

Chronic CD30-signaling in B cells results in lymphomagenesis by driving the expansion of plasmablasts and B1 cells.
Sperling, S.A., Fiedler, P., Lechner, M., Pollithy, A., Ehrenberg, S., Schiefer, A.I., Kenner, L., Feuchtinger, A., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Swinerd, G., Schmidt-Supprian, M., Strobl, L.J. and Zimber-Strobl, U.
Blood 133 (24): 2597-2609. 13 June 2019

Oscillations of MyoD and Hes1 proteins regulate the maintenance of activated muscle stem cells.
Lahmann, I. ORCID: https://orcid.org/0000-0003-0640-4519, Bröhl, D., Zyrianova, T. ORCID: https://orcid.org/0000-0003-4295-6708, Isomura, A., Czajkowski, M.T. ORCID: https://orcid.org/0000-0002-0122-1943, Kapoor, V. ORCID: https://orcid.org/0000-0001-5331-7966, Griger, J. ORCID: https://orcid.org/0000-0001-8666-3371, Ruffault, P.L. ORCID: https://orcid.org/0000-0002-3378-3828, Mademtzoglou, D. ORCID: https://orcid.org/0000-0002-4494-7234, Zammit, P.S., Wunderlich, T., Spuler, S. ORCID: https://orcid.org/0000-0002-0155-1117, Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Preibisch, S. ORCID: https://orcid.org/0000-0002-0276-494X, Wolf, J. ORCID: https://orcid.org/0000-0003-3254-5868, Kageyama, R. and Birchmeier, C. ORCID: https://orcid.org/0000-0002-2041-8872
Genes & Development 33 (9-10): 524-535. 1 May 2019

Enhancement of precise gene editing by the association of Cas9 with homologous recombination factors.
Tran, N.T. ORCID: https://orcid.org/0000-0003-0896-8641, Bashir, S. ORCID: https://orcid.org/0000-0002-1281-8710, Li, X. ORCID: https://orcid.org/0000-0002-1173-1066, Rossius, J. ORCID: https://orcid.org/0009-0000-6011-9714, Chu, V.T. ORCID: https://orcid.org/0000-0003-1327-8696, Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803
Frontiers in Genetics 10 : 365. 30 April 2019

The Parkinson's disease-linked Leucine-rich repeat kinase 2 (LRRK2) is required for insulin-stimulated translocation of GLUT4.
Funk, N., Munz, M., Ott, T., Brockmann, K., Wenninger-Weinzierl, A., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Vogt-Weisenhorn, D., Giesert, F., Wurst, W., Gasser, T. and Biskup, S.
Scientific Reports 9 (1): 4515. 14 March 2019

Efficient gene editing of human induced pluripotent stem cells using CRISPR/Cas9.
Yumlu, S., Bashir, S. ORCID: https://orcid.org/0000-0002-1281-8710, Stumm, J. and Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803
Methods in Molecular Biology 1961 : 137-151. 2019

Regulation of the natriuretic peptide receptor 2 (Npr2) by phosphorylation of juxtamembrane serine and threonine residues is essential for bifurcation of sensory axons.
Schmidt, H., Dickey, D.M., Dumoulin, A. ORCID: https://orcid.org/0000-0002-2420-6877, Octave, M., Robinson, J.W., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Feil, R., Potter, L.R. and Rathjen, F.G. ORCID: https://orcid.org/0000-0001-5351-613X
Journal of Neuroscience 38 (45): 9768-9780. 7 November 2018

Mutations in disordered regions can cause disease by creating dileucine motifs.
Meyer, K. ORCID: https://orcid.org/0000-0002-8244-6887, Kirchner, M. ORCID: https://orcid.org/0000-0002-7049-534X, Uyar, B. ORCID: https://orcid.org/0000-0002-3170-4890, Cheng, J.Y. ORCID: https://orcid.org/0000-0001-8942-0607, Russo, G., Hernandez-Miranda, L.R. ORCID: https://orcid.org/0000-0002-0498-708X, Szymborska, A. ORCID: https://orcid.org/0000-0003-1741-4106, Zauber, H. ORCID: https://orcid.org/0000-0003-2595-1147, Rudolph, I.M. ORCID: https://orcid.org/0000-0002-3903-0755, Willnow, T.E. ORCID: https://orcid.org/0000-0001-9515-7921, Akalin, A. ORCID: https://orcid.org/0000-0002-0468-0117, Haucke, V. ORCID: https://orcid.org/0000-0003-3119-6993, Gerhardt, H. ORCID: https://orcid.org/0000-0002-3030-0384, Birchmeier, C. ORCID: https://orcid.org/0000-0002-2041-8872, Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Krauss, M., Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Pascual, J.M. and Selbach, M. ORCID: https://orcid.org/0000-0003-2454-8751
Cell 175 (1): 239-253. 20 September 2018

Identification of genetic elements in metabolism by high-throughput mouse phenotyping.
Rozman, J. ORCID: https://orcid.org/0000-0002-8035-8904, Rathkolb, B., Oestereicher, M.A., Schütt, C., Ravindranath, A.C., Leuchtenberger, S., Sharma, S., Kistler, M., Willershäuser, M., Brommage, R., Meehan, T.F., Mason, J., Haselimashhadi, H., Hough, T., Mallon, A.M., Wells, S., Santos, L., Lelliott, C.J., White, J.K., Sorg, T., Champy, M.F., Bower, L.R., Reynolds, C. L., Flenniken, A.M., Murray, St.A., Nutter, L.M.J., Svenson, K.L., West, D., Tocchini-Valentini, G.P., Beaudet, A.L., Bosch, F., Braun, R.B., Dobbie, M.S., Gao, X., Herault, Y., Moshiri, A., Moore, B.A., Kent Lloyd, K.C., McKerlie, C., Masuya, H., Tanaka, N., Flicek, P., Parkinson, H.E., Sedlacek, R., Seong, J.K., Wang, C.K.L., Moore, M., Brown, S.D., Tschöp, M.H., Wurst, W., Klingenspor, M., Wolf, E., Beckers, J., Machicao, F., Peter, A., Staiger, H., Häring, H.U., Grallert, H., Campillos, M., Maier, H., Fuchs, H., Gailus-Durner, V., Werner, T. and Hrabe de Angelis, M.
Nature Communications 9 (1): 288. 18 January 2018

A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction.
Bowl, M.R., Simon, M.M., Ingham, N.J., Greenaway, S., Santos, L., Cater, H., Taylor, S., Mason, J., Kurbatova, N., Pearson, S., Bower, L.R., Clary, D.A., Meziane, H., Reilly, P., Minowa, O., Kelsey, L., Tocchini-Valentini, G.P., Gao, X., Bradley, A., Skarnes, W.C., Moore, M., Beaudet, A.L., Justice, M.J., Seavitt, J., Dickinson, M.E., Wurst, W., Hrabe de Angelis, M., Herault, Y., Wakana, S., Nutter, L.M.J., Flenniken, A.M., McKerlie, C., Murray, S.A., Svenson, K.L., Braun, R.E., West, D.B., Lloyd, K.C.K., Adams, D.J., White, J., Karp, N., Flicek, P., Smedley, D., Meehan, T.F., Parkinson, H.E., Teboul, L.M., Wells, S., Steel, K.P., Mallon, A.M. and Brown, S.D.M.
Nature Communications 8 (1): 886. 12 October 2017

Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function.
Piwecka, M. ORCID: https://orcid.org/0000-0003-4104-6577, Glažar, P. ORCID: https://orcid.org/0000-0003-0842-0088, Hernandez-Miranda, L.R. ORCID: https://orcid.org/0000-0002-0498-708X, Memczak, S. ORCID: https://orcid.org/0000-0001-9518-7135, Wolf, S.A. ORCID: https://orcid.org/0000-0003-0922-8418, Rybak-Wolf, A. ORCID: https://orcid.org/0000-0002-1192-5290, Filipchyk, A. ORCID: https://orcid.org/0000-0002-2029-8460, Klironomos, F., Cerda Jara, C.A. ORCID: https://orcid.org/0000-0003-1783-5533, Fenske, P., Trimbuch, T. ORCID: https://orcid.org/0000-0001-7512-8955, Zywitza, V. ORCID: https://orcid.org/0000-0003-3055-8569, Plass, M. ORCID: https://orcid.org/0000-0002-9891-2723, Schreyer, L., Ayoub, S. ORCID: https://orcid.org/0000-0001-5043-8922, Kocks, C. ORCID: https://orcid.org/0000-0003-1749-3334, Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Rosenmund, C. ORCID: https://orcid.org/0000-0002-3905-2444, Birchmeier, C. ORCID: https://orcid.org/0000-0002-2041-8872 and Rajewsky, N. ORCID: https://orcid.org/0000-0002-4785-4332
Science 357 (6357): eaam8526. 22 September 2017

Elevated glutaric acid levels in Dhtkd1-/Gcdh- double knockout mice challenge our current understanding of lysine metabolism.
Biagosch, C., Ediga, R.D., Hensler, S.V., Faerberboeck, M., Kuehn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Wurst, W., Meitinger, T., Kölker, S., Sauer, S. and Prokisch, H.
Biochimica et Biophysica Acta - Molecular Basis of Disease 1863 (9): 2220-2228. September 2017

Control of gene editing by manipulation of DNA repair mechanisms.
Danner, E. ORCID: https://orcid.org/0000-0003-3277-5727, Bashir, S. ORCID: https://orcid.org/0000-0002-1281-8710, Yumlu, S., Wurst, W., Wefers, B. and Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803
Mammalian Genome 28 (7-8): 262-274. August 2017

Gene editing and clonal isolation of human induced pluripotent stem cells using CRISPR/Cas9.
Yumlu, S., Stumm, J., Bashir, S. ORCID: https://orcid.org/0000-0002-1281-8710, Dreyer, A.K. ORCID: https://orcid.org/0000-0001-6586-9282, Lisowski, P. ORCID: https://orcid.org/0000-0002-3634-1072, Danner, E. ORCID: https://orcid.org/0000-0003-3277-5727 and Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803
Methods 121-122 : 29-44. 15 May 2017

Gene editing in mouse zygotes using the CRISPR/Cas9 system.
Wefers, B., Bashir, S. ORCID: https://orcid.org/0000-0002-1281-8710, Rossius, J. ORCID: https://orcid.org/0009-0000-6011-9714 and Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803
Methods 121-122 : 55-67. 15 May 2017

Fusion of SpCas9 to E.coli Rec A protein enhances CRISPR-Cas9 mediated gene knockout in mammalian cells.
Lin, L., Petersen, T.S., Jensen, K.T., Bolund, L., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803 and Luo, Y.
Journal of Biotechnology 247 : 42-49. 10 April 2017

Caspase-mediated apoptosis induction in zebrafish cerebellar Purkinje neurons.
Weber, T., Namikawa, K., Winter, B., Müller-Brown, K., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Wurst, W. and Köster, R.W.
Development 143 (22): 4279-4287. 15 November 2016

Efficient CRISPR-mediated mutagenesis in primary immune cells using CrispRGold and a C57BL/6 Cas9 transgenic mouse line.
Chu, V.T. ORCID: https://orcid.org/0000-0003-1327-8696, Graf, R. ORCID: https://orcid.org/0000-0002-5400-9938, Wirtz, T. ORCID: https://orcid.org/0009-0005-5677-9804, Weber, T. ORCID: https://orcid.org/0000-0003-2079-842X, Favret, J., Li, X. ORCID: https://orcid.org/0000-0002-1173-1066, Petsch, K., Tran, N.T. ORCID: https://orcid.org/0000-0003-0896-8641, Sieweke, M.H. ORCID: https://orcid.org/0000-0002-3228-9537, Berek, C., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803 and Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
Proceedings of the National Academy of Sciences of the United States of America 113 (44): 12514-12519. 1 November 2016

Efficient generation of Rosa26 knock-in mice using CRISPR/Cas9 in C57BL/6 zygotes.
Chu, V.T. ORCID: https://orcid.org/0000-0003-1327-8696, Weber, T. ORCID: https://orcid.org/0000-0003-2079-842X, Graf, R. ORCID: https://orcid.org/0000-0002-5400-9938, Sommermann, T. ORCID: https://orcid.org/0000-0003-2899-0256, Petsch, K., Sack, U., Volchkov, P., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803
BMC Biotechnology 16 (1): 4. 16 January 2016

Genome editing in mice using TALE nucleases.
Wefers, B., Brandl, C., Ortiz, O., Wurst, W. and Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803
Methods in Molecular Biology 1338 : 229-243. 2016

Conditional reduction of adult born doublecortin-positive neurons reversibly impairs selective behaviors.
Garrett, L., Zhang, J., Zimprich, A., Niedermeier, K.M., Fuchs, H., Gailus-Durner, V., Hrabe de Angelis, M., Vogt Weisenhorn, D., Wurst, W. and Hoelter, S.M.
Frontiers in Behavioral Neuroscience 9 : 302. 12 November 2015

Development of an intein-mediated split-Cas9 system for gene therapy.
Truong, D.J.J., Kühner, K., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Werfel, S., Engelhardt, S., Wurst, W. and Ortiz, O.
Nucleic Acids Research 43 (13): 6450-6458. 27 July 2015

Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells.
Chu, V.T. ORCID: https://orcid.org/0000-0003-1327-8696, Weber, T. ORCID: https://orcid.org/0000-0003-2079-842X, Wefers, B., Wurst, W., Sander, S. ORCID: https://orcid.org/0000-0003-4645-3366, Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803
Nature Biotechnology 33 (5): 543-548. May 2015

Creation of targeted genomic deletions using TALEN or CRISPR/Cas nuclease pairs in one-cell mouse embryos.
Brandl, C., Ortiz, O., Röttig, B., Wefers, B., Wurst, W. and Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803
FEBS Open Bio 5 : 26-35. 2015

Generation of targeted mouse mutants by embryo microinjection of TALENs.
Wefers, B., Ortiz, O., Wurst, W. and Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803
Methods 69 (1): 94-101. 15 August 2014

Simple derivation of transgene-free iPS cells by a dual recombinase approach.
Pertek, A., Meier, F., Irmler, M., Beckers, J., Skylaki, S., Endele, M., Wurst, W., Prakash, N. and Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803
Molecular Biotechnology 56 (8): 697-713. August 2014

FGF/FGFR2 signaling regulates the generation and correct positioning of Bergmann glia cells in the developing mouse cerebellum.
Meier, F., Giesert, F., Delic, S., Faus-Kessler, T., Matheus, F., Simeone, A., Hoelter, S.M., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Vogt-Weisenhorn, D.M., Wurst, W. and Prakash, N.
PLoS ONE 9 (7): e101124. 1 July 2014

Generation of targeted mouse mutants by embryo microinjection of TALEN mRNA.
Wefers, B., Panda, S.K., Ortiz, O., Brandl, C., Hensler, S., Hansen, J., Wurst, W. and Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803
Nature Protocols 8 (12): 2355-2379. December 2013

An RNAi-based approach to down-regulate a gene family in vivo.
Kim, J., Badaloni, A., Willert, T., Zimber-Strobl, U., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Wurst, W. and Kieslinger, M.
PLoS ONE 8 (11): e80312. 12 November 2013

Highly efficient targeted mutagenesis in mice using TALENs.
Panda, S.K., Wefers, B., Ortiz, O., Floss, T., Schmid, B., Haass, C., Wurst, W. and Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803
Genetics 195 (3): 703-713. November 2013

Reversible and tissue-specific activation of MAP kinase signaling by tamoxifen in Braf(V637)ER(T2) mice.
Ortiz, O., Wurst, W. and Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803
Genesis 51 (6): 448-455. June 2013

Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides.
Wefers, B., Meyer, M., Ortiz, O., Hrabé de Angelis, M., Hansen, J., Wurst, W. and Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803
Proceedings of the National Academy of Sciences of the United States of America 110 (10): 3782-3787. 5 March 2013

Characterization of the melanocortin-4-receptor nonsense mutation W16X in vitro and in vivo.
Bolze, F., Rink, N., Brumm, H., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Mocek, S., Schwarz, A.E., Kless, C., Biebermann, H., Wurst, W., Rozman, J. and Klingenspor, M.
Pharmacogenomics Journal 13 (1): 80-93. February 2013

Efficient generation of rat induced pluripotent stem cells using a non-viral inducible vector.
Merkl, C., Saalfrank, A., Riesen, N., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Pertek, A., Eser, S., Hardt, M.S., Kind, A., Saur, D., Wurst, W., Iglesias, A. and Schnieke, A.
PLoS ONE 8 (1): e55170. 31 January 2013

Target validation in mice by constitutive and conditional RNAi.
Kleinhammer, A., Wurst, W. and Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803
Methods in Molecular Biology 986 : 307-323. 23 January 2013

Gene editing in one-cell embryos by zinc-finger and TAL nucleases.
Wefers, B., Meyer, M., Hensler, S., Panda, S., Ortiz, O., Wurst, W. and Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803
Current Protocols in Mouse Biology 2 : 347-364. December 2012

In vivo functional requirement of the mouse Ifitm1 gene for germ cell development, interferon mediated immune response and somitogenesis.
Klymiuk, I., Kenner, L., Adler, T., Busch, D.H., Boersma, A., Irmler, M., Fridrich, B., Gailus-Durner, V., Fuchs, H., Leitner, N., Mueller, M., Kuehn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Schlederer, M., Treise, I., de Angelis, M.H. and Beckers, J.
PLoS ONE 7 (10): e44609. 24 October 2012

Humanized c-Myc mouse.
Lehmann, F.M., Feicht, S., Helm, F., Maurberger, A., Ladinig, C., Zimber-Strobl, U., Kuehn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Mautner, J., Gerbitz, A. and Bornkamm, G.W.
PLoS ONE 7 (7): e42021. 31 July 2012

Modeling disease mutations by gene targeting in one-cell mouse embryos.
Meyer, M., Ortiz, O., Hrabe de Angelis, M., Wurst, W. and Kuehn, R. ORCID: https://orcid.org/0000-0003-1694-9803
Proceedings of the National Academy of Sciences of the United States of America 109 (24): 9354-9359. 12 June 2012

Pink1-deficiency in mice impairs gait, olfaction and serotonergic innervation of the olfactory bulb.
Glasl, L., Kloos, K., Giesert, F., Roethig, A., Di Benedetto, B., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Zhang, J., Hafen, U., Zerle, J., Hofmann, A., de Angelis, M.H., Winklhofer, K.F., Hölter, S.M., Vogt Weisenhorn, D.M. and Wurst, W.
Experimental Neurology 235 (1): 214-227. May 2012

MAPK signaling determines anxiety in the juvenile mouse brain but depression-like behavior in adults.
Wefers, B., Hitz, C., Hoelter, S.M., Truembach, D., Hansen, J., Weber, P., Puetz, B., Deussing, J.M., de Angelis, M.H., Roenneberg, T., Zheng, F., Alzheimer, C., Silva, A., Wurst, W. and Kuehn, R. ORCID: https://orcid.org/0000-0003-1694-9803
PLoS ONE 7 (4): e35035. 18 April 2012

N-desalkylquetiapine activates ERK1/2 to induce GDNF release in C6 glioma cells: a putative cellular mechanism for quetiapine as antidepressant.
Di Benedetto, B., Kuehn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Nothdurfter, C., Rein, T., Wurst, W. and Rupprecht, R.
Neuropharmacology 62 (1): 209-216. January 2012

Genetic models of Parkinson's disease.
Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Vogt-Weisenhorn, D. and Wurst, W.
NeuroMethods 61 : 243-265. 2012

CD19-independent instruction of murine marginal zone B-cell development by constitutive Notch2 signaling.
Hampel, F., Ehrenberg, S., Hojer, C., Draeseke, A., Marschall-Schröter, G., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Mack, B., Gires, O., Vahl, C.J., Schmidt-Supprian, M., Strobl, L.J. and Zimber-Strobl, U.
Blood 118 (24): 6321-631. 8 December 2011

Constitutive and conditional RNAi transgenesis in mice.
Kleinhammer, A., Wurst, W. and Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803
Methods 53 (4): 430-436. April 2011

Design and generation of gene-targeting vectors.
Wefers, B., Wurst, W. and Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803
Current Protocols in Mouse Biology 1 : 199-211. March 2011

Generating conditional knockout mice.
Friedel, R.H., Wurst, W., Wefers, B. and Kuehn, R. ORCID: https://orcid.org/0000-0003-1694-9803
Methods in Molecular Biology 693 : 205-231. 2011

Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases.
Meyer, M., de Angelis, M.H., Wurst, W. and Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803
Proceedings of the National Academy of Sciences of the United States of America 107 (34): 15022-15026. 24 August 2010

Phenotypic annotation of the mouse X chromosome.
Cox, B.J., Vollmer, M., Tamplin, O., Lu, M., Biechele, S., Gertsenstein, M., van Campenhout, C., Floss, T., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Wurst, W., Lickert, H. and Rossant, J.
Genome Research 20 (8): 1154-1164. August 2010

Local knockdown of ERK2 in the adult mouse brain via adeno-associated virus-mediated RNA interference.
Di Benedetto, B., Wefers, B., Wurst, W. and Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803
Molecular Biotechnology 41 (3): 263-269. March 2009

Generation of shRNA transgenic mice.
Hitz, C., Steuber-Buchberger, P., Delic, S., Wurst, W. and Kuehn, R. ORCID: https://orcid.org/0000-0003-1694-9803
Methods in Molecular Biology 530 : 101-129. 2009

Overview on mouse mutagenesis.
Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803 and Wurst, W.
Methods in Molecular Biology 530 : 1-12. 2009

Genetic mouse models for behavioral analysis through transgenic RNAi technology.
Delic, S., Streif, S., Deussing, J.M., Weber, P., Ueffing, M., Hoelter, S.M., Wurst, W. and Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803
Genes Brain and Behavior 7 (7): 821-830. October 2008

Novel caspase-suicide proteins for tamoxifen-inducible apoptosis.
Chu, Y., Senghaas, N., Koester, R.W., Wurst, W. and Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803
Genesis 46 (10): 530-536. October 2008

Sall4 isoforms act during proximal-distal and anterior-posterior axis formation in the mouse embryo.
Uez, N., Lickert, H., Kohlhase, J., de Angelis, M.H., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Wurst, W. and Floss, T.
Genesis 46 (9): 463-477. September 2008

Simultaneous Cre-mediated conditional knockdown of two genes in mice.
Steuber-Buchberger, P., Wurst, W. and Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803
Genesis 46 (3): 144-151. March 2008

Conditional brain-specific knockdown of MAPK using Cre/loxP regulated RNA interference.
Hitz, C., Wurst, W. and Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803
Nucleic Acids Research 35 (12): e90. June 2007

Differential mRNA distribution of components of the ERK/MAPK signalling cascade in the adult mouse brain.
Di Benedetto, B., Hitz, C., Hoelter, S.M., Kuehn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Vogt Weisenhorn, D.M. and Wurst, W.
Journal of Comparative Neurology 500 (3): 542-556. 20 January 2007

Development of a species-specific RNA polymerase I-based shRNA expression vector.
Brenz Verca, M.S., Weber, P., Mayer, C., Graf, C., Refojo, D., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Grummt, I. and Lutz, B.
Nucleic Acids Research 35 (2): e10. January 2007

Inducible gene deletion in astroglia and radial glia--a valuable tool for functional and lineage analysis.
Mori, T., Tanaka, K., Buffo, A., Wurst, W., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803 and Goetz, M.
Glia 54 (1): 21-34. July 2006

Forebrain-specific knockout of B-raf kinase leads to deficits in hippocampal long-term potentiation, learning, and memory.
Chen, A.P., Ohno, M., Giese, K.P., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Chen, R.L. and Silva, A.J.
Journal of Neuroscience Research 83 (1): 28-38. January 2006

Single copy shRNA configuration for ubiquitous gene knockdown in mice.
Seibler, J., Küter-Luks, B., Kern, H., Streu, S., Plum, L., Mauer, J., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Bruening, J.C. and Schwenk, F.
Nucleic Acids Research 33 (7): e67. 14 April 2005

Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress.
Mueller, M.B., Zimmermann, S., Sillaber, I., Hagemeyer, T.P., Deussing, J.M., Timpl, P., Kormann, M.S.D., Droste, S.K., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Reul, J.M.H.M., Holsboer, F. and Wurst, W.
Nature Neuroscience 6 (10): 1100-1107. October 2003

Connexin43 is not expressed in principal cells of mouse cortex and hippocampus.
Theis, M., Soehl, G., Speidel, D., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803 and Willecke, K.
European Journal of Neuroscience 18 (2): 267-274. July 2003

Hybrid embryonic stem cell-derived tetraploid mice show apparently normal morphological, physiological, and neurological characteristics.
Schwenk, F., Zevnik, B., Bruening, J., Roehl, M., Willuweit, A., Rode, A., Hennek, T., Kauselmann, G., Jaenisch, R. and Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803
Molecular and Cellular Biology 23 (11): 3982-3989. June 2003

Rapid generation of inducible mouse mutants.
Seibler, J., Zevnik, B., Küter-Luks, B., Andreas, S., Kern, H., Hennek, T., Rode, A., Heimann, C., Faust, N., Kauselmann, G., Schoor, M., Jaenisch, R., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370, Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803 and Schwenk, F.
Nucleic Acids Research 31 (4): e12. 15 February 2003

Neuron-specific ablation of PDGF-B is compatible with normal central nervous system development and astroglial response to injury.
Enge, M., Wilhelmsson, U., Abramsson, A., Stakeberg, J., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Betsholtz, C. and Pekny, M.
Neurochemical Research 28 (2): 271-279. February 2003

Enhanced efficiency through nuclear localization signal fusion on phage PhiC31-integrase: activity comparison with Cre and FLPe recombinase in mammalian cells.
Andreas, S., Schwenk, F., Kueter-Luks, B., Faust, N. and Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803
Nucleic Acids Research 30 (11): 2299-2306. 1 June 2002

Male and female mice derived from the same embryonic stem cell clone by tetraploid embryo complementation.
Eggan, K., Rode, A., Jentsch, I., Samuel, C., Hennek, T., Tintrup, H., Zevnik, B., Erwin, J., Loring, J., Jackson-Grusby, L., Speicher, M.R., Kuehn, R. ORCID: https://orcid.org/0000-0003-1694-9803 and Jaenisch, R.
Nature Biotechnology 20 (5): 455-459. May 2002

Conditional knockout mice.
Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803 and Schwenk, F.
Methods in Molecular Biology 209 : 159-185. 2002

Cre/loxP recombination system and gene targeting.
Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803 and Torres, R.M.
Methods in Molecular Biology 180 (5): 175-204. 2002

Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity.
Rios, M., Fan, G., Fekete, C., Kelly, J., Bates, B., Kuehn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Lechan, R.M. and Jaenisch, R.
Molecular Endocrinology 15 (10): 1748-1757. October 2001

Actin pedestal formation by enteropathogenic Escherichia coli and intracellular motility of Shigella flexneri are abolished in N-WASP-defective cells.
Lommel, S., Benesch, S., Rottner, K., Franz, T., Wehland, J. and Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803
EMBO Reports 2 (9): 850-857. September 2001

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics.
Roberds, S.L., Anderson, J., Basi, G., Bienkowski, M.J., Branstetter, D.G., Chen, K.S., Freedman, S.B., Frigon, N.L., Games, D., Hu, K., Johnson-Wood, K., Kappenman, K.E., Kawabe, T.T., Kola, I., Kuehn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Lee, M., Liu, W., Motter, R., Nichols, N.F., Power, M., Robertson, D.W., Schenk, D., Schoor, M., Shopp, GM., Shuck, M.E., Sinha, S., Svensson, K.A., Tatsuno, G., Tintrup, H., Wijsman, J., Wright, S. and McConlogue, L.
Human Molecular Genetics 10 (12): 1317-1324. 1 June 2001

DNA hypomethylation perturbs the function and survival of CNS neurons in postnatal animals.
Fan, G., Beard, C., Chen, R.Z., Csankovszki, G., Sun, Y., Siniaia, M., Biniszkiewicz, D., Bates, B., Lee, P.P., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Trumpp, A., Poon, C., Wilson, C.B. and Jaenisch, R.
Journal of Neuroscience 21 (3): 788-797. 1 February 2001

Essential role for TrkB receptors in hippocampus-mediated learning.
Minichiello, L., Korte, M., Wolfer, D., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Unsicker, K., Cestari, V., Rossi-Arnaud, C., Lipp, H.P., Bonhoeffer, T. and Klein, R.
Neuron 24 (2): 401-414. October 1999

Csk controls antigen receptor-mediated development and selection of T-lineage cells.
Schmedt, C., Saijo, K., Niidome, T., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Aizawa, S. and Tarakhovsky, A.
Nature 394 (6696): 901-904. 27 August 1998

IL-10 regulates liver pathology in acute murine Schistosomiasis mansoni but is not required for immune down-modulation of chronic disease.
Wynn, T.A., Cheever, A.W., Williams, M.E., Hieny, S., Caspar, P., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Müller, W. and Sher, A.
Journal of Immunology 160 (9): 4473-4480. 1 May 1998

Temporally and spatially regulated somatic mutagenesis in mice.
Schwenk, F., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Angrand, P.O., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Stewart, A.F.
Nucleic Acids Research 26 (6): 1427-1432. 15 March 1998

Analysis of granuloma formation in double cytokine-deficient mice reveals a central role for IL-10 in polarizing both T helper cell 1- and T helper cell 2-type cytokine responses in vivo.
Wynn, T.A., Morawetz, R., Scharton-Kersten, T., Hieny, S., Morse III, H.C., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Müller, W., Cheever, A.W. and Sher, A.
Journal of Immunology 159 (10): 5014-5023. November 1997

Generation of Cre recombinase-specific monoclonal antibodies, able to characterize the pattern of Cre expression in cre-transgenic mouse strains.
Schwenk, F., Sauer, B., Kukoč, N., Hoess, R., Müller, W., Kocks, C. ORCID: https://orcid.org/0000-0003-1749-3334, Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803 and Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
Journal of Immunological Methods 207 (2): 203-212. 24 September 1997

In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death.
Lam, K.P., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803 and Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
Cell 90 (6): 1073-1083. 19 September 1997

Interleukin (IL)-4-independent immunoglobulin class switch to immunoglobulin (Ig)E in the mouse.
Morawetz, R.A., Gabriele, L., Rizzo, L.V., Noben-Trauth, N., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370, Müller, W., Doherty, T.M., Finkelman, F., Coffman, R.L. and Morse, H.C.
Journal of Experimental Medicine 184 (5): 1651-1661. 1 November 1996

Plasmodium chabaudi chabaudi: differential susceptibility of gene-targeted mice deficient in IL-10 to an erythrocytic-stage infection.
Linke, A, Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Müller, W, Honarvar, N, Li, C and Langhorne, J
Experimental Parasitology 84 (2): 253-263. November 1996

Impaired immunosuppressive response to ultraviolet radiation in interleukin-10-deficient mice.
Beissert, S., Hosoi, J., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370, Müller, W. and Granstein, R.D.
Journal of Investigative Dermatology 107 (4): 553-557. October 1996

Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses.
Berg, D.J., Davidson, N., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Müller, W., Menon, S., Holland, G., Thompson-Snipes, L., Leach, M.W. and Rennick, D.
Journal of Clinical Investigation 98 (4): 1010-1020. 15 August 1996

Somatic hypermutation occurs in B cells of terminal deoxynucleotidyl transferase-, CD23-, interleukin-4-, IgD- and CD30-deficient mouse mutants.
Texidó, G., Jacobs, H., Meiering, M., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Roes, J., Müller, W., Gilfillan, S., Fujiwara, H., Kikutani, H., Yoshida, N., Amakawa, R., Benoist, C., Mathis, D., Kishimoto, T., Mak, T.W. and Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
European Journal of Immunology 26 (8): 1966-1969. August 1996

In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha.
Gazzinelli, R.T., Wysocka, M., Hieny, S., Scharton-Kersten, T., Cheever, A., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Mueller, W., Trinchieri, G. and Sher, A.
Journal of Immunology 157 (2): 798-805. 15 July 1996

T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice.
Davidson, N.J., Leach, M.W., Fort, M.M., Thompson-Snipes, L., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Müller, W., Berg, D.J. and Rennick, D.M.
Journal of Experimental Medicine 184 (1): 241-251. 1 July 1996

Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant mice.
Carrera, L., Gazzinelli, R.T., Badolato, R., Hieny, S., Mueller, W., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803 and Sacks, D.L.
Journal of Experimental Medicine 183 (2): 515-526. 1 February 1996

Requirement of mammalian DNA polymerase-beta in base-excision repair.
Sobol, R.W., Horton, J.K., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Gu, H., Singhal, R.K., Prasad, R., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Wilson, S.H.
Nature 379 (6561): 183-186. 11 January 1996

Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance.
Berg, D.J., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370, Müller, W., Menon, S., Davidson, N., Grünig, G. and Rennick, D.
Journal of Clinical Investigation 96 (5): 2339-2347. November 1995

Inducible gene targeting in mice.
Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Schwenk, F., Aguet, M. and Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
Science 269 (5229): 1427-1429. 8 September 1995

Antiviral immune responses in mice deficient for both interleukin-2 and interleukin-4.
Bachmann, M.F., Schorle, H., Kuehn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Mueller, W., Hengartner, H., Zinkernagel, R.M. and Horak, I.
Journal of Virology 69 (8): 4842-4846. August 1995

Interleukin 10 but not interleukin 4 is a natural suppressant of cutaneous inflammatory responses.
Berg, D.J., Leach, M.W., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370, Müller, W., Davidson, N.J. and Rennick, D.
Journal of Experimental Medicine 182 (1): 99-108. 1 July 1995

IL-9 production of naive CD4+ T cells depends on IL-2, is synergistically enhanced by a combination of TGF-beta and IL-4, and is inhibited by IFN-gamma.
Schmitt, E., Germann, T., Goedert, S., Hoehn, P., Huels, C., Koelsch, S., Kuehn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Mueller, W., Palm, N. and Ruede, E.
Journal of Immunology 153 (9): 3989-3996. 1 November 1994

Role of IL-12 in the initiation of cell mediated immunity by Toxoplasma gondii and its regulation by IL-10 and nitric oxide.
Gazzinelli, R.T., Hayashi, S., Wysocka, M., Carrera, L., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Müller, W., Roberge, F., Trinchieri, G. and Sher, A.
Journal of Eukaryotic Microbiology 41 (5): 9S. September 1994

MHC class I expression in mice lacking the proteasome subunit LMP-7.
Fehling, H.J., Swat, W., Laplace, C., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370, Müller, U. and von Boehmer, H.
Science 265 (5176): 1234-1237. 26 August 1994

Interleukin-10-deficient mice develop chronic enterocolitis.
Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Löhler, J., Rennick, D., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Müller, W.
Cell 75 (2): 263-274. 22 October 1993

Interleukin-4-deficient mice.
Müller, W, Rajewsky, K and Kuehn, R. ORCID: https://orcid.org/0000-0003-1694-9803
Research in Immunology 144 (8): 637-638. October 1993

T helper cell membranes promote IL-4-independent expression of germ-line Cγ1 transcripts in B cells.
Schultz, C.L., Rothman, P., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Kehry, M., Müller, W., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370, Alt, F. and Coffman, R.L.
Journal of Immunology 149 (1): 60-64. 1 July 1992

Generation and analysis of interleukin-4 deficient mice.
Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Müller, W.
Science 254 (5032): 707-710. 1 November 1991

A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene.
Kitamura, D., Roes, J., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803 and Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
Nature 350 (6317): 423-426. 4 April 1991

Major histocompatibility complex class II hyperexpression on B cells in interleukin 4-transgenic mice does not lead to B cell proliferation and hypergammaglobulinemia.
Müller, W., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803 and Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
European Journal of Immunology 21 (4): 921-925. April 1991

Signal requirements for growth and differentiation of activated murine B lymphocytes.
Müller, W., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Goldmann, W., Tesch, H., Smith, F.I., Radbruch, A. and Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
Journal of Immunology 135 (2): 1213-1219. August 1985

Book Section

Genetisch veraenderte Tiere.
Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803 and Wurst, W.
In: Handbuch der Psychopharmakotherapie. Springer, 149-167. ISBN 978-3-642-19843-4 2012

Mouse mutagenesis and gene function.
Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803 and Wurst, W.
In: Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. Wiley, New York, U.S.A., 1184-1201. ISBN 978-0-470-84974-3 15 April 2005

Knock out mice models for immunodeficiency diseases.
Haas, W. and Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803
In: Progress in Immunology. Springer, 561-570 . ISBN 978-3-642-51481-4 1993

Book

TALENs : Methods and Protocols.
Kuehn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Wurst, W. and Wefers, B.
Methods in Molecular Biology, 1338 . Springer, New York. ISBN 978-1-4939-2931-3 2016

Gene knockout protocols.
Wurst, W. and Kuehn, R., eds.
Methods in Molecular Biology, 530 . Springer / Humana Press. ISBN 978-1-934115-26-8 2009

Laboratory protocols for conditional gene targeting.
Torres, R.M. and Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803
Oxford University Press. ISBN 0-19-963677-X 1997

Review

Novel human neurodevelopmental and neurodegenerative disease associated with IRF2BPL gene variants-mechanisms and therapeutic avenues.
Bauersachs, D., Bomholtz, L., Del Ray Mateos, S., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803 and Lisowski, P. ORCID: https://orcid.org/0000-0002-3634-1072
Frontiers in Neuroscience 18 : 1426177. 6 June 2024

Genome wide conditional mouse knockout resources.
Kaloff, C., Anastassiadis, K., Ayadi, A., Baldock, R., Beig, J., Birling, M.C., Bradley, A., Brown, S.D.M., Buerger, A., Bushell, W., Chiani, F., Collins, F.S., Doe, B., Eppig, J.T., Finnell, R.H., Fletcher, C., Flicek, P., Fray, M., Friedel, R.H., Gambadoro, A., Gates, H., Hansen, J., Herault, Y., Hicks, G.G., Hoerlein, A., Hrabe de Angelis, M., Iyer, V., de Jong, P.J., Koscielny, G., Kuehn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Liu, P., Lloyd, K.C.K, Lopez, R.G., Marschall, S., Martinez, S., McKerlie, C., Meehan, T., von Melchner, H., Moore, M., Murray, S.A., Nagy, A., Nutter, L.M.J., Pavlovic, G., Pombero, A., Prosser, H., Ramirez-Solis, R., Ringwald, M., Rosen, B., Rosenthal, N., Rossant, J., Ruiz Noppinger, P., Ryder, E., Skarnes, W.C., Schick, J., Schnuetgen, F., Schofield, P., Seisenberger, C., Selloum, M., Smedley, D., Simpson, E.M., Stewart, A.F., Teboul, L., Tocchini Valentini, G.P., Valenzuela, D., West, A.P. and Wurst, W.
Drug Discovery Today: Disease Models 20 : 3-12. 2016

Conditional RNAi in mice.
Kleinhammer, A., Deussing, J., Wurst, W. and Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803
Methods 53 (2): 142-150. February 2011

Gene knockdown in the mouse through RNAi.
Kleinhammer, A., Wurst, W. and Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803
Methods in Enzymology 477 : 387-414. 2010

The functional annotation of mammalian genomes: the challenge of phenotyping.
Brown, S.D.M., Wurst, W., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803 and Hancock, J.M.
Annual Review of Genetics 43 : 305-333. December 2009

RNA interference in mice.
Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Streif, S. and Wurst, W.
Handbook of Experimental Pharmacology 178 (1): 149-176. 2007

Advances in gene targeting methods.
Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803 and Schwenk, F.
Current Opinion in Immunology 9 (2): 183-188. April 1997

Common cytokine receptor gamma chain (gamma c)-dependent cytokines: understanding in vivo functions by gene targeting.
Di Santo, J.P., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803 and Mueller, W.
Immunological Reviews 148 (1): 19-34. December 1995

Editorial

A resource of targeted mutant mouse lines for 5,061 genes.
Birling, M.C., Yoshiki, A. ORCID: https://orcid.org/0000-0002-9450-5151, Adams, D.J. ORCID: https://orcid.org/0000-0001-9490-0306, Ayabe, S. ORCID: https://orcid.org/0000-0003-2737-5315, Beaudet, A.L., Bottomley, J., Bradley, A., Brown, S.D.M., Bürger, A., Bushell, W., Chiani, F. ORCID: https://orcid.org/0000-0002-8887-3900, Chin, H.J.G., Christou, S., Codner, G.F., DeMayo, F.J., Dickinson, M.E., Doe, B., Donahue, L.R., Fray, M.D., Gambadoro, A., Gao, X., Gertsenstein, M., Gomez-Segura, A., Goodwin, L.O., Heaney, J.D., Hérault, Y. ORCID: https://orcid.org/0000-0001-7049-6900, de Angelis, M.H. ORCID: https://orcid.org/0000-0002-7898-2353, Jiang, S.T., Justice, M.J. ORCID: https://orcid.org/0000-0003-3562-2099, Kasparek, P., King, R.E. ORCID: https://orcid.org/0000-0001-6733-8805, Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Lee, H., Lee, Y.J. ORCID: https://orcid.org/0000-0002-3841-1994, Liu, Z., Lloyd, K.C.K. ORCID: https://orcid.org/0000-0002-5318-4144, Lorenzo, I., Mallon, A.M., McKerlie, C. ORCID: https://orcid.org/0000-0002-2232-0967, Meehan, T.F., Fuentes, V.M. ORCID: https://orcid.org/0000-0003-3574-546X, Newman, S., Nutter, L.M.J. ORCID: https://orcid.org/0000-0001-9619-146X, Oh, G.T. ORCID: https://orcid.org/0000-0002-1104-1698, Pavlovic, G. ORCID: https://orcid.org/0000-0001-9122-4592, Ramirez-Solis, R., Rosen, B., Ryder, E.J., Santos, L.A., Schick, J. ORCID: https://orcid.org/0000-0002-8623-4910, Seavitt, J.R., Sedlacek, R. ORCID: https://orcid.org/0000-0002-3352-392X, Seisenberger, C., Seong, J.K., Skarnes, W.C., Sorg, T., Steel, K.P., Tamura, M., Tocchini-Valentini, G.P., Wang, C.K.L., Wardle-Jones, H., Wattenhofer-Donzé, M. ORCID: https://orcid.org/0000-0002-6092-274X, Wells, S., Wiles, M.V., Willis, B.J., Wood, J.A., Wurst, W., Xu, Y. ORCID: https://orcid.org/0000-0002-6689-7768, Teboul, L. ORCID: https://orcid.org/0000-0002-2789-8637 and Murray, S.A. ORCID: https://orcid.org/0000-0002-0594-1702
Nature Genetics 53 (4): 416-419. April 2021

A novel allele for inducible Cre expression in germinal center B cells.
Weber, T. ORCID: https://orcid.org/0000-0003-2079-842X, Seagal, J., Winkler, W. ORCID: https://orcid.org/0000-0001-8807-9259, Wirtz, T. ORCID: https://orcid.org/0009-0005-5677-9804, Chu, V.T. ORCID: https://orcid.org/0000-0003-1327-8696 and Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
European Journal of Immunology 49 (1): 192-194. January 2019

Enhanced precision and efficiency.
Bashir, S. ORCID: https://orcid.org/0000-0002-1281-8710 and Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803
Nature Biomedical Engineering 1 (11): 856-857. November 2017

Pop in, pop out: a novel gene-targeting strategy for use with CRISPR-Cas9.
Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803 and Chu, V.T. ORCID: https://orcid.org/0000-0003-1327-8696
Genome Biology 16 (1): 244. 10 November 2015

Editing and investigating genomes with TALE and CRISPR/Cas systems: Genome engineering across species using TALENs.
Kuehn, R. ORCID: https://orcid.org/0000-0003-1694-9803 and Wefers, B.
Methods 69 (1): 1. 15 August 2014

Gene targeting in immunology.
Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803 and Müller, W.
Research in Immunology 148 (7): 447-449. September 1997

Conditional gene targeting.
Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370, Gu, H., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Betz, U.A., Müller, W., Roes, J. and Schwenk, F.
Journal of Clinical Investigation 98 (3): 600-603. 1 August 1996

Comment

Resistance to murine acquired immunodeficiency syndrome (MAIDS).
Morawetz, R.A., Doherty, T.M., Giese, N.A., Hartley, J.W., Müller, W., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370, Coffman, R. and Morse, H.C.
Science 265 (5169): 264-266. 8 July 1994

Induction of interleukin 4 (IL-4) expression in T helper (Th) cells is not dependent on IL-4 from non-Th cells.
Schmitz, J., Thiel, A., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370, Müller, W., Assenmacher, M. and Radbruch, A.
Journal of Experimental Medicine 179 (4): 1349-53. 1 April 1994

Development and proliferation of lymphocytes in mice deficient for both interleukins-2 and -4.
Sadlack, B., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Schorle, H., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370, Müller, W. and Horak, I.
European Journal of Immunology 24 (1): 281-284. January 1994

Interleukin-4 transgenic mice of resistant background are susceptible to Leishmania major infection.
Leal, L.M.C.C., Moss, D.W., Kuhn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Müller, W. and Liew, F.Y.
European Journal of Immunology 23 (2): 566-569. February 1993

Preprint

A non-viral CRISPR/Cas9 HDR platform for stable engineering of solid tumor models.
Afzal, Shoaib ORCID: https://orcid.org/0009-0009-5490-6098, Pilgram, Maximilian, Macos, Julia, Ohlendorf, Emily, Raab, Lena Olivia, Kath, Jonas, Glaser, Viktor, Nitulescu, Ana-Maria, van der Ven, Casper F.T., Lachiheb, Chahrazad, Stecklum, Maria, Drzeniek, Norman Michael ORCID: https://orcid.org/0000-0001-6562-2351, Anders, Kathleen ORCID: https://orcid.org/0000-0002-0429-200X, Wagner, Dimitrios Laurin, Kühn, Ralf ORCID: https://orcid.org/0000-0003-1694-9803, Künkele, Annette and Launspach, Michael ORCID: https://orcid.org/0000-0001-5337-5605
bioRxiv : 2026.06.01.729035. 4 June 2026

Novel mouse reporter models for the detection of genome editing events in vivo.
Snow, Kathy J. ORCID: https://orcid.org/0009-0006-5565-0619, Saville, Ethan ORCID: https://orcid.org/0009-0001-6564-5753, Heffner, Caleb ORCID: https://orcid.org/0000-0002-2631-6201, Gaitan, Yaned ORCID: https://orcid.org/0009-0002-4356-1812, Duryea, Jeffrey ORCID: https://orcid.org/0000-0001-7692-9340, Davis, Tiffany L. ORCID: https://orcid.org/0009-0001-3643-9977, Bechtel, Lawrence, Hannigan, Seth ORCID: https://orcid.org/0009-0004-7521-7439, Low, Benjamin E. ORCID: https://orcid.org/0000-0003-0350-4602, Rossius, Jana ORCID: https://orcid.org/0009-0000-6011-9714, Dang, Tu ORCID: https://orcid.org/0009-0001-0138-7599, Kulhankova, Katarina ORCID: https://orcid.org/0000-0001-7189-2323, Cheng, Anna X. ORCID: https://orcid.org/0000-0003-1727-9485, Wiles, Michael V. ORCID: https://orcid.org/0000-0002-3620-8386, Wurst, Wolfgang ORCID: https://orcid.org/0000-0003-4422-7410, McCray, Paul B. ORCID: https://orcid.org/0000-0002-4067-577X, Guay, David ORCID: https://orcid.org/0000-0003-0508-1703, Lutz, Cathleen M. ORCID: https://orcid.org/0000-0003-2502-1900, Bergstrom, David E. ORCID: https://orcid.org/0000-0003-0352-5411, Kuehn, Ralf ORCID: https://orcid.org/0000-0003-1694-9803 and Murray, Stephen A. ORCID: https://orcid.org/0000-0002-0594-1702
bioRxiv : 2026.04.29.721708. 2 May 2026

Targeted H3K9 acetylation at lncSox1 promoter by cell type-specific epigenome editing promotes intermediate progenitor proliferation in developing mouse cortex.
Sokpor, Godwin ORCID: https://orcid.org/0000-0002-7120-0793, Ulmke, P.A. ORCID: https://orcid.org/0000-0001-6960-9859, Nguyen, H.D., Pham, L., Kakani, P., Chu, V.T. ORCID: https://orcid.org/0000-0003-1327-8696, Arnold, S.J. ORCID: https://orcid.org/0000-0002-2688-9210, Brand-Saberi, B. ORCID: https://orcid.org/0000-0003-3309-9724, Nguyen, H.P. and Tuoc, T. ORCID: https://orcid.org/0000-0003-2079-7259
bioRxiv : 2024.11.05.621758. 5 November 2024

Dataset

Human sample from Homo sapiens.
Roman, Alexandra ORCID: https://orcid.org/0000-0001-9440-9752
[Dataset] 2 July 2025 (Submitted)

Human sample from Homo sapiens.
Roman, Alexandra ORCID: https://orcid.org/0000-0001-9440-9752
[Dataset] 2 July 2025 (Submitted)

Human sample from Homo sapiens.
Roman, Alexandra ORCID: https://orcid.org/0000-0001-9440-9752
[Dataset] 2 July 2025 (Submitted)

Human sample from Homo sapiens.
Roman, Alexandra ORCID: https://orcid.org/0000-0001-9440-9752
[Dataset] 2 July 2025 (Submitted)

Human sample from Homo sapiens.
Roman, Alexandra ORCID: https://orcid.org/0000-0001-9440-9752
[Dataset] 2 July 2025 (Submitted)

Human sample from Homo sapiens.
Roman, Alexandra ORCID: https://orcid.org/0000-0001-9440-9752
[Dataset] 2 July 2025 (Submitted)

Human sample from Homo sapiens.
Roman, Alexandra ORCID: https://orcid.org/0000-0001-9440-9752
[Dataset] 2 July 2025 (Submitted)

Human sample from Homo sapiens.
Roman, Alexandra ORCID: https://orcid.org/0000-0001-9440-9752
[Dataset] 2 July 2025 (Submitted)

Human sample from Homo sapiens.
Roman, Alexandra ORCID: https://orcid.org/0000-0001-9440-9752
[Dataset] 2 July 2025 (Submitted)

Human sample from Homo sapiens.
Roman, Alexandra ORCID: https://orcid.org/0000-0001-9440-9752
[Dataset] 2 July 2025 (Submitted)

Human sample from Homo sapiens.
Roman, Alexandra ORCID: https://orcid.org/0000-0001-9440-9752
[Dataset] 2 July 2025 (Submitted)

Human sample from Homo sapiens.
Roman, Alexandra ORCID: https://orcid.org/0000-0001-9440-9752
[Dataset] 2 July 2025 (Submitted)

Human sample from Homo sapiens.
Roman, Alexandra ORCID: https://orcid.org/0000-0001-9440-9752
[Dataset] 2 July 2025 (Submitted)

Human sample from Homo sapiens.
Roman, Alexandra ORCID: https://orcid.org/0000-0001-9440-9752
[Dataset] 2 July 2025 (Submitted)

Human sample from Homo sapiens.
Roman, Alexandra ORCID: https://orcid.org/0000-0001-9440-9752
[Dataset] 2 July 2025 (Submitted)

Mutant Huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure.
Lisowski, Pawel ORCID: https://orcid.org/0000-0002-3634-1072
[Dataset] 27 September 2024

Sex-determining 3D regulatory hubs revealed by genome spatial auto-correlation analysis.
Mota-Gómez, I. ORCID: https://orcid.org/0000-0001-8308-8017, Rodriguez, J.A., Dupont, S., Hurtado, A. ORCID: https://orcid.org/0000-0001-6267-704X, Cadenas, V., Lao, O., Jedamzick, J., Kuhn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Lacadie, S. ORCID: https://orcid.org/0000-0002-0893-5340, Garcia-Moreno, S.A., Torres, M., Real, F.M. ORCID: https://orcid.org/0000-0003-0692-2260, Acemel, R.D. ORCID: https://orcid.org/0000-0003-4120-0140, Capel, B., Marti-Renom, M.A. and Lupiañez, D.G. ORCID: https://orcid.org/0000-0002-3165-036X
[Dataset] 21 November 2022

iPSC-derived 2D and 3D models of mitochondrial disease reveal early defects in neuronal morphogenesis and identify intervention strategies.
Inak, G., Rybak, A. ORCID: https://orcid.org/0000-0002-1192-5290, Lisowski, P. ORCID: https://orcid.org/0000-0002-3634-1072, Pentimalli, T.M. ORCID: https://orcid.org/0000-0002-8461-7918, Karaiskos, N. ORCID: https://orcid.org/0000-0001-7771-3947, Rajewsky, N. ORCID: https://orcid.org/0000-0002-4785-4332, Schuelke, M. ORCID: https://orcid.org/0000-0003-2824-3891 and Prigione, A. ORCID: https://orcid.org/0000-0001-9457-1952
[Dataset] 20 April 2021