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2018

Mutations in disordered regions can cause disease by creating dileucine motifs.
Meyer, K. and Kirchner, M. and Uyar, B. and Cheng, J.Y. and Russo, G. and Hernandez-Miranda, L.R. and Szymborska, A. and Zauber, H. and Rudolph, I.M. and Willnow, T.E. and Akalin, A. and Haucke, V. and Gerhardt, H. and Birchmeier, C. and Kühn, R. and Krauss, M. and Diecke, S. and Pascual, J.M. and Selbach, M.
Cell 6 September 2018 (In Press)

Identification of genetic elements in metabolism by high-throughput mouse phenotyping.
Rozman, J. and Rathkolb, B. and Oestereicher, M.A. and Schütt, C. and Ravindranath, A.C. and Leuchtenberger, S. and Sharma, S. and Kistler, M. and Willershäuser, M. and Brommage, R. and Meehan, T.F. and Mason, J. and Haselimashhadi, H. and Hough, T. and Mallon, A.M. and Wells, S. and Santos, L. and Lelliott, C.J. and White, J.K. and Sorg, T. and Champy, M.F. and Bower, L.R. and Reynolds, C. L. and Flenniken, A.M. and Murray, St.A. and Nutter, L.M.J. and Svenson, K.L. and West, D. and Tocchini-Valentini, G.P. and Beaudet, A.L. and Bosch, F. and Braun, R.B. and Dobbie, M.S. and Gao, X. and Herault, Y. and Moshiri, A. and Moore, B.A. and Kent Lloyd, K.C. and McKerlie, C. and Masuya, H. and Tanaka, N. and Flicek, P. and Parkinson, H.E. and Sedlacek, R. and Seong, J.K. and Wang, C.K.L. and Moore, M. and Brown, S.D. and Tschöp, M.H. and Wurst, W. and Klingenspor, M. and Wolf, E. and Beckers, J. and Machicao, F. and Peter, A. and Staiger, H. and Häring, H.U. and Grallert, H. and Campillos, M. and Maier, H. and Fuchs, H. and Gailus-Durner, V. and Werner, T. and Hrabe de Angelis, M.
Nature Communications 9 (1): 288. 18 January 2018

2017

Enhanced precision and efficiency.
Bashir, S. and Kühn, R.
Nature Biomedical Engineering 1 (11): 856-857. November 2017

A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction.
Bowl, M.R. and Simon, M.M. and Ingham, N.J. and Greenaway, S. and Santos, L. and Cater, H. and Taylor, S. and Mason, J. and Kurbatova, N. and Pearson, S. and Bower, L.R. and Clary, D.A. and Meziane, H. and Reilly, P. and Minowa, O. and Kelsey, L. and Tocchini-Valentini, G.P. and Gao, X. and Bradley, A. and Skarnes, W.C. and Moore, M. and Beaudet, A.L. and Justice, M.J. and Seavitt, J. and Dickinson, M.E. and Wurst, W. and Hrabe de Angelis, M. and Herault, Y. and Wakana, S. and Nutter, L.M.J. and Flenniken, A.M. and McKerlie, C. and Murray, S.A. and Svenson, K.L. and Braun, R.E. and West, D.B. and Lloyd, K.C.K. and Adams, D.J. and White, J. and Karp, N. and Flicek, P. and Smedley, D. and Meehan, T.F. and Parkinson, H.E. and Teboul, L.M. and Wells, S. and Steel, K.P. and Mallon, A.M. and Brown, S.D.M.
Nature Communications 8 (1): 886. 12 October 2017

Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function.
Piwecka, M. and Glažar, P. and Hernandez-Miranda, L.R. and Memczak, S. and Wolf, S.A. and Rybak-Wolf, A. and Filipchyk, A. and Klironomos, F. and Cerda Jara, C.A. and Fenske, P. and Trimbuch, T. and Zywitza, V. and Plass, M. and Schreyer, L. and Ayoub, S. and Kocks, C. and Kühn, R. and Rosenmund, C. and Birchmeier, C. and Rajewsky, N.
Science 357 (6357): eaam8526. 22 September 2017

Elevated glutaric acid levels in Dhtkd1-/Gcdh- double knockout mice challenge our current understanding of lysine metabolism.
Biagosch, C. and Ediga, R.D. and Hensler, S.V. and Faerberboeck, M. and Kuehn, R. and Wurst, W. and Meitinger, T. and Kölker, S. and Sauer, S. and Prokisch, H.
Biochimica et Biophysica Acta - Molecular Basis of Disease 1863 (9): 2220-2228. September 2017

Control of gene editing by manipulation of DNA repair mechanisms.
Danner, E. and Bashir, S. and Yumlu, S. and Wurst, W. and Wefers, B. and Kühn, R.
Mammalian Genome 28 (7-8): 262-274. August 2017

Gene editing and clonal isolation of human induced pluripotent stem cells using CRISPR/Cas9.
Yumlu, S. and Stumm, J. and Bashir, S. and Dreyer, A.K. and Lisowski, P. and Danner, E. and Kühn, R.
Methods 121-122 : 29-44. 15 May 2017

Gene editing in mouse zygotes using the CRISPR/Cas9 system.
Wefers, B. and Bashir, S. and Rossius, J. and Kühn, R.
Methods 121-122 : 55-67. 15 May 2017

Fusion of SpCas9 to E.coli Rec A protein enhances CRISPR-Cas9 mediated gene knockout in mammalian cells.
Lin, L. and Petersen, T.S. and Jensen, K.T. and Bolund, L. and Kühn, R. and Luo, Y.
Journal of Biotechnology 247 : 42-49. 10 April 2017

2016

Caspase-mediated apoptosis induction in zebrafish cerebellar Purkinje neurons.
Weber, T. and Namikawa, K. and Winter, B. and Müller-Brown, K. and Kühn, R. and Wurst, W. and Köster, R.W.
Development 143 (22): 4279-4287. 15 November 2016

Efficient CRISPR-mediated mutagenesis in primary immune cells using CrispRGold and a C57BL/6 Cas9 transgenic mouse line.
Chu, V.T. and Graf, R. and Wirtz, T. and Weber, T. and Favret, J. and Li, X. and Petsch, K. and Tran, N.T. and Sieweke, M.H. and Berek, C. and Kühn, R. and Rajewsky, K.
Proceedings of the National Academy of Sciences of the United States of America 113 (44): 12514-12519. 1 November 2016

Efficient generation of Rosa26 knock-in mice using CRISPR/Cas9 in C57BL/6 zygotes.
Chu, V.T. and Weber, T. and Graf, R. and Sommermann, T. and Petsch, K. and Sack, U. and Volchkov, P. and Rajewsky, K. and Kühn, R.
BMC Biotechnology 16 (1): 4. 16 January 2016

Genome editing in mice using TALE nucleases.
Wefers, B. and Brandl, C. and Ortiz, O. and Wurst, W. and Kühn, R.
Methods in Molecular Biology 1338 : 229-243. 2016

Genome wide conditional mouse knockout resources.
Kaloff, C. and Anastassiadis, K. and Ayadi, A. and Baldock, R. and Beig, J. and Birling, M.C. and Bradley, A. and Brown, S.D.M. and Buerger, A. and Bushell, W. and Chiani, F. and Collins, F.S. and Doe, B. and Eppig, J.T. and Finnell, R.H. and Fletcher, C. and Flicek, P. and Fray, M. and Friedel, R.H. and Gambadoro, A. and Gates, H. and Hansen, J. and Herault, Y. and Hicks, G.G. and Hoerlein, A. and Hrabe de Angelis, M. and Iyer, V. and de Jong, P.J. and Koscielny, G. and Kuehn, R. and Liu, P. and Lloyd, K.C.K and Lopez, R.G. and Marschall, S. and Martinez, S. and McKerlie, C. and Meehan, T. and von Melchner, H. and Moore, M. and Murray, S.A. and Nagy, A. and Nutter, L.M.J. and Pavlovic, G. and Pombero, A. and Prosser, H. and Ramirez-Solis, R. and Ringwald, M. and Rosen, B. and Rosenthal, N. and Rossant, J. and Ruiz Noppinger, P. and Ryder, E. and Skarnes, W.C. and Schick, J. and Schnuetgen, F. and Schofield, P. and Seisenberger, C. and Selloum, M. and Smedley, D. and Simpson, E.M. and Stewart, A.F. and Teboul, L. and Tocchini Valentini, G.P. and Valenzuela, D. and West, A.P. and Wurst, W.
Drug Discovery Today: Disease Models 20 : 3-12. 2016

TALENs : Methods and Protocols.
Kuehn, R. and Wurst, W. and Wefers, B.
Methods in Molecular Biology, 1338 . Springer, New York. ISBN 978-1-4939-2931-3 2016

2015

Conditional reduction of adult born doublecortin-positive neurons reversibly impairs selective behaviors.
Garrett, L. and Zhang, J. and Zimprich, A. and Niedermeier, K.M. and Fuchs, H. and Gailus-Durner, V. and Hrabe de Angelis, M. and Vogt Weisenhorn, D. and Wurst, W. and Hoelter, S.M.
Frontiers in Behavioral Neuroscience 9 : 302. 12 November 2015

Pop in, pop out: a novel gene-targeting strategy for use with CRISPR-Cas9.
Kühn, R. and Chu, V.T.
Genome Biology 16 (1): 244. 10 November 2015

Development of an intein-mediated split-Cas9 system for gene therapy.
Truong, D.J.J. and Kühner, K. and Kühn, R. and Werfel, S. and Engelhardt, S. and Wurst, W. and Ortiz, O.
Nucleic Acids Research 43 (13): 6450-6458. 27 July 2015

Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells.
Chu, V.T. and Weber, T. and Wefers, B. and Wurst, W. and Sander, S. and Rajewsky, K. and Kühn, R.
Nature Biotechnology 33 (5): 543-548. May 2015

Creation of targeted genomic deletions using TALEN or CRISPR/Cas nuclease pairs in one-cell mouse embryos.
Brandl, C. and Ortiz, O. and Röttig, B. and Wefers, B. and Wurst, W. and Kühn, R.
FEBS Open Bio 5 : 26-35. 2015

2014

Editing and investigating genomes with TALE and CRISPR/Cas systems: Genome engineering across species using TALENs.
Kuehn, R. and Wefers, B.
Methods 69 (1): 1. 15 August 2014

Generation of targeted mouse mutants by embryo microinjection of TALENs.
Wefers, B. and Ortiz, O. and Wurst, W. and Kühn, R.
Methods 69 (1): 94-101. 15 August 2014

Simple derivation of transgene-free iPS cells by a dual recombinase approach.
Pertek, A. and Meier, F. and Irmler, M. and Beckers, J. and Skylaki, S. and Endele, M. and Wurst, W. and Prakash, N. and Kühn, R.
Molecular Biotechnology 56 (8): 697-713. August 2014

FGF/FGFR2 signaling regulates the generation and correct positioning of Bergmann glia cells in the developing mouse cerebellum.
Meier, F. and Giesert, F. and Delic, S. and Faus-Kessler, T. and Matheus, F. and Simeone, A. and Hoelter, S.M. and Kühn, R. and Vogt-Weisenhorn, D.M. and Wurst, W. and Prakash, N.
PLoS ONE 9 (7): e101124. 1 July 2014

2013

Generation of targeted mouse mutants by embryo microinjection of TALEN mRNA.
Wefers, B. and Panda, S.K. and Ortiz, O. and Brandl, C. and Hensler, S. and Hansen, J. and Wurst, W. and Kühn, R.
Nature Protocols 8 (12): 2355-2379. December 2013

An RNAi-based approach to down-regulate a gene family in vivo.
Kim, J. and Badaloni, A. and Willert, T. and Zimber-Strobl, U. and Kühn, R. and Wurst, W. and Kieslinger, M.
PLoS ONE 8 (11): e80312. 12 November 2013

Highly efficient targeted mutagenesis in mice using TALENs.
Panda, S.K. and Wefers, B. and Ortiz, O. and Floss, T. and Schmid, B. and Haass, C. and Wurst, W. and Kühn, R.
Genetics 195 (3): 703-713. November 2013

Reversible and tissue-specific activation of MAP kinase signaling by tamoxifen in Braf(V637)ER(T2) mice.
Ortiz, O. and Wurst, W. and Kühn, R.
Genesis 51 (6): 448-455. June 2013

Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides.
Wefers, B. and Meyer, M. and Ortiz, O. and Hrabé de Angelis, M. and Hansen, J. and Wurst, W. and Kühn, R.
Proceedings of the National Academy of Sciences of the United States of America 110 (10): 3782-3787. 5 March 2013

Characterization of the melanocortin-4-receptor nonsense mutation W16X in vitro and in vivo.
Bolze, F. and Rink, N. and Brumm, H. and Kühn, R. and Mocek, S. and Schwarz, A.E. and Kless, C. and Biebermann, H. and Wurst, W. and Rozman, J. and Klingenspor, M.
Pharmacogenomics Journal 13 (1): 80-93. February 2013

Efficient generation of rat induced pluripotent stem cells using a non-viral inducible vector.
Merkl, C. and Saalfrank, A. and Riesen, N. and Kühn, R. and Pertek, A. and Eser, S. and Hardt, M.S. and Kind, A. and Saur, D. and Wurst, W. and Iglesias, A. and Schnieke, A.
PLoS ONE 8 (1): e55170. 31 January 2013

Target validation in mice by constitutive and conditional RNAi.
Kleinhammer, A. and Wurst, W. and Kühn, R.
Methods in Molecular Biology 986 : 307-323. 23 January 2013

2012

Gene editing in one-cell embryos by zinc-finger and TAL nucleases.
Wefers, B. and Meyer, M. and Hensler, S. and Panda, S. and Ortiz, O. and Wurst, W. and Kuehn, R.
Current Protocols in Mouse Biology 2 : 347-364. December 2012

In vivo functional requirement of the mouse Ifitm1 gene for germ cell development, interferon mediated immune response and somitogenesis.
Klymiuk, I. and Kenner, L. and Adler, T. and Busch, D.H. and Boersma, A. and Irmler, M. and Fridrich, B. and Gailus-Durner, V. and Fuchs, H. and Leitner, N. and Mueller, M. and Kuehn, R. and Schlederer, M. and Treise, I. and de Angelis, M.H. and Beckers, J.
PLoS ONE 7 (10): e44609. 24 October 2012

Humanized c-Myc mouse.
Lehmann, F.M. and Feicht, S. and Helm, F. and Maurberger, A. and Ladinig, C. and Zimber-Strobl, U. and Kuehn, R. and Mautner, J. and Gerbitz, A. and Bornkamm, G.W.
PLoS ONE 7 (7): e42021. 31 July 2012

Modeling disease mutations by gene targeting in one-cell mouse embryos.
Meyer, M. and Ortiz, O. and Hrabe de Angelis, M. and Wurst, W. and Kuehn, R.
Proceedings of the National Academy of Sciences of the United States of America 109 (24): 9354-9359. 12 June 2012

Pink1-deficiency in mice impairs gait, olfaction and serotonergic innervation of the olfactory bulb.
Glasl, L. and Kloos, K. and Giesert, F. and Roethig, A. and Di Benedetto, B. and Kuehn, R. and Zhang, J. and Hafen, U. and Zerle, J. and Hofmann, A. and de Angelis, M.H. and Winklhofer, K.F. and Hoelter, S.M. and Vogt Weisenhorn, D.M. and Wurst, W.
Experimental Neurology 235 (1): 214-227. May 2012

MAPK signaling determines anxiety in the juvenile mouse brain but depression-like behavior in adults.
Wefers, B. and Hitz, C. and Hoelter, S.M. and Truembach, D. and Hansen, J. and Weber, P. and Puetz, B. and Deussing, J.M. and de Angelis, M.H. and Roenneberg, T. and Zheng, F. and Alzheimer, C. and Silva, A. and Wurst, W. and Kuehn, R.
PLoS ONE 7 (4): e35035. 18 April 2012

N-desalkylquetiapine activates ERK1/2 to induce GDNF release in C6 glioma cells: a putative cellular mechanism for quetiapine as antidepressant.
Di Benedetto, B. and Kuehn, R. and Nothdurfter, C. and Rein, T. and Wurst, W. and Rupprecht, R.
Neuropharmacology 62 (1): 209-216. January 2012

Genetic models of Parkinson's disease.
Kuehn, R. and Vogt-Weisenhorn, D. and Wurst, W.
NeuroMethods 61 : 243-265. 2012

Genetisch veraenderte Tiere.
Kuehn, R. and Wurst, W.
In: Handbuch der Psychopharmakotherapie. Springer (Germany), 149-167. ISBN 978-3-642-19843-4 2012

2011

CD19-independent instruction of murine marginal zone B-cell development by constitutive Notch2 signaling.
Hampel, F. and Ehrenberg, S. and Hojer, C. and Draeseke, A. and Marschall-Schroeter, G. and Kuehn, R. and Mack, B. and Gires, O. and Vahl, C.J. and Schmidt-Supprian, M. and Strobl, L.J. and Zimber-Strobl, U.
Blood 118 (24): 6321-631. 8 December 2011

Design and generation of gene-targeting vectors.
Wefers, B. and Wurst, W. and Kuehn, R.
Current Protocols in Mouse Biology 1 : 199-211. March 2011

Generating conditional knockout mice.
Friedel, R.H. and Wurst, W. and Wefers, B. and Kuehn, R.
Methods in Molecular Biology 693 : 205-231. 2011

2010

Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases.
Meyer, M. and de Angelis, M.H. and Wurst, W. and Kuehn, R.
Proceedings of the National Academy of Sciences of the United States of America 107 (34): 15022-15026. 24 August 2010

Phenotypic annotation of the mouse X chromosome.
Cox, B.J. and Vollmer, M. and Tamplin, O. and Lu, M. and Biechele, S. and Gertsenstein, M. and van Campenhout, C. and Floss, T. and Kuehn, R. and Wurst, W. and Lickert, H. and Rossant, J.
Genome Research 20 (8): 1154-1164. August 2010

Gene knockdown in the mouse through RNAi.
Kleinhammer, A. and Wurst, W. and Kuehn, R.
Methods in Enzymology 477 : 387-414. 2010

2009

The functional annotation of mammalian genomes: the challenge of phenotyping.
Brown, S.D.M. and Wurst, W. and Kuehn, R. and Hancock, J.M.
Annual Review of Genetics 43 : 305-333. December 2009

Local knockdown of ERK2 in the adult mouse brain via adeno-associated virus-mediated RNA interference.
Di Benedetto, B. and Wefers, B. and Wurst, W. and Kuehn, R.
Molecular Biotechnology 41 (3): 263-269. March 2009

Gene knockout protocols.
Wurst, W. and Kuehn, R., eds.
Methods in Molecular Biology, 530 . Springer / Humana Press (U.S.A.). ISBN 978-1-934115-26-8 2009

Generation of shRNA transgenic mice.
Hitz, C. and Steuber-Buchberger, P. and Delic, S. and Wurst, W. and Kuehn, R.
Methods in Molecular Biology 530 : 101-129. 2009

Overview on mouse mutagenesis.
Kuehn, R. and Wurst, W.
Methods in Molecular Biology 530 : 1-12. 2009

2008

Genetic mouse models for behavioral analysis through transgenic RNAi technology.
Delic, S. and Streif, S. and Deussing, J.M. and Weber, P. and Ueffing, M. and Hoelter, S.M. and Wurst, W. and Kuehn, R.
Genes Brain and Behavior 7 (7): 821-830. October 2008

Novel caspase-suicide proteins for tamoxifen-inducible apoptosis.
Chu, Y. and Senghaas, N. and Koester, R.W. and Wurst, W. and Kuehn, R.
Genesis 46 (10): 530-536. October 2008

Sall4 isoforms act during proximal-distal and anterior-posterior axis formation in the mouse embryo.
Uez, N. and Lickert, H. and Kohlhase, J. and de Angelis, M.H. and Kuehn, R. and Wurst, W. and Floss, T.
Genesis 46 (9): 463-477. September 2008

Simultaneous Cre-mediated conditional knockdown of two genes in mice.
Steuber-Buchberger, P. and Wurst, W. and Kuehn, R.
Genesis 46 (3): 144-151. March 2008

2007

Conditional brain-specific knockdown of MAPK using Cre/loxP regulated RNA interference.
Hitz, C. and Wurst, W. and Kuehn, R.
Nucleic Acids Research 35 (12): e90. June 2007

Differential mRNA distribution of components of the ERK/MAPK signalling cascade in the adult mouse brain.
Di Benedetto, B. and Hitz, C. and Hoelter, S.M. and Kuehn, R. and Vogt Weisenhorn, D.M. and Wurst, W.
Journal of Comparative Neurology 500 (3): 542-556. 20 January 2007

Development of a species-specific RNA polymerase I-based shRNA expression vector.
Brenz Verca, M.S. and Weber, P. and Mayer, C. and Graf, C. and Refojo, D. and Kuehn, R. and Grummt, I. and Lutz, B.
Nucleic Acids Research 35 (2): e10. January 2007

RNA interference in mice.
Kuehn, R. and Streif, S. and Wurst, W.
Handbook of Experimental Pharmacology 178 (1): 149-176. 2007

2006

Inducible gene deletion in astroglia and radial glia--a valuable tool for functional and lineage analysis.
Mori, T. and Tanaka, K. and Buffo, A. and Wurst, W. and Kuehn, R. and Goetz, M.
Glia 54 (1): 21-34. July 2006

Forebrain-specific knockout of B-raf kinase leads to deficits in hippocampal long-term potentiation, learning, and memory.
Chen, A.P. and Ohno, M. and Giese, K.P. and Kuehn, R. and Chen, R.L. and Silva, A.J.
Journal of Neuroscience Research 83 (1): 28-38. January 2006

2005

Mouse mutagenesis and gene function.
Kuehn, R. and Wurst, W.
In: Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. Wiley (U.S.A.), New York, U.S.A., 1184-1201. ISBN 978-0-470-84974-3 15 April 2005

Single copy shRNA configuration for ubiquitous gene knockdown in mice.
Seibler, J. and Kueter-Luks, B. and Kern, H. and Streu, S. and Plum, L. and Mauer, J. and Kuehn, R. and Bruening, J.C. and Schwenk, F.
Nucleic Acids Research 33 (7): e67. 14 April 2005

2003

Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress.
Mueller, M.B. and Zimmermann, S. and Sillaber, I. and Hagemeyer, T.P. and Deussing, J.M. and Timpl, P. and Kormann, M.S.D. and Droste, S.K. and Kuehn, R. and Reul, J.M.H.M. and Holsboer, F. and Wurst, W.
Nature Neuroscience 6 (10): 1100-1107. October 2003

Connexin43 is not expressed in principal cells of mouse cortex and hippocampus.
Theis, M. and Soehl, G. and Speidel, D. and Kuehn, R. and Willecke, K.
European Journal of Neuroscience 18 (2): 267-274. July 2003

Hybrid embryonic stem cell-derived tetraploid mice show apparently normal morphological, physiological, and neurological characteristics.
Schwenk, F. and Zevnik, B. and Bruening, J. and Roehl, M. and Willuweit, A. and Rode, A. and Hennek, T. and Kauselmann, G. and Jaenisch, R. and Kuehn, R.
Molecular and Cellular Biology 23 (11): 3982-3989. June 2003

Rapid generation of inducible mouse mutants.
Seibler, J. and Zevnik, B. and Kueter-Luks, B. and Andreas, S. and Kern, H. and Hennek, T. and Rode, A. and Heimann, C. and Faust, N. and Kauselmann, G. and Schoor, M. and Jaenisch, R. and Rajewsky, K. and Kuehn, R. and Schwenk, F.
Nucleic Acids Research 31 (4): e12. 15 February 2003

Neuron-specific ablation of PDGF-B is compatible with normal central nervous system development and astroglial response to injury.
Enge, M. and Wilhelmsson, U. and Abramsson, A. and Stakeberg, J. and Kuehn, R. and Betsholtz, C. and Pekny, M.
Neurochemical Research 28 (2): 271-279. February 2003

2002

Enhanced efficiency through nuclear localization signal fusion on phage PhiC31-integrase: activity comparison with Cre and FLPe recombinase in mammalian cells.
Andreas, S. and Schwenk, F. and Kueter-Luks, B. and Faust, N. and Kuehn, R.
Nucleic Acids Research 30 (11): 2299-2306. 1 June 2002

Male and female mice derived from the same embryonic stem cell clone by tetraploid embryo complementation.
Eggan, K. and Rode, A. and Jentsch, I. and Samuel, C. and Hennek, T. and Tintrup, H. and Zevnik, B. and Erwin, J. and Loring, J. and Jackson-Grusby, L. and Speicher, M.R. and Kuehn, R. and Jaenisch, R.
Nature Biotechnology 20 (5): 455-459. May 2002

Conditional knockout mice.
Kuehn, R. and Schwenk, F.
Methods in Molecular Biology 209 : 159-185. 2002

Cre/loxP recombination system and gene targeting.
Kuehn, R. and Torres, R.M.
Methods in Molecular Biology 180 (5): 175-204. 2002

2001

Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity.
Rios, M. and Fan, G. and Fekete, C. and Kelly, J. and Bates, B. and Kuehn, R. and Lechan, R.M. and Jaenisch, R.
Molecular Endocrinology 15 (10): 1748-1757. October 2001

Actin pedestal formation by enteropathogenic Escherichia coli and intracellular motility of Shigella flexneri are abolished in N-WASP-defective cells.
Lommel, S. and Benesch, S. and Rottner, K. and Franz, T. and Wehland, J. and Kuehn, R.
EMBO Reports 2 (9): 850-857. September 2001

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics.
Roberds, S.L. and Anderson, J. and Basi, G. and Bienkowski, M.J. and Branstetter, D.G. and Chen, K.S. and Freedman, S.B. and Frigon, N.L. and Games, D. and Hu, K. and Johnson-Wood, K. and Kappenman, K.E. and Kawabe, T.T. and Kola, I. and Kuehn, R. and Lee, M. and Liu, W. and Motter, R. and Nichols, N.F. and Power, M. and Robertson, D.W. and Schenk, D. and Schoor, M. and Shopp, GM. and Shuck, M.E. and Sinha, S. and Svensson, K.A. and Tatsuno, G. and Tintrup, H. and Wijsman, J. and Wright, S. and McConlogue, L.
Human Molecular Genetics 10 (12): 1317-1324. 1 June 2001

DNA hypomethylation perturbs the function and survival of CNS neurons in postnatal animals.
Fan, G. and Beard, C. and Chen, R.Z. and Csankovszki, G. and Sun, Y. and Siniaia, M. and Biniszkiewicz, D. and Bates, B. and Lee, P.P. and Kuehn, R. and Trumpp, A. and Poon, C. and Wilson, C.B. and Jaenisch, R.
Journal of Neuroscience 21 (3): 788-797. 1 February 2001

1999

Essential role for TrkB receptors in hippocampus-mediated learning.
Minichiello, L. and Korte, M. and Wolfer, D. and Kuehn, R. and Unsicker, K. and Cestari, V. and Rossi-Arnaud, C. and Lipp, H.P. and Bonhoeffer, T. and Klein, R.
Neuron 24 (2): 401-414. October 1999

1998

Csk controls antigen receptor-mediated development and selection of T-lineage cells.
Schmedt, C. and Saijo, K. and Niidome, T. and Kuehn, R. and Aizawa, S. and Tarakhovsky, A.
Nature 394 (6696): 901-904. 27 August 1998

IL-10 regulates liver pathology in acute murine Schistosomiasis mansoni but is not required for immune down-modulation of chronic disease.
Wynn, T.A. and Cheever, A.W. and Williams, M.E. and Hieny, S. and Caspar, P. and Kuehn, R. and Mueller, W. and Sher, A.
Journal of Immunology 160 (9): 4473-4480. 1 May 1998

Temporally and spatially regulated somatic mutagenesis in mice.
Schwenk, F. and Kuehn, R. and Angrand, P.O. and Rajewsky, K. and Stewart, A.F.
Nucleic Acids Research 26 (6): 1427-1432. 15 March 1998

1997

Generation of Cre recombinase-specific monoclonal antibodies, able to characterize the pattern of Cre expression in cre-transgenic mouse strains.
Schwenk, F. and Sauer, B. and Kukoc, N. and Hoess, R. and Mueller, W. and Kocks, C. and Kuehn, R. and Rajewsky, K.
Journal of Immunological Methods 207 (2): 203-212. 24 September 1997

In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death.
Lam, K.P. and Kuehn, R. and Rajewsky, K.
Cell 90 (6): 1073-1083. 19 September 1997

Gene targeting in immunology.
Kuehn, R. and Mueller, W.
Research in Immunology 148 (7): 447-449. September 1997

Advances in gene targeting methods.
Kuehn, R. and Schwenk, F.
Current Opinion in Immunology 9 (2): 183-188. April 1997

Laboratory protocols for conditional gene targeting.
Torres, R.M. and Kuehn, R.
Oxford University Press (U.K.). ISBN 0-19-963677-X 1997

1996

Interleukin (IL)-4-independent immunoglobulin class switch to immunoglobulin (Ig)E in the mouse.
Morawetz, R.A. and Gabriele, L. and Rizzo, L.V. and Noben-Trauth, N. and Kuehn, R. and Rajewsky, K. and Mueller, W. and Doherty, T.M. and Finkelman, F. and Coffman, R.L. and Morse, H.C.
Journal of Experimental Medicine 184 (5): 1651-1661. 1 November 1996

Plasmodium chabaudi chabaudi: differential susceptibility of gene-targeted mice deficient in IL-10 to an erythrocytic-stage infection.
Linke, A and Kuehn, R. and Mueller, W and Honarvar, N and Li, C and Langhorne, J
Experimental Parasitology 84 (2): 253-263. November 1996

Impaired immunosuppressive response to ultraviolet radiation in interleukin-10-deficient mice.
Beissert, S. and Hosoi, J. and Kuehn, R. and Rajewsky, K. and Mueller, W. and Granstein, R.D.
Journal of Investigative Dermatology 107 (4): 553-557. October 1996

Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses.
Berg, D.J. and Davidson, N. and Kuehn, R. and Mueller, W. and Menon, S. and Holland, G. and Thompson-Snipes, L. and Leach, M.W. and Rennick, D.
Journal of Clinical Investigation 98 (4): 1010-1020. 15 August 1996

Conditional gene targeting.
Rajewsky, K. and Gu, H. and Kuehn, R. and Betz, U.A. and Mueller, W. and Roes, J. and Schwenk, F.
Journal of Clinical Investigation 98 (3): 600-603. 1 August 1996

Somatic hypermutation occurs in B cells of terminal deoxynucleotidyl transferase-, CD23-, interleukin-4-, IgD- and CD30-deficient mouse mutants.
Texido, G. and Jacobs, H. and Meiering, M. and Kuehn, R. and Roes, J. and Mueller, W. and Gilfillan, S. and Fujiwara, H. and Kikutani, H. and Yoshida, N. and Amakawa, R. and Benoist, C. and Mathis, D. and Kishimoto, T. and Mak, T.W. and Rajewsky, K.
European Journal of Immunology 26 (8): 1966-1969. August 1996

In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha.
Gazzinelli, R.T. and Wysocka, M. and Hieny, S. and Scharton-Kersten, T. and Cheever, A. and Kuehn, R. and Mueller, W. and Trinchieri, G. and Sher, A.
Journal of Immunology 157 (2): 798-805. 15 July 1996

T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice.
Davidson, N.J. and Leach, M.W. and Fort, M.M. and Thompson-Snipes, L. and Kuehn, R. and Mueller, W. and Berg, D.J. and Rennick, D.M.
Journal of Experimental Medicine 184 (1): 241-251. 1 July 1996

Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant mice.
Carrera, L. and Gazzinelli, R.T. and Badolato, R. and Hieny, S. and Mueller, W. and Kuehn, R. and Sacks, D.L.
Journal of Experimental Medicine 183 (2): 515-526. 1 February 1996

Requirement of mammalian DNA polymerase-beta in base-excision repair.
Sobol, R.W. and Horton, J.K. and Kuehn, R. and Gu, H. and Singhal, R.K. and Prasad, R. and Rajewsky, K. and Wilson, S.H.
Nature 379 (6561): 183-186. 11 January 1996

1995

Common cytokine receptor gamma chain (gamma c)-dependent cytokines: understanding in vivo functions by gene targeting.
Di Santo, J.P. and Kuehn, R. and Mueller, W.
Immunological Reviews 148 (1): 19-34. December 1995

Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance.
Berg, D.J. and Kuehn, R. and Rajewsky, K. and Mueller, W. and Menon, S. and Davidson, N. and Gruenig, G. and Rennick, D.
Journal of Clinical Investigation 96 (5): 2339-2347. November 1995

Inducible gene targeting in mice.
Kuehn, R. and Schwenk, F. and Aguet, M. and Rajewsky, K.
Science 269 (5229): 1427-1429. 8 September 1995

Antiviral immune responses in mice deficient for both interleukin-2 and interleukin-4.
Bachmann, M.F. and Schorle, H. and Kuehn, R. and Mueller, W. and Hengartner, H. and Zinkernagel, R.M. and Horak, I.
Journal of Virology 69 (8): 4842-4846. August 1995

Interleukin 10 but not interleukin 4 is a natural suppressant of cutaneous inflammatory responses.
Berg, D.J. and Leach, M.W. and Kuehn, R. and Rajewsky, K. and Mueller, W. and Davidson, N.J. and Rennick, D.
Journal of Experimental Medicine 182 (1): 99-108. 1 July 1995

1994

IL-9 production of naive CD4+ T cells depends on IL-2, is synergistically enhanced by a combination of TGF-beta and IL-4, and is inhibited by IFN-gamma.
Schmitt, E. and Germann, T. and Goedert, S. and Hoehn, P. and Huels, C. and Koelsch, S. and Kuehn, R. and Mueller, W. and Palm, N. and Ruede, E.
Journal of Immunology 153 (9): 3989-3996. 1 November 1994

MHC class I expression in mice lacking the proteasome subunit LMP-7.
Fehling, H.J. and Swat, W. and Laplace, C. and Kuehn, R. and Rajewsky, K. and Mueller, U. and von Boehmer, H.
Science 265 (5176): 1234-1237. 26 August 1994

Resistance to murine acquired immunodeficiency syndrome (MAIDS).
Morawetz, R.A. and Doherty, T.M. and Giese, N.A. and Hartley, J.W. and Mueller, W. and Kuehn, R. and Rajewsky, K. and Coffman, R. and Morse, H.C.
Science 265 (5169): 264-266. 8 July 1994

Induction of interleukin 4 (IL-4) expression in T helper (Th) cells is not dependent on IL-4 from non-Th cells.
Schmitz, J. and Thiel, A. and Kuehn, R. and Rajewsky, K. and Mueller, W. and Assenmacher, M. and Radbruch, A.
Journal of Experimental Medicine 179 (4): 1349-53. 1 April 1994

Development and proliferation of lymphocytes in mice deficient for both interleukins-2 and -4.
Sadlack, B. and Kuehn, R. and Schorle, H. and Rajewsky, K. and Mueller, W. and Horak, I.
European Journal of Immunology 24 (1): 281-284. January 1994

1993

Interleukin-10-deficient mice develop chronic enterocolitis.
Kuehn, R. and Loehler, J. and Rennick, D. and Rajewsky, K. and Mueller, W.
Cell 75 (2): 263-274. 22 October 1993

Interleukin-4-deficient mice.
Mueller, W and Rajewsky, K and Kuehn, R.
Research in Immunology 144 (8): 637-638. October 1993

Interleukin-4 transgenic mice of resistant background are susceptible to Leishmania major infection.
Leal, L.M.C.C. and Moss, D.W. and Kuhn, R. and Mueller, W. and Liew, F.Y.
European Journal of Immunology 23 (2): 566-569. February 1993

Knock out mice models for immunodeficiency diseases.
Haas, W. and Kuehn, R.
In: Progress in Immunology. Springer (Germany), 561-570 . ISBN 978-3-642-51481-4 1993

1992

T helper cell membranes promote IL-4-independent expression of germ-line Cγ1 transcripts in B cells.
Schultz, C.L. and Rothman, P. and Kuehn, R. and Kehry, M. and Mueller, W. and Rajewsky, K. and Alt, F. and Coffman, R.L.
Journal of Immunology 149 (1): 60-64. 1 July 1992

1991

Generation and analysis of interleukin-4 deficient mice.
Kuehn, R. and Rajewsky, K. and Mueller, W.
Science 254 (5032): 707-710. 1 November 1991

A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene.
Kitamura, D. and Roes, J. and Kuehn, R. and Rajewsky, K.
Nature 350 (6317): 423-426. 4 April 1991

Major histocompatibility complex class II hyperexpression on B cells in interleukin 4-transgenic mice does not lead to B cell proliferation and hypergammaglobulinemia.
Mueller, W. and Kuehn, R. and Rajewsky, K.
European Journal of Immunology 21 (4): 921-925. April 1991

1985

Signal requirements for growth and differentiation of activated murine B lymphocytes.
Mueller, W. and Kuehn, R. and Goldmann, W. and Tesch, H. and Smith, F.I. and Radbruch, A. and Rajewsky, K.
Journal of Immunology 135 (2): 1213-1219. August 1985

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