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2018

The AP-1-BATF and -BATF3 module is essential for growth, survival and TH17/ILC3 skewing of anaplastic large cell lymphoma.
Schleussner, N. and Merkel, O. and Costanza, M. and Liang, H.C. and Hummel, F. and Romagnani, C. and Durek, P. and Anagnostopoulos, I. and Hummel, M. and Jöhrens, K. and Niedobitek, A. and Griffin, P.R. and Piva, R. and Sczakiel, H.L. and Woessmann, W. and Damm-Welk, C. and Hinze, C. and Stoiber, D. and Gillissen, B. and Turner, S.D. and Kaergel, E. and von Hoff, L. and Grau, M. and Lenz, G. and Dörken, B. and Scheidereit, C. and Kenner, L. and Janz, M. and Mathas, S.
Leukemia 32 (9): 1994-2007. September 2018

Targeting the senescence-overriding cooperative activity of structurally unrelated H3K9 demethylases in melanoma.
Yu, Y. and Schleich, K. and Yue, B. and Ji, S. and Lohneis, P. and Kemper, K. and Silvis, M.S. and Qutob, N. and van Rooijen, E. and Werner-Klein, M. and Li, L. and Dhawan, D. and Meierjohann, S. and Reimann, M. and Elkahloun, A. and Treitschke, S. and Dörken, B. and Speck, C. and Mallette, F.A. and Zon, L.I. and Holmen, S.L. and Peeper, D.S. and Samuels, Y. and Schmitt, C.A. and Lee, S.
Cancer Cell 33 (2): 322-336. 12 February 2018

Senescence-associated reprogramming promotes cancer stemness.
Milanovic, M. and Fan, D.N.Y. and Belenki, D. and Däbritz, J.H.M. and Zhao, Z. and Yu, Y. and Dörr, J.R. and Dimitrova, L. and Lenze, D. and Monteiro Barbosa, I.A. and Mendoza-Parra, M.A. and Kanashova, T. and Metzner, M. and Pardon, K. and Reimann, M. and Trumpp, A. and Dörken, B. and Zuber, J. and Gronemeyer, H. and Hummel, M. and Dittmar, G. and Lee, S. and Schmitt, C.A.
Nature 553 (7686): 96-100. 4 January 2018

A transgenic dual-luciferase reporter mouse for longitudinal and functional monitoring of T cells in vivo.
Szyska, M. and Herda, S. and Althoff, S. and Heimann, A. and Russ, J. and D'Abundo, D. and Dang, T.M. and Durieux, I. and Dörken, B. and Blankenstein, T. and Na, I.K.
Cancer Immunology Research 6 (1): 110-120. January 2018

2017

Inactivation of the putative ubiquitin-E3 ligase PDLIM2 in classical Hodgkin and anaplastic large cell lymphoma.
Wurster, K.D. and Hummel, F. and Richter, J. and Giefing, M. and Hartmann, S. and Hansmann, M.L. and Kreher, S. and Köchert, K. and Krappmann, D. and Klapper, W. and Hummel, M. and Wenzel, S.S. and Lenz, G. and Janz, M. and Dörken, B. and Siebert, R. and Mathas, S.
Leukemia 31 (3): 602-613. March 2017

2016

Multiple myeloma cells modify VEGF/IL-6 levels and osteogenic potential of bone marrow stromal cells via Notch/miR-223.
Berenstein, R. and Nogai, A. and Waechter, M. and Blau, O. and Kuehnel, A. and Schmidt-Hieber, M. and Kunitz, A. and Pezzutto, A. and Dörken, B. and Blau, I.W.
Molecular Carcinogenesis 55 (12): 1927-1939. December 2016

BCR-ABL-positive acute myeloid leukemia: a new entity? Analysis of clinical and molecular features.
Neuendorff, N.R. and Burmeister, T. and Doerken, B. and Westermann, J.
Annals of Hematology 95 (8): 1211-1221. August 2016

CCL4 as an adjuvant for DNA vaccination in a Her2/neu mouse tumor model.
Nguyen-Hoai, T. and Pham-Duc, M. and Gries, M. and Dörken, B. and Pezzutto, A. and Westermann, J.
Cancer Gene Therapy 23 (6): 162-167. June 2016

Longitudinal study to assess the clinical significance of MSI2 expression in chronic myeloid keukemia patients.
Kaeda, J. and Ringel, F. and Oberender, C. and Gresse, M. and Amini, L. and Schwarz, M. and Doerken, B. and le Coutre, P.
Acta Haematologica 136 (1): 62-64. June 2016

Canonical NF-κB signaling is uniquely required for the long-term persistence of functional mature B cells.
Derudder, E. and Herzog, S. and Labi, V. and Yasuda, T. and Köchert, K. and Janz, M. and Villunger, A. and Schmidt-Supprian, M. and Rajewsky, K.
Proceedings of the National Academy of Sciences of the United States of America 113 (18): 5065-5070. 3 May 2016

DC generation from peripheral blood mononuclear cells in patients with chronic myeloid leukemia: Influence of interferons on DC yield and functional properties.
Floercken, A. and Kopp, J. and Kölsch, U. and Meisel, C. and Dörken, B. and Pezzutto, A. and Westermann, J.
Human Vaccines & Immunotherapeutics 12 (5): 1117-1123. 3 May 2016

CD20-targeting immunotherapy promotes cellular senescence in B-cell lymphoma.
Däbritz, J.H.M. and Yu, Y. and Milanovic, M. and Schönlein, M. and Rosenfeldt, M.T. and Dörr, J.R. and Kaufmann, A.M. and Dörken, B. and Schmitt, C.A.
Molecular Cancer Therapeutics 15 (5): 1074-1081. May 2016

Second-line treatment in pancreatic cancer patients: Who profits? Results from the CONKO study group.
Sinn, M. and Daelken, L. and Striefler, J.K. and Bischoff, S. and Schweitzer, N. and Pelzer, U. and Doerken, B. and Riess, H. and Stieler, J.M.
Pancreas 45 (4): 601-605. April 2016

A roadmap of constitutive NF-κB activity in Hodgkin lymphoma: dominant roles of p50 and p52 revealed by genome-wide analyses.
de Oliveira, K.A.P. and Kaergel, E. and Heinig, M. and Fontaine, J.F. and Patone, G. and Muro, E.M. and Mathas, S. and Hummel, M. and Andrade-Navarro, M.A. and Hübner, N. and Scheidereit, C.
Genome Medicine 8 (1): 28. 17 March 2016

Dysregulated development of IL-17-and IL-21-expressing follicular helper T cells and increased germinal center formation in the absence of RORγt.
Wichner, K. and Stauss, D. and Kampfrath, B. and Krüger, K. and Müller, G. and Rehm, A. and Lipp, M. and Höpken, U.E.
FASEB Journal 30 (2): 761-774. February 2016

2015

Frequent induction of chromosomal aberrations in in vivo skin fibroblasts after allogeneic stem cell transplantation: hints to chromosomal instability after irradiation.
Massenkeil, G. and Zschieschang, P. and Thiel, G. and Hemmati, P.G. and Budach, V. and Doerken, B. and Pross, J. and Arnold, R.
Radiation Oncology 10 : 266. 30 December 2015

Allogeneic stem cell transplantation for refractory acute myeloid leukemia: a single center analysis of long-term outcome.
Hemmati, P.G. and Terwey, T.H. and Na, I.K. and Jehn, C.F. and le Coutre, P. and Vuong, L.G. and Doerken, B. and Arnold, R.
European Journal of Haematology 95 (6): 498-506. December 2015

Myeloid-derived suppressor cells in human peripheral blood: optimized quantification in healthy donors and patients with metastatic renal cell carcinoma.
Flörcken, A. and Takvorian, A. and Singh, A. and Gerhardt, A. and Ostendorf, B.N. and Dörken, B. and Pezzutto, A. and Westermann, J.
Immunology Letters 168 (2): 260-267. December 2015

Apoptosis-susceptibility prolongs the lack of memory B cells in acute leukemic patients after allogeneic hematopoietic stem cell transplantation.
Mensen, A. and Oh, Y. and Becker, S.C. and Hemmati, P.G. and Jehn, C. and Westermann, J. and Szyska, M. and Göldner, H. and Dörken, B. and Scheibenbogen, C. and Arnold, R. and Na, I.K.
Biology of Blood and Marrow Transplantation 21 (11): 1895-1906. November 2015

Flow cytometric maturity score as a novel prognostic parameter in patients with acute myeloid leukemia.
Schneider, T. and Flörcken, A. and Singh, A. and Türkmen, S. and Burmeister, T. and Anagnostopoulos, I. and Pezzutto, A. and Dörken, B. and Westermann, J.
Annals of Hematology 94 (8): 1337-1345. August 2015

Anti-CD22 and anti-CD79B antibody drug conjugates are active in different molecular diffuse large B-cell lymphoma subtypes.
Pfeifer, M. and Zheng, B. and Erdmann, T. and Koeppen, H. and McCord, R. and Grau, M. and Staiger, A. and Chai, A. and Sandmann, T. and Madle, H. and Doerken, B. and Chu, Y.W. and Chen, A.I. and Lebovic, D. and Salles, G.A. and Czuczman, M.S. and Palanca-Wessels, M.C. and Press, O.W. and Advani, R. and Morschhauser, F. and Cheson, B.D. and Lenz, P. and Ott, G. and Polson, A.G. and Mundt, K.E. and Lenz, G.
Leukemia 29 (7): 1578-1586. July 2015

Up-regulated MSI2 is associated with more aggressive chronic myeloid leukemia.
Kaeda, J. and Ringel, F. and Oberender, C. and Mills, K. and Quintarelli, C. and Pane, F. and Koschmieder, S. and Slany, R. and Schwarzer, R. and Saglio, G. and Hemmati, P. and van Lessen, A. and Amini, L. and Greese, M. and Vagge, E. and Burmeister, T. and Serra, A. and Carson, A. and Schwarz, M. and Westermann, J. and Jundt, F. and Doerken, B. and le Coutre, P.
Leukemia & Lymphoma 56 (7): 2105-2113. July 2015

Efficacy of prophylactic low-molecular weight heparin for ambulatory patients with advanced pancreatic cancer: outcomes from the CONKO-004 trial.
Pelzer, U. and Opitz, B. and Deutschinoff, G. and Stauch, M. and Reitzig, P.C. and Hahnfeld, S. and Mueller, L. and Grunewald, M. and Stieler, J.M. and Sinn, M. and Denecke, T. and Bischoff, S. and Oettle, H. and Doerken, B. and Riess, H.
Journal of Clinical Oncology 33 (18): 2028-2034. 20 June 2015

The origins of ALK translocations.
Roukos, V. and Mathas, S.
Frontiers in Bioscience 7 : 260-268. 1 June 2015

Quantitative detection of DNMT3A R882H mutation in acute myeloid leukemia.
Berenstein, R. and Blau, I.W. and Suckert, N. and Baldus, C. and Pezzutto, A. and Dörken, B. and Blau, O.
Journal of Experimental & Clinical Cancer Research 34 (1): 55. 22 May 2015

Differential expression of SHP-1 in chronic myeloid leukemia.
Kaeda, J. and Neuman, D. and Bonecker, S. and Mills, K. and Oberender, C. and Amini, L. and Ringel, F. and Serra, A. and Schwarz, M. and Doerken, B. and Zalcberg, I. and Le Coutre, P.
Leukemia & Lymphoma 56 (5): 1547-1549. May 2015

Impact of early remission by induction therapy on allogeneic stem cell transplantation for acute myeloid leukemia with an intermediate risk karyotype in first complete remission.
Hemmati, P.G. and Terwey, T.H. and Na, I.K. and le Coutre, P. and Jehn, C.F. and Vuong, L.G. and Dörken, B. and Arnold, R.
European Journal of Haematology 94 (5): 431-438. May 2015

The IL-15 cytokine system provides growth and survival signals in hodgkin lymphoma and enhances the inflammatory phenotype of HRS cells.
Ullrich, K. and Blumenthal-Barby, F. and Lamprecht, B. and Koechert, K. and Lenze, D. and Hummel, M. and Mathas, S. and Doerken, B. and Janz, M.
Leukemia 29 (5): 1213-1218. May 2015

Gene expression profiling of peripheral blood mononuclear cells during treatment with a gene-modified allogeneic tumor cell vaccine in advanced renal cell cancer: tumor-induced immunosuppression and a possible role for NF-κB.
Flörcken, A. and Grau, M. and Wolf, A. and Weilemann, A. and Kopp, J. and Dörken, B. and Blankenstein, T. and Pezzutto, A. and Lenz, P. and Lenz, G. and Westermann, J.
International Journal of Cancer 136 (8): 1814-1826. 15 April 2015

Omission of dacarbazine or bleomycin, or both, from the ABVD regimen in treatment of early-stage favourable Hodgkin's lymphoma (GHSG HD13): an open-label, randomised, non-inferiority trial.
Behringer, K. and Goergen, H. and Hitz, F. and Zijlstra, J.M. and Greil, R. and Markova, J. and Sasse, S. and Fuchs, M. and Topp, M.S. and Soekler, M. and Mathas, S. and Meissner, J. and Wilhelm, M. and Koch, P. and Lindemann, H.W. and Schalk, E. and Semrau, R. and Kriz, J. and Vieler, T. and Bentz, M. and Lange, E. and Mahlberg, R. and Hassler, A. and Vogelhuber, M. and Hahn, D. and Mezger, J. and Krause, S.W. and Skoetz, N. and Böll, B. and von Tresckow, B. and Diehl, V. and Hallek, M. and Borchmann, P. and Stein, H. and Eich, H. and Engert, A.
Lancet 385 (9976): 1418-1427. 11 April 2015

Cytokine and proinflammatory gene expression in classical Hodgkin lymphoma: its more than NF-κB!
Kreher, S. and Cauchy, P. and Bonifer, C. and Mathas, S.
Cytokine 72 (1): 115-117. March 2015

Multiple myeloma cells alter the senescence phenotype of bone marrow mesenchymal stromal cells under participation of the DLK1-DIO3 genomic region.
Berenstein, R. and Blau, O. and Nogai, A. and Waechter, M. and Slonova, E. and Schmidt-Hieber, M. and Kunitz, A. and Pezzutto, A. and Doerken, B. and Blau, I.W.
BMC Cancer 15 (1): 68. 18 February 2015

Essential role of IRF4 and MYC signaling for survival of anaplastic large cell lymphoma.
Weilemann, A. and Grau, M. and Erdmann, T. and Merkel, O. and Sobhiafshar, U. and Anagnostopoulos, I. and Hummel, M. and Siegert, A. and Hayford, C. and Madle, H. and Wollert-Wulf, B. and Fichtner, I. and Dörken, B. and Dirnhofer, S. and Mathas, S. and Janz, M. and Emre, N.C.T. and Rosenwald, A. and Ott, G. and Lenz, P. and Tzankov, A. and Lenz, G.
Blood 125 (1): 124-132. 1 January 2015

BCR-ABL1 acute myeloid leukemia: clonal selection of a BCR-ABL1(-) subclone as a cause of refractory disease with nilotinib treatment.
Neuendorff, N.R. and Schwarz, M. and Hemmati, P. and Tuerkmen, S. and Bommer, C. and Burmeister, T. and Doerken, B. and le Coutre, P. and Arnold, R. and Westermann, J.
Acta Haematologica 133 (2): 237-241. 2015

2014

Access to follicular dendritic cells is a pivotal step in murine chronic lymphocytic leukemia B cell activation and proliferation.
Heinig, K. and Gätjen, M. and Grau, M. and Stache, V. and Anagnostopoulos, I. and Gerlach, K. and Niesner, R.A. and Cseresnyes, Z. and Hauser, A.E. and Lenz, P. and Hehlgans, T. and Brink, R. and Westermann, J. and Dörken, B. and Lipp, M. and Lenz, G. and Rehm, A. and Höpken, U.E.
Cancer Discovery 4 : 1448-1465. December 2014

Clinical lessons to be learned from patients developing chronic myeloid leukemia while on immunosuppressive therapy after solid organ transplantation: yet another dase after orthotopic heart transplantation.
Oberender, C. and Kleeberg, L. and Nienhues, N. and Gresse, M. and Doerken, B. and Riess, H. and le Coutre, P.
Case Reports in Hematology 2014 : 890438. 16 November 2014

α-smooth muscle actin expression and desmoplastic stromal reaction in pancreatic cancer: results from the CONKO-001 study.
Sinn, M. and Denkert, C. and Striefler, J.K. and Pelzer, U. and Stieler, J.M. and Bahra, M. and Lohneis, P. and Doerken, B. and Oettle, H. and Riess, H. and Sinn, B.V.
British Journal of Cancer 111 (10): 1917-1923. 11 November 2014

Mapping of transcription factor motifs in active chromatin identifies IRF5 as key regulator in classical Hodgkin lymphoma.
Kreher, S. and Bouhlel, M.A. and Cauchy, P. and Lamprecht, B. and Li, S. and Grau, M. and Hummel, F. and Köchert, K. and Anagnostopoulos, I. and Jöhrens, K. and Hummel, M. and Hiscott, J. and Wenzel, S.S. and Lenz, P. and Schneider, M. and Küppers, R. and Scheidereit, C. and Giefing, M. and Siebert, R. and Rajewsky, K. and Lenz, G. and Cockerill, P.N. and Janz, M. and Dörken, B. and Bonifer, C. and Mathas, S.
Proceedings of the National Academy of Sciences of the United States of America 111 (42): E4513-E4522. 21 October 2014

Comparison of chimerism and minimal residual disease monitoring for relapse prediction after allogeneic stem cell transplantation for adult acute lymphoblastic leukemia.
Terwey, T.H. and Hemmati, P.G. and Nagy, M. and Pfeifer, H. and Goekbuget, N. and Brueggemann, M. and Le Duc, T.M. and le Coutre, P. and Doerken, B. and Arnold, R.
Biology of Blood and Marrow Transplantation 20 (10): 1522-1529. October 2014

Dendritic cell-mediated survival signals in Eμ-Myc B-cell lymphoma depend on the transcription factor C/EBPβ.
Rehm, A. and Gätjen, M. and Gerlach, K. and Scholz, F. and Mensen, A. and Gloger, M. and Heinig, K. and Lamprecht, B. and Mathas, S. and Bégay, V. and Leutz, A. and Lipp, M. and Dörken, B. and Höpken, U.E.
Nature Communications 5 : 5057. 30 September 2014

Second-line oxaliplatin, folinic acid, and fluorouracil versus folinic acid and fluorouracil alone for gemcitabine-refractory pancreatic cancer : outcomes from the CONKO-003 trial.
Oettle, H. and Riess, H. and Stieler, J.M. and Heil, G. and Schwaner, I. and Seraphin, J. and Goerner, M. and Moelle, M. and Greten, T.F. and Lakner, V. and Bischoff, S. and Sinn, M. and Doerken, B. and Pelzer, U.
Journal of Clinical Oncology 32 (23): 2423-2429. 10 August 2014

High prevalence of immunoglobulin light chain gene aberrations as revealed by FISH in multiple myeloma and MGUS.
Tuerkmen, S. and Binder, A. and Gerlach, A. and Niehage, S. and Melissari, M.T. and Inandiklioglu, N. and Doerken, B. and Burmeister, T.
Genes Chromosomes & Cancer 53 (8): 650-656. August 2014

Notch pathway inhibition controls myeloma bone disease in the murine MOPC315.BM model.
Schwarzer, R. and Nickel, N. and Godau, J. and Willie, B.M. and Duda, G.N. and Schwarzer, R. and Cirovic, B. and Leutz, A. and Manz, R. and Bogen, B. and Dörken, B. and Jundt, F.
Blood Cancer Journal 4 : e217. 13 June 2014

SPARC expression in resected pancreatic cancer patients treated with Gemcitabine: results from the CONKO-001 study.
Sinn, M. and Sinn, B.V. and Striefler, J.K. and Lindner, J.L. and Stieler, J.M. and Lohneis, P. and Bischoff, S. and Blaeker, H. and Pelzer, U. and Neuhaus, P. and Dietel, M. and Doerken, B. and Oettle, H. and Riess, H. and Denkert, C.
Annals of Oncology 25 (5): 1025-1032. May 2014

Intensified chemotherapy and simultaneous treatment with heparin in outpatients with pancreatic cancer - the CONKO 004 pilot trial.
Pelzer, U. and Hilbig, A. and Stieler, J.M. and Bahra, M. and Sinn, M. and Gebauer, B. and Doerken, B. and Riess, H.
BMC Cancer 14 (1): 204. 19 March 2014

Peripheral blood sCD3(-) CD4(+) T cells: a useful diagnostic tool in angioimmunoblastic T cell lymphoma.
Singh, A. and Schabath, R. and Ratei, R. and Stroux, A. and Klemke, C.D. and Nebe, T. and Flörcken, A. and van Lessen, A. and Anagnostopoulos, I. and Dörken, B. and Ludwig, W.D. and Pezzutto, A. and Westermann, J.
Hematological Oncology 32 (1): 16-21. March 2014

Cytogenetic risk grouping by the monosomal karyotype classification is superior in predicting the outcome of acute myeloid leukemia undergoing allogeneic stem cell transplantation in complete remission.
Hemmati, P.G. and Schulze-Luckow, A. and Terwey, T.H. and le Coutre, P. and Vuong, L.G. and Doerken, B. and Arnold, R.
European Journal of Haematology 92 (2): 102-110. February 2014

Effects of Jak2 type 1 inhibitors NVP-BSK805 and NVP-BVB808 on Jak2 mutation-positive and Bcr-Abl-positive cell lines.
Ringel, F. and Kaeda, J. and Schwarz, M. and Oberender, C. and Grille, P. and Doerken, B. and Marque, F. and Manley, P.W. and Radimerski, T. and le Coutre, P.
Acta Haematologica 132 (1): 75-86. 31 January 2014

JAK2 V617F allele burden quantified by real time quantitative polymerase chain reaction and competitive polymerase chain reaction in patients with chronic myeloproliferative neoplasia.
Kaeda, J. and Bonamino, M. and Ayres-Silva, J. and Solza, C. and Ringel, F. and Blau, O. and Daumas, A. and Oberender, C. and Doerken, B. and Le Coutre, P. and Zalcberg, I.
Leukemia & Lymphoma 55 (1): 128-135. January 2014

Pharmacological and genomic profiling identifies NF-κB-targeted treatment strategies for mantle cell lymphoma.
Rahal, R. and Frick, M. and Romero, R. and Korn, J.M. and Kridel, R. and Chun Chan, F. and Meissner, B. and Bhang, H.E. and Ruddy, D. and Kauffmann, A. and Farsidjani, A. and Derti, A. and Rakiec, D. and Naylor, T. and Pfister, E. and Kovats, S. and Kim, S. and Dietze, K. and Doerken, B. and Steidl, C. and Tzankov, A. and Hummel, M. and Monahan, J. and Morrissey, M.P. and Fritsch, C. and Sellers, W.R. and Cooke, V.G. and Gascoyne, R.D. and Lenz, G. and Stegmeier, F.
Nature Medicine 20 (1): 87-92. January 2014

Transformation and additional malignancies are leading risk factors for an adverse course of disease in marginal zone lymphoma.
Meyer, A.H. and Stroux, A. and Lerch, K. and Eucker, J. and Eitle, J. and Hohloch, K. and Andrzejak, M. and Possinger, K. and Dörken, B. and Pezzutto, A. and Scholz, C.W.
Annals of Oncology 25 (1): 210-215. January 2014

2013

An individual patient-data comparison of combined modality therapy and ABVD alone for patients with limited-stage Hodgkin lymphoma.
Hay, A.E. and Klimm, B. and Chen, B.E. and Goergen, H. and Shepherd, L.E. and Fuchs, M. and Gospodarowicz, M.K. and Borchmann, P. and Connors, J.M. and Markova, J. and Crump, M. and Lohri, A. and Winter, J.N. and Doerken, B. and Pearcey, R.G. and Diehl, V. and Horning, S.J. and Eich, H.T. and Engert, A. and Meyer, R.M.
Annals of Oncology 24 (12): 3065-3069. December 2013

Transition from an autoimmune-prone state to fatal autoimmune disease in CCR7 and RORγt double-deficient mice is dependent on gut microbiota.
Wichner, K. and Fischer, A. and Winter, S. and Tetzlaff, S. and Heimesaat, M.M. and Bereswill, S. and Rehm, A. and Lipp, M. and Höpken, U.E.
Journal of Autoimmunity 47 : 58-72. December 2013

Does long-term survival in patients with pancreatic cancer really exist? Results from the CONKO-001 study.
Sinn, M. and Striefler, J.K. and Sinn, B.V. and Sallmon, D. and Bischoff, S. and Stieler, J.M. and Pelzer, U. and Bahra, M. and Neuhaus, P. and Doerken, B. and Denkert, C. and Riess, H. and Oettle, H.
Journal of Surgical Oncology 108 (6): 398-402. November 2013

Concurrent inhibition of PI3K and mTORC1/mTORC2 overcomes resistance to rapamycin induced apoptosis by down-regulation of Mcl-1 in mantle cell lymphoma.
Mueller, A. and Zang, C. and Chumduri, C. and Doerken, B. and Daniel, P.T. and Scholz, C.W.
International Journal of Cancer 133 (8): 1813-1824. 15 October 2013

IκB-ζ controls the constitutive NF-κB target gene network and survival of ABC DLBCL.
Nogai, H. and Wenzel, S.S. and Hailfinger, S. and Grau, M. and Kaergel, E. and Seitz, V. and Wollert-Wulf, B. and Pfeifer, M. and Wolf, A. and Frick, M. and Dietze, K. and Madle, H. and Tzankov, A. and Hummel, M. and Dörken, B. and Scheidereit, C. and Janz, M. and Lenz, P. and Thome, M. and Lenz, G.
Blood 122 (13): 2242-2250. 26 September 2013

Synthetic lethal metabolic targeting of cellular senescence in cancer therapy.
Dörr, J.R. and Yu, Y. and Milanovic, M. and Beuster, G. and Zasada, C. and Däbritz, J.H.M. and Lisec, J. and Lenze, D. and Gerhardt, A. and Schleicher, K. and Kratzat, S. and Purfürst, B. and Walenta, S. and Mueller-Klieser, W. and Gräler, M. and Hummel, M. and Keller, U. and Buck, A.K. and Dörken, B. and Willmitzer, L. and Reimann, M. and Kempa, S. and Lee, S. and Schmitt, C.A.
Nature 501 (7467): 421-425. 19 September 2013

Interventionally implanted port catheter systems for hepatic arterial infusion of chemotherapy in patients with primary liver cancer: a phase II-study (NCT00356161).
Sinn, M. and Nicolaou, A. and Ricke, J. and Podrabsky, P. and Seehofer, D. and Gebauer, B. and Pech, M. and Neuhaus, P. and Doerken, B. and Riess, H. and Hildebrandt, B.
BMC Gastroenterology 13 : 125. 9 August 2013

Hepatic arterial infusion with oxaliplatin and 5-FU/folinic acid for advanced biliary tract cancer: a phase II study.
Sinn, M. and Nicolaou, A. and Gebauer, B. and Podrabsky, P. and Seehofer, D. and Ricke, J. and Doerken, B. and Riess, H. and Hildebrandt, B.
Digestive Diseases and Sciences 58 (8): 2399-2405. August 2013

PTEN loss defines a PI3K/AKT pathway-dependent germinal center subtype of diffuse large B-cell lymphoma.
Pfeifer, M. and Grau, M. and Lenze, D. and Wenzel, S.S. and Wolf, A. and Wollert-Wulf, B. and Dietze, K. and Nogai, H. and Storek, B. and Madle, H. and Dörken, B. and Janz, M. and Dirnhofer, S. and Lenz, P. and Hummel, M. and Tzankov, A. and Lenz, G.
Proceedings of the National Academy of Sciences of the United States of America 110 (30): 12420-12425. 23 July 2013

Allogeneic partially HLA-matched dendritic cells pulsed with autologous tumor cell lysate as a vaccine in metastatic renal cell cancer: a clinical phase I/II study.
Flörcken, A. and Kopp, J. and van Lessen, A. and Movassaghi, K. and Takvorian, A. and Jöhrens, K. and Möbs, M. and Schönemann, C. and Sawitzki, B. and Egerer, K. and Dörken, B. and Pezzutto, A. and Westermann, J.
Human Vaccines & Immunotherapeutics 9 (7): 1217-1227. 1 June 2013

Anti-leukemia T cells in AML: TNF-α(+) CD8(+) T cells may escape detection and possibly reflect a stage of functional impairment.
Flörcken, A. and van Lessen, A. and Terwey, T.H. and Dörken, B. and Arnold, R. and Pezzutto, A. and Westermann, J.
Human Vaccines & Immunotherapeutics 9 (7): 1200-1204. 1 June 2013

MCL1 is deregulated in subgroups of diffuse large B-cell lymphoma.
Wenzel, S.S. and Grau, M. and Mavis, C. and Hailfinger, S. and Wolf, A. and Madle, H. and Deeb, G. and Doerken, B. and Thome, M. and Lenz, P. and Dirnhofer, S. and Hernandez-Ilizaliturri, F.J. and Tzankov, A. and Lenz, G.
Leukemia 27 (6): 1381-1390. June 2013

Value of carbohydrate antigen 19-9 in predicting response and therapy control in patients with metastatic pancreatic cancer undergoing first-line therapy.
Pelzer, U. and Hilbig, A. and Sinn, M. and Stieler, J. and Bahra, M. and Doerken, B. and Riess, H.
Frontiers in Oncology 3 : 155. June 2013

Blood group determinates incidence for pancreatic cancer in Germany.
Pelzer, U. and Klein, F. and Bahra, M. and Sinn, M. and Doerken, B. and Neuhaus, P. and Meyer, O. and Riess, H.
Frontiers in Physiology 4 : 118. 24 May 2013

NIH-defined graft-versus-host disease and evidence for a potent graft-versus-leukemia effect in patients with acute lymphoblastic leukemia.
Terwey, T.H. and Le Duc, T.M. and Hemmati, P.G. and le Coutre, P. and Nagy, M. and Martus, P. and Doerken, B. and Arnold, R.
Annals of Oncology 24 (5): 1363-1370. May 2013

Peripheral artery occlusive disease (PAOD) in chronic phase chronic myeloid leukemia patients treated with nilotinib or Imatinib.
Kim, T.D. and Rea, D. and Schwarz, M. and Grille, P. and Nicolini, F.E. and Rosti, G. and Levato, L. and Giles, F.J. and Dombret, H. and Mirault, T. and Labussiere, H. and Lindhorst, R. and Haverkamp, W. and Buschmann, I. and Doerken, B. and le Coutre, P.D.
Leukemia 27 (6): 1316-1321. 5 April 2013

Structural insights into the mechanism of GTPase activation in the GIMAP family.
Schwefel, D. and Arasu, B.S. and Marino, S.F. and Lamprecht, B. and Köchert, K. and Rosenbaum, E. and Eichhorst, J. and Wiesner, B. and Behlke, J. and Rocks, O. and Mathas, S. and Daumke, O.
Structure 21 (4): 550-559. 2 April 2013

2012

A novel mouse model for multiple myeloma (MOPC315.BM) that allows noninvasive spatiotemporal detection of osteolytic disease.
Hofgaard, P.O. and Jodal, H.C. and Bommert, K. and Huard, B. and Caers, J. and Carlsen, H. and Schwarzer, R. and Schuenemann, N. and Jundt, F. and Lindeberg, M.M. and Bogen, B.
PLoS ONE 7 (12): e51892. 20 December 2012

Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL.
Nagel, D. and Spranger, S. and Vincendeau, M. and Grau, M. and Raffegerst, S. and Kloo, B. and Hlahla, D. and Neuenschwander, M. and von Kries, J.P. and Hadian, K. and Doerken, B. and Lenz, P. and Lenz, G. and Schendel, D.J. and Krappmann, D.
Cancer Cell 22 (6): 825-837. 11 December 2012

HER2/neu DNA vaccination by intradermal gene delivery in a mouse tumor model: gene gun is superior to jet injector in inducing CTL responses and protective immunity.
Nguyen-Hoai, T. and Kobelt, D. and Hohn, O. and Vu, M.D. and Schlag, P.M. and Doerken, B. and Norley, S. and Lipp, M. and Walther, W. and Pezzutto, A. and Westermann, J.
OncoImmunology 1 (9): 1537-1545. 1 December 2012

CCL19 as an adjuvant for intradermal gene gun immunization in a Her2/neu mouse tumor model: improved vaccine efficacy and a role for B cells as APC.
Nguyen-Hoai, T. and Hohn, O. and Vu, M.D. and Baldenhofer, G. and Sayed Ahmed, M.S. and Doerken, B. and Norley, S. and Lipp, M. and Pezzutto, A. and Westermann, J.
Cancer Gene Therapy 19 (12): 880-887. December 2012

The sorting receptor sortilin exhibits a dual function in exocytic trafficking of interferon-γ and granzyme A in T cells.
Herda, S. and Raczkowski, F. and Mittruecker, H.W. and Willimsky, G. and Gerlach, K. and Kuehl, A.A. and Breiderhoff, T. and Willnow, T.E. and Doerken, B. and Hoepken, U.E. and Rehm, A.
Immunity 37 (5): 854-866. 16 November 2012

Homeostatic chemokines guide lymphoma cells to tumor growth-promoting niches within secondary lymphoid organs.
Hoepken, U.E. and Rehm, A.
Journal of Molecular Medicine 90 (11): 1237-1245. November 2012

The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers.
Calado, D.P. and Sasaki, Y. and Godinho, S.A. and Pellerin, A. and Köchert, K. and Sleckman, B.P. and de Alboran, I.M. and Janz, M. and Rodig, S. and Rajewsky, K.
Nature Immunology 13 (11): 1092-1100. November 2012

The tumour suppressor p53 is frequently nonfunctional in Sezary syndrome.
Lamprecht, B. and Kreher, S. and Moebs, M. and Sterry, W. and Doerken, B. and Janz, M. and Assaf, C. and Mathas, S.
British Journal of Dermatology 167 (2): 240-246. August 2012

Clinical cardiac safety profile of nilotinib.
Kim, T.D. and le Coutre, P. and Schwarz, M. and Grille, P. and Levitin, M. and Fateh-Moghadam, S. and Giles, F.J. and Doerken, B. and Haverkamp, W. and Koehncke, C.
Haematologica 97 (6): 883-889. June 2012

p14ARF-induced apoptosis in p53-deficient cells is mediated by the BH3-only protein independent de-repression of Bak through down-regulation of Mcl-1 and Bcl-xL.
Muer, A. and Overkamp, T. and Gillissen, B. and Richter, A. and Pretzsch, T. and Milojkovic, A. and Doerken, B. and Daniel, P.T. and Hemmati, P.
Journal of Biological Chemistry 287 (21): 17343-17352. 18 May 2012

Reduced-intensity chemotherapy and PET-guided radiotherapy in patients with advanced stage Hodgkin's lymphoma (HD15 trial): a randomised, open-label, phase 3 non-inferiority trial.
Engert, A. and Haverkamp, H. and Kobe, C. and Markova, J. and Renner, C. and Ho, A. and Zijlstra, J. and Kral, Z. and Fuchs, M. and Hallek, M. and Kanz, L. and Doehner, H. and Doerken, B. and Engel, N. and Topp, M. and Klutmann, S. and Amthauer, H. and Bockisch, A. and Kluge, R. and Kratochwil, C. and Schober, O. and Greil, R. and Andreesen, R. and Kneba, M. and Pfreundschuh, M. and Stein, H. and Eich, H.T. and Mueller, R.P. and Dietlein, M. and Borchmann, P. and Diehl, V.
Lancet 379 (9828): 1791-1799. 12 May 2012

Detection of circulating tumor-associated antigen depends on the domains recognized by the monoclonal antibodies used: N-terminal trimmed EpCAM-levels are much higher than untrimmed forms.
Schmetzer, O. and Moldenhauer, G. and Nicolaou, A. and Schlag, P. and Riesenberg, R. and Pezzutto, A.
Immunology Letters 143 (2): 184-192. 30 April 2012

Notch is an essential upstream regulator of NF-κB and is relevant for survival of Hodgkin and Reed-Sternberg cells.
Schwarzer, R. and Doerken, B. and Jundt, F.
Leukemia 26 (4): 806-813. April 2012

NIH-defined graft-versus-host disease after reduced intensity or myeloablative conditioning in patients with acute myeloid leukemia.
Terwey, T.H. and Vega-Ruiz, A. and Hemmati, P.G. and Martus, P. and Dietz, E. and le Coutre, P. and Massenkeil, G. and Doerken, B. and Arnold, R.
Leukemia 26 (3): 536-542. March 2012

New insights into the biology of molecular subtypes of diffuse large B-cell lymphoma and Burkitt lymphoma.
Frick, M. and Doerken, B. and Lenz, G.
Best Practice and Research Clinical Haematology 25 (1): 3-12. March 2012

2011

Eight cycles of escalated-dose BEACOPP compared with four cycles of escalated-dose BEACOPP followed by four cycles of baseline-dose BEACOPP with or without radiotherapy in patients with advanced-stage Hodgkin's lymphoma: final analysis of the HD12 trial of the German Hodgkin study group.
Borchmann, P. and Haverkamp, H. and Diehl, V. and Cerny, T. and Markova, J. and Ho, A.D. and Eich, H.T. and Mueller-Hermelink, H.K. and Kanz, L. and Greil, R. and Rank, A. and Paulus, U. and Smardova, L. and Huber, C. and Doerken, B. and Nerl, C. and Krause, S.W. and Mueller, R.P. and Fuchs, M. and Engert, A.
Journal of Clinical Oncology 29 (32): 4234-4342. 10 November 2011

BAY 43-9006/Sorafenib blocks CSF1R activity and induces apoptosis in various classical Hodgkin lymphoma cell lines.
Ullrich, K. and Wurster, K.D. and Lamprecht, B. and Koechert, K. and Engert, A. and Doerken, B. and Janz, M. and Mathas, S.
British Journal of Haematology 155 (3): 398-402. November 2011

First-line treatment of pancreatic cancer patients with the combination of 5-fluorouracil/folinic acid plus gemcitabine: a multicenter phase II trial by the CONKO-study group.
Pelzer, U. and Arnold, D. and Reitzig, P. and Herrenberger, J. and Korsten, F.W. and Kindler, M. and Stieler, J. and Doerken, B. and Riess, H. and Oettle, H.
Cancer Chemotherapy and Pharmacology 68 (5): 1173-1178. November 2011

Opposing roles of NF-κB in anti-cancer treatment outcome unveiled by cross-species investigations.
Jing, H. and Kase, J. and Doerr, J.R. and Milanovic, M. and Lenze, D. and Grau, M. and Beuster, G. and Ji, S. and Reimann, M. and Lenz, P. and Hummel, M. and Doerken, B. and Lenz, G. and Scheidereit, C. and Schmitt, C.A. and Lee, S.
Genes & Development 25 (20): 2137-2146. 15 October 2011

Severe peripheral arterial disease during nilotinib therapy.
Le Coutre, P. and Rea, D. and Abruzzese, E. and Dombret, H. and Trawinska, M.M. and Herndlhofer, S. and Doerken, B. and Valent, P.
Journal of the National Cancer Institute 103 (17): 1347-1348. 7 September 2011

Antigen-presentation capacity of dendritic cells is impaired in ongoing enterovirus myocarditis.
Rahnefeld, A. and Ebstein, F. and Albrecht, N. and Opitz, E. and Kuckelkorn, U. and Stangl, K. and Rehm, A. and Kloetzel, P.M. and Voigt, A.
European Journal of Immunology 41 (9): 2774-2781. September 2011

Eukaryotic initiation factor 2α phosphorylation is required for B cell maturation and function in mice.
Mielke, N. and Schwarzer, R. and Calkhoven, C.F. and Kaufman, R. and Doerken, B. and Leutz, A. and Jundt, F.
Haematologica 96 (9): 1261-1268. September 2011

Malt1-dependent RelB cleavage promotes canonical NF-κB activation in lymphocytes and lymphoma cell lines.
Hailfinger, S. and Nogai, H. and Pelzer, C. and Jaworski, M. and Cabalzar, K. and Charton, J.E. and Guzzardi, M. and Decaillet, C. and Grau, M. and Doerken, B. and Lenz, P. and Lenz, G. and Thome, M.
Proceedings of the National Academy of Sciences of the United States of America 108 (35): 14596-14601. 30 August 2011

Genomic loss of the putative tumor suppressor gene E2A in human lymphoma.
Steininger, A. and Moebs, M. and Ullmann, R. and Koechert, K. and Kreher, S. and Lamprecht, B. and Anagnostopoulos, I. and Hummel, M. and Richter, J. and Beyer, M. and Janz, M. and Klemke, C.D. and Stein, H. and Doerken, B. and Sterry, W. and Schrock, E. and Mathas, S. and Assaf, C.
Journal of Experimental Medicine 208 (8): 1585-1593. 1 August 2011

Manifestation of spontaneous and early autoimmune gastritis in CCR7-deficient mice.
Winter, S. and Rehm, A. and Wichner, K. and Scheel, T. and Batra, A. and Siegmund, B. and Berek, C. and Lipp, M. and Hoepken, U.E.
American Journal of Pathology 179 (2): 754-765. August 2011

Post-transplantation chronic myeloid leukemia.
le Coutre, P. and Schwarz, M. and Daniel, P. and Doerken, B.
Clinical Advances in Hematology & Oncology 9 (8): 627-629. August 2011

Cooperative function of CCR7 and lymphotoxin in the formation of a lymphoma-permissive niche within murine secondary lymphoid organs.
Rehm, A. and Mensen, A. and Schradi, K. and Gerlach, K. and Wittstock, S. and Winter, S. and Buechner, G. and Doerken, B. and Lipp, M. and Hoepken, U.E.
Blood 118 (4): 1020-1033. 28 July 2011

Serum/glucocorticoid-regulated kinase 1 (SGK1) is a prominent target gene of the transcriptional response to cytokines in multiple myeloma and supports the growth of myeloma cells.
Fagerli, U.M. and Ullrich, K. and Stuehmer, T. and Holien, T. and Koechert, K. and Holt, R.U. and Bruland, O. and Chatterjee, M. and Nogai, H. and Lenz, G. and Shaughnessy, J.D. and Mathas, S. and Sundan, A. and Bargou, R.C. and Doerken, B. and Borset, M. and Janz, M.
Oncogene 30 (28): 3198-3206. 14 July 2011

Best supportive care (BSC) versus oxaliplatin, folinic acid and 5-fluorouracil (OFF) plus BSC in patients for second-line advanced pancreatic cancer: A phase III-study from the German CONKO-study group.
Pelzer, U. and Schwaner, I. and Stieler, J. and Adler, M. and Seraphin, J. and Doerken, B. and Riess, H. and Oettle, H.
European Journal of Cancer 47 (11): 1676-1681. July 2011

The use of microarray technologies in mantle cell lymphoma.
Ratsch, B.A. and Grau, M. and Doerken, B. and Lenz, P. and Lenz, G.
Seminars in Hematology 48 (3): 166-171. July 2011

Pathogenesis of non-Hodgkin's lymphoma.
Nogai, H. and Doerken, B. and Lenz, G.
Journal of Clinical Oncology 29 (14): 1803-1811. 10 May 2011

High-level expression of Mastermind-like 2 contributes to aberrant activation of the NOTCH signaling pathway in human lymphomas.
Koechert, K. and Ullrich, K. and Kreher, S. and Aster, J.C. and Kitagawa, M. and Joehrens, K. and Anagnostopoulos, I. and Jundt, F. and Lamprecht, B. and Zimber-Strobl, U. and Stein, H. and Janz, M. and Doerken, B. and Mathas, S.
Oncogene 30 (15): 1831-1840. 14 April 2011

Protein kinase C inhibitor Sotrastaurin selectively inhibits the growth of CD79-mutant diffuse large B-cell lymphomas.
Naylor, T.L. and Tang, H. and Ratsch, B.A. and Enns, A. and Loo, A. and Chen, L. and Lenz, P. and Schuler, W. and Doerken, B. and Yao, Y.M. and Warmuth, M. and Lenz, G. and Stegmeier, F.
Cancer Research 71 (7): 2643-2653. 1 April 2011

A modified EBMT risk score predicts the outcome of patients with acute myeloid leukemia receiving allogeneic stem cell transplants.
Hemmati, P.G. and Terwey, T.H. and le Coutre, P. and Vuong, L.G. and Massenkeil, G. and Doerken, B. and Arnold, R.
European Journal of Haematology 86 (4): 305-316. April 2011

Notch and NF-κB signaling pathways in the biology of classical Hodgkin lymphoma.
Schwarzer, R. and Jundt, F.
Current Molecular Medicine 11 (3): 236-245. April 2011

Critical role of PI3K signaling for NF-κB-dependent survival in a subset of activated B-cell-like diffuse large B-cell lymphoma cells.
Kloo, B. and Nagel, D. and Pfeifer, M. and Grau, M. and Duewel, M. and Vincendeau, M. and Doerken, B. and Lenz, P. and Lenz, G. and Krappmann, D.
Proceedings of the National Academy of Sciences of the United States of America 108 (1): 272-277. 4 January 2011

Hepatic arterial infusion chemotherapy for liver metastases from gastric cancer: an analysis in western patients.
Floercken, A. and Schaefer, C. and Bichev, D. and Breithaupt, K. and Dogan, Y. and Schumacher, G. and Gebauer, B. and Riess, H. and Doerken, B. and Thuss-Patience, P.C.
Tumori 97 (1): 19-24. January 2011

2010

Reduced-intensity conditioning using fludarabine and antithymocyte globulin alone allows stable engraftment in a patient with Dyskeratosis congenita.
Vuong, L.G. and Hemmati, P.G. and Neuburger, S. and Terwey, T.H. and Vulliamy, T. and Dokal, I. and Le Coutre, P. and Doerken, B. and Arnold, R.
Acta Haematologica 124 (4): 200-203. December 2010

Thyroid dysfunction caused by second-generation tyrosine kinase inhibitors in Philadelphia chromosome-positive chronic myeloid leukemia.
Kim, T.D. and Schwarz, M. and Nogai, H. and Grille, P. and Westermann, J. and Ploeckinger, U. and Braun, D. and Schweizer, U. and Arnold, R. and Doerken, B. and le Coutre, P.
Thyroid 20 (11): 1209-1214. 9 November 2010

Repeat-element driven activation of proto-oncogenes in human malignancies.
Lamprecht, B. and Bonifer, C. and Mathas, S.
Cell Cycle 9 (21): 4276-4281. November 2010

Role of EBAG9 protein in coat protein complex I-dependent glycoprotein maturation and secretion processes in tumor cells.
Wolf, J. and Reimer, T.A. and Schuck, S. and Rueder, C. and Gerlach, K. and Mueller, E.C. and Otto, A. and Doerken, B. and Rehm, A.
FASEB Journal 24 (10): 4000-4019. October 2010

Intensified chemotherapy and dose-reduced involved-field radiotherapy in patients with early unfavorable Hodgkin's lymphoma: final analysis of the German Hodgkin Study Group HD11 trial.
Eich, H.T. and Diehl, V. and Goergens, H. and Pabst, T. and Markova, J. and Debus, J. and Ho, A. and Doerken, B. and Rank, A. and Grosu, A.L. and Wiegel, T. and Karstens, J.H. and Greil, R. and Willich, N. and Schmidberger, H. and Doehner, H. and Borchmann, P. and Mueller-Hermelink, H.K. and Mueller, R.P. and Engert, A.
Journal of Clinical Oncology 28 (27): 4199-4206. 20 September 2010

Common clonal origin of an acute B lymphoblastic leukemia and a Langerhans' cell sarcoma: evidence for hematopoietic plasticity.
Ratei, R. and Hummel, M. and Anagnostopoulos, I. and Jaehne, D. and Arnold, R. and Doerken, B. and Mathas, S. and Thomas, B. and Dudeck, O. and Ludwig, W.D. and Stein, H.
Haematologica 95 (9): 1461-1466. September 2010

Reduced treatment intensity in patients with early-stage Hodgkin's lymphoma.
Engert, A. and Pluetschow, A. and Eich, H.T. and Lohri, A. and Doerken, B. and Borchmann, P. and Berger, B. and Greil, R. and Willborn, K.C. and Wilhelm, M. and Debus, J. and Eble, M.J. and Soekler, M. and Ho, A. and Rank, A. and Ganser, A. and Truemper, L. and Bokemeyer, C. and Kirchner, H. and Schubert, J. and Kral, Z. and Fuchs, M. and Mueller-Hermelink, H.K. and Mueller, R.P. and Diehl, V.
New England Journal of Medicine 363 (7): 640-652. 12 August 2010

Cellular senescence predicts treatment outcome in metastasised colorectal cancer.
Haugstetter, A.M. and Loddenkemper, C. and Lenze, D. and Groene, J. and Standfuss, C. and Petersen, I. and Doerken, B. and Schmitt, C.A.
British Journal of Cancer 103 (4): 505-509. 10 August 2010

Fatal immune haemolysis due to antibodies to individual metabolites of 5-fluorouracil.
Yuerek, S. and Riess, H. and Kreher, S. and Doerken, B. and Salama, A.
Transfusion Medicine 20 (4): 265-268. 1 August 2010

A modified EBMT risk score and the hematopoietic cell transplantation-specific comorbidity index for pre-transplant risk assessment in adult acute lymphoblastic leukemia.
Terwey, T.H. and Hemmati, P.G. and Martus, P. and Dietz, E. and Vuong, L.G. and Massenkeil, G. and Doerken, B. and Arnold, R.
Haematologica 95 (5): 810-818. May 2010

Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma.
Lamprecht, B. and Walter, K. and Kreher, S. and Kumar, R. and Hummel, M. and Lenze, D. and Koechert, K. and Bouhlel, M.A. and Richter, J. and Soler, E. and Stadhouders, R. and Joehrens, K. and Wurster, K.D. and Callen, D.F. and Harte, M.F. and Giefing, M. and Barlow, R. and Stein, H. and Anagnostopoulos, I. and Janz, M. and Cockerill, P.N. and Siebert, R. and Doerken, B. and Bonifer, C. and Mathas, S.
Nature Medicine 16 (5): 571-579, 1p following 579. May 2010

Reduced intensity conditioning prior to allogeneic stem cell transplantation in first complete remission is effective in patients with acute myeloid leukemia and an intermediate-risk karyotype.
Hemmati, P.G. and Terwey, T.H. and Massenkeil, G. and le Coutre, P. and Vuong, L.G. and Neuburger, S. and Doerken, B. and Arnold, R.
International Journal of Hematology 91 (3): 436-445. April 2010

Tumor stroma-derived TGF-beta limits Myc-driven lymphomagenesis via Suv39h1-dependent senescence.
Reimann, M. and Lee, S. and Loddenkemper, C. and Doerr, J.R. and Tabor, V. and Aichele, P. and Stein, H. and Doerken, B. and Jenuwein, T. and Schmitt, C.A.
Cancer Cell 17 (3): 262-272. 16 March 2010

Parenteral nutrition support for patients with pancreatic cancer. Results of a phase II study.
Pelzer, U. and Arnold, D. and Govercin, M. and Stieler, J. and Doerken, B. and Riess, H. and Oettle, H.
BMC Cancer 10 (1): 86. 9 March 2010

C/EBPbetaDeltauORF mice--a genetic model for uORF-mediated translational control in mammals.
Wethmar, K. and Begay, V. and Smink, J.J. and Zaragoza, K. and Wiesenthal, V. and Doerken, B. and Calkhoven, C.F. and Leutz, A.
Genes & Development 24 (1): 15-20. 1 January 2010

2009

The dangers of transcription.
Mathas, S. and Misteli, T.
Cell 139 (6): 1047-1049. 11 December 2009

Identification of a chemokine receptor profile characteristic for mediastinal large B-cell lymphoma.
Rehm, A. and Anagnostopoulos, I. and Gerlach, K. and Broemer, M. and Scheidereit, C. and Joehrens, K. and Huebler, M. and Hetzer, R. and Stein, H. and Lipp, M. and Doerken, B. and Hoepken, U.E.
International Journal of Cancer 125 (10): 2367-2374. 15 November 2009

Severe thrombocytopenia in a patient with metastatic renal cell carcinoma.
Floercken, A. and Loew, A. and Koch, M. and Gebauer, B. and Doerken, B. and Riess, H.
Onkologie 32 (11): 670-672. November 2009

C/EBPβ regulates transcription factors critical for proliferation and survival of multiple myeloma cells.
Pal, R. and Janz, M. and Galson, D.L. and Gries, M. and Li, S. and Johrens, K. and Anagnostopoulos, I. and Doerken, B. and Mapara, M.Y. and Borghesi, L. and Kardava, L. and Roodman, G.D. and Milcarek, C. and Lentzsch, S.
Blood 114 (18): 3890-3898. 29 October 2009

Treatment of PTLD with rituximab and CHOP reduces the risk of renal graft impairment after reduction of immunosuppression.
Trappe, R. and Hinrichs, C. and Appel, U. and Babel, N. and Reinke, P. and Neumayer, H.H. and Budde, K. and Dreyling, M. and Duehrsen, U. and Kliem, V. and Schuettrumpf, S. and Hauser, I.A. and Mergenthaler, H.G. and Schlattmann, P. and Anagnostopoulos, I. and Doerken, B. and Riess, H.
American Journal of Transplantation 9 (10): 2331-2337. October 2009

Escalated-dose BEACOPP in the treatment of patients with advanced-stage Hodgkin's lymphoma: 10 years of follow-up of the GHSG HD9 study.
Engert, A. and Diehl, V. and Franklin, J. and Lohri, A. and Doerken, B. and Ludwig, W.D. and Koch, P. and Haenel, M. and Pfreundschuh, M. and Wilhelm, M. and Truemper, L. and Aulitzky, W.E. and Bentz, M. and Rummel, M. and Sezer, O. and Mueller-Hermelink, H.K. and Hasenclever, D. and Loeffler, M.
Journal of Clinical Oncology 27 (27): 4548-4554. 20 September 2009

Die molekulare Pathogenese des klassischen Hodgkin-Lymphoms [The molecular pathogenesis of classical Hodgkin lymphoma].
Mathas, S. and Doerken, B. and Janz, M.
Deutsche Medizinische Wochenschrift 134 (39): 1944-1948. September 2009

The tumor-associated antigen EBAG9 negatively regulates the cytolytic capacity of mouse CD8+ T cells.
Rueder, C. and Hoepken, U.E. and Wolf, J. and Mittruecker, H.W. and Engels, B. and Erdmann, B. and Wollenzin, S. and Uckert, W. and Doerken, B. and Rehm, A.
Journal of Clinical Investigation 119 (8): 2184-2203. August 2009

Reactivation of hepatitis E infection in a patient with acute lymphoblastic leukaemia after allogeneic stem cell transplantation.
le Coutre, P. and Meisel, H. and Hofmann, J. and Roecken, C. and Vuong, G.L. and Neuburger, S. and Hemmati, P.G. and Doerken, B. and Arnold, R.
Gut 58 (5): 699-702. May 2009

Gene deregulation and spatial genome reorganization near breakpoints prior to formation of translocations in anaplastic large cell lymphoma.
Mathas, S. and Kreher, S. and Meaburn, K.J. and Joehrens, K. and Lamprecht, B. and Assaf, C. and Sterry, W. and Kadin, M.E. and Daibata, M. and Joos, S. and Hummel, M. and Stein, H. and Janz, M. and Anagnostopoulos, I. and Schrock, E. and Misteli, T. and Doerken, B.
Proceedings of the National Academy of Sciences of the United States of America 106 (14): 5831-5836. 7 April 2009

Second-line therapy in refractory pancreatic cancer. results of a phase II study.
Pelzer, U. and Stieler, J. and Roll, L. and Hilbig, A. and Doerken, B. and Riess, H. and Oettle, H.
Onkologie 32 (3): 99-102. March 2009

Use of Kaede fusions to visualize recycling of G protein-coupled receptors.
Schmidt, A. and Wiesner, B. and Weisshart, K. and Schulz, K. and Furkert, J. and Lamprecht, B. and Rosenthal, W. and Schuelein, R.
Traffic 10 (1): 2-15. January 2009

2008

Rationale and design of PROSPECT-CONKO 004: a prospective, randomized trial of simultaneous pancreatic cancer treatment with enoxaparin and chemotherapy.
Riess, H. and Pelzer, U. and Hilbig, A. and Stieler, J. and Opitz, B. and Scholten, T. and Kauschat-Bruning, D. and Bramlage, P. and Doerken, B. and Oettle, H.
BMC Cancer 8 (1): 361. 5 December 2008

Allogeneic SCT in refractory or relapsed adult ALL is effective without prior reinduction chemotherapy.
Terwey, T.H. and Massenkeil, G. and Tamm, I. and Hemmati, P.G. and Neuburger, S. and Martus, P. and Doerken, B. and Hoelzer, D. and Arnold, R.
Bone Marrow Transplantation 42 (12): 791-798. December 2008

Notch inhibition blocks multiple myeloma cell-induced osteoclast activation.
Schwarzer, R. and Kaiser, M. and Acikgoez, O. and Heider, U. and Mathas, S. and Preissner, R. and Sezer, O. and Doerken, B. and Jundt, F.
Leukemia 22 (12): 2273-2277. December 2008

Aberrant expression of the Th2 cytokine IL-21 in Hodgkin lymphoma cells regulates STAT3 signaling and attracts Treg cells via regulation of MIP-3α.
Lamprecht, B. and Kreher, S. and Anagnostopoulos, I. and Joehrens, K. and Monteleone, G. and Jundt, F. and Stein, H. and Janz, M. and Doerken, B. and Mathas, S.
Blood 112 (8): 3339-3347. 15 October 2008

The pathogenesis of classical Hodgkin's lymphoma: what can we learn from analyses of genomic alterations in Hodgkin and Reed-Sternberg cells?
Janz, M. and Mathas, S.
Haematologica 93 (9): 1292-1295. September 2008

Aberrant expression of Notch1 interferes with the B-lymphoid phenotype of neoplastic B cells in classical Hodgkin lymphoma.
Jundt, F. and Acikgoez, O. and Kwon, S.H. and Schwarzer, R. and Anagnostopoulos, I. and Wiesner, B. and Mathas, S. and Hummel, M. and Stein, H. and Reichardt, H.M. and Doerken, B.
Leukemia 22 (8): 1587-1594. August 2008

IkappaBalpha is required for marginal zone B cell lineage development.
Ellinghaus, U. and Rupec, R.A. and Pabst, O. and Ignatius, R. and Foerster, R. and Doerken, B. and Jundt, F.
European Journal of Immunology 38 (8): 2096-2105. August 2008

Successful salvage treatment of disseminated cutaneous fusariosis with liposomal amphotericin B and terbinafine after allogeneic stem cell transplantation.
Neuburger, S. and Massenkeil, G. and Seibold, M. and Lutz, C. and TammI, I. and Le Coutre, P. and Graf, B. and Doerken, B. and Arnold, R.
Transplant Infectious Disease 10 (4): 290-293. August 2008

Epigenetic and genetic analysis of the survivin promoter in acute myeloid leukemia.
Wagner, M. and Schmelz, K. and Doerken, B. and Tamm, I.
Leukemia Research 32 (7): 1054-1060. July 2008

A pilot study of prophylactic donor lymphocyte infusions to prevent relapse in adult acute lymphoblastic leukemias after allogeneic hematopoietic stem cell transplantation.
Lutz, C. and Massenkeil, G. and Nagy, M. and Neuburger, S. and Tamm, I. and Rosen, O. and Doerken, B. and Arnold, R.
Bone Marrow Transplantation 41 (9): 805-812. May 2008

Transcriptional regulation of human survivin by early growth response (Egr)-1 transcription factor.
Wagner, M. and Schmelz, K. and Doerken, B. and Tamm, I.
International Journal of Cancer 122 (6): 1278-1287. 15 March 2008

Notch signaling in leukemias and lymphomas.
Jundt, F. and Schwarzer, R. and Doerken, B.
Current Molecular Medicine 8 (1): 51-59. February 2008

2007

Salvage therapy for relapsed posttransplant lymphoproliferative disorders (PTLD) with a second progression of PTLD after upfront chemotherapy: the role of single-agent rituximab.
Trappe, R.U. and Choquet, S. and Reinke, P. and Dreyling, M. and Mergenthaler, H.G. and Jaeger, U. and Kebelmann-Betzing, C. and Jonas, S. and Lehmkuhl, H. and Anagnostopoulos, I. and Leblond, V. and Hetzer, R. and Doerken, B. and Riess, H. and Oertel, S.
Transplantation 84 (12): 1708-1712. 27 December 2007

The Myc-evoked DNA damage response accounts for treatment resistance in primary lymphomas in vivo.
Reimann, M. and Loddenkemper, C. and Rudolph, C. and Schildhauer, I. and Teichmann, B. and Stein, H. and Schlegelberger, B. and Doerken, B. and Schmitt, C.A.
Blood 110 (8): 2996-3004. 15 October 2007

The UT-A1 urea transporter interacts with snapin, a SNARE-associated protein.
Mistry, A.C. and Mallick, R. and Froehlich, O. and Klein, J.D. and Rehm, A. and Chen, G. and Sands, J.M.
Journal of Biological Chemistry 282 (41): 30097-30106. 12 October 2007

In vivo splenic CD11c cells downregulate CD4 T-cell response thereby decreasing systemic immunity to gene-modified tumour cell vaccine.
Cayeux, S. and Bukarica, B. and Buschow, C. and Charo, J. and Bunse, M. and Doerken, B. and Blankenstein, T.
Gene Therapy 14 (20): 1481-1491. October 2007

The pathogenesis of classical Hodgkin's lymphoma: a model for B-cell plasticity.
Mathas, S.
Hematology Oncology Clinics of North America 21 (5): 787-804. October 2007

Rituximab in the management of post-transplantation lymphoproliferative disorder after solid organ transplantation: proceed with caution.
Choquet, S. and Oertel, S. and Leblond, V. and Riess, H. and Varoqueaux, N. and Doerken, B. and Trappe, R.
Annals of Hematology 86 (8): 599-607. August 2007

Intraoperative fresh-frozen plasma versus human albumin in craniofacial surgery - a pilot study comparing coagulation profiles in infants younger than 12 months.
Hildebrandt, B. and Machotta, A. and Riess, H. and Kerner, S. and Ahlers, O. and Haberl, H. and Doerken, B. and Kerner, T.
Thrombosis and Haemostasis 98 (1): 172-7. July 2007

Loss of bHLH transcription factor E2A activity in primary effusion lymphoma confers resistance to apoptosis.
Lietz, A. and Janz, M. and Sigvardsson, M. and Jundt, F. and Doerken, B. and Mathas, S.
British Journal of Haematology 137 (4): 342-348. May 2007

Interventionally implanted port catheter systems for hepatic arterial infusion of chemotherapy in patients with colorectal liver metastases: A phase II-study and historical comparison with the surgical approach.
Hildebrandt, B. and Pech, M. and Nicolaou, A. and Langrehr, J.M. and Kurcz, J. and Bartels, B. and Miersch, A. and Felix, R. and Neuhaus, P. and Riess, H. and Doerken, B. and Ricke, J.
BMC Cancer 7 : 69. 24 April 2007

Salvage chemotherapy for refractory and relapsed posttransplant lymphoproliferative disorders (PTLD) after treatment with single-agent rituximab.
Trappe, R. and Riess, H. and Babel, N. and Hummel, M. and Lehmkuhl, H. and Jonas, S. and Anagnostopoulos, I. and Papp-Vary, M. and Reinke, P. and Hetzer, R. and Doerken, B. and Oertel, S.
Transplantation 83 (7): 912-918. 15 April 2007

Pharmacologic activation of p53-dependent and p53-independent apoptotic pathways in Hodgkin/Reed-Sternberg cells.
Janz, M. and Stuehmer, T. and Vassilev, L.T. and Bargou, R.C.
Leukemia 21 (4): 772-779. April 2007

Dendritic cell maturation stage determines susceptibility to the proteasome inhibitor bortezomib.
Subklewe, M. and Sebelin-Wulf, K. and Beier, C. and Lietz, A. and Mathas, S. and Doerken, B. and Pezzutto, A.
Human Immunology 68 (3): 147-155. March 2007

CCR7 deficiency causes ectopic lymphoid neogenesis and disturbed mucosal tissue integrity.
Hoepken, U.E. and Wengner, A.M. and Loddenkemper, C. and Stein, H. and Heimesaat, M.M. and Rehm, A. and Lipp, M.
Blood 109 (3): 886-895. 1 February 2007

Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: a randomized controlled trial.
Oettle, H. and Post, S. and Neuhaus, P. and Gellert, K. and Langrehr, J. and Ridwelski, K. and Schramm, H. and Fahlke, J. and Zuelke, C. and Burkart, C. and Gutberlet, K. and Kettner, E. and Schmalenberg, H. and Weigang-Koehler, K. and Bechstein, W.O. and Niedergethmann, M. and Schmidt-Wolf, I. and Roll, L. and Doerken, B. and Riess, H.
JAMA: Journal of the American Medical Association 297 (3): 267-277. 17 January 2007

STAT3 and MAPK signaling maintains overexpression of the heat shock proteins 90a and b in multiple myeloma cells, which critically contribute to tumor cell survival.
Chatterjee, M. and Jain, S. and Stuehmer, T. and Andrulis, M. and Ungethuem, U. and Kuban, R.J. and Lorentz, H. and Bommert, K. and Topp, M. and Kramer, D. and Mueller-Hermelink, H. K. and Einsele, H. and Greiner, A. and Bargou, R.C.
Blood 109 (2): 720-728. 15 January 2007

Initial chemotherapy with mitoxantrone, chlorambucil, prednisone impairs the collection of stem cells in patients with indolent lymphomas--results of a randomized comparison by the German Low-Grade Lymphoma Study Group.
Nickenig, C. and Dreyling, M. and Hoster, E. and Ludwig, W.D. and Doerken, B. and Freund, M. and Huber, C. and Ganser, A. and Truemper, L. and Forstpointner, R. and Unterhalt, M. and Hiddemann, W.
Annals of Oncology 18 (1): 136-142. January 2007

2006

Author reply: Polyclonal resistance in gastrointestinal stromal tumor treated with sequential kinase inhibitors.
Wardelmann, E. and Biermann, K. and Merkelbach-Bruse, S. and Thomas, N. and Schildhaus, H.U. and Heinicke, T. and Speidel, N. and Pietsch, T. and Buettner, R. and Pink, D. and Reichardt, P. and Hohenberger, P.
Clinical Cancer Research 12 (20): 6206-6207. 15 October 2006

In vivo expression of survivin and its splice variant survivin-2B: Impact on clinical outcome in acute myeloid leukemia.
Wagner, M. and Schmelz, K. and Wuchter, C. and Ludwig, W.D. and Doerken, B. and Tamm, I.
International Journal of Cancer 119 : 1291-1297. 15 September 2006

Adjuvant chemotherapy with folinic acid and 5-fluorouracil in patients with locally advanced rectal cancer previously treated by preoperative radiochemotherapy and curative tumor resection.
Hildebrandt, B. and Rau, B. and Loeffel, J. and Wust, P. and Nicolaou, A. and Gellermann, J. and Le Coutre, P. and Neuhaus, P. and Felix, R. and Wernecke, K.D. and Doerken, B. and Riess, H.
International Journal of Colorectal Disease 21 (6): 582-589. September 2006

Long-lasting remission of pulmonary metastases of renal cell cancer under IFN-beta therapy in a patient with multiple sclerosis.
Floercken, A. and Denecke, T. and Kretzschmar, A. and Gollasch, H. and Reich, G. and Westermann, J.
Onkologie 29 : 382-384. September 2006

Untersuchungen zur Molekularpathologie des Hodgkin-Lymphoms - Klonierung des I kappa B epsilon Gens und Mutationsanalyse in Einzelzellen.
Theurich, S.
UNSPECIFIED thesis, UNSPECIFIED. 24 July 2006

Chromosomal rearrangements involving the BCL3 locus are recurrent in classical Hodgkin and peripheral T-cell lymphoma.
Martin-Subero, J.I. and Wlodarska, I. and Bastard, C. and Picquenot, J.M. and Hoeppner, J. and Giefing, M. and Klapper, W. and Siebert, R. and Mathas, S. and Joos, S. and Stein, H. and Doerken, B.
Blood 108 : 401-403. 1 July 2006

Epstein-Barr viral load in whole blood of adults with posttransplant lymphoproliferative disorder after solid organ transplantation does not correlate with clinical course.
Oertel, S. and Trappe, R.U. and Zeidler, K. and Babel, N. and Reinke, P. and Hummel, M. and Jonas, S. and Papp-Vary, M. and Subklewe, M. and Doerken, B. and Riess, H. and Gaertner, B.
Annals of Hematology 85 : 478-484. July 2006

Harm or benefit of hormonal treatment in metastatic low-grade endometrial stromal sarcoma: Single center experience with 10 cases and review of the literature.
Pink, D. and Lindner, T. and Mrozek, A. and Kretzschmar, A. and Thuss-Patience, P.C. and Doerken, B. and Reichardt, P.
Gynecologic Oncology 101 : 464-469. June 2006

Reprogramming of B lymphoid cells in human lymphoma pathogenesis.
Janz, M. and Doerken, B. and Mathas, S.
Cell Cycle 5 (10): 1057-1061. 15 May 2006

T-cell activation and B-cell depletion in chimpanzees treated with a bispecific anti-CD19/anti-CD3 single-chain antibody construct.
Schlereth, B. and Quadt, C. and Dreier, T. and Kufer, P. and Lorenczewski, G. and Prang, N. and Brandl, C. and Lippold, S. and Cobb, K. and Brasky, K. and Leo, E. and Bargou, R. and Murthy, K. and Baeuerle, P.A.
Cancer Immunology Immunotherapy 55 : 503-514. May 2006

Loss of the tissue-specific proapoptotic BH3-only protein Nbk/Bik is a unifying feature of renal cell carcinoma.
Sturm, I. and Stephan, C. and Gillissen, B. and Siebert, R. and Janz, M. and Radetzki, S. and Jung, K. and Loening, S. and Doerken, B. and Daniel, P.T.
Cell Death and Differentiation 13 : 619-627. April 2006

Classical Hodgkin lymphoma is characterized by high constitutive expression of activating transcription factor 3 (ATF3) which promotes viability of Hodgkin/Reed-Sternberg cells.
Janz, M. and Hummel, M. and Truss, M. and Wollert-Wulf, B. and Mathas, S. and Joehrens, K. and Hagemeier, C. and Bommert, K. and Stein, H. and Doerken, B. and Bargou, R.C.
Blood 107 (6): 2536-2539. 15 March 2006

Polyclonal evolution of multiple secondary KIT mutations in gastrointestinal stromal tumors under treatment with imatinib mesylate.
Wardelmann, E. and Merkelbach-Bruse, S. and Pauls, K. and Thomas, N. and Schildhaus, H.U. and Heinicke, T. and Speidel, N. and Pietsch, T. and Buettner, R. and Pink, D. and Reichardt, P. and Hohenberger, P.
Clinical Cancer Research 12 : 1743-1749. 15 March 2006

Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma.
Mathas, S. and Janz, M. and Hummel, F. and Hummel, M. and Wollert-Wulf, B. and Lusatis, S. and Anagnostopoulos, I. and Lietz, A. and Sigvardsson, M. and Jundt, F. and Joehrens, K. and Bommert, K. and Stein, H. and Doerken, B.
Nature Immunology 7 (2): 207-215. February 2006

Successful treatment of thrombocytopenia in primary antiphospholipid antibody syndrome with the anti-CD20 antibody rituximab-monitoring of antiphospholipid and anti-GP antibodies: a case report.
Trappe, R. and Loew, A. and Thuss-Patience, P. and Doerken, B. and Riess, H.
Annals of Hematology 85 : 134-135. February 2006

Four versus six courses of a dose-escalated cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) regimen plus etoposide (megaCHOEP) and autologous stem cell transplantation.
Schmitz, N. and Kloess, M. and Reiser, M. and Berdel, W.E. and Metzner, B. and Doerken, B. and Kneba, M. and Trumper, L. and Loeffler, M. and Pfreundschuh, M. and Glass, B.
Cancer 106 : 136-145. 1 January 2006

Selective pharmacologic activation of the p53-dependent pathway as a therapeutic strategy for hematologic malignancies.
Stuehmer, T. and Bargou, R.C.
Cell Cycle 5 : 39-42. 1 January 2006

Leukemia.
Bargou, R. and Ludwig, W.D.
In: Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine ; Vol. 1. Springer, Berlin [u.a.], 967-974. ISBN 3-540-44244-8 2006

2005

Effect of anti-CD 20 antibody rituximab in patients with post-transplant lymphoproliferative disorder (PTLD).
Oertel, S.H. and Verschuuren, E. and Reinke, P. and Zeidler, K. and Papp-Vary, M. and Babel, N. and Trappe, R.U. and Jonas, S. and Hummel, M. and Anagnostopoulos, I. and Doerken, B. and Riess, H.B.
American Journal of Transplantation 5 : 2901-2906. 1 December 2005

CD52 is not a promising immunotherapy target for most patients with multiple myeloma.
Westermann, J. and Maschmeyer, G. and Lessen, A. and Doerken, B. and Pezzutto, A.
International Journal of Hematology 82 : 248-250. 1 October 2005

The ratio between dendritic cells and T cells determines the outcome of their encounter: Proliferation versus deletion.
Hoepken, U.E. and Lehmann, I. and Droese, J. and Lipp, M. and Schueler, T. and Rehm, A.
European Journal of Immunology 35 (10): 2851-2863. 23 September 2005

Elevated NF-kappaB p50 complex formation and Bcl-3 expression in classical Hodgkin, anaplastic large cell, and other peripheral T-cell lymphomas.
Mathas, S. and Joehrens, K. and Joos, S. and Lietz, A. and Hummel, F. and Janz, M. and Jundt, F. and Anagnostopoulos, I. and Bommert, K. and Lichter, P. and Stein, H. and Scheidereit, C. and Doerken, B.
Blood 106 (13): 4287-4293. 25 August 2005

Survival after reduced-intensity conditioning is not inferior to standard high-dose conditioning before allogeneic haematopoietic cell transplantation in acute leukaemias.
Massenkeil, G. and Nagy, M. and Neuburger, S. and Tamm, I. and Lutz, C. and Le Coutre, P. and Rosen, O. and Wernecke, K.D. and Doerken, B. and Arnold, R.
Bone Marrow Transplantation 36 : 683-689. 22 August 2005

In B-CLL, the codon 72 polymorphic variants of p53 are not related to drug resistance and disease prognosis.
Sturm, I. and Bosanquet, A.G. and Hummel, M. and Doerken, B. and Daniel, P.T.
BMC Cancer 5 : 105. 18 August 2005

Non-genotoxic activation of the p53 pathway as a therapeutic strategy for multiple myeloma.
Stuehmer, T. and Chatterjee, M. and Hildebrandt, M. and Herrmann, P. and Gollasch, H. and Gerecke, C. and Theurich, S. and Cigliano, L. and Manz, R.A. and Daniel, P.T. and Bommert, K. and Vassilev, L.T. and Bargou, R.C.
Blood 106 : 3609-3617. 4 August 2005

Oncogene-induced senescence as an initial barrier in lymphoma development.
Braig, M. and Lee, S. and Loddenkemper, C. and Rudolph, C. and Peters, A.H. and Schlegelberger, B. and Stein, H. and Doerken, B. and Jenuwein, T. and Schmitt, C.A.
Nature 436 (7051): 660-665. 4 August 2005

Prognostic value of multimarker analysis in stage III colorectal cancer: one step forward towards an individualized therapy decision.
Grabowski, P. and Maaser, K. and Hanski, C. and Stein, H. and Sturm, I. and Hopfenmueller, W. and Doerken, B. and Buhr, H.J. and Zeitz, M. and Scheruebl, H.
Onkologie 28 (8-9): 399-403. 1 August 2005

Grundlagen der molekularen Diagnostik und Therapie maligner Tumoren [Basics of molecular diagnostics and therapy of malignant tumors].
Daniel, P.T. and Doerken, B.
Internist 46 (8): 835-846. 12 July 2005

Empirical antimicrobial monotherapy in patients after high-dose chemotherapy and autologous stem cell transplantation: a randomised, multicentre trial.
Reich, G. and Cornely, O.A. and Sandherr, M. and Kubin, T. and Krause, S. and Einsele, H. and Thiel, E. and Bellaire, T. and Doerken, B. and Maschmeyer, G.
British Journal of Haematology 130 : 265-270. 1 July 2005

YB-1 provokes breast cancer through the induction of chromosomal instability that emerges from mitotic failure and centrosome amplification.
Bergmann, S. and Royer-Pokora, B. and Fietze, E. and Juerchott, K. and Hildebrandt, B. and Trost, D. and Leenders, F. and Claude, J.C. and Theuring, F. and Bargou, R. and Dietel, M. and Royer, H.D.
Cancer Research 65 (10): 4078-4087. 16 May 2005

5-Aza-2'-deoxycytidine induces p21WAF expression by demethylation of p73 leading to p53-independent apoptosis in myeloid leukemia.
Schmelz, K. and Wagner, M. and Doerken, B. and Tamm, I.
International Journal of Cancer 114 : 683-695. 1 May 2005

Imatinib mesylate radiosensitizes human glioblastoma cells through inhibition of platelet-derived growth factor receptor.
Holdhoff, M. and Kreuzer, K.A. and Appelt, C. and Scholz, R. and Na, I.K. and Hildebrandt, B. and Riess, H. and Jordan, A. and Schmidt, C.A. and Van Etten, R.A. and Doerken, B. and LeCoutre, P.
Blood Cells Molecules and Diseases 34 (2): 181-185. 1 March 2005

EBAG9 adds a new layer of control on large dense-core vesicle exocytosis via interaction with Snapin.
Rueder, C. and Reimer, T. and Delgado-Martinez, I. and Hermosilla, R. and Engelsberg, A. and Nehring, R. and Doerken, B. and Rehm, A.
Molecular Biology of the Cell 16 (3): 1245-1257. 5 January 2005

A rapamycin derivative (everolimus) controls proliferation through down-regulation of truncated CCAAT enhancer binding protein beta and NF-kappaB activity in Hodgkin and anaplastic large cell lymphomas.
Jundt, F. and Raetzel, N. and Mueller, C. and Calkhoven, C.F. and Kley, K. and Mathas, S. and Lietz, A. and Leutz, A. and Doerken, B.
Blood 106 : 1801-1807. 1 January 2005

Cologne high-dose sequential chemotherapy in relapsed and refractory Hodgkin lymphoma: results of a large multicenter study of the German Hodgkin Lymphoma Study Group (GHSG).
Josting, A. and Rudolph, C. and Mapara, M. and Glossmann, J.P. and Sieniawski, M. and Sieber, M. and Kirchner, H.H. and Doerken, B. and Hossfeld, D.K. and Kisro, J. and Metzner, B. and Berdel, W.E. and Diehl, V. and Engert, A.
Annals of Oncology 16 : 116-123. 1 January 2005

Distinction of acute lymphoblastic leukemia from acute myeloid leukemia through microarray-based DNA methylation analysis.
Scholz, C. and Nimmrich, I. and Burger, M. and Becker, E. and Doerken, B. and Ludwig, W.D. and Maier, S.
Annals of Hematology 84 : 236-244. 1 January 2005

Docetaxel and continuous-infusion fluorouracil versus epirubicin, cisplatin, and fluorouracil for advanced gastric adenocarcinoma: a randomized phase II study.
Thuss-Patience, P.C. and Kretzschmar, A. and Repp, M. and Kingreen, D. and Hennesser, D. and Micheel, S. and Pink, D. and Scholz, C. and Doerken, B. and Reichardt, P.
Journal of Clinical Oncology 23 : 494-501. 1 January 2005

Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin.
Ding, Q. and Xia, W. and Liu, J.C. and Yang, J.Y. and Lee, D.F. and Xia, J. and Bartholomeusz, G. and Li, Y. and Pan, Y. and Li, Z. and Bargou, R.C. and Qin, J. and Lai, C.C. and Tsai, F.J. and Tsai, C.H. and Hung, M.C.
Molecular Cell 19 : 159-170. 1 January 2005

High-dose sequential chemotherapy followed by autologous stem cell transplantation in relapsed and refractory aggressive non-Hodgkin's lymphoma: results of a multicenter phase II study.
Josting, A. and Sieniawski, M. and Glossmann, J.P. and Staak, O. and Nogova, L. and Peters, N. and Mapara, M. and Doerken, B. and Ko, Y. and Metzner, B. and Kisro, J. and Diehl, V. and Engert, A.
Annals of Oncology 16 : 1359-1365. 1 January 2005

Immunomodulatory derivative of thalidomide (IMiD CC-4047) induces a shift in lineage commitment by suppressing erythropoiesis and promoting myelopoiesis.
Koh, K.R. and Janz, M. and Mapara, M.Y. and Lemke, B. and Stirling, D. and Doerken, B. and Zenke, M. and Lentzsch, S.
Blood 105 (10): 3833-3840. 1 January 2005

Induction of gene expression by 5-Aza-2'-deoxycytidine in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) but not epithelial cells by DNA-methylation-dependent and -independent mechanisms.
Schmelz, K. and Sattler, N. and Wagner, M. and Luebbert, M. and Doerken, B. and Tamm, I.
Leukemia 19 : 103-111. 1 January 2005

Reevaluation of the 22-1-1 antibody and its putative antigen, EBAG9/RCAS1, as a tumor marker.
Reimer, T.A. and Anagnostopoulos, I. and Erdmann, B. and Lehmann, I. and Stein, H. and Daniel, P. and Doerken, B. and Rehm, A.
BMC Cancer 5 (1): 47. 1 January 2005

Serial killing of tumor cells by cytotoxic T cells redirected with a CD19-/CD3-bispecific single-chain antibody construct.
Hoffmann, P. and Hofmeister, R. and Brischwein, K. and Brandl, C. and Crommer, S. and Bargou, R. and Itin, C. and Prang, N. and Baeuerle, P.A.
International Journal of Cancer 115 : 98-104. 1 January 2005

Stroma-mediated dysregulation of myelopoiesis in mice lacking IkappaBalpha.
Rupec, R.A. and Jundt, F. and Rebholz, B. and Eckelt, B. and Weindl, G.N. and Herzinger, T. and Flaig, M.J. and Moosmann, S. and Plewig, G. and Doerken, B. and Foerster, I. and Huss, R. and Pfeffer, K.
Immunity 22 : 479-491. 1 January 2005

2004

HCMV-encoded chemokine receptor US28 employs multiple routes for internalization.
Droese, J. and Mokros, T. and Hermosilla, R. and Schuelein, R. and Lipp, M. and Hoepken, U.E. and Rehm, A.
Biochemical and Biophysical Research Communications 322 (1): 42-49. 10 September 2004

Nonmyeloablative stem cell transplantation in metastatic renal cell carcinoma: delayed graft-versus-tumor effect is associated with chimerism conversion but transplantation has high toxicity.
Massenkeil, G. and Roigas, J. and Nagy, M. and Wille, A. and Stroszczynski, C. and Mapara, M.Y. and Loening, S. and Doerken, B. and Arnold, R.
Bone Marrow Transplantation 34 (4): 309-316. 1 August 2004

Characterization of apoptosis-induced Mcm3 and Cdc6 cleavage reveals a proapoptotic effect for one Mcm3 fragment.
Schories, B. and Engel, K. and Doerken, B. and Gossen, M. and Bommert, K.
Cell Death and Differentiation 11 (8): 940-942. August 2004

Trimethoprim-sulfamethoxazole exacerbates posthypoxic action myoclonus in a patient with suspicion of Pneumocystis jiroveci infection.
Jundt, F. and Lempert, T. and Doerken, B. and Pezzutto, A.
Infection 32 (3): 176-178. 1 June 2004

c-FLIP mediates resistance of Hodgkin/Reed-Sternberg cells to death receptor-induced apoptosis.
Mathas, S. and Lietz, A. and Anagnostopoulos, I. and Hummel, F. and Wiesner, B. and Janz, M. and Jundt, F. and Hirsch, B. and Joehrens-Leder, K. and Vornlocher, H.P. and Bommert, K. and Stein, H. and Doerken, B.
Journal of Experimental Medicine 199 (8): 1041-1052. 19 April 2004

Pharmacokinetics and cellular uptake of imatinib and its main metabolite CGP74588.
Le Coutre, P. and Kreuzer, K.A. and Pursche, S. and Bonin, M. and Leopold, T. and Baskaynak, G. and Doerken, B. and Ehninger, G. and Ottmann, O. and Jenke, A. and Bornhaeuser, M. and Schleyer, E.
Cancer Chemotherapy and Pharmacology 53 (4): 313-323. 1 April 2004

A novel recombinant bispecific single-chain antibody, bscWue-1 x CD3, induces T-cell-mediated cytotoxicity towards human multiple myeloma cells.
Hoenemann, D. and Kufer, P. and Rimpler, M.M. and Chatterjee, M. and Friedl, S. and Riecher, F. and Bommert, K. and Doerken, B. and Bargou, R.C.
Leukemia 18 (3): 636-644. 1 January 2004

Combined disruption of both the MEK/ERK and the IL-6R/STAT3 pathways is required to induce apoptosis of multiple myeloma cells in the presence of bone marrow stromal cells.
Chatterjee, M. and Stuehmer, T. and Herrmann, P. and Bommert, K. and Doerken, B. and Bargou, R.C.
Blood 104 (12): 3712-3721. 1 January 2004

Differential Emu enhancer activity and expression of BOB.1/OBF.1, Oct2, PU.1, and immunoglobulin in reactive B-cell populations, B-cell non-Hodgkin lymphomas, and Hodgkin lymphomas.
Loddenkemper, C. and Anagnostopoulos, L. and Hummel, M. and Joehrens-Leder, K. and Foss, H.D. and Jundt, F. and Wirth, T. and Doerken, B. and Stein, H.
Journal of Pathology 202 (5): 60-69. 1 January 2004

Downregulation of genes involved in DNA repair and differential expression of transcription regulators and phosphatases precede IgM-induced apoptosis in the Burkitt's lymphoma cell line BL60-2.
Schories, B. and Janz, M. and Doerken, B. and Bommert, K.
Biochimica et Biophysica Acta - Gene Structure and Expression 1676 (1): 83-95. 1 January 2004

Effective use of high-dose chemotherapy and autologous stem cell rescue for relapsed adult Wilms' tumor and a novel alteration in intron 1 of the WT1 gene.
Trappe, R.U. and Riess, H. and Lippek, F. and Plotkin, M. and Schumacher, V. and Royer-Pokora, B. and Hildebrandt, B. and Zuber, J. and Mapara, M.Y. and Oertel, S. and Doerken, B.
Journal of Pediatric Hematology Oncology 26 : 820-823. 1 January 2004

Filgrastim-induced stem cell mobilization in chronic myeloid leukaemia patients during imatinib therapy: safety, feasibility and evidence for an efficient in vivo purging.
Kreuzer, K.A. and Kluehs, C. and Baskaynak, G. and Movassaghi, K. and Doerken, B. and Le Coutre, P.
British Journal of Haematology 124 (2): 195-199. 1 January 2004

Jagged1-induced notch signaling drives proliferation of multiple myeloma cells.
Jundt, F. and Schulze-Proebsting, K. and Anagnostopoulos, I. and Muehlinghaus, G. and Chatterjee, M. and Mathas, S. and Bargou, R.C. and Manz, R. and Stein, H. and Doerken, B.
Blood 103 (9): 3511-3515. 1 January 2004

Nonmyeloablative stem cell transplantation in patients with ALL and AML results in low nonrelapse mortality despite high rate of infections and GVHD.
Massenkeil, G. and Nagy, M. and Le Coutre, P. and Heine, F. and Rosen, O. and Doerken, B. and Arnold, R.
Hematology Journal 5 (5): 395-402. 1 January 2004

PI3-K/AKT/FKHR and MAPK signaling cascades are redundantly stimulated by a variety of cytokines and contribute independently to proliferation and survival of multiple myeloma cells.
Lentzsch, S. and Chatterjee, M. and Gries, M. and Bommert, K. and Gollasch, H. and Doerken, B. and Bargou, R.C.
Leukemia 18 (11): 1883-1890. 1 January 2004

Panhypopituitarism in a patient with breast cancer.
Sturm, I. and Kirschke, S. and Krahl, D. and Doerken, B.
Onkologie 27 : 480-482. 1 January 2004

T-cell-mediated lysis of B cells induced by a CD19xCD3 bispecific single-chain antibody is perforin dependent and death receptor independent.
Gruen, M. and Bommert, K. and Bargou, R.C.
Cancer Immunology Immunotherapy 53 (7): 625-632. 1 January 2004

Cellular senescence in cancer treatment: friend or foe?
Kahlem, P. and Doerken, B. and Schmitt, C.A.
Journal of Clinical Investigation 113 (2): 169-174. January 2004

2003

6-Thioguanine, cytarabine, and daunorubicin (TAD) and high-dose cytarabine and mitoxantrone (HAM) for induction, TAD for consolidation, and either prolonged maintenance by reduced monthly TAD or TAD-HAM-TAD and one course of intensive consolidation by sequential HAM in adult patients at all ages with de novo acute myeloid leukemia (AML): a randomized trial of the German AML Cooperative Group.
Buechner, T. and Hiddemann, W. and Berdel, W.E. and Woermann, B. and Schoch, C. and Fonatsch, C. and Loeffler, H. and Haferlach, T. and Ludwig, W.D. and Maschmeyer, G. and Staib, P. and Aul, C. and Grueneisen, A. and Lengfelder, E. and Frickhofen, N. and Kern, W. and Serve, H.L. and Mesters, R.M. and Sauerland, M.C. and Heinecke, A.
Journal of Clinical Oncology 21 : 4496-4504. 15 December 2003

Clinical research and industrial sponsoring: avenues towards transparency and credibility.
Hildebrandt, M. and Ludwig, W.D.
Onkologie 26 : 529-534. 1 December 2003

The prognostic significance of antigen expression in leukaemia.
Schabath, R. and Ratei, R. and Ludwig, W.D.
Best Practice & Research in Clinical Haematology 16 : 613-628. 1 December 2003

An open label, non-comparative phase II study of topotecan as salvage treatment for patients with soft tissue sarcoma.
Reichardt, P. and Oechsle, K. and Pink, D. and Bokemeyer, C. and Schneller, F. and Issels, R. and Kanz, L. and Hartmann, J.T.
Investigational New Drugs 21 : 481-486. 1 November 2003

Extravasations of oxaliplatin.
Kretzschmar, A. and Pink, D. and Thuss-Patience, P. and Doerken, B. and Reichert, P. and Eckert, R.
Journal of Clinical Oncology 21 (21): 4068-4069. 1 November 2003

Inactivating I kappa B epsilon mutations in Hodgkin/Reed-Sternberg cells.
Emmerich, F. and Theurich, S. and Hummel, M. and Haeffker, A. and Vry, M.S. and Doehner, K. and Bommert, K. and Stein, H. and Doerken, B.
Journal of Pathology 201 (3): 413-420. November 2003

Dynamic expression profile of p21 WAF1/CIP1 and Ki-67 predicts survival in rectal carcinoma treated with preoperative radiochemotherapy.
Rau, B. and Sturm, I. and Lage, H. and Berger, S. and Schneider, U. and Haupfmann, S. and Wust, P. and Riess, H. and Schlag, P.M. and Doerken, B. and Daniel, P.T.
Journal of Clinical Oncology 21 (18): 3391-3401. 15 September 2003

Correlation of protein expression and gene expression in acute leukemia.
Kern, W. and Kohlmann, A. and Wuchter, C. and Schnittger, S. and Schoch, C. and Mergenthaler, S. and Ratei, R. and Ludwig, W.D. and Hiddemann, W. and Haferlach, T.
Cytometry 55B : 29-36. 1 September 2003

Disruption of cell death signaling in cancer: impact on disease prognosis and response to therapy.
Guener, D. and Belka, C. and Daniel, P.T.
Current Medicinal Chemistry Anti-Cancer Agents 3 (5): 319-326. 1 September 2003

Need for safety goggles for endoscopy.
Benter, T. and Kluehs, L. and Teichgraeber, U.K.M. and Riechert, F. and Ludwig, W.D. and Doerken, B.
Endoscopy 35 (9): 803. 1 September 2003

Inhibition of NF-κB essentially contributes to arsenic-induced apoptosis.
Mathas, S. and Lietz, A. and Janz, M. and Hinz, M. and Jundt, F. and Scheidereit, C. and Bommert, K. and Doerken, B.
Blood 102 (3): 1028-1034. 1 August 2003

Oxaliplatin and 5-fluorouracil for heavily pretreated metastatic breast cancer: a preliminary phase II study.
Thuss-Patience, P.C. and von Minckwitz, G. and Kretzschmar, A. and Loibl, S. and Schaller, G. and Doerken, B. and Reichardt, P.
Anti-Cancer Drugs 14 (7): 549-553. 1 August 2003

Recombinant human erythropoietin, epoetin beta, in patients with relapsed lymphoma treated with aggressive sequential salvage chemotherapy - results of a randomized trial.
Glossmann, J.P. and Engert, A. and Wassmer, G. and Flechtner, H. and Ko, Y. and Rudolph, C. and Metzner, B. and Doerken, B. and Wiedenmann, S. and Diehl, V. and Josting, A.
Annals of Hematology 82 (8): 469-475. 1 August 2003

Donor lymphocyte infusion-mediated graft-versus-leukemia effects in mixed chimeras established with a nonmyeloablative conditioning regimen: extinction of graft-versus-leukemia effects after conversion to full donor chimerism.
Mapara, M.Y. and Kim, Y.M. and Marx, J. and Sykes, M.
Transplantation 76 : 297-305. 27 July 2003

Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway.
Gillissen, B. and Essmann, F. and Graupner, V. and Staerck, L. and Radetzki, S. and Doerken, B. and Schulze-Osthoff, K. and Daniel, P.T.
EMBO Journal 22 (14): 3580-3590. 15 July 2003

Central venous access catheters: radiological management of complications.
Teichgraeber, U.K. and Gebauer, B. and Benter, T. and Wagner, H.J.
Cardiovascular and Interventional Radiology 26 : 321-333. 1 July 2003

Chemotherapy in alveolar soft part sarcomas: What do we know?
Reichardt, P. and Lindner, T. and Pink, D. and Thuss-Patience, P.C. and Kretzschmar, A. and Doerken, B.
European Journal of Cancer 39 (11): 1511-1516. 1 July 2003

Standard and increased-dose BEACOPP chemotherapy compared with COPP-ABVD for advanced Hodgkins disease.
Diehl, V. and Franklin, J. and Pfreundschuh, M. and Lathan, B. and Paulus, U. and Hasenclever, D. and Tesch, H. and Herrmann, R. and Doerken, B. and Mueller-Hermelink, H.K. and Duehmke, E. and Loeffler, M.
New England Journal of Medicine 348 (24): 2386-2395. 12 June 2003

CT-gesteuerte bronchoskopische Punktion zur Diagnosesicherung einer hilaeren Raumforderung [CT-controlled bronchoscopic puncture in diagnostic verification of hilar space occupying lesion].
Teichgraeber, U.K. and Gebauer, B. and Benter, T.
RoeFo Fortschritte auf dem Gebiete der Roentgenstrahlen und der neuen bildgebenden Verfahren 175 : 857-858. 1 June 2003

Detection of minimal residual disease in unselected patients with acute myeloid leukemia using multiparameter flow cytometry for definition of leukemia-associated immunophenotypes and determination of their frequencies in normal bone marrow.
Kern, W. and Danhauser-Riedl, S. and Ratei, R. and Schnittger, S. and Schoch, C. and Kolb, H.J. and Ludwig, W.D. and Hiddemann, W. and Haferlach, T.
Haematologica 88 : 646-653. 1 June 2003

Morphologie gastrointestinaler Stromatumoren im fortgeschrittenen Stadium der Erkrankung: Ausgangsbefunde vor Chemotherapie mit Imatinib [Morphology of gastrointestinal stromal tumors in advanced stages of the disease: baseline findings before chemotherapy with imatinib].
Jost, D. and Stroszczynski, C. and Chmelik, P. and Gaffke, G. and Schlecht, I. and Pink, D. and Reichardt, P. and Schneider, U. and Hohenberger, P. and Felix, R.
RoeFo Fortschritte auf dem Gebiete der Roentgenstrahlen und der neuen bildgebenden Verfahren 175 : 791-798. 1 June 2003

Acute hypokalemic tetraparesis induced by intravenous methotrexate.
Thuss-Patience, P.C. and Peters, U. and Jurkat-Rott, K. and Pink, D. and Kretzschmar, A. and Doerken, B. and Reichardt, P.
Journal of Clinical Oncology 21 (9): 1896-1897. 1 May 2003

Macrophage inflammatory protein 1-alpha (MIP-1alpha) triggers migration and signaling cascades mediating survival and proliferation in multiple myeloma (MM) cells.
Lentzsch, S. and Gries, M. and Janz, M. and Bargou, R. and Doerken, B. and Mapara, M.Y.
Blood 101 (9): 3568-3573. 1 May 2003

Efficient elimination of chronic lymphocytic leukaemia B cells by autologous T cells with a bispecific anti-CD19/anti-CD3 single-chain antibody construct.
Loeffler, A. and Gruen, M. and Wuchter, C. and Schriever, F. and Kufer, P. and Dreier, T. and Hanakam, F. and Baeuerle, P.A. and Bommert, K. and Karawajew, L. and Doerken, B. and Bargou, R.C.
Leukemia 17 (5): 900-909. May 2003

Genauigkeit der sonographischen Milzgewichtsbestimmung am Lebenden im Vergleich zum pathologischen Korrelat [Accuracy of the sonographic determination of the splenic weight in comparison with the weight at autopsy].
Kluehs, L. and Teichgraeber, U.K. and Schneider, U. and Ludwig, W.D. and Doerken, B. and Benter, T.
RoeFo Fortschritte auf dem Gebiete der Roentgenstrahlen und der neuen bildgebenden Verfahren 175 (4): 532-535. 1 April 2003

Coexpression of p21WAF1/CIP1 in adenovirus vector transfected human primary hepatocytes prevents apoptosis resulting in improved transgene expression.
Wolff, G. and Schumacher, A. and Nuessler, A.K. and Ruppert, V. and Karawajew, L. and Wehnes, E. and Neuhaus, P. and Doerken, B.
Gene Therapy 10 (8): 668-677. April 2003

Synovialsarkome der Extremitaeten - Ergebnisse chirurgischer und multimodaler Therapie [Synovial sarcoma of the extremities. Results of surgical and multimodal therapy].
Ulmer, C. and Kettelhack, C. and Tunn, P.U. and Reichardt, P. and Hohenberger, P. and Schlag, P.M.
Chirurg 74 (4): 370-374. April 2003

Identification and quantification of in vitro adduct formation between protein reactive xenobiotics and a lysine-containing model peptide.
Reichardt, P. and Schreiber, A. and Wichmann, G. and Metzner, G. and Efer, J. and Raabe, F.
Environmental Toxicology 18 : 29-36. 1 February 2003

Recurrent gastric adenocarcinoma with unusual metastatic localization and excellent response to docetaxel and 5-FU continuous infusion.
Thuss-Patience, P.C. and Kretzschmar, A. and Krenn, V. and Doerken, B. and Reichardt, P.
Onkologie 26 (1): 63-65. 1 February 2003

Chemotherapy response and resistance.
Lee, S. and Schmitt, C.A.
Current Opinion in Genetics & Development 13 (1): 90-96. February 2003

Identifikation Apoptose-assoziierter Gene in B-Zellen und Charakterisierung des Genproduktes LAPTM5.
Schneider, H.
UNSPECIFIED thesis, UNSPECIFIED. 16 January 2003

Morphologic dysplasia in de novo acute myeloid leukemia (AML) is related to unfavorable cytogenetics but has no independent prognostic relevance under the conditions of intensive induction therapy: results of a multiparameter analysis from the German AML Cooperative Group studies.
Haferlach, T. and Schoch, C. and Loeffler, H. and Gassmann, W. and Kern, W. and Schnittger, S. and Fonatsch, C. and Ludwig, W.D. and Wuchter, C. and Schlegelberger, B. and Staib, P. and Reichle, A. and Kubica, U. and Eimermacher, H. and Balleisen, L. and Grueneisen, A. and Haase, D. and Aul, C. and Karow, J. and Lengfelder, E. and Woermann, B. and Heinecke, A. and Sauerland, M.C. and Buechner, T. and Hiddemann, W.
Journal of Clinical Oncology 21 : 256-265. 15 January 2003

Immunomodulatory analogs of thalidomide inhibit growth of Hs Sultan cells and angiogenesis in vivo.
Lentzsch, S. and LeBlanc, R. and Podar, K. and Davies, F. and Lin, B. and Hideshima, T. and Catley, L. and Stirling, D.I. and Anderson, K.C.
Leukemia 17 : 41-44. 1 January 2003

The Golgi protein RCAS1 controls cell surface expression of tumor-associated O-linked glycan antigens.
Engelsberg, A. and Hermosilla, R. and Karsten, U. and Schuelein, R. and Doerken, B. and Rehm, A.
Journal of Biological Chemistry 278 (25): 22998-23007. 1 January 2003

2002

Alveolar rhabdomyosarcoma with bone marrow infiltration mimicking haematological neoplasia.
Maywald, O. and Metzgeroth, G. and Schoch, C. and Ludwig, W.D. and Neff, W. and Hehlmann, R. and Hastka, J.
British Journal of Haematology 119 : 583. 1 December 2002

Analysis of T-cell receptor V-beta 2 in peripheral blood lymphocytes as a diagnostic marker for Kawasaki disease.
Reichardt, P. and Lehmann, I. and Sierig, G. and Borte, M.
Infection 30 : 360-364. 1 December 2002

Die Rolle der Polychemotherapie im multimodalen Behandlungskonzept der malignen Knochentumoren [The role of polychemotherapy in the management of malignant bone tumors].
Reichardt, P. and Doerken, B.
Chirurg 73 (12): 1170-1173. 1 December 2002

Oral trofosfamide: an active and well-tolerated maintenance therapy for adult patients with advanced bone and soft tissue sarcomas. Results of a retrospective analysis.
Reichardt, P. and Pink, D. and Tilgner, J. and Kretzschmar, A. and Thuss-Patience, P.C. and Doerken, B.
Onkologie 25 (6): 541-546. 1 December 2002

In the presence of bone marrow stromal cells human multiple myeloma cells become independent of the IL-6/gp 130/STAT3 pathway.
Chatterjee, M. and Hoenemann, D. and Lentzsch, S. and Bommert, K. and Sers, C. and Herrmann, P. and Mathas, S. and Doerken, B. and Bargou, R.C.
Blood 100 (9): 3311-3318. 1 November 2002

Adenoviral transduction of tumor cells induces apoptosis in co-cultured T lymphocytes.
Scholz, C. and Staerck, L. and Willimsky, G. and Blankenstein, T. and Doerken, B. and Daniel, P.T.
Gene Therapy 9 (21): 1438-1446. November 2002

Akute lymphatische Leukaemie des Erwachsenen. Diagnostik, Risikogruppen und Therapie [Acute lymphatic leukemia in the adult. Diagnosis, risk groups and therapy].
Hoelzer, D. and Arnold, R. and Bartram, C.R. and Bohme, A. and Freund, M. and Ganser, A. and Kneba, M. and Lipp, T. and Ludwig, W.D. and Maschmeyer, G. and Rieder, H. and Thiel, E. and Messerer, D. and Weiss, A. and Goekbuget, N.
Internist 43 : 1212-22, 1224. 1 October 2002

Flow cytometric immunophenotyping of acute lymphoblastic leukemia: is the time ready for consensus the guidelines?
Basso, G. and Lanza, F. and Orfao, A. and Bene, M. and Borowitz, M. and Campana, D. and Lacombe, F. and Ludwig, W.D. and Porwitt-MacDonald, A. and Rothe, G. and Dworzac, M.
Journalof Biological Regulators and Homeostatic Agents 16 : 257-258. 1 October 2002

Karyotype instability between diagnosis and relapse in 117 patients with acute myeloid leukemia: implications for resistance against therapy.
Kern, W. and Haferlach, T. and Schnittger, S. and Ludwig, W.D. and Hiddemann, W. and Schoch, C.
Leukemia 16, 10 : 2084-2091. 1 October 2002

Time-intensified dexamethasone/cisplatin/cytarabine: an effective salvage therapy with low toxicity in patients with relapsed and refractory Hodgkin's disease.
Josting, A. and Rudolph, C. and Reiser, M. and Mapara, M. and Sieber, M. and Kirchner, H.H. and Doerken, B. and Hossfeld, D.K. and Diehl, V. and Engert, A.
Annals of Oncology 13 (10): 1628-1635. October 2002

Nuclear factor κB-dependent gene expression profiling of Hodgkins disease tumor cells, pathogenetic significance, and link to constitutive signal transducer and activator of transcription 5a activity.
Hinz, M. and Lemke, P. and Anagnostopoulos, I. and Hacker, C. and Krappmann, D. and Mathas, S. and Doerken, B. and Zenke, M. and Stein, H. and Scheidereit, C.
Journal of Experimental Medicine 196 (5): 605-617. 2 September 2002

Donor lymphocyte infusions mediate superior graft-versus-leukemia effects in mixed compared to fully allogeneic chimeras: a critical role for host antigen-presenting cells.
Mapara, M.Y. and Kim, Y.M. and Wang, S.P. and Bronson, R. and Sachs, D.H. and Sykes, M.
Blood 100 : 1903-1909. 1 September 2002

Infant acute lymphoblastic leukemia - combined cytogenetic, immunophenotypical and molecular analysis of 77 cases.
Borkhardt, A. and Wuchter, C. and Viehmann, S. and Pils, S. and Teigler-Schlegel, A. and Stanulla, M. and Zimmermann, M. and Ludwig, W.D. and Janka-Schaub, G. and Schrappe, M. and Harbott, J.
Leukemia 16, 9 : 1685-1690. 1 September 2002

Proteasome inhibitor PS-341 inhibits human myeloma cell growth in vivo and prolongs survival in a murine model.
LeBlanc, R. and Catley, L.P. and Hideshima, T. and Lentzsch, S. and Mitsiades, C.S. and Mitsiades, N. and Neuberg, D. and Goloubeva, O. and Pien, C.S. and Adams, J. and Gupta, D. and Richardson, P.G. and Munshi, N.C. and Anderson, K.C.
Cancer Research 62 (17): 4996-5000. 1 September 2002

The vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584 inhibits growth and migration of multiple myeloma cells in the bone marrow microenvironment.
Lin, B. and Podar, K. and Gupta, D. and Tai, Y.T. and Li, S. and Weller, E. and Hideshima, T. and Lentzsch, S. and Davies, F. and Li, C. and Weisberg, E. and Schlossman, R.L. and Richardson, P.G. and Griffin, J.D. and Wood, J. and Munshi, N.C. and Anderson, K.C.
Cancer Research 62 : 5019-5026. 1 September 2002

Extremely potent, rapid and costimulation-independent cytotoxic T-cell response against lymphoma cells catalyzed by a single-chain bispecific antibody.
Dreier, T. and Lorenczewski, G. and Brandl, C. and Hoffmann, P. and Syring, U. and Hanakam, F. and Kufer, P. and Riethmuller, G. and Bargou, R. and Baeuerle, P.A.
International Journal of Cancer 100 (6): 690-697. 20 August 2002

Laser-induzierte Thermotherapie (LITT) bei malignen Lebertumoren: Einsatz der Sonographie zur Katheterplatzierung und Prozessbeobachtung [Laser-induced thermotherapy (LITT) for malignant liver tumours: the role of sonography in catheter placement and observation of the therapeutic procedure].
Stroszczynski, C. and Gretschel, S. and Gaffke, G. and Puls, R. and Kretzschmar, A. and Hosten, N. and Schlag, P.M. and Felix, R.
Ultraschall in der Medizin 23 (3): 163-167. 8 August 2002

Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B.
Mathas, S. and Hinz, M. and Anagnostopoulos, L. and Krappmann, D. and Lietz, A. and Jundt, F. and Bommert, K. and Mechta-Grigoriou, F. and Stein, H. and Doerken, B. and Scheidereit, C.
EMBO Journal 21 (15): 4104-4113. 1 August 2002

In vitro drug resistance profile of Philadelphia positive acute lymphoblastic leukemia is heterogeneous and related to age: a report of the Dutch and German Leukemia Study Groups.
Ramakers-van Woerden, N.L. and Pieters, R. and Hoelzer, D. and Slater, R.M. and den Boer, M.L. and Loonen, A.H. and Harbott, J. and Janka-Schaub, G.E. and Ludwig, W.D. and Ossenkoppele, G.J. and van Wering, E.R. and Veerman, A.J.
Medical and Pediatric Oncology 38 : 379-386. 1 June 2002

In vitro susceptibility to dexamethasone- and doxorubicin-induced apoptotic cell death in context of maturation stage, responsiveness to interleukin 7, and early cytoreduction in vivo in childhood T-cell acute lymphoblastic leukemia.
Wuchter, C. and Ruppert, V. and Schrappe, M. and Doerken, B. and Ludwig, W.D. and Karawajew, L.
Blood 99 (11): 4109-4115. 1 June 2002

Assessment of genomic instability in breast cancer and uveal melanoma by random amplified polymorphic DNA analysis.
Papadopoulos, S. and Benter, T. and Anastassiou, G. and Pape, M. and Gerhard, S. and Bornfeld, N. and Ludwig, W.D. and Doerken, B.
International Journal of Cancer 99 (2): 193-200. 10 May 2002

A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy.
Schmitt, C.A. and Fridman, J.S. and Yang, M. and Lee, S. and Baranov, E. and Hoffman, R.M. and Lowe, S.W.
Cell 109 (3): 335-346. 3 May 2002

Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma.
Jundt, F. and Anagnostopoulos, I. and Foerster, R. and Mathas, S. and Stein, H. and Doerken, B.
Blood 99 (9): 3398-3403. 1 May 2002

Hepatocarcinoma cells constitutively expressing adenoviral E1-genes provide a tumor model for intratumoral replication of E1-deficient adenoviruses.
Cichon, G. and Boeckh-Herwig, S. and Elezkurtaj, S. and Schmidt, H.H. and Hofmann, C. and Arnold, W.
Anticancer Research 22 (1A): 197-201. May 2002

Human cytomegalovirus gene products US2 and US11 differ in their ability to attack major histocompatibility class I heavy chains in dendritic cells.
Rehm, A. and Engelsberg, A. and Tortorella, D. and Koerner, I.J. and Lehmann, I. and Ploegh, H.L. and Hoepken, U.E.
Journal of Virology 76 (10): 5043-5050. May 2002

Loss of PU.1 expression is associated with defective immunoglobulin transcription in Hodgkin and Reed-Sternberg cells of classical Hodgkin disease.
Jundt, F. and Kley, K. and Anagnostopoulos, I. and Schulze-Proebsting, K. and Greiner, A. and Mathas, S. and Scheidereit, C. and Wirth, T. and Stein, H. and Doerken, B.
Blood 99 (8): 3060-3062. 15 April 2002

S-3-Amino-phthalimido-glutarimide inhibits angiogenesis and growth of B-cell neoplasias in mice.
Lentzsch, S. and Rogers, M.S. and LeBlanc, R. and Birsner, A.E. and Shah, J.H. and Treston, A.M. and Anderson, K.C. and D'Amato, R.J.
Cancer Research 62 : 2300-2305. 15 April 2002

Dissecting p53 tumor suppressor functions in vivo.
Schmitt, C.A. and Fridman, J.S. and Yang, M. and Baranov, E. and Hoffman, R.M. and Lowe, S.W.
Cancer Cell 1 (3): 289-298. 1 April 2002

Morphologic diagnosis of leukaemic B-lymphoproliferative disorders and the role of cyclin D1 expression.
Oertel, J. and Kingreen, D. and Busemann, C. and Stein, H. and Doerken, B.
Journal of Cancer Research and Clinical Oncology 128 (4): 182-188. April 2002

Acute myeloid leukemia: treatment over 60.
Buechner, T. and Hiddemann, W. and Berdel, W. and Woermann, B. and Schoch, C. and Loffler, H. and Haferlach, T. and Schumacher, A. and Staib, P. and Balleisen, L. and Gruneisen, A. and Rasche, H. and Aul, C. and Heyll, A. and Lengfelder, E. and Ludwig, W.D. and Maschmeyer, G. and Eimermacher, H. and Karow, J. and Frickhofen, N. and Hirschmann, W.D. and Sauerland, M.C.
Reviews in Clinical and Experimental Hematology 6, 1 : 46-59. 1 March 2002

Apoptosis and chemoresistance in transgenic cancer models.
Schmitt, C.A. and Lowe, S.W.
Journal of Molecular Medicine 80 (3): 137-146. March 2002

Infection of cells with replication deficient adenovirus induces cell cycle alterations and leads to downregulation of E2F-1.
Kuhn, H. and Liebers, U. and Gessner, C. and Karawajew, L. and Ruppert, V. and Schumacher, A. and Witt, C. and Wolff, G.
Biochimica et Biophysica Acta 1542 : 106-115. 30 January 2002

Adenovirus-mediated gene transfer of P161NK4/CDKN2 into bax-negative colon cancer cells induces apoptosis and tumor regression in vivo.
Tamm, I. and Schumacher, A. and Karawajew, L. and Ruppert, V. and Arnold, W. and Nuessler, A.K. and Neuhaus, P. and Doerken, B. and Wolff, G.
Cancer Gene Therapy 9 : 641-650. 1 January 2002

BALTOMe - ein Langzeitverlauf [BALTOMA - long-term follow-up].
Gaffke, G. and Stroszczynski, C. and Ludwig, W.D. and Puls, R. and Schlecht, I. and Jost, D. and Hosten, N. and Felix, R.
Roentgenpraxis 54 (5): 186-191. 1 January 2002

Diagnostik von Duenndarmtumoren mit Hilfe des CT-Enteroklysma. Die CT--Sellink ausgewertet bei 63 Patienten [Diagnosis of tumors of the small intestine with the aid of CT contrast enema. Sellink CT technique evaluated in 63 patients].
Gaffke, G. and Stroszczynski, C. and Schlecht, I. and Jost, D. and Ludwig, W.D. and Schlag, P.M. and Felix, R.
Roentgenpraxis 54 (6): 214-219. 1 January 2002

Sp1 as G1 cell cycle phase specific transcription factor in epithelial cells.
Grinstein, E. and Jundt, F. and Weinert, I. and Wernet, P. and Royer, H.D.
Oncogene 21 : 1485-1492. 1 January 2002

Surface expression and endocytosis of the human cytomegalovirus-encoded chemokine receptor US28 is regulated by agonist-independent phosphorylation.
Mokros, T. and Rehm, A. and Droese, J. and Oppermann, M. and Lipp, M. and Hoepken, U.E.
Journal of Biological Chemistry 277 (47): 45122-45128. 1 January 2002

Y-box factor YB-1 predicts drug resistance and patient outcome in breast cancer independent of clinically relevant tumor biologic factors HER2, uPA and PAI-1.
Janz, M. and Harbeck, N. and Dettmar, P. and Berger, U. and Schmidt, A. and Juerchott, K. and Schmitt, M. and Royer, H.D.
International Journal of Cancer 97 (3): 278-282. 1 January 2002

Therapie eines Zenker'schen Divertikels [Therapy of Zenker's divertikulum].
Benter, T. and Kretzschmar, A. and Reich, G. and Papadopoulos, S. and Kluhs, L. and Ludwig, W.D. and Doerken, B.
Medizinische Klinik 97 (1): 44-45. January 2002

2001

Adherence of multiple myeloma cells to bone marrow stromal cells upregulates vascular endothelial growth factor secretion: therapeutic applications.
Gupta, D. and Treon, S.P. and Shima, Y. and Hideshima, T. and Podar, K. and Tai, Y.T. and Lin, B. and Lentzsch, S. and Davies, F.E. and Chauhan, D. and Schlossman, R.L. and Richardson, P. and Ralph, P. and Wu, L. and Payvandi, F. and Muller, G. and Stirling, D.I. and Anderson, K.C.
Leukemia 15 : 1950-1961. 1 December 2001

Cytogenetic and molecular characterization of a patient with simultaneous B-cell chronic lymphocytic leukemia and peripheral T-cell lymphoma.
Martin-Subero, J.I. and Siebert, R. and Harder, L. and Gesk, S. and Schwindt, P. and Braeuninger, A. and Willenbrock, K. and Steinemann, D. and Tiemann, M. and Calasanz, M.J. and Grote, W. and Ludwig, W.D. and Hansmann, M.L. and Schlegelberger, B.
American Journal of Hematology 68 : 276-279. 1 December 2001

Mechanism of action of thalidomide and 3-aminothalidomide in multiple myeloma.
D'Amato, R.J. and Lentzsch, S. and Anderson, K.C. and Rogers, M.S.
Seminars in Oncology 28, 6 : 597-601. 1 December 2001

Piceatannol, a hydroxylated analog of the chemopreventive agent resveratrol, is a potent inducer of apoptosis in the lymphoma cell line BJAB and in primary, leukemic lymphoblasts.
Wieder, T. and Prokop, A. and Bagci, B. and Essmann, F. and Bernicke, D. and Schulze-Osthoff, K. and Doerken, B. and Schmalz, H.G. and Daniel, P.T. and Henze, G.
Leukemia 15 (11): 1735-1742. 1 November 2001

Polypoide Magenbeteiligung beim Plasmozytom [Polypoid gastric involvement in plasmacytoma].
Benter, T. and Kluehs, L. and Gabor, C. and Spahn, G. and Doerken, B.
Medizinische Klinik 96 (8): 489-490. 15 August 2001

Antisense therapy in oncology: new hope for an old idea?
Tamm, I. and Doerken, B. and Hartmann, G.
Lancet 358 (9280): 489-497. 11 August 2001

Remission induction therapy: the more intensive the better?
Buechner, T. and Hiddemann, W. and Berdel, W. and Woermann, B. and Loeffler, H. and Schoch, C. and Haferlach, T. and Ludwig, W.D. and Maschmeyer, G. and Staib, P. and Andreesen, R. and Balleisen, L. and Haase, D. and Eimermacher, H. and Aul, C. and Rasche, H. and Uhlig, J. and Grueneisen, A. and Reis, H.E. and Hartlapp, J. and Hirschmann, W.D. and Weh, H.J. and Pielken, H.J. and Gassmann, W. and Sauerland, M.C. and Heinecke, A.
Cancer Chemotherapy and Pharmacology 48 Suppl 1 : S41-S44. 1 August 2001

The Bax/Bcl-2 ratio determines the susceptibility of human melanoma cells to CD95/Fas-mediated apoptosis.
Raisova, M. and Hossini, A.M. and Eberle, J. and Riebeling, C. and Wieder, T. and Sturm, I. and Daniel, P.T. and Orfanos, C.E. and Geilen, C.C.
Journal of Investigative Dermatology 117 (2): 333-340. 1 August 2001

The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia.
Fuchs, U. and Rehkamp, G. and Haas, O.A. and Slany, R. and Konig, M. and Bojesen, S. and Bohle, R.M. and Damm-Welk, C. and Ludwig, W.D. and Harbott, J. and Borkhardt, A.
Proceedings of the National Academy of Sciences of the United States of America 98 (15): 8756-8761. 17 July 2001

Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration.
Podar, K. and Tai, Y.T. and Davies, F.E. and Lentzsch, S. and Sattler, M. and Hideshima, T. and Lin, B.K. and Gupta, D. and Shima, Y. and Chauhan, D. and Mitsiades, C. and Raje, N. and Richardson, P. and Anderson, K.C.
Blood 98 (2): 428-435. 15 July 2001

Oncolytic viruses as therapeutic agents.
Wildner, O.
Annals of Medicine 33 : 291-304. 1 July 2001

Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma.
Davies, F.E. and Raje, N. and Hideshima, T. and Lentzsch, S. and Young, G. and Tai, Y.T. and Lin, B. and Podar, K. and Gupta, D. and Chauhan, D. and Treon, S.P. and Richardson, P.G. and Schlossman, R.L. and Morgan, G.J. and Muller, G.W. and Stirling, D.I. and Anderson, K.C.
Blood 98 (1): 210-216. 1 July 2001

The kiss of death: promises and failures of death receptors and ligands in cancer therapy.
Daniel, P.T. and Wieder, T. and Sturm, I. and Schulze-Osthoff, K.
Leukemia 15 (7): 1022-1032. 1 July 2001

Verfahren zur Verbesserung des Gentransfers von genetischem Material in Saeugerzellen durch die Verwendung von P21 (WAF-1) [Method for improving the gene transfer of genetic material in mammalian cells through the use of P21 (WAF-1)].
Doerken, B. and Wolff, G. and Schumacher, A.
EP1097234. 13 June 2001

Overexpression of caspase-3 restores sensitivity for drug-induced apoptosis in breast cancer cell lines with acquired drug resistance.
Friedrich, K. and Wieder, T. and von Haefen, C. and Radetzki, S. and Jaenicke, R. and Schulze-Osthoff, K. and Doerken, B. and Daniel, P.T.
Oncogene 20 (22): 2749-2760. 17 May 2001

Spectral karyotyping and fluorescence in situ hybridization detect novel chromosomal aberrations, a recurring involvement of chromosome 21 and amplification of the MYC oncogene in acute myeloid leukaemia M2.
Hilgenfeld, E. and Padilla-Nash, H. and McNeil, N. and Knutsen, T. and Montagna, C. and Tchinda, J. and Horst, J. and Ludwig, W.D. and Serve, H. and Buechner, T. and Berdel, W.E. and Schroeck, E. and Ried, T.
British Journal of Haematology 113 : 305-317. 1 May 2001

Signal peptide cleavage of a type I membrane protein, HCMV US11, is dependent on its membrane anchor.
Rehm, A. and Stern, P. and Ploegh, H.L. and Tortorella, D.
EMBO Journal 20 (7): 1573-1582. 2 April 2001

Apoptosis is critical for drug response in vivo.
Schmitt, C.A. and Lowe, S.W.
Drug Resistance Updates 4 (2): 132-134. April 2001

Activation of caspase-8 in drug-induced apoptosis of B-lymphoid cells is independent of CD95/Fas receptor-ligand interaction and occurs downstream of caspase-3.
Wieder, T. and Essmann, F. and Prokop, A. and Schmelz, K. and Schulze-Osthoff, K. and Beyaert, R. and Doerken, B. and Daniel, P.T.
Blood 97 (5): 1378-1387. 1 March 2001

Infectious complications after high-dose chemotherapy and autologous stem cell transplantation: comparison between patients with lymphoma or multiple myeloma and patients with solid tumors.
Reich, G. and Mapara, M.Y. and Reichardt, P. and Doerken, B. and Maschmeyer, G.
Bone Marrow Transplantation 27 : 525-529. 1 March 2001

Gene transfer of heat-shock protein 70 reduces infarct size in vivo after ischemia/reperfusion in the rabbit heart.
Okubo, S. and Wildner, O. and Shah, M.R. and Chelliah, J.C. and Hess, M.L. and Kukreja, R.C.
Circulation 103 (6): 877-881. 13 February 2001

Four patients with AL amyloidosis treated with high-dose chemotherapy and autologous stem cell transplantation.
Reich, G. and Held, T. and Siegert, W. and Kampf, D. and Doerken, B. and Maschmeyer, G.
Bone Marrow Transplantation 27 : 341-343. 1 February 2001

Anatomical variations in the internal jugular veins of cancer patients affecting central venous access. Anatomical variation of the internal jugular vein.
Benter, T. and Teichgraeber, U.K. and Kluehs, L. and Papadopoulos, S. and Koehne, C.H. and Felix, R. and Doerken, B.
Ultraschall in der Medizin 22 (1): 23-26. February 2001

Acute myeloid leukaemia MO: haematological, immunophenotypic and cytogenetic characteristics and their prognostic significance: an analysis in 241 patients.
Bene, M.C. and Bernier, M. and Casasnovas, R.O. and Castoldi, G. and Doekharan, D. and van der Holt, B. and Knapp, W. and Lemez, P. and Ludwig, W.D. and Matutes, E. and Orfao, A. and Schoch, C. and Sperling, C. and van't Veer, M.B.
British Journal of Haematology 113 : 737-745. 1 January 2001

Analysis of p53/BAX/p16(ink4a/CDKN2) in esophageal squamous cell carcinoma: High BAX and p16(nk4a/CDKN2) identifies patients with good prognosis.
Sturm, I. and Petrowsky, H. and Volz, R. and Lorenz, M. and Radetzki, S. and Hillebrand, T. and Wolff, G. and Hauptmann, S. and Doerken, B. and Daniel, P.T.
Journal of Clinical Oncology 19 : 2272-2281. 1 January 2001

Apoptotic response to homoharringtonine in human wt p53 leukemic cells is independent of reactive oxygen species generation and implicates Bax translocation, mitochondrial cytochrome c release and caspase activation.
Cai, Z. and Lin, M. and Wuchter, C. and Ruppert, V. and Doerken, B. and Ludwig, W.D. and Karawajew, L.
Leukemia 15 : 567-574. 1 January 2001

Bax expression in benign and malignant thyroid tumours: dysregulation of wild-type p53 is associated with a high bax and p21 expression in thyroid carcinoma.
Hermann, S. and Sturm, I. and Mrozek, A. and Klosterhalfen, B. and Hauptmann, S. and Doerken, B. and Daniel, P.T.
International Journal of Cancer 92 (6): 805-811. 1 January 2001

Cleavage and shedding of E-cadherin after induction of apoptosis.
Steinhusen, U. and Weiske, J. and Badock, V. and Tauber, R. and Bommert, K. and Huber, O.
Journal of Biological Chemistry 276 (7): 4972-4980. 1 January 2001

Constitutive NF-kappaB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells.
Hinz, M. and Loeser, P. and Mathas, S. and Krappmann, D. and Doerken, B. and Scheidereit, C.
Blood 97 (9): 2798-2807. 1 January 2001

Decreased generation of anti-tumor immunity after intrasplenic immunization.
Cayeux, S. and Qin, Z.H. and Doerken, B. and Blankenstein, T.
European Journal of Immunology 31 (5): 1392-1399. 1 January 2001

Expansion of hepatic and hematopoietic stem cells utilizing mouse embryonic liver explants.
Monga, S.P. and Tang, Y. and Candotti, F. and Rashid, A. and Wildner, O. and Mishra, B. and Iqbal, S. and Mishra, L.
Cell Transplantation 10 : 81-89. 1 January 2001

Favorable outcome for children and adolescents with T-cell lymphoblastic lymphoma with an intensive ALL-type therapy without local radiotherapy.
Grenzebach, J. and Schrappe, M. and Ludwig, W.D. and Parwaresch, R. and Zimmermann, M. and Gadner, H. and Riehm, H. and Reiter, A.
Annals of Hematology 80 Suppl 3 : B73-B76. 1 January 2001

Impact of CD133 (AC133) and CD90 expression analysis for acute leukemia immunophenotyping.
Wuchter, C. and Ratei, R. and Spahn, G. and Schoch, C. and Harbott, J. and Schnittger, S. and Haferlach, T. and Creutzig, U. and Sperling, C. and Karawajew, L. and Ludwig, W.D.
Haematologica 86 : 154-161. 1 January 2001

Induction of stable long-term mixed hematopoietic chimerism following nonmyeloablative conditioning with T cell-depleting antibodies, cyclophosphamide, and thymic irradiation leads to donor-specific in vitro and in vivo tolerance.
Mapara, M.Y. and Pelot, M. and Zhao, G. and Swenson, K. and Pearson, D. and Sykes, M.
Biology of Blood and Marrow Transplantation 7 : 646-655. 1 January 2001

Involvement of BCL-2 and Bax in the IL-3-induced inhibition of spontaneous apoptosis in childhood T-ALL.
Ruppert, V. and Wuchter, C. and Doerken, B. and Ludwig, W.D. and Karawajew, L.
In: Acute Leukemias VIII: Prognostic Factors and Treatment Strategies. Haematologie und Bluttransfusion ; 40 . Springer, Berlin, 128-135. ISBN 3-540-41123-2 1 January 2001

Prefractionation of protein samples for proteome analysis using reversed-phase high-performance liquid chromatography.
Badock, V. and Steinhusen, U. and Bommert, K. and Otto, A.
Electrophoresis 22 (14): 2856-2864. 1 January 2001

Relevance of Ki-67 antigen expression and K-ras mutation in colorectal liver metastases.
Petrowsky, H. and Sturm, I. and Graubitz, O. and Kooby, D.A. and Staib-Sebler, E. and Gog, C. and Koehne, C.H. and Hillebrand, T. and Daniel, P.T. and Fong, Y. and Lorenz, M.
European Journal of Surgical Oncology 27 (1): 80-87. 1 January 2001

The IL-6 receptor antagonist SANT-7 overcomes bone marrow stromal cell-mediated drug resistance of multiple myeloma cells.
Hoenemann, D. and Chatterjee, M. and Savino, R. and Bommert, K. and Burger, R. and Gramatzki, M. and Doerken, B. and Bargou, R.C.
International Journal of Cancer 93 (5): 674-680. 1 January 2001

Bcl-2 mediates chemoresistance in matched pairs of primary Emu-myc lymphomas in vivo.
Schmitt, C.A. and Lowe, S.W.
Blood Cells Molecules and Diseases 27 (1): 206-216. January 2001

2000

Long-term results of four consecutive trials in childhood ALL performed by the ALL-BFM study group from 1981 to 1995. Berlin-Frankfurt-Munster.
Schrappe, M. and Reiter, A. and Zimmermann, M. and Harbott, J. and Ludwig, W.D. and Henze, G. and Gadner, H. and Odenwald, E. and Riehm, H.
Leukemia 14 (12): 2205-2222. 1 December 2000

Treatment of Adult ALL according to protocols of the German Multicenter Study Group for Adult ALL (GMALL).
Goekbuget, N. and Hoelzer, D. and Arnold, R. and Boehme, A. and Bartram, C.R. and Freund, M. and Ganser, A. and Kneba, M. and Langer, W. and Lipp, T. and Ludwig, W.D. and Maschmeyer, G. and Rieder, H. and Thiel, E. and Weiss, A. and Messerer, D.
Hematology/Oncology Clinics of North America 14 : 1307-1325. 1 December 2000

Salvage therapy for relapsed mediastinal B-cell lymphoma with allogeneic HLA-identical related donor bone marrow transplantation, donor lymphocyte infusion and IDEC-C2B8.
Ratei, R. and Matylis, A. and Krahl, D. and Arnold, R. and Stein, H. and Doerken, B. and Ludwig, W.D.
Leukemia & Lymphoma 40 (1-2): 133-140. December 2000

Acute myeloid leukemia in adults: is postconsolidation maintenance therapy necessary?
Buechner, T. and Hiddemann, W. and Woermann, B. and Loeffler, H. and Ludwig, W.D. and Schoch, C. and Haferlach, T. and Maschmeyer, G. and Staib, P. and Aul, C. and Heyll, G.A. and Gruneisen, A. and Rasche, H. and Eimermacher, J.H. and Balleisen, L. and Pielken, H.J. and Reis, H.E. and Griesinger, F. and Reichle, A. and Sauerland, M.C. and Heinecke, A.
International Journal of Hematology 72 : 285-289. 1 October 2000

Genetic analysis of chemoresistance in primary murine lymphomas.
Schmitt, C.A. and Rosenthal, C.T. and Lowe, S.W.
Nature Medicine 6 : 1029-1035. 1 September 2000

Relapse in childhood acute lymphoblastic leukemia is associated with a decrease of the Bax/Bcl-2 ratio and loss of spontaneous caspase-3 processing in vivo.
Prokop, A. and Wieder, T. and Sturm, I. and Essmann, F. and Seeger, K. and Wuchter, C. and Ludwig, W.D. and Henze, G. and Doerken, B. and Daniel, P.T.
Leukemia 14 : 1606-1613. 1 September 2000

Therapy of peritoneal carcinomatosis from colon cancer with oncolytic adenoviruses.
Wildner, O. and Morris, J.C.
Journal of Gene Medicine 2 (5): 353-360. 1 September 2000

Impaired bax protein expression in breast cancer: mutational analysis of the bax and the p53 gene.
Sturm, I. and Papadopoulos, S. and Hillebrand, T. and Benter, T. and Luck, H.J. and Wolff, G. and Doerken, B. and Daniel, P.T.
International Journal of Cancer 87 : 517-521. 15 August 2000

Double induction strategy including high dose cytarabine in combination with all-trans retinoic acid: effects in patients with newly diagnosed acute promyelocytic leukemia. German AML Cooperative Group.
Lengfelder, E. and Reichert, A. and Schoch, C. and Haase, D. and Haferlach, T. and Loeffler, H. and Staib, P. and Heyll, A. and Seifarth, W. and Saussele, S. and Fonatsch, C. and Gassmann, W. and Ludwig, W.D. and Hochhaus, A. and Beelen, D. and Aul, C. and Sauerland, M.C. and Heinecke, A. and Hehlmann, R. and Woermann, B. and Hiddemann, W. and Buechner, T.
Leukemia 14 : 1362-1370. 1 August 2000

Oral trofosfamide in elderly and/or heavily pretreated patients with metastatic lung cancer.
Horvath, V. and Hartlapp, J.H. and Hegewisch-Becker, S. and Feyerabend, T. and von Weikersthal, L.F. and Illiger, H.J. and Jaeger, E. and Peters, S.O. and Reichardt, P. and Uthgenannt, D. and Weber, K. and Wagner, T. and Wiedemann, G.J. and Zschaber, R.
Onkologie 23 : 341-344. 1 August 2000

The role of the E1B 55 kDa gene product in oncolytic adenoviral vectors expressing herpes simplex virus-tk: Assessment of antitumor efficacy and toxicity.
Wildner, O. and Morris, J.C.
Cancer Research 60 (15): 4167-4174. 1 August 2000

Clinical significance of P-glycoprotein expression and function for response to induction chemotherapy, relapse rate and overall survival in acute leukemia.
Wuchter, C. and Karawajew, L. and Ruppert, V. and Schrappe, M. and Buechner, T. and Schoch, C. and Haferlach, T. and Harbott, J.N. and Ratei, R. and Doerken, B. and Ludwig, W.D.
Haematologica 85 : 711-721. 1 July 2000

Constitutive expression levels of CD95 and Bcl-2 as well as CD95 function and spontaneous apoptosis in vitro do not predict the response to induction chemotherapy and relapse rate in childhood acute lymphoblastic leukaemia.
Wuchter, C. and Karawajew, L. and Ruppert, V. and Schrappe, M. and Harbott, J. and Ratei, R. and Doerken, B. and Ludwig, W.D.
British Journal of Haematology 110 : 154-160. 1 July 2000

Detection of acute leukemia cells with mixed lineage leukemia (MLL) gene rearrangements by flow cytometry using monoclonal antibody 7.1.
Wuchter, C. and Harbott, J. and Schoch, C. and Schnittger, S. and Borkhardt, A. and Karawajew, L. and Ratei, R. and Ruppert, V. and Haferlach, T. and Creutzig, U. and Doerken, B. and Ludwig, W.D.
Leukemia 14 : 1232-1238. 1 July 2000

Inhibition of in vitro spontaneous apoptosis by IL-7 correlates with Bcl-2 up-regulation, cortical/mature immunophenotype, and better early cytoreduction of childhood T-cell acute lymphoblastic leukemia.
Karawajew, L. and Ruppert, V. and Wuchter, C. and Koesser, A. and Schrappe, M. and Doerken, B. and Ludwig, W.D.
Blood 96 : 297-306. 1 July 2000

Precursor B-cell lymphoblastic lymphoma in childhood and adolescence: Clinical features, treatment, and results in trials NHL-BFM 86 and 90.
Neth, O. and Seidemann, K. and Jansen, P. and Mann, G. and Tiemann, M. and Ludwig, W.D. and Riehm, H. and Reiter, A.
Medical and Pediatric Oncology 35 : 20-27. 1 July 2000

Improved outcome in childhood acute lymphoblastic leukemia despite reduced use of anthracyclines and cranial radiotherapy: results of trial ALL-BFM 90. German-Austrian-Swiss ALL-BFM Study Group.
Schrappe, M. and Reiter, A. and Ludwig, W.D. and Harbott, J. and Zimmermann, M. and Hiddemann, W. and Niemeyer, C. and Henze, G. and Feldges, A. and Zintl, F. and Kornhuber, B. and Ritter, J. and Welte, K. and Gadner, H. and Riehm, H.
Blood 95 (11): 3310-3322. 1 June 2000

Ultraschallgesteuerte Punktionstechnik von zentral-venoesen Gefaessen in Ein-Personen-Technik [Ultrasonographically guided puncture technique for central venous vessels as a one-person technique].
Teichgraeber, U.K. and Benter, T. and Schultz, H.J. and Kluehs, L. and Gutberlet, M. and Felix, R.
Ultraschall in der Medizin 21 : 132-136. 1 June 2000

Weekly 24-Hour infusion of high-dose 5-fluorouracil plus folinic acid in combination with mitomycin C for the treatment of advanced gastric cancer.
Kretzschmar, A. and Reichardt, P. and Thuss-Patience, P.C. and Hohenberger, P. and Benter, T. and Doerken, B. and Koehne, C.H.
Oncology 59 (1): 14-17. June 2000

Resistance to CD95/Fas-induced and ceramide-mediated apoptosis of human melanoma cells is caused by a defective mitochondrial cytochrome c release.
Raisova, M. and Bektas, M. and Wieder, T. and Daniel, P. and Eberle, J. and Orfanos, C.E. and Geilen, C.C.
FEBS Letters 473 : 27-32. 4 May 2000

Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias.
Tamm, I. and Kornblau, S.M. and Segall, H. and Krajewski, S. and Welsh, K. and Kitada, S. and Scudiero, D.A. and Tudor, G. and Qui, Y.H. and Monks, A. and Andreeff, M. and Reed, J.C.
Clinical Cancer Research 6 (5): 1796-1803. 1 May 2000

Structurally diverse forms of HLA-B27 molecules are displayed in vivo in a cell type-dependent manner.
Rehm, A. and Rohr, A. and Seitz, C. and Wonigeit, K. and Ziegler, A. and Uchanska-Ziegler, B.
Human Immunology 61 : 408-418. 1 April 2000

Internal gallbladder drainage in a patient with malignant cystic duct stenosis due to sarcoma.
Benter, T. and Kluehs, L. and Teichgraeber, U.K. and Papadopoulos, S. and Meissner, E. and Doerken, B.
Endoscopy 32 (4): S18-S19. April 2000

Verfahren zur Optimierung der Produktion von Adenovirus-Vektoren.
Wolff, G. and Schumacher, A. and Doerken, B.
DE19830907A1 ; EP1097235. 16 March 2000

GDP dissociation inhibitor D4-GDI (Rho-GDI 2), but not the homologous Rho-GDI 1, is cleaved by caspase-3 during drug-induced apoptosis.
Essmann, F. and Wieder, T. and Otto, A. and Mueller, E.C. and Doerken, B. and Daniel, P.T.
Biochemical Journal 346 (3): 777-783. 15 March 2000

A phase I study of intralesional administration of an adenovirus vector expressing the HSV-1 thymidine kinase gene (AdV.RSV-TK) in combination with escalating doses of ganciclovir in patients with cutaneous metastatic malignant melanoma.
Morris, J.C. and Ramsey, W.J. and Wildner, O. and Muslow, H.A. and Aguilar-Cordova, E. and Blaese, R.M.
Human Gene Therapy 11 : 487-503. 10 February 2000

Granulocyte colony-stimulating factor receptor expression and 11q23/MLL genotype in childhood acute lymphoblastic leukemia developing during the first 18 months of life.
Stanulla, M. and Kasper, B. and Schrappe, M. and Viehmann, S. and Harbott, J. and Ludwig, W.D. and Welte, K.
Leukemia 14 : 337-338. 1 February 2000

Structure-dependent effects of glucose-containing analogs of platelet activating factor (PAF) on membrane integrity.
Wiese, A. and Wieder, T. and Mickeleit, M. and Reinoehl, S. and Geilen, C.C. and Seydel, U. and Reutter, W.
Biological Chemistry 381 : 135-144. 1 February 2000

Intensive ALL-type therapy without local radiotherapy provides a 90% event-free survival for children with T-cell lymphoblastic lymphoma: a BFM group report.
Reiter, A. and Schrappe, M. and Ludwig, W.D. and Tiemann, M. and Parwaresch, R. and Zimmermann, M. and Schirg, E. and Henze, G. and Schellong, G. and Gadner, H. and Riehm, H.
Blood 95 : 416-421. 15 January 2000

Verfahren zur Stabilisierung und Verbesserung des Gentransfers von genetischem Material in Saeugerzellen.
Wolff, G. and Schumacher, A. and Doerken, B.
DE19830874A1. 13 January 2000

A recombinant bispecific single-chain antibody, CD19 X CD3, induces rapid and high lymphoma-directed cytotoxicity by unstimulated T lymphocytes.
Loeffler, A. and Kufer, P. and Lutterbuese, R. and Zettl, F. and Daniel, P.T. and Schwenkenbecher, J.M. and Riethmueller, G. and Doerken, B. and Bargou, R.C.
Blood 95 : 2098-2103. 1 January 2000

Anti-CD20-and B-cell receptor-mediated apoptosis: Evidence for shared intracellular signaling pathways.
Mathas, S. and Rickers, A. and Bommert, K. and Doerken, B. and Mapara, M.Y.
Cancer Research 60 (24): 7170-7176. 1 January 2000

Apoptosis-induced cleavage of beta-catenin by caspase-3 results in proteolytic fragments with reduced transactivation potential.
Steinhusen, U. and Badock, V. and Bauer, A. and Behrens, J. and Wittmann-Liebold, B. and Doerken, B. and Bommert, K.
Journal of Biological Chemistry 275 (21): 16345-16353. 1 January 2000

DNA damage responses and chemosensitivity in the E mu-myc mouse lymphoma model.
Schmitt, C.A. and Wallace-Brodeur, R.R. and Rosenthal, C.T. and McCurrach, M.E. and Lowe, S.W.
Cold Spring Harbor Symposia on Quantitative Biology 65 : 499-510. 1 January 2000

Molecular analysis of the CALM/AF10 fusion: identical rearrangements in acute myeloid leukemia, acute lymphoblastic leukemia and malignant lymphoma patients.
Bohlander, S.K. and Muschinsky, V. and Schrader, K. and Siebert, R. and Schlegelberger, B. and Harder, L. and Schemmel, V. and Fonatsch, C. and Ludwig, W.D. and Hiddemann, W. and Dreyling, M.H.
Leukemia 14 : 93-99. 1 January 2000

Role of crown-like side chains in the biological activity of substituted-phenoxazone drugs.
Karawajew, L. and Glibin, E.N. and Maleev, V.Y. and Czerwony, G. and Doerken, B. and Davies, D.B. and Veselkov, A.N.
Anti-Cancer Drug Design 15 : 331-338. 1 January 2000

Therapy of head and neck squamous cell carcinoma with an oncolytic adenovirus expressing HSV-tk.
Morris, J.C. and Wildner, O.
Molecular Therapy 1 : 56-62. 1 January 2000

1999

Clinical significance of CD95, Bcl-2 and Bax expression and CD95 function in adult de novo acute myeloid leukemia in context of P-glycoprotein function, maturation stage, and cytogenetics.
Wuchter, C. and Karawajew, L. and Ruppert, V. and Buechner, T. and Schoch, C. and Hafelach, T. and Ratei, R. and Doerken, B. and Ludwig, W.D.
Leukemia 13 : 1943-1953. 1 December 1999

Netzplantechnik zur Zeitplanung bei abdominellen Ultraschalluntersuchungen [Project graph technique for time management in abdominal ultrasound evaluations].
Teichgraeber, U.K.M. and Benter, T. and Kluehs, L. and Schroeder, R.J. and Hidajat, N. and Doerken, B. and Felix, R.
Ultraschall in der Medizin 20 : 236-241. 1 December 1999

Improved treatment results in childhood B-cell neoplasms with tailored intensification of therapy: a report of the Berlin-Frankfurt-Muenster group trial NHL-BFM 90.
Reiter, A. and Schrappe, M. and Tiemann, M. and Ludwig, W.D. and Yakisan, E. and Zimmermann, M. and Mann, G. and Chott, A. and Ebell, W. and Klingebiel, T. and Graf, N. and Kremens, B. and Mueller-Weihrich, S. and Pluess, H.J. and Zintl, F. and Henze, G. and Riehm, H.
Blood 94 : 3294-3306. 15 November 1999

Cytokine response gene 6 induces p21 and regulates both cell growth and arrest.
Fan, W. and Richter, G. and Cereseto, A. and Beadling, C. and Smith, K.A.
Oncogene 18 : 6573-6582. 11 November 1999

Impact of immunophenotyping on management of acute leukemias.
Bene, M.C. and Bernier, M. and Castoldi, G. and Faure, G.C. and Knapp, W. and Ludwig, W.D. and Matutes, E. and Orfao, A. and van't Veer, M.
Haematologica 84 : 1024-1034. 1 November 1999

Overexpression of IkappaBalpha without inhibition of NF-kappaB activity and mutations in the IkappaBalpha gene in Reed-Sternberg cells.
Emmerich, F. and Meiser, M. and Hummel, M. and Demel, G. and Foss, H.D. and Jundt, F. and Mathas, S. and Krappmann, D. and Scheidereit, C. and Stein, H. and Doerken, B.
Blood 94 : 3129-3134. 1 November 1999

INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53.
Schmitt, C.A. and McCurrach, M.E. and de Stanchina, E. and Wallace-Brodeur, R.R. and Lowe, S.W.
Genes & Development 13 (20): 2670-2677. 15 October 1999

Intracellular expression of CD61 precedes surface expression.
Kaefer, G. and Willer, A. and Ludwig, W.D. and Kraemer, A. and Hehlmann, R. and Hastka, J.
Annals of Hematology 78 : 472-474. 1 October 1999

Percutaneous central venous catheterization with a lethal complication.
Benter, T. and Teichgraeber, U.K.M. and Kluehs, L. and Doerken, B.
Intensive Care Medicine 25 : 1180-1182. 1 October 1999

A role for beta2 integrins (CD11/CD18) in the regulation of cytokine gene expression of polymorphonuclear neutrophils during the inflammatory response.
Walzog, B. and Weinmann, P. and Jeblonski, F. and Scharffetter-Kochanek, K. and Bommert, K. and Gaehtgens, P.
FASEB Journal 13 (13): 1855-1865. October 1999

Hodgkin/Reed-Sternberg cells induce fibroblasts to secrete eotaxin, a potent chemoattractant for T cells and eosinophils.
Jundt, F. and Anagnostopoulos, I. and Bommert, K. and Emmerich, F. and Mueller, G. and Foss, H.D. and Royer, H.D. and Stein, H. and Doerken, B.
Blood 94 : 2065-2071. 15 September 1999

CD95/Fas-triggered apoptosis of activated T lymphocytes is prevented by dendritic cells through a CD58-dependent mechanism.
Daniel, P.T. and Scholz, C. and Essmann, F. and Westermann, J. and Pezzutto, A. and Doerken, B.
Experimental Hematology 27 : 1402-1408. 1 September 1999

Prednisone response is the strongest predictor of treatment outcome in infant acute lymphoblastic leukemia.
Doerdelmann, M. and Reiter, A. and Borkhardt, A. and Ludwig, W.D. and Goetz, N. and Viehmann, S. and Gadner, H. and Riehm, H. and Schrappe, M.
Blood 94 (4): 1209-1217. 15 August 1999

Expression of the death gene Bik/Nbk promotes sensitivity to drug-induced apoptosis in corticosteroid-resistant T-cell lymphoma and prevents tumor growth in severe combined immunodeficient mice.
Daniel, P.T. and Pun, K.T. and Ritschel, S. and Sturm, I. and Holler, J. and Doerken, B. and Brown, R.
Blood 94 : 1100-1107. 1 August 1999

Interventional antimicrobial therapy in febrile neutropenic patients.
Maschmeyer, G.
Diagnostic Microbiology and Infectous Disease 34 : 205-212. 1 July 1999

Double induction strategy for acute myeloid leukemia: the effect of high-dose cytarabine with mitoxantrone instead of standard-dose cytarabine with daunorubicin and 6-thioguanine: a randomized trial by the german AML cooperative group.
Buechner, T. and Hiddemann, W. and Woermann, B. and Loeffler, H. and Gassmann, W. and Haferlach, T. and Fonatsch, C. and Haase, D. and Schoch, C. and Hossfeld, D. and Lengfelder, E. and Aul, C. and Heyll, A. and Maschmeyer, G. and Ludwig, W.D. and Sauerland, M.C. and Heinecke, A.
Blood 93 : 4116-4124. 15 June 1999

Aerosolized amphotericin B inhalations as prophylaxis of invasive aspergillus infections during prolonged neutropenia: results of a prospective randomized multicenter trial.
Schwartz, S. and Behre, G. and Heinemann, V. and Wandt, H. and Schilling, E. and Arning, M. and Trittin, A. and Kern, W.V. and Boenisch, O. and Bosse, D. and Lenz, K. and Ludwig, W.D. and Hiddemann, W. and Siegert, W. and Beyer, J.
Blood 93 (11): 3654-3661. 1 June 1999

Expression of the C-kit receptor (CD117) is a feature of almost all subtypes of de novo acute myeloblastic leukemia (AML), including cytogenetically good-risk AML, and lacks prognostic significance.
Schwartz, S. and Heinecke, A. and Zimmermann, M. and Creutzig, U. and Schoch, C. and Harbott, J. and Fonatsch, C. and Loeffler, H. and Buechner, T. and Ludwig, W.D. and Thiel, E.
Leukemia & Lymphoma 34 (1-2): 85-94. June 1999

Analysis of the p53/BAX pathway in colorectal cancer: low BAX is a negative prognostic factor in patients with resected liver metastases.
Sturm, I. and Koehne, C.H. and Wolff, G. and Petrowsky, H. and Hillebrand, T. and Hauptmann, S. and Lorenz, M. and Doerken, B. and Daniel, P.T.
Journal of Clinical Oncology 17 : 1364-1374. 1 May 1999

Combined positive/ negative selection in stem cell transplantation: perspectives in graft engineering.
Mapara, M.Y. and Koerner, I.J. and Lentzsch, S. and Hildebrandt, M. and Doerken, B.
Infusionstherapie und Transfusionsmedizin 26 : 140-145. 1 May 1999

Brain metastases in breast cancer: prognostic factors and management.
Lentzsch, S. and Reichardt, P. and Weber, F. and Budach, V. and Doerken, B.
European Journal of Cancer 35 : 580-585. 1 April 1999

Regulators of G protein signaling exhibit distinct patterns of gene expression and target G protein specificity in human lymphocytes.
Beadling, C. and Druey, K.M. and Richter, G. and Kehrl, J.H. and Smith, K.A.
Journal of Immunology 162 : 2677-2682. 1 March 1999

Staging and monitoring of malignant lymphoma of the bone: comparison of 67Ga scintigraphy and MRI.
Stroszczynski, C. and Oellinger, J. and Hosten, N. and Spahn, G. and Amthauer, H. and Ricke, J. and Hoffmann, K.T. and Eichstaedt, H. and Ludwig, W.D. and Felix, R.
Journal of Nuclear Medicine 40 : 387-393. 1 March 1999

Identifikation molekularer Regulatoren der anti-IgM induzierten B-Zell Apoptose.
Rickers, A.
UNSPECIFIED thesis, UNSPECIFIED. 16 February 1999

European surveillance of infections and risk factors in cancer patients.
Buchheidt, D. and Hiddemann, W. and Schiel, X. and Kremery, V. and Karthaus, M. and Donnelly, J.P. and Wilhelm, M. and Maschmeyer, G. and Link, H. and Adam, D. and Helmerking, M.
European journal of clinical microbiology & infectious diseases 18 : 161-163. 1 February 1999

Immunophenotypic and immunogenotypic characteristics of TCR gammadelta+ T cell acute lymphoblastic leukemia.
Langerak, A.W. and Wolvers-Tettero, I.L. and van den Beemd, M.W.M. and van Wering, E.R. and Ludwig, W.D. and Haehlen, K. and Necker, A. and van Dongen, J.J.M.
Leukemia 13 : 206-214. 1 February 1999

Study of Burkitt lymphoma cell line proteins by high resolution two-dimensional gel electrophoresis and nanoelectrospray mass spectrometry.
Mueller, E.C. and Schuemann, M. and Rickers, A. and Bommert, K. and Wittmann-Liebold, B. and Otto, A.
Electrophoresis 20 : 320-330. 1 February 1999

Preparative high-resolution two-dimensional electrophoresis enables the identification of RNA polymerase B transcription factor 3 as an apoptosis-associated protein in the human BL60-2 Burkitt lymphoma cell line.
Brockstedt, E. and Otto, A. and Rickers, A. and Bommert, K. and Wittmann-Liebold, B.
Journal of Protein Chemistry 18 (2): 225-231. February 1999

Molecular mechanisms of constitutive NF-kappaB/Rel activation in Hodgkin/Reed-Sternberg cells.
Krappmann, D. and Emmerich, F. and Kordes, U. and Scharschmidt, E. and Doerken, B. and Scheidereit, C.
Oncogene 18 : 943-953. 28 January 1999

Results of surgery and multimodal therapy for patients with soft tissue sarcoma invading to vascular structures.
Hohenberger, P. and Allenberg, J.R. and Schlag, P.M. and Reichardt, P.
Cancer 85 : 396-408. 15 January 1999

Analysis of the p53/BAX pathway: Low BAX expression is a negative prognostic factor in patients with resected liver metastases of colorectal adenocarcinoma.
Daniel, P.T. and Sturm, I. and Wolff, G. and Petrowsky, H. and Koehne, C.H. and Hillebrand, T. and Doerken, B. and Lorenz, M.
Langenbecks Archiv fuer Chirurgie Suppl. 1 : 163-169. 1 January 1999

Apoptosis and therapy.
Schmitt, C.A. and Lowe, S.W.
Journal of Pathology 187 : 127-137. 1 January 1999

Cleavage of transcription factor SP1 by caspases during anti-IgM-induced B-cell apoptosis.
Rickers, A. and Peters, N. and Badock, V. and Beyaert, R. and Vandenabeele, P. and Doerken, B. and Bommert, K.
European Journal of Biochemistry 261 : 269-274. 1 January 1999

Combined positive/negative purging and transplantation of peripheral blood progenitor cell autografts in breast cancer patients: a pilot study.
Mapara, M.Y. and Koerner, I.J. and Lentzsch, S. and Krahl, D. and Reichardt, P. and Doerken, B.
Experimental Hematology 27 : 169-175. 1 January 1999

Detection of genomic DNA fragmentation during apoptosis (DNA ladder) and the simultaneous isolation of RNA from low cell numbers.
Daniel, P.T. and Sturm, I. and Ritschel, S. and Friedrich, K. and Doerken, B. and Bendzko, P. and Hillebrand, T.
Analytical Biochemistry 266 : 110-115. 1 January 1999

Direct and indirect T cell priming by dendritic cell vaccines.
Cayeux, S. and Richter, G. and Becker, C. and Pezzutto, A. and Doerken, B. and Blankenstein, T.
European Journal of Immunology 29 : 225-234. 1 January 1999

Expression and regulation by interferon-gamma of the membrane-bound complement regulators CD46 (MCP), CD55 (DAF) and CD59 in gastrointestinal tumours.
Schmitt, C.A. and Schwaeble, W. and Wittig, B.M. and Meyer Zum Bueschenfelde, K.H. and Dippold, W.G.
European Journal of Cancer 35 : 117-124. 1 January 1999

Humoral immunotherapy and the use of monoclonal antibodies.
Daniel, P.T. and Pezzutto, A. and Doerken, B.
In: Textbook of Malignant Haematology. Martin Dunitz Ltd., London, 425-446. 1 January 1999

Vaccines using gene-modified tumor cells.
Cayeux, S. and Qin, Z. and Doerken, B. and Blankenstein, T.
In: Gene therapy :Principles and Applications. Birkhaeuser, Basel, 283-298. ISBN 3-7643-5972-2 1 January 1999

1998

Immunotherapy of B-cell lymphoma with CD3x19 bispecific antibodies: costimulation via CD28 prevents "Veto" apoptosis of antibody-targeted cytotoxic T cells.
Daniel, P.T. and Kroidl, A. and Kopp, J. and Sturm, I. and Moldenhauer, G. and Doerken, B. and Pezzutto, A.
Blood 92 (12): 4750-4757. 15 December 1998

Antibodies TC-12 ("unique") and TH-111 (CD96) characterize T-cell acute lymphoblastic leukemia and a subgroup of acute myeloid leukemia.
Gramatzki, M. and Ludwig, W.D. and Burger, R. and Moos, P. and Rohwer, P. and Grunert, C. and Sendler, A. and Kalden, J.R. and Andreesen, R. and Henschke, F. and Moldenhauer, G.
Experimental Hematology 26 : 1209-1214. 1 December 1998

The effect of hexadecylphosphocholine on the proliferation of human keratinocytes in vitro and in vivo.
Wieder, T. and Reutter, W. and Orfanos, C.E. and Geilen, C.C.
Drugs of Today 34 Suppl. F : 97-105. 1 December 1998

Prognostic value of minimal residual disease in acute lymphoblastic leukaemia in childhood.
van Dongen, J.J. and Seriu, T. and Panzer-Gruemayer, E.R. and Biondi, A. and Pongers-Willemse, M.J. and Corral, L. and Stolz, F. and Schrappe, M. and Masera, G. and Kamps, W.A. and Gadner, H. and van Wering, E.R. and Ludwig, W.D. and Basso, G. and de Bruijn, M.A. and Cazzaniga, G. and Hettinger, K. and van der Does-van den Berg, A. and Hop, W.C. and Riehm, H. and Bartram, C.R.
Lancet 352 (9142): 1731-1738. 28 November 1998

Growth and differentiation of human stem cell factor/erythropoietin-dependent erythroid progenitor cells in vitro.
Panzenboeck, B. and Bartunek, P. and Mapara, M.Y. and Zenke, M.
Blood 92 (10): 3658-3668. 15 November 1998

Retrovirales Vektorsystem zur Optimierung des Gentransfers und der Genexpression in primaeren humanen T-Lymphozyten.
Schroeder, A. and Schwenkenbecher, J.M. and Bargou, R.
DE19720152A1. 5 November 1998

Spiral-CT. Besseres Aufloesungsvermoegen durch groesseren Pitch?
Rockstroh, G.
Aktuelle Radiologie 8 : 250-252. 1 November 1998

Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line - cleavage of heterogeneous nuclear ribonucleoprotein A1 by caspase 3.
Brockstedt, E. and Rickers, A. and Kostka, S. and Laubersheimer, A. and Doerken, B. and Wittmann-Liebold, B. and Bommert, K. and Otto, A.
Journal of Biological Chemistry 273 (43): 28057-28064. 23 October 1998

Detection of tumor cells in peripheral blood samples from patients with germ cell tumors using immunocytochemical and reverse transcriptase-polymerase chain reaction techniques.
Hildebrandt, M. and Blaser, F. and Beyer, J. and Siegert, W. and Mapara, M.Y. and Huhn, D. and Salama, A.
Bone Marrow Transplantation 22 : 771-775. 1 October 1998

Immunophenotypic and genotypic features, clinical characteristics, and treatment outcome of adult pro-B acute lymphoblastic leukemia: Results of the German multicenter trials GMALL 03/87 and 04/89.
Ludwig, W.D. and Rieder, H. and Bartram, C.R. and Heinze, B. and Schwartz, S. and Gassmann, W. and Loeffler, H. and Hossfeld, D. and Heil, G. and Handt, S. and Heyll, A. and Diedrich, H. and Fischer, K. and Weiss, A. and Voelkers, B. and Aydemir, U. and Fonatsch, C. and Goekbuget, N. and Thiel, E. and Hoelzer, D.
Blood 92 (6): 1898-1909. 15 September 1998

Granulocyte colony-stimulating factor shortens duration of critical neutropenia and prolongs disease-free survival after sequential high-dose cytosine arabinoside and mitoxantrone (S-HAM) salvage therapy for refractory and relapsed acute myeloid leukemia.
Kern, W. and Aul, C. and Maschmeyer, G. and Kuse, R. and Kerkhoff, A. and Grote-Metke, A. and Eimermacher, H. and Kubica, U. and Woermann, B. and Buechner, T. and Hiddemann, W.
Annals of Hematology 77 : 115-122. 1 September 1998

High rate of chromosome abnormalities detected by fluorescence in situ hybridization using BCR and ABL probes in adult acute lymphoblastic leukemia.
Rieder, H. and Bonwetsch, C. and Janssen, L.A.J. and Maurer, J. and Janssen, J.W.G. and Schwartz, S. and Ludwig, W.D. and Gassmann, W. and Bartram, C.R. and Thiel, E. and Loeffler, H. and Gokbuget, N. and Hoelzer, D. and Fonatsch, C.
Leukemia 12 : 1473-1481. 1 September 1998

Immunophenotype and clinical characteristics of CD45-negative and CD45-positive childhood acute lymphoblastic leukemia.
Ratei, R. and Sperling, C. and Karawajew, L. and Schott, G. and Schrappe, M. and Harbott, J. and Riehm, H. and Ludwig, W.D.
Annals of Hematology 77 : 107-114. 1 September 1998

Loss of laminin and of the laminin receptor integrin subunit � in situ correlates with cytokine induced down regulation of alpha 6 on fibroblast-like synoviocytes from rheumatoid arthritis.
Rinaldi, N. and Barth, T.F. and Weis, D. and Schwarz-Eywill, M. and Pezzutto, A. and Lukoschek, M. and Brocai, D. and Brado, B.
Annals of the Rheumatic Diseases 57 : 559-565. 1 September 1998

Sequence analysis of the first HTLV-I infection in Germany without relations to endemic areas-short communication.
Ellerbrok, H. and Fleischer, C. and Salemi, M. and Reinhardt, P. and Ludwig, W.D. and Vandamme, A.M. and Pauli, G.
AIDS Research and Human Retroviruses 14 : 1199-1203. 1 September 1998

Expression and regulation of c-kit receptor and response to stem cell factor in childhood malignant T-lymphoblastic cells.
Tomeczkowski, J. and Frick, D. and Schwinzer, B. and Wittner, N. and Ludwig, W.D. and Reiter, A. and Welte, K. and Sykora, K.W.
Leukemia 12 : 1221-1229. 1 August 1998

High performance two dimensional gel electrophoresis and nanoelectrospray mass spectrometry as powerful tool to study apoptosis-associated processes in a Burkitt lymphoma cell line.
Otto, A. and Mueller, E.C. and Brockstedt, E. and Schumann, M. and Rickers, A. and Bommert, K. and Wittmann-Liebold, B.
Journal of Protein Chemistry 17 : 564-565. 1 August 1998

Mutation analysis of CD95 (APO-1/Fas) in childhood B-lineage acute lymphoblastic leukaemia.
Beltinger, C. and Boehler, T. and Karawajew, L. and Ludwig, W.D. and Schrappe, M. and Debatin, K.M.
British Journal of Haematology 102 : 722-728. 1 August 1998

The reliability and specificity of c-kit for the diagnosis of acute myeloid leukemias and undifferentiated leukemias.
Bene, M.C. and Bernier, M. and Casasnovas, R.O. and Castoldi, G. and Knapp, W. and Lanza, F. and Ludwig, W.D. and Matutes, E. and Orfao, A. and Sperling, C. and van't Veer, M.B.
Blood 92 (2): 596-599. 15 July 1998

Superiority of high-dose over intermediate-dose cytosine arabinoside in the treatment of patients with high-risk acute myeloid leukemia: results of an age-adjusted prospective randomized comparison.
Kern, W. and Aul, C. and Maschmeyer, G. and Schoenrock-Nabulsi, R. and Ludwig, W.D. and Bartholomaeus, A. and Bettelheim, P. and Woermann, B. and Buechner, T. and Hiddemann, W.
Leukemia 12 : 1049-1055. 1 July 1998

MLL and CALM are fused to AF10 in morphologically distinct subsets of acute leukemia with translocation t(10;11): both rearrangements are associated with a poor prognosis.
Dreyling, M.H. and Schrader, K. and Fonatsch, C. and Schlegelberger, B. and Haase, D. and Schoch, C. and Ludwig, W.D. and Loeffler, H. and Buechner, T. and Wormann, B. and Hiddemann, W. and Bohlander, S.K.
Blood 91 (12): 4662-4667. 15 June 1998

CD95 (APO-1/Fas) mutations in childhood T-lineage acute lymphoblastic leukemia.
Beltinger, C. and Kurz, E. and Boehler, T. and Schrappe, M. and Ludwig, W.D. and Debatin, K.M.
Blood 91 (10): 3943-3951. 15 May 1998

Down's syndrome in childhood acute lymphoblastic leukemia: clinical characteristics and treatment outcome in four consecutive BFM trials.
Dordelmann, M. and Schrappe, M. and Reiter, A. and Zimmermann, M. and Graf, N. and Schott, G. and Lampert, F. and Harbott, J. and Niemeyer, C. and Ritter, J. and Dorffel, W. and Nessler, G. and Kuhl, J. and Riehm, H.
Leukemia 12 : 645-651. 1 May 1998

Induction of ceramide-mediated apoptosis by the anticancer pPhospholipid analog, hexadecylphosphocholine.
Wieder, T. and Orfanos, C.E. and Geilen, C.C.
Journal of Biological Chemistry 273 (18): 11025-11031. 1 May 1998

Dose-intensive chemotherapy with ifosfamide, epirubicin, and filgrastim for adult patients with metastatic or locally advanced soft tissue sarcoma: A phase II study.
Reichardt, P. and Tilgner, J. and Hohenberger, P. and Doerken, B.
Journal of Clinical Oncology 16 (4): 1438-1443. April 1998

Expression and regulation of phospholipase D in the human keratinocyte cell line HaCaT.
Mueller-Wieprecht, V. and Riebeling, C. and Alexander, C. and Scholz, F.R. and Hoeer, A. and Wieder, T. and Orfanos, C.E. and Geilen, C.C.
FEBS Letters 425 : 199-203. 27 March 1998

Correlation of cytogenetic, molecular cytogenetic, and clinical findings in 59 patients with ANLL or MDS and abnormalities of the short arm of chromosome 12.
Streubel, B. and Sauerland, C. and Heil, G. and Freund, M. and Bartels, H. and Lengfelder, E. and Wandt, H. and Ludwig, W.D. and Nowotny, H. and Baldus, M. and Grothaus-Pinke, B. and Buechner, T. and Fonatsch, C.
British Journal of Haematology 100 : 521-533. 1 March 1998

Detection of hyperdiploid karyotypes (>50 chromosomes) in childhood acute lymphoblastic leukemia (ALL) using fluorescence in situ hybridization (FISH).
Ritterbach, J. and Hiddemann, W. and Beck, J.D. and Schrappe, M. and Janka-Schaub, G. and Ludwig, W.D. and Harbott, J. and Lampert, F.
Leukemia 12 : 427-433. 1 March 1998

A glucose-containing ether lipid (Glc-PAF) as an antiproliferative analogue of the platelet-activating factor.
Mickeleit, M. and Wieder, T. and Arnold, M. and Geilen, C.C. and Mulzer, J. and Reutter, W.
Angewandte Chemie International Edition 37 (3): 351-353. 16 February 1998

Detection of the DCC gene product in normal and malignant colorectal tissues and its relation to a codon 201 mutation.
Schmitt, C.A. and Thaler, K.R. and Wittig, B.M. and Kaulen, H. and Meyer Zum Bueschenfelde, K.H. and Dippold, W.G.
British Journal of Cancer 77 : 588-594. 1 February 1998

Expansion of autoreactive T cells in multiple sclerosis is independent of exogenous B7 costimulation.
Scholz, C. and Patton, K.T. and Anderson, D.E. and Freeman, G.J. and Hafler, D.A.
Journal of Immunology 160 (3): 1532-1538. 1 February 1998

Meropenem monotherapy versus combination therapy with ceftazidime and amikacin for empirical treatment of febrile neutropenic patients.
Behre, G. and Link, H. and Maschmeyer, G. and Meyer, P. and Paaz, U. and Wilhelm, M. and Hiddemann, W.
Annals of Hematology 76 : 73-80. 1 February 1998

Effective biomodulation by leucovorin of high-dose infusion fluorouracil given as a weekly 24-hour infusion: results of a randomized trial in patients with advanced colorectal cancer.
Koehne, C.H. and Schoeffski, P. and Wilke, H. and Kaeufer, C. and Andreesen, R. and Ohl, U. and Klaasen, U. and Westerhausen, M. and Hiddemann, W. and Schott, G. and Harstick, A. and Bade, J. and Horster, A. and Schubert, U. and Hecker, H. and Doerken, B. and Schmoll, H.J.
Journal of Clinical Oncology 16 (2): 418-426. February 1998

A pilot study on intensive weekly 24-hour intra-arterial infusion with 5-fluorouracil and folinic acid for colorectal liver metastases.
Lorenz, M. and Staib-Sebler, E. and Gog, C. and Petrowsky, H. and Koehne, C.H. and Encke, A.
Oncology 55 : 53-58. 1 January 1998

Dendritic cells for somatic gene therapy.
Westermann, J. and Aicher, A. and Pezzutto, A.
Recent Results in Cancer Research 144 : 70-77. 1 January 1998

Dendritic cells prevent CD95 mediated T lymphocyte death through costimulatory signals.
Daniel, P.T. and Scholz, C. and Westermann, J. and Doerken, B. and Pezzutto, A.
Advances in Experimental Medicine and Biology 451 : 173-177. 1 January 1998

Ex vivo breast cancer cell purging by adenovirus- mediated cytosine deaminase gene transfer and short-term incubation with 5-Fluorocytosine completely prevents tumor growth after transplantation.
Wolff, G. and Koerner, I. and Schumacher, A. and Arnold, W. and Doerken, B. and Mapara, M.Y.
Human Gene Therapy 9 : 2277-2284. 1 January 1998

Immunophenotypic and clinical features of T-cell receptor gammadelta+ T-lineage acute lymphoblastic leukaemia.
Schott, G. and Sperling, C. and Schrappe, M. and Ratei, R. and Martin, M. and Meyer, U. and Riehm, H. and Ludwig, W.D.
British Journal of Haematology 101 : 753-755. 1 January 1998

Inhibition of CPP32 blocks surface IgM-mediated apoptosis and D4-GDI cleavage in human BL 60 Burkitt lymphoma cells.
Rickers, A. and Brockstedt, E. and Mapara, M.Y. and Otto, A. and Doerken, B. and Bommert, K.
European Journal of Immunology 28 : 296-304. 1 January 1998

Is continuous 24-Hour Infusion of 5-fluorouracil plus high-dose folinic acid effective in patients with progressive or recurrent colorectal cancer? A phase II study.
Hartmann, J.T. and Koehne, C.H. and Schmoll, H.J. and Daikeler, T. and Kanz, L. and Bokemeyer, C.
Oncology 55 : 320-325. 1 January 1998

Retroviral B7.1 gene transfer in cancer cells protects cytotoxic T cells from deletion by "veto" apoptosis.
Daniel, P.T. and Kroidl, A. and Cayeux, S. and Scholz, C. and Sturm, I. and Blankenstein, T. and Pezzutto, A. and Doerken, B.
Advances in Experimental Medicine and Biology 451 : 265-276. 1 January 1998

Retroviral interleukin-7 gene transfer into human dendritic cells enhances T cell activation.
Westermann, J. and Aicher, A. and Qin, Z. and Cayeux, S. and Daemen, K. and Blankenstein, T. and Doerken, B. and Pezzutto, A.
Gene Therapy 5 : 264-271. 1 January 1998

1997

Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells.
Bargou, R.C. and Emmerich, F. and Krappmann, D. and Bommert, K. and Mapara, M.Y. and Arnold, W. and Royer, H.D. and Grinstein, E. and Greiner, A. and Scheidereit, C. and Doerken, B.
Journal of Clinical Investigation 100 (12): 2961-2969. 15 December 1997

Differential expression and functional behaviour of the ഠand ౠintegrin subunits in cytokine stimulated fibroblast-like cells derived from synovial tissue of rheumatoid arthritis and osteoarthritis in vitro.
Rinaldi, N. and Weis, D. and Brado, B. and Schwarz-Eywill, M. and Lukoschek, M. and Pezzutto, A. and Keilholz, U. and Barth, T.F.
Annals of the Rheumatic Diseases 56 : 729-736. 1 December 1997

Expression of a hypoglycosylated form of CD86 (B7-2) on human T cells with altered binding properties to CD28 and CTLA-4.
Hoellsberg, P. and Scholz, C. and Anderson, D.E. and Greenfield, E.A. and Kuchroo, V.K. and Freeman, G.J. and Hafler, D.A.
Journal of Immunology 159 (10): 4799-4805. 15 November 1997

New insights into the biology of Philadelphia-chromosome-positive acute lymphoblastic leukaemia using a combination of May-Grunwald-Giemsa staining and fluorescence in situ hybridization techniques at the single cell level.
Haferlach, T. and Winkemann, M. and Ramm-Petersen, L. and Meeder, M. and Schoch, R. and Weber-Matthiesen, K. and Schlegelberger, B. and Schoch, C. and Ludwig, W.D. and Hiddemann, W. and Loffler, H.
British Journal of Haematology 99 : 452-459. 1 November 1997

Verfahren zum Gentransfer in tierische Zellen.
Boettger, M. and Arnold, W. and Zaitsev, S.V. and Haberland, A.
DE19616645A1. 30 October 1997

Costimulatory signals through B7.1/CD28 prevent T cell apoptosis during target cell lysis.
Daniel, P.T. and Kroidl, A. and Cayeux, S. and Bargou, R.C. and Blankenstein, T. and Doerken, B.
Journal of Immunology 159 (8): 3808-3815. 15 October 1997

Role of alveolar macrophages in rapid elimination of adenovirus vectors administered to the epithelial surface of the respiratory tract.
Worgall, S. and Leopold, P.L. and Wolff, G. and Ferris, B. and Van Roijen, N. and Crystal, R.G.
Human Gene Therapy 8 (14): 1675-1684. 20 September 1997

Modulation of 5-fluorouracil with methotrexate and low-dose N-(phosphonacetyl)-L-aspartate (PALA) is inactive in advanced pancreatic carcinoma.
Harstrick, A. and Kohne, C.H. and Hiddemann, W. and Preusser, P. and Strumberg, D. and Berns, T. and Seeber, S. and Wilke, H. and Schmoll, H.J.
Annals of Oncology 8 : 917-918. 1 September 1997

Retroviraler Vektor fuer den Gentransfer eines IL6-Antagonisten in humane haematopoetische Stammzellen.
Bargou, R. and Baum, C. and Hoenemann, D.
DE19704979A1. 14 August 1997

Role of cranial radiotherapy for childhood T-cell acute lymphobalstic leukemia with high WBC count and good response to prednisone.
Conter, V. and Schrappe, M. and Arico, M. and Reiter, A. and Rizzari, C. and Doerdelmann, M. and Valsecchi, M.G. and Zimmermann, M. and Ludwig, W.D. and Basso, G. and Masera, G. and Riehm, H.
Journal of Clinical Oncology 15 (8): 2786-2791. August 1997

Lebendvakzine zur Behandlung von Tumorerkrankungen [Live vaccine for the treatment of tumour diseases].
T. Blankenstein, S. Cayeux.
EP0777499A1 ; EP0777499B1 ; WO9605866A2 ; WO9605866A3 ; US6,039,941. 11 June 1997

Treatment of brain metastases in patients with testicular cancer.
Bokemeyer, C. and Nowak, P. and Haupt, A. and Metzner, B. and Koehne, H. and Hartmann, J.T. and Kanz, L. and Schmoll, H.J.
Journal of Clinical Oncology 15 (4): 1449-1454. April 1997

Activation and activation-induced death of human tonsillar B cells and Burkitt lymphoma cells: lack of CD95 (Fas/APO-1) ligand expression and function.
Daniel, P.T. and Oettinger, U. and Mapara, M.Y. and Bommert, K. and Bargou, R.C. and Doerken, B.
European Journal of Immunology 27 : 1029-1034. 1 January 1997

Antimikrobielle Therapie bei Neutropenie.
Maschmeyer, G. and Vogt, K. and Hahn, H. and Doerken, B.
Deutsche Medizinische Wochenschrift 122 : 864-869. 1 January 1997

Differential CD95 expression and function in T and B lineage acute lymphoblastic leukemia cells.
Karawajew, L. and Wuchter, C. and Ruppert, V. and Drexler, H. and Gruss, H.J. and Doerken, B. and Ludwig, W.D.
Leukemia 11 : 1245-1252. 1 January 1997

Enhancement of in vivo adenovirus-mediated gene transfer and expression by prior depletion of tissue macrophages in the target organ.
Wolff, G. and Worgall, S. and van Rooijen, N. and Song, W.R. and Harvey, B.G. and Crystal, R.G.
Journal of Virology 71 (1): 624-629. 1 January 1997

Expression of intercellular adhesion molecule 1 (ICAM-1) in childhood acute lymphoblastic leukemia: correlation with clinical features and outcome.
Mielcarek, M. and Sperling, C. and Schrappe, M. and Meyer, U. and Riehm, H. and Ludwig, W.D.
British Journal of Haematology 96 : 301-307. 1 January 1997

Expression of the stem cell factor receptor c-kit (CD117) in acute leukemias.
Sperling, C. and Schwartz, S. and Buechner, T. and Thiel, E. and Ludwig, W.D.
Haematologica 82 : 617-621. 1 January 1997

Incidence and clinical relevance of TEL/AML1 fusion genes in children with acute lymphoblastic leukemia enrolled in the german and italian multicenter therapy trials.
Borkhardt, A. and Cazzaniga, G. and Viehmann, S. and Valsecchi, M.G. and Ludwig, W.D. and Burci, L. and Mangioni, S. and Schrappe, M. and Riehm, H. and Lampert, F. and Basso, G. and Masera, G. and Harbott, J. and Biondi, A.
Blood 90 : 571-577. 1 January 1997

Influence of gene modified (IL 7, IL 4, and B7) tumor cell vaccines on tumor antigen presentation.
Cayeux, S. and Richter, G. and Noffz, G. and Doerken, B. and Blankenstein, T.
Journal of Immunology 158 : 2834-2841. 1 January 1997

Innate immune mechanisms dominate elimination of adenoviral vectors following in vivo administration.
Worgall, S. and Wolff, G. and Falck-Pedersen, E. and Crystal, R.G.
Human Gene Therapy 8 : 37-44. 1 January 1997

Lack of correlation between rejection of tumor cells co-expressing interleukin 2 and B7.1 and vaccine efficiency.
Cayeux, S. and Richter, G. and Becker, C. and Beck, C. and Aicher, A. and Pezzutto, A. and Doerken, B. and Blankenstein, T.
European Journal of Immunology 27 : 1657-1662. 1 January 1997

Liver associated toxicity of the hsv tk/gcv approach and adenoviral vectors.
Brand, K. and Arnold, W. and Bartels, T. and Lieber, A. and Kay, M.A. and Strauss, M. and Doerken, B.
Cancer Gene Therapy 4 (1): 9-16. 1 January 1997

Modulation of 5-fluorouracil with methotrexate and low-dose N- (phosphonacetyl)-L-aspartate in patients with advanced colorectal cancer. results of a phase II study.
Koehne, C.H. and Harstrick, A. and Hiddemann, W. and Schoeffski, P. and Wilke, H. and Bokemeyer, C. and Doerken, B. and Schmoll, H.J.
European Journal of Cancer 33 : 1896-1899. 1 January 1997

Monitoring of tumor cell purging after highly efficient immunomagnetic selection of CD34 cells from leukapheresis products in breast cancer patients: comparision of immunocytochemical tumor cells staining and RT-PCR.
Mapara, M.Y. and Koerner, I.J. and Hildebrandt, M. and Bargou, R.C. and Krahl, D. and Reichardt, P. and Doerken, B.
Blood 89 (1): 337-344. 1 January 1997

Morphological and cytochemical findings in 150 cases of T-lineage acute lymphoblastic leukemia in adults.
Gassmann, W. and Loeffler, H. and Thiel, E. and Ludwig, W.D. and Schwartz, S. and Haferlach, T. and Maurer, J. and Rieder, H. and Fonatsch, C. and Goekbuget, N. and Hoelzer, D.
British Journal of Haematology 97 : 372-382. 1 January 1997

Nuclear localization and increased levels of transcription factor YB-1 in primary human breast cancers are associated with intrinsic MDR1 gene expression.
Bargou, R.C. and Juerchott, K. and Wagener, C. and Bergmann, S. and Metzner, S. and Bommert, K. and Mapara, M.Y. and Winzer, K.J. and Dietel, M. and Doerken, B. and Royer, H.D.
Nature Medicine 3 : 447-450. 1 January 1997

Overexpression of the death-promoting gene bax-alpha sensitizes human BL-41 Burkitt lymphoma cells for surface IgM-mediated apoptosis.
Weinmann, P. and Bommert, K. and Mapara, M.Y. and Doerken, B. and Bargou, R.C.
European Journal of Immunology 27 : 2466-2468. 1 January 1997

Prognostic significance of additional chromosome abnormalities in adult patients with philadelphia chromosome positive acute lymphoblastic leukaemia.
Rieder, H. and Ludwig, W.D. and Gassmann, W. and Maurer, J. and Janssen, J.W. and Gokbuget, N. and Schwartz, S. and Thiel, E. and Loeffler, H. and Bartram, C.R. and Hoelzer, D. and Fonatsch, C.
British Journal of Haematology 95 : 678-691. 1 January 1997

Reverse transcriptase-polymerase chain reaction (RT-PCR)-controlled immunomagnetic purging of breast cancer cells using the magnetic cell separation (MACS) system: a sensitive method for monitoring purging efficiency.
Hildebrandt, M. and Mapara, M.Y. and Koerner, I.J. and Bargou, R.C. and Moldenhauer, G. and Doerken, B.
Experimental Hematology 25 : 57-65. 1 January 1997

Successful retroviral mediated transduction of a receptor gene in human dendritic cells: feasibility of therapy with gene-modified antigen presenting cells.
Aicher, A. and Westermann, J. and Cayeux, S. and Willimsky, G. and Daemen, K. and Blankenstein, T. and Uckert, W. and Doerken, B. and Pezzutto, A.
Experimental Hematology 25 : 39-44. 1 January 1997

The value of weekly high dose infusional 5-fluorouracil in the treatment of advanced colorectal cancer.
Koehne, C.H. and Daniel, P.T. and Doerken, B.
Tumori 83, 1 : S56-S60. 1 January 1997

Tumor cell vaccines using genetically modified cells coexpressing cytokines and the T cell costimulatory molecule B7.
Cayeux, S. and Doerken, B. and Blankenstein, T.
In: Concepts in Gene Therapy. de Gruyter, Berlin [u.a.], 487-503. 1 January 1997

1996

Myelodysplasia and acute myelogenous leukemia in Down's syndrome. A report of 40 children of the AML-BFM Study Group.
Creutzig, U. and Ritter, J. and Vormoor, J. and Ludwig, W.D. and Niemeyer, C. and Reinisch, I. and Stollmann-Gibbels, B. and Zimmermann, M. and Harbott, J.
Leukemia 10 (11): 1677-1686. 1 November 1996

Clinical experiences with magnetic drug targeting: a phase I study with 4'-epidoxorubicin in 14 patients with advanced solid tumors.
Luebbe, A.S. and Bergemann, C. and Riess, H. and Schriever, F. and Reichardt, P. and Possinger, K. and Matthias, M. and Doerken, B. and Herrmann, F. and Guertler, R. and Hohenberger, P. and Haas, N. and Sohr, R. and Sander, B. and Lemke, A.J. and Ohlendorf, D. and Huhnt, W. and Huhn, D.
Cancer Research 56 (20): 4686-4693. 15 October 1996

Activation of human T cell lymphotropic virus type I-infected T cells is independent of B7 costimulation.
Scholz, C. and Freeman, G.J. and Greenfield, E.A. and Hafler, D.A. and Hollsberg, P.
Journal of Immunology 157 (7): 2932-2938. 1 October 1996

Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in epstein-barr virus (EBV)-related lymphoma cell lines.
Weber-Nordt, R.M. and Egen, C. and Wehinger, J. and Ludwig, W.D. and Gouilleuxgruart, V. and Mertelsmann, R. and Finke, J.
Blood 88 (3): 809-816. 1 August 1996

Induction of the death-promoting gene bax-alpha sensitizes cultured breast-cancer cells to drug-induced apoptosis.
Wagener, C. and Bargou, R.C. and Daniel, P.T. and Bommert, K. and Mapara, M.Y. and Royer, H.D. and Doerken, B.
International Journal of Cancer 67 (1): 138-141. 3 July 1996

Monoclonal antibody WGM1 directed against proteinase 3: an immunohistochemical marker for naphthol ASD chloroacetate.
Braun, M.G. and Csernok, E. and Roegener-Schwarz, W. and Ludwig, W.D. and Mueller-Hermelink, H.K. and Gross, W.L. and Feller, A.C.
Hematological Oncology 14 : 83-90. 1 June 1996

Overexpression of the death-promoting gene bax-alpha which is downregulated in breast cancer restores sensitivity to different apoptotic stimuli and reduces tumor growth in SCID mice.
Bargou, R.C. and Wagener, C. and Bommert, K. and Mapara, M.Y. and Daniel, P.T. and Arnold, W. and Dietel, M. and Guski, H. and Feller, A. and Royer, H.D. and Doerken, B.
Journal of Clinical Investigation 97 (11): 2651-2659. 1 June 1996

Blocking of transcription factor E2F/DP by dominant-negative mutants in a normal breast epithelial cell line efficiently inhibits apoptosis and induces tumor growth in scid mice.
Bargou, R.C. and Wagener, C. and Bommert, K. and Arnold, W. and Daniel, P.T. and Mapara, M.Y. and Grinstein, E. and Royer, H.D. and Doerken, B.
Journal of Experimental Medicine 183 (3): 1205-1213. 1 March 1996

Induction of cellular immunity in chimpanzees to human tumor associated antigen mucin by vaccination with MUC-1 cDNA-transfected Epstein-Barr virus-immortalized autologous B cells.
Pecher, G. and Finn, O.J.
Proceedings of the National Academy of Sciences of the United States of America 93 (4): 1699-1704. 20 February 1996

Clinical features and outcome of children with first marrow relapse of acute lymphoblastic leukemia expressing BCR-ABL fusion transcripts.
Beyermann, B. and Agthe, A.G. and Adams, H.P. and Seeger, K. and Linderkamp, C. and Goetze, G. and Ludwig, W.D. and Henze, G.
Blood 87 (4): 1532-1538. 15 February 1996

1H-NMR structural analysis of ethidium bromide complexation with self-complementary deoxytetranucleotides 5'-d(ApCpGpT), 5'-d(ApGpCpT), and 5'-d(TpGpCpA) in aqueous solution.
Davies, D.B. and Karawajew, L. and Veselkov, A.N.
Biopolymers 38 (6): 745-757. 1 January 1996

Acute myeloid and T-cell acute lymphoblastic leukaemia with aberrant antigen expression exhibit similar TCRdelta gene rearrangements.
Schmidt, C.A. and Przybylski, G. and Tietze, A. and Oettle, H. and Siegert, W. and Ludwig, W.D.
British Journal of Haematology 92 (4): 929-936. 1 January 1996

Coexpression of interleukin-4 and B7.1 in murine tumor cells leads to improved tumor rejection and vaccine effect compared to single gene transfectants and a classical adjuvant.
Cayeux, S. and Beck, C. and Doerken, B. and Blankenstein, T.
Human Gene Therapy 7 (4): 525-529. 1 January 1996

Development of an enzyme immunoassay for the measurement of human tumour necrosis factor-alpha (hTNF-alpha) using bispecific antibodies to hTNF-alpha and horseradish peroxidase.
Berkova, N. and Karawajew, L. and Korobko, V. and Behrsing, O. and Micheel, B. and Shamborant, O. and Stukatcheva, E. and Shingarova, L.
Biotechnology and Applied Biochemistry 23 Part 2 : 163-171. 1 January 1996

Downegulation of IL-10 secretion and enhanced antigen presenting abilities following HTLV-I infection of T-cells.
Scholz, C. and Hafler, D.A. and Hoellsberg, P.
Journal of Neuroscience Research 45 : 786-794. 1 January 1996

Effects of FLT3 ligand on human leukemia cells. I. proliferative response of myeloid leukemia cells.
Dehmel, U. and Zaborski, M. and Meierhoff, G. and Rosnet, O. and Birnbaum, D. and Ludwig, W.D. and Quentmeier, H. and Drexler, H.G.
Leukemia 10 (2): 261-270. 1 January 1996

Expression of the receptor MPL and proliferative effects of its ligand thrombopoietin on human leukemia cells.
Quentmeier, H. and Zaborski, M. and Graf, G. and Ludwig, W.D. and Drexler, H.G.
Leukemia 10 : 297-310. 1 January 1996

HMG1 - Effected gene transfer using cell cultures and tissue explants xenografted in immunodeficient mice.
Boettger, M. and Arnold, W. and Zaitsev, S. and Vorob'ev, V.I. and Haberland, A. and Schimke, I.
In: Immunodeficient Animals: Models in Cancer Research. Contributions to Oncology ; 51 . Karger, Basel, 36-40. 1 January 1996

High level nuclear NF-kB and Oct-2 is a common feature of cultured Hodgkin/Sternberg cells.
Bargou, R.C. and Leng, C. and Krappmann, D. and Emmerich, F. and Mapara, M.Y. and Bommert, K. and Royer, H.D. and Scheidereit, C. and Doerken, B.
Blood 87 (10): 4340-4347. 1 January 1996

Improved outcome in adult b cell acute lymphoblastic leukemia.
Hoelzer, D. and Ludwig, W.D. and Thiel, E. and Gassmann, W. and Loeffler, H. and Fonatsch, C. and Rieder, H. and Heil, G. and Heinze, B. and Arnold, R. and Hossfeld, D. and Buechner, T. and Koch, P. and Freund, M. and Hiddemann, W. and Maschmeyer, G. and Heyll, A. and Aul, C. and Faak, T. and Kuse, R. and Ittel, T.H. and Gramatzki, M. and Diedrich, H. and Kolbe, K. and Fuhr, H.G. and Fischer, K. and Schadeck-Gressel, C. and Weiss, A. and Strohscheer, I. and Metzner, B. and Fabry, U. and Gokbuget, N. and Volkers, B. and Messerer, D. and Ueberla, K.
Blood 87 (2): 495-508. 1 January 1996

Secondary acute leukaemias with 11q23 rearrangement: clinical, cytogenetic, fish and fiction studies.
Zhao, Y.M. and Poetsch, M. and Weber-Matthiesen, K. and Rohde, G. and Winkemann, M. and Haferlach, T. and Gassmann, W. and Ludwig, W.D. and Grote, W. and Loeffler, H. and Schlegelberger, B.
British Journal of Haematology 92 (3): 673-680. 1 January 1996

The dead end of 5-fluorouracil double modulation and promise of continuous infusion schedules in the treatment of metastatic colorectal cancer.
Koehne, C.H. and Wilke, H. and Schoeffski, P. and Schmoll, H.J.
Journal of Infusional Chemotherapy 6 : 206-210. 1 January 1996

Xenotransplantation of a novel hodgkin cell line HD-MyZ into SCID mice.
Bargou, R.C. and Mapara, M.Y. and Arnold, W. and Daniel, P.T. and Doerken, B.
In: Immunodeficient Animals: Models in Cancer Research. Contributions to Oncology ; 51 . Karger, Basel, 187-192. 1 January 1996

"Sero-switch" adenovirus-mediated in vivo gene transfer: circumvention of anti-adenovirus humoral immune defenses against repeat adenovirus vector administration by changing the adenovirus serotype.
Mastrangeli, A. and Harvey, B.G. and Yao, J. and Wolff, G. and Kovesdi, I. and Crystal, R.G. and Falck-Pedersen, E.
Human Gene Therapy 7 (1): 79-87. January 1996

1995

Clinical significance of surface antigen expression in children with acute myeloid leukemia: results of study AML-BFM-87.
Creutzig, U. and Harbott, J. and Sperling, C. and Ritter, J. and Zimmermann, M. and Loeffler, H. and Riehm, H. and Schellong, G. and Ludwig, W.D.
Blood 86 (8): 3097-3108. 1 October 1995

The receptor tyrosine kinase p185HER2 is expressed on a subset of B-lymphoid blasts from patients with acute lymphoblastic leukemia and chronic myelogenous leukemia.
Buehring, H.J. and Sures, I. and Jallal, B. and Weiss, F.U. and Busch, F.W. and Ludwig, W.D. and Handgretinger, R. and Waller, H.D. and Ullrich, A.
Blood 86 (5): 1916-1923. 1 September 1995

Involvement of NAK-1, the human nur77 homologue, in surface IgM-mediated apoptosis in Burkitt lymphoma cell line BL41.
Mapara, M.Y. and Weinmann, P. and Bommert, K. and Daniel, P.T. and Bargou, R.C. and Doerken, B.
European Journal of Immunology 25 (9): 2506-2510. September 1995

G protein subunit G alpha16 expression is restricted to progenitor B-cells during human B-cell differentiation.
Mapara, M.Y. and Bommert, K. and Bargou, R.C. and Leng, C. and Beck, C. and Ludwig, W.D. and Gierschik, P. and Doerken, B.
Blood 85 (7): 1836-1842. 1 April 1995

Acute leukemia coexpressing myeloid, B- and T-lineage associated markers: multiparameter analysis of criteria defining lineage commitment and maturational stage in a case of undifferentiated leukemia.
Meckenstock, G. and Heyll, A. and Schneider, E.M. and Hildebrandt, B. and Runde, V. and Aul, C. and Bartram, C.R. and Ludwig, W.D. and Schneider, W.
Leukemia 9 : 260-264. 1 January 1995

Aerosol amphotericin b inhalations for prevention of invasive pulmonary aspergillosis in neutropenic cancer patients.
Behre, G.F. and Schwartz, S. and Lenz, K. and Ludwig, W.D. and Schilling, E. and Heinemann, V. and Link, H. and Boenisch, O. and Treder, W. and Siegert, W. and Wandt, H. and Trittin, A. and Hiddemann, W. and Beyer, J.
Annals of Hematology 71 (6): 287-291. 1 January 1995

An effective, direct immunomagnetic procedure for purging acute lymphoblastic leukemia cells from human bone marrow.
Wang, M.Y. and Fostad, O. and Ludwig, W.D. and Bentsson, M. and Totterman, T. and Funderud, S. and Martin, H. and Kvalheim, G.
Pathology and Oncology Research 1 : 32-37. 1 January 1995

Analysis of a family of cyclin-dependent kinase inhibitors: p15/mts2/ink4b, p16/mts1/ink4a, and p18 genes in acute lymphoblastic leukemia of childhood.
Takeuchi, S. and Bartram, C.R. and Seriu, T. and Miller, C.W. and Tobler, A. and Janssen, J.W. and Reiter, A. and Ludwig, W.D. and Zimmermann, M. and Schwaller, J. and Lee, E. and Miyoshi, I. and Koeffler, H.P.
Blood 86 (2): 755-760. 1 January 1995

Clinical, morphologic, cytogenetic and prognostic implications of CD34 expression in childhood and adult de novo AML.
Sperling, C. and Buechner, T. and Creutzig, U. and Ritter, J. and Harbott, J. and Fonatsch, C. and Sauerland, C. and Mielcarek, M. and Maschmeyer, G. and Loeffler, H. and Ludwig, W.D.
Leukemia & Lymphoma 17 : 417-426. 1 January 1995

Expression of the bcl-2 gene family in normal and malignant breast tissue: low bax-alpha expresssion in tumor cells correlates with resistance to apoptosis.
Bargou, R.C. and Daniel, P.T. and Mapara, M.Y. and Bommert, K. and Wagener, C. and Kallinich, B. and Royer, H.D. and Doerken, B.
International Journal of Cancer 60 : 854-859. 1 January 1995

Failure of orally administered dipyridamole to enhance the antineoplastic activity of fluorouracil in combination with leucovorin in patients with advanced colorectal cancer: a prospective randomized trial.
Koehne, C.H. and Hiddemann, W. and Schueller, J. and Weiss, J. and Lohrmann, H.P. and Schmitz-Huebner, U. and Bodenstein, H. and Schoeber, C. and Wilke, H. and Grem, J. and Schmoll, H.J.
Journal of Clinical Oncology 13 : 1201-1208. 1 January 1995

Induction of Bax-alpha precedes apoptosis in a human B lymphoma cell line: potential role of the bcl-2 gene family in surface IgM-mediated apoptosis.
Bargou, R.C. and Bommert, K. and Weinmann, P. and Daniel, P.T. and Wagener, C. and Mapara, M.Y. and Doerken, B.
European Journal of Immunology 25 : 770-775. 1 January 1995

Interferon-alpha does not improve the antineoplastic efficacy of highdose infusional 5-fluorouracil plus folinic acid in advanced colorectal cancer: First results of a randomized multicenter study by the Association of Medical Oncology of the German Cancer Society (AIO).
Koehne, C.H. and Wilke, H. and Hecker, H. and Schoeffski, P. and Kaeufer, C. and Rauschecker, H. and Andreesen, R. and Ohl, U. and Lange, H.J. and Klaassen, U. and Westerhausen, M. and Hiddemann, W. and Hennemann, B. and Schott, G. and Bade, J. and Strohmeyer, G. and Harstrick, A. and Schubert, U. and Bokemeyer, C. and Schmoll, H.J.
Annals of Oncology 6 : 461-466. 1 January 1995

Intrapericardial application of mitoxantrone for treatment of malignant pericardial effusion.
Lentzsch, S. and Reichardt, P. and Guertler, R. and Doerken, B.
Onkologie 17 : 504-507. 1 January 1995

Modulation of cytokine patterns of human autoreactive T cell clones by a single amino acid substitution of their peptide ligand.
Windhagen, A. and Scholz, C. and Hoellsberg, P. and Fukaura, H. and Sette, A. and Hafler, D.A.
Immunity 2 : 373-380. 1 January 1995

Muc-1 epithelial tumor mucin-based immunity and cancer vaccines [review].
Finn, O.J. and Jerome, K.R. and Henderson, R.A. and Pecher, G. and Domenech, N. and Magarian-Blander, J. and Barratt-Boyes, S.M.
Immunological Reviews 145 : 61-89. 1 January 1995

Non-Hodgkin's lymphomas of childhood and adolescence: results of a treatment stratified for biologic subtypes and stage--a report of the Berlin-Frankfurt-Muenster Group.
Reiter, A. and Schrappe, M. and Parwaresch, R. and Henze, G. and Mueller-Weihrich, S. and Sauter, S. and Sykora, K.W. and Ludwig, W.D. and Gadner, H. and Riehm, H.
Journal of Clinical Oncology 13 : 359-372. 1 January 1995

Plexus neuropathy following vaccination against tick-borne encephalitis and tetanus due to a sports related altered immune state.
Sander, D. and Scholz, C. and Eiben, P. and Klingelhoefer, J.
Neurological Research 17 : 316-319. 1 January 1995

The capacity of human malignant B-lymphocytes to disseminate in SCID-mice is correlated with functional expression of the fibronectin receptor alpha5beta1 (CD49e/CD29).
Blase, L. and Daniel, P.T. and Koretz, K. and Schwartz-Albiez, R. and Moeller, P.
International Journal of Cancer 60 : 860-866. 1 January 1995

The fusion of TEL and ABL in human acute lymphoblastic leukaemia is a rare event.
Janssen, J.W. and Ridge, S.A. and Papadopoulos, P. and Cotter, F. and Ludwig, W.D. and Fonatsch, C. and Rieder, H. and Ostertag, W. and Bartram, C.R. and Wiedemann, L.M.
British Journal of Haematology 90 (1): 222-224. 1 January 1995

The thymidine kinase/ganciclovir-mediated "suicide" effect is highly variable in different tumor cells.
Beck, C. and Cayeux, S. and Lupton, S. and Doerken, B. and Blankenstein, T.
Human Gene Therapy 6 (12): 1525-1530. 1 January 1995

Tumor cells cotransfected with interleukin-7 and B7.1 genes induce CD25 and CD28 on tumor-infiltrating T lymphocytes and are strong vaccines.
Cayeux, S. and Beck, C. and Aicher, A. and Doerken, B. and Blankenstein, T.
European Journal of Immunology 25 (8): 2325-2331. 1 January 1995

dic(9;20): a new recurrent chromosome abnormality in adult acute lymphoblastic leukemia.
Rieder, H. and Schnittger, S. and Bodenstein, H. and Schwonzen, M. and Woermann, B. and Berkovic, D. and Ludwig, W.D. and Hoelzer, D. and Fonatsch, C.
Genes Chromosomes & Cancer 13 : 54-61. 1 January 1995

1994

Pre-pre-B acute lymphoblastic leukemia: high frequency of alternatively spliced ALL1-AF4 transcripts and absence of minimal residual disease during complete remission.
Janssen, J.W. and Ludwig, W.D. and Borkhardt, A. and Spadinger, U. and Rieder, H. and Fonatsch, C. and Hossfeld, D.K. and Harbott, J. and Schulz, A.S. and Repp, R. and Sykora, K.W. and Hoelzer, D. and Bartram, C.R.
Blood 84 (11): 3835-3842. 1 December 1994

The role of APO-1-mediated apoptosis in the immune system.
Krammer, P.H. and Dhein, J. and Walczak, H. and Behrmann, I. and Mariani, S. and Matiba, B. and Fath, M. and Daniel, P.T. and Knipping, E. and Westendorp, M.O. and Debatin, K.M.
Immunological Reviews 142 : 175-191. 1 December 1994

Chemotherapy in 998 unselected childhood acute lymphoblastic leukemia patients. Results and conclusions of the multicenter trial ALL-BFM 86.
Reiter, A. and Schrappe, M. and Ludwig, W.D. and Hiddemann, W. and Sauter, S. and Henze, G. and Zimmermann, M. and Lampert, F. and Havers, W. and Niethammer, D. and Odenwald, E. and Ritter, J. and Mann, G. and Welte, K. and Gadner, H. and Riehm, H.
Blood 84 (9): 3122-3133. 1 November 1994

Mechanisms of p53 alteration in acute leukemias.
Schottelius, A. and Brennscheidt, U. and Ludwig, W.D. and Mertelsmann, R.H. and Herrmann, F. and Lubbert, M.
Leukemia 8 : 1673-1681. 1 October 1994

Correlation of cytogenetic findings with clinical features in 18 patients with inv(3)(q21q26) or t(3;3)(q21;q26).
Fonatsch, C. and Gudat, H. and Lengfelder, E. and Wandt, H. and Silling-Engelhardt, G. and Ludwig, W.D. and Thiel, E. and Freund, M. and Bodenstein, H. and Schwieder, G. and Gruenelsen, A. and Aul, C. and Schnittger, S. and Rieder, H. and Haase, D. and Hild, F.
Leukemia 8 (8): 1318-1326. 1 August 1994

Humoral immunity against a tandem repeat epitope of human mucin MUC-1 in sera from breast, pancreatic, and colon cancer patients.
Kotera, Y. and Fontenot, J.D. and Pecher, G. and Metzgar, R.S. and Finn, O.J.
Cancer Research 54 (11): 2856-2860. 1 June 1994

Pulmonary infiltrations in febrile patients with neutropenia. Risk factors and outcome under empirical antimicrobial therapy in a randomized multicenter study.
Maschmeyer, G. and Link, H. and Hiddemann, W. and Meyer, P. and Helmerking, M. and Eisenmann, E. and Schmitt, J. and Adam, D.
Cancer 73 (9): 2296-2304. 1 May 1994

Regulation of Apoptosis in the Immune System.
Krammer, P.H. and Behrmann, I. and Daniel, P.T. and Dhein, J. and Debatin, K.M.
Current Opinion in Immunology 6 (2): 279-289. 1 April 1994

A flow cytometric long-term cytotoxicity assay.
Karawajew, L. and Jung, G. and Wolf, H. and Micheel, B. and Ganzel, K.
Journal of Immunological Methods 177 : 119-130. 1 January 1994

A post-docking role for synaptobrevin in synaptic vesicle fusion.
Hunt, J.M. and Bommert, K. and Charlton, M.P. and Kistner, A. and Haensch, W. and Augustine, G.J. and Betz, H.
Neuron 12 : 1269-1279. 1 January 1994

A simple and sensitive method to study effects mediated by soluble lymphokines as demonstrated by the interaction of CD4+ and CD8+ cell subsets during T cell activation.
Karawajew, L. and Micheel, B. and Jung, G.R. and Wolf, H. and Behrsing, O.
Journal of Immunological Methods 173 : 27-31. 1 January 1994

APO-1 (CD95) mediated apoptosis in human T-ALL engrafted in SCID mice.
Luecking-Famira, K.M. and Daniel, P.T. and Moeller, P. and Krammer, P.H. and Debatin, K.M.
Leukemia 8 : 1825-1833. 1 January 1994

APO-1-mediated apoptosis in normal and malignant lymphocytes.
Dhein, J. and Behrmann, I. and Daniel, P.T. and Debatin, K.M. and Klas, C. and Moller, P. and Oehm, A. and Trauth, B.C. and Walczak, H. and Krammer, P.H.
Biochemical Society Transactions 22 : 598-600. 1 January 1994

Activation induces sensitivity toward APO-1 (CD95)- mediated apoptosis in human B cells.
Daniel, P.T. and Krammer, P.H.
Journal of Immunology 152 : 5624-5632. 1 January 1994

Apoptotic cell death induced by a mouse-human anti-APO-1 chimeric antibody leads to tumor regression.
Coney, L.R. and Daniel, P.T. and Sanborn, D. and Dhein, J. and Debatin, K.M. and Krammer, P.H. and Zurawski, V.R.
International Journal of Cancer 58 : 562-567. 1 January 1994

Characterization of the monocyte-specific esterase (MSE) gene.
Uphoff, C.C. and Hu, Z.B. and Gignac, S.M. and Ma, W. and Rainey, F.A. and Kreutz, M. and Ludwig, W.D. and Drexler, H.G.
Leukemia 8 : 1510-1526. 1 January 1994

Combined immunophenotyping and karyotyping in peripheral T cell lymphomas demonstrating different clonal and nonclonal chromosome aberrations in T helper cells.
Schlegelberger, B. and Weber-Matthiesen, K. and Sterry, W. and Bartels, H. and Sonnen, R. and Maschmeyer, G. and Feller, A.C. and Grote, W.
Leukemia & Lymphoma 15 : 113-125. 1 January 1994

Detection of HRX-FEL fusion transcripts in pre-pre-B-ALL with and without cytogenetic demonstration of t(4;11).
Griesinger, F. and Elfers, H. and Ludwig, W.D. and Falk, M. and Rieder, H. and Harbott, J. and Lampert, F. and Heinze, B. and Hoelzer, D. and Thiel, E. and Riehm, H. and Woermann, B. and Fonatsch, C. and Hiddemann, W.
Leukemia 8 : 542-548. 1 January 1994

Familial adenomatous polyposis: mutation at codon 1309and early onset of colon cancer.
Caspari, R. and Friedl, W. and Mandl, M. and Moslein, G. and Kadmon, M. and Knapp, M. and Jacobasch, K.H. and Ecker, K. and Kreissler-Haag, D. and Timmermanns, G.
Lancet 343 (8898): 629-632. 1 January 1994

Immunophenotypic features of childhood and adult acute lymphoblastic leukemia (ALL): experience of the German Multicentre Trials ALL-BFM and GMALL.
Ludwig, W.D. and Reiter, A. and Loeffler, H. and Goekbuget, N. and Hoelzer, D. and Riehm, H. and Thiel, E.
Leukemia & Lymphoma 13 Suppl. 1 : 71-76. 1 January 1994

Interventional antimicrobial therapy in febrile neutropenic patients. Study Group of the Paul Ehrlich Society for Chemotherapy.
Link, H. and Maschmeyer, G. and Meyer, P. and Hiddemann, W. and Stille, W. and Helmerking, M. and Adam, D.
Annals of Hematology 69 : 231-243. 1 January 1994

Lmphotoxin-alpha/beta heterodimer is expressed on leukemic hairy cells and activated human B lymphocytes.
Mapara, M.Y. and Bargou, R.C. and Beck, C. and Heilig, B. and Doerken, B. and Moldenhauer, G.
International Journal of Cancer 58 : 248-253. 1 January 1994

Molecular characterization of illegitimate TCRdelta gene rearrangements in acute myeloid leukaemia.
Przybylski, G. and Oettle, H. and Ludwig, W.D. and Siegert, W. and Schmidt, C.A.
British Journal of Haematology 87 : 301-307. 1 January 1994

Molecular pathway for presynaptic calcium signaling.
Augustine, G.J. and Betz, H. and Bommert, K. and Charlton, M.P. and DeBello, W.M. and Hans, M. and Swandulla, D.
Advances in Second Messenger and Phosphoprotein Research 29 : 139-154. 1 January 1994

Overexpression of the Raf-1 proto-oncogene in human myeloid leukemia.
Schmidt, C.A. and Oettle, H. and Ludwig, W.D. and Serke, S. and Pawlaczyk-Peter, B. and Wilborn, F. and Binder, L.T. and Huhn, D. and Siegert, W.
Leukemia Research 18 : 409-413. 1 January 1994

Ras point mutations occur in acute myeloid leukemia with illegitimate T-cell receptor delta gene rearrangement.
Schmidt, C.A. and Przybylski, G. and Vogel, D. and Ludwig, W.D. and Oettle, H. and Neubauer, A. and Siegert, W.
Leukemia 8 : 102-105. 1 January 1994

Skipping of multiple CFTR exons is not a result of single exon omissions.
Rickers, A. and Rininsland, F. and Osborne, L. and Reiss, J.
Human Genetics 94 : 311-313. 1 January 1994

t(5;14)(q33-34;q11), a new recurring cytogenetic abnormality in childhood acute leukemia.
Whitlock, J.A. and Raimondi, S.C. and Harbott, J. and Morris, S.W. and McCurley, T.L. and Hansen-Hagge, T.E. and Ludwig, W.D. and Weimann, G. and Bartram, C.R.
Leukemia 8 : 1539-1543. 1 January 1994

1993

Analysis of p53 mutations in a large series of lymphoid hematologic malignancies of childhood.
Wada, M. and Bartram, C.R. and Nakamura, H. and Hachiya, M. and Chen, D.L. and Borenstein, J. and Miller, C.W. and Ludwig, L. and Hansen-Hagge, T.E. and Ludwig, W.D. and Reiter, A. and Mizoguchi, H. and Hoeffler, H.P.
Blood 82 (10): 3163-3169. 15 November 1993

Selective targeting of human lymphokine-activated killer cells by CD3 monoclonal antibody against the interferon-inducible high-affinity Fcgamma RI receptor (CD64) on autologous acute myeloid leukemic blast cells.
Notter, M. and Ludwig, W.D. and Bremer, S. and Thiel, E.
Blood 82 (10): 3113-3124. 15 November 1993

Acute leukemias of different lineages have similar MLL gene fusions encoding related chimeric proteins resulting from chromosomal translocation.
Corral, J. and Forster, A. and Thompson, S. and Lampert, F. and Kaneko, Y. and Slater, R. and Kroes, W.G. and van der Schoot, C.E. and Ludwig, W.D. and Karpas, A. and Pocock, C. and Cotter, F. and Rabitts, T.H.
Proceedings of the National Academy of Sciences of the United States of America 90 (18): 8538-8542. 15 September 1993

Cytolysis of leukemic B-cells by T-cells activated via 2 bispecific antibodies.
Bohlen, H. and Manzke, O. and Patel, B. and Moldenhauer, G. and Doerken, B. and von Fliedner, V. and Diehl, V. and Tesch, H.
Cancer Research 53 (18): 4310-4314. 15 September 1993

Inhibition of neurotransmitter release by C2-domain peptides implicates synaptotagmin in exocytosis.
Bommert, K. and Charlton, M.P. and DeBello, W.M. and Chin, G.J. and Betz, H. and Augustine, G.J.
Nature 363 (6425): 163-165. 13 May 1993

Characterization of a novel Hodgkin cell-line, HD-MyZ, HD-Myr, with myelomonocytic features mimicking Hodgkin's disease in severe combined immunodeficient mice.
Bargou, R.C. and Mapara, M.Y. and Zugck, C. and Daniel, P.T. and Pawlita, M. and Doehner, H. and Doerken, B.
Journal of Experimental Medicine 177 (5): 1257-1268. 1 May 1993

Acute myeloid leukemias expressing lymphoid-associated antigens: diagnostic incidence and prognostic significance.
Drexler, H.G. and Thiel, E. and Ludwig, W.D.
Leukemia 7 (4): 489-498. 1 April 1993

Site-specific deletions involving the tal-1 and sil genes are restricted to cells of the T cell receptor alpha/beta lineage: T cell receptor delta gene deletion mechanism affects multiple genes.
Breit, T.M. and Mol, E.J. and Wolvers-Tettero, I.L. and Ludwig, W.D. and van Wering, E.R. and van Dongen, J.J.
Journal of Experimental Medicine 177 (4): 965-977. 1 April 1993

APO-1 mediated apoptosis or proliferation in human chronic B lymphocytic leukemia: correlation with bcl-2 oncogene expression.
Mapara, M.Y. and Bargou, R.C. and Zugck, C. . and Doehner, H. and Ustaoglu, F. and Jonker, R.R. and Krammer, P.H. and Doerken, B.
European Journal of Immunology 23 (3): 702-708. March 1993

5-Fluorouracil modulation in colorectal carcinoma experience of German investigators.
Koehne-Woempner, C. and Schmoll, H.J.
Advances in Experimental Medicine and Biology 339 : 99-107. 1 January 1993

A pilot study of rapidly alternating epirubicin/dacarbazine and ifosfamide as first-line therapy for metastatic soft-tissue sarcoma in adults.
Harstrick, A. and Bokemeyer, C. and Schmoll, H.J. and Koehne-Woempner, C. and Knipp, H. and Schoeffski, P. and Anagnou, J. and Wipperman, B. and Neumann, S. and Poliwoda, H.
Cancer Chemotherapy and Pharmacology 31 Suppl. 2 : S217-S221. 1 January 1993

Aggressive chemotherapy combined with G-CSF and maintenance therapy with interleukin-2 for patients with advanced myelodysplastic syndrome, subacute or secondary acute myeloid leukemia--initial results.
Ganser, A. and Heil, G. and Kolbe, K. and Maschmeyer, G. and Fischer, J.T. and Bergmann, L. and Mitrou, P.S. and Heit, W. and Heimpel, H. and Huber, C. and Hoelzer, D.
Annals of Hematology 66 : 123-125. 1 January 1993

Antibodies against CD19 and CD22 differentiation antigens for B-lymphoma targeting.
Matzku, S. and Schmid, J. and Kirchgessner, H. and Moldenhauer, G. and Doerken, B. and Bihl, H.
In: Monoclonal Antibodies 2 - Applications in Clinical Oncology. Chapmann & Hall, London, 79-86. 1 January 1993

CD34 expression in de novo acute myeloid leukaemia.
Sperling, C. and Buechner, T. and Sauerland, C. and Fonatsch, C. and Thiel, E. and Ludwig, W.D.
British Journal of Haematology 85 : 635-637. 1 January 1993

Chromosomal abnormalities in adult acute lymphoblastic leukemia: results of the German ALL/AUL Study Group.
Rieder, H. and Ludwig, W.D. and Gassmann, W. and Thiel, E. and Loeffler, H. and Hoelzer, D. and Fonatsch, C.
Recent Results in Cancer Research 131 : 133-148. 1 January 1993

Clinical aspects of acute myeloid leukemias of the FAB types M3 and M4Eo. The AML Cooperative Group.
Haferlach, T. and Gassmann, W. and Loeffler, H. and Juergensen, C. and Noak, J. and Ludwig, W.D. and Thiel, E. and Haase, D. and Fonatsch, C. and Becher, R. and Schlegelberger, B. and Nowrousian, M.R. and Lengfelder, E. and Eimermacher, H. and Weh, H.J. and Braumann, D. and Maschmeyer, G. and Koch, P. and Heinecke, A. and Sauerland, M.C. and Buechner, T.
Annals of Hematology 66 : 165-170. 1 January 1993

Clinical significance of cytogenetic studies in childhood acute lymphoblastic leukemia: experience of the BFM trials.
Harbott, J. and Ritterbach, J. and Ludwig, W.D. and Bartram, C.R. and Reiter, A. and Lampert, F.
Recent Results in Cancer Research 131 : 123-132. 1 January 1993

DNA aneuploidy in childhood acute lymphoblastic leukemia: relation to clinical determinants and prognosis within four consecutive BFM trials.
Hiddemann, W. and Harbott, J. and Ludwig, W.D. and Ritter, J. and Nehmer, A. and Reiter, A. and Kolkmeyer, A. and Laing, T. and Riehm, H.
Recent Results in Cancer Research 131 : 113-121. 1 January 1993

Detection and clinical relevance of genetic abnormalities in pediatric acute lymphoblastic leukemia: a comparison between cytogenetic and polymerase chain reaction analyses.
Izraeli, S. and Janssen, J.W. and Haas, O.A. and Harbott, J. and Brok Simoni, F. and Walther, J.U. and Kovar, H. and Henn, T. and Ludwig, W.D. and Reiter, A. and Rechavi, G. and Bartram, C.R. and Gadner, H. and Lion, T.
Leukemia 7 : 671-678. 1 January 1993

Die immunzytologische Diagnose und Klassifizierung akuter Leukaemien.
Ludwig, W.D. and Schwartz, S. and Martin, M. and Schott, G. and Sperling, C.
Laboratory Medicine 17 : 465-472. 1 January 1993

Elevated plasma prostaglandin E2 levels found in 14 patients undergoing autologous bone marrow or stem cell transplantation.
Cayeux, S. and Beverley, P.C. and Schulz, R. and Doerken, B.
Bone Marrow Transplantation 12 : 603-608. 1 January 1993

Elevated post-stimulatory intracellular adenosine 3,5-cyclic monophosphate (cAMP) levels are found in peripheral blood cells after ABMT.
Cayeux, S. and Beverley, P.C. and Schultz, R. and Doerken, B.
Bone Marrow Transplantation 11 : 483-488. 1 January 1993

Expression of B-cell-associated antigens during B-cell ontogeny.
Doerken, B.
Recent Results in Cancer Research 131 : 9-18. 1 January 1993

Expression of identical E2A/PBX1 fusion transcripts occurs in both pre-B and early pre-B immunological subtypes of childhood acute lymphoblastic leukemia.
Izraeli, S. and Henn, T. and Strobl, H. and Ludwig, W.D. and Kovar, H. and Haas, O.A. and Harbott, J. and Bartram, C.R. and Gadner, H. and Lion, T.
Leukemia 7 : 2054-2056. 1 January 1993

Fatal spleen rupture during induction chemotherapy with RH GM-CSF priming for acute monocytic leukemia. Clinical case report and in vitro studies.
Zimmer, B.M. and Berdel, W.E. and Ludwig, W.D. and Notter, M. and Reufi, B. and Thiel, E.
Leukemia Research 17 : 277-283. 1 January 1993

Follow-up of the first two successive German multicentre trials for adult ALL (01/81 and 02/84).
Hoelzer, D. and Thiel, E. and Ludwig, W.D. and Loeffler, H. and Buechner, T. and Freund, M. and Heil, G. and Hiddemann, W. and Maschmeyer, G. and Voelkers, B. and Goekbuget, N. and Aydemir, U.
Leukemia 7 Suppl. 2 : S130-S134. 1 January 1993

Hybrid hybridomas producing bispecific antibodies to CEA and peroxidase isolated by a combination of HAT medium selection and fluorescence activated cell sorting.
Jantscheff, P. and Winkler, L. and Karawajew, L. and Kaiser, G. and Boettger, M. and Micheel, B.
Journal of Immunological Methods 163 : 91-97. 1 January 1993

Immunophenotype of acute myeloid leukemia: correlation with morphological characteristics and therapy response.
Sperling, C. and Seibt-Jung, H. and Gassmann, W. and Komischke, B. and Sauerland, C. and Hiddemann, W. and Loeffler, H. and Buechner, T. and Thiel, E. and Ludwig, W.D.
Recent Results in Cancer Research 131 : 381-392. 1 January 1993

Incidence and prognostic significance of immunophenotypic subgroups in childhood acute lymphoblastic leukemia: experience of the BFM study 86.
Ludwig, W.D. and Harbott, J. and Bartram, C.R. and Komischke, B. and Sperling, C. and Teichmann, J.V. and Seibt-Jung, H. and Notter, M. and Odenwald, E. and Nehmer, A. and Thiel, E. and Riehm, H.
Recent Results in Cancer Research 131 : 269-282. 1 January 1993

Increased serum levels of granulocyte colony-stimulating factor after autologous bone marrow or blood stem cell transplantation.
Haas, R. and Gericke, G. and Witt, B. and Cayeux, S. and Hunstein, W.
Experimental Hematology 21 (1): 109-113. 1 January 1993

Infektionen bei neutropenischen Patienten.
Maschmeyer, G.
Chemotherapie Journal 2 : 55-62. 1 January 1993

Monoclonal antibody uptake in B-cell lymphomas: experimental studies in nude mouse xenografts.
Schmid, J. and Moeller, P. and Moldenhauer, G. and Doerken, B. and Bihl, H. and Matzku, S.
Cancer Immunology Immunotherapy 36 : 274-280. 1 January 1993

Preclinical studies of T-cell-mediated immune responses against autologous tumor cells in patients with acute leukemia.
Notter, M. and Ludwig, W.D. and Thiel, E.
Recent Results in Cancer Research 131 : 215-222. 1 January 1993

Regulation of protooncogenes and cytokine genes in acute lymphoblastic leukemia.
Tesch, H. and Juecker, M. and Abts, H. and Laumann, R. and Ludwig, W.D. and Pahl, I.
Recent Results in Cancer Research 131 : 239-247. 1 January 1993

SIL-TAL1 deletion in T-cell acute lymphoblastic leukemia.
Janssen, J.W. and Ludwig, W.D. and Sterry, W. and Bartram, C.R.
Leukemia 7 : 1204-1210. 1 January 1993

Susceptibility of human leukemia cells to allogeneic and autologous lymphokine-activated killer cells and its augmentation by exposure of leukemia target cells to cytotoxic drugs in vitro and in vivo.
Teichmann, J.V. and Ludwig, W.D. and Thiel, E.
Recent Results in Cancer Research 131 : 223-238. 1 January 1993

Terminal deoxynucleotidyl transferase (TdT) expression in acute myeloid leukemia.
Drexler, H.G. and Sperling, C. and Ludwig, W.D.
Leukemia 7 : 1142-1150. 1 January 1993

The role of GM-CSF in the treatment of acute myeloid leukemia.
Buechner, T. and Hiddemann, W. and Woermann, B. and Rottmann, R. and Maschmeyer, G. and Ludwig, W.D. and Zuehlsdorf, M. and Buntkirchen, K. and Sander, A. and Aswald, J. and Binder, I. and Prisett, S. and Sauerland, M.C.
Leukemia & Lymphoma 11 Suppl. 2 : 21-24. 1 January 1993

Translocation t(1;22) mimicking t(1;19) in a child with acute lymphoblastic leukemia as revealed by chromosome painting.
Rieder, H. and Kolbus, U. and Koop, U. and Ludwig, W.D. and Stollmann-Gibbels, B. and Fonatsch, C.
Leukemia 7 : 1663-1666. 1 January 1993

Use of the quinolones for the prophylaxis and therapy of infections in immunocompromised hosts.
Maschmeyer, G.
Drugs 45 Suppl. 3 : 73-80. 1 January 1993

tal-1 deletions in T-cell acute lymphoblastic leukemia as PCR target for detection of minimal residual disease.
Breit, T.M. and Beishuizen, A. and Ludwig, W.D. and Mol, E.J. and Adriaansen, H.J. and van Wering, E.R. and van Dongen, J.J.
Leukemia 7 : 2004-2011. 1 January 1993

1992

Polymerase chain reaction monitoring shows a high efficacy of clinical immunomagnetic purging in patients with centroblastic- centrocytic non-Hodgkin's lymphoma.
Straka, C. and Kroner, C. and Doerken, B. and Kvalheim, G.
Blood 80 (10): 2688-2690. 15 November 1992

GM-CSF in the treatment of acute myeloid leukemia.
Hiddemann, W. and Maschmeyer, G. and Ludwig, W.D. and Koenigsmann, M. and Zuehlsdorf, M. and Woermann, B. and Boeckmann, A. and Agion-Freire, E. and Innig, G. and Reuter, C.
Pathologie Biologie 39 : 959. 1 November 1992

AMSA combination chemotherapy in patients with acute myelogenous leukemia unsuitable for standard antileukemic treatment.
Maschmeyer, G. and Willborn, K. and Heit, W.
Leukemia & Lymphoma 8 : 365-369. 1 January 1992

Autologous bone marrow transplantation in patients wiht acute lymphoblastic leukemia in second or subsequent complete remission.
Haas, R. and Doerken, B. and Ogniben, F. and Hohaus, S. and Witt, B. and Hunstein, W.
In: Acute Leukemias - Pharmacokinetics. Haematology and Blood Transfusion ; 34 . Springer, Berlin [u.a.], 549-554. 1 January 1992

Bispecific IgA/IgM antibodies and their use in enzyme immunoassay.
Behrsing, O. and Kaiser, G. and Karawajew, L. and Micheel, B.
Journal of Immunological Methods 156 : 69-77. 1 January 1992

Combined effect of very early intensification and prolonged post- remission chemotherapy in patients with AML.
Buechner, T. and Hiddemann, W. and Schaefer, U.W. and Loeffler, H. and Maschmeyer, G. and Ludwig, W.D. and Aul, C. and Lathan, B. and Heinecke, A.
Leukemia 6 Suppl. 4 : 68-70. 1 January 1992

Human Lyb-2 homolog CD72 is a marker for progenitor B-cell leukemias.
Schwarting, R. and Castello, R. and Moldenhauer, G. and Pezzutto, A. and von Hoegen, I. and Ludwig, W.D. and Parnes, J.R. and Doerken, B.
American Journal of Hematology 41 : 151-158. 1 January 1992

Longterm effects of prolonged maintenance and of very early intensification chemotherapy in AML: data from AMLCG.
Buechner, T. and Hiddemann, W. and Woermann, B. and Loeffler, H. and Maschmeyer, G. and Hossfeld, D. and Ludwig, W.D. and Nowrousian, M. and Aul, C. and Schaefer, U.W.
Leukemia 6 Suppl 2 : 68-71. 1 January 1992

Selective oral antimicrobial prophylaxis for the prevention of infection in acute leukaemia-ciprofloxacin versus co-trimoxazole plus colistin.
Donnelly, J.P. and Maschmeyer, G. and Daenen, S.
European Journal of Cancer 28A : 873-878. 1 January 1992

Successful autologous transplantation of immunomagnetic bead purged bone marrow in non-Hodgkin's lymphoma.
Ogniben, E. and Hohaus, S. and Kvalheim, G. and Doerken, B. and Haas, R.
Progress in Clinical and Biological Research 377 : 189-195. 1 January 1992

TNFalpha therapy activates human B-lymphoma cells in vivo and may protect myelopoiesis.
Heilig, B. and Mapara, M.Y. and Bargou, R.C. and Fiehn, C. and Doerken, B.
Leukemia Research 16 : 769-773. 1 January 1992

Treatment of relapsed or refractory adult acute lymphocytic leukemia.
Freund, M. and Diedrich, H. and Ganser, A. and Gramatzki, M. and Heil, G. and Heyll, A. and Henke, M. and Hiddemann, W. and Haas, R. and Kuse, R. and Koch, P. and Link, H. and Maschmeyer, G. and Planker, M. and Queisser, W. and Schadeck-Gressel, C. and Schmitz, N. and von Verschuer, U. and Wilhelm, S. and Thiel, E. and Hoelzer, D.
Cancer 69 : 709-716. 1 January 1992

The German multicentre trials for treatment of acute lymphoblastic leukemia in adults. The German Adult ALL Study Group.
Hoelzer, D. and Thiel, E. and Ludwig, W.D. and Loeffler, H. and Buechner, T. and Freund, M. and Heil, G. and Hiddemann, W. and Maschmeyer, G. and Voelkers, B. and Aydemir, U.
Leukemia 6 (Suppl. 2): 175-177. 1992

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