Browse by Research Team

2018

The AP-1-BATF and -BATF3 module is essential for growth, survival and TH17/ILC3 skewing of anaplastic large cell lymphoma.
Schleussner, N., Merkel, O., Costanza, M., Liang, H.C., Hummel, F., Romagnani, C., Durek, P., Anagnostopoulos, I., Hummel, M., Jöhrens, K., Niedobitek, A., Griffin, P.R., Piva, R., Sczakiel, H.L., Woessmann, W., Damm-Welk, C., Hinze, C., Stoiber, D., Gillissen, B., Turner, S.D., Kaergel, E., von Hoff, L., Grau, M., Lenz, G., Dörken, B., Scheidereit, C., Kenner, L., Janz, M. and Mathas, S.
Leukemia 32 (9): 1994-2007. September 2018

Targeting the senescence-overriding cooperative activity of structurally unrelated H3K9 demethylases in melanoma.
Yu, Y., Schleich, K., Yue, B., Ji, S., Lohneis, P., Kemper, K., Silvis, M.S., Qutob, N., van Rooijen, E., Werner-Klein, M., Li, L., Dhawan, D., Meierjohann, S., Reimann, M., Elkahloun, A., Treitschke, S., Dörken, B., Speck, C., Mallette, F.A., Zon, L.I., Holmen, S.L., Peeper, D.S., Samuels, Y., Schmitt, C.A. and Lee, S.
Cancer Cell 33 (2): 322-336. 12 February 2018

Senescence-associated reprogramming promotes cancer stemness.
Milanovic, M., Fan, D.N.Y., Belenki, D., Däbritz, J.H.M., Zhao, Z., Yu, Y., Dörr, J.R., Dimitrova, L., Lenze, D., Monteiro Barbosa, I.A., Mendoza-Parra, M.A., Kanashova, T., Metzner, M., Pardon, K., Reimann, M., Trumpp, A., Dörken, B., Zuber, J., Gronemeyer, H., Hummel, M., Dittmar, G., Lee, S. and Schmitt, C.A.
Nature 553 (7686): 96-100. 4 January 2018

A transgenic dual-luciferase reporter mouse for longitudinal and functional monitoring of T cells in vivo.
Szyska, M., Herda, S., Althoff, S., Heimann, A., Russ, J., D'Abundo, D., Dang, T.M., Durieux, I., Dörken, B., Blankenstein, T. and Na, I.K.
Cancer Immunology Research 6 (1): 110-120. January 2018

2017

Inactivation of the putative ubiquitin-E3 ligase PDLIM2 in classical Hodgkin and anaplastic large cell lymphoma.
Wurster, K.D., Hummel, F., Richter, J., Giefing, M., Hartmann, S., Hansmann, M.L., Kreher, S., Köchert, K., Krappmann, D., Klapper, W., Hummel, M., Wenzel, S.S., Lenz, G., Janz, M., Dörken, B., Siebert, R. and Mathas, S.
Leukemia 31 (3): 602-613. March 2017

2016

Multiple myeloma cells modify VEGF/IL-6 levels and osteogenic potential of bone marrow stromal cells via Notch/miR-223.
Berenstein, R., Nogai, A., Waechter, M., Blau, O., Kuehnel, A., Schmidt-Hieber, M., Kunitz, A., Pezzutto, A., Dörken, B. and Blau, I.W.
Molecular Carcinogenesis 55 (12): 1927-1939. December 2016

BCR-ABL-positive acute myeloid leukemia: a new entity? Analysis of clinical and molecular features.
Neuendorff, N.R., Burmeister, T., Doerken, B. and Westermann, J.
Annals of Hematology 95 (8): 1211-1221. August 2016

CCL4 as an adjuvant for DNA vaccination in a Her2/neu mouse tumor model.
Nguyen-Hoai, T., Pham-Duc, M., Gries, M., Dörken, B., Pezzutto, A. and Westermann, J.
Cancer Gene Therapy 23 (6): 162-167. June 2016

Longitudinal study to assess the clinical significance of MSI2 expression in chronic myeloid keukemia patients.
Kaeda, J., Ringel, F., Oberender, C., Gresse, M., Amini, L., Schwarz, M., Doerken, B. and le Coutre, P.
Acta Haematologica 136 (1): 62-64. June 2016

DC generation from peripheral blood mononuclear cells in patients with chronic myeloid leukemia: Influence of interferons on DC yield and functional properties.
Floercken, A., Kopp, J., Kölsch, U., Meisel, C., Dörken, B., Pezzutto, A. and Westermann, J.
Human Vaccines & Immunotherapeutics 12 (5): 1117-1123. 3 May 2016

CD20-targeting immunotherapy promotes cellular senescence in B-cell lymphoma.
Däbritz, J.H.M., Yu, Y., Milanovic, M., Schönlein, M., Rosenfeldt, M.T., Dörr, J.R., Kaufmann, A.M., Dörken, B. and Schmitt, C.A.
Molecular Cancer Therapeutics 15 (5): 1074-1081. May 2016

Second-line treatment in pancreatic cancer patients: Who profits? Results from the CONKO study group.
Sinn, M., Daelken, L., Striefler, J.K., Bischoff, S., Schweitzer, N., Pelzer, U., Doerken, B., Riess, H. and Stieler, J.M.
Pancreas 45 (4): 601-605. April 2016

2015

Frequent induction of chromosomal aberrations in in vivo skin fibroblasts after allogeneic stem cell transplantation: hints to chromosomal instability after irradiation.
Massenkeil, G., Zschieschang, P., Thiel, G., Hemmati, P.G., Budach, V., Doerken, B., Pross, J. and Arnold, R.
Radiation Oncology 10 : 266. 30 December 2015

Allogeneic stem cell transplantation for refractory acute myeloid leukemia: a single center analysis of long-term outcome.
Hemmati, P.G., Terwey, T.H., Na, I.K., Jehn, C.F., le Coutre, P., Vuong, L.G., Doerken, B. and Arnold, R.
European Journal of Haematology 95 (6): 498-506. December 2015

Myeloid-derived suppressor cells in human peripheral blood: optimized quantification in healthy donors and patients with metastatic renal cell carcinoma.
Flörcken, A., Takvorian, A., Singh, A., Gerhardt, A., Ostendorf, B.N., Dörken, B., Pezzutto, A. and Westermann, J.
Immunology Letters 168 (2): 260-267. December 2015

Apoptosis-susceptibility prolongs the lack of memory B cells in acute leukemic patients after allogeneic hematopoietic stem cell transplantation.
Mensen, A., Oh, Y., Becker, S.C., Hemmati, P.G., Jehn, C., Westermann, J., Szyska, M., Göldner, H., Dörken, B., Scheibenbogen, C., Arnold, R. and Na, I.K.
Biology of Blood and Marrow Transplantation 21 (11): 1895-1906. November 2015

Flow cytometric maturity score as a novel prognostic parameter in patients with acute myeloid leukemia.
Schneider, T., Flörcken, A., Singh, A., Türkmen, S., Burmeister, T., Anagnostopoulos, I., Pezzutto, A., Dörken, B. and Westermann, J.
Annals of Hematology 94 (8): 1337-1345. August 2015

Anti-CD22 and anti-CD79B antibody drug conjugates are active in different molecular diffuse large B-cell lymphoma subtypes.
Pfeifer, M., Zheng, B., Erdmann, T., Koeppen, H., McCord, R., Grau, M., Staiger, A., Chai, A., Sandmann, T., Madle, H., Doerken, B., Chu, Y.W., Chen, A.I., Lebovic, D., Salles, G.A., Czuczman, M.S., Palanca-Wessels, M.C., Press, O.W., Advani, R., Morschhauser, F., Cheson, B.D., Lenz, P., Ott, G., Polson, A.G., Mundt, K.E. and Lenz, G.
Leukemia 29 (7): 1578-1586. July 2015

Up-regulated MSI2 is associated with more aggressive chronic myeloid leukemia.
Kaeda, J., Ringel, F., Oberender, C., Mills, K., Quintarelli, C., Pane, F., Koschmieder, S., Slany, R., Schwarzer, R., Saglio, G., Hemmati, P., van Lessen, A., Amini, L., Greese, M., Vagge, E., Burmeister, T., Serra, A., Carson, A., Schwarz, M., Westermann, J., Jundt, F., Doerken, B. and le Coutre, P.
Leukemia & Lymphoma 56 (7): 2105-2113. July 2015

Efficacy of prophylactic low-molecular weight heparin for ambulatory patients with advanced pancreatic cancer: outcomes from the CONKO-004 trial.
Pelzer, U., Opitz, B., Deutschinoff, G., Stauch, M., Reitzig, P.C., Hahnfeld, S., Mueller, L., Grunewald, M., Stieler, J.M., Sinn, M., Denecke, T., Bischoff, S., Oettle, H., Doerken, B. and Riess, H.
Journal of Clinical Oncology 33 (18): 2028-2034. 20 June 2015

The origins of ALK translocations.
Roukos, V. and Mathas, S.
Frontiers in Bioscience 7 : 260-268. 1 June 2015

Quantitative detection of DNMT3A R882H mutation in acute myeloid leukemia.
Berenstein, R., Blau, I.W., Suckert, N., Baldus, C., Pezzutto, A., Dörken, B. and Blau, O.
Journal of Experimental & Clinical Cancer Research 34 (1): 55. 22 May 2015

Differential expression of SHP-1 in chronic myeloid leukemia.
Kaeda, J., Neuman, D., Bonecker, S., Mills, K., Oberender, C., Amini, L., Ringel, F., Serra, A., Schwarz, M., Doerken, B., Zalcberg, I. and Le Coutre, P.
Leukemia & Lymphoma 56 (5): 1547-1549. May 2015

Impact of early remission by induction therapy on allogeneic stem cell transplantation for acute myeloid leukemia with an intermediate risk karyotype in first complete remission.
Hemmati, P.G., Terwey, T.H., Na, I.K., le Coutre, P., Jehn, C.F., Vuong, L.G., Dörken, B. and Arnold, R.
European Journal of Haematology 94 (5): 431-438. May 2015

The IL-15 cytokine system provides growth and survival signals in hodgkin lymphoma and enhances the inflammatory phenotype of HRS cells.
Ullrich, K., Blumenthal-Barby, F., Lamprecht, B., Koechert, K., Lenze, D., Hummel, M., Mathas, S., Doerken, B. and Janz, M.
Leukemia 29 (5): 1213-1218. May 2015

Gene expression profiling of peripheral blood mononuclear cells during treatment with a gene-modified allogeneic tumor cell vaccine in advanced renal cell cancer: tumor-induced immunosuppression and a possible role for NF-κB.
Flörcken, A., Grau, M., Wolf, A., Weilemann, A., Kopp, J., Dörken, B., Blankenstein, T., Pezzutto, A., Lenz, P., Lenz, G. and Westermann, J.
International Journal of Cancer 136 (8): 1814-1826. 15 April 2015

Omission of dacarbazine or bleomycin, or both, from the ABVD regimen in treatment of early-stage favourable Hodgkin's lymphoma (GHSG HD13): an open-label, randomised, non-inferiority trial.
Behringer, K., Goergen, H., Hitz, F., Zijlstra, J.M., Greil, R., Markova, J., Sasse, S., Fuchs, M., Topp, M.S., Soekler, M., Mathas, S., Meissner, J., Wilhelm, M., Koch, P., Lindemann, H.W., Schalk, E., Semrau, R., Kriz, J., Vieler, T., Bentz, M., Lange, E., Mahlberg, R., Hassler, A., Vogelhuber, M., Hahn, D., Mezger, J., Krause, S.W., Skoetz, N., Böll, B., von Tresckow, B., Diehl, V., Hallek, M., Borchmann, P., Stein, H., Eich, H. and Engert, A.
Lancet 385 (9976): 1418-1427. 11 April 2015

Cytokine and proinflammatory gene expression in classical Hodgkin lymphoma: its more than NF-κB!
Kreher, S., Cauchy, P., Bonifer, C. and Mathas, S.
Cytokine 72 (1): 115-117. March 2015

Multiple myeloma cells alter the senescence phenotype of bone marrow mesenchymal stromal cells under participation of the DLK1-DIO3 genomic region.
Berenstein, R., Blau, O., Nogai, A., Waechter, M., Slonova, E., Schmidt-Hieber, M., Kunitz, A., Pezzutto, A., Doerken, B. and Blau, I.W.
BMC Cancer 15 (1): 68. 18 February 2015

Essential role of IRF4 and MYC signaling for survival of anaplastic large cell lymphoma.
Weilemann, A., Grau, M., Erdmann, T., Merkel, O., Sobhiafshar, U., Anagnostopoulos, I., Hummel, M., Siegert, A., Hayford, C., Madle, H., Wollert-Wulf, B., Fichtner, I., Dörken, B., Dirnhofer, S., Mathas, S., Janz, M., Emre, N.C.T., Rosenwald, A., Ott, G., Lenz, P., Tzankov, A. and Lenz, G.
Blood 125 (1): 124-132. 1 January 2015

BCR-ABL1 acute myeloid leukemia: clonal selection of a BCR-ABL1(-) subclone as a cause of refractory disease with nilotinib treatment.
Neuendorff, N.R., Schwarz, M., Hemmati, P., Tuerkmen, S., Bommer, C., Burmeister, T., Doerken, B., le Coutre, P., Arnold, R. and Westermann, J.
Acta Haematologica 133 (2): 237-241. 2015

2014

Access to follicular dendritic cells is a pivotal step in murine chronic lymphocytic leukemia B cell activation and proliferation.
Heinig, K., Gätjen, M., Grau, M., Stache, V., Anagnostopoulos, I., Gerlach, K., Niesner, R.A., Cseresnyes, Z., Hauser, A.E., Lenz, P., Hehlgans, T., Brink, R., Westermann, J., Dörken, B., Lipp, M., Lenz, G., Rehm, A. and Höpken, U.E.
Cancer Discovery 4 : 1448-1465. December 2014

Clinical lessons to be learned from patients developing chronic myeloid leukemia while on immunosuppressive therapy after solid organ transplantation: yet another dase after orthotopic heart transplantation.
Oberender, C., Kleeberg, L., Nienhues, N., Gresse, M., Doerken, B., Riess, H. and le Coutre, P.
Case Reports in Hematology 2014 : 890438. 16 November 2014

α-smooth muscle actin expression and desmoplastic stromal reaction in pancreatic cancer: results from the CONKO-001 study.
Sinn, M., Denkert, C., Striefler, J.K., Pelzer, U., Stieler, J.M., Bahra, M., Lohneis, P., Doerken, B., Oettle, H., Riess, H. and Sinn, B.V.
British Journal of Cancer 111 (10): 1917-1923. 11 November 2014

Mapping of transcription factor motifs in active chromatin identifies IRF5 as key regulator in classical Hodgkin lymphoma.
Kreher, S., Bouhlel, M.A., Cauchy, P., Lamprecht, B., Li, S., Grau, M., Hummel, F., Köchert, K., Anagnostopoulos, I., Jöhrens, K., Hummel, M., Hiscott, J., Wenzel, S.S., Lenz, P., Schneider, M., Küppers, R., Scheidereit, C., Giefing, M., Siebert, R., Rajewsky, K., Lenz, G., Cockerill, P.N., Janz, M., Dörken, B., Bonifer, C. and Mathas, S.
Proceedings of the National Academy of Sciences of the United States of America 111 (42): E4513-E4522. 21 October 2014

Comparison of chimerism and minimal residual disease monitoring for relapse prediction after allogeneic stem cell transplantation for adult acute lymphoblastic leukemia.
Terwey, T.H., Hemmati, P.G., Nagy, M., Pfeifer, H., Goekbuget, N., Brueggemann, M., Le Duc, T.M., le Coutre, P., Doerken, B. and Arnold, R.
Biology of Blood and Marrow Transplantation 20 (10): 1522-1529. October 2014

Dendritic cell-mediated survival signals in Eμ-Myc B-cell lymphoma depend on the transcription factor C/EBPβ.
Rehm, A., Gätjen, M., Gerlach, K., Scholz, F., Mensen, A., Gloger, M., Heinig, K., Lamprecht, B., Mathas, S., Bégay, V., Leutz, A., Lipp, M., Dörken, B. and Höpken, U.E.
Nature Communications 5 : 5057. 30 September 2014

Second-line oxaliplatin, folinic acid, and fluorouracil versus folinic acid and fluorouracil alone for gemcitabine-refractory pancreatic cancer : outcomes from the CONKO-003 trial.
Oettle, H., Riess, H., Stieler, J.M., Heil, G., Schwaner, I., Seraphin, J., Goerner, M., Moelle, M., Greten, T.F., Lakner, V., Bischoff, S., Sinn, M., Doerken, B. and Pelzer, U.
Journal of Clinical Oncology 32 (23): 2423-2429. 10 August 2014

High prevalence of immunoglobulin light chain gene aberrations as revealed by FISH in multiple myeloma and MGUS.
Tuerkmen, S., Binder, A., Gerlach, A., Niehage, S., Melissari, M.T., Inandiklioglu, N., Doerken, B. and Burmeister, T.
Genes Chromosomes & Cancer 53 (8): 650-656. August 2014

Notch pathway inhibition controls myeloma bone disease in the murine MOPC315.BM model.
Schwarzer, R., Nickel, N., Godau, J., Willie, B.M., Duda, G.N., Schwarzer, R., Cirovic, B., Leutz, A., Manz, R., Bogen, B., Dörken, B. and Jundt, F.
Blood Cancer Journal 4 : e217. 13 June 2014

SPARC expression in resected pancreatic cancer patients treated with Gemcitabine: results from the CONKO-001 study.
Sinn, M., Sinn, B.V., Striefler, J.K., Lindner, J.L., Stieler, J.M., Lohneis, P., Bischoff, S., Blaeker, H., Pelzer, U., Neuhaus, P., Dietel, M., Doerken, B., Oettle, H., Riess, H. and Denkert, C.
Annals of Oncology 25 (5): 1025-1032. May 2014

Intensified chemotherapy and simultaneous treatment with heparin in outpatients with pancreatic cancer - the CONKO 004 pilot trial.
Pelzer, U., Hilbig, A., Stieler, J.M., Bahra, M., Sinn, M., Gebauer, B., Doerken, B. and Riess, H.
BMC Cancer 14 (1): 204. 19 March 2014

Peripheral blood sCD3(-) CD4(+) T cells: a useful diagnostic tool in angioimmunoblastic T cell lymphoma.
Singh, A., Schabath, R., Ratei, R., Stroux, A., Klemke, C.D., Nebe, T., Flörcken, A., van Lessen, A., Anagnostopoulos, I., Dörken, B., Ludwig, W.D., Pezzutto, A. and Westermann, J.
Hematological Oncology 32 (1): 16-21. March 2014

Cytogenetic risk grouping by the monosomal karyotype classification is superior in predicting the outcome of acute myeloid leukemia undergoing allogeneic stem cell transplantation in complete remission.
Hemmati, P.G., Schulze-Luckow, A., Terwey, T.H., le Coutre, P., Vuong, L.G., Doerken, B. and Arnold, R.
European Journal of Haematology 92 (2): 102-110. February 2014

Effects of Jak2 type 1 inhibitors NVP-BSK805 and NVP-BVB808 on Jak2 mutation-positive and Bcr-Abl-positive cell lines.
Ringel, F., Kaeda, J., Schwarz, M., Oberender, C., Grille, P., Doerken, B., Marque, F., Manley, P.W., Radimerski, T. and le Coutre, P.
Acta Haematologica 132 (1): 75-86. 31 January 2014

JAK2 V617F allele burden quantified by real time quantitative polymerase chain reaction and competitive polymerase chain reaction in patients with chronic myeloproliferative neoplasia.
Kaeda, J., Bonamino, M., Ayres-Silva, J., Solza, C., Ringel, F., Blau, O., Daumas, A., Oberender, C., Doerken, B., Le Coutre, P. and Zalcberg, I.
Leukemia & Lymphoma 55 (1): 128-135. January 2014

Pharmacological and genomic profiling identifies NF-κB-targeted treatment strategies for mantle cell lymphoma.
Rahal, R., Frick, M., Romero, R., Korn, J.M., Kridel, R., Chun Chan, F., Meissner, B., Bhang, H.E., Ruddy, D., Kauffmann, A., Farsidjani, A., Derti, A., Rakiec, D., Naylor, T., Pfister, E., Kovats, S., Kim, S., Dietze, K., Doerken, B., Steidl, C., Tzankov, A., Hummel, M., Monahan, J., Morrissey, M.P., Fritsch, C., Sellers, W.R., Cooke, V.G., Gascoyne, R.D., Lenz, G. and Stegmeier, F.
Nature Medicine 20 (1): 87-92. January 2014

Transformation and additional malignancies are leading risk factors for an adverse course of disease in marginal zone lymphoma.
Meyer, A.H., Stroux, A., Lerch, K., Eucker, J., Eitle, J., Hohloch, K., Andrzejak, M., Possinger, K., Dörken, B., Pezzutto, A. and Scholz, C.W.
Annals of Oncology 25 (1): 210-215. January 2014

2013

An individual patient-data comparison of combined modality therapy and ABVD alone for patients with limited-stage Hodgkin lymphoma.
Hay, A.E., Klimm, B., Chen, B.E., Goergen, H., Shepherd, L.E., Fuchs, M., Gospodarowicz, M.K., Borchmann, P., Connors, J.M., Markova, J., Crump, M., Lohri, A., Winter, J.N., Doerken, B., Pearcey, R.G., Diehl, V., Horning, S.J., Eich, H.T., Engert, A. and Meyer, R.M.
Annals of Oncology 24 (12): 3065-3069. December 2013

Transition from an autoimmune-prone state to fatal autoimmune disease in CCR7 and RORγt double-deficient mice is dependent on gut microbiota.
Wichner, K., Fischer, A., Winter, S., Tetzlaff, S., Heimesaat, M.M., Bereswill, S., Rehm, A., Lipp, M. and Höpken, U.E.
Journal of Autoimmunity 47 : 58-72. December 2013

Does long-term survival in patients with pancreatic cancer really exist? Results from the CONKO-001 study.
Sinn, M., Striefler, J.K., Sinn, B.V., Sallmon, D., Bischoff, S., Stieler, J.M., Pelzer, U., Bahra, M., Neuhaus, P., Doerken, B., Denkert, C., Riess, H. and Oettle, H.
Journal of Surgical Oncology 108 (6): 398-402. November 2013

Concurrent inhibition of PI3K and mTORC1/mTORC2 overcomes resistance to rapamycin induced apoptosis by down-regulation of Mcl-1 in mantle cell lymphoma.
Mueller, A., Zang, C., Chumduri, C., Doerken, B., Daniel, P.T. and Scholz, C.W.
International Journal of Cancer 133 (8): 1813-1824. 15 October 2013

Rabbit antithymocyte globulin induces rapid expansion of effector memory CD8 T cells without accelerating acute graft versus host disease.
Wittenbecher, F., Rieger, K., Dziubianau, M., Herholz, A., Mensen, A., Blau, I.W., Uharek, L., Dörken, B., Thiel, A. and Na, I.K.
Leukemia Research Reports 2 (2): 82-85. 27 September 2013

IκB-ζ controls the constitutive NF-κB target gene network and survival of ABC DLBCL.
Nogai, H., Wenzel, S.S., Hailfinger, S., Grau, M., Kaergel, E., Seitz, V., Wollert-Wulf, B., Pfeifer, M., Wolf, A., Frick, M., Dietze, K., Madle, H., Tzankov, A., Hummel, M., Dörken, B., Scheidereit, C., Janz, M., Lenz, P., Thome, M. and Lenz, G.
Blood 122 (13): 2242-2250. 26 September 2013

Synthetic lethal metabolic targeting of cellular senescence in cancer therapy.
Dörr, J.R., Yu, Y., Milanovic, M., Beuster, G., Zasada, C., Däbritz, J.H.M., Lisec, J., Lenze, D., Gerhardt, A., Schleicher, K., Kratzat, S., Purfürst, B., Walenta, S., Mueller-Klieser, W., Gräler, M., Hummel, M., Keller, U., Buck, A.K., Dörken, B., Willmitzer, L., Reimann, M., Kempa, S., Lee, S. and Schmitt, C.A.
Nature 501 (7467): 421-425. 19 September 2013

Interventionally implanted port catheter systems for hepatic arterial infusion of chemotherapy in patients with primary liver cancer: a phase II-study (NCT00356161).
Sinn, M., Nicolaou, A., Ricke, J., Podrabsky, P., Seehofer, D., Gebauer, B., Pech, M., Neuhaus, P., Doerken, B., Riess, H. and Hildebrandt, B.
BMC Gastroenterology 13 : 125. 9 August 2013

Hepatic arterial infusion with oxaliplatin and 5-FU/folinic acid for advanced biliary tract cancer: a phase II study.
Sinn, M., Nicolaou, A., Gebauer, B., Podrabsky, P., Seehofer, D., Ricke, J., Doerken, B., Riess, H. and Hildebrandt, B.
Digestive Diseases and Sciences 58 (8): 2399-2405. August 2013

PTEN loss defines a PI3K/AKT pathway-dependent germinal center subtype of diffuse large B-cell lymphoma.
Pfeifer, M., Grau, M., Lenze, D., Wenzel, S.S., Wolf, A., Wollert-Wulf, B., Dietze, K., Nogai, H., Storek, B., Madle, H., Dörken, B., Janz, M., Dirnhofer, S., Lenz, P., Hummel, M., Tzankov, A. and Lenz, G.
Proceedings of the National Academy of Sciences of the United States of America 110 (30): 12420-12425. 23 July 2013

Allogeneic partially HLA-matched dendritic cells pulsed with autologous tumor cell lysate as a vaccine in metastatic renal cell cancer: a clinical phase I/II study.
Flörcken, A., Kopp, J., van Lessen, A., Movassaghi, K., Takvorian, A., Jöhrens, K., Möbs, M., Schönemann, C., Sawitzki, B., Egerer, K., Dörken, B., Pezzutto, A. and Westermann, J.
Human Vaccines & Immunotherapeutics 9 (7): 1217-1227. 1 June 2013

Anti-leukemia T cells in AML: TNF-α(+) CD8(+) T cells may escape detection and possibly reflect a stage of functional impairment.
Flörcken, A., van Lessen, A., Terwey, T.H., Dörken, B., Arnold, R., Pezzutto, A. and Westermann, J.
Human Vaccines & Immunotherapeutics 9 (7): 1200-1204. 1 June 2013

MCL1 is deregulated in subgroups of diffuse large B-cell lymphoma.
Wenzel, S.S., Grau, M., Mavis, C., Hailfinger, S., Wolf, A., Madle, H., Deeb, G., Doerken, B., Thome, M., Lenz, P., Dirnhofer, S., Hernandez-Ilizaliturri, F.J., Tzankov, A. and Lenz, G.
Leukemia 27 (6): 1381-1390. June 2013

Value of carbohydrate antigen 19-9 in predicting response and therapy control in patients with metastatic pancreatic cancer undergoing first-line therapy.
Pelzer, U., Hilbig, A., Sinn, M., Stieler, J., Bahra, M., Doerken, B. and Riess, H.
Frontiers in Oncology 3 : 155. June 2013

Blood group determinates incidence for pancreatic cancer in Germany.
Pelzer, U., Klein, F., Bahra, M., Sinn, M., Doerken, B., Neuhaus, P., Meyer, O. and Riess, H.
Frontiers in Physiology 4 : 118. 24 May 2013

NIH-defined graft-versus-host disease and evidence for a potent graft-versus-leukemia effect in patients with acute lymphoblastic leukemia.
Terwey, T.H., Le Duc, T.M., Hemmati, P.G., le Coutre, P., Nagy, M., Martus, P., Doerken, B. and Arnold, R.
Annals of Oncology 24 (5): 1363-1370. May 2013

Peripheral artery occlusive disease (PAOD) in chronic phase chronic myeloid leukemia patients treated with nilotinib or Imatinib.
Kim, T.D., Rea, D., Schwarz, M., Grille, P., Nicolini, F.E., Rosti, G., Levato, L., Giles, F.J., Dombret, H., Mirault, T., Labussiere, H., Lindhorst, R., Haverkamp, W., Buschmann, I., Doerken, B. and le Coutre, P.D.
Leukemia 27 (6): 1316-1321. 5 April 2013

Structural insights into the mechanism of GTPase activation in the GIMAP family.
Schwefel, D., Arasu, B.S., Marino, S.F., Lamprecht, B., Köchert, K., Rosenbaum, E., Eichhorst, J., Wiesner, B., Behlke, J., Rocks, O., Mathas, S. and Daumke, O.
Structure 21 (4): 550-559. 2 April 2013

2012

A novel mouse model for multiple myeloma (MOPC315.BM) that allows noninvasive spatiotemporal detection of osteolytic disease.
Hofgaard, P.O., Jodal, H.C., Bommert, K., Huard, B., Caers, J., Carlsen, H., Schwarzer, R., Schuenemann, N., Jundt, F., Lindeberg, M.M. and Bogen, B.
PLoS ONE 7 (12): e51892. 20 December 2012

Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL.
Nagel, D., Spranger, S., Vincendeau, M., Grau, M., Raffegerst, S., Kloo, B., Hlahla, D., Neuenschwander, M., von Kries, J.P., Hadian, K., Doerken, B., Lenz, P., Lenz, G., Schendel, D.J. and Krappmann, D.
Cancer Cell 22 (6): 825-837. 11 December 2012

HER2/neu DNA vaccination by intradermal gene delivery in a mouse tumor model: gene gun is superior to jet injector in inducing CTL responses and protective immunity.
Nguyen-Hoai, T., Kobelt, D., Hohn, O., Vu, M.D., Schlag, P.M., Doerken, B., Norley, S., Lipp, M., Walther, W., Pezzutto, A. and Westermann, J.
OncoImmunology 1 (9): 1537-1545. 1 December 2012

CCL19 as an adjuvant for intradermal gene gun immunization in a Her2/neu mouse tumor model: improved vaccine efficacy and a role for B cells as APC.
Nguyen-Hoai, T., Hohn, O., Vu, M.D., Baldenhofer, G., Sayed Ahmed, M.S., Doerken, B., Norley, S., Lipp, M., Pezzutto, A. and Westermann, J.
Cancer Gene Therapy 19 (12): 880-887. December 2012

The sorting receptor sortilin exhibits a dual function in exocytic trafficking of interferon-γ and granzyme A in T cells.
Herda, S., Raczkowski, F., Mittruecker, H.W., Willimsky, G., Gerlach, K., Kuehl, A.A., Breiderhoff, T., Willnow, T.E., Doerken, B., Höpken, U.E. and Rehm, A.
Immunity 37 (5): 854-866. 16 November 2012

Homeostatic chemokines guide lymphoma cells to tumor growth-promoting niches within secondary lymphoid organs.
Höpken, U.E. and Rehm, A.
Journal of Molecular Medicine 90 (11): 1237-1245. November 2012

The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers.
Calado, D.P., Sasaki, Y., Godinho, S.A., Pellerin, A., Köchert, K., Sleckman, B.P., de Alboran, I.M., Janz, M., Rodig, S. and Rajewsky, K.
Nature Immunology 13 (11): 1092-1100. November 2012

The tumour suppressor p53 is frequently nonfunctional in Sezary syndrome.
Lamprecht, B., Kreher, S., Moebs, M., Sterry, W., Doerken, B., Janz, M., Assaf, C. and Mathas, S.
British Journal of Dermatology 167 (2): 240-246. August 2012

Clinical cardiac safety profile of nilotinib.
Kim, T.D., le Coutre, P., Schwarz, M., Grille, P., Levitin, M., Fateh-Moghadam, S., Giles, F.J., Doerken, B., Haverkamp, W. and Koehncke, C.
Haematologica 97 (6): 883-889. June 2012

p14ARF-induced apoptosis in p53-deficient cells is mediated by the BH3-only protein independent de-repression of Bak through down-regulation of Mcl-1 and Bcl-xL.
Muer, A., Overkamp, T., Gillissen, B., Richter, A., Pretzsch, T., Milojkovic, A., Doerken, B., Daniel, P.T. and Hemmati, P.
Journal of Biological Chemistry 287 (21): 17343-17352. 18 May 2012

Reduced-intensity chemotherapy and PET-guided radiotherapy in patients with advanced stage Hodgkin's lymphoma (HD15 trial): a randomised, open-label, phase 3 non-inferiority trial.
Engert, A., Haverkamp, H., Kobe, C., Markova, J., Renner, C., Ho, A., Zijlstra, J., Kral, Z., Fuchs, M., Hallek, M., Kanz, L., Doehner, H., Doerken, B., Engel, N., Topp, M., Klutmann, S., Amthauer, H., Bockisch, A., Kluge, R., Kratochwil, C., Schober, O., Greil, R., Andreesen, R., Kneba, M., Pfreundschuh, M., Stein, H., Eich, H.T., Mueller, R.P., Dietlein, M., Borchmann, P. and Diehl, V.
Lancet 379 (9828): 1791-1799. 12 May 2012

Detection of circulating tumor-associated antigen depends on the domains recognized by the monoclonal antibodies used: N-terminal trimmed EpCAM-levels are much higher than untrimmed forms.
Schmetzer, O., Moldenhauer, G., Nicolaou, A., Schlag, P., Riesenberg, R. and Pezzutto, A.
Immunology Letters 143 (2): 184-192. 30 April 2012

Notch is an essential upstream regulator of NF-κB and is relevant for survival of Hodgkin and Reed-Sternberg cells.
Schwarzer, R., Doerken, B. and Jundt, F.
Leukemia 26 (4): 806-813. April 2012

NIH-defined graft-versus-host disease after reduced intensity or myeloablative conditioning in patients with acute myeloid leukemia.
Terwey, T.H., Vega-Ruiz, A., Hemmati, P.G., Martus, P., Dietz, E., le Coutre, P., Massenkeil, G., Doerken, B. and Arnold, R.
Leukemia 26 (3): 536-542. March 2012

New insights into the biology of molecular subtypes of diffuse large B-cell lymphoma and Burkitt lymphoma.
Frick, M., Doerken, B. and Lenz, G.
Best Practice and Research Clinical Haematology 25 (1): 3-12. March 2012

2011

Eight cycles of escalated-dose BEACOPP compared with four cycles of escalated-dose BEACOPP followed by four cycles of baseline-dose BEACOPP with or without radiotherapy in patients with advanced-stage Hodgkin's lymphoma: final analysis of the HD12 trial of the German Hodgkin study group.
Borchmann, P., Haverkamp, H., Diehl, V., Cerny, T., Markova, J., Ho, A.D., Eich, H.T., Mueller-Hermelink, H.K., Kanz, L., Greil, R., Rank, A., Paulus, U., Smardova, L., Huber, C., Doerken, B., Nerl, C., Krause, S.W., Mueller, R.P., Fuchs, M. and Engert, A.
Journal of Clinical Oncology 29 (32): 4234-4342. 10 November 2011

BAY 43-9006/Sorafenib blocks CSF1R activity and induces apoptosis in various classical Hodgkin lymphoma cell lines.
Ullrich, K., Wurster, K.D., Lamprecht, B., Koechert, K., Engert, A., Doerken, B., Janz, M. and Mathas, S.
British Journal of Haematology 155 (3): 398-402. November 2011

First-line treatment of pancreatic cancer patients with the combination of 5-fluorouracil/folinic acid plus gemcitabine: a multicenter phase II trial by the CONKO-study group.
Pelzer, U., Arnold, D., Reitzig, P., Herrenberger, J., Korsten, F.W., Kindler, M., Stieler, J., Doerken, B., Riess, H. and Oettle, H.
Cancer Chemotherapy and Pharmacology 68 (5): 1173-1178. November 2011

Opposing roles of NF-κB in anti-cancer treatment outcome unveiled by cross-species investigations.
Jing, H., Kase, J., Dörr, J.R., Milanovic, M., Lenze, D., Grau, M., Beuster, G., Ji, S., Reimann, M., Lenz, P., Hummel, M., Doerken, B., Lenz, G., Scheidereit, C., Schmitt, C.A. and Lee, S.
Genes & Development 25 (20): 2137-2146. 15 October 2011

Severe peripheral arterial disease during nilotinib therapy.
Le Coutre, P., Rea, D., Abruzzese, E., Dombret, H., Trawinska, M.M., Herndlhofer, S., Doerken, B. and Valent, P.
Journal of the National Cancer Institute 103 (17): 1347-1348. 7 September 2011

Antigen-presentation capacity of dendritic cells is impaired in ongoing enterovirus myocarditis.
Rahnefeld, A., Ebstein, F., Albrecht, N., Opitz, E., Kuckelkorn, U., Stangl, K., Rehm, A., Kloetzel, P.M. and Voigt, A.
European Journal of Immunology 41 (9): 2774-2781. September 2011

Eukaryotic initiation factor 2α phosphorylation is required for B cell maturation and function in mice.
Mielke, N., Schwarzer, R., Calkhoven, C.F., Kaufman, R., Doerken, B., Leutz, A. and Jundt, F.
Haematologica 96 (9): 1261-1268. September 2011

Malt1-dependent RelB cleavage promotes canonical NF-κB activation in lymphocytes and lymphoma cell lines.
Hailfinger, S., Nogai, H., Pelzer, C., Jaworski, M., Cabalzar, K., Charton, J.E., Guzzardi, M., Decaillet, C., Grau, M., Doerken, B., Lenz, P., Lenz, G. and Thome, M.
Proceedings of the National Academy of Sciences of the United States of America 108 (35): 14596-14601. 30 August 2011

Genomic loss of the putative tumor suppressor gene E2A in human lymphoma.
Steininger, A., Moebs, M., Ullmann, R., Koechert, K., Kreher, S., Lamprecht, B., Anagnostopoulos, I., Hummel, M., Richter, J., Beyer, M., Janz, M., Klemke, C.D., Stein, H., Doerken, B., Sterry, W., Schrock, E., Mathas, S. and Assaf, C.
Journal of Experimental Medicine 208 (8): 1585-1593. 1 August 2011

Manifestation of spontaneous and early autoimmune gastritis in CCR7-deficient mice.
Winter, S., Rehm, A., Wichner, K., Scheel, T., Batra, A., Siegmund, B., Berek, C., Lipp, M. and Höpken, U.E.
American Journal of Pathology 179 (2): 754-765. August 2011

Post-transplantation chronic myeloid leukemia.
le Coutre, P., Schwarz, M., Daniel, P. and Doerken, B.
Clinical Advances in Hematology & Oncology 9 (8): 627-629. August 2011

Cooperative function of CCR7 and lymphotoxin in the formation of a lymphoma-permissive niche within murine secondary lymphoid organs.
Rehm, A., Mensen, A., Schradi, K., Gerlach, K., Wittstock, S., Winter, S., Buechner, G., Doerken, B., Lipp, M. and Höpken, U.E.
Blood 118 (4): 1020-1033. 28 July 2011

Serum/glucocorticoid-regulated kinase 1 (SGK1) is a prominent target gene of the transcriptional response to cytokines in multiple myeloma and supports the growth of myeloma cells.
Fagerli, U.M., Ullrich, K., Stuehmer, T., Holien, T., Koechert, K., Holt, R.U., Bruland, O., Chatterjee, M., Nogai, H., Lenz, G., Shaughnessy, J.D., Mathas, S., Sundan, A., Bargou, R.C., Doerken, B., Borset, M. and Janz, M.
Oncogene 30 (28): 3198-3206. 14 July 2011

Best supportive care (BSC) versus oxaliplatin, folinic acid and 5-fluorouracil (OFF) plus BSC in patients for second-line advanced pancreatic cancer: A phase III-study from the German CONKO-study group.
Pelzer, U., Schwaner, I., Stieler, J., Adler, M., Seraphin, J., Doerken, B., Riess, H. and Oettle, H.
European Journal of Cancer 47 (11): 1676-1681. July 2011

The use of microarray technologies in mantle cell lymphoma.
Ratsch, B.A., Grau, M., Doerken, B., Lenz, P. and Lenz, G.
Seminars in Hematology 48 (3): 166-171. July 2011

Pathogenesis of non-Hodgkin's lymphoma.
Nogai, H., Doerken, B. and Lenz, G.
Journal of Clinical Oncology 29 (14): 1803-1811. 10 May 2011

High-level expression of Mastermind-like 2 contributes to aberrant activation of the NOTCH signaling pathway in human lymphomas.
Koechert, K., Ullrich, K., Kreher, S., Aster, J.C., Kitagawa, M., Joehrens, K., Anagnostopoulos, I., Jundt, F., Lamprecht, B., Zimber-Strobl, U., Stein, H., Janz, M., Doerken, B. and Mathas, S.
Oncogene 30 (15): 1831-1840. 14 April 2011

Protein kinase C inhibitor Sotrastaurin selectively inhibits the growth of CD79-mutant diffuse large B-cell lymphomas.
Naylor, T.L., Tang, H., Ratsch, B.A., Enns, A., Loo, A., Chen, L., Lenz, P., Schuler, W., Doerken, B., Yao, Y.M., Warmuth, M., Lenz, G. and Stegmeier, F.
Cancer Research 71 (7): 2643-2653. 1 April 2011

A modified EBMT risk score predicts the outcome of patients with acute myeloid leukemia receiving allogeneic stem cell transplants.
Hemmati, P.G., Terwey, T.H., le Coutre, P., Vuong, L.G., Massenkeil, G., Doerken, B. and Arnold, R.
European Journal of Haematology 86 (4): 305-316. April 2011

Notch and NF-κB signaling pathways in the biology of classical Hodgkin lymphoma.
Schwarzer, R. and Jundt, F.
Current Molecular Medicine 11 (3): 236-245. April 2011

Critical role of PI3K signaling for NF-κB-dependent survival in a subset of activated B-cell-like diffuse large B-cell lymphoma cells.
Kloo, B., Nagel, D., Pfeifer, M., Grau, M., Duewel, M., Vincendeau, M., Doerken, B., Lenz, P., Lenz, G. and Krappmann, D.
Proceedings of the National Academy of Sciences of the United States of America 108 (1): 272-277. 4 January 2011

Hepatic arterial infusion chemotherapy for liver metastases from gastric cancer: an analysis in western patients.
Floercken, A., Schaefer, C., Bichev, D., Breithaupt, K., Dogan, Y., Schumacher, G., Gebauer, B., Riess, H., Doerken, B. and Thuss-Patience, P.C.
Tumori 97 (1): 19-24. January 2011

2010

Reduced-intensity conditioning using fludarabine and antithymocyte globulin alone allows stable engraftment in a patient with Dyskeratosis congenita.
Vuong, L.G., Hemmati, P.G., Neuburger, S., Terwey, T.H., Vulliamy, T., Dokal, I., Le Coutre, P., Doerken, B. and Arnold, R.
Acta Haematologica 124 (4): 200-203. December 2010

Thyroid dysfunction caused by second-generation tyrosine kinase inhibitors in Philadelphia chromosome-positive chronic myeloid leukemia.
Kim, T.D., Schwarz, M., Nogai, H., Grille, P., Westermann, J., Ploeckinger, U., Braun, D., Schweizer, U., Arnold, R., Doerken, B. and le Coutre, P.
Thyroid 20 (11): 1209-1214. 9 November 2010

Repeat-element driven activation of proto-oncogenes in human malignancies.
Lamprecht, B., Bonifer, C. and Mathas, S.
Cell Cycle 9 (21): 4276-4281. November 2010

Role of EBAG9 protein in coat protein complex I-dependent glycoprotein maturation and secretion processes in tumor cells.
Wolf, J., Reimer, T.A., Schuck, S., Rueder, C., Gerlach, K., Mueller, E.C., Otto, A., Doerken, B. and Rehm, A.
FASEB Journal 24 (10): 4000-4019. October 2010

Intensified chemotherapy and dose-reduced involved-field radiotherapy in patients with early unfavorable Hodgkin's lymphoma: final analysis of the German Hodgkin Study Group HD11 trial.
Eich, H.T., Diehl, V., Goergens, H., Pabst, T., Markova, J., Debus, J., Ho, A., Doerken, B., Rank, A., Grosu, A.L., Wiegel, T., Karstens, J.H., Greil, R., Willich, N., Schmidberger, H., Doehner, H., Borchmann, P., Mueller-Hermelink, H.K., Mueller, R.P. and Engert, A.
Journal of Clinical Oncology 28 (27): 4199-4206. 20 September 2010

Common clonal origin of an acute B lymphoblastic leukemia and a Langerhans' cell sarcoma: evidence for hematopoietic plasticity.
Ratei, R., Hummel, M., Anagnostopoulos, I., Jaehne, D., Arnold, R., Doerken, B., Mathas, S., Thomas, B., Dudeck, O., Ludwig, W.D. and Stein, H.
Haematologica 95 (9): 1461-1466. September 2010

Reduced treatment intensity in patients with early-stage Hodgkin's lymphoma.
Engert, A., Pluetschow, A., Eich, H.T., Lohri, A., Doerken, B., Borchmann, P., Berger, B., Greil, R., Willborn, K.C., Wilhelm, M., Debus, J., Eble, M.J., Soekler, M., Ho, A., Rank, A., Ganser, A., Truemper, L., Bokemeyer, C., Kirchner, H., Schubert, J., Kral, Z., Fuchs, M., Mueller-Hermelink, H.K., Mueller, R.P. and Diehl, V.
New England Journal of Medicine 363 (7): 640-652. 12 August 2010

Cellular senescence predicts treatment outcome in metastasised colorectal cancer.
Haugstetter, A.M., Loddenkemper, C., Lenze, D., Groene, J., Standfuss, C., Petersen, I., Doerken, B. and Schmitt, C.A.
British Journal of Cancer 103 (4): 505-509. 10 August 2010

Fatal immune haemolysis due to antibodies to individual metabolites of 5-fluorouracil.
Yuerek, S., Riess, H., Kreher, S., Doerken, B. and Salama, A.
Transfusion Medicine 20 (4): 265-268. 1 August 2010

A modified EBMT risk score and the hematopoietic cell transplantation-specific comorbidity index for pre-transplant risk assessment in adult acute lymphoblastic leukemia.
Terwey, T.H., Hemmati, P.G., Martus, P., Dietz, E., Vuong, L.G., Massenkeil, G., Doerken, B. and Arnold, R.
Haematologica 95 (5): 810-818. May 2010

Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma.
Lamprecht, B., Walter, K., Kreher, S., Kumar, R., Hummel, M., Lenze, D., Koechert, K., Bouhlel, M.A., Richter, J., Soler, E., Stadhouders, R., Joehrens, K., Wurster, K.D., Callen, D.F., Harte, M.F., Giefing, M., Barlow, R., Stein, H., Anagnostopoulos, I., Janz, M., Cockerill, P.N., Siebert, R., Doerken, B., Bonifer, C. and Mathas, S.
Nature Medicine 16 (5): 571-579, 1p following 579. May 2010

Reduced intensity conditioning prior to allogeneic stem cell transplantation in first complete remission is effective in patients with acute myeloid leukemia and an intermediate-risk karyotype.
Hemmati, P.G., Terwey, T.H., Massenkeil, G., le Coutre, P., Vuong, L.G., Neuburger, S., Doerken, B. and Arnold, R.
International Journal of Hematology 91 (3): 436-445. April 2010

Tumor stroma-derived TGF-beta limits Myc-driven lymphomagenesis via Suv39h1-dependent senescence.
Reimann, M., Lee, S., Loddenkemper, C., Dörr, J.R., Tabor, V., Aichele, P., Stein, H., Doerken, B., Jenuwein, T. and Schmitt, C.A.
Cancer Cell 17 (3): 262-272. 16 March 2010

Parenteral nutrition support for patients with pancreatic cancer. Results of a phase II study.
Pelzer, U., Arnold, D., Govercin, M., Stieler, J., Doerken, B., Riess, H. and Oettle, H.
BMC Cancer 10 (1): 86. 9 March 2010

C/EBPbetaDeltauORF mice--a genetic model for uORF-mediated translational control in mammals.
Wethmar, K., Bégay, V., Smink, J.J., Zaragoza, K., Wiesenthal, V., Doerken, B., Calkhoven, C.F. and Leutz, A.
Genes & Development 24 (1): 15-20. 1 January 2010

2009

The dangers of transcription.
Mathas, S. and Misteli, T.
Cell 139 (6): 1047-1049. 11 December 2009

Identification of a chemokine receptor profile characteristic for mediastinal large B-cell lymphoma.
Rehm, A., Anagnostopoulos, I., Gerlach, K., Broemer, M., Scheidereit, C., Joehrens, K., Huebler, M., Hetzer, R., Stein, H., Lipp, M., Doerken, B. and Höpken, U.E.
International Journal of Cancer 125 (10): 2367-2374. 15 November 2009

Severe thrombocytopenia in a patient with metastatic renal cell carcinoma.
Floercken, A., Loew, A., Koch, M., Gebauer, B., Doerken, B. and Riess, H.
Onkologie 32 (11): 670-672. November 2009

C/EBPβ regulates transcription factors critical for proliferation and survival of multiple myeloma cells.
Pal, R., Janz, M., Galson, D.L., Gries, M., Li, S., Johrens, K., Anagnostopoulos, I., Doerken, B., Mapara, M.Y., Borghesi, L., Kardava, L., Roodman, G.D., Milcarek, C. and Lentzsch, S.
Blood 114 (18): 3890-3898. 29 October 2009

Treatment of PTLD with rituximab and CHOP reduces the risk of renal graft impairment after reduction of immunosuppression.
Trappe, R., Hinrichs, C., Appel, U., Babel, N., Reinke, P., Neumayer, H.H., Budde, K., Dreyling, M., Duehrsen, U., Kliem, V., Schuettrumpf, S., Hauser, I.A., Mergenthaler, H.G., Schlattmann, P., Anagnostopoulos, I., Doerken, B. and Riess, H.
American Journal of Transplantation 9 (10): 2331-2337. October 2009

Escalated-dose BEACOPP in the treatment of patients with advanced-stage Hodgkin's lymphoma: 10 years of follow-up of the GHSG HD9 study.
Engert, A., Diehl, V., Franklin, J., Lohri, A., Doerken, B., Ludwig, W.D., Koch, P., Haenel, M., Pfreundschuh, M., Wilhelm, M., Truemper, L., Aulitzky, W.E., Bentz, M., Rummel, M., Sezer, O., Mueller-Hermelink, H.K., Hasenclever, D. and Loeffler, M.
Journal of Clinical Oncology 27 (27): 4548-4554. 20 September 2009

Die molekulare Pathogenese des klassischen Hodgkin-Lymphoms [The molecular pathogenesis of classical Hodgkin lymphoma].
Mathas, S., Doerken, B. and Janz, M.
Deutsche Medizinische Wochenschrift 134 (39): 1944-1948. September 2009

The tumor-associated antigen EBAG9 negatively regulates the cytolytic capacity of mouse CD8+ T cells.
Rueder, C., Höpken, U.E., Wolf, J., Mittruecker, H.W., Engels, B., Erdmann, B., Wollenzin, S., Uckert, W., Dörken, B. and Rehm, A.
Journal of Clinical Investigation 119 (8): 2184-2203. August 2009

Reactivation of hepatitis E infection in a patient with acute lymphoblastic leukaemia after allogeneic stem cell transplantation.
le Coutre, P., Meisel, H., Hofmann, J., Roecken, C., Vuong, G.L., Neuburger, S., Hemmati, P.G., Doerken, B. and Arnold, R.
Gut 58 (5): 699-702. May 2009

Gene deregulation and spatial genome reorganization near breakpoints prior to formation of translocations in anaplastic large cell lymphoma.
Mathas, S., Kreher, S., Meaburn, K.J., Joehrens, K., Lamprecht, B., Assaf, C., Sterry, W., Kadin, M.E., Daibata, M., Joos, S., Hummel, M., Stein, H., Janz, M., Anagnostopoulos, I., Schrock, E., Misteli, T. and Doerken, B.
Proceedings of the National Academy of Sciences of the United States of America 106 (14): 5831-5836. 7 April 2009

Second-line therapy in refractory pancreatic cancer. results of a phase II study.
Pelzer, U., Stieler, J., Roll, L., Hilbig, A., Doerken, B., Riess, H. and Oettle, H.
Onkologie 32 (3): 99-102. March 2009

Use of Kaede fusions to visualize recycling of G protein-coupled receptors.
Schmidt, A., Wiesner, B., Weisshart, K., Schulz, K., Furkert, J., Lamprecht, B., Rosenthal, W. and Schuelein, R.
Traffic 10 (1): 2-15. January 2009

2008

Rationale and design of PROSPECT-CONKO 004: a prospective, randomized trial of simultaneous pancreatic cancer treatment with enoxaparin and chemotherapy.
Riess, H., Pelzer, U., Hilbig, A., Stieler, J., Opitz, B., Scholten, T., Kauschat-Bruning, D., Bramlage, P., Doerken, B. and Oettle, H.
BMC Cancer 8 (1): 361. 5 December 2008

Allogeneic SCT in refractory or relapsed adult ALL is effective without prior reinduction chemotherapy.
Terwey, T.H., Massenkeil, G., Tamm, I., Hemmati, P.G., Neuburger, S., Martus, P., Doerken, B., Hoelzer, D. and Arnold, R.
Bone Marrow Transplantation 42 (12): 791-798. December 2008

Notch inhibition blocks multiple myeloma cell-induced osteoclast activation.
Schwarzer, R., Kaiser, M., Acikgoez, O., Heider, U., Mathas, S., Preissner, R., Sezer, O., Doerken, B. and Jundt, F.
Leukemia 22 (12): 2273-2277. December 2008

Aberrant expression of the Th2 cytokine IL-21 in Hodgkin lymphoma cells regulates STAT3 signaling and attracts Treg cells via regulation of MIP-3α.
Lamprecht, B., Kreher, S., Anagnostopoulos, I., Joehrens, K., Monteleone, G., Jundt, F., Stein, H., Janz, M., Doerken, B. and Mathas, S.
Blood 112 (8): 3339-3347. 15 October 2008

The pathogenesis of classical Hodgkin's lymphoma: what can we learn from analyses of genomic alterations in Hodgkin and Reed-Sternberg cells?
Janz, M. and Mathas, S.
Haematologica 93 (9): 1292-1295. September 2008

Aberrant expression of Notch1 interferes with the B-lymphoid phenotype of neoplastic B cells in classical Hodgkin lymphoma.
Jundt, F., Acikgoez, O., Kwon, S.H., Schwarzer, R., Anagnostopoulos, I., Wiesner, B., Mathas, S., Hummel, M., Stein, H., Reichardt, H.M. and Doerken, B.
Leukemia 22 (8): 1587-1594. August 2008

IkappaBalpha is required for marginal zone B cell lineage development.
Ellinghaus, U., Rupec, R.A., Pabst, O., Ignatius, R., Foerster, R., Doerken, B. and Jundt, F.
European Journal of Immunology 38 (8): 2096-2105. August 2008

Successful salvage treatment of disseminated cutaneous fusariosis with liposomal amphotericin B and terbinafine after allogeneic stem cell transplantation.
Neuburger, S., Massenkeil, G., Seibold, M., Lutz, C., TammI, I., Le Coutre, P., Graf, B., Doerken, B. and Arnold, R.
Transplant Infectious Disease 10 (4): 290-293. August 2008

Epigenetic and genetic analysis of the survivin promoter in acute myeloid leukemia.
Wagner, M., Schmelz, K., Doerken, B. and Tamm, I.
Leukemia Research 32 (7): 1054-1060. July 2008

A pilot study of prophylactic donor lymphocyte infusions to prevent relapse in adult acute lymphoblastic leukemias after allogeneic hematopoietic stem cell transplantation.
Lutz, C., Massenkeil, G., Nagy, M., Neuburger, S., Tamm, I., Rosen, O., Doerken, B. and Arnold, R.
Bone Marrow Transplantation 41 (9): 805-812. May 2008

Transcriptional regulation of human survivin by early growth response (Egr)-1 transcription factor.
Wagner, M., Schmelz, K., Doerken, B. and Tamm, I.
International Journal of Cancer 122 (6): 1278-1287. 15 March 2008

Notch signaling in leukemias and lymphomas.
Jundt, F., Schwarzer, R. and Doerken, B.
Current Molecular Medicine 8 (1): 51-59. February 2008

2007

Salvage therapy for relapsed posttransplant lymphoproliferative disorders (PTLD) with a second progression of PTLD after upfront chemotherapy: the role of single-agent rituximab.
Trappe, R.U., Choquet, S., Reinke, P., Dreyling, M., Mergenthaler, H.G., Jaeger, U., Kebelmann-Betzing, C., Jonas, S., Lehmkuhl, H., Anagnostopoulos, I., Leblond, V., Hetzer, R., Doerken, B., Riess, H. and Oertel, S.
Transplantation 84 (12): 1708-1712. 27 December 2007

The Myc-evoked DNA damage response accounts for treatment resistance in primary lymphomas in vivo.
Reimann, M., Loddenkemper, C., Rudolph, C., Schildhauer, I., Teichmann, B., Stein, H., Schlegelberger, B., Doerken, B. and Schmitt, C.A.
Blood 110 (8): 2996-3004. 15 October 2007

The UT-A1 urea transporter interacts with snapin, a SNARE-associated protein.
Mistry, A.C., Mallick, R., Froehlich, O., Klein, J.D., Rehm, A., Chen, G. and Sands, J.M.
Journal of Biological Chemistry 282 (41): 30097-30106. 12 October 2007

In vivo splenic CD11c cells downregulate CD4 T-cell response thereby decreasing systemic immunity to gene-modified tumour cell vaccine.
Cayeux, S., Bukarica, B., Buschow, C., Charo, J., Bunse, M., Doerken, B. and Blankenstein, T.
Gene Therapy 14 (20): 1481-1491. October 2007

The pathogenesis of classical Hodgkin's lymphoma: a model for B-cell plasticity.
Mathas, S.
Hematology Oncology Clinics of North America 21 (5): 787-804. October 2007

Rituximab in the management of post-transplantation lymphoproliferative disorder after solid organ transplantation: proceed with caution.
Choquet, S., Oertel, S., Leblond, V., Riess, H., Varoqueaux, N., Doerken, B. and Trappe, R.
Annals of Hematology 86 (8): 599-607. August 2007

Intraoperative fresh-frozen plasma versus human albumin in craniofacial surgery - a pilot study comparing coagulation profiles in infants younger than 12 months.
Hildebrandt, B., Machotta, A., Riess, H., Kerner, S., Ahlers, O., Haberl, H., Doerken, B. and Kerner, T.
Thrombosis and Haemostasis 98 (1): 172-7. July 2007

Loss of bHLH transcription factor E2A activity in primary effusion lymphoma confers resistance to apoptosis.
Lietz, A., Janz, M., Sigvardsson, M., Jundt, F., Doerken, B. and Mathas, S.
British Journal of Haematology 137 (4): 342-348. May 2007

Interventionally implanted port catheter systems for hepatic arterial infusion of chemotherapy in patients with colorectal liver metastases: A phase II-study and historical comparison with the surgical approach.
Hildebrandt, B., Pech, M., Nicolaou, A., Langrehr, J.M., Kurcz, J., Bartels, B., Miersch, A., Felix, R., Neuhaus, P., Riess, H., Doerken, B. and Ricke, J.
BMC Cancer 7 : 69. 24 April 2007

Salvage chemotherapy for refractory and relapsed posttransplant lymphoproliferative disorders (PTLD) after treatment with single-agent rituximab.
Trappe, R., Riess, H., Babel, N., Hummel, M., Lehmkuhl, H., Jonas, S., Anagnostopoulos, I., Papp-Vary, M., Reinke, P., Hetzer, R., Doerken, B. and Oertel, S.
Transplantation 83 (7): 912-918. 15 April 2007

Pharmacologic activation of p53-dependent and p53-independent apoptotic pathways in Hodgkin/Reed-Sternberg cells.
Janz, M., Stuehmer, T., Vassilev, L.T. and Bargou, R.C.
Leukemia 21 (4): 772-779. April 2007

Dendritic cell maturation stage determines susceptibility to the proteasome inhibitor bortezomib.
Subklewe, M., Sebelin-Wulf, K., Beier, C., Lietz, A., Mathas, S., Doerken, B. and Pezzutto, A.
Human Immunology 68 (3): 147-155. March 2007

CCR7 deficiency causes ectopic lymphoid neogenesis and disturbed mucosal tissue integrity.
Höpken, U.E., Wengner, A.M., Loddenkemper, C., Stein, H., Heimesaat, M.M., Rehm, A. and Lipp, M.
Blood 109 (3): 886-895. 1 February 2007

Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: a randomized controlled trial.
Oettle, H., Post, S., Neuhaus, P., Gellert, K., Langrehr, J., Ridwelski, K., Schramm, H., Fahlke, J., Zuelke, C., Burkart, C., Gutberlet, K., Kettner, E., Schmalenberg, H., Weigang-Koehler, K., Bechstein, W.O., Niedergethmann, M., Schmidt-Wolf, I., Roll, L., Doerken, B. and Riess, H.
JAMA: Journal of the American Medical Association 297 (3): 267-277. 17 January 2007

STAT3 and MAPK signaling maintains overexpression of the heat shock proteins 90a and b in multiple myeloma cells, which critically contribute to tumor cell survival.
Chatterjee, M., Jain, S., Stuehmer, T., Andrulis, M., Ungethuem, U., Kuban, R.J., Lorentz, H., Bommert, K., Topp, M., Kramer, D., Mueller-Hermelink, H. K., Einsele, H., Greiner, A. and Bargou, R.C.
Blood 109 (2): 720-728. 15 January 2007

Initial chemotherapy with mitoxantrone, chlorambucil, prednisone impairs the collection of stem cells in patients with indolent lymphomas--results of a randomized comparison by the German Low-Grade Lymphoma Study Group.
Nickenig, C., Dreyling, M., Hoster, E., Ludwig, W.D., Doerken, B., Freund, M., Huber, C., Ganser, A., Truemper, L., Forstpointner, R., Unterhalt, M. and Hiddemann, W.
Annals of Oncology 18 (1): 136-142. January 2007

2006

Author reply: Polyclonal resistance in gastrointestinal stromal tumor treated with sequential kinase inhibitors.
Wardelmann, E., Biermann, K., Merkelbach-Bruse, S., Thomas, N., Schildhaus, H.U., Heinicke, T., Speidel, N., Pietsch, T., Buettner, R., Pink, D., Reichardt, P. and Hohenberger, P.
Clinical Cancer Research 12 (20): 6206-6207. 15 October 2006

In vivo expression of survivin and its splice variant survivin-2B: Impact on clinical outcome in acute myeloid leukemia.
Wagner, M., Schmelz, K., Wuchter, C., Ludwig, W.D., Doerken, B. and Tamm, I.
International Journal of Cancer 119 : 1291-1297. 15 September 2006

Adjuvant chemotherapy with folinic acid and 5-fluorouracil in patients with locally advanced rectal cancer previously treated by preoperative radiochemotherapy and curative tumor resection.
Hildebrandt, B., Rau, B., Loeffel, J., Wust, P., Nicolaou, A., Gellermann, J., Le Coutre, P., Neuhaus, P., Felix, R., Wernecke, K.D., Doerken, B. and Riess, H.
International Journal of Colorectal Disease 21 (6): 582-589. September 2006

Long-lasting remission of pulmonary metastases of renal cell cancer under IFN-beta therapy in a patient with multiple sclerosis.
Floercken, A., Denecke, T., Kretzschmar, A., Gollasch, H., Reich, G. and Westermann, J.
Onkologie 29 : 382-384. September 2006

Untersuchungen zur Molekularpathologie des Hodgkin-Lymphoms - Klonierung des I kappa B epsilon Gens und Mutationsanalyse in Einzelzellen.
Theurich, S.
UNSPECIFIED thesis, UNSPECIFIED. 24 July 2006

Chromosomal rearrangements involving the BCL3 locus are recurrent in classical Hodgkin and peripheral T-cell lymphoma.
Martin-Subero, J.I., Wlodarska, I., Bastard, C., Picquenot, J.M., Hoeppner, J., Giefing, M., Klapper, W., Siebert, R., Mathas, S., Joos, S., Stein, H. and Doerken, B.
Blood 108 : 401-403. 1 July 2006

Epstein-Barr viral load in whole blood of adults with posttransplant lymphoproliferative disorder after solid organ transplantation does not correlate with clinical course.
Oertel, S., Trappe, R.U., Zeidler, K., Babel, N., Reinke, P., Hummel, M., Jonas, S., Papp-Vary, M., Subklewe, M., Doerken, B., Riess, H. and Gaertner, B.
Annals of Hematology 85 : 478-484. July 2006

Harm or benefit of hormonal treatment in metastatic low-grade endometrial stromal sarcoma: Single center experience with 10 cases and review of the literature.
Pink, D., Lindner, T., Mrozek, A., Kretzschmar, A., Thuss-Patience, P.C., Doerken, B. and Reichardt, P.
Gynecologic Oncology 101 : 464-469. June 2006

Reprogramming of B lymphoid cells in human lymphoma pathogenesis.
Janz, M., Doerken, B. and Mathas, S.
Cell Cycle 5 (10): 1057-1061. 15 May 2006

T-cell activation and B-cell depletion in chimpanzees treated with a bispecific anti-CD19/anti-CD3 single-chain antibody construct.
Schlereth, B., Quadt, C., Dreier, T., Kufer, P., Lorenczewski, G., Prang, N., Brandl, C., Lippold, S., Cobb, K., Brasky, K., Leo, E., Bargou, R., Murthy, K. and Baeuerle, P.A.
Cancer Immunology Immunotherapy 55 : 503-514. May 2006

Loss of the tissue-specific proapoptotic BH3-only protein Nbk/Bik is a unifying feature of renal cell carcinoma.
Sturm, I., Stephan, C., Gillissen, B., Siebert, R., Janz, M., Radetzki, S., Jung, K., Loening, S., Doerken, B. and Daniel, P.T.
Cell Death and Differentiation 13 : 619-627. April 2006

Classical Hodgkin lymphoma is characterized by high constitutive expression of activating transcription factor 3 (ATF3) which promotes viability of Hodgkin/Reed-Sternberg cells.
Janz, M., Hummel, M., Truss, M., Wollert-Wulf, B., Mathas, S., Joehrens, K., Hagemeier, C., Bommert, K., Stein, H., Doerken, B. and Bargou, R.C.
Blood 107 (6): 2536-2539. 15 March 2006

Polyclonal evolution of multiple secondary KIT mutations in gastrointestinal stromal tumors under treatment with imatinib mesylate.
Wardelmann, E., Merkelbach-Bruse, S., Pauls, K., Thomas, N., Schildhaus, H.U., Heinicke, T., Speidel, N., Pietsch, T., Buettner, R., Pink, D., Reichardt, P. and Hohenberger, P.
Clinical Cancer Research 12 : 1743-1749. 15 March 2006

Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma.
Mathas, S., Janz, M., Hummel, F., Hummel, M., Wollert-Wulf, B., Lusatis, S., Anagnostopoulos, I., Lietz, A., Sigvardsson, M., Jundt, F., Joehrens, K., Bommert, K., Stein, H. and Doerken, B.
Nature Immunology 7 (2): 207-215. February 2006

Successful treatment of thrombocytopenia in primary antiphospholipid antibody syndrome with the anti-CD20 antibody rituximab-monitoring of antiphospholipid and anti-GP antibodies: a case report.
Trappe, R., Loew, A., Thuss-Patience, P., Doerken, B. and Riess, H.
Annals of Hematology 85 : 134-135. February 2006

Four versus six courses of a dose-escalated cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) regimen plus etoposide (megaCHOEP) and autologous stem cell transplantation.
Schmitz, N., Kloess, M., Reiser, M., Berdel, W.E., Metzner, B., Doerken, B., Kneba, M., Trumper, L., Loeffler, M., Pfreundschuh, M. and Glass, B.
Cancer 106 : 136-145. 1 January 2006

Selective pharmacologic activation of the p53-dependent pathway as a therapeutic strategy for hematologic malignancies.
Stuehmer, T. and Bargou, R.C.
Cell Cycle 5 : 39-42. 1 January 2006

Leukemia.
Bargou, R. and Ludwig, W.D.
In: Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine ; Vol. 1. Springer, Berlin [u.a.], 967-974. ISBN 3-540-44244-8 2006

2005

Effect of anti-CD 20 antibody rituximab in patients with post-transplant lymphoproliferative disorder (PTLD).
Oertel, S.H., Verschuuren, E., Reinke, P., Zeidler, K., Papp-Vary, M., Babel, N., Trappe, R.U., Jonas, S., Hummel, M., Anagnostopoulos, I., Doerken, B. and Riess, H.B.
American Journal of Transplantation 5 : 2901-2906. 1 December 2005

CD52 is not a promising immunotherapy target for most patients with multiple myeloma.
Westermann, J., Maschmeyer, G., Lessen, A., Doerken, B. and Pezzutto, A.
International Journal of Hematology 82 : 248-250. 1 October 2005

The ratio between dendritic cells and T cells determines the outcome of their encounter: Proliferation versus deletion.
Höpken, U.E., Lehmann, I., Droese, J., Lipp, M., Schueler, T. and Rehm, A.
European Journal of Immunology 35 (10): 2851-2863. 23 September 2005

Elevated NF-kappaB p50 complex formation and Bcl-3 expression in classical Hodgkin, anaplastic large cell, and other peripheral T-cell lymphomas.
Mathas, S., Joehrens, K., Joos, S., Lietz, A., Hummel, F., Janz, M., Jundt, F., Anagnostopoulos, I., Bommert, K., Lichter, P., Stein, H., Scheidereit, C. and Doerken, B.
Blood 106 (13): 4287-4293. 25 August 2005

Survival after reduced-intensity conditioning is not inferior to standard high-dose conditioning before allogeneic haematopoietic cell transplantation in acute leukaemias.
Massenkeil, G., Nagy, M., Neuburger, S., Tamm, I., Lutz, C., Le Coutre, P., Rosen, O., Wernecke, K.D., Doerken, B. and Arnold, R.
Bone Marrow Transplantation 36 : 683-689. 22 August 2005

In B-CLL, the codon 72 polymorphic variants of p53 are not related to drug resistance and disease prognosis.
Sturm, I., Bosanquet, A.G., Hummel, M., Doerken, B. and Daniel, P.T.
BMC Cancer 5 : 105. 18 August 2005

Non-genotoxic activation of the p53 pathway as a therapeutic strategy for multiple myeloma.
Stuehmer, T., Chatterjee, M., Hildebrandt, M., Herrmann, P., Gollasch, H., Gerecke, C., Theurich, S., Cigliano, L., Manz, R.A., Daniel, P.T., Bommert, K., Vassilev, L.T. and Bargou, R.C.
Blood 106 : 3609-3617. 4 August 2005

Oncogene-induced senescence as an initial barrier in lymphoma development.
Braig, M., Lee, S., Loddenkemper, C., Rudolph, C., Peters, A.H., Schlegelberger, B., Stein, H., Doerken, B., Jenuwein, T. and Schmitt, C.A.
Nature 436 (7051): 660-665. 4 August 2005

Prognostic value of multimarker analysis in stage III colorectal cancer: one step forward towards an individualized therapy decision.
Grabowski, P., Maaser, K., Hanski, C., Stein, H., Sturm, I., Hopfenmueller, W., Doerken, B., Buhr, H.J., Zeitz, M. and Scheruebl, H.
Onkologie 28 (8-9): 399-403. 1 August 2005

Grundlagen der molekularen Diagnostik und Therapie maligner Tumoren [Basics of molecular diagnostics and therapy of malignant tumors].
Daniel, P.T. and Doerken, B.
Internist 46 (8): 835-846. 12 July 2005

Empirical antimicrobial monotherapy in patients after high-dose chemotherapy and autologous stem cell transplantation: a randomised, multicentre trial.
Reich, G., Cornely, O.A., Sandherr, M., Kubin, T., Krause, S., Einsele, H., Thiel, E., Bellaire, T., Doerken, B. and Maschmeyer, G.
British Journal of Haematology 130 : 265-270. 1 July 2005

YB-1 provokes breast cancer through the induction of chromosomal instability that emerges from mitotic failure and centrosome amplification.
Bergmann, S., Royer-Pokora, B., Fietze, E., Juerchott, K., Hildebrandt, B., Trost, D., Leenders, F., Claude, J.C., Theuring, F., Bargou, R., Dietel, M. and Royer, H.D.
Cancer Research 65 (10): 4078-4087. 16 May 2005

5-Aza-2'-deoxycytidine induces p21WAF expression by demethylation of p73 leading to p53-independent apoptosis in myeloid leukemia.
Schmelz, K., Wagner, M., Doerken, B. and Tamm, I.
International Journal of Cancer 114 : 683-695. 1 May 2005

Imatinib mesylate radiosensitizes human glioblastoma cells through inhibition of platelet-derived growth factor receptor.
Holdhoff, M., Kreuzer, K.A., Appelt, C., Scholz, R., Na, I.K., Hildebrandt, B., Riess, H., Jordan, A., Schmidt, C.A., Van Etten, R.A., Doerken, B. and LeCoutre, P.
Blood Cells Molecules and Diseases 34 (2): 181-185. 1 March 2005

EBAG9 adds a new layer of control on large dense-core vesicle exocytosis via interaction with Snapin.
Rueder, C., Reimer, T., Delgado-Martinez, I., Hermosilla, R., Engelsberg, A., Nehring, R., Doerken, B. and Rehm, A.
Molecular Biology of the Cell 16 (3): 1245-1257. 5 January 2005

A rapamycin derivative (everolimus) controls proliferation through down-regulation of truncated CCAAT enhancer binding protein beta and NF-kappaB activity in Hodgkin and anaplastic large cell lymphomas.
Jundt, F., Raetzel, N., Mueller, C., Calkhoven, C.F., Kley, K., Mathas, S., Lietz, A., Leutz, A. and Doerken, B.
Blood 106 : 1801-1807. 1 January 2005

Cologne high-dose sequential chemotherapy in relapsed and refractory Hodgkin lymphoma: results of a large multicenter study of the German Hodgkin Lymphoma Study Group (GHSG).
Josting, A., Rudolph, C., Mapara, M., Glossmann, J.P., Sieniawski, M., Sieber, M., Kirchner, H.H., Doerken, B., Hossfeld, D.K., Kisro, J., Metzner, B., Berdel, W.E., Diehl, V. and Engert, A.
Annals of Oncology 16 : 116-123. 1 January 2005

Distinction of acute lymphoblastic leukemia from acute myeloid leukemia through microarray-based DNA methylation analysis.
Scholz, C., Nimmrich, I., Burger, M., Becker, E., Doerken, B., Ludwig, W.D. and Maier, S.
Annals of Hematology 84 : 236-244. 1 January 2005

Docetaxel and continuous-infusion fluorouracil versus epirubicin, cisplatin, and fluorouracil for advanced gastric adenocarcinoma: a randomized phase II study.
Thuss-Patience, P.C., Kretzschmar, A., Repp, M., Kingreen, D., Hennesser, D., Micheel, S., Pink, D., Scholz, C., Doerken, B. and Reichardt, P.
Journal of Clinical Oncology 23 : 494-501. 1 January 2005

Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin.
Ding, Q., Xia, W., Liu, J.C., Yang, J.Y., Lee, D.F., Xia, J., Bartholomeusz, G., Li, Y., Pan, Y., Li, Z., Bargou, R.C., Qin, J., Lai, C.C., Tsai, F.J., Tsai, C.H. and Hung, M.C.
Molecular Cell 19 : 159-170. 1 January 2005

High-dose sequential chemotherapy followed by autologous stem cell transplantation in relapsed and refractory aggressive non-Hodgkin's lymphoma: results of a multicenter phase II study.
Josting, A., Sieniawski, M., Glossmann, J.P., Staak, O., Nogova, L., Peters, N., Mapara, M., Doerken, B., Ko, Y., Metzner, B., Kisro, J., Diehl, V. and Engert, A.
Annals of Oncology 16 : 1359-1365. 1 January 2005

Immunomodulatory derivative of thalidomide (IMiD CC-4047) induces a shift in lineage commitment by suppressing erythropoiesis and promoting myelopoiesis.
Koh, K.R., Janz, M., Mapara, M.Y., Lemke, B., Stirling, D., Doerken, B., Zenke, M. and Lentzsch, S.
Blood 105 (10): 3833-3840. 1 January 2005

Induction of gene expression by 5-Aza-2'-deoxycytidine in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) but not epithelial cells by DNA-methylation-dependent and -independent mechanisms.
Schmelz, K., Sattler, N., Wagner, M., Luebbert, M., Doerken, B. and Tamm, I.
Leukemia 19 : 103-111. 1 January 2005

Reevaluation of the 22-1-1 antibody and its putative antigen, EBAG9/RCAS1, as a tumor marker.
Reimer, T.A., Anagnostopoulos, I., Erdmann, B., Lehmann, I., Stein, H., Daniel, P., Doerken, B. and Rehm, A.
BMC Cancer 5 (1): 47. 1 January 2005

Serial killing of tumor cells by cytotoxic T cells redirected with a CD19-/CD3-bispecific single-chain antibody construct.
Hoffmann, P., Hofmeister, R., Brischwein, K., Brandl, C., Crommer, S., Bargou, R., Itin, C., Prang, N. and Baeuerle, P.A.
International Journal of Cancer 115 : 98-104. 1 January 2005

Stroma-mediated dysregulation of myelopoiesis in mice lacking IkappaBalpha.
Rupec, R.A., Jundt, F., Rebholz, B., Eckelt, B., Weindl, G.N., Herzinger, T., Flaig, M.J., Moosmann, S., Plewig, G., Doerken, B., Foerster, I., Huss, R. and Pfeffer, K.
Immunity 22 : 479-491. 1 January 2005

2004

HCMV-encoded chemokine receptor US28 employs multiple routes for internalization.
Droese, J., Mokros, T., Hermosilla, R., Schuelein, R., Lipp, M., Höpken, U.E. and Rehm, A.
Biochemical and Biophysical Research Communications 322 (1): 42-49. 10 September 2004

Nonmyeloablative stem cell transplantation in metastatic renal cell carcinoma: delayed graft-versus-tumor effect is associated with chimerism conversion but transplantation has high toxicity.
Massenkeil, G., Roigas, J., Nagy, M., Wille, A., Stroszczynski, C., Mapara, M.Y., Loening, S., Doerken, B. and Arnold, R.
Bone Marrow Transplantation 34 (4): 309-316. 1 August 2004

Characterization of apoptosis-induced Mcm3 and Cdc6 cleavage reveals a proapoptotic effect for one Mcm3 fragment.
Schories, B., Engel, K., Doerken, B., Gossen, M. and Bommert, K.
Cell Death and Differentiation 11 (8): 940-942. August 2004

Trimethoprim-sulfamethoxazole exacerbates posthypoxic action myoclonus in a patient with suspicion of Pneumocystis jiroveci infection.
Jundt, F., Lempert, T., Doerken, B. and Pezzutto, A.
Infection 32 (3): 176-178. 1 June 2004

c-FLIP mediates resistance of Hodgkin/Reed-Sternberg cells to death receptor-induced apoptosis.
Mathas, S., Lietz, A., Anagnostopoulos, I., Hummel, F., Wiesner, B., Janz, M., Jundt, F., Hirsch, B., Joehrens-Leder, K., Vornlocher, H.P., Bommert, K., Stein, H. and Doerken, B.
Journal of Experimental Medicine 199 (8): 1041-1052. 19 April 2004

Pharmacokinetics and cellular uptake of imatinib and its main metabolite CGP74588.
Le Coutre, P., Kreuzer, K.A., Pursche, S., Bonin, M., Leopold, T., Baskaynak, G., Doerken, B., Ehninger, G., Ottmann, O., Jenke, A., Bornhaeuser, M. and Schleyer, E.
Cancer Chemotherapy and Pharmacology 53 (4): 313-323. 1 April 2004

A novel recombinant bispecific single-chain antibody, bscWue-1 x CD3, induces T-cell-mediated cytotoxicity towards human multiple myeloma cells.
Hoenemann, D., Kufer, P., Rimpler, M.M., Chatterjee, M., Friedl, S., Riecher, F., Bommert, K., Doerken, B. and Bargou, R.C.
Leukemia 18 (3): 636-644. 1 January 2004

Combined disruption of both the MEK/ERK and the IL-6R/STAT3 pathways is required to induce apoptosis of multiple myeloma cells in the presence of bone marrow stromal cells.
Chatterjee, M., Stuehmer, T., Herrmann, P., Bommert, K., Doerken, B. and Bargou, R.C.
Blood 104 (12): 3712-3721. 1 January 2004

Differential Emu enhancer activity and expression of BOB.1/OBF.1, Oct2, PU.1, and immunoglobulin in reactive B-cell populations, B-cell non-Hodgkin lymphomas, and Hodgkin lymphomas.
Loddenkemper, C., Anagnostopoulos, L., Hummel, M., Joehrens-Leder, K., Foss, H.D., Jundt, F., Wirth, T., Doerken, B. and Stein, H.
Journal of Pathology 202 (5): 60-69. 1 January 2004

Downregulation of genes involved in DNA repair and differential expression of transcription regulators and phosphatases precede IgM-induced apoptosis in the Burkitt's lymphoma cell line BL60-2.
Schories, B., Janz, M., Doerken, B. and Bommert, K.
Biochimica et Biophysica Acta - Gene Structure and Expression 1676 (1): 83-95. 1 January 2004

Effective use of high-dose chemotherapy and autologous stem cell rescue for relapsed adult Wilms' tumor and a novel alteration in intron 1 of the WT1 gene.
Trappe, R.U., Riess, H., Lippek, F., Plotkin, M., Schumacher, V., Royer-Pokora, B., Hildebrandt, B., Zuber, J., Mapara, M.Y., Oertel, S. and Doerken, B.
Journal of Pediatric Hematology Oncology 26 : 820-823. 1 January 2004

Filgrastim-induced stem cell mobilization in chronic myeloid leukaemia patients during imatinib therapy: safety, feasibility and evidence for an efficient in vivo purging.
Kreuzer, K.A., Kluehs, C., Baskaynak, G., Movassaghi, K., Doerken, B. and Le Coutre, P.
British Journal of Haematology 124 (2): 195-199. 1 January 2004

Jagged1-induced notch signaling drives proliferation of multiple myeloma cells.
Jundt, F., Schulze-Proebsting, K., Anagnostopoulos, I., Muehlinghaus, G., Chatterjee, M., Mathas, S., Bargou, R.C., Manz, R., Stein, H. and Doerken, B.
Blood 103 (9): 3511-3515. 1 January 2004

Nonmyeloablative stem cell transplantation in patients with ALL and AML results in low nonrelapse mortality despite high rate of infections and GVHD.
Massenkeil, G., Nagy, M., Le Coutre, P., Heine, F., Rosen, O., Doerken, B. and Arnold, R.
Hematology Journal 5 (5): 395-402. 1 January 2004

PI3-K/AKT/FKHR and MAPK signaling cascades are redundantly stimulated by a variety of cytokines and contribute independently to proliferation and survival of multiple myeloma cells.
Lentzsch, S., Chatterjee, M., Gries, M., Bommert, K., Gollasch, H., Doerken, B. and Bargou, R.C.
Leukemia 18 (11): 1883-1890. 1 January 2004

Panhypopituitarism in a patient with breast cancer.
Sturm, I., Kirschke, S., Krahl, D. and Doerken, B.
Onkologie 27 : 480-482. 1 January 2004

T-cell-mediated lysis of B cells induced by a CD19xCD3 bispecific single-chain antibody is perforin dependent and death receptor independent.
Gruen, M., Bommert, K. and Bargou, R.C.
Cancer Immunology Immunotherapy 53 (7): 625-632. 1 January 2004

Cellular senescence in cancer treatment: friend or foe?
Kahlem, P., Doerken, B. and Schmitt, C.A.
Journal of Clinical Investigation 113 (2): 169-174. January 2004

2003

6-Thioguanine, cytarabine, and daunorubicin (TAD) and high-dose cytarabine and mitoxantrone (HAM) for induction, TAD for consolidation, and either prolonged maintenance by reduced monthly TAD or TAD-HAM-TAD and one course of intensive consolidation by sequential HAM in adult patients at all ages with de novo acute myeloid leukemia (AML): a randomized trial of the German AML Cooperative Group.
Buechner, T., Hiddemann, W., Berdel, W.E., Woermann, B., Schoch, C., Fonatsch, C., Loeffler, H., Haferlach, T., Ludwig, W.D., Maschmeyer, G., Staib, P., Aul, C., Grueneisen, A., Lengfelder, E., Frickhofen, N., Kern, W., Serve, H.L., Mesters, R.M., Sauerland, M.C. and Heinecke, A.
Journal of Clinical Oncology 21 : 4496-4504. 15 December 2003

Clinical research and industrial sponsoring: avenues towards transparency and credibility.
Hildebrandt, M. and Ludwig, W.D.
Onkologie 26 : 529-534. 1 December 2003

The prognostic significance of antigen expression in leukaemia.
Schabath, R., Ratei, R. and Ludwig, W.D.
Best Practice & Research in Clinical Haematology 16 : 613-628. 1 December 2003

An open label, non-comparative phase II study of topotecan as salvage treatment for patients with soft tissue sarcoma.
Reichardt, P., Oechsle, K., Pink, D., Bokemeyer, C., Schneller, F., Issels, R., Kanz, L. and Hartmann, J.T.
Investigational New Drugs 21 : 481-486. 1 November 2003

Extravasations of oxaliplatin.
Kretzschmar, A., Pink, D., Thuss-Patience, P., Doerken, B., Reichert, P. and Eckert, R.
Journal of Clinical Oncology 21 (21): 4068-4069. 1 November 2003

Inactivating I kappa B epsilon mutations in Hodgkin/Reed-Sternberg cells.
Emmerich, F., Theurich, S., Hummel, M., Haeffker, A., Vry, M.S., Doehner, K., Bommert, K., Stein, H. and Doerken, B.
Journal of Pathology 201 (3): 413-420. November 2003

Dynamic expression profile of p21 WAF1/CIP1 and Ki-67 predicts survival in rectal carcinoma treated with preoperative radiochemotherapy.
Rau, B., Sturm, I., Lage, H., Berger, S., Schneider, U., Haupfmann, S., Wust, P., Riess, H., Schlag, P.M., Doerken, B. and Daniel, P.T.
Journal of Clinical Oncology 21 (18): 3391-3401. 15 September 2003

Correlation of protein expression and gene expression in acute leukemia.
Kern, W., Kohlmann, A., Wuchter, C., Schnittger, S., Schoch, C., Mergenthaler, S., Ratei, R., Ludwig, W.D., Hiddemann, W. and Haferlach, T.
Cytometry 55B : 29-36. 1 September 2003

Disruption of cell death signaling in cancer: impact on disease prognosis and response to therapy.
Guener, D., Belka, C. and Daniel, P.T.
Current Medicinal Chemistry Anti-Cancer Agents 3 (5): 319-326. 1 September 2003

Need for safety goggles for endoscopy.
Benter, T., Kluehs, L., Teichgraeber, U.K.M., Riechert, F., Ludwig, W.D. and Doerken, B.
Endoscopy 35 (9): 803. 1 September 2003

Inhibition of NF-κB essentially contributes to arsenic-induced apoptosis.
Mathas, S., Lietz, A., Janz, M., Hinz, M., Jundt, F., Scheidereit, C., Bommert, K. and Doerken, B.
Blood 102 (3): 1028-1034. 1 August 2003

Oxaliplatin and 5-fluorouracil for heavily pretreated metastatic breast cancer: a preliminary phase II study.
Thuss-Patience, P.C., von Minckwitz, G., Kretzschmar, A., Loibl, S., Schaller, G., Doerken, B. and Reichardt, P.
Anti-Cancer Drugs 14 (7): 549-553. 1 August 2003

Recombinant human erythropoietin, epoetin beta, in patients with relapsed lymphoma treated with aggressive sequential salvage chemotherapy - results of a randomized trial.
Glossmann, J.P., Engert, A., Wassmer, G., Flechtner, H., Ko, Y., Rudolph, C., Metzner, B., Doerken, B., Wiedenmann, S., Diehl, V. and Josting, A.
Annals of Hematology 82 (8): 469-475. 1 August 2003

Donor lymphocyte infusion-mediated graft-versus-leukemia effects in mixed chimeras established with a nonmyeloablative conditioning regimen: extinction of graft-versus-leukemia effects after conversion to full donor chimerism.
Mapara, M.Y., Kim, Y.M., Marx, J. and Sykes, M.
Transplantation 76 : 297-305. 27 July 2003

Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway.
Gillissen, B., Essmann, F., Graupner, V., Staerck, L., Radetzki, S., Doerken, B., Schulze-Osthoff, K. and Daniel, P.T.
EMBO Journal 22 (14): 3580-3590. 15 July 2003

Central venous access catheters: radiological management of complications.
Teichgraeber, U.K., Gebauer, B., Benter, T. and Wagner, H.J.
Cardiovascular and Interventional Radiology 26 : 321-333. 1 July 2003

Chemotherapy in alveolar soft part sarcomas: What do we know?
Reichardt, P., Lindner, T., Pink, D., Thuss-Patience, P.C., Kretzschmar, A. and Doerken, B.
European Journal of Cancer 39 (11): 1511-1516. 1 July 2003

Standard and increased-dose BEACOPP chemotherapy compared with COPP-ABVD for advanced Hodgkins disease.
Diehl, V., Franklin, J., Pfreundschuh, M., Lathan, B., Paulus, U., Hasenclever, D., Tesch, H., Herrmann, R., Doerken, B., Mueller-Hermelink, H.K., Duehmke, E. and Loeffler, M.
New England Journal of Medicine 348 (24): 2386-2395. 12 June 2003

CT-gesteuerte bronchoskopische Punktion zur Diagnosesicherung einer hilaeren Raumforderung [CT-controlled bronchoscopic puncture in diagnostic verification of hilar space occupying lesion].
Teichgraeber, U.K., Gebauer, B. and Benter, T.
RoeFo Fortschritte auf dem Gebiete der Roentgenstrahlen und der neuen bildgebenden Verfahren 175 : 857-858. 1 June 2003

Detection of minimal residual disease in unselected patients with acute myeloid leukemia using multiparameter flow cytometry for definition of leukemia-associated immunophenotypes and determination of their frequencies in normal bone marrow.
Kern, W., Danhauser-Riedl, S., Ratei, R., Schnittger, S., Schoch, C., Kolb, H.J., Ludwig, W.D., Hiddemann, W. and Haferlach, T.
Haematologica 88 : 646-653. 1 June 2003

Morphologie gastrointestinaler Stromatumoren im fortgeschrittenen Stadium der Erkrankung: Ausgangsbefunde vor Chemotherapie mit Imatinib [Morphology of gastrointestinal stromal tumors in advanced stages of the disease: baseline findings before chemotherapy with imatinib].
Jost, D., Stroszczynski, C., Chmelik, P., Gaffke, G., Schlecht, I., Pink, D., Reichardt, P., Schneider, U., Hohenberger, P. and Felix, R.
RoeFo Fortschritte auf dem Gebiete der Roentgenstrahlen und der neuen bildgebenden Verfahren 175 : 791-798. 1 June 2003

Acute hypokalemic tetraparesis induced by intravenous methotrexate.
Thuss-Patience, P.C., Peters, U., Jurkat-Rott, K., Pink, D., Kretzschmar, A., Doerken, B. and Reichardt, P.
Journal of Clinical Oncology 21 (9): 1896-1897. 1 May 2003

Macrophage inflammatory protein 1-alpha (MIP-1alpha) triggers migration and signaling cascades mediating survival and proliferation in multiple myeloma (MM) cells.
Lentzsch, S., Gries, M., Janz, M., Bargou, R., Doerken, B. and Mapara, M.Y.
Blood 101 (9): 3568-3573. 1 May 2003

Efficient elimination of chronic lymphocytic leukaemia B cells by autologous T cells with a bispecific anti-CD19/anti-CD3 single-chain antibody construct.
Loeffler, A., Gruen, M., Wuchter, C., Schriever, F., Kufer, P., Dreier, T., Hanakam, F., Baeuerle, P.A., Bommert, K., Karawajew, L., Doerken, B. and Bargou, R.C.
Leukemia 17 (5): 900-909. May 2003

Genauigkeit der sonographischen Milzgewichtsbestimmung am Lebenden im Vergleich zum pathologischen Korrelat [Accuracy of the sonographic determination of the splenic weight in comparison with the weight at autopsy].
Kluehs, L., Teichgraeber, U.K., Schneider, U., Ludwig, W.D., Doerken, B. and Benter, T.
RoeFo Fortschritte auf dem Gebiete der Roentgenstrahlen und der neuen bildgebenden Verfahren 175 (4): 532-535. 1 April 2003

Coexpression of p21WAF1/CIP1 in adenovirus vector transfected human primary hepatocytes prevents apoptosis resulting in improved transgene expression.
Wolff, G., Schumacher, A., Nuessler, A.K., Ruppert, V., Karawajew, L., Wehnes, E., Neuhaus, P. and Doerken, B.
Gene Therapy 10 (8): 668-677. April 2003

Synovialsarkome der Extremitaeten - Ergebnisse chirurgischer und multimodaler Therapie [Synovial sarcoma of the extremities. Results of surgical and multimodal therapy].
Ulmer, C., Kettelhack, C., Tunn, P.U., Reichardt, P., Hohenberger, P. and Schlag, P.M.
Chirurg 74 (4): 370-374. April 2003

Identification and quantification of in vitro adduct formation between protein reactive xenobiotics and a lysine-containing model peptide.
Reichardt, P., Schreiber, A., Wichmann, G., Metzner, G., Efer, J. and Raabe, F.
Environmental Toxicology 18 : 29-36. 1 February 2003

Recurrent gastric adenocarcinoma with unusual metastatic localization and excellent response to docetaxel and 5-FU continuous infusion.
Thuss-Patience, P.C., Kretzschmar, A., Krenn, V., Doerken, B. and Reichardt, P.
Onkologie 26 (1): 63-65. 1 February 2003

Chemotherapy response and resistance.
Lee, S. and Schmitt, C.A.
Current Opinion in Genetics & Development 13 (1): 90-96. February 2003

Identifikation Apoptose-assoziierter Gene in B-Zellen und Charakterisierung des Genproduktes LAPTM5.
Schneider, H.
UNSPECIFIED thesis, UNSPECIFIED. 16 January 2003

Morphologic dysplasia in de novo acute myeloid leukemia (AML) is related to unfavorable cytogenetics but has no independent prognostic relevance under the conditions of intensive induction therapy: results of a multiparameter analysis from the German AML Cooperative Group studies.
Haferlach, T., Schoch, C., Loeffler, H., Gassmann, W., Kern, W., Schnittger, S., Fonatsch, C., Ludwig, W.D., Wuchter, C., Schlegelberger, B., Staib, P., Reichle, A., Kubica, U., Eimermacher, H., Balleisen, L., Grueneisen, A., Haase, D., Aul, C., Karow, J., Lengfelder, E., Woermann, B., Heinecke, A., Sauerland, M.C., Buechner, T. and Hiddemann, W.
Journal of Clinical Oncology 21 : 256-265. 15 January 2003

Immunomodulatory analogs of thalidomide inhibit growth of Hs Sultan cells and angiogenesis in vivo.
Lentzsch, S., LeBlanc, R., Podar, K., Davies, F., Lin, B., Hideshima, T., Catley, L., Stirling, D.I. and Anderson, K.C.
Leukemia 17 : 41-44. 1 January 2003

The Golgi protein RCAS1 controls cell surface expression of tumor-associated O-linked glycan antigens.
Engelsberg, A., Hermosilla, R., Karsten, U., Schuelein, R., Doerken, B. and Rehm, A.
Journal of Biological Chemistry 278 (25): 22998-23007. 1 January 2003

2002

Alveolar rhabdomyosarcoma with bone marrow infiltration mimicking haematological neoplasia.
Maywald, O., Metzgeroth, G., Schoch, C., Ludwig, W.D., Neff, W., Hehlmann, R. and Hastka, J.
British Journal of Haematology 119 : 583. 1 December 2002

Analysis of T-cell receptor V-beta 2 in peripheral blood lymphocytes as a diagnostic marker for Kawasaki disease.
Reichardt, P., Lehmann, I., Sierig, G. and Borte, M.
Infection 30 : 360-364. 1 December 2002

Die Rolle der Polychemotherapie im multimodalen Behandlungskonzept der malignen Knochentumoren [The role of polychemotherapy in the management of malignant bone tumors].
Reichardt, P. and Doerken, B.
Chirurg 73 (12): 1170-1173. 1 December 2002

Oral trofosfamide: an active and well-tolerated maintenance therapy for adult patients with advanced bone and soft tissue sarcomas. Results of a retrospective analysis.
Reichardt, P., Pink, D., Tilgner, J., Kretzschmar, A., Thuss-Patience, P.C. and Doerken, B.
Onkologie 25 (6): 541-546. 1 December 2002

In the presence of bone marrow stromal cells human multiple myeloma cells become independent of the IL-6/gp 130/STAT3 pathway.
Chatterjee, M., Hoenemann, D., Lentzsch, S., Bommert, K., Sers, C., Herrmann, P., Mathas, S., Doerken, B. and Bargou, R.C.
Blood 100 (9): 3311-3318. 1 November 2002

Adenoviral transduction of tumor cells induces apoptosis in co-cultured T lymphocytes.
Scholz, C., Staerck, L., Willimsky, G., Blankenstein, T., Doerken, B. and Daniel, P.T.
Gene Therapy 9 (21): 1438-1446. November 2002

Akute lymphatische Leukaemie des Erwachsenen. Diagnostik, Risikogruppen und Therapie [Acute lymphatic leukemia in the adult. Diagnosis, risk groups and therapy].
Hoelzer, D., Arnold, R., Bartram, C.R., Bohme, A., Freund, M., Ganser, A., Kneba, M., Lipp, T., Ludwig, W.D., Maschmeyer, G., Rieder, H., Thiel, E., Messerer, D., Weiss, A. and Goekbuget, N.
Internist 43 : 1212-22, 1224. 1 October 2002

Flow cytometric immunophenotyping of acute lymphoblastic leukemia: is the time ready for consensus the guidelines?
Basso, G., Lanza, F., Orfao, A., Bene, M., Borowitz, M., Campana, D., Lacombe, F., Ludwig, W.D., Porwitt-MacDonald, A., Rothe, G. and Dworzac, M.
Journalof Biological Regulators and Homeostatic Agents 16 : 257-258. 1 October 2002

Karyotype instability between diagnosis and relapse in 117 patients with acute myeloid leukemia: implications for resistance against therapy.
Kern, W., Haferlach, T., Schnittger, S., Ludwig, W.D., Hiddemann, W. and Schoch, C.
Leukemia 16, 10 : 2084-2091. 1 October 2002

Time-intensified dexamethasone/cisplatin/cytarabine: an effective salvage therapy with low toxicity in patients with relapsed and refractory Hodgkin's disease.
Josting, A., Rudolph, C., Reiser, M., Mapara, M., Sieber, M., Kirchner, H.H., Doerken, B., Hossfeld, D.K., Diehl, V. and Engert, A.
Annals of Oncology 13 (10): 1628-1635. October 2002

Nuclear factor κB-dependent gene expression profiling of Hodgkins disease tumor cells, pathogenetic significance, and link to constitutive signal transducer and activator of transcription 5a activity.
Hinz, M., Lemke, P., Anagnostopoulos, I., Hacker, C., Krappmann, D., Mathas, S., Doerken, B., Zenke, M., Stein, H. and Scheidereit, C.
Journal of Experimental Medicine 196 (5): 605-617. 2 September 2002

Donor lymphocyte infusions mediate superior graft-versus-leukemia effects in mixed compared to fully allogeneic chimeras: a critical role for host antigen-presenting cells.
Mapara, M.Y., Kim, Y.M., Wang, S.P., Bronson, R., Sachs, D.H. and Sykes, M.
Blood 100 : 1903-1909. 1 September 2002

Infant acute lymphoblastic leukemia - combined cytogenetic, immunophenotypical and molecular analysis of 77 cases.
Borkhardt, A., Wuchter, C., Viehmann, S., Pils, S., Teigler-Schlegel, A., Stanulla, M., Zimmermann, M., Ludwig, W.D., Janka-Schaub, G., Schrappe, M. and Harbott, J.
Leukemia 16, 9 : 1685-1690. 1 September 2002

Proteasome inhibitor PS-341 inhibits human myeloma cell growth in vivo and prolongs survival in a murine model.
LeBlanc, R., Catley, L.P., Hideshima, T., Lentzsch, S., Mitsiades, C.S., Mitsiades, N., Neuberg, D., Goloubeva, O., Pien, C.S., Adams, J., Gupta, D., Richardson, P.G., Munshi, N.C. and Anderson, K.C.
Cancer Research 62 (17): 4996-5000. 1 September 2002

The vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584 inhibits growth and migration of multiple myeloma cells in the bone marrow microenvironment.
Lin, B., Podar, K., Gupta, D., Tai, Y.T., Li, S., Weller, E., Hideshima, T., Lentzsch, S., Davies, F., Li, C., Weisberg, E., Schlossman, R.L., Richardson, P.G., Griffin, J.D., Wood, J., Munshi, N.C. and Anderson, K.C.
Cancer Research 62 : 5019-5026. 1 September 2002

Extremely potent, rapid and costimulation-independent cytotoxic T-cell response against lymphoma cells catalyzed by a single-chain bispecific antibody.
Dreier, T., Lorenczewski, G., Brandl, C., Hoffmann, P., Syring, U., Hanakam, F., Kufer, P., Riethmuller, G., Bargou, R. and Baeuerle, P.A.
International Journal of Cancer 100 (6): 690-697. 20 August 2002

Laser-induzierte Thermotherapie (LITT) bei malignen Lebertumoren: Einsatz der Sonographie zur Katheterplatzierung und Prozessbeobachtung [Laser-induced thermotherapy (LITT) for malignant liver tumours: the role of sonography in catheter placement and observation of the therapeutic procedure].
Stroszczynski, C., Gretschel, S., Gaffke, G., Puls, R., Kretzschmar, A., Hosten, N., Schlag, P.M. and Felix, R.
Ultraschall in der Medizin 23 (3): 163-167. 8 August 2002

Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B.
Mathas, S., Hinz, M., Anagnostopoulos, L., Krappmann, D., Lietz, A., Jundt, F., Bommert, K., Mechta-Grigoriou, F., Stein, H., Dörken, B. and Scheidereit, C.
EMBO Journal 21 (15): 4104-4113. 1 August 2002

In vitro drug resistance profile of Philadelphia positive acute lymphoblastic leukemia is heterogeneous and related to age: a report of the Dutch and German Leukemia Study Groups.
Ramakers-van Woerden, N.L., Pieters, R., Hoelzer, D., Slater, R.M., den Boer, M.L., Loonen, A.H., Harbott, J., Janka-Schaub, G.E., Ludwig, W.D., Ossenkoppele, G.J., van Wering, E.R. and Veerman, A.J.
Medical and Pediatric Oncology 38 : 379-386. 1 June 2002

In vitro susceptibility to dexamethasone- and doxorubicin-induced apoptotic cell death in context of maturation stage, responsiveness to interleukin 7, and early cytoreduction in vivo in childhood T-cell acute lymphoblastic leukemia.
Wuchter, C., Ruppert, V., Schrappe, M., Doerken, B., Ludwig, W.D. and Karawajew, L.
Blood 99 (11): 4109-4115. 1 June 2002

Assessment of genomic instability in breast cancer and uveal melanoma by random amplified polymorphic DNA analysis.
Papadopoulos, S., Benter, T., Anastassiou, G., Pape, M., Gerhard, S., Bornfeld, N., Ludwig, W.D. and Doerken, B.
International Journal of Cancer 99 (2): 193-200. 10 May 2002

A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy.
Schmitt, C.A., Fridman, J.S., Yang, M., Lee, S., Baranov, E., Hoffman, R.M. and Lowe, S.W.
Cell 109 (3): 335-346. 3 May 2002

Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma.
Jundt, F., Anagnostopoulos, I., Foerster, R., Mathas, S., Stein, H. and Doerken, B.
Blood 99 (9): 3398-3403. 1 May 2002

Hepatocarcinoma cells constitutively expressing adenoviral E1-genes provide a tumor model for intratumoral replication of E1-deficient adenoviruses.
Cichon, G., Boeckh-Herwig, S., Elezkurtaj, S., Schmidt, H.H., Hofmann, C. and Arnold, W.
Anticancer Research 22 (1A): 197-201. May 2002

Human cytomegalovirus gene products US2 and US11 differ in their ability to attack major histocompatibility class I heavy chains in dendritic cells.
Rehm, A., Engelsberg, A., Tortorella, D., Körner, I.J., Lehmann, I., Ploegh, H.L. and Höpken, U.E.
Journal of Virology 76 (10): 5043-5050. May 2002

Loss of PU.1 expression is associated with defective immunoglobulin transcription in Hodgkin and Reed-Sternberg cells of classical Hodgkin disease.
Jundt, F., Kley, K., Anagnostopoulos, I., Schulze-Proebsting, K., Greiner, A., Mathas, S., Scheidereit, C., Wirth, T., Stein, H. and Doerken, B.
Blood 99 (8): 3060-3062. 15 April 2002

S-3-Amino-phthalimido-glutarimide inhibits angiogenesis and growth of B-cell neoplasias in mice.
Lentzsch, S., Rogers, M.S., LeBlanc, R., Birsner, A.E., Shah, J.H., Treston, A.M., Anderson, K.C. and D'Amato, R.J.
Cancer Research 62 : 2300-2305. 15 April 2002

Dissecting p53 tumor suppressor functions in vivo.
Schmitt, C.A., Fridman, J.S., Yang, M., Baranov, E., Hoffman, R.M. and Lowe, S.W.
Cancer Cell 1 (3): 289-298. 1 April 2002

Morphologic diagnosis of leukaemic B-lymphoproliferative disorders and the role of cyclin D1 expression.
Oertel, J., Kingreen, D., Busemann, C., Stein, H. and Doerken, B.
Journal of Cancer Research and Clinical Oncology 128 (4): 182-188. April 2002

Acute myeloid leukemia: treatment over 60.
Buechner, T., Hiddemann, W., Berdel, W., Woermann, B., Schoch, C., Loffler, H., Haferlach, T., Schumacher, A., Staib, P., Balleisen, L., Gruneisen, A., Rasche, H., Aul, C., Heyll, A., Lengfelder, E., Ludwig, W.D., Maschmeyer, G., Eimermacher, H., Karow, J., Frickhofen, N., Hirschmann, W.D. and Sauerland, M.C.
Reviews in Clinical and Experimental Hematology 6, 1 : 46-59. 1 March 2002

Apoptosis and chemoresistance in transgenic cancer models.
Schmitt, C.A. and Lowe, S.W.
Journal of Molecular Medicine 80 (3): 137-146. March 2002

Infection of cells with replication deficient adenovirus induces cell cycle alterations and leads to downregulation of E2F-1.
Kuhn, H., Liebers, U., Gessner, C., Karawajew, L., Ruppert, V., Schumacher, A., Witt, C. and Wolff, G.
Biochimica et Biophysica Acta 1542 : 106-115. 30 January 2002

Adenovirus-mediated gene transfer of P161NK4/CDKN2 into bax-negative colon cancer cells induces apoptosis and tumor regression in vivo.
Tamm, I., Schumacher, A., Karawajew, L., Ruppert, V., Arnold, W., Nuessler, A.K., Neuhaus, P., Doerken, B. and Wolff, G.
Cancer Gene Therapy 9 : 641-650. 1 January 2002

BALTOMe - ein Langzeitverlauf [BALTOMA - long-term follow-up].
Gaffke, G., Stroszczynski, C., Ludwig, W.D., Puls, R., Schlecht, I., Jost, D., Hosten, N. and Felix, R.
Roentgenpraxis 54 (5): 186-191. 1 January 2002

Diagnostik von Duenndarmtumoren mit Hilfe des CT-Enteroklysma. Die CT--Sellink ausgewertet bei 63 Patienten [Diagnosis of tumors of the small intestine with the aid of CT contrast enema. Sellink CT technique evaluated in 63 patients].
Gaffke, G., Stroszczynski, C., Schlecht, I., Jost, D., Ludwig, W.D., Schlag, P.M. and Felix, R.
Roentgenpraxis 54 (6): 214-219. 1 January 2002

Sp1 as G1 cell cycle phase specific transcription factor in epithelial cells.
Grinstein, E., Jundt, F., Weinert, I., Wernet, P. and Royer, H.D.
Oncogene 21 : 1485-1492. 1 January 2002

Surface expression and endocytosis of the human cytomegalovirus-encoded chemokine receptor US28 is regulated by agonist-independent phosphorylation.
Mokros, T., Rehm, A., Droese, J., Oppermann, M., Lipp, M. and Höpken, U.E.
Journal of Biological Chemistry 277 (47): 45122-45128. 1 January 2002

Y-box factor YB-1 predicts drug resistance and patient outcome in breast cancer independent of clinically relevant tumor biologic factors HER2, uPA and PAI-1.
Janz, M., Harbeck, N., Dettmar, P., Berger, U., Schmidt, A., Juerchott, K., Schmitt, M. and Royer, H.D.
International Journal of Cancer 97 (3): 278-282. 1 January 2002

Therapie eines Zenker'schen Divertikels [Therapy of Zenker's divertikulum].
Benter, T., Kretzschmar, A., Reich, G., Papadopoulos, S., Kluhs, L., Ludwig, W.D. and Doerken, B.
Medizinische Klinik 97 (1): 44-45. January 2002

2001

Adherence of multiple myeloma cells to bone marrow stromal cells upregulates vascular endothelial growth factor secretion: therapeutic applications.
Gupta, D., Treon, S.P., Shima, Y., Hideshima, T., Podar, K., Tai, Y.T., Lin, B., Lentzsch, S., Davies, F.E., Chauhan, D., Schlossman, R.L., Richardson, P., Ralph, P., Wu, L., Payvandi, F., Muller, G., Stirling, D.I. and Anderson, K.C.
Leukemia 15 : 1950-1961. 1 December 2001

Cytogenetic and molecular characterization of a patient with simultaneous B-cell chronic lymphocytic leukemia and peripheral T-cell lymphoma.
Martin-Subero, J.I., Siebert, R., Harder, L., Gesk, S., Schwindt, P., Braeuninger, A., Willenbrock, K., Steinemann, D., Tiemann, M., Calasanz, M.J., Grote, W., Ludwig, W.D., Hansmann, M.L. and Schlegelberger, B.
American Journal of Hematology 68 : 276-279. 1 December 2001

Mechanism of action of thalidomide and 3-aminothalidomide in multiple myeloma.
D'Amato, R.J., Lentzsch, S., Anderson, K.C. and Rogers, M.S.
Seminars in Oncology 28, 6 : 597-601. 1 December 2001

Piceatannol, a hydroxylated analog of the chemopreventive agent resveratrol, is a potent inducer of apoptosis in the lymphoma cell line BJAB and in primary, leukemic lymphoblasts.
Wieder, T., Prokop, A., Bagci, B., Essmann, F., Bernicke, D., Schulze-Osthoff, K., Doerken, B., Schmalz, H.G., Daniel, P.T. and Henze, G.
Leukemia 15 (11): 1735-1742. 1 November 2001

Polypoide Magenbeteiligung beim Plasmozytom [Polypoid gastric involvement in plasmacytoma].
Benter, T., Kluehs, L., Gabor, C., Spahn, G. and Doerken, B.
Medizinische Klinik 96 (8): 489-490. 15 August 2001

Antisense therapy in oncology: new hope for an old idea?
Tamm, I., Doerken, B. and Hartmann, G.
Lancet 358 (9280): 489-497. 11 August 2001

Remission induction therapy: the more intensive the better?
Buechner, T., Hiddemann, W., Berdel, W., Woermann, B., Loeffler, H., Schoch, C., Haferlach, T., Ludwig, W.D., Maschmeyer, G., Staib, P., Andreesen, R., Balleisen, L., Haase, D., Eimermacher, H., Aul, C., Rasche, H., Uhlig, J., Grueneisen, A., Reis, H.E., Hartlapp, J., Hirschmann, W.D., Weh, H.J., Pielken, H.J., Gassmann, W., Sauerland, M.C. and Heinecke, A.
Cancer Chemotherapy and Pharmacology 48 Suppl 1 : S41-S44. 1 August 2001

The Bax/Bcl-2 ratio determines the susceptibility of human melanoma cells to CD95/Fas-mediated apoptosis.
Raisova, M., Hossini, A.M., Eberle, J., Riebeling, C., Wieder, T., Sturm, I., Daniel, P.T., Orfanos, C.E. and Geilen, C.C.
Journal of Investigative Dermatology 117 (2): 333-340. 1 August 2001

The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia.
Fuchs, U., Rehkamp, G., Haas, O.A., Slany, R., Konig, M., Bojesen, S., Bohle, R.M., Damm-Welk, C., Ludwig, W.D., Harbott, J. and Borkhardt, A.
Proceedings of the National Academy of Sciences of the United States of America 98 (15): 8756-8761. 17 July 2001

Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration.
Podar, K., Tai, Y.T., Davies, F.E., Lentzsch, S., Sattler, M., Hideshima, T., Lin, B.K., Gupta, D., Shima, Y., Chauhan, D., Mitsiades, C., Raje, N., Richardson, P. and Anderson, K.C.
Blood 98 (2): 428-435. 15 July 2001

Oncolytic viruses as therapeutic agents.
Wildner, O.
Annals of Medicine 33 : 291-304. 1 July 2001

Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma.
Davies, F.E., Raje, N., Hideshima, T., Lentzsch, S., Young, G., Tai, Y.T., Lin, B., Podar, K., Gupta, D., Chauhan, D., Treon, S.P., Richardson, P.G., Schlossman, R.L., Morgan, G.J., Muller, G.W., Stirling, D.I. and Anderson, K.C.
Blood 98 (1): 210-216. 1 July 2001

The kiss of death: promises and failures of death receptors and ligands in cancer therapy.
Daniel, P.T., Wieder, T., Sturm, I. and Schulze-Osthoff, K.
Leukemia 15 (7): 1022-1032. 1 July 2001

Verfahren zur Verbesserung des Gentransfers von genetischem Material in Saeugerzellen durch die Verwendung von P21 (WAF-1) [Method for improving the gene transfer of genetic material in mammalian cells through the use of P21 (WAF-1)].
Doerken, B., Wolff, G. and Schumacher, A.
EP1097234. 13 June 2001

Overexpression of caspase-3 restores sensitivity for drug-induced apoptosis in breast cancer cell lines with acquired drug resistance.
Friedrich, K., Wieder, T., von Haefen, C., Radetzki, S., Jaenicke, R., Schulze-Osthoff, K., Doerken, B. and Daniel, P.T.
Oncogene 20 (22): 2749-2760. 17 May 2001

Spectral karyotyping and fluorescence in situ hybridization detect novel chromosomal aberrations, a recurring involvement of chromosome 21 and amplification of the MYC oncogene in acute myeloid leukaemia M2.
Hilgenfeld, E., Padilla-Nash, H., McNeil, N., Knutsen, T., Montagna, C., Tchinda, J., Horst, J., Ludwig, W.D., Serve, H., Buechner, T., Berdel, W.E., Schroeck, E. and Ried, T.
British Journal of Haematology 113 : 305-317. 1 May 2001

Signal peptide cleavage of a type I membrane protein, HCMV US11, is dependent on its membrane anchor.
Rehm, A., Stern, P., Ploegh, H.L. and Tortorella, D.
EMBO Journal 20 (7): 1573-1582. 2 April 2001

Apoptosis is critical for drug response in vivo.
Schmitt, C.A. and Lowe, S.W.
Drug Resistance Updates 4 (2): 132-134. April 2001

Activation of caspase-8 in drug-induced apoptosis of B-lymphoid cells is independent of CD95/Fas receptor-ligand interaction and occurs downstream of caspase-3.
Wieder, T., Essmann, F., Prokop, A., Schmelz, K., Schulze-Osthoff, K., Beyaert, R., Doerken, B. and Daniel, P.T.
Blood 97 (5): 1378-1387. 1 March 2001

Infectious complications after high-dose chemotherapy and autologous stem cell transplantation: comparison between patients with lymphoma or multiple myeloma and patients with solid tumors.
Reich, G., Mapara, M.Y., Reichardt, P., Doerken, B. and Maschmeyer, G.
Bone Marrow Transplantation 27 : 525-529. 1 March 2001

Gene transfer of heat-shock protein 70 reduces infarct size in vivo after ischemia/reperfusion in the rabbit heart.
Okubo, S., Wildner, O., Shah, M.R., Chelliah, J.C., Hess, M.L. and Kukreja, R.C.
Circulation 103 (6): 877-881. 13 February 2001

Four patients with AL amyloidosis treated with high-dose chemotherapy and autologous stem cell transplantation.
Reich, G., Held, T., Siegert, W., Kampf, D., Doerken, B. and Maschmeyer, G.
Bone Marrow Transplantation 27 : 341-343. 1 February 2001

Anatomical variations in the internal jugular veins of cancer patients affecting central venous access. Anatomical variation of the internal jugular vein.
Benter, T., Teichgraeber, U.K., Kluehs, L., Papadopoulos, S., Koehne, C.H., Felix, R. and Doerken, B.
Ultraschall in der Medizin 22 (1): 23-26. February 2001

Acute myeloid leukaemia MO: haematological, immunophenotypic and cytogenetic characteristics and their prognostic significance: an analysis in 241 patients.
Bene, M.C., Bernier, M., Casasnovas, R.O., Castoldi, G., Doekharan, D., van der Holt, B., Knapp, W., Lemez, P., Ludwig, W.D., Matutes, E., Orfao, A., Schoch, C., Sperling, C. and van't Veer, M.B.
British Journal of Haematology 113 : 737-745. 1 January 2001

Analysis of p53/BAX/p16(ink4a/CDKN2) in esophageal squamous cell carcinoma: High BAX and p16(nk4a/CDKN2) identifies patients with good prognosis.
Sturm, I., Petrowsky, H., Volz, R., Lorenz, M., Radetzki, S., Hillebrand, T., Wolff, G., Hauptmann, S., Doerken, B. and Daniel, P.T.
Journal of Clinical Oncology 19 : 2272-2281. 1 January 2001

Apoptotic response to homoharringtonine in human wt p53 leukemic cells is independent of reactive oxygen species generation and implicates Bax translocation, mitochondrial cytochrome c release and caspase activation.
Cai, Z., Lin, M., Wuchter, C., Ruppert, V., Doerken, B., Ludwig, W.D. and Karawajew, L.
Leukemia 15 : 567-574. 1 January 2001

Bax expression in benign and malignant thyroid tumours: dysregulation of wild-type p53 is associated with a high bax and p21 expression in thyroid carcinoma.
Hermann, S., Sturm, I., Mrozek, A., Klosterhalfen, B., Hauptmann, S., Doerken, B. and Daniel, P.T.
International Journal of Cancer 92 (6): 805-811. 1 January 2001

Cleavage and shedding of E-cadherin after induction of apoptosis.
Steinhusen, U., Weiske, J., Badock, V., Tauber, R., Bommert, K. and Huber, O.
Journal of Biological Chemistry 276 (7): 4972-4980. 1 January 2001

Constitutive NF-kappaB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells.
Hinz, M., Loeser, P., Mathas, S., Krappmann, D., Dörken, B. and Scheidereit, C.
Blood 97 (9): 2798-2807. 1 January 2001

Decreased generation of anti-tumor immunity after intrasplenic immunization.
Cayeux, S., Qin, Z.H., Doerken, B. and Blankenstein, T.
European Journal of Immunology 31 (5): 1392-1399. 1 January 2001

Expansion of hepatic and hematopoietic stem cells utilizing mouse embryonic liver explants.
Monga, S.P., Tang, Y., Candotti, F., Rashid, A., Wildner, O., Mishra, B., Iqbal, S. and Mishra, L.
Cell Transplantation 10 : 81-89. 1 January 2001

Favorable outcome for children and adolescents with T-cell lymphoblastic lymphoma with an intensive ALL-type therapy without local radiotherapy.
Grenzebach, J., Schrappe, M., Ludwig, W.D., Parwaresch, R., Zimmermann, M., Gadner, H., Riehm, H. and Reiter, A.
Annals of Hematology 80 Suppl 3 : B73-B76. 1 January 2001

Impact of CD133 (AC133) and CD90 expression analysis for acute leukemia immunophenotyping.
Wuchter, C., Ratei, R., Spahn, G., Schoch, C., Harbott, J., Schnittger, S., Haferlach, T., Creutzig, U., Sperling, C., Karawajew, L. and Ludwig, W.D.
Haematologica 86 : 154-161. 1 January 2001

Induction of stable long-term mixed hematopoietic chimerism following nonmyeloablative conditioning with T cell-depleting antibodies, cyclophosphamide, and thymic irradiation leads to donor-specific in vitro and in vivo tolerance.
Mapara, M.Y., Pelot, M., Zhao, G., Swenson, K., Pearson, D. and Sykes, M.
Biology of Blood and Marrow Transplantation 7 : 646-655. 1 January 2001

Involvement of BCL-2 and Bax in the IL-3-induced inhibition of spontaneous apoptosis in childhood T-ALL.
Ruppert, V., Wuchter, C., Doerken, B., Ludwig, W.D. and Karawajew, L.
In: Acute Leukemias VIII: Prognostic Factors and Treatment Strategies. Haematologie und Bluttransfusion ; 40 . Springer, Berlin, 128-135. ISBN 3-540-41123-2 1 January 2001

Prefractionation of protein samples for proteome analysis using reversed-phase high-performance liquid chromatography.
Badock, V., Steinhusen, U., Bommert, K. and Otto, A.
Electrophoresis 22 (14): 2856-2864. 1 January 2001

Relevance of Ki-67 antigen expression and K-ras mutation in colorectal liver metastases.
Petrowsky, H., Sturm, I., Graubitz, O., Kooby, D.A., Staib-Sebler, E., Gog, C., Koehne, C.H., Hillebrand, T., Daniel, P.T., Fong, Y. and Lorenz, M.
European Journal of Surgical Oncology 27 (1): 80-87. 1 January 2001

The IL-6 receptor antagonist SANT-7 overcomes bone marrow stromal cell-mediated drug resistance of multiple myeloma cells.
Hoenemann, D., Chatterjee, M., Savino, R., Bommert, K., Burger, R., Gramatzki, M., Doerken, B. and Bargou, R.C.
International Journal of Cancer 93 (5): 674-680. 1 January 2001

Bcl-2 mediates chemoresistance in matched pairs of primary Emu-myc lymphomas in vivo.
Schmitt, C.A. and Lowe, S.W.
Blood Cells Molecules and Diseases 27 (1): 206-216. January 2001

2000

Long-term results of four consecutive trials in childhood ALL performed by the ALL-BFM study group from 1981 to 1995. Berlin-Frankfurt-Munster.
Schrappe, M., Reiter, A., Zimmermann, M., Harbott, J., Ludwig, W.D., Henze, G., Gadner, H., Odenwald, E. and Riehm, H.
Leukemia 14 (12): 2205-2222. 1 December 2000

Treatment of Adult ALL according to protocols of the German Multicenter Study Group for Adult ALL (GMALL).
Goekbuget, N., Hoelzer, D., Arnold, R., Boehme, A., Bartram, C.R., Freund, M., Ganser, A., Kneba, M., Langer, W., Lipp, T., Ludwig, W.D., Maschmeyer, G., Rieder, H., Thiel, E., Weiss, A. and Messerer, D.
Hematology/Oncology Clinics of North America 14 : 1307-1325. 1 December 2000

Salvage therapy for relapsed mediastinal B-cell lymphoma with allogeneic HLA-identical related donor bone marrow transplantation, donor lymphocyte infusion and IDEC-C2B8.
Ratei, R., Matylis, A., Krahl, D., Arnold, R., Stein, H., Doerken, B. and Ludwig, W.D.
Leukemia & Lymphoma 40 (1-2): 133-140. December 2000

Acute myeloid leukemia in adults: is postconsolidation maintenance therapy necessary?
Buechner, T., Hiddemann, W., Woermann, B., Loeffler, H., Ludwig, W.D., Schoch, C., Haferlach, T., Maschmeyer, G., Staib, P., Aul, C., Heyll, G.A., Gruneisen, A., Rasche, H., Eimermacher, J.H., Balleisen, L., Pielken, H.J., Reis, H.E., Griesinger, F., Reichle, A., Sauerland, M.C. and Heinecke, A.
International Journal of Hematology 72 : 285-289. 1 October 2000

Genetic analysis of chemoresistance in primary murine lymphomas.
Schmitt, C.A., Rosenthal, C.T. and Lowe, S.W.
Nature Medicine 6 : 1029-1035. 1 September 2000

Relapse in childhood acute lymphoblastic leukemia is associated with a decrease of the Bax/Bcl-2 ratio and loss of spontaneous caspase-3 processing in vivo.
Prokop, A., Wieder, T., Sturm, I., Essmann, F., Seeger, K., Wuchter, C., Ludwig, W.D., Henze, G., Doerken, B. and Daniel, P.T.
Leukemia 14 : 1606-1613. 1 September 2000

Therapy of peritoneal carcinomatosis from colon cancer with oncolytic adenoviruses.
Wildner, O. and Morris, J.C.
Journal of Gene Medicine 2 (5): 353-360. 1 September 2000

Impaired bax protein expression in breast cancer: mutational analysis of the bax and the p53 gene.
Sturm, I., Papadopoulos, S., Hillebrand, T., Benter, T., Luck, H.J., Wolff, G., Doerken, B. and Daniel, P.T.
International Journal of Cancer 87 : 517-521. 15 August 2000

Double induction strategy including high dose cytarabine in combination with all-trans retinoic acid: effects in patients with newly diagnosed acute promyelocytic leukemia. German AML Cooperative Group.
Lengfelder, E., Reichert, A., Schoch, C., Haase, D., Haferlach, T., Loeffler, H., Staib, P., Heyll, A., Seifarth, W., Saussele, S., Fonatsch, C., Gassmann, W., Ludwig, W.D., Hochhaus, A., Beelen, D., Aul, C., Sauerland, M.C., Heinecke, A., Hehlmann, R., Woermann, B., Hiddemann, W. and Buechner, T.
Leukemia 14 : 1362-1370. 1 August 2000

Oral trofosfamide in elderly and/or heavily pretreated patients with metastatic lung cancer.
Horvath, V., Hartlapp, J.H., Hegewisch-Becker, S., Feyerabend, T., von Weikersthal, L.F., Illiger, H.J., Jaeger, E., Peters, S.O., Reichardt, P., Uthgenannt, D., Weber, K., Wagner, T., Wiedemann, G.J. and Zschaber, R.
Onkologie 23 : 341-344. 1 August 2000

The role of the E1B 55 kDa gene product in oncolytic adenoviral vectors expressing herpes simplex virus-tk: Assessment of antitumor efficacy and toxicity.
Wildner, O. and Morris, J.C.
Cancer Research 60 (15): 4167-4174. 1 August 2000

Clinical significance of P-glycoprotein expression and function for response to induction chemotherapy, relapse rate and overall survival in acute leukemia.
Wuchter, C., Karawajew, L., Ruppert, V., Schrappe, M., Buechner, T., Schoch, C., Haferlach, T., Harbott, J.N., Ratei, R., Doerken, B. and Ludwig, W.D.
Haematologica 85 : 711-721. 1 July 2000

Constitutive expression levels of CD95 and Bcl-2 as well as CD95 function and spontaneous apoptosis in vitro do not predict the response to induction chemotherapy and relapse rate in childhood acute lymphoblastic leukaemia.
Wuchter, C., Karawajew, L., Ruppert, V., Schrappe, M., Harbott, J., Ratei, R., Doerken, B. and Ludwig, W.D.
British Journal of Haematology 110 : 154-160. 1 July 2000

Detection of acute leukemia cells with mixed lineage leukemia (MLL) gene rearrangements by flow cytometry using monoclonal antibody 7.1.
Wuchter, C., Harbott, J., Schoch, C., Schnittger, S., Borkhardt, A., Karawajew, L., Ratei, R., Ruppert, V., Haferlach, T., Creutzig, U., Doerken, B. and Ludwig, W.D.
Leukemia 14 : 1232-1238. 1 July 2000

Inhibition of in vitro spontaneous apoptosis by IL-7 correlates with Bcl-2 up-regulation, cortical/mature immunophenotype, and better early cytoreduction of childhood T-cell acute lymphoblastic leukemia.
Karawajew, L., Ruppert, V., Wuchter, C., Koesser, A., Schrappe, M., Doerken, B. and Ludwig, W.D.
Blood 96 : 297-306. 1 July 2000

Precursor B-cell lymphoblastic lymphoma in childhood and adolescence: Clinical features, treatment, and results in trials NHL-BFM 86 and 90.
Neth, O., Seidemann, K., Jansen, P., Mann, G., Tiemann, M., Ludwig, W.D., Riehm, H. and Reiter, A.
Medical and Pediatric Oncology 35 : 20-27. 1 July 2000

Improved outcome in childhood acute lymphoblastic leukemia despite reduced use of anthracyclines and cranial radiotherapy: results of trial ALL-BFM 90. German-Austrian-Swiss ALL-BFM Study Group.
Schrappe, M., Reiter, A., Ludwig, W.D., Harbott, J., Zimmermann, M., Hiddemann, W., Niemeyer, C., Henze, G., Feldges, A., Zintl, F., Kornhuber, B., Ritter, J., Welte, K., Gadner, H. and Riehm, H.
Blood 95 (11): 3310-3322. 1 June 2000

Ultraschallgesteuerte Punktionstechnik von zentral-venoesen Gefaessen in Ein-Personen-Technik [Ultrasonographically guided puncture technique for central venous vessels as a one-person technique].
Teichgraeber, U.K., Benter, T., Schultz, H.J., Kluehs, L., Gutberlet, M. and Felix, R.
Ultraschall in der Medizin 21 : 132-136. 1 June 2000

Weekly 24-Hour infusion of high-dose 5-fluorouracil plus folinic acid in combination with mitomycin C for the treatment of advanced gastric cancer.
Kretzschmar, A., Reichardt, P., Thuss-Patience, P.C., Hohenberger, P., Benter, T., Doerken, B. and Koehne, C.H.
Oncology 59 (1): 14-17. June 2000

Resistance to CD95/Fas-induced and ceramide-mediated apoptosis of human melanoma cells is caused by a defective mitochondrial cytochrome c release.
Raisova, M., Bektas, M., Wieder, T., Daniel, P., Eberle, J., Orfanos, C.E. and Geilen, C.C.
FEBS Letters 473 : 27-32. 4 May 2000

Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias.
Tamm, I., Kornblau, S.M., Segall, H., Krajewski, S., Welsh, K., Kitada, S., Scudiero, D.A., Tudor, G., Qui, Y.H., Monks, A., Andreeff, M. and Reed, J.C.
Clinical Cancer Research 6 (5): 1796-1803. 1 May 2000

Structurally diverse forms of HLA-B27 molecules are displayed in vivo in a cell type-dependent manner.
Rehm, A., Rohr, A., Seitz, C., Wonigeit, K., Ziegler, A. and Uchanska-Ziegler, B.
Human Immunology 61 : 408-418. 1 April 2000

Internal gallbladder drainage in a patient with malignant cystic duct stenosis due to sarcoma.
Benter, T., Kluehs, L., Teichgraeber, U.K., Papadopoulos, S., Meissner, E. and Doerken, B.
Endoscopy 32 (4): S18-S19. April 2000

Verfahren zur Optimierung der Produktion von Adenovirus-Vektoren.
Wolff, G., Schumacher, A. and Doerken, B.
DE19830907A1 ; EP1097235. 16 March 2000

GDP dissociation inhibitor D4-GDI (Rho-GDI 2), but not the homologous Rho-GDI 1, is cleaved by caspase-3 during drug-induced apoptosis.
Essmann, F., Wieder, T., Otto, A., Mueller, E.C., Doerken, B. and Daniel, P.T.
Biochemical Journal 346 (3): 777-783. 15 March 2000

A phase I study of intralesional administration of an adenovirus vector expressing the HSV-1 thymidine kinase gene (AdV.RSV-TK) in combination with escalating doses of ganciclovir in patients with cutaneous metastatic malignant melanoma.
Morris, J.C., Ramsey, W.J., Wildner, O., Muslow, H.A., Aguilar-Cordova, E. and Blaese, R.M.
Human Gene Therapy 11 : 487-503. 10 February 2000

Granulocyte colony-stimulating factor receptor expression and 11q23/MLL genotype in childhood acute lymphoblastic leukemia developing during the first 18 months of life.
Stanulla, M., Kasper, B., Schrappe, M., Viehmann, S., Harbott, J., Ludwig, W.D. and Welte, K.
Leukemia 14 : 337-338. 1 February 2000

Structure-dependent effects of glucose-containing analogs of platelet activating factor (PAF) on membrane integrity.
Wiese, A., Wieder, T., Mickeleit, M., Reinoehl, S., Geilen, C.C., Seydel, U. and Reutter, W.
Biological Chemistry 381 : 135-144. 1 February 2000

Intensive ALL-type therapy without local radiotherapy provides a 90% event-free survival for children with T-cell lymphoblastic lymphoma: a BFM group report.
Reiter, A., Schrappe, M., Ludwig, W.D., Tiemann, M., Parwaresch, R., Zimmermann, M., Schirg, E., Henze, G., Schellong, G., Gadner, H. and Riehm, H.
Blood 95 : 416-421. 15 January 2000

Verfahren zur Stabilisierung und Verbesserung des Gentransfers von genetischem Material in Saeugerzellen.
Wolff, G., Schumacher, A. and Doerken, B.
DE19830874A1. 13 January 2000

A recombinant bispecific single-chain antibody, CD19 X CD3, induces rapid and high lymphoma-directed cytotoxicity by unstimulated T lymphocytes.
Loeffler, A., Kufer, P., Lutterbuese, R., Zettl, F., Daniel, P.T., Schwenkenbecher, J.M., Riethmueller, G., Doerken, B. and Bargou, R.C.
Blood 95 : 2098-2103. 1 January 2000

Anti-CD20-and B-cell receptor-mediated apoptosis: Evidence for shared intracellular signaling pathways.
Mathas, S., Rickers, A., Bommert, K., Doerken, B. and Mapara, M.Y.
Cancer Research 60 (24): 7170-7176. 1 January 2000

Apoptosis-induced cleavage of beta-catenin by caspase-3 results in proteolytic fragments with reduced transactivation potential.
Steinhusen, U., Badock, V., Bauer, A., Behrens, J., Wittmann-Liebold, B., Doerken, B. and Bommert, K.
Journal of Biological Chemistry 275 (21): 16345-16353. 1 January 2000

DNA damage responses and chemosensitivity in the E mu-myc mouse lymphoma model.
Schmitt, C.A., Wallace-Brodeur, R.R., Rosenthal, C.T., McCurrach, M.E. and Lowe, S.W.
Cold Spring Harbor Symposia on Quantitative Biology 65 : 499-510. 1 January 2000

Molecular analysis of the CALM/AF10 fusion: identical rearrangements in acute myeloid leukemia, acute lymphoblastic leukemia and malignant lymphoma patients.
Bohlander, S.K., Muschinsky, V., Schrader, K., Siebert, R., Schlegelberger, B., Harder, L., Schemmel, V., Fonatsch, C., Ludwig, W.D., Hiddemann, W. and Dreyling, M.H.
Leukemia 14 : 93-99. 1 January 2000

Role of crown-like side chains in the biological activity of substituted-phenoxazone drugs.
Karawajew, L., Glibin, E.N., Maleev, V.Y., Czerwony, G., Doerken, B., Davies, D.B. and Veselkov, A.N.
Anti-Cancer Drug Design 15 : 331-338. 1 January 2000

Therapy of head and neck squamous cell carcinoma with an oncolytic adenovirus expressing HSV-tk.
Morris, J.C. and Wildner, O.
Molecular Therapy 1 : 56-62. 1 January 2000

1999

Clinical significance of CD95, Bcl-2 and Bax expression and CD95 function in adult de novo acute myeloid leukemia in context of P-glycoprotein function, maturation stage, and cytogenetics.
Wuchter, C., Karawajew, L., Ruppert, V., Buechner, T., Schoch, C., Hafelach, T., Ratei, R., Doerken, B. and Ludwig, W.D.
Leukemia 13 : 1943-1953. 1 December 1999

Netzplantechnik zur Zeitplanung bei abdominellen Ultraschalluntersuchungen [Project graph technique for time management in abdominal ultrasound evaluations].
Teichgraeber, U.K.M., Benter, T., Kluehs, L., Schroeder, R.J., Hidajat, N., Doerken, B. and Felix, R.
Ultraschall in der Medizin 20 : 236-241. 1 December 1999

Improved treatment results in childhood B-cell neoplasms with tailored intensification of therapy: a report of the Berlin-Frankfurt-Muenster group trial NHL-BFM 90.
Reiter, A., Schrappe, M., Tiemann, M., Ludwig, W.D., Yakisan, E., Zimmermann, M., Mann, G., Chott, A., Ebell, W., Klingebiel, T., Graf, N., Kremens, B., Mueller-Weihrich, S., Pluess, H.J., Zintl, F., Henze, G. and Riehm, H.
Blood 94 : 3294-3306. 15 November 1999

Cytokine response gene 6 induces p21 and regulates both cell growth and arrest.
Fan, W., Richter, G., Cereseto, A., Beadling, C. and Smith, K.A.
Oncogene 18 : 6573-6582. 11 November 1999

Impact of immunophenotyping on management of acute leukemias.
Bene, M.C., Bernier, M., Castoldi, G., Faure, G.C., Knapp, W., Ludwig, W.D., Matutes, E., Orfao, A. and van't Veer, M.
Haematologica 84 : 1024-1034. 1 November 1999

Overexpression of IkappaBalpha without inhibition of NF-kappaB activity and mutations in the IkappaBalpha gene in Reed-Sternberg cells.
Emmerich, F., Meiser, M., Hummel, M., Demel, G., Foss, H.D., Jundt, F., Mathas, S., Krappmann, D., Scheidereit, C., Stein, H. and Dörken, B.
Blood 94 : 3129-3134. 1 November 1999

INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53.
Schmitt, C.A., McCurrach, M.E., de Stanchina, E., Wallace-Brodeur, R.R. and Lowe, S.W.
Genes & Development 13 (20): 2670-2677. 15 October 1999

Intracellular expression of CD61 precedes surface expression.
Kaefer, G., Willer, A., Ludwig, W.D., Kraemer, A., Hehlmann, R. and Hastka, J.
Annals of Hematology 78 : 472-474. 1 October 1999

Percutaneous central venous catheterization with a lethal complication.
Benter, T., Teichgraeber, U.K.M., Kluehs, L. and Doerken, B.
Intensive Care Medicine 25 : 1180-1182. 1 October 1999

A role for beta2 integrins (CD11/CD18) in the regulation of cytokine gene expression of polymorphonuclear neutrophils during the inflammatory response.
Walzog, B., Weinmann, P., Jeblonski, F., Scharffetter-Kochanek, K., Bommert, K. and Gaehtgens, P.
FASEB Journal 13 (13): 1855-1865. October 1999

Hodgkin/Reed-Sternberg cells induce fibroblasts to secrete eotaxin, a potent chemoattractant for T cells and eosinophils.
Jundt, F., Anagnostopoulos, I., Bommert, K., Emmerich, F., Mueller, G., Foss, H.D., Royer, H.D., Stein, H. and Doerken, B.
Blood 94 : 2065-2071. 15 September 1999

CD95/Fas-triggered apoptosis of activated T lymphocytes is prevented by dendritic cells through a CD58-dependent mechanism.
Daniel, P.T., Scholz, C., Essmann, F., Westermann, J., Pezzutto, A. and Doerken, B.
Experimental Hematology 27 : 1402-1408. 1 September 1999

Prednisone response is the strongest predictor of treatment outcome in infant acute lymphoblastic leukemia.
Doerdelmann, M., Reiter, A., Borkhardt, A., Ludwig, W.D., Goetz, N., Viehmann, S., Gadner, H., Riehm, H. and Schrappe, M.
Blood 94 (4): 1209-1217. 15 August 1999

Expression of the death gene Bik/Nbk promotes sensitivity to drug-induced apoptosis in corticosteroid-resistant T-cell lymphoma and prevents tumor growth in severe combined immunodeficient mice.
Daniel, P.T., Pun, K.T., Ritschel, S., Sturm, I., Holler, J., Doerken, B. and Brown, R.
Blood 94 : 1100-1107. 1 August 1999

Interventional antimicrobial therapy in febrile neutropenic patients.
Maschmeyer, G.
Diagnostic Microbiology and Infectous Disease 34 : 205-212. 1 July 1999

Double induction strategy for acute myeloid leukemia: the effect of high-dose cytarabine with mitoxantrone instead of standard-dose cytarabine with daunorubicin and 6-thioguanine: a randomized trial by the german AML cooperative group.
Buechner, T., Hiddemann, W., Woermann, B., Loeffler, H., Gassmann, W., Haferlach, T., Fonatsch, C., Haase, D., Schoch, C., Hossfeld, D., Lengfelder, E., Aul, C., Heyll, A., Maschmeyer, G., Ludwig, W.D., Sauerland, M.C. and Heinecke, A.
Blood 93 : 4116-4124. 15 June 1999

Aerosolized amphotericin B inhalations as prophylaxis of invasive aspergillus infections during prolonged neutropenia: results of a prospective randomized multicenter trial.
Schwartz, S., Behre, G., Heinemann, V., Wandt, H., Schilling, E., Arning, M., Trittin, A., Kern, W.V., Boenisch, O., Bosse, D., Lenz, K., Ludwig, W.D., Hiddemann, W., Siegert, W. and Beyer, J.
Blood 93 (11): 3654-3661. 1 June 1999

Expression of the C-kit receptor (CD117) is a feature of almost all subtypes of de novo acute myeloblastic leukemia (AML), including cytogenetically good-risk AML, and lacks prognostic significance.
Schwartz, S., Heinecke, A., Zimmermann, M., Creutzig, U., Schoch, C., Harbott, J., Fonatsch, C., Loeffler, H., Buechner, T., Ludwig, W.D. and Thiel, E.
Leukemia & Lymphoma 34 (1-2): 85-94. June 1999

Analysis of the p53/BAX pathway in colorectal cancer: low BAX is a negative prognostic factor in patients with resected liver metastases.
Sturm, I., Koehne, C.H., Wolff, G., Petrowsky, H., Hillebrand, T., Hauptmann, S., Lorenz, M., Doerken, B. and Daniel, P.T.
Journal of Clinical Oncology 17 : 1364-1374. 1 May 1999

Combined positive/ negative selection in stem cell transplantation: perspectives in graft engineering.
Mapara, M.Y., Koerner, I.J., Lentzsch, S., Hildebrandt, M. and Doerken, B.
Infusionstherapie und Transfusionsmedizin 26 : 140-145. 1 May 1999

Brain metastases in breast cancer: prognostic factors and management.
Lentzsch, S., Reichardt, P., Weber, F., Budach, V. and Doerken, B.
European Journal of Cancer 35 : 580-585. 1 April 1999

Regulators of G protein signaling exhibit distinct patterns of gene expression and target G protein specificity in human lymphocytes.
Beadling, C., Druey, K.M., Richter, G., Kehrl, J.H. and Smith, K.A.
Journal of Immunology 162 : 2677-2682. 1 March 1999

Staging and monitoring of malignant lymphoma of the bone: comparison of 67Ga scintigraphy and MRI.
Stroszczynski, C., Oellinger, J., Hosten, N., Spahn, G., Amthauer, H., Ricke, J., Hoffmann, K.T., Eichstaedt, H., Ludwig, W.D. and Felix, R.
Journal of Nuclear Medicine 40 : 387-393. 1 March 1999

Identifikation molekularer Regulatoren der anti-IgM induzierten B-Zell Apoptose.
Rickers, A.
UNSPECIFIED thesis, UNSPECIFIED. 16 February 1999

European surveillance of infections and risk factors in cancer patients.
Buchheidt, D., Hiddemann, W., Schiel, X., Kremery, V., Karthaus, M., Donnelly, J.P., Wilhelm, M., Maschmeyer, G., Link, H., Adam, D. and Helmerking, M.
European journal of clinical microbiology & infectious diseases 18 : 161-163. 1 February 1999

Immunophenotypic and immunogenotypic characteristics of TCR gammadelta+ T cell acute lymphoblastic leukemia.
Langerak, A.W., Wolvers-Tettero, I.L., van den Beemd, M.W.M., van Wering, E.R., Ludwig, W.D., Haehlen, K., Necker, A. and van Dongen, J.J.M.
Leukemia 13 : 206-214. 1 February 1999

Study of Burkitt lymphoma cell line proteins by high resolution two-dimensional gel electrophoresis and nanoelectrospray mass spectrometry.
Mueller, E.C., Schuemann, M., Rickers, A., Bommert, K., Wittmann-Liebold, B. and Otto, A.
Electrophoresis 20 : 320-330. 1 February 1999

Preparative high-resolution two-dimensional electrophoresis enables the identification of RNA polymerase B transcription factor 3 as an apoptosis-associated protein in the human BL60-2 Burkitt lymphoma cell line.
Brockstedt, E., Otto, A., Rickers, A., Bommert, K. and Wittmann-Liebold, B.
Journal of Protein Chemistry 18 (2): 225-231. February 1999

Molecular mechanisms of constitutive NF-kappaB/Rel activation in Hodgkin/Reed-Sternberg cells.
Krappmann, D., Emmerich, F., Kordes, U., Scharschmidt, E., Doerken, B. and Scheidereit, C.
Oncogene 18 : 943-953. 28 January 1999

Results of surgery and multimodal therapy for patients with soft tissue sarcoma invading to vascular structures.
Hohenberger, P., Allenberg, J.R., Schlag, P.M. and Reichardt, P.
Cancer 85 : 396-408. 15 January 1999

Analysis of the p53/BAX pathway: Low BAX expression is a negative prognostic factor in patients with resected liver metastases of colorectal adenocarcinoma.
Daniel, P.T., Sturm, I., Wolff, G., Petrowsky, H., Koehne, C.H., Hillebrand, T., Doerken, B. and Lorenz, M.
Langenbecks Archiv fuer Chirurgie Suppl. 1 : 163-169. 1 January 1999

Apoptosis and therapy.
Schmitt, C.A. and Lowe, S.W.
Journal of Pathology 187 : 127-137. 1 January 1999

Cleavage of transcription factor SP1 by caspases during anti-IgM-induced B-cell apoptosis.
Rickers, A., Peters, N., Badock, V., Beyaert, R., Vandenabeele, P., Doerken, B. and Bommert, K.
European Journal of Biochemistry 261 : 269-274. 1 January 1999

Combined positive/negative purging and transplantation of peripheral blood progenitor cell autografts in breast cancer patients: a pilot study.
Mapara, M.Y., Koerner, I.J., Lentzsch, S., Krahl, D., Reichardt, P. and Doerken, B.
Experimental Hematology 27 : 169-175. 1 January 1999

Detection of genomic DNA fragmentation during apoptosis (DNA ladder) and the simultaneous isolation of RNA from low cell numbers.
Daniel, P.T., Sturm, I., Ritschel, S., Friedrich, K., Doerken, B., Bendzko, P. and Hillebrand, T.
Analytical Biochemistry 266 : 110-115. 1 January 1999

Direct and indirect T cell priming by dendritic cell vaccines.
Cayeux, S., Richter, G., Becker, C., Pezzutto, A., Doerken, B. and Blankenstein, T.
European Journal of Immunology 29 : 225-234. 1 January 1999

Expression and regulation by interferon-gamma of the membrane-bound complement regulators CD46 (MCP), CD55 (DAF) and CD59 in gastrointestinal tumours.
Schmitt, C.A., Schwaeble, W., Wittig, B.M., Meyer Zum Bueschenfelde, K.H. and Dippold, W.G.
European Journal of Cancer 35 : 117-124. 1 January 1999

Humoral immunotherapy and the use of monoclonal antibodies.
Daniel, P.T., Pezzutto, A. and Doerken, B.
In: Textbook of Malignant Haematology. Martin Dunitz Ltd., London, 425-446. 1 January 1999

Vaccines using gene-modified tumor cells.
Cayeux, S., Qin, Z., Doerken, B. and Blankenstein, T.
In: Gene therapy :Principles and Applications. Birkhaeuser, Basel, 283-298. ISBN 3-7643-5972-2 1 January 1999

1998

Immunotherapy of B-cell lymphoma with CD3x19 bispecific antibodies: costimulation via CD28 prevents "Veto" apoptosis of antibody-targeted cytotoxic T cells.
Daniel, P.T., Kroidl, A., Kopp, J., Sturm, I., Moldenhauer, G., Doerken, B. and Pezzutto, A.
Blood 92 (12): 4750-4757. 15 December 1998

Antibodies TC-12 ("unique") and TH-111 (CD96) characterize T-cell acute lymphoblastic leukemia and a subgroup of acute myeloid leukemia.
Gramatzki, M., Ludwig, W.D., Burger, R., Moos, P., Rohwer, P., Grunert, C., Sendler, A., Kalden, J.R., Andreesen, R., Henschke, F. and Moldenhauer, G.
Experimental Hematology 26 : 1209-1214. 1 December 1998

The effect of hexadecylphosphocholine on the proliferation of human keratinocytes in vitro and in vivo.
Wieder, T., Reutter, W., Orfanos, C.E. and Geilen, C.C.
Drugs of Today 34 Suppl. F : 97-105. 1 December 1998

Prognostic value of minimal residual disease in acute lymphoblastic leukaemia in childhood.
van Dongen, J.J., Seriu, T., Panzer-Gruemayer, E.R., Biondi, A., Pongers-Willemse, M.J., Corral, L., Stolz, F., Schrappe, M., Masera, G., Kamps, W.A., Gadner, H., van Wering, E.R., Ludwig, W.D., Basso, G., de Bruijn, M.A., Cazzaniga, G., Hettinger, K., van der Does-van den Berg, A., Hop, W.C., Riehm, H. and Bartram, C.R.
Lancet 352 (9142): 1731-1738. 28 November 1998

Growth and differentiation of human stem cell factor/erythropoietin-dependent erythroid progenitor cells in vitro.
Panzenboeck, B., Bartunek, P., Mapara, M.Y. and Zenke, M.
Blood 92 (10): 3658-3668. 15 November 1998

Retrovirales Vektorsystem zur Optimierung des Gentransfers und der Genexpression in primaeren humanen T-Lymphozyten.
Schroeder, A., Schwenkenbecher, J.M. and Bargou, R.
DE19720152A1. 5 November 1998

Spiral-CT. Besseres Aufloesungsvermoegen durch groesseren Pitch?
Rockstroh, G.
Aktuelle Radiologie 8 : 250-252. 1 November 1998

Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line - cleavage of heterogeneous nuclear ribonucleoprotein A1 by caspase 3.
Brockstedt, E., Rickers, A., Kostka, S., Laubersheimer, A., Doerken, B., Wittmann-Liebold, B., Bommert, K. and Otto, A.
Journal of Biological Chemistry 273 (43): 28057-28064. 23 October 1998

Detection of tumor cells in peripheral blood samples from patients with germ cell tumors using immunocytochemical and reverse transcriptase-polymerase chain reaction techniques.
Hildebrandt, M., Blaser, F., Beyer, J., Siegert, W., Mapara, M.Y., Huhn, D. and Salama, A.
Bone Marrow Transplantation 22 : 771-775. 1 October 1998

Immunophenotypic and genotypic features, clinical characteristics, and treatment outcome of adult pro-B acute lymphoblastic leukemia: Results of the German multicenter trials GMALL 03/87 and 04/89.
Ludwig, W.D., Rieder, H., Bartram, C.R., Heinze, B., Schwartz, S., Gassmann, W., Loeffler, H., Hossfeld, D., Heil, G., Handt, S., Heyll, A., Diedrich, H., Fischer, K., Weiss, A., Voelkers, B., Aydemir, U., Fonatsch, C., Goekbuget, N., Thiel, E. and Hoelzer, D.
Blood 92 (6): 1898-1909. 15 September 1998

Granulocyte colony-stimulating factor shortens duration of critical neutropenia and prolongs disease-free survival after sequential high-dose cytosine arabinoside and mitoxantrone (S-HAM) salvage therapy for refractory and relapsed acute myeloid leukemia.
Kern, W., Aul, C., Maschmeyer, G., Kuse, R., Kerkhoff, A., Grote-Metke, A., Eimermacher, H., Kubica, U., Woermann, B., Buechner, T. and Hiddemann, W.
Annals of Hematology 77 : 115-122. 1 September 1998

High rate of chromosome abnormalities detected by fluorescence in situ hybridization using BCR and ABL probes in adult acute lymphoblastic leukemia.
Rieder, H., Bonwetsch, C., Janssen, L.A.J., Maurer, J., Janssen, J.W.G., Schwartz, S., Ludwig, W.D., Gassmann, W., Bartram, C.R., Thiel, E., Loeffler, H., Gokbuget, N., Hoelzer, D. and Fonatsch, C.
Leukemia 12 : 1473-1481. 1 September 1998

Immunophenotype and clinical characteristics of CD45-negative and CD45-positive childhood acute lymphoblastic leukemia.
Ratei, R., Sperling, C., Karawajew, L., Schott, G., Schrappe, M., Harbott, J., Riehm, H. and Ludwig, W.D.
Annals of Hematology 77 : 107-114. 1 September 1998

Loss of laminin and of the laminin receptor integrin subunit � in situ correlates with cytokine induced down regulation of alpha 6 on fibroblast-like synoviocytes from rheumatoid arthritis.
Rinaldi, N., Barth, T.F., Weis, D., Schwarz-Eywill, M., Pezzutto, A., Lukoschek, M., Brocai, D. and Brado, B.
Annals of the Rheumatic Diseases 57 : 559-565. 1 September 1998

Sequence analysis of the first HTLV-I infection in Germany without relations to endemic areas-short communication.
Ellerbrok, H., Fleischer, C., Salemi, M., Reinhardt, P., Ludwig, W.D., Vandamme, A.M. and Pauli, G.
AIDS Research and Human Retroviruses 14 : 1199-1203. 1 September 1998

Expression and regulation of c-kit receptor and response to stem cell factor in childhood malignant T-lymphoblastic cells.
Tomeczkowski, J., Frick, D., Schwinzer, B., Wittner, N., Ludwig, W.D., Reiter, A., Welte, K. and Sykora, K.W.
Leukemia 12 : 1221-1229. 1 August 1998

High performance two dimensional gel electrophoresis and nanoelectrospray mass spectrometry as powerful tool to study apoptosis-associated processes in a Burkitt lymphoma cell line.
Otto, A., Mueller, E.C., Brockstedt, E., Schumann, M., Rickers, A., Bommert, K. and Wittmann-Liebold, B.
Journal of Protein Chemistry 17 : 564-565. 1 August 1998

Mutation analysis of CD95 (APO-1/Fas) in childhood B-lineage acute lymphoblastic leukaemia.
Beltinger, C., Boehler, T., Karawajew, L., Ludwig, W.D., Schrappe, M. and Debatin, K.M.
British Journal of Haematology 102 : 722-728. 1 August 1998

The reliability and specificity of c-kit for the diagnosis of acute myeloid leukemias and undifferentiated leukemias.
Bene, M.C., Bernier, M., Casasnovas, R.O., Castoldi, G., Knapp, W., Lanza, F., Ludwig, W.D., Matutes, E., Orfao, A., Sperling, C. and van't Veer, M.B.
Blood 92 (2): 596-599. 15 July 1998

Superiority of high-dose over intermediate-dose cytosine arabinoside in the treatment of patients with high-risk acute myeloid leukemia: results of an age-adjusted prospective randomized comparison.
Kern, W., Aul, C., Maschmeyer, G., Schoenrock-Nabulsi, R., Ludwig, W.D., Bartholomaeus, A., Bettelheim, P., Woermann, B., Buechner, T. and Hiddemann, W.
Leukemia 12 : 1049-1055. 1 July 1998

MLL and CALM are fused to AF10 in morphologically distinct subsets of acute leukemia with translocation t(10;11): both rearrangements are associated with a poor prognosis.
Dreyling, M.H., Schrader, K., Fonatsch, C., Schlegelberger, B., Haase, D., Schoch, C., Ludwig, W.D., Loeffler, H., Buechner, T., Wormann, B., Hiddemann, W. and Bohlander, S.K.
Blood 91 (12): 4662-4667. 15 June 1998

CD95 (APO-1/Fas) mutations in childhood T-lineage acute lymphoblastic leukemia.
Beltinger, C., Kurz, E., Boehler, T., Schrappe, M., Ludwig, W.D. and Debatin, K.M.
Blood 91 (10): 3943-3951. 15 May 1998

Down's syndrome in childhood acute lymphoblastic leukemia: clinical characteristics and treatment outcome in four consecutive BFM trials.
Dordelmann, M., Schrappe, M., Reiter, A., Zimmermann, M., Graf, N., Schott, G., Lampert, F., Harbott, J., Niemeyer, C., Ritter, J., Dorffel, W., Nessler, G., Kuhl, J. and Riehm, H.
Leukemia 12 : 645-651. 1 May 1998

Induction of ceramide-mediated apoptosis by the anticancer pPhospholipid analog, hexadecylphosphocholine.
Wieder, T., Orfanos, C.E. and Geilen, C.C.
Journal of Biological Chemistry 273 (18): 11025-11031. 1 May 1998

Dose-intensive chemotherapy with ifosfamide, epirubicin, and filgrastim for adult patients with metastatic or locally advanced soft tissue sarcoma: A phase II study.
Reichardt, P., Tilgner, J., Hohenberger, P. and Doerken, B.
Journal of Clinical Oncology 16 (4): 1438-1443. April 1998

Expression and regulation of phospholipase D in the human keratinocyte cell line HaCaT.
Mueller-Wieprecht, V., Riebeling, C., Alexander, C., Scholz, F.R., Hoeer, A., Wieder, T., Orfanos, C.E. and Geilen, C.C.
FEBS Letters 425 : 199-203. 27 March 1998

Correlation of cytogenetic, molecular cytogenetic, and clinical findings in 59 patients with ANLL or MDS and abnormalities of the short arm of chromosome 12.
Streubel, B., Sauerland, C., Heil, G., Freund, M., Bartels, H., Lengfelder, E., Wandt, H., Ludwig, W.D., Nowotny, H., Baldus, M., Grothaus-Pinke, B., Buechner, T. and Fonatsch, C.
British Journal of Haematology 100 : 521-533. 1 March 1998

Detection of hyperdiploid karyotypes (>50 chromosomes) in childhood acute lymphoblastic leukemia (ALL) using fluorescence in situ hybridization (FISH).
Ritterbach, J., Hiddemann, W., Beck, J.D., Schrappe, M., Janka-Schaub, G., Ludwig, W.D., Harbott, J. and Lampert, F.
Leukemia 12 : 427-433. 1 March 1998

A glucose-containing ether lipid (Glc-PAF) as an antiproliferative analogue of the platelet-activating factor.
Mickeleit, M., Wieder, T., Arnold, M., Geilen, C.C., Mulzer, J. and Reutter, W.
Angewandte Chemie International Edition 37 (3): 351-353. 16 February 1998

Detection of the DCC gene product in normal and malignant colorectal tissues and its relation to a codon 201 mutation.
Schmitt, C.A., Thaler, K.R., Wittig, B.M., Kaulen, H., Meyer Zum Bueschenfelde, K.H. and Dippold, W.G.
British Journal of Cancer 77 : 588-594. 1 February 1998

Expansion of autoreactive T cells in multiple sclerosis is independent of exogenous B7 costimulation.
Scholz, C., Patton, K.T., Anderson, D.E., Freeman, G.J. and Hafler, D.A.
Journal of Immunology 160 (3): 1532-1538. 1 February 1998

Meropenem monotherapy versus combination therapy with ceftazidime and amikacin for empirical treatment of febrile neutropenic patients.
Behre, G., Link, H., Maschmeyer, G., Meyer, P., Paaz, U., Wilhelm, M. and Hiddemann, W.
Annals of Hematology 76 : 73-80. 1 February 1998

Effective biomodulation by leucovorin of high-dose infusion fluorouracil given as a weekly 24-hour infusion: results of a randomized trial in patients with advanced colorectal cancer.
Koehne, C.H., Schoeffski, P., Wilke, H., Kaeufer, C., Andreesen, R., Ohl, U., Klaasen, U., Westerhausen, M., Hiddemann, W., Schott, G., Harstick, A., Bade, J., Horster, A., Schubert, U., Hecker, H., Doerken, B. and Schmoll, H.J.
Journal of Clinical Oncology 16 (2): 418-426. February 1998

A pilot study on intensive weekly 24-hour intra-arterial infusion with 5-fluorouracil and folinic acid for colorectal liver metastases.
Lorenz, M., Staib-Sebler, E., Gog, C., Petrowsky, H., Koehne, C.H. and Encke, A.
Oncology 55 : 53-58. 1 January 1998

Dendritic cells for somatic gene therapy.
Westermann, J., Aicher, A. and Pezzutto, A.
Recent Results in Cancer Research 144 : 70-77. 1 January 1998

Dendritic cells prevent CD95 mediated T lymphocyte death through costimulatory signals.
Daniel, P.T., Scholz, C., Westermann, J., Doerken, B. and Pezzutto, A.
Advances in Experimental Medicine and Biology 451 : 173-177. 1 January 1998

Ex vivo breast cancer cell purging by adenovirus- mediated cytosine deaminase gene transfer and short-term incubation with 5-Fluorocytosine completely prevents tumor growth after transplantation.
Wolff, G., Koerner, I., Schumacher, A., Arnold, W., Doerken, B. and Mapara, M.Y.
Human Gene Therapy 9 : 2277-2284. 1 January 1998

Immunophenotypic and clinical features of T-cell receptor gammadelta+ T-lineage acute lymphoblastic leukaemia.
Schott, G., Sperling, C., Schrappe, M., Ratei, R., Martin, M., Meyer, U., Riehm, H. and Ludwig, W.D.
British Journal of Haematology 101 : 753-755. 1 January 1998

Inhibition of CPP32 blocks surface IgM-mediated apoptosis and D4-GDI cleavage in human BL 60 Burkitt lymphoma cells.
Rickers, A., Brockstedt, E., Mapara, M.Y., Otto, A., Doerken, B. and Bommert, K.
European Journal of Immunology 28 : 296-304. 1 January 1998

Is continuous 24-Hour Infusion of 5-fluorouracil plus high-dose folinic acid effective in patients with progressive or recurrent colorectal cancer? A phase II study.
Hartmann, J.T., Koehne, C.H., Schmoll, H.J., Daikeler, T., Kanz, L. and Bokemeyer, C.
Oncology 55 : 320-325. 1 January 1998

Retroviral B7.1 gene transfer in cancer cells protects cytotoxic T cells from deletion by "veto" apoptosis.
Daniel, P.T., Kroidl, A., Cayeux, S., Scholz, C., Sturm, I., Blankenstein, T., Pezzutto, A. and Doerken, B.
Advances in Experimental Medicine and Biology 451 : 265-276. 1 January 1998

Retroviral interleukin-7 gene transfer into human dendritic cells enhances T cell activation.
Westermann, J., Aicher, A., Qin, Z., Cayeux, S., Daemen, K., Blankenstein, T., Doerken, B. and Pezzutto, A.
Gene Therapy 5 : 264-271. 1 January 1998

1997

Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells.
Bargou, R.C., Emmerich, F., Krappmann, D., Bommert, K., Mapara, M.Y., Arnold, W., Royer, H.D., Grinstein, E., Greiner, A., Scheidereit, C. and Doerken, B.
Journal of Clinical Investigation 100 (12): 2961-2969. 15 December 1997

Differential expression and functional behaviour of the ഠand ౠintegrin subunits in cytokine stimulated fibroblast-like cells derived from synovial tissue of rheumatoid arthritis and osteoarthritis in vitro.
Rinaldi, N., Weis, D., Brado, B., Schwarz-Eywill, M., Lukoschek, M., Pezzutto, A., Keilholz, U. and Barth, T.F.
Annals of the Rheumatic Diseases 56 : 729-736. 1 December 1997

Expression of a hypoglycosylated form of CD86 (B7-2) on human T cells with altered binding properties to CD28 and CTLA-4.
Hoellsberg, P., Scholz, C., Anderson, D.E., Greenfield, E.A., Kuchroo, V.K., Freeman, G.J. and Hafler, D.A.
Journal of Immunology 159 (10): 4799-4805. 15 November 1997

New insights into the biology of Philadelphia-chromosome-positive acute lymphoblastic leukaemia using a combination of May-Grunwald-Giemsa staining and fluorescence in situ hybridization techniques at the single cell level.
Haferlach, T., Winkemann, M., Ramm-Petersen, L., Meeder, M., Schoch, R., Weber-Matthiesen, K., Schlegelberger, B., Schoch, C., Ludwig, W.D., Hiddemann, W. and Loffler, H.
British Journal of Haematology 99 : 452-459. 1 November 1997

Verfahren zum Gentransfer in tierische Zellen.
Boettger, M., Arnold, W., Zaitsev, S.V. and Haberland, A.
DE19616645A1. 30 October 1997

Costimulatory signals through B7.1/CD28 prevent T cell apoptosis during target cell lysis.
Daniel, P.T., Kroidl, A., Cayeux, S., Bargou, R.C., Blankenstein, T. and Doerken, B.
Journal of Immunology 159 (8): 3808-3815. 15 October 1997

Role of alveolar macrophages in rapid elimination of adenovirus vectors administered to the epithelial surface of the respiratory tract.
Worgall, S., Leopold, P.L., Wolff, G., Ferris, B., Van Roijen, N. and Crystal, R.G.
Human Gene Therapy 8 (14): 1675-1684. 20 September 1997

Modulation of 5-fluorouracil with methotrexate and low-dose N-(phosphonacetyl)-L-aspartate (PALA) is inactive in advanced pancreatic carcinoma.
Harstrick, A., Kohne, C.H., Hiddemann, W., Preusser, P., Strumberg, D., Berns, T., Seeber, S., Wilke, H. and Schmoll, H.J.
Annals of Oncology 8 : 917-918. 1 September 1997

Retroviraler Vektor fuer den Gentransfer eines IL6-Antagonisten in humane haematopoetische Stammzellen.
Bargou, R., Baum, C. and Hoenemann, D.
DE19704979A1. 14 August 1997

Role of cranial radiotherapy for childhood T-cell acute lymphobalstic leukemia with high WBC count and good response to prednisone.
Conter, V., Schrappe, M., Arico, M., Reiter, A., Rizzari, C., Doerdelmann, M., Valsecchi, M.G., Zimmermann, M., Ludwig, W.D., Basso, G., Masera, G. and Riehm, H.
Journal of Clinical Oncology 15 (8): 2786-2791. August 1997

Lebendvakzine zur Behandlung von Tumorerkrankungen [Live vaccine for the treatment of tumour diseases].
T. Blankenstein, S. Cayeux.
EP0777499A1 ; EP0777499B1 ; WO9605866A2 ; WO9605866A3 ; US6,039,941. 11 June 1997

Treatment of brain metastases in patients with testicular cancer.
Bokemeyer, C., Nowak, P., Haupt, A., Metzner, B., Koehne, H., Hartmann, J.T., Kanz, L. and Schmoll, H.J.
Journal of Clinical Oncology 15 (4): 1449-1454. April 1997

Activation and activation-induced death of human tonsillar B cells and Burkitt lymphoma cells: lack of CD95 (Fas/APO-1) ligand expression and function.
Daniel, P.T., Oettinger, U., Mapara, M.Y., Bommert, K., Bargou, R.C. and Doerken, B.
European Journal of Immunology 27 : 1029-1034. 1 January 1997

Antimikrobielle Therapie bei Neutropenie.
Maschmeyer, G., Vogt, K., Hahn, H. and Doerken, B.
Deutsche Medizinische Wochenschrift 122 : 864-869. 1 January 1997

Differential CD95 expression and function in T and B lineage acute lymphoblastic leukemia cells.
Karawajew, L., Wuchter, C., Ruppert, V., Drexler, H., Gruss, H.J., Doerken, B. and Ludwig, W.D.
Leukemia 11 : 1245-1252. 1 January 1997

Enhancement of in vivo adenovirus-mediated gene transfer and expression by prior depletion of tissue macrophages in the target organ.
Wolff, G., Worgall, S., van Rooijen, N., Song, W.R., Harvey, B.G. and Crystal, R.G.
Journal of Virology 71 (1): 624-629. 1 January 1997

Expression of intercellular adhesion molecule 1 (ICAM-1) in childhood acute lymphoblastic leukemia: correlation with clinical features and outcome.
Mielcarek, M., Sperling, C., Schrappe, M., Meyer, U., Riehm, H. and Ludwig, W.D.
British Journal of Haematology 96 : 301-307. 1 January 1997

Expression of the stem cell factor receptor c-kit (CD117) in acute leukemias.
Sperling, C., Schwartz, S., Buechner, T., Thiel, E. and Ludwig, W.D.
Haematologica 82 : 617-621. 1 January 1997

Incidence and clinical relevance of TEL/AML1 fusion genes in children with acute lymphoblastic leukemia enrolled in the german and italian multicenter therapy trials.
Borkhardt, A., Cazzaniga, G., Viehmann, S., Valsecchi, M.G., Ludwig, W.D., Burci, L., Mangioni, S., Schrappe, M., Riehm, H., Lampert, F., Basso, G., Masera, G., Harbott, J. and Biondi, A.
Blood 90 : 571-577. 1 January 1997

Influence of gene modified (IL 7, IL 4, and B7) tumor cell vaccines on tumor antigen presentation.
Cayeux, S., Richter, G., Noffz, G., Doerken, B. and Blankenstein, T.
Journal of Immunology 158 : 2834-2841. 1 January 1997

Innate immune mechanisms dominate elimination of adenoviral vectors following in vivo administration.
Worgall, S., Wolff, G., Falck-Pedersen, E. and Crystal, R.G.
Human Gene Therapy 8 : 37-44. 1 January 1997

Lack of correlation between rejection of tumor cells co-expressing interleukin 2 and B7.1 and vaccine efficiency.
Cayeux, S., Richter, G., Becker, C., Beck, C., Aicher, A., Pezzutto, A., Doerken, B. and Blankenstein, T.
European Journal of Immunology 27 : 1657-1662. 1 January 1997

Liver associated toxicity of the hsv tk/gcv approach and adenoviral vectors.
Brand, K., Arnold, W., Bartels, T., Lieber, A., Kay, M.A., Strauss, M. and Doerken, B.
Cancer Gene Therapy 4 (1): 9-16. 1 January 1997

Modulation of 5-fluorouracil with methotrexate and low-dose N- (phosphonacetyl)-L-aspartate in patients with advanced colorectal cancer. results of a phase II study.
Koehne, C.H., Harstrick, A., Hiddemann, W., Schoeffski, P., Wilke, H., Bokemeyer, C., Doerken, B. and Schmoll, H.J.
European Journal of Cancer 33 : 1896-1899. 1 January 1997

Monitoring of tumor cell purging after highly efficient immunomagnetic selection of CD34 cells from leukapheresis products in breast cancer patients: comparision of immunocytochemical tumor cells staining and RT-PCR.
Mapara, M.Y., Koerner, I.J., Hildebrandt, M., Bargou, R.C., Krahl, D., Reichardt, P. and Doerken, B.
Blood 89 (1): 337-344. 1 January 1997

Morphological and cytochemical findings in 150 cases of T-lineage acute lymphoblastic leukemia in adults.
Gassmann, W., Loeffler, H., Thiel, E., Ludwig, W.D., Schwartz, S., Haferlach, T., Maurer, J., Rieder, H., Fonatsch, C., Goekbuget, N. and Hoelzer, D.
British Journal of Haematology 97 : 372-382. 1 January 1997

Nuclear localization and increased levels of transcription factor YB-1 in primary human breast cancers are associated with intrinsic MDR1 gene expression.
Bargou, R.C., Juerchott, K., Wagener, C., Bergmann, S., Metzner, S., Bommert, K., Mapara, M.Y., Winzer, K.J., Dietel, M., Doerken, B. and Royer, H.D.
Nature Medicine 3 : 447-450. 1 January 1997

Overexpression of the death-promoting gene bax-alpha sensitizes human BL-41 Burkitt lymphoma cells for surface IgM-mediated apoptosis.
Weinmann, P., Bommert, K., Mapara, M.Y., Doerken, B. and Bargou, R.C.
European Journal of Immunology 27 : 2466-2468. 1 January 1997

Prognostic significance of additional chromosome abnormalities in adult patients with philadelphia chromosome positive acute lymphoblastic leukaemia.
Rieder, H., Ludwig, W.D., Gassmann, W., Maurer, J., Janssen, J.W., Gokbuget, N., Schwartz, S., Thiel, E., Loeffler, H., Bartram, C.R., Hoelzer, D. and Fonatsch, C.
British Journal of Haematology 95 : 678-691. 1 January 1997

Reverse transcriptase-polymerase chain reaction (RT-PCR)-controlled immunomagnetic purging of breast cancer cells using the magnetic cell separation (MACS) system: a sensitive method for monitoring purging efficiency.
Hildebrandt, M., Mapara, M.Y., Koerner, I.J., Bargou, R.C., Moldenhauer, G. and Doerken, B.
Experimental Hematology 25 : 57-65. 1 January 1997

Successful retroviral mediated transduction of a receptor gene in human dendritic cells: feasibility of therapy with gene-modified antigen presenting cells.
Aicher, A., Westermann, J., Cayeux, S., Willimsky, G., Daemen, K., Blankenstein, T., Uckert, W., Doerken, B. and Pezzutto, A.
Experimental Hematology 25 : 39-44. 1 January 1997

The value of weekly high dose infusional 5-fluorouracil in the treatment of advanced colorectal cancer.
Koehne, C.H., Daniel, P.T. and Doerken, B.
Tumori 83, 1 : S56-S60. 1 January 1997

Tumor cell vaccines using genetically modified cells coexpressing cytokines and the T cell costimulatory molecule B7.
Cayeux, S., Doerken, B. and Blankenstein, T.
In: Concepts in Gene Therapy. de Gruyter, Berlin [u.a.], 487-503. 1 January 1997

1996

Myelodysplasia and acute myelogenous leukemia in Down's syndrome. A report of 40 children of the AML-BFM Study Group.
Creutzig, U., Ritter, J., Vormoor, J., Ludwig, W.D., Niemeyer, C., Reinisch, I., Stollmann-Gibbels, B., Zimmermann, M. and Harbott, J.
Leukemia 10 (11): 1677-1686. 1 November 1996

Clinical experiences with magnetic drug targeting: a phase I study with 4'-epidoxorubicin in 14 patients with advanced solid tumors.
Luebbe, A.S., Bergemann, C., Riess, H., Schriever, F., Reichardt, P., Possinger, K., Matthias, M., Doerken, B., Herrmann, F., Guertler, R., Hohenberger, P., Haas, N., Sohr, R., Sander, B., Lemke, A.J., Ohlendorf, D., Huhnt, W. and Huhn, D.
Cancer Research 56 (20): 4686-4693. 15 October 1996

Activation of human T cell lymphotropic virus type I-infected T cells is independent of B7 costimulation.
Scholz, C., Freeman, G.J., Greenfield, E.A., Hafler, D.A. and Hollsberg, P.
Journal of Immunology 157 (7): 2932-2938. 1 October 1996

Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in epstein-barr virus (EBV)-related lymphoma cell lines.
Weber-Nordt, R.M., Egen, C., Wehinger, J., Ludwig, W.D., Gouilleuxgruart, V., Mertelsmann, R. and Finke, J.
Blood 88 (3): 809-816. 1 August 1996

Induction of the death-promoting gene bax-alpha sensitizes cultured breast-cancer cells to drug-induced apoptosis.
Wagener, C., Bargou, R.C., Daniel, P.T., Bommert, K., Mapara, M.Y., Royer, H.D. and Doerken, B.
International Journal of Cancer 67 (1): 138-141. 3 July 1996

Monoclonal antibody WGM1 directed against proteinase 3: an immunohistochemical marker for naphthol ASD chloroacetate.
Braun, M.G., Csernok, E., Roegener-Schwarz, W., Ludwig, W.D., Mueller-Hermelink, H.K., Gross, W.L. and Feller, A.C.
Hematological Oncology 14 : 83-90. 1 June 1996

Overexpression of the death-promoting gene bax-alpha which is downregulated in breast cancer restores sensitivity to different apoptotic stimuli and reduces tumor growth in SCID mice.
Bargou, R.C., Wagener, C., Bommert, K., Mapara, M.Y., Daniel, P.T., Arnold, W., Dietel, M., Guski, H., Feller, A., Royer, H.D. and Doerken, B.
Journal of Clinical Investigation 97 (11): 2651-2659. 1 June 1996

Blocking of transcription factor E2F/DP by dominant-negative mutants in a normal breast epithelial cell line efficiently inhibits apoptosis and induces tumor growth in scid mice.
Bargou, R.C., Wagener, C., Bommert, K., Arnold, W., Daniel, P.T., Mapara, M.Y., Grinstein, E., Royer, H.D. and Doerken, B.
Journal of Experimental Medicine 183 (3): 1205-1213. 1 March 1996

Induction of cellular immunity in chimpanzees to human tumor associated antigen mucin by vaccination with MUC-1 cDNA-transfected Epstein-Barr virus-immortalized autologous B cells.
Pecher, G. and Finn, O.J.
Proceedings of the National Academy of Sciences of the United States of America 93 (4): 1699-1704. 20 February 1996

Clinical features and outcome of children with first marrow relapse of acute lymphoblastic leukemia expressing BCR-ABL fusion transcripts.
Beyermann, B., Agthe, A.G., Adams, H.P., Seeger, K., Linderkamp, C., Goetze, G., Ludwig, W.D. and Henze, G.
Blood 87 (4): 1532-1538. 15 February 1996

1H-NMR structural analysis of ethidium bromide complexation with self-complementary deoxytetranucleotides 5'-d(ApCpGpT), 5'-d(ApGpCpT), and 5'-d(TpGpCpA) in aqueous solution.
Davies, D.B., Karawajew, L. and Veselkov, A.N.
Biopolymers 38 (6): 745-757. 1 January 1996

Acute myeloid and T-cell acute lymphoblastic leukaemia with aberrant antigen expression exhibit similar TCRdelta gene rearrangements.
Schmidt, C.A., Przybylski, G., Tietze, A., Oettle, H., Siegert, W. and Ludwig, W.D.
British Journal of Haematology 92 (4): 929-936. 1 January 1996

Coexpression of interleukin-4 and B7.1 in murine tumor cells leads to improved tumor rejection and vaccine effect compared to single gene transfectants and a classical adjuvant.
Cayeux, S., Beck, C., Doerken, B. and Blankenstein, T.
Human Gene Therapy 7 (4): 525-529. 1 January 1996

Development of an enzyme immunoassay for the measurement of human tumour necrosis factor-alpha (hTNF-alpha) using bispecific antibodies to hTNF-alpha and horseradish peroxidase.
Berkova, N., Karawajew, L., Korobko, V., Behrsing, O., Micheel, B., Shamborant, O., Stukatcheva, E. and Shingarova, L.
Biotechnology and Applied Biochemistry 23 Part 2 : 163-171. 1 January 1996

Downegulation of IL-10 secretion and enhanced antigen presenting abilities following HTLV-I infection of T-cells.
Scholz, C., Hafler, D.A. and Hoellsberg, P.
Journal of Neuroscience Research 45 : 786-794. 1 January 1996

Effects of FLT3 ligand on human leukemia cells. I. proliferative response of myeloid leukemia cells.
Dehmel, U., Zaborski, M., Meierhoff, G., Rosnet, O., Birnbaum, D., Ludwig, W.D., Quentmeier, H. and Drexler, H.G.
Leukemia 10 (2): 261-270. 1 January 1996

Expression of the receptor MPL and proliferative effects of its ligand thrombopoietin on human leukemia cells.
Quentmeier, H., Zaborski, M., Graf, G., Ludwig, W.D. and Drexler, H.G.
Leukemia 10 : 297-310. 1 January 1996

HMG1 - Effected gene transfer using cell cultures and tissue explants xenografted in immunodeficient mice.
Boettger, M., Arnold, W., Zaitsev, S., Vorob'ev, V.I., Haberland, A. and Schimke, I.
In: Immunodeficient Animals: Models in Cancer Research. Contributions to Oncology ; 51 . Karger, Basel, 36-40. 1 January 1996

High level nuclear NF-kB and Oct-2 is a common feature of cultured Hodgkin/Sternberg cells.
Bargou, R.C., Leng, C., Krappmann, D., Emmerich, F., Mapara, M.Y., Bommert, K., Royer, H.D., Scheidereit, C. and Doerken, B.
Blood 87 (10): 4340-4347. 1 January 1996

Improved outcome in adult b cell acute lymphoblastic leukemia.
Hoelzer, D., Ludwig, W.D., Thiel, E., Gassmann, W., Loeffler, H., Fonatsch, C., Rieder, H., Heil, G., Heinze, B., Arnold, R., Hossfeld, D., Buechner, T., Koch, P., Freund, M., Hiddemann, W., Maschmeyer, G., Heyll, A., Aul, C., Faak, T., Kuse, R., Ittel, T.H., Gramatzki, M., Diedrich, H., Kolbe, K., Fuhr, H.G., Fischer, K., Schadeck-Gressel, C., Weiss, A., Strohscheer, I., Metzner, B., Fabry, U., Gokbuget, N., Volkers, B., Messerer, D. and Ueberla, K.
Blood 87 (2): 495-508. 1 January 1996

Secondary acute leukaemias with 11q23 rearrangement: clinical, cytogenetic, fish and fiction studies.
Zhao, Y.M., Poetsch, M., Weber-Matthiesen, K., Rohde, G., Winkemann, M., Haferlach, T., Gassmann, W., Ludwig, W.D., Grote, W., Loeffler, H. and Schlegelberger, B.
British Journal of Haematology 92 (3): 673-680. 1 January 1996

The dead end of 5-fluorouracil double modulation and promise of continuous infusion schedules in the treatment of metastatic colorectal cancer.
Koehne, C.H., Wilke, H., Schoeffski, P. and Schmoll, H.J.
Journal of Infusional Chemotherapy 6 : 206-210. 1 January 1996

Xenotransplantation of a novel hodgkin cell line HD-MyZ into SCID mice.
Bargou, R.C., Mapara, M.Y., Arnold, W., Daniel, P.T. and Doerken, B.
In: Immunodeficient Animals: Models in Cancer Research. Contributions to Oncology ; 51 . Karger, Basel, 187-192. 1 January 1996

"Sero-switch" adenovirus-mediated in vivo gene transfer: circumvention of anti-adenovirus humoral immune defenses against repeat adenovirus vector administration by changing the adenovirus serotype.
Mastrangeli, A., Harvey, B.G., Yao, J., Wolff, G., Kovesdi, I., Crystal, R.G. and Falck-Pedersen, E.
Human Gene Therapy 7 (1): 79-87. January 1996

1995

Clinical significance of surface antigen expression in children with acute myeloid leukemia: results of study AML-BFM-87.
Creutzig, U., Harbott, J., Sperling, C., Ritter, J., Zimmermann, M., Loeffler, H., Riehm, H., Schellong, G. and Ludwig, W.D.
Blood 86 (8): 3097-3108. 1 October 1995

The receptor tyrosine kinase p185HER2 is expressed on a subset of B-lymphoid blasts from patients with acute lymphoblastic leukemia and chronic myelogenous leukemia.
Buehring, H.J., Sures, I., Jallal, B., Weiss, F.U., Busch, F.W., Ludwig, W.D., Handgretinger, R., Waller, H.D. and Ullrich, A.
Blood 86 (5): 1916-1923. 1 September 1995

Involvement of NAK-1, the human nur77 homologue, in surface IgM-mediated apoptosis in Burkitt lymphoma cell line BL41.
Mapara, M.Y., Weinmann, P., Bommert, K., Daniel, P.T., Bargou, R.C. and Doerken, B.
European Journal of Immunology 25 (9): 2506-2510. September 1995

G protein subunit G alpha16 expression is restricted to progenitor B-cells during human B-cell differentiation.
Mapara, M.Y., Bommert, K., Bargou, R.C., Leng, C., Beck, C., Ludwig, W.D., Gierschik, P. and Doerken, B.
Blood 85 (7): 1836-1842. 1 April 1995

Acute leukemia coexpressing myeloid, B- and T-lineage associated markers: multiparameter analysis of criteria defining lineage commitment and maturational stage in a case of undifferentiated leukemia.
Meckenstock, G., Heyll, A., Schneider, E.M., Hildebrandt, B., Runde, V., Aul, C., Bartram, C.R., Ludwig, W.D. and Schneider, W.
Leukemia 9 : 260-264. 1 January 1995

Aerosol amphotericin b inhalations for prevention of invasive pulmonary aspergillosis in neutropenic cancer patients.
Behre, G.F., Schwartz, S., Lenz, K., Ludwig, W.D., Schilling, E., Heinemann, V., Link, H., Boenisch, O., Treder, W., Siegert, W., Wandt, H., Trittin, A., Hiddemann, W. and Beyer, J.
Annals of Hematology 71 (6): 287-291. 1 January 1995

An effective, direct immunomagnetic procedure for purging acute lymphoblastic leukemia cells from human bone marrow.
Wang, M.Y., Fostad, O., Ludwig, W.D., Bentsson, M., Totterman, T., Funderud, S., Martin, H. and Kvalheim, G.
Pathology and Oncology Research 1 : 32-37. 1 January 1995

Analysis of a family of cyclin-dependent kinase inhibitors: p15/mts2/ink4b, p16/mts1/ink4a, and p18 genes in acute lymphoblastic leukemia of childhood.
Takeuchi, S., Bartram, C.R., Seriu, T., Miller, C.W., Tobler, A., Janssen, J.W., Reiter, A., Ludwig, W.D., Zimmermann, M., Schwaller, J., Lee, E., Miyoshi, I. and Koeffler, H.P.
Blood 86 (2): 755-760. 1 January 1995

Clinical, morphologic, cytogenetic and prognostic implications of CD34 expression in childhood and adult de novo AML.
Sperling, C., Buechner, T., Creutzig, U., Ritter, J., Harbott, J., Fonatsch, C., Sauerland, C., Mielcarek, M., Maschmeyer, G., Loeffler, H. and Ludwig, W.D.
Leukemia & Lymphoma 17 : 417-426. 1 January 1995

Expression of the bcl-2 gene family in normal and malignant breast tissue: low bax-alpha expresssion in tumor cells correlates with resistance to apoptosis.
Bargou, R.C., Daniel, P.T., Mapara, M.Y., Bommert, K., Wagener, C., Kallinich, B., Royer, H.D. and Doerken, B.
International Journal of Cancer 60 : 854-859. 1 January 1995

Failure of orally administered dipyridamole to enhance the antineoplastic activity of fluorouracil in combination with leucovorin in patients with advanced colorectal cancer: a prospective randomized trial.
Koehne, C.H., Hiddemann, W., Schueller, J., Weiss, J., Lohrmann, H.P., Schmitz-Huebner, U., Bodenstein, H., Schoeber, C., Wilke, H., Grem, J. and Schmoll, H.J.
Journal of Clinical Oncology 13 : 1201-1208. 1 January 1995

Induction of Bax-alpha precedes apoptosis in a human B lymphoma cell line: potential role of the bcl-2 gene family in surface IgM-mediated apoptosis.
Bargou, R.C., Bommert, K., Weinmann, P., Daniel, P.T., Wagener, C., Mapara, M.Y. and Doerken, B.
European Journal of Immunology 25 : 770-775. 1 January 1995

Interferon-alpha does not improve the antineoplastic efficacy of highdose infusional 5-fluorouracil plus folinic acid in advanced colorectal cancer: First results of a randomized multicenter study by the Association of Medical Oncology of the German Cancer Society (AIO).
Koehne, C.H., Wilke, H., Hecker, H., Schoeffski, P., Kaeufer, C., Rauschecker, H., Andreesen, R., Ohl, U., Lange, H.J., Klaassen, U., Westerhausen, M., Hiddemann, W., Hennemann, B., Schott, G., Bade, J., Strohmeyer, G., Harstrick, A., Schubert, U., Bokemeyer, C. and Schmoll, H.J.
Annals of Oncology 6 : 461-466. 1 January 1995

Intrapericardial application of mitoxantrone for treatment of malignant pericardial effusion.
Lentzsch, S., Reichardt, P., Guertler, R. and Doerken, B.
Onkologie 17 : 504-507. 1 January 1995

Modulation of cytokine patterns of human autoreactive T cell clones by a single amino acid substitution of their peptide ligand.
Windhagen, A., Scholz, C., Hoellsberg, P., Fukaura, H., Sette, A. and Hafler, D.A.
Immunity 2 : 373-380. 1 January 1995