2024
Mutations in CLCN6 as a novel genetic cause of neuronal ceroid lipofuscinosis in patients and a murine model.
He, H., Cao, X., He, F., Zhang, W., Wang, X., Peng, P., Xie, C., Yin, F., Li, D., Li, J., Wang, M., Klüssendorf, M., Jentsch, T.J., Stauber, T. and Peng, J.
Annals of Neurology 96
(3): 608-624.
September 2024
Gain-of-function variants in CLCN7 cause hypopigmentation and lysosomal storage disease.
Polovitskaya, M.M., Rana, T., Ullrich, K., Murko, S., Bierhals, T., Vogt, G., Stauber, T., Kubisch, C., Santer, R. and Jentsch, T.J.
Journal of Biological Chemistry 300
(7): 107437.
July 2024
LRRC8/VRAC volume-regulated anion channels are crucial for hearing.
Knecht, D.A., Zeziulia, M., Bhavsar, M., Puchkov, D., Maier, H. and Jentsch, T.J.
Journal of Biological Chemistry 300
(7): 107436.
July 2024
KCNQ5 controls perivascular adipose tissue–mediated vasodilation.
Tsvetkov, D., Schleifenbaum, J., Wang, Y., Kassmann, M., Polovitskaya, M.M., Ali, M., Schütze, S., Rothe, M., Luft, F.C., Jentsch, T.J. and Gollasch, M.
Hypertension 81
(3): 561-571.
March 2024
2023
Molecular basis of ClC-6 function and its impairment in human disease.
Zhang, B., Zhang, S., Polovitskaya, M.M., Yi, J., Ye, B., Li, R., Huang, X., Yin, J., Neuens, S., Balfroid, T., Soblet, J., Vens, D., Aeby, A., Li, X., Cai, J., Song, Y., Li, Y., Tartaglia, M., Li, Y., Jentsch, T.J., Yang, M. and Liu, Z.
Science Advances 9
(41): eadg4479.
13 October 2023
Structural insights into anion selectivity and activation mechanism of LRRC8 volume-regulated anion channels.
Liu, H., Polovitskaya, M.M., Yang, L., Li, M., Li, H., Han, Z., Wu, J., Zhang, Q., Jentsch, T.J. and Liao, J.
Cell Reports 42
(8): 112926.
29 August 2023
ClC-7 drives intraphagosomal chloride accumulation to support hydrolase activity and phagosome resolution.
Wu, J.Z., Zeziulia, M., Kwon, W., Jentsch, T.J., Grinstein, S. and Freeman, S.A.
Journal of Cell Biology 222
(6): e202208155.
5 June 2023
Neuron-oligodendrocyte potassium shuttling at nodes of Ranvier protects against inflammatory demyelination.
Kapell, H., Fazio, L., Dyckow, J., Schwarz, S., Cruz-Herranz, A., Campos, J., Mayer, C., D Este, E., Möbius, W., Cordano, C., Pröbstel, A.K., Gharagozloo, M., Zulji, A., Narayanan Naik, V., Delank, A.K., Cerina, M., Müntefering, T., Lerma-Martin, C., Sonner, J.K., Sin, J.H., Disse, P., Rychlik, N., Sabeur, K., Chavali, M., Srivastava, R., Heidenreich, M., Fitzgerald, K.C., Seebohm, G., Stadelmann, C., Hemmer, B., Platten, M., Jentsch, T.J., Engelhardt, M., Budde, T., Nave, K.A., Calabresi, P.A., Friese, M.A., Green, A.J., Acuna, C., Rowitch, D.H., Meuth, S.G. and Schirmer, L.
Journal of Clinical Investigation 133
(7): e164223.
3 April 2023
SLC26A1 is a major determinant of sulfate homeostasis in humans.
Pfau, A., López-Cayuqueo, K.I., Scherer, N., Wuttke, M., Wernstedt, A., González Fassrainer, D., Smith, D.E., van de Kamp, J.M., Ziegeler, K., Eckardt, K.U., Luft, F.C., Aronson, P.S., Köttgen, A., Jentsch, T.J. and Knauf, F.
Journal of Clinical Investigation 133
(3): e161849.
1 February 2023
2022
Renal deletion of LRRC8/VRAC channels induces proximal tubulopathy.
López-Cayuqueo, K.I., Planells-Cases, R., Pietzke, M., Oliveras, A., Kempa, S., Bachmann, S. and Jentsch, T.J.
Journal of the American Society of Nephrology 33
(8): 1528-1545.
August 2022
Proton-gated anion transport governs macropinosome shrinkage.
Zeziulia, M., Blin, S., Schmitt, F.W., Lehmann, M. and Jentsch, T.J.
Nature Cell Biology 24
(6): 885-895.
June 2022
Gating choreography and mechanism of the human proton-activated chloride channel ASOR.
Wang, C., Polovitskaya, M.M., Delgado, B.D., Jentsch, T.J. and Long, S.B.
Science Advances 8
(5): eabm3942.
2 February 2022
2021
Place fields of single spikes in hippocampus involve Kcnq3 channel-dependent entrainment of complex spike bursts.
Gao, X., Bender, F., Soh, H., Chen, C., Altafi, M., Schütze, S., Heidenreich, M., Gorbati, M., Corbu, M.A., Carus-Cadavieco, M., Korotkova, T., Tzingounis, A.V., Jentsch, T.J. and Ponomarenko, A.
Nature Communications 12
(1): 4801.
10 August 2021
Unique variants in CLCN3, encoding an endosomal anion/proton exchanger, underlie a spectrum of neurodevelopmental disorders.
Duncan, A.R., Polovitskaya, M.M., Gaitán-Peñas, H., Bertelli, S., VanNoy, G.E., Grant, P.E., O'Donnell-Luria, A., Valivullah, Z., Lovgren, A.K., England, E.M., Agolini, E., Madden, J.A., Schmitz-Abe, K., Kritzer, A., Hawley, P., Novelli, A., Alfieri, P., Colafati, G.S., Wieczorek, D., Platzer, K., Luppe, J., Koch-Hogrebe, M., Abou Jamra, R., Neira-Fresneda, J., Lehman, A., Boerkoel, C.F., Seath, K., Clarke, L., van Ierland, Y., Argilli, E., Sherr, E.H., Maiorana, A., Diel, T., Hempel, M., Bierhals, T., Estévez, R., Jentsch, T.J., Pusch, M. and Agrawal, P.B.
American Journal of Human Genetics 108
(8): 1450-1465.
5 August 2021
Cellular basis of ClC-2 Cl(-) channel-related brain and testis pathologies.
Göppner, C., Soria, A.H., Hoegg-Beiler, M.B. and Jentsch, T.J.
Journal of Biological Chemistry 296
: 100074.
4 January 2021
Cl(-) channels and Cl(-)/H(+) exchangers.
Ullrich, F. and Jentsch, T.J.
In:
Encyclopedia of Molecular Pharmacology : Third Edition.
Springer, Cham, 470-477.
ISBN 978-3-030-57400-0
2021
2020
A recurrent gain-of-function mutation in CLCN6, encoding the ClC-6 Cl-/H+-exchanger, causes early-onset neurodegeneration.
Polovitskaya, M.M., Barbini, C., Martinelli, D., Harms, F.L., Cole, F.S., Calligari, P., Bocchinfuso, G., Stella, L., Ciolfi, A., Niceta, M., Rizza, T., Shinawi, M., Sisco, K., Johannsen, J., Denecke, J., Carrozzo, R., Wegner, D.J., Kutsche, K., Tartaglia, M. and Jentsch, T.J.
American Journal of Human Genetics 107
(6): 1062-1077.
3 December 2020
Transfer of cGAMP into bystander cells via LRRC8 volume-regulated anion channels augments STING-mediated interferon responses and anti-viral immunity.
Zhou, C., Chen, X., Planells-Cases, R., Chu, J., Wang, L., Cao, L., Li, Z., López-Cayuqueo, K.I., Xie, Y., Ye, S., Wang, X., Ullrich, F., Ma, S., Fang, Y., Zhang, X., Qian, Z., Liang, X., Cai, S.Q., Jiang, Z., Zhou, D., Leng, Q., Xiao, T.S., Lan, K., Yang, Ji., Li, H., Peng, C., Qiu, Z., Jentsch, T.J. and Xiao, H.
Immunity 52
(5): 767-781.
19 May 2020
Cryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation.
Nakamura, R., Numata, T., Kasuya, G., Yokoyama, T., Nishizawa, T., Kusakizako, T., Kato, T., Hagino, T., Dohmae, N., Inoue, M., Watanabe, K., Ichijo, H., Kikkawa, M., Shirouzu, M., Jentsch, T.J., Ishitani, R., Okada, Y. and Nureki, O.
Communications Biology 3
(1): 240.
15 May 2020
Uncoupling endosomal CLC chloride/proton exchange causes severe neurodegeneration.
Weinert, S., Gimber, N., Deuschel, D., Stuhlmann, T., Puchkov, D., Farsi, Z., Ludwig, C.F., Novarino, G., López-Cayuqueo, K.I., Planells-Cases, R. and Jentsch, T.J.
EMBO Journal 39
(9): e103358.
4 May 2020
Chloride transport across the lysosomal membrane.
Saha, S., Blessing, A. and Jentsch, T.J.
In:
Ion and Molecule Transport in Lysosomes.
CRC Press, Boca Raton, 19-44.
ISBN 9781351361132
2020
Cl(-) channels and Cl(-)/H(+) exchangers.
Ullrich, F. and Jentsch, T.J.
In:
Encyclopedia of Molecular Pharmacology.
Springer, Cham, 1-8.
ISBN 978-3-030-21573-6
2020
2019
Comparison of zebrafish and mice knockouts for Megalencephalic Leukoencephalopathy proteins indicates that GlialCAM/MLC1 forms a functional unit.
Pérez-Rius, C., Folgueira, M., Elorza-Vidal, X., Alia, A., Hoegg-Beiler, M.B., Eeza, M.N.H., Díaz, M.L., Nunes, V., Barrallo-Gimeno, A. and Estévez, R.
Orphanet Journal of Rare Diseases 14
(1): 268.
21 November 2019
Pathogenesis of hypertension in a mouse model for human CLCN2 related hyperaldosteronism.
Göppner, C., Orozco, I.J., Hoegg-Beiler, M.B., Soria, A.H., Hübner, C.A., Fernandes-Rosa, F.L., Boulkroun, S., Zennaro, M.C. and Jentsch, T.J.
Nature Communications 10
(1): 4678.
15 October 2019
Identification of TMEM206 proteins as pore of PAORAC/ASOR acid-sensitive chloride channels.
Ullrich, F., Blin, S., Lazarow, K., Daubitz, T., von Kries, J.P. and Jentsch, T.J.
eLife 8
: e49187.
18 July 2019
Lysosomal proteome analysis reveals that CLN3-defective cells have multiple enzyme deficiencies associated with changes in intracellular trafficking.
Schmidtke, C., Tiede, S., Thelen, M., Käkelä, R., Jabs, S., Makrypidi, G., Sylvester, M., Schweizer, M., Braren, I., Brocke-Ahmadinejad, N., Cotman, S.L., Schulz, A., Gieselmann, V. and Braulke, T.
Journal of Biological Chemistry 294
(24): 9592-9604.
14 June 2019
2018
LRRC8 amino-termini influence pore properties and gating of volume-regulated VRAC anion channels.
Zhou, P., Polovitskaya, M.M. and Jentsch, T.J.
Journal of Biological Chemistry 293
(35): 13440-13451.
31 August 2018
LRRC8/VRAC anion channels are required for late stages of spermatid development in mice.
Lück, J.C., Puchkov, D., Ullrich, F. and Jentsch, T.J.
Journal of Biological Chemistry 293
(30): 11796-11808.
27 July 2018
CLC chloride channels and transporters: structure, function, physiology, and disease.
Jentsch, T.J. and Pusch, M.
Physiological Reviews 98
(3): 1493-1590.
July 2018
Ca(2+)-activated Cl(-) currents in the murine vomeronasal organ enhance neuronal spiking but are dispensable for male-male aggression.
Münch, J., Billig, G., Huebner, C.A., Leinders-Zufall, T., Zufall, F. and Jentsch, T.J.
Journal of Biological Chemistry 293
(26): 10392-10403.
29 June 2018
Intestinal electrolyte and fluid secretion: a model in trouble?
Cid, L.P., Jentsch, T.J. and Sepúlveda, F.V.
Journal of Physiology 596
(12): 2465-2466.
15 June 2018
LRRC8/VRAC anion channels enhance β-cell glucose sensing and insulin secretion.
Stuhlmann, T., Planells-Cases, R. and Jentsch, T.J.
Nature Communications 9
(1): 1974.
17 May 2018
A gain-of-function mutation in the CLCN2 chloride channel gene causes primary aldosteronism.
Fernandes-Rosa, F.L., Daniil, G., Orozco, I.J., Göppner, C., El Zein, R., Jain, V., Boulkroun, S., Jeunemaitre, X., Amar, L., Lefebvre, H., Schwarzmayr, T., Strom, T.M., Jentsch, T.J. and Zennaro, M.C.
Nature Genetics 50
(3): 355-361.
March 2018
K(2P) TASK-2 and KCNQ1/KCNE3 K(+) channels are major players contributing to intestinal anion and fluid secretion.
Julio-Kalajzić, F., Villanueva, S., Burgos, J., Ojeda, M., Cid, L.P., Jentsch, T.J. and Sepúlveda, F.V.
Journal of Physiology 596
(3): 393-407.
1 February 2018
De novo and inherited mutations in the X-linked gene CLCN4 are associated with syndromic intellectual disability and behavior and seizure disorders in males and females.
Palmer, E.E., Stuhlmann, T., Weinert, S., Haan, E., Van Esch, H., Holvoet, M., Boyle, J., Leffler, M., Raynaud, M., Moraine, C., van Bokhoven, H., Kleefstra, T., Kahrizi, K., Najmabadi, H., Ropers, H.H., Delgado, M.R., Sirsi, D., Golla, S., Sommer, A., Pietryga, M.P., Chung, W.K., Wynn, J., Rohena, L., Bernardo, E., Hamlin, D., Faux, B.M., Grange, D.K., Manwaring, L., Tolmie, J., Joss, S., Cobben, J.M., Duijkers, F.A.M., Goehringer, J.M., Challman, T.D., Hennig, F., Fischer, U., Grimme, A., Suckow, V., Musante, L., Nicholl, J., Shaw, M., Lodh, S.P., Niu, Z., Rosenfeld, J.A., Stankiewicz, P., Jentsch, T.J., Gecz, J., Field, M. and Kalscheuer, V.M.
Molecular Psychiatry 23
(2): 222-230.
February 2018
2017
Loss of the Na(+)/H(+) exchanger NHE8 causes male infertility in mice by disrupting acrosome formation.
Oberheide, K., Puchkov, D. and Jentsch, T.J.
Journal of Biological Chemistry 292
(26): 10845-10854.
30 June 2017
Disruption of the vacuolar-type H(+)-ATPase complex in liver causes MTORC1-independent accumulation of autophagic vacuoles and lysosomes.
Kissing, S., Rudnik, S., Damme, M., Luellmann-Rauch, R., Ichihara, A., Kornak, U., Eskelinen, E.L., Jabs, S., Heeren, J., De Brabander, J.K., Haas, A. and Saftig, P.
Autophagy 13
(4): 670-685.
April 2017
Selective transport of neurotransmitters and modulators by distinct volume-regulated LRRC8 anion channels.
Lutter, D., Ullrich, F., Lueck, J.C., Kempa, S. and Jentsch, T.J.
Journal of Cell Science 130
(6): 1122-1133.
15 March 2017
The ClC-K2 chloride channel is critical for salt handling in the distal nephron.
Hennings, J.C., Andrini, O., Picard, N., Paulais, M., Huebner, A.K., Lopez Cayuqueo, I.K., Bignon, Y., Keck, M., Cornière, N., Böhm, D., Jentsch, T.J., Chambrey, R., Teulon, J., Hübner, C.A. and Eladari, D.
Journal of the American Society of Nephrology 28
(1): 209-217.
January 2017
2016
Inactivation and anion selectivity of volume-regulated VRAC channels depend on carboxy-terminal residues of the first extracellular loop.
Ullrich, F., Reincke, S.M., Voss, F.K., Stauber, T. and Jentsch, T.J.
Journal of Biological Chemistry 291
(33): 17040-17048.
12 August 2016
Disruption of Kcc2-dependent inhibition of olfactory bulb output neurons suggests its importance in odour discrimination.
Gödde, K., Gschwend, O., Puchkov, D., Pfeffer, C.K., Carleton, A. and Jentsch, T.J.
Nature Communications 7
: 12043.
8 July 2016
Lysosomal dysfunction caused by cellular accumulation of silica nanoparticles.
Schuetz, I., Lopez-Hernandez, T., Gao, Q., Puchkov, D., Jabs, S., Nordmeyer, D., Schmudde, M., Ruehl, E., Graf, C.M. and Haucke, V.
Journal of Biological Chemistry 291
(27): 14170-14184.
1 July 2016
VRACs and other ion channels and transporters in the regulation of cell volume and beyond.
Jentsch, T.J.
Nature Reviews Molecular Cell Biology 17
(5): 293-307.
May 2016
KCNQ potassium channels modulate sensitivity of skin D-hair mechanoreceptors.
Schütze, S., Orozco, I.J. and Jentsch, T.J.
Journal of Biological Chemistry 291
(11): 5566-5575.
11 March 2016
VRAC: molecular identification as LRRC8 heteromers with differential functions.
Jentsch, T.J., Lutter, D., Planells-Cases, R., Ullrich, F. and Voss, F.K.
Pflugers Archiv 468
(3): 385-393.
March 2016
X-exome sequencing of 405 unresolved families identifies seven novel intellectual disability genes.
Hu, H., Haas, S.A., Chelly, J., Van Esch, H., Raynaud, M., de Brouwer, A.P.M., Weinert, S., Froyen, G., Frints, S.G.M., Laumonnier, F., Zemojtel, T., Love, M.I., Richard, H., Emde, A.K., Bienek, M., Jensen, C., Hambrock, M., Fischer, U., Langnick, C., Feldkamp, M., Wissink-Lindhout, W., Lebrun, N., Castelnau, L., Rucci, J., Montjean, R., Dorseuil, O., Billuart, P., Stuhlmann, T., Shaw, M., Corbett, M.A., Gardner, A., Willis-Owen, S., Tan, C., Friend, K.L., Belet, S., van Roozendaal, K.E.P., Jimenez-Pocquet, M., Moizard, M.P., Ronce, N., Sun, R., O'Keeffe, S., Chenna, R., van Bömmel, A., Goeke, J., Hackett, A., Field, M., Christie, L., Boyle, J., Haan, E., Nelson, J., Turner, G., Baynam, G., Gillessen-Kaesbach, G., Mueller, U., Steinberger, D., Budny, B., Badura-Stronka, M., Latos-Bieleńska, A., Ousager, L.B., Wieacker, P., Rodríguez Criado, G., Bondeson, M.L., Annerén, G., Dufke, A., Cohen, M., Van Maldergem, L., Vincent-Delorme, C., Echenne, B., Simon-Bouy, B., Kleefstra, T., Willemsen, M., Fryns, J.P., Devriendt, K., Ullmann, R., Vingron, M., Wrogemann, K., Wienker, T.F., Tzschach, A., van Bokhoven, H., Gecz, J., Jentsch, T.J., Chen, W., Ropers, H.H. and Kalscheuer, V.M.
Molecular Psychiatry 21
(1): 133-148.
January 2016
2015
Optogenetic acidification of synaptic vesicles and lysosomes.
Rost, B.R., Schneider, F., Grauel, M.K., Wozny, C., Bentz, C.G., Blessing, A., Rosenmund, T., Jentsch, T.J., Schmitz, D., Hegemann, P. and Rosenmund, C.
Nature Neuroscience 18
(12): 1845-1852.
December 2015
Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt-based anti-cancer drugs.
Planells-Cases, R., Lutter, D., Guyader, C., Gerhards, N.M., Ullrich, F., Elger, D.A., Kucukosmanoglu, A., Xu, G., Voss, F.K., Reincke, S.M., Stauber, T., Blomen, V.A., Vis, D.J., Wessels, L.F., Brummelkamp, T.R., Borst, P., Rottenberg, S. and Jentsch, T.J.
EMBO Journal 34
(24): 2993-3008.
December 2015
Discovery of CLC transport proteins: cloning, structure, function and pathophysiology.
Jentsch, T.J.
Journal of Physiology 593
(18): 4091-4109.
15 September 2015
In vivo evidence for lysosome depletion and impaired autophagic clearance in hereditary spastic paraplegia type SPG11.
Varga, R.E., Khundadze, M., Damme, M., Nietzsche, S., Hoffmann, B., Stauber, T., Koch, N., Hennings, J.C., Franzka, P., Huebner, A.K., Kessels, M.M., Biskup, C., Jentsch, T.J., Qualmann, B., Braulke, T., Kurth, I., Beetz, C. and Hübner, C.A.
PLoS Genetics 11
(8): e1005454.
18 August 2015
Departure gate of acidic Ca(2+) confirmed.
Jentsch, T.J., Hoegg-Beiler, M.B. and Vogt, J.
EMBO Journal 34
(13): 1737-1739.
2 July 2015
KCNQ5 K(+) channels control hippocampal synaptic inhibition and fast network oscillations.
Fidzinski, P., Korotkova, T., Heidenreich, M., Maier, N., Schuetze, S., Kobler, O., Zuschratter, W., Schmitz, D., Ponomarenko, A. and Jentsch, T.J.
Nature Communications 6
: 6254.
4 February 2015
2014
Stretch-activation of angiotensin II type 1a receptors contributes to the myogenic response of mouse mesenteric and renal arteries.
Schleifenbaum, J., Kassmann, M., Szijártó, I.A., Hercule, H.C., Tano, J.Y., Weinert, S., Heidenreich, M., Pathan, A.R., Anistan, Y.M., Alenina, N., Rusch, N.J., Bader, M., Jentsch, T.J. and Gollasch, M.
Circulation Research 115
(2): 263-272.
7 July 2014
Transport activity and presence of ClC-7/Ostm1 complex account for different cellular functions.
Weinert, S., Jabs, S., Hohensee, S., Chan, W.L., Kornak, U. and Jentsch, T.J.
EMBO Reports 15
(7): 784-791.
1 July 2014
Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC.
Voss, F.K., Ullrich, F., Muench, J., Lazarow, K., Lutter, D., Mah, N., Andrade-Navarro, M.A., von Kries, J.P., Stauber, T. and Jentsch, T.J.
Science 344
(6184): 634-638.
9 May 2014
CLCN7 and TCIRG1 mutations differentially affect bone matrix mineralization in osteopetrotic individuals.
Barvencik, F., Kurth, I., Koehne, T., Stauber, T., Zustin, J., Tsiakas, K., Ludwig, C.F., Beil, F.T., Pestka, J.M., Hahn, M., Santer, R., Supanchart, C., Kornak, U., Del Fattore, A., Jentsch, T., Teti, A., Schulz, A., Schinke, T. and Amling, M.
Journal of Bone and Mineral Research 29
(4): 982-991.
April 2014
Disrupting MLC1 and GlialCAM and ClC-2 interactions in leukodystrophy entails glial chloride channel dysfunction.
Hoegg-Beiler, M.B., Sirisi, S., Orozco, I.J., Ferrer, I., Hohensee, S., Auberson, M., Goedde, K., Vilches, C., de Heredia, M.L., Nunes, V., Estévez, R. and Jentsch, T.J.
Nature Communications 5
: 3475.
19 March 2014
A missense mutation accelerating the gating of the lysosomal Cl(-)/H(+)-exchanger ClC-7/Ostm1 causes osteopetrosis with gingival hamartomas in cattle.
Sartelet, A., Stauber, T., Coppieters, W., Ludwig, C.F., Fasquelle, C., Druet, T., Zhang, Z., Ahariz, N., Cambisano, N., Jentsch, T.J. and Charlier, C.
Disease Models & Mechanisms 7
(1): 119-128.
January 2014
ClC-7 expression levels critically regulate bone turnover, but not gastric acid secretion.
Supanchart, C., Wartosch, L., Schlack, C., Kühnisch, J., Giehl, M., Felsenberg, D., Fuhrmann, J.C., de Vernejoul, M.C., Jentsch, T.J. and Kornak, U.
Bone 58
: 92-102.
January 2014
2013
Common gating of both CLC subunits underlies voltage-dependent activation of the 2Cl(-)/1H(+) exchanger ClC-7/Ostm1.
Ludwig, C.F., Ullrich, F., Leisle, L., Stauber, T. and Jentsch, T.J.
Journal of Biological Chemistry 288
(40): 28611-28619.
4 October 2013
Exome sequencing reveals new causal mutations in children with epileptic encephalopathies.
Veeramah, K.R., Johnstone, L., Karafet, T.M., Wolf, D., Sprissler, R., Salogiannis, J., Barth-Maron, A., Greenberg, M.E., Stuhlmann, T., Weinert, S., Jentsch, T.J., Pazzi, M., Restifo, L.L., Talwar, D., Erickson, R.P. and Hammer, M.F.
Epilepsia 54
(7): 1270-1281.
July 2013
From mice to man: chloride transport in leukoencephalopathy.
Jentsch, T.J.
Lancet Neurology 12
(7): 626-628.
July 2013
Potentiation of the transient receptor potential vanilloid 1 channel contributes to pruritogenesis in a rat model of liver disease.
Belghiti, M., Estevez-Herrera, J., Gimenez-Garzo, C., Gonzalez-Usano, A., Montoliu, C., Ferrer-Montiel, A., Felipo, V. and Planells-Cases, R.
Journal of Biological Chemistry 288
(14): 9675-9685.
5 April 2013
Vestibular role of KCNQ4 and KCNQ5 K(+) channels revealed by mouse models.
Spitzmaul, G., Tolosa, L., Winkelman, B.H.J., Heidenreich, M., Frens, M.A., Chabbert, C., de Zeeuw, C.I. and Jentsch, T.J.
Journal of Biological Chemistry 288
(13): 9334-9344.
29 March 2013
The new KCNQ2 activator 4-Chlor-N-(6-chlor-pyridin-3-yl)-benzamid displays anticonvulsant potential.
Boehlen, A., Schwake, M., Dost, R., Kunert, A., Fidzinski, P., Heinemann, U. and Gebhardt, C.
British Journal of Pharmacology 168
(5): 1182-1200.
March 2013
Chloride in vesicular trafficking and function.
Stauber, T. and Jentsch, T.J.
Annual Review of Physiology 75
: 453-477.
10 February 2013
2012
A mouse model for distal renal tubular acidosis reveals a previously unrecognized role of the V-ATPase a4 subunit in the proximal tubule.
Hennings, J.C., Picard, N., Huebner, A.K., Stauber, T., Maier, H., Brown, D., Jentsch, T.J., Vargas-Poussou, R., Eladari, D. and Huebner, C.A.
EMBO Molecular Medicine 4
(10): 1057-1071.
October 2012
Cell biology and physiology of CLC chloride channels and transporters.
Stauber, T., Weinert, S. and Jentsch, T.J.
Comprehensive Physiology 2
(3): 1701-1744.
1 July 2012
Elucidating membrane structure and protein behavior using giant plasma membrane vesicles.
Sezgin, E., Kaiser, H.J., Baumgart, T., Schwille, P., Simons, K. and Levental, I.
Nature Protocols 7
(6): 1042-1051.
June 2012
GlialCAM, a protein defective in a leukodystrophy, serves as a ClC-2 Cl(-) channel auxiliary subunit.
Jeworutzki, E., Lopez-Hernandez, T., Capdevila-Nortes, X., Sirisi, S., Bengtsson, L., Montolio, M., Zifarelli, G., Arnedo, T., Mueller, C.S., Schulte, U., Nunes, V., Martinez, A., Jentsch, T.J., Gasull, X., Pusch, M. and Estevez, R.
Neuron 73
(5): 951-961.
8 March 2012
Raising cytosolic Cl(-) in cerebellar granule cells affects their excitability and vestibulo-ocular learning.
Seja, P., Schonewille, M., Spitzmaul, G., Badura, A., Klein, I., Rudhard, Y., Wisden, W., Huebner, C.A., De Zeeuw, C.I. and Jentsch, T.J.
EMBO Journal 31
(5): 1217-1230.
17 January 2012
KCNQ4 K(+) channels tune mechanoreceptors for normal touch sensation in mouse and man.
Heidenreich, M., Lechner, S.G., Vardanyan, V., Wetzel, C., Cremers, C.W., De Leenheer, E.M., Aranguez, G., Moreno-Pelayo, M.A., Jentsch, T.J. and Lewin, G.R.
Nature Neuroscience 15
(1): 138-145.
2012
2011
Enhanced synaptic activity and epileptiform events in the embryonic KCC2 deficient hippocampus.
Khalilov, I., Chazal, G., Chudotvorova, I., Pellegrino, C., Corby, S., Ferrand, N., Gubkina, O., Nardou, R., Tyzio, R., Yamamoto, S., Jentsch, T.J., Huebner, C.A., Gaiarsa, J.L., Ben-Ari, Y. and Medina, I.
Frontiers in Cellular Neuroscience 5
: 23.
1 November 2011
Generation and analyses of R8L barttin knockin mouse.
Nomura, N., Tajima, M., Sugawara, N., Morimoto, T., Kondo, Y., Ohno, M., Uchida, K., Mutig, K., Bachmann, S., Soleimani, M., Ohta, E., Ohta, A., Sohara, E., Okado, T., Rai, T., Jentsch, T.J., Sasaki, S. and Uchida, S.
American Journal of Physiology Renal Physiology 301
(2): F297-F307.
August 2011
ClC-7 is a slowly voltage-gated 2Cl(-)/1H(+)-exchanger and requires Ostm1 for transport activity.
Leisle, L., Ludwig, C.F., Wagner, F.A., Jentsch, T.J. and Stauber, T.
EMBO Journal 30
(11): 2140-2152.
1 June 2011
Ca(2+)-activated Cl(-) currents are dispensable for olfaction.
Billig, G.M., Pal, B., Fidzinski, P. and Jentsch, T.J.
Nature Neuroscience 14
(6): 763-769.
June 2011
Recurrent stroke due to a novel voltage sensor mutation in Ca(v)2.1 responds to verapamil.
Knierim, E., Leisle, L., Wagner, C., Weschke, B., Lucke, B., Bohner, G., Dreier, J.P. and Schuelke, M.
Stroke 42
(2): e14-e17.
February 2011
2010
Distinct neuropathologic phenotypes after disrupting the chloride transport proteins ClC-6 or ClC-7/Ostm1.
Pressey, S.N., O'Donnell, K.J., Stauber, T., Fuhrmann, J.C., Tyynelae, J., Jentsch, T.J. and Cooper, J.D.
Journal of Neuropathology and Experimental Neurology 69
(12): 1228-1246.
December 2010
Sorting motifs of the endosomal/lysosomal CLC chloride transporters.
Stauber, T. and Jentsch, T.J.
Journal of Biological Chemistry 285
(45): 34537-34548.
5 November 2010
ClC-3-A granular anion transporter involved in insulin secretion?
Jentsch, T.J., Maritzen, T., Keating, D.J., Zdebik, A.A. and Thevenod, F.
Cell Metabolism 12
(4): 307-308.
6 October 2010
The G215R mutation in the Cl-/H+-antiporter ClC-7 found in ADO II osteopetrosis does not abolish function but causes a severe trafficking defect.
Schulze, K., Werner, J., Stauber, T., Henriksen, K. and Fendler, K.
PLoS ONE 5
(9): e12585.
7 September 2010
The late endosomal CLC-6 mediates proton/chloride countertransport in heterologous plasma membrane expression.
Neagoe, I., Stauber, T., Fidzinski, P., Bergsdorf, E.Y. and Jentsch, T.J.
Journal of Biological Chemistry 285
(28): 21689-21697.
9 July 2010
A cation counterflux supports lysosomal acidification.
Steinberg, B.E., Huynh, K.K., Brodovitch, A., Jabs, S., Stauber, T., Jentsch, T.J. and Grinstein, S.
Journal of Cell Biology 189
(7): 1171-1186.
28 June 2010
Endosomal chloride-proton exchange rather than chloride conductance is crucial for renal endocytosis.
Novarino, G., Weinert, S., Rickheit, G. and Jentsch, T.J.
Science 328
(5984): 1398-1401.
11 June 2010
Lysosomal pathology and osteopetrosis upon loss of H+-driven lysosomal Cl- accumulation.
Weinert, S., Jabs, S., Supanchart, C., Schweizer, M., Gimber, N., Richter, M., Rademann, J., Stauber, T., Kornak, U. and Jentsch, T.J.
Science 328
(5984): 1401-1403.
11 June 2010
Role of CLC-5 in renal endocytosis is unique among CLC exchangers and does not require py-motif-dependent ubiquitylation.
Rickheit, G., Wartosch, L., Schaffer, S., Stobrawa, S., Novarino, G., Weinert, S. and Jentsch, T.J.
Journal of Biological Chemistry 285
(23): 17595-17603.
4 June 2010
The KCNQ5 potassium channel mediates a component of the afterhyperpolarization current in mouse hippocampus.
Tzingounis, A.V., Heidenreich, M., Kharkovets, T., Spitzmaul, G., Jensen, H.S., Nicoll, R.A. and Jentsch, T.J.
Proceedings of the National Academy of Sciences of the United States of America 107
(22): 10232-10237.
1 June 2010
Analysis of CLCN2 as candidate gene for megalencephalic leukoencephalopathy with subcortical cysts.
Scheper, G.C., van Berkel, C.G., Leisle, L., de Groot, K.E., Errami, A., Jentsch, T.J. and Van der Knaap, M.S.
Genetic Testing and Molecular Biomarkers 14
(2): 255-257.
April 2010
Disruption of the K+ channel beta-subunit KCNE3 reveals an important role in intestinal and tracheal Cl- transport.
Preston, P., Wartosch, L., Guenzel, D., Fromm, M., Kongsuphol, P., Ousingsawat, J., Kunzelmann, K., Barhanin, J., Warth, R. and Jentsch, T.J.
Journal of Biological Chemistry 285
(10): 7165-7175.
5 March 2010
A role for chloride transport in lysosomal protein degradation.
Wartosch, L. and Stauber, T.
Autophagy 6
(1): 158-159.
January 2010
No evidence for a role of CLCN2 variants in idiopathic generalized epilepsy.
Niemeyer, M.I., Cid, L.P., Sepulveda, F.V., Blanz, J., Auberson, M. and Jentsch, T.J.
Nature Genetics 42
(1): 3.
January 2010
The CLC family of chloride channels and transporters.
Stauber, T., Novarino, G. and Jentsch, T.J.
In:
Physiology and Pathology of Chloride Transporters and Channels in the Nervous System : From Molecules to Diseases.
Elsevier, 209-231.
ISBN 978-0-12-374373-2
2010
2009
Lysosomal degradation of endocytosed proteins depends on the chloride transport protein ClC-7.
Wartosch, L., Fuhrmann, J.C., Schweizer, M., Stauber, T. and Jentsch, T.J.
FASEB Journal 23
(12): 4056-4068.
December 2009
Potassium ion movement in the inner ear: insights from genetic disease and mouse models.
Zdebik, A.A., Wangemann, P. and Jentsch, T.J.
Physiology 24
(5): 307-316.
October 2009
Physiological roles of CLC Cl(-)/H (+) exchangers in renal proximal tubules.
Plans, V., Rickheit, G. and Jentsch, T.J.
Pfluegers Archiv European Journal of Physiology 458
(1): 23-37.
May 2009
Residues important for nitrate/proton coupling in plant and mammalian CLC transporters.
Bergsdorf, E.Y., Zdebik, A.A. and Jentsch, T.J.
Journal of Biological Chemistry 284
(17): 11184-11193.
24 April 2009
NKCC1-dependent GABAergic excitation drives synaptic network maturation during early hippocampal development.
Pfeffer, C.K., Stein, V., Keating, D.J., Maier, H., Rinke, I., Rudhard, Y., Hentschke, M., Rune, G.M., Jentsch, T.J. and Huebner, C.A.
Journal of Neuroscience 29
(11): 3419-3430.
18 March 2009
Chloride channelopathies.
Planells-Cases, R. and Jentsch, T.J.
Biochimica et Biophysica Acta - Molecular Basis of Disease 1792
(3): 173-189.
March 2009
Muscarinic acetylcholine receptors and voltage-gated calcium channels contribute to bidirectional synaptic plasticity at CA1-subiculum synapses.
Shor, O.L., Fidzinski, P. and Behr, J.
Neuroscience Letters 449
(3): 220-223.
16 January 2009
2008
ATP release through connexin hemichannels and gap junction transfer of second messengers propagate Ca2+ signals across the inner ear.
Anselmi, F., Hernandez, V.H., Crispino, G., Seydel, A., Ortolano, S., Roper, S.D., Kessaris, N., Richardson, W., Rickheit, G., Filippov, M.A., Monyer, H. and Mammano, F.
Proceedings of the National Academy of Sciences of the United States of America 105
(48): 18770-18775.
2 December 2008
Endocochlear potential depends on Cl(-) channels: mechanism underlying deafness in Bartter syndrome IV.
Rickheit, G., Maier, H., Strenzke, N., Andreescu, C.E., De Zeeuw, C.I., Muenscher, A., Zdebik, A.A. and Jentsch, T.J.
EMBO Journal 27
(21): 2907-2917.
5 November 2008
Role of the vesicular chloride transporter ClC-3 in neuroendocrine tissue.
Maritzen, T., Keating, D.J., Neagoe, I., Zdebik, A.A. and Jentsch, T.J.
Journal of Neuroscience 28
(42): 10587-10598.
15 October 2008
Kv7 channels: interaction with dopaminergic and serotonergic neurotransmission in the CNS.
Hansen, H.H., Waroux, O., Seutin, V., Jentsch, T.J., Aznar, S. and Mikkelsen, J.D.
Journal of Physiology 586
(7): 1823-1832.
1 April 2008
Determinants of anion-proton coupling in mammalian endosomal CLC proteins.
Zdebik, A.A., Zifarelli, G., Bergsdorf, E.Y., Soliani, P., Scheel, O., Jentsch, T.J. and Pusch, M.
Journal of Biological Chemistry 283
(7): 4219-4227.
15 February 2008
CLC chloride channels and transporters: from genes to protein structure, pathology and physiology.
Jentsch, T.J.
Critical Reviews in Biochemistry and Molecular Biology 43
(1): 3-36.
January 2008
Channelopathies of transepithelial transport and vesicular function.
Huebner, C.A. and Jentsch, T.J.
Advances in Genetics 63
: 113-152.
2008
2007
Detection and differentiation of sensorineural hearing loss in mice using auditory steady-state responses and transient auditory brainstem responses.
Pauli-Magnus, D., Hoch, G., Strenzke, N., Anderson, S., Jentsch, T.J. and Moser, T.
Neuroscience 149
(3): 673-684.
9 November 2007
Leukoencephalopathy upon disruption of the chloride channel ClC-2.
Blanz, J., Schweizer, M., Auberson, M., Maier, H., Muenscher, A., Huebner, C.A. and Jentsch, T.J.
Journal of Neuroscience 27
(24): 6581-9.
13 June 2007
Disruption of erythroid K-Cl cotransporters alters erythrocyte volume and partially rescues erythrocyte dehydration in SAD mice.
Rust, M.B., Alper, S.L., Rudhard, Y., Shmukler, B.E., Vicente, R., Brugnara, C., Trudel, M., Jentsch, T.J. and Huebner, C.A.
Journal of Clinical Investigation 117
(6): 1708-1717.
1 June 2007
Chloride and the endosomal/lysosomal pathway: emerging roles of CLC chloride transporters.
Jentsch, T.J.
Journal of Physiology 578
(Pt 3): 633-640.
February 2007
2006
Lysosomal storage disease upon disruption of the neuronal chloride transport protein ClC-6.
Poet, M., Kornak, U., Schweizer, M., Zdebik, A.A., Scheel, O., Hoelter, S., Wurst, W., Schmitt, A., Fuhrmann, J.C., Planells-Cases, R., Mole, S.E., Huebner, C.A. and Jentsch, T.J.
Proceedings of the National Academy of Sciences of the United States of America 103
(37): 13854-13859.
12 September 2006
Kidney-specific upregulation of vitamin D3 target genes in ClC-5 KO mice.
Maritzen, T., Rickheit, G., Schmitt, A. and Jentsch, T.J.
Kidney International 70
(1): 79-87.
1 July 2006
Structural determinants of M-type KCNQ (Kv7) K+ channel assembly.
Schwake, M., Athanasiadu, D., Beimgraben, C., Blanz, J., Beck, C., Jentsch, T.J., Saftig, P. and Friedrich, T.
Journal of Neuroscience 26
(14): 3757-3766.
5 April 2006
ClC-7 requires Ostm1 as a beta-subunit to support bone resorption and lysosomal function.
Lange, P.F., Wartosch, L., Jentsch, T.J. and Fuhrmann, J.C.
Nature 440
(7081): 220-223.
9 March 2006
Neurogenic mechanisms contribute to hypertension in mice with disruption of the K-Cl cotransporter KCC3.
Rust, M.B., Faulhaber, J., Budack, M.K., Pfeffer, P., Maritzen, T., Didie, M., Beck, F.X., Boettger, T., Schubert, R., Ehmke, H., Jentsch, T.J. and Huebner, C.A.
Circulation Research 98
(4): 549-556.
3 March 2006
Mice with altered KCNQ4 K+ channels implicate sensory outer hair cells in human progressive deafness.
Kharkovets, T., Dedek, K., Maier, H., Schweizer, M., Khimich, D., Nouvian, R., Vardanyan, V., Leuwer, R., Moser, T. and Jentsch, T.J.
EMBO Journal 25
(3): 642-652.
8 February 2006
Mice with a targeted disruption of the Cl-/HCO3- exchanger AE3 display a reduced seizure threshold.
Hentschke, M., Wiemann, M., Hentschke, S., Kurth, I., Hermans-Borgmeyer, I., Seidenbecher, T., Jentsch, T.J., Gal, A. and Huebner, C.A.
Molecular and Cellular Biology 26
(1): 182-191.
January 2006
2005
Chloride channel diseases resulting from impaired transepithelial transport or vesicular function.
Jentsch, T.J., Maritzen, T. and Zdebik, A.A.
Journal of Clinical Investigation 115
(8): 2039-2046.
August 2005
Voltage-dependent electrogenic chloride/proton exchange by endosomal CLC proteins.
Scheel, O., Zdebik, A.A., Lourdel, S. and Jentsch, T.J.
Nature 436
(7049): 424-427.
21 July 2005
CLC chloride channels and transporters.
Jentsch, T.J., Neagoe, I. and Scheel, O.
Current Opinion in Neurobiology 15
(3): 319-325.
June 2005
Chloride transport in the kidney: lessons from human disease and knockout mice.
Jentsch, T.J.
Journal of the American Society of Nephrology 16
(6): 1549-1561.
June 2005
Molecular determinants of KCNQ (Kv7) K+ channel sensitivity to the anticonvulsant retigabine.
Schenzer, A., Friedrich, T., Pusch, M., Saftig, P., Jentsch, T.J., Groetzinger, J. and Schwake, M.
Journal of Neuroscience 25
(20): 5051-5060.
18 May 2005
Loss of the chloride channel ClC-7 leads to lysosomal storage disease and neurodegeneration.
Kasper, D., Planells-Cases, R., Fuhrmann, J.C., Scheel, O., Zeitz, O., Ruether, K., Schmitt, A., Poet, M., Steinfeld, R., Schweizer, M., Kornak, U. and Jentsch, T.J.
EMBO Journal 24
(5): 1079-1091.
9 March 2005
Physiological functions of CLC Cl- channels gleaned from human genetic disease and mouse models.
Jentsch, T.J., Poet, M., Fuhrmann, J.C. and Zdebik, A.A.
Annual Review of Physiology 67
: 779-807.
March 2005
Unique structure and function of chloride transporting CLC proteins.
Pusch, M. and Jentsch, T.J.
IEEE Transactions on Nanobioscience 4
(1): 49-57.
March 2005
2004
Ion channels: function unravelled by dysfunction.
Jentsch, T.J., Huebner, C.A. and Fuhrmann, J.C.
Nature Cell Biology 6
(11): 1039-1047.
November 2004
Plasmodium induces swelling-activated ClC-2 anion channels in the host erythrocyte.
Huber, S.M., Duranton, C., Henke, G., Van De Sand, C., Heussler, V., Shumilina, E., Sandu, C.D., Tanneur, V., Brand, V., Kasinathan, R.S., Lang, K.S., Kremsner, P.G., Huebner, C.A., Rust, M.B., Dedek, K., Jentsch, T.J. and Lang, F.
Journal of Biological Chemistry 279
(40): 41444-41452.
1 October 2004
Functional and structural conservation of CBS domains from CLC chloride channels.
Estevez, R., Pusch, M., Ferrer-Costa, C., Orozco, M. and Jentsch, T.J.
Journal of Physiology 557
(Pt 2): 363-378.
1 June 2004
Additional disruption of the ClC-2 Cl(-) channel does not exacerbate the cystic fibrosis phenotype of cystic fibrosis transmembrane conductance regulator mouse models.
Zdebik, A.A., Cuffe, J.E., Bertog, M., Korbmacher, C. and Jentsch, T.J.
Journal of Biological Chemistry 279
(21): 22276-22283.
21 May 2004
Expression of the KCl cotransporter KCC2 parallels neuronal maturation and the emergence of low intracellular chloride.
Stein, V., Hermans-Borgmeyer, I., Jentsch, T.J. and Huebner, C.A.
Journal of Comparative Neurology 468
(1): 57-64.
1 January 2004
2003
Loss of K-Cl co-transporter KCC3 causes deafness, neurodegeneration and reduced seizure threshold.
Boettger, T., Rust, M.B., Maier, H., Seidenbecher, T., Schweizer, M., Keating, D.J., Faulhaber, J., Ehmke, H., Pfeffer, C., Scheel, O., Lemcke, B., Horst, J., Leuwer, R., Pape, H.C., Voelkl, H., Huebner, C.A. and Jentsch, T.J.
EMBO Journal 22
(20): 5422-5434.
15 October 2003
Conservation of chloride channel structure revealed by an inhibitor binding site in ClC-1.
Estevez, R., Schroeder, B.C., Accardi, A., Jentsch, T.J. and Pusch, M.
Neuron 38
(1): 47-59.
10 April 2003
A carboxy-terminal domain determines the subunit specificity of KCNQ K+ channel assembly.
Schwake, M., Jentsch, T.J. and Friedrich, T.
EMBO Reports 4
(1): 76-81.
January 2003
The ClC-5 chloride channel knock-out mouse - an animal model for Dent's disease.
Guenther, W., Piwon, N. and Jentsch, T.J.
Pfluegers Archiv European Journal of Physiology 445
(4): 456-462.
January 2003
2002
Ion channel diseases.
Huebner, C.A. and Jentsch, T.J.
Human Molecular Genetics 11
(20): 2435-2445.
1 October 2002
CLC chloride channels: correlating structure with function.
Estevez, R. and Jentsch, T.J.
Current Opinion in Structural Biology 12
(4): 531-539.
August 2002
Deafness and renal tubular acidosis in mice lacking the K-Cl co-transporter Kcc4.
Boettger, T., Huebner, C.A., Maier, H., Rust, M.B., Beck, F.X. and Jentsch, T.J.
Nature 416
(6883): 874-878.
25 April 2002
Molecular structure and physiological function of chloride channels.
Jentsch, T.J., Stein, V., Weinreich, F. and Zdebik, A.A.
Physiological Reviews 82
(2): 503-568.
April 2002
Chloride channels are different.
Jentsch, T.J.
Nature 415
(6869): 276-277.
17 January 2002
2001
Barttin is a Cl- channel beta-subunit crucial for renal Cl- reabsorption and inner ear K+ secretion.
Estevez, R., Boettger, T., Stein, V., Birkenhaeger, R., Otto, E., Hildebrandt, F. and Jentsch, T.J.
Nature 414
(6863): 558-561.
29 November 2001
Planned law could put German research at risk.
Jentsch, T.
Nature 413
(6858): 772.
25 October 2001
Myokymia and neonatal epilepsy caused by a mutation in the voltage sensor of the KCNQ2 K+ channel.
Dedek, K., Kunath, B., Kananura, C., Reuner, U., Jentsch, T.J. and Steinlein, O.K.
Proceedings of the National Academy of Sciences of the United States of America 98
(21): 12272-12277.
9 October 2001
Mutations in CAV3 cause mechanical hyperirritability of skeletal muscle in rippling muscle disease.
Betz, R.C., Schoser, B.G.H., Kasper, D., Ricker, K., Ramirez, A., Stein, V., Torbergsen, T., Lee, Y.A., Nothen, M.M., Wienker, T.F., Malin, J.P., Propping, P., Reis, A., Mortier, W., Jentsch, T.J., Vorgerd, M. and Kubisch, C.
Nature Genetics 28
(3): 218-219.
July 2001
An internalization signal in ClC-5, an endosomal Cl-channel mutated in dent's disease.
Schwake, M., Friedrich, T. and Jentsch, T.J.
Journal of Biological Chemistry 276
(15): 12049-12054.
13 April 2001
Male germ cells and photoreceptors, both dependent on close cell-cell interactions, degenerate upon ClC-2 Cl(-) channel disruption.
Boesl, M.R., Stein, V., Huebner, C.A., Zdebik, A.A., Jordt, S.E., Mukhopadhyay, A.K., Davidoff, M.S., Holstein, A.F. and Jentsch, T.J.
EMBO Journal 20
(6): 1289-1299.
15 March 2001
Disruption of KCC2 reveals an essential role of K-Cl cotransport already in early synaptic inhibition.
Huebner, C.A., Stein, V., Hermans-Borgmeyer, I., Meyer, T., Ballanyi, K. and Jentsch, T.J.
Neuron 30
(2): 515-524.
March 2001
Tissue distribution and subcellular localization of the ClC-5 chloride channel in rat intestinal cells.
Vandewalle, A., Cluzeaud, F., Peng, K.C., Bens, M., Luechow, A., Guenther, W. and Jentsch, T.J.
American Journal of Physiology Cell Physiology 280
(2): C373-C381.
February 2001
Loss of the ClC-7 chloride channel leads to osteopetrosis in mice and man.
Kornak, U., Kasper, D., Boesl, M.R., Kaiser, E., Schweizer, M., Schulz, A., Friedrich, W., Delling, G. and Jentsch, T.J.
Cell 104
(2): 205-215.
26 January 2001
Pores formed by single subunits in mixed dimers of different CLC chloride channels.
Weinreich, F. and Jentsch, T.J.
Journal of Biological Chemistry 276
(4): 2347-2353.
26 January 2001
Disruption of ClC-3, a chloride channel expressed on synaptic vesicles, leads to a loss of the hippocampus.
Stobrawa, S.M., Breiderhoff, T., Takamori, S., Engel, D., Schweizer, M., Zdebik, A.A., Boesl, M.R., Ruether, K., Jahn, H., Draguhn, A., Jahn, R. and Jentsch, T.J.
Neuron 29
(1): 185-196.
January 2001
2000
ClC-5 Cl- -channel disruption impairs endocytosis in a mouse model for Dent's disease.
Piwon, N., Guenther, W., Schwake, M., Boesl, M.R. and Jentsch, T.J.
Nature 408
(6810): 369-373.
16 November 2000
Neuronal KCNQ potassium channels: physiology and role in disease.
Jentsch, T.J.
Nature Reviews Neuroscience 1
(1): 21-30.
October 2000
Mutations in the a3 subunit of the vacuolar H(+)-ATPase cause infantile malignant osteopetrosis.
Kornak, U., Schulz, A., Friedrich, W., Uhlhaas, S., Kremens, B., Voit, T., Hasan, C., Bode, U., Jentsch, T.J. and Kubisch, C.
Human Molecular Genetics 9
(13): 2059-2063.
12 August 2000
Functional and structural analysis of ClC-K chloride channels involved in renal disease.
Waldegger, S. and Jentsch, T.J.
Journal of Biological Chemistry 275
(32): 24527-24533.
11 August 2000
KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents.
Schroeder, B.C., Hechenberger, M., Weinreich, F., Kubisch, C. and Jentsch, T.J.
Journal of Biological Chemistry 275
(31): 24089-24095.
4 August 2000
Characterization of renal chloride channel (CLCN5) mutations in Dent's disease.
Yamamoto, K., Cox, J.P., Friedrich, T., Christie, P.T., Bald, M., Houtman, P.N., Lapsley, M.J., Patzer, L., Tsimaratos, M., Van'T Hoff, W.G., Yamaoka, K., Jentsch, T.J. and Thakker, R.V.
Journal of the American Society of Nephrology 11
(8): 1460-1468.
August 2000
Pathophysiology of KCNQ channels: neonatal epilepsy and progressive deafness.
Jentsch, T.J., Schroeder, B.C., Kubisch, C., Friedrich, T. and Stein, V.
Epilepsia 41
(8): 1068-1069.
August 2000
A function for dysfunction - Ion channels and disease.
Jentsch, T.J.
Nature 406
(6793): 236-237.
20 July 2000
From tonus to tonicity: physiology of CLC chloride channels.
Waldegger, S. and Jentsch, T.J.
Journal of the American Society of Nephrology 11
(7): 1331-1339.
July 2000
Neurological diseases caused by ion-channel mutations.
Weinreich, F. and Jentsch, T.J.
Current Opinion in Neurobiology 10
(3): 409-415.
June 2000
Surface expression and single channel properties of KCNQ2/KCNQ3, M-type K+ channels involved in epilepsy.
Schwake, M., Pusch, M., Kharkovets, T. and Jentsch, T.J.
Journal of Biological Chemistry 275
(18): 13343-13348.
5 May 2000
KCNQ4, a K+ channel mutated in a form of dominant deafness, is expressed in the inner ear and the central auditory pathway.
Kharkovets, T., Hardelin, J.P., Safieddine, S., Schweizer, M., El-Amraoui, A., Petit, C. and Jentsch, T.J.
Proceedings of the National Academy of Sciences of the United States of America 97
(8): 4333-4338.
11 April 2000
Inhibition of KCNQ1-4 potassium channels expressed in mammalian cells via M1 muscarinic acetylcholine receptors.
Selyanko, A.A., Hadley, J.K., Wood, I.C., Abogadie, F.C., Jentsch, T.J. and Brown, D.A.
Journal of Physiology 522
(Pt 3): 349-355.
1 February 2000
A constitutively open potassium channel formed by KCNQ1 and KCNE3.
Schroeder, B.C., Waldegger, S., Fehr, S., Bleich, M., Warth, R., Greger, R. and Jentsch, T.J.
Nature 403
(6766): 196-199.
13 January 2000
1999
CLC chloride channels in Caenorhabditis elegans.
Schriever, A.M., Friedrich, T., Pusch, M. and Jentsch, T.J.
Journal of Biological Chemistry 274
(48): 34238-34244.
26 November 1999
The CLC chloride channel family.
Jentsch, T.J., Friedrich, T., Schriever, A. and Yamada, H.
Pfluegers Archiv European Journal of Physiology 437
(6): 783-795.
May 1999
Chloride dependence of hyperpolarization-activated chloride channel gates.
Pusch, M., Jordt, S.E., Stein, V. and Jentsch, T.J.
Journal of Physiology 515
(Pt 2): 341-353.
1 March 1999
KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness.
Kubisch, C., Schroeder, B.C., Friedrich, T., Luetjohann, B., El-Amraoui, A., Marlin, S., Petit, C. and Jentsch, T.J.
Cell 96
(3): 437-446.
5 February 1999
Mutational analysis demonstrates that ClC-4 and ClC-5 directly mediate plasma membrane currents.
Friedrich, T., Breiderhoff, T. and Jentsch, T.J.
Journal of Biological Chemistry 274
(2): 896-902.
8 January 1999
1998
Moderate loss of function of cyclic-AMP-modulated KCNQ2/KCNQ3 K+ channels causes epilepsy.
Schroeder, B.C., Kubisch, C., Stein, V. and Jentsch, T.J.
Nature 396
(6712): 687-690.
17 December 1998
Functional characterization of renal chloride channel, CLCN5, mutations associated with Dent'sJapan disease.
Igarashi, T., Guenther, W., Sekine, T., Inatomi, J., Shiraga, H., Takahashi, S., Suzuki, J., Tsuru, N., Yanagihara, T., Shimazu, M., Jentsch, T.J. and Thakker, R.V.
Kidney International 54
(6): 1850-1856.
December 1998
KCNQ2, the first gene found to be mutated in human generalized idiopathic epilepsy.
Steinlein, O.K. and Jentsch, T.J.
Pathologie Biologie 46
(9): 683-684.
November 1998
ClC-1 chloride channel mutations in myotonia congenita: variable penetrance of mutations shifting the voltage dependence.
Kubisch, C., Schmidt-Rose, T., Fontaine, B., Bretag, A.H. and Jentsch, T.J.
Human Molecular Genetics 7
(11): 1753-1760.
October 1998
Molecular physiology of renal chloride channels.
Steinmeyer, K. and Jentsch, T.J.
Current Opinion in Nephrology and Hypertension 7
(5): 497-502.
September 1998
ClC-5, the chloride channel mutated in Dent's disease, colocalizes with the proton pump in endocytotically active kidney cells.
Guenther, W., Luechow, A., Cluzeaud, F., Vandewalle, A. and Jentsch, T.J.
Proceedings of the National Academy of Sciences of the United States of America 95
(14): 8075-8080.
7 July 1998
Golgi localization and functionally important domains in the NH2 and COOH terminus of the yeast CLC putative chloride channel Gef1p.
Schwappach, B., Stobrawa, S., Hechenberger, M., Steinmeyer, K. and Jentsch, T.J.
Journal of Biological Chemistry 273
(24): 15110-15108.
12 June 1998
Permeation and block of the skeletal muscle chloride channel, ClC-1, by foreign anions.
Rychkov, G.Y., Pusch, M., Roberts, M.L., Jentsch, T.J. and Bretag, A.H.
Journal of General Physiology 111
(5): 653-665.
May 1998
Determinants of slow gating in ClC-0, the voltage-gated chloride channel of Torpedo marmorata.
Fong, P., Rehfeldt, A. and Jentsch, T.J.
American Journal of Physiology 274
(4 Pt 1): C966-C973.
April 1998
Novel muscle chloride channel (CLCN1) mutations in myotonia congenita with various modes of inheritance including incomplete dominance and penetrance.
Plassart-Schiess, E., Gervais, A., Eymard, B., Lagueny, A., Pouget, J., Warter, J.M., Fardeau, M., Jentsch, T.J. and Fontaine, B.
Neurology 50
(4): 1176-1179.
April 1998
Characterization of the hyperpolarization-activated chloride current in dissociated rat sympathetic neurons.
Clark, S., Jordt, S.E., Jentsch, T.J. and Mathie, A.
Journal of Physiology 506
(Pt 3): 665-678.
1 February 1998
A potassium channel mutation in neonatal human epilepsy.
Biervert, C., Schroeder, B.C., Kubisch, C., Berkovic, S.F., Propping, P., Jentsch, T.J. and Steinlein, O.K.
Science 279
(5349): 403-406.
16 January 1998
Molecular diagnosis of McArdle disease: revised genomic structure of the myophosphorylase gene and identification of a novel mutation.
Kubisch, C., Wicklein, E.M. and Jentsch, T.J.
Human Mutation 12
(1): 27-32.
1998
1997
Pathophysiological mechanisms of dominant and recessive KVLQT1 K+ channel mutations found in inherited cardiac arrhythmias.
Wollnik, B., Schroeder, B.C., Kubisch, C., Esperer, H.D., Wieacker, P. and Jentsch, T.J.
Human Molecular Genetics 6
(11): 1943-1949.
October 1997
Reconstitution of functional voltage-gated chloride channels from complementary fragments of CLC-1.
Schmidt-Rose, T. and Jentsch, T.J.
Journal of Biological Chemistry 272
(33): 20515-20521.
15 August 1997
Characterisation of renal chloride channel, CLCN5, mutations in hypercalciuric nephrolithiasis (kidney stones) disorders.
Lloyd, S.E., Gunther, W., Pearce, S.H., Thomson, A., Bianchi, M.L., Bosio, M., Craig, I.W., Fisher, S.E., Scheinman, S.J., Wrong, O., Jentsch, T.J. and Thakker, R.V.
Human Molecular Genetics 6
(8): 1233-1239.
August 1997
Independent gating of single pores in CLC-0 chloride channels.
Ludewig, U., Pusch, M. and Jentsch, T.J.
Biophysical Journal 73
(2): 789-797.
August 1997
Inward rectification in ClC-0 chloride channels caused by mutations in several protein regions.
Ludewig, U., Jentsch, T.J. and Pusch, M.
Journal of General Physiology 110
(2): 165-171.
August 1997
Transmembrane topology of a CLC chloride channel.
Schmidt-Rose, T. and Jentsch, T.J.
Proceedings of the National Academy of Sciences of the United States of America 94
(14): 7633-7638.
8 July 1997
Localization and induction by dehydration of ClC-K chloride channels in the rat kidney.
Vandewalle, A., Cluzeaud, F., Bens, M., Kieferle, S., Steinmeyer, K. and Jentsch, T.J.
American Journal of Physiology 272
(5 Pt 2): F678-F688.
May 1997
Molecular dissection of gating in the ClC-2 chloride channel.
Jordt, S.E. and Jentsch, T.J.
EMBO Journal 16
(7): 1582-1592.
1 April 1997
Idiopathic low molecular weight proteinuria associated with hypercalciuric nephrocalcinosis in Japanese children is due to mutations of the renal chloride channel (CLCN5).
Lloyd, S.E., Pearce, S.H., Guenther, W., Kawaguchi, H., Igarashi, T., Jentsch, T.J. and Thakker, R.V.
Journal of Clinical Investigation 99
(5): 967-974.
1 March 1997
Analysis of a protein region involved in permeation and gating of the voltage-gated Torpedo chloride channel ClC-0.
Ludewig, U., Jentsch, T.J. and Pusch, M.
Journal of Physiology 498
(Pt 3): 691-702.
1 February 1997
Chloride channels: an emerging molecular picture.
Jentsch, T.J. and Guenther, W.
BioEssays 19
(2): 117-126.
February 1997
Temperature dependence of fast and slow gating relaxations of ClC-0 chloride channels.
Pusch, M., Ludewig, U. and Jentsch, T.J.
Journal of General Physiology 109
(1): 105-116.
January 1997
1996
A family of putative chloride channels from Arabidopsis and functional complementation of a yeast strain with a CLC gene disruption.
Hechenberger, M., Schwappach, B., Fischer, W.N., Frommer, W.B., Jentsch, T.J. and Steinmeyer, K.
Journal of Biological Chemistry 271
(52): 33632-33638.
27 December 1996
Concentration and pH dependence of skeletal muscle chloride channel ClC-1.
Rychkov, G.Y., Pusch, M., Astill, D.S., Roberts, M.L., Jentsch, T.J. and Bretag, A.H.
Journal of Physiology 497
(Pt 2): 423-435.
1 December 1996
Heteromultimeric CLC chloride channels with novel properties.
Lorenz, C., Pusch, M. and Jentsch, T.J.
Proceedings of the National Academy of Sciences of the United States of America 93
(23): 13362-13366.
12 November 1996
Two physically distinct pores in the dimeric ClC-0 chloride channel.
Ludewig, U., Pusch, M. and Jentsch, T.J.
Nature 383
(6598): 340-343.
26 September 1996
Alteration of GABAA receptor function following gene transfer of the CLC-2 chloride channel.
Staley, K., Smith, R., Schaack, J., Wilcox, C. and Jentsch, T.J.
Neuron 17
(3): 543-551.
September 1996
Chloride Channel Myotonias.
Steinmeyer, K. and Jentsch, T.J.
Neuroscientist 2
(4): 225-232.
July 1996
Chloride channels: a molecular perspective.
Jentsch, T.J.
Current Opinion in Neurobiology 6
(3): 303-310.
June 1996
A common molecular basis for three inherited kidney stone diseases.
Lloyd, S.E., Pearce, S.H., Fisher, S.E., Steinmeyer, K., Schwappach, B., Scheinman, S.J., Harding, B., Bolino, A., Devoto, M., Goodyer, P., Rigden, S.P., Wrong, O., Jentsch, T.J., Craig, I.W. and Thakker, R.V.
Nature 379
(6564): 445-449.
1 February 1996
1995
Cloning and functional expression of rat CLC-5, a chloride channel related to kidney disease.
Steinmeyer, K., Schwappach, B., Bens, M., Vandewalle, A. and Jentsch, T.J.
Journal of Biological Chemistry 270
(52): 31172-31177.
29 December 1995
ClC-6 and ClC-7 are two novel broadly expressed members of the CLC chloride channel family.
Brandt, S. and Jentsch, T.J.
FEBS Letters 377
(1): 15-20.
11 December 1995
Mutations in dominant human myotonia congenita drastically alter the voltage dependence of the CIC-1 chloride channel.
Pusch, M., Steinmeyer, K., Koch, M.C. and Jentsch, T.J.
Neuron 15
(6): 1455-1463.
December 1995
Spectrum of mutations in the major human skeletal muscle chloride channel gene (CLCN1) leading to myotonia.
Meyer-Kleine, C., Steinmeyer, K., Ricker, K., Jentsch, T.J. and Koch, M.C.
American Journal of Human Genetics 57
(6): 1325-1334.
December 1995
Chloride channel 2 gene (Clc2) maps to chromosome 16 of the mouse, extending a region of conserved synteny with human chromosome 3q.
Lengeling, A., Gronemeier, M., Ronsiek, M., Thiemann, A., Jentsch, T.J. and Jockusch, H.
Genetical Research 66
(2): 175-178.
October 1995
Molecular basis of epithelial Cl channels.
Fong, P. and Jentsch, T.J.
Journal of Membrane Biology 144
(3): 189-197.
April 1995
Gating of the voltage-dependent chloride channel CIC-0 by the permeant anion.
Pusch, M., Ludewig, U., Rehfeldt, A. and Jentsch, T.J.
Nature 373
(6514): 527-531.
9 February 1995
Properties of voltage-gated chloride channels of the ClC gene family.
Jentsch, T.J., Guenther, W., Pusch, M. and Schwappach, B.
Journal of Physiology 482
: 19S-25S.
January 1995
Myotonias due to CLC-1 chloride channel mutations.
Jentsch, T.J., Lorenz, C., Pusch, M. and Steinmeyer, K.
Society of General Physiologists Series 50
: 149-159.
1995
1994
Role of innervation, excitability, and myogenic factors in the expression of the muscular chloride channel ClC-1. A study on normal and myotonic muscle.
Klocke, R., Steinmeyer, K., Jentsch, T.J. and Jockusch, H.
Journal of Biological Chemistry 269
(44): 27635-27639.
4 November 1994
Molecular physiology of voltage-gated chloride channels.
Pusch, M. and Jentsch, T.J.
Physiological Reviews 74
(4): 813-827.
October 1994
Molecular physiology of anion channels.
Jentsch, T.J.
Current Opinion in Cell Biology 6
(4): 600-606.
August 1994
Two highly homologous members of the ClC chloride channel family in both rat and human kidney.
Kieferle, S., Fong, P., Bens, M., Vandewalle, A. and Jentsch, T.J.
Proceedings of the National Academy of Sciences of the United States of America 91
(15): 6943-6947.
19 July 1994
Genomic organization of the human muscle chloride channel CIC-1 and analysis of novel mutations leading to Becker-type myotonia.
Lorenz, C., Meyer-Kleine, C., Steinmeyer, K., Koch, M.C. and Jentsch, T.J.
Human Molecular Genetics 3
(6): 941-946.
June 1994
Nonsense and missense mutations in the muscular chloride channel gene Clc-1 of myotonic mice.
Gronemeier, M., Condie, A., Prosser, J., Steinmeyer, K., Jentsch, T.J. and Jockusch, H.
Journal of Biological Chemistry 269
(8): 5963-5967.
25 February 1994
Multimeric structure of ClC-1 chloride channel revealed by mutations in dominant myotonia congenita (Thomsen).
Steinmeyer, K., Lorenz, C., Pusch, M., Koch, M.C. and Jentsch, T.J.
EMBO Journal 13
(4): 737-743.
15 February 1994
Trinity of cation channels.
Jentsch, T.J.
Nature 367
(6462): 412-413.
3 February 1994
Low single channel conductance of the major skeletal muscle chloride channel, ClC-1.
Pusch, M., Steinmeyer, K. and Jentsch, T.J.
Biophysical Journal 66
(1): 149-152.
January 1994
Molecular biology of voltage-gated chloride channels.
Jentsch, T.J.
Current Topics in Membranes 42
: 35-57.
1994
Structure and function of ClC chloride channels.
Jentsch, T.J.
Japanese Journal of Physiology 44
(Suppl 2): S1-S2.
1994
1993
The ClC family of voltage-gated chloride channels: structure and function.
Jentsch, T.J., Pusch, M., Rehfeldt, A. and Steinmeyer, K.
Annals of the New York Academy of Sciences 707
: 285-293.
20 December 1993
Evidence for genetic homogeneity in autosomal recessive generalised myotonia (Becker).
Koch, M.C., Ricker, K., Otto, M., Wolf, F., Zoll, B., Lorenz, C., Steinmeyer, K. and Jentsch, T.J.
Journal of Medical Genetics 30
(11): 914-917.
November 1993
Chloride channels.
Jentsch, T.J.
Current Opinion in Neurobiology 3
(3): 316-321.
June 1993
1992
Regions involved in the opening of CIC-2 chloride channel by voltage and cell volume.
Gruender, S., Thiemann, A., Pusch, M. and Jentsch, T.J.
Nature 360
(6406): 759-762.
24 December 1992
The skeletal muscle chloride channel in dominant and recessive human myotonia.
Koch, M.C., Steinmeyer, K., Lorenz, C., Ricker, K., Wolf, F., Otto, M., Zoll, B., Lehmann-Horn, F., Grzeschik, K.H. and Jentsch, T.J.
Science 257
(5071): 797-800.
7 August 1992
A chloride channel widely expressed in epithelial and non-epithelial cells.
Thiemann, A., Gruender, S., Pusch, M. and Jentsch, T.J.
Nature 356
(6364): 57-60.
5 March 1992
1991
Completely functional double-barreled chloride channel expressed from a single Torpedo cDNA.
Bauer, C.K., Steinmeyer, K., Schwarz, J.R. and Jentsch, T.J.
Proceedings of the National Academy of Sciences of the United States of America 88
(24): 11052-11056.
15 December 1991
Inactivation of muscle chloride channel by transposon insertion in myotonic mice.
Steinmeyer, K., Klocke, R., Ortland, C., Gronemeier, M., Jockusch, H., Gruender, S. and Jentsch, T.J.
Nature 354
(6351): 304-308.
28 November 1991
Primary structure and functional expression of a developmentally regulated skeletal muscle chloride channel.
Steinmeyer, K., Ortland, C. and Jentsch, T.J.
Nature 354
(6351): 301-304.
28 November 1991
1990
Primary structure of Torpedo marmorata chloride channel isolated by expression cloning in Xenopus oocytes.
Jentsch, T.J., Steinmeyer, K. and Schwarz, G.
Nature 348
(6301): 510-514.
6 December 1990
Cell culture of bovine corneal endothelial cells and its application to transport studies.
Wiederholt, M. and Jentsch, T.J.
Methods in Enzymology 192
: 571-582.
1990
1989
Primary structure of a novel 4-acetamido-4'-isothiocyanostilbene-2,2'-disulphonic acid (SITS)-binding membrane protein highly expressed in Torpedo californica electroplax.
Jentsch, T.J., Garcia, A.M. and Lodish, H.F.
Biochemical Journal 261
(1): 155-166.
1 July 1989
1988
Regulation of cytoplasmic pH of cultured bovine corneal endothelial cells in the absence and presence of bicarbonate.
Jentsch, T.J., Korbmacher, C., Janicke, I., Fischer, D.G., Stahl, F., Helbig, H., Hollwede, H., Cragoe, E.J., Keller, S.K. and Wiederholt, M.
Journal of Membrane Biology 103
(1): 29-40.
July 1988
Regulation of intracellular pH in cultured bovine retinal pigment epithelial cells.
Keller, S.K., Jentsch, T.J., Janicke, I. and Wiederholt, M.
Pfluegers Archiv European Journal of Physiology 411
(1): 47-52.
January 1988
1986
Electrical properties of sodium bicarbonate symport in kidney epithelial cells (BSC-1).
Jentsch, T.J., Matthes, H., Keller, S.K. and Wiederholt, M.
American Journal of Physiology 251
(6 Pt 2): F954-F968.
December 1986
The regulation of intracellular pH in monkey kidney epithelial cells (BSC-1). Roles of Na+/H+ antiport, Na+-HCO3(-)-(NaCO3-) symport, and Cl-/HCO3- exchange.
Jentsch, T.J., Janicke, I., Sorgenfrei, D., Keller, S.K. and Wiederholt, M.
Journal of Biological Chemistry 261
(26): 12120-12127.
15 September 1986
Kinetic properties of the sodium bicarbonate (carbonate) symport in monkey kidney epithelial cells (BSC-1). Interactions between Na+, HCO-3, and pH.
Jentsch, T.J., Schwartz, P., Schill, B.S., Langner, B., Lepple, A.P., Keller, S.K. and Wiederholt, M.
Journal of Biological Chemistry 261
(23): 10673-10679.
15 August 1986
Interactions of pH and K+ conductance in cultured bovine retinal pigment epithelial cells.
Keller, S.K., Jentsch, T.J., Koch, M. and Wiederholt, M.
American Journal of Physiology 250
(1 Pt 1): C124-C137.
January 1986
1985
Kidney epithelial cells of monkey origin (BSC-1) express a sodium bicarbonate cotransport. Characterization by 22Na+ flux measurements.
Jentsch, T.J., Schill, B.S., Schwartz, P., Matthes, H., Keller, S.K. and Wiederholt, M.
Journal of Biological Chemistry 260
(29): 15554-15560.
15 December 1985
Response of the intracellular potentials of cultured bovine lens cells to ions and inhibitors.
Jentsch, T.J., von der Haar, B., Keller, S.K. and Wiederholt, M.
Experimental Eye Research 41
(2): 131-144.
August 1985
Observation of doubly charged triatomic cluster ions in field evaporation.
Drachsel, W., Jentsch, T.J., Gingerich, K.A. and Block, J.H.
Surface Science 156
(Pt 1): 173-182.
3 June 1985
Ion transport mechanisms in cultured bovine corneal endothelial cells.
Jentsch, T.J., Keller, S.K. and Wiederholt, M.
Current Eye Research 4
(4): 361-369.
April 1985
Electrogenic sodium-bicarbonate symport in cultured corneal endothelial cells.
Wiederholt, M., Jentsch, T.J. and Keller, S.K.
Pfluegers Archiv European Journal of Physiology 405
(Suppl 1): S167-S171.
March 1985
Anion dependence of electrical effects of bicarbonate and sodium on cultured bovine corneal endothelial cells.
Jentsch, T.J., Matthes, H., Keller, S.K. and Wiederholt, M.
Pfluegers Archiv European Journal of Physiology 403
(2): 175-185.
February 1985
A bicarbonate-dependent process inhibitable by disulfonic stilbenes and a Na+/H+ exchange mediate 22Na+ uptake into cultured bovine corneal endothelium.
Jentsch, T.J., Stahlknecht, T.R., Hollwede, H., Fischer, D.G., Keller, S.K. and Wiederholt, M.
Journal of Biological Chemistry 260
(2): 795-801.
25 January 1985
1984
Evidence for coupled transport of bicarbonate and sodium in cultured bovine corneal endothelial cells.
Jentsch, T.J., Keller, S.K., Koch, M. and Wiederholt, M.
Journal of Membrane Biology 81
(3): 189-204.
October 1984
The calcium antagonist nisoldipine stimulates the electrolyte transport of the isolated frog skin.
Wiederholt, M., Keller, S., Krolik, A. and Jentsch, T.J.
Biochemical Pharmacology 33
(18): 2926-2928.
15 September 1984
Effect of bicarbonate, pH, methazolamide and stilbenes on the intracellular potentials of cultured bovine corneal endothelial cells.
Jentsch, T.J., Koch, M., Bleckmann, H. and Wiederholt, M.
Journal of Membrane Biology 78
(2): 103-117.
June 1984
1983
New techniques in surface specific mass analysis by photon induced field desorption.
Drachsel, W., Jentsch, T.J. and Block, J.H.
International Journal of Mass Spectrometry and Ion Physics 46
: 293-296.
January 1983
1982
Stability of doubly charged homonuclear trimeric metal clusters.
Jentsch, T.J., Drachsel, W. and Block, J.H.
Chemical Physics Letters 93
(2): 144-147.
26 November 1982
1981
Post-field ionization of singly charged rhodium: An experimental and theoretical study.
Ernst, N. and Jentsch, T.J.
Physical Review B 24
(11): 6234-6241.
July 1981
Copper cluster ions in photon-induced field ionization mass spectra.
Jentsch, T.J., Drachsel, W. and Block, J.H.
International Journal of Mass Spectrometry and Ion Physics 38
(2-3): 215-222.
May 1981
Signal shapes observed in photon-induced field ionization mass spectra.
Block, J.H., Jentsch, T.J. and Drachsel, W.
International Journal of Mass Spectrometry and Ion Physics 38
(2-3): 195-213.
May 1981
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