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CLC chloride channels and transporters

Item Type:Review
Title:CLC chloride channels and transporters
Creators Name:Jentsch, T.J., Neagoe, I. and Scheel, O.
Abstract:CLC proteins are found in cells from prokaryotes to mammals and perform functions in plasma membranes and intracellular vesicles. Several genetic human diseases and mouse models underscore their broad physiological functions in mammals. These functions range from the control of excitability to transepithelial transport, endocytotic trafficking and acidification of synaptic vesicles. The recent crystallization of bacterial CLC proteins gave surprising insights into CLC Cl(-)-channel permeation and gating and provides an excellent basis for structure-function studies. Surprisingly, the CLC from Escherichia coli functions as a Cl-/H+ exchanger, thus demonstrating the thin line separating transporters and channels.
Keywords:Chloride Channels, Ion Channel Gating, Membrane Transport Proteins, Structure-Activity Relationship, Animals, Mice
Source:Current Opinion in Neurobiology
Publisher:Current Biology
Page Range:319-325
Date:June 2005
Official Publication:https://doi.org/10.1016/j.conb.2005.05.002
PubMed:View item in PubMed

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