Browse by Journal Title

2024

Directed and acyclic synaptic connectivity in the human layer 2-3 cortical microcircuit.
Peng, Y., Bjelde, A., Aceituno, P.V., Mittermaier, F.X., Planert, H., Grosser, S., Onken, J., Faust, K., Kalbhenn, T., Simon, M., Radbruch, H., Fidzinski, P., Schmitz, D., Alle, H., Holtkamp, M., Vida, I., Grewe, B.F. and Geiger, J.R.P.
Science 384 (6693): 338-343. 26 April 2024

Touch sensation requires the mechanically gated ion channel ELKIN1.
Chakrabarti, S., Klich, J.D., Khallaf, M.A., Hulme, A.J., Sánchez-Carranza, O., Baran, Z.M., Rossi, A., Huang, A.T.L., Pohl, T., Fleischer, R., Fürst, C., Hammes, A., Bégay, V., Hörnberg, H., Finol-Urdaneta, R.K., Poole, K., Dottori, M. and Lewin, G.
Science 383 (6686): 992-998. 1 March 2024

2023

Phosphatidylinositol 3,5-bisphosphate facilitates axonal vesicle transport and presynapse assembly.
Rizalar, F.S., Lucht, M.T., Petzoldt, A., Kong, S., Sun, J., Vines, J.H., Telugu, N.S., Diecke, S., Kaas, T., Bullmann, T., Schmied, C., Löwe, D., King, J.S., Cho, W., Hallermann, S., Puchkov, D., Sigrist, S.J. and Haucke, V.
Science 382 (6667): 223-230. 12 October 2023

Immune-mediated denervation of the pineal gland underlies sleep disturbance in cardiac disease.
Ziegler, K.A., Ahles, A., Dueck, A., Esfandyari, D., Pichler, P., Weber, K., Kotschi, S., Bartelt, A., Sinicina, I., Graw, M., Leonhardt, H., Weckbach, L.T., Massberg, S., Schifferer, M., Simons, M., Hoeher, L., Luo, J., Ertürk, A., Schiattarella, G.G., Sassi, Y., Misgeld, T. and Engelhardt, S.
Science 381 (6655): 285-290. 21 July 2023

Brassinosteroid gene regulatory networks at cellular resolution in the Arabidopsis root.
Nolan, T.M., Vukašinović, N., Hsu, C.W., Zhang, J., Vanhoutte, I., Shahan, R., Taylor, I.W., Greenstreet, L., Heitz, M., Afanassiev, A., Wang, P., Szekely, P., Brosnan, A., Yin, Y., Schiebinger, G., Ohler, U., Russinova, E. and Benfey, P.N.
Science 379 (6639): eadf4721. 31 March 2023

2022

A noncoding single-nucleotide polymorphism at 8q24 drives IDH1-mutant glioma formation.
Yanchus, C., Drucker, K.L., Kollmeyer, T.M., Tsai, R., Winick-Ng, W., Liang, M., Malik, A., Pawling, J., De Lorenzo, S.B., Ali, A., Decker, P.A., Kosel, M.L., Panda, A., Al-Zahrani, K.N., Jiang, L., Browning, J.W.L., Lowden, C., Geuenich, M., Hernandez, J.J., Gosio, J.T., Ahmed, M., Loganathan, S.K., Berman, J., Trcka, D., Michealraj, K.A., Fortin, J., Carson, B., Hollingsworth, E.W., Jacinto, S., Mazrooei, P., Zhou, L., Elia, A., Lupien, M., He, H.H., Murphy, D.J., Wang, L., Abyzov, A., Dennis, J.W., Maass, P.G., Campbell, K., Wilson, M.D., Lachance, D.H., Wrensch, M., Wiencke, J., Mak, T., Pennacchio, L.A., Dickel, D.E., Visel, A., Wrana, J., Taylor, M.D., Zadeh, G., Dirks, P., Eckel-Passow, J.E., Attisano, L., Pombo, A., Ida, C.M., Kvon, E.Z., Jenkins, R.B. and Schramek, D.
Science 378 (6615): 68-78. 7 October 2022

Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies.
Reichart, D., Lindberg, E.L., Maatz, H., Miranda, A.M.A., Viveiros, A., Shvetsov, N., Gärtner, A., Nadelmann, E.R., Lee, M., Kanemaru, K., Ruiz-Orera, J., Strohmenger, V., DeLaughter, D.M., Patone, G., Zhang, H., Woehler, A., Lippert, C., Kim, Y., Adami, E., Gorham, J.M., Barnett, S.N., Brown, K., Buchan, R.J., Chowdhury, R.A., Constantinou, C., Cranley, J., Felkin, L.E., Fox, H., Ghauri, A., Gummert, J., Kanda, M., Li, R., Mach, L., McDonough, B., Samari, S., Shahriaran, F., Yapp, C., Stanasiuk, C., Theotokis, P.I., Theis, F.J., van den Bogaerdt, A., Wakimoto, H., Ware, J.S., Worth, C.L., Barton, P.J.R., Lee, Y.A., Teichmann, S.A., Milting, H., Noseda, M., Oudit, G.Y., Heinig, M., Seidman, J.G., Hubner, N. and Seidman, C.E.
Science 377 (6606): eabo1984. 5 August 2022

Pathogen-sugar interactions revealed by universal saturation transfer analysis.
Buchanan, C.J., Gaunt, B., Harrison, P.J., Yang, Y., Liu, J., Khan, A., Giltrap, A.M., Le Bas, A., Ward, P.N., Gupta, K., Dumoux, M., Tan, T.K., Schimaski, L., Daga, S., Picchiotti, N., Baldassarri, M., Benetti, E., Fallerini, C., Fava, F., Giliberti, A., Koukos, P.I., Davy, M.J., Lakshminarayanan, A., Xue, X., Papadakis, G., Deimel, L.P., Casablancas-Antràs, V., Claridge, T.D.W., Bonvin, A.M.J.J., Sattentau, Q.J., Furini, S., Gori, M., Huo, J., Owens, R.J., Schaffitzel, C., Berger, I., Renieri, A., Naismith, J.H., Baldwin, A.J. and Davis, B.G.
Science 377 (6604): eabm3125. 22 July 2022

Fly Cell Atlas: a single-nucleus transcriptomic atlas of the adult fruit fly.
Li, H., Janssens, J., De Waegeneer, M., Kolluru, S.S., Davie, K., Gardeux, V., Saelens, W., David, F.P.A., Brbić, M., Spanier, K., Leskovec, J., McLaughlin, C.N., Xie, Q., Jones, R.C., Brueckner, K., Shim, J., Tattikota, S.G., Schnorrer, F., Rust, K., Nystul, T.G., Carvalho-Santos, Zi., Ribeiro, C., Pal, S., Mahadevaraju, S., Przytycka, T.M., Allen, A.M., Goodwin, S.F., Berry, C.W., Fuller, M.T., White-Cooper, H., Matunis, E.L., DiNardo, S., Galenza, A., O'Brien, L.E., Dow, J.A.T., Jasper, H., Oliver, B., Perrimon, N., Deplancke, B., Quake, S.R., Luo, L. and Aerts, S.
Science 375 (6584): eabk2432. 4 March 2022

SARS-CoV-2 Beta variant infection elicits potent lineage-specific and cross-reactive antibodies.
Reincke, S.M., Yuan, M., Kornau, H.C., Corman, V.M., van Hoof, S., Sánchez-Sendin, E., Ramberger, M., Yu, W., Hua, Y., Tien, H., Schmidt, M.L., Schwarz, T., Jeworowski, L.M., Brandl, S.E., Rasmussen, H.F., Homeyer, M.A., Stöffler, L., Barner, M., Kunkel, D., Huo, S., Horler, J., von Wardenburg, N., Kroidl, I., Eser, T.M., Wieser, A., Geldmacher, C., Hoelscher, M., Gänzer, H., Weiss, G., Schmitz, D., Drosten, C., Prüss, H., Wilson, I.A. and Kreye, J.
Science 375 (6582): 782-787. 18 February 2022

2021

Cross-reactive CD4(+) T cells enhance SARS-CoV-2 immune responses upon infection and vaccination.
Loyal, L., Braun, J., Henze, L., Kruse, B., Dingeldey, M., Reimer, U., Kern, F., Schwarz, T., Mangold, M., Unger, C., Dörfler, F., Kadler, S., Rosowski, J., Gürcan, K., Uyar-Aydin, Z., Frentsch, M., Kurth, F., Schnatbaum, K., Eckey, M., Hippenstiel, S., Hocke, A., Müller, M.A., Sawitzki, B., Miltenyi, S., Paul, F., Mall, M.A., Wenschuh, H., Voigt, S., Drosten, C., Lauster, R., Lachman, N., Sander, L.E., Corman, V.M., Röhmel, J., Meyer-Arndt, L., Thiel, A. and Giesecke-Thiel, C.
Science 374 (6564): eabh1823. 8 October 2021

Haplotype-resolved diverse human genomes and integrated analysis of structural variation.
Ebert, P., Audano, P. A., Zhu, Q., Rodriguez-Martin, B., Porubsky, D., Bonder, M.J., Sulovari, A., Ebler, J., Zhou, W., Serra Mari, R., Yilmaz, F., Zhao, X., Hsieh, P.H., Lee, J., Kumar, S., Lin, J., Rausch, T., Chen, Y., Ren, J., Santamarina, M., Höps, W., Ashraf, H., Chuang, N.T., Yang, X., Munson, K.M., Lewis, A.P., Fairley, S., Tallon, L.J., Clarke, W.E., Basile, A.O., Byrska-Bishop, M., Corvelo, A., Evani, U.S., Lu, T.Y., Chaisson, M.J.P., Chen, J., Li, C., Brand, H., Wenger, A.M., Ghareghani, M., Harvey, W.T., Raeder, B., Hasenfeld, P., Regier, A.A., Abel, H.J., Hall, I.M., Flicek, P., Stegle, O., Gerstein, M.B, Tubio, J.M.C., Mu, Z., Li, Y.I., Shi, X., Hastie, A.R., Ye, K., Chong, Z., Sanders, A.D., Zody, M.C., Talkowski, M.E., Mills, R. E., Devine, S.E., Lee, C., Korbel, J.O., Marschall, T. and Eichler, E.E.
Science 372 (6537): eabf7117. 25 February 2021

Cultural transmission of vocal dialect in the naked mole-rat.
Barker, A.J., Veviurko, G., Bennett, N.C., Hart, D.W., Mograby, L. and Lewin, G.R.
Science 371 (6528): 503-507. 29 January 2021

2020

Sequence diversity analyses of an improved rhesus macaque genome enhance its biomedical utility.
Warren, W.C., Harris, R.A., Haukness, M., Fiddes, I.T., Murali, S.C., Fernandes, J., Dishuck, P.C., Storer, J.M, Raveendran, M., Hillier, L.W., Porubsky, D., Mao, Y., Gordon, D., Vollger, M.R., Lewis, A.P., Munson, K.M., DeVogelaere, E., Armstrong, J., Diekhans, M., Walker, J.A., Tomlinson, C., Graves-Lindsay, T.A., Kremitzki, M., Salama, S.R., Audano, P.A., Escalona, M., Maurer, N.W., Antonacci, F., Mercuri, L., Maggiolini, F.A.M., Catacchio, C.R., Underwood, J.G., O'Connor, D.H., Sanders, A.D., Korbel, J.O., Ferguson, B., Kubisch, H.M., Picker, L., Kalin, N.H., Rosene, D., Levine, J., Abbott, D.H., Gray, S.B., Sanchez, M.M., Kovacs-Balint, Z.A., Kemnitz, J.W., Thomasy, S.M., Roberts, J.A., Kinnally, E.L., Capitanio, J.P., Skene, J.H.Pate, Platt, M., Cole, S.A., Green, R.E., Ventura, M., Wiseman, R.W., Paten, B., Batzer, M.A., Rogers, J. and Eichler, E.E.
Science 370 (6523): eabc6617. 18 December 2020

Mouse embryonic stem cells self-organize into trunk-like structures with neural tube and somites.
Veenvliet, J.V., Bolondi, A., Kretzmer, H., Haut, L., Scholze-Wittler, M., Schifferl, D., Koch, F., Guignard, L., Kumar, A.S., Pustet, M., Heimann, S., Buschow, R., Wittler, L., Timmermann, B., Meissner, A. and Herrmann, B.G.
Science 370 (6522): eaba4937. 11 December 2020

The mole genome reveals regulatory rearrangements associated with adaptive intersexuality.
Real, F.M., Haas, S.A., Franchini, P., Xiong, P., Simakov, O., Kuhl, H., Schöpflin, R., Heller, D., Moeinzadeh, M.H., Heinrich, V., Krannich, T., Bressin, A., Hartmann, M.F., Wudy, S.A., Dechmann, D.K.N., Hurtado, A., Barrionuevo, F.J., Schindler, M., Harabula, I., Osterwalder, M., Hiller, M., Wittler, L., Visel, A., Timmermann, B., Meyer, A., Vingron, M., Jiménez, R., Mundlos, S. and Lupiáñez, D.G.
Science 370 (6513): 208-214. 9 October 2020

Importin α3 regulates chronic pain pathways in peripheral sensory neurons.
Marvaldi, L., Panayotis, N., Alber, S., Dagan, S.Y., Okladnikov, N., Koppel, I., Di Pizio, A., Song, D.A., Tzur, Y., Terenzio, M., Rishal, I., Gordon, D., Rother, F., Hartmann, E., Bader, M. and Fainzilber, M.
Science 369 (6505): 842-846. 14 August 2020

Fine-tuning stemness.
Borsa, M. and Simon, A.K.
Science 369 (6502): 373-374. 24 July 2020

Therapeutic targeting of preleukemia cells in a mouse model of mutant acute myeloid leukemia.
Uckelmann, H.J., Kim, S.M., Wong, E.M., Hatton, C., Giovinazzo, H., Gadrey, J.Y., Krivtsov, A.V., Rücker, F.G., Döhner, K., McGeehan, G.M., Levine, R.L., Bullinger, L., Vassiliou, G.S. and Armstrong, S.A.
Science 367 (6477): 586-590. 31 January 2020

2019

Rapid molecular evolution of pain insensitivity in multiple African rodents.
Eigenbrod, O., Debus, K.Y., Reznick, J., Bennett, N.C., Sánchez-Carranza, O., Omerbašić, D., Hart, D.W., Barker, A.J., Zhong, W., Lutermann, H., Katandukila, J.V., Mgode, G., Park, T.J. and Lewin, G.R.
Science 364 (6443): 852-859. 31 May 2019

Deubiquitinase USP10 regulates Notch signaling in the endothelium.
Lim, R., Sugino, T., Nolte, H., Andrade, J., Zimmermann, B., Shi, C., Doddaballapur, A., Ong, Y.T., Wilhelm, K., Fasse, J.W.D., Ernst, A., Kaulich, M., Husnjak, K., Boettger, T., Guenther, S., Braun, T., Krüger, M., Benedito, R., Dikic, I. and Potente, M.
Science 364 (6436): 188-193. 12 April 2019

Mapping the lung.
Mildner, A. and Yona, S.
Science 363 (6432): 1154-1155. 15 March 2019

A pharmacological master key mechanism that unlocks the selectivity filter gate in K(+) channels.
Schewe, M., Sun, H., Mert, Ü., Mackenzie, A., Pike, A.C.W., Schulz, F., Constantin, C., Vowinkel, K.S., Conrad, L.J., Kiper, A.K., Gonzalez, W., Musinszki, M., Tegtmeier, M., Pryde, D.C., Belabed, H., Nazare, M., de Groot, B.L., Decher, N., Fakler, B., Carpenter, E.P., Tucker, S.J. and Baukrowitz, T.
Science 363 (6429): 875-880. 22 February 2019

BCR-dependent lineage plasticity in mature B cells.
Graf, R., Seagal, J., Otipoby, K.L., Lam, K.P., Ayoub, S., Zhang, B., Sander, S., Chu, V.T. and Rajewsky, K.
Science 363 (6428): 748-753. 15 February 2019

2018

A mechanistic classification of clinical phenotypes in neuroblastoma.
Ackermann, S., Cartolano, M., Hero, B., Welte, A., Kahlert, Y., Roderwieser, A., Bartenhagen, C., Walter, E., Gecht, J., Kerschke, L., Volland, R., Menon, R., Heuckmann, J.M., Gartlgruber, M., Hartlieb, S., Henrich, K.O., Okonechnikov, K., Altmüller, J., Nürnberg, P., Lefever, S., de Wilde, B., Sand, F., Ikram, F., Rosswog, C., Fischer, J., Theissen, J., Hertwig, F., Singhi, A.D., Simon, T., Vogel, W., Perner, S., Krug, B., Schmidt, M., Rahmann, S., Achter, V., Lang, U., Vokuhl, C., Ortmann, M., Büttner, R., Eggert, A., Speleman, F., O'Sullivan, R.J., Thomas, R.K., Berthold, F., Vandesompele, J., Schramm, A., Westermann, F., Schulte, J.H., Peifer, M. and Fischer, M.
Science 362 (6419): 1165-1170. 7 December 2018

Cell type atlas and lineage tree of a whole complex animal by single-cell transcriptomics.
Plass, M., Solana, J., Wolf, F.A., Ayoub, S., Misios, A., Glažar, P., Obermayer, B., Theis, F.J., Kocks, C. and Rajewsky, N.
Science 360 (6391): eaaq1723. 25 May 2018

Diverging roads to the heart.
Kelly, R.G. and Sperling, S.R.
Science 359 (6380): 1098-1099. 9 March 2018

2017

The Drosophila embryo at single-cell transcriptome resolution.
Karaiskos, N., Wahle, P., Alles, J., Boltengagen, A., Ayoub, S., Kipar, C., Kocks, C., Rajewsky, N. and Zinzen, R.P.
Science 358 (6360): 194-199. 13 October 2017

Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function.
Piwecka, M., Glažar, P., Hernandez-Miranda, L.R., Memczak, S., Wolf, S.A., Rybak-Wolf, A., Filipchyk, A., Klironomos, F., Cerda Jara, C.A., Fenske, P., Trimbuch, T., Zywitza, V., Plass, M., Schreyer, L., Ayoub, S., Kocks, C., Kühn, R., Rosenmund, C., Birchmeier, C. and Rajewsky, N.
Science 357 (6357): eaam8526. 22 September 2017

Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat.
Park, T.J., Reznick, J., Peterson, B.L., Blass, G., Omerbašić, D., Bennett, N.C., Kuich, P.H.J.L., Zasada, C., Browe, B.M., Hamann, W., Applegate, D.T., Radke, M.H., Kosten, T., Lutermann, H., Gavaghan, V., Eigenbrod, O., Bégay, V., Amoroso, V. G., Govind, V., Minshall, R.D., Smith, E.S.J., Larson, J., Gotthardt, M., Kempa, S. and Lewin, G.R.
Science 356 (6335): 307-311. 21 April 2017

2016

Microglia development follows a stepwise program to regulate brain homeostasis.
Matcovitch-Natan, O., Winter, D.R., Giladi, A., Vargas Aguilar, S., Spinrad, A., Sarrazin, S., Ben-Yehuda, H., David, E., Zelada González, F., Perrin, P., Keren-Shaul, H., Gury, M., Lara-Astaiso, D., Thaiss, C.A., Cohen, M., Bahar Halpern, K., Baruch, K., Deczkowska, A., Lorenzo-Vivas, E., Itzkovitz, S., Elinav, E., Sieweke, M.H., Schwartz, M. and Amit, I.
Science 353 (6301): aad8670. 19 August 2016

Crimea report leaves readers in the cold.
Goushcha, A., Goloverda, G.Z., Kotsyuba, O., Perepichka, D.F., Seumenicht, O. and Ladokhin, A.S.
Science 352 (6287): 780-781. 13 May 2016

Durable coexistence of donor and recipient strains after fecal microbiota transplantation.
Li, S.S., Zhu, A., Benes, V., Costea, P.I., Hercog, R., Hildebrand, F., Huerta-Cepas, J., Nieuwdorp, M., Salojaervi, J., Voigt, A.Y., Zeller, G., Sunagawa, S., de Vos, W.M. and Bork, P.
Science 352 (6285): 586-589. 29 April 2016

Single-vesicle imaging reveals different transport mechanisms between glutamatergic and GABAergic vesicles.
Farsi, Z., Preobraschenski, J., van den Bogaart, G., Riedel, D., Jahn, R. and Woehler, A.
Science 351 (6276): 981-984. 26 February 2016

Lineage-specific enhancers activate self-renewal genes in macrophages and embryonic stem cells.
Soucie, E.L., Weng, Z., Geirsdóttir, L., Molawi, K., Maurizio, J., Fenouil, R., Mossadegh-Keller, N., Gimenez, G., VanHille, L., Beniazza, M., Favret, J., Berruyer, C., Perrin, P., Hacohen, N., Andrau, J.C., Ferrier, P., Dubreuil, P., Sidow, A. and Sieweke, M.H.
Science 351 (6274): aad5510. 12 February 2016

2015

Operon structure and cotranslational subunit association direct protein assembly in bacteria.
Shieh, Y.W., Minguez, P., Bork, P., Auburger, J.J., Guilbride, D.L., Kramer, G. and Bukau, B.
Science 350 (6261): 678-680. 6 November 2015

Transcriptional control of tissue formation throughout root development.
Moreno-Risueno, M.A., Sozzani, R., Yardımcı, G.G., Petricka, J.J., Vernoux, T., Blilou, I., Alonso, J., Winter, C.M., Ohler, U., Scheres, B. and Benfey, P.N.
Science 350 (6259): 426-430. 23 October 2015

Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy.
Hinson, J.T., Chopra, A., Nafissi, N., Polacheck, W.J., Benson, C.C., Swist, S., Gorham, J., Yang, L., Schafer, S., Sheng, C.C., Haghighi, A., Homsy, J., Hubner, N., Church, G., Cook, S.A., Linke, W.A., Chen, C.S., Seidman, J.G. and Seidman, C.E.
Science 349 (6251): 982-986. 28 August 2015

Patterns and ecological drivers of ocean viral communities.
Brum, J.R., Ignacio-Espinoza, J.C., Roux, S., Doulcier, G., Acinas, S.G., Alberti, A., Chaffron, S., Cruaud, C., de Vargas, C., Gasol, J.M., Gorsky, G., Gregory, A.C., Guidi, L., Hingamp, P., Iudicone, D., Not, F., Ogata, H., Pesant, S., Poulos, B.T., Schwenck, S.M., Speich, S., Dimier, C., Kandels-Lewis, S., Picheral, M., Searson, S., Bork, P., Bowler, C., Sunagawa, S., Wincker, P., Karsenti, E. and Sullivan, M.B.
Science 348 (6237): 1261498. 22 May 2015

Determinants of community structure in the global plankton interactome.
Lima-Mendez, G., Faust, K., Henry, N., Decelle, J., Colin, S., Carcillo, F., Chaffron, S., Ignacio-Espinosa, J.C., Roux, S., Vincent, F., Bittner, L., Darzi, Y., Wang, J., Audic, S., Berline, L., Bontempi, G., Cabello, A.M., Coppola, L., Cornejo-Castillo, F.M., d' Ovidio, F., De Meester, L., Ferrera, I., Garet-Delmas, M.J., Guidi, L., Lara, E., Pesant, S., Royo-Llonch, M., Salazar, G., Sanchez, P., Sebastian, M., Souffreau, C., Dimier, C., Picheral, M., Searson, S., Kandels-Lewis, S., Gorsky, G., Not, F., Ogata, H., Speich, S., Stemmann, L., Weissenbach, J., Wincker, P., Acinas, S.G., Sunagawa, S., Bork, P., Sullivan, M.B., Karsenti, E., Bowler, C., de Vargas, C. and Raes, J.
Science 348 (6237): 1262073. 22 May 2015

Structure and function of the global ocean microbiome.
Sunagawa, S., Coelho, L.P., Chaffron, S., Kultima, J.R., Labadie, K., Salazar, G., Djahanschiri, B., Zeller, G., Mende, D.R., Alberti, A., Cornejo-Castillo, F.M., Costea, P.I., Cruaud, C., d'Ovidio, F., Engelen, S., Ferrera, I., Gasol, J.M., Guidi, L., Hildebrand, F., Kokoszka, F., Lepoivre, C., Lima-Mendez, G., Poulain, J., Poulos, B.T., Royo-Llonch, M., Sarmento, H., Vieira-Silva, S., Dimier, C., Picheral, M., Searson, S., Kandels-Lewis, S., Bowler, C., de Vargas, C., Gorsky, G., Grimsley, N., Hingamp, P., Iudicone, D., Jaillon, O., Not, F., Ogata, H., Pesant, S., Speich, S., Stemmann, L., Sullivan, M.B., Weissenbach, J., Wincker, P., Karsenti, E., Raes, J., Acinas, S.G. and Bork, P.
Science 348 (6237): 1261359. 22 May 2015

Environmental characteristics of Agulhas rings affect interocean plankton transport.
Villar, E., Farrant, G.K., Follows, M., Garczarek, L., Speich, S., Audic, S., Bittner, L., Blanke, B., Brum, J.R., Brunet, C., Casotti, R., Chase, A., Dolan, J.R., d'Ortenzio, F., Gattuso, J.P., Grima, N., Guidi, L., Hill, C.N., Jahn, O., Jamet, J.L., Le Goff, H., Lepoivre, C., Malviya, S., Pelletier, E., Romagnan, J.B., Roux, S., Santini, S., Scalco, E., Schwenck, S.M., Tanaka, A., Testor, P., Vannier, T., Vincent, F., Zingone, A., Dimier, C., Picheral, M., Searson, S., Kandels-Lewis, S., Acinas, S.G., Bork, P., Boss, E., de Vargas, C., Gorsky, G., Ogata, H., Pesant, S., Sullivan, M.B., Sunagawa, S., Wincker, P., Karsenti, E., Bowler, C., Not, F., Hingamp, P. and Iudicone, D.
Science 348 (6237): 1261447. 22 May 2015

Eukaryotic plankton diversity in the sunlit ocean.
de Vargas, C., Audic, S., Henry, N., Decelle, J., Mahe, F., Logares, R., Lara, E., Berney, C., Le Bescot, N., Probert, I., Carmichael, M., Poulain, J., Romac, S., Colin, S., Aury, J.M., Bittner, L., Chaffron, S., Dunthorn, M., Engelen, S., Flegontova, O., Guidi, L., Horak, A., Jaillon, O., Lima-Mendez, G., Lukes, J., Malviya, S., Morard, R., Mulot, M., Scalco, E., Siano, R., Vincent, F., Zingone, A., Dimier, C., Picheral, M., Searson, S., Kandels-Lewis, S., Acinas, S.G., Bork, P., Bowler, C., Gorsky, G., Grimsley, N., Hingamp, P., Iudicone, D., Not, F., Ogata, H., Pesant, S., Raes, J., Sieracki, M.E., Speich, S., Stemmann, L., Sunagawa, S., Weissenbach, J., Wincker, P. and Karsenti, E.
Science 348 (6237): 1261605. 22 May 2015

Dynamic profiling of the protein life cycle in response to pathogens.
Jovanovic, M., Rooney, M.S., Mertins, P., Przybylski, D., Chevrier, N., Satija, R., Rodriguez, E.H., Fields, A.P., Schwartz, S., Raychowdhury, R., Mumbach, M.R., Eisenhaure, T., Rabani, M., Gennert, D., Lu, D., Delorey, T., Weissman, J.S., Carr, S.A., Hacohen, N. and Regev, A.
Science 347 (6226): 1259038. 6 March 2015

Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells.
Arner, E., Daub, C.O., Vitting-Seerup, K., Andersson, R., Lilje, B., Drabløs, F., Lennartsson, A., Rönnerblad, M., Hrydziuszko, O., Vitezic, M., Freeman, T.C., Alhendi, A., Arner, P., Axton, R., Baillie, J.K., Beckhouse, A., Bodega, B., Briggs, J., Brombacher, F., Davis, M., Detmar, M., Ehrlund, A., Endoh, M., Eslami, A., Fagiolini, M., Fairbairn, L., Faulkner, G.J., Ferrai, C., Fisher, M.E., Forrester, L., Goldowitz, D., Guler, R., Ha, T., Hara, M., Herlyn, M., Ikawa, T., Kai, C., Kawamoto, H., Khachigian, L., Klinken, P.S., Kojima, S., Koseki, H., Klein, S., Mejhert, N., Miyaguchi, K., Mizuno, Y., Morimoto, M., Morris, K.J., Mummery, C., Nakachi, Y., Ogishima, S., Okada-Hatakeyama, M., Okazaki, Y., Orlando, V., Ovchinnikov, D., Passier, R., Patrikakis, M., Pombo, A., Qin, X.Y., Roy, S., Sato, H., Savvi, S., Saxena, A., Schwegmann, A., Sugiyama, D., Swoboda, R., Tanaka, H., Tomoiu, A., Winteringham, L.N., Wolvetang, E., Yanagi-Mizuochi, C., Yoneda, M., Zabierowski, S., Zhang, P., Abugessaisa, I., Bertin, N., Diehl, A.D., Fukuda, S., Furuno, M., Harshbarger, J., Hasegawa, A., Hori, F., Ishikawa-Kato, S., Ishizu, Y., Itoh, M., Kawashima, T., Kojima, M., Kondo, N., Lizio, M., Meehan, T.F., Mungall, C.J., Murata, M., Nishiyori-Sueki, H., Sahin, S., Sato-Nagao, S., Severin, J., de Hoon, M.J., Kawai, J., Kasukawa, T., Lassmann, T., Suzuki, H., Kawaji, H., Summers, K.M., Wells, C., Hume, D.A., Forrest, A.R.R., Sandelin, A., Carninci, P. and Hayashizaki, Y.
Science 347 (6225): 1010-1014. 27 February 2015

2014

Structure of the large ribosomal subunit from human mitochondria.
Brown, A., Amunts, A., Bai, X.C., Sugimoto, Y., Edwards, P.C., Murshudov, G., Scheres, S.H.W. and Ramakrishnan, V.
Science 346 (6210): 718-722. 7 November 2014

Parasympathetic neurons originate from nerve-associated peripheral glial progenitors.
Dyachuk, V., Furlan, A., Shahidi, M.K., Giovenco, M., Kaukua, N., Konstantinidou, C., Pachnis, V., Memic, F., Marklund, U., Müller, T., Birchmeier, C., Fried, K., Ernfors, P. and Adameyko, I.
Science 345 (6192): 82-87. 4 July 2014

Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC.
Voss, F.K., Ullrich, F., Muench, J., Lazarow, K., Lutter, D., Mah, N., Andrade-Navarro, M.A., von Kries, J.P., Stauber, T. and Jentsch, T.J.
Science 344 (6184): 634-638. 9 May 2014

Complement is activated by IgG hexamers assembled at the cell surface.
Diebolder, C.A., Beurskens, F.J., de Jong, R.N., Koning, R.I., Strumane, K., Lindorfer, M.A., Voorhorst, M., Ugurlar, D., Rosati, S., Heck, A.J.R., van de Winkel, J.G.J., Wilson, I.A., Koster, A.J., Taylor, R.P., Saphire, E.O., Burton, D.R., Schuurman, J., Gros, P. and Parren, P.W.H.I
Science 343 (6176): 1260-3. 14 March 2014

2013

Beyond stem cells: self-renewal of differentiated macrophages.
Sieweke, M.H. and Allen, J.E.
Science 342 (6161): 1242974. 22 November 2013

Natural selection and pain meet at a sodium channel.
Lewin, G.R.
Science 342 (6157): 428-429. 25 October 2013

NextGen speaks.
Lacadie, S.A.
Science 340 (6128): 29. April 2013

Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching.
Di Virgilio, M., Callen, E., Yamane, A., Zhang, W., Jankovic, M., Gitlin, A.D., Feldhahn, N., Resch, W., Oliveira, T.Y., Chait, B.T., Nussenzweig, A., Casellas, R., Robbiani, D.F. and Nussenzweig, M.C.
Science 339 (6120): 711-715. 8 February 2013

2012

Segregation of axonal and somatic activity during fast network oscillations.
Dugladze, T., Schmitz, D., Whittington, M.A., Vida, I. and Gloveli, T.
Science 336 (6087): 1458-1461. 15 June 2012

p53 dynamics control cell fate.
Purvis, J.E., Karhohs, K.W., Mock, C., Batchelor, E., Loewer, A. and Lahav, G.
Science 336 (6087): 1440-1444. 15 June 2012

The transcription factor c-Maf controls touch receptor development and function.
Wende, H., Lechner, S.G., Cheret, C., Bourane, S., Kolanczyk, M.E., Pattyn, A., Reuter, K., Munier, F.L., Carroll, P., Lewin, G.R. and Birchmeier, C.
Science 335 (6074): 1373-1376. 16 March 2012

2011

RIM-binding protein, a central part of the active zone, is essential for neurotransmitter release.
Liu, K.S.Y., Siebert, M., Mertel, S., Knoche, E., Wegener, S., Wichmann, C., Matkovic, T., Muhammad, K., Depner, H., Mettke, C., Bueckers, J., Hell, S.W., Mueller, M., Davis, G.W., Schmitz, D. and Sigrist, S.J.
Science 334 (6062): 1565-1659. 16 December 2011

The molecular basis of acid insensitivity in the African naked mole-rat.
Smith, E.S.J., Omerbasic, D., Lechner, S.G., Anirudhan, G., Lapatsina, L. and Lewin, G.R.
Science 334 (6062): 1557-1560. 16 December 2011

Direct conversion of C. elegans germ cells into specific neuron types.
Tursun, B., Patel, T., Kratsios, P. and Hobert, O.
Science 331 (6015): 304-308. 21 January 2011

2010

Integrative analysis of the caenorhabditis elegans genome by the modENCODE project.
Gerstein, M.B., Lu, Z.J., Van Nostrand, E.L., Cheng, C., Arshinoff, B.I., Liu, T., Yip, K.Y., Robilotto, R., Rechtsteiner, A., Ikegami, K., Alves, P., Chateigner, A., Perry, M., Morris, M., Auerbach, R.K., Feng, X., Leng, J., Vielle, A., Niu, W., Rhrissorrakrai, K., Agarwal, A., Alexander, R.P., Barber, G., Brdlik, C.M., Brennan, J., Brouillet, J.J., Carr, A., Cheung, M.S., Clawson, H., Contrino, S., Dannenberg, L.O., Dernburg, A.F., Desai, A., Dick, L., Dose, A.C., Du, J., Egelhofer, T., Ercan, S., Euskirchen, G., Ewing, B., Feingold, E.A., Gassmann, R., Good, P.J., Green, P., Gullier, F., Gutwein, M., Guyer, M.S., Habegger, L., Han, T., Henikoff, J.G., Henz, S.R., Hinrichs, A., Holster, H., Hyman, T., Iniguez, A.L., Janette, J., Jensen, M., Kato, M., Kent, W.J., Kephart, E., Khivansara, V., Khurana, E., Kim, J.K., Kolasinska-Zwierz, P., Lai, E.C., Latorre, I., Leahey, A., Lewis, S., Lloyd, P., Lochovsky, L., Lowdon, R.F., Lubling, Y., Lyne, R., Maccoss, M., Mackowiak, S.D., Mangone, M., McKay, S., Mecenas, D., Merrihew, G., Miller, D.M., Muroyama, A., Murray, J.I., Ooi, S.L., Pham, H., Phippen, T., Preston, E.A., Rajewsky, N., Raetsch, G., Rosenbaum, H., Rozowsky, J., Rutherford, K., Ruzanov, P., Sarov, M., Sasidharan, R., Sboner, A., Scheid, P., Segal, E., Shin, H., Shou, C., Slack, F.J., Slightam, C., Smith, R., Spencer, W.C., Stinson, E.O., Taing, S., Takasaki, T., Vafeados, D., Voronina, K., Wang, G., Washington, N.L., Whittle, C.M., Wu, B., Yan, K.K., Zeller, G., Zha, Z., Zhong, M., Zhou, X., Ahringer, J., Strome, S., Gunsalus, K.C., Micklem, G., Liu, X.S., Reinke, V., Kim, S.K., Hillier, L.W., Henikoff, S., Piano, F., Snyder, M., Stein, L., Lieb, J.D. and Waterston, R.H.
Science 330 (6012): 1775-1787. 24 December 2010

The landscape of C. elegans 3'UTRs.
Mangone, M., Manoharan, A.P., Thierry-Mieg, D., Thierry-Mieg, J., Han, T., Mackowiak, S., Mis, E., Zegar, C., Gutwein, M.R., Khivansara, V., Attie, O., Chen, K., Salehi-Ashtiani, K., Vidal, M., Harkins, T.T., Bouffard, P., Suzuki, Y., Sugano, S., Kohara, Y., Rajewsky, N., Piano, F., Gunsalus, K.C. and Kim, J.K.
Science 329 (5990): 432-435. 23 July 2010

Endosomal chloride-proton exchange rather than chloride conductance is crucial for renal endocytosis.
Novarino, G., Weinert, S., Rickheit, G. and Jentsch, T.J.
Science 328 (5984): 1398-1401. 11 June 2010

Lysosomal pathology and osteopetrosis upon loss of H+-driven lysosomal Cl- accumulation.
Weinert, S., Jabs, S., Supanchart, C., Schweizer, M., Gimber, N., Richter, M., Rademann, J., Stauber, T., Kornak, U. and Jentsch, T.J.
Science 328 (5984): 1401-1403. 11 June 2010

Altered histone acetylation is associated with age-dependent memory impairment in mice.
Peleg, S., Sananbenesi, F., Zovoilis, A., Burkhardt, S., Bahari-Javan, S., Agis-Balboa, R.C., Cota, P., Wittnam, J.L., Gogol-Doering, A., Opitz, L., Salinas-Riester, G., Dettenhofer, M., Kang, H., Farinelli, L., Chen, W. and Fischer, A.
Science 328 (5979): 753-756. 7 May 2010

2009

Transcriptome complexity in a genome-reduced bacterium.
Gueell, M., van Noort, V., Yus, E., Chen, W.H., Leigh-Bell, J., Michalodimitrakis, K., Yamada, T., Arumugam, M., Doerks, T., Kuehner, S., Rode, M., Suyama, M., Schmidt, S., Gavin, A.C., Bork, P. and Serrano, L.
Science 326 (5957): 1268-1271. 27 November 2009

Proteome organization in a genome-reduced bacterium.
Kuehner, S., van Noort, V., Betts, M.J., Leo-Macias, A., Batisse, C., Rode, M., Yamada, T., Maier, T., Bader, S., Beltran-Alvarez, P., Castano-Diez, D., Chen, W.H., Devos, D., Gueell, M., Norambuena, T., Racke, I., Rybin, V., Schmidt, A., Yus, E., Aebersold, R., Herrmann, R., Boettcher, B., Frangakis, A.S., Russell, R.B., Serrano, L., Bork, P. and Gavin, A.C.
Science 326 (5957): 1235-1240. 27 November 2009

Impact of genome reduction on bacterial metabolism and its regulation.
Yus, E., Maier, T., Michalodimitrakis, K., van Noort, V., Yamada, T., Chen, W.H., Wodke, J.A., Gueell, M., Martinez, S., Bourgeois, R., Kuehner, S., Raineri, E., Letunic, I., Kalinina, O.V., Rode, M., Herrmann, R., Gutierrez-Gallego, R., Russell, R.B., Gavin, A.C., Bork, P. and Serrano, L.
Science 326 (5957): 1263-1268. 27 November 2009

MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice.
Bonauer, A., Carmona, G., Iwasaki, M., Mione, M., Koyanagi, M., Fischer, A., Burchfield, J., Fox, H., Doebele, C., Ohtani, K., Chavakis, E., Potente, M., Tjwa, M., Urbich, C., Zeiher, A.M. and Dimmeler, S.
Science 324 (5935): 1710-1713. 26 June 2009

Ligand-dependent equilibrium fluctuations of single calmodulin molecules.
Junker, J.P., Ziegler, F. and Rief, M.
Science 323 (5914): 633-637. 30 January 2009

2008

Biochemistry. Not comparable, but complementary.
Jensen, L.J. and Bork, P.
Science 322 (5898): 56-57. 3 October 2008

Drug target identification using side-effect similarity.
Campillos, M., Kuhn, M., Gavin, A.C., Jensen, L.J. and Bork, P.
Science 321 (5886): 263-266. 11 July 2008

Subdiffraction multicolor imaging of the nuclear periphery with 3D structured illumination microscopy.
Schermelleh, L., Carlton, P.M., Haase, S., Shao, L., Winoto, L., Kner, P., Burke, B., Cardoso, M.C., Agard, D.A., Gustafsson, M.G., Leonhardt, H. and Sedat, J.W.
Science 320 (5881): 1332-1336. 6 June 2008

Neuroscience : Rules of plasticity.
Brecht, M. and Schmitz, D.
Science 319 (5859): 39-40. 4 January 2008

2007

Genome-wide experimental determination of barriers to horizontal gene transfer.
Sorek, R., Zhu, Y., Creevey, C.J., Francino, M.P., Bork, P. and Rubin, E.M.
Science 318 (5855): 1449-1452. 30 November 2007

A high-resolution root spatiotemporal map reveals dominant expression patterns.
Brady, S.M., Orlando, D.A., Lee, J.Y., Wang, J.Y., Koch, J., Dinneny, J.R., Mace, D., Ohler, U. and Benfey, P.N.
Science 318 (5851): 801-806. 2 November 2007

Regulation of the germinal center response by microRNA-155.
Thai, T.H., Calado, D.P., Casola, S., Ansel, K.M., Xiao, C., Xue, Y., Murphy, A., Frendewey, D., Valenzuela, D., Kutok, J.L., Schmidt-Supprian, M., Rajewsky, N., Yancopoulos, G., Rao, A. and Rajewsky, K.
Science 316 (5824): 604-608. 27 April 2007

Quantitative phylogenetic assessment of microbial communities in diverse environments.
von Mering, C., Hugenholtz, P., Raes, J., Tringe, S.G., Doerks, T., Jensen, L.J., Ward, N. and Bork, P.
Science 315 (5815): 1126-1130. 23 February 2007

2006

Control of peripheral nerve myelination by the β-secretase BACE1.
Willem, M., Garratt, A.N., Novak, B., Citron, M., Kaufmann, S., Rittger, A., Destrooper, B., Saftig, P., Birchmeier, C. and Haass, C.
Science 314 (5799): 664-666. 27 October 2006

Platelet-derived serotonin mediates liver regeneration.
Lesurtel, M., Graf, R., Aleil, B., Walther, D.J., Tian, Y., Jochum, W., Gachet, C., Bader, M. and Clavien, P.A.
Science 312 (5770): 104-107. 7 April 2006

Toward automatic reconstruction of a highly resolved tree of life.
Ciccarelli, F.D., Doerks, T., von Mehring, C., Creevey, C.J., Snel, B. and Bork, P.
Science 311 (5765): 1283-1287. 3 March 2006

The cellular basis of a corollary discharge.
Poulet, J.F.A. and Hedwig, B.
Science 311 (5760): 518-522. 27 January 2006

2005

Vertebrate-type intron-rich genes in the marine annelid Platynereis dumerilii.
Raible, F., Tessmar-Raible, K., Osoegawa, K., Wincker, P., Jubin, C., Balavoine, G., Ferrier, D., Benes, V., de Jong, P., Weissenbach, J., Bork, P. and Arendt, D.
Science 310 : 1325-1326. 25 November 2005

The transcriptional landscape of the mammalian genome.
Carninci, P., Kasukawa, T., Katayama, S., Gough, J., Frith, M.C., Maeda, N., Oyama, R., Ravasi, T., Lenhard, B., Wells, C., Kodzius, R., Shimokawa, K., Bajic, V.B., Brenner, S.E., Batalov, S., Forrest, A.R.R., Zavolan, M., Davis, M.J., Wilming, L.G., Aidinis, V., Allen, J.E., Ambesi-Impiombato, A., Apweiler, R., Aturaliya, R.N., Bailey, T.L., Bansal, M., Baxter, L., Beisel, K.W., Bersano, T., Bono, H., Chalk, A.M., Chiu, K.P., Choudhary, V., Christoffels, A., Clutterbuck, D.R., Crowe, M.L., Dalla, E., Dalrymple, B.P., de Bono, B., Della Gatta, G., di Bernardo, D., Down, T., Engstrom, P., Fagiolini, M., Faulkner, G., Fletcher, C.F., Fukushima, T., Furuno, M., Futaki, S., Gariboldi, M., Georgii-Hemming, P., Gingeras, G.R., Gojobori, T., Green, R.E., Gustincich, S., Harbers, M., Hayashi, Y., Hensch, T.K., Hirokawa, N., Hill, D., Huminiecki, L., Iacono, I., Ikeo, K., Iwama, A., Ishikawa, T., Jakt, M., Kanapin, A., Katoh, M., Kawasawa, Y., Kelso, J., Kitamura, H., Kitano, H., Kollias, G., Krishnan, S.P.T., Kruger, A., Kummerfeld, S.K., Kurochkin, I.V., Lareau, L.F., Lazarevic, D., Lipovich, L., Liu, J., Liuni, S., McWilliam, S., Madan Babu, M., Madera, M., Marchionni, L., Matsuda, H., Matsuzawa, S., Miki, H., Mignone, F., Miyake, S., Morris, K., Mottagui-Tabar, S., Mulder, N., Nakano, N., Nakauchi, H., Ng, P., Nilsson, R., Nishiguchi, S., Nishikawa, S., Nori, F., Ohara, O., Okazaki, Y., Orlando, V., Pang, K.C., Pavan, W.J., Pavesi, G., Pesole, G., Petrovsky, N., Piazza, S., Reed, J., Reid, J.F., Ring, B.Z., Ringwald, M., Rost, B., Ruan, Y., Salzberg, S.L., Sandelin, A., Schneider, C., Schönbach, C., Sekiguchi, S., Semple, C.A.M., Seno, S., Sessa, L., Sheng, Y., Shibata, Y., Shimada, H., Shimada, K., Silva, D., Sinclair, B., Sperling, S., Stupka, E., Sugiura, S., Sultana, R., Takenaka, Y., Taki, K., Tammoja, K., Tan, S.L., Tang, S., Taylor, M.S., Tegner, J., Teichmann, S.A., Ueda, H.R., van Nimwegen, E., Verardo, R., Wei, C.L., Yagi, K., Yamanishi, H., Zabarovsky, E., Zhu, S., Zimmer, A., Hide, W., Bult, C., Grimmond, S.M., Teasdale, R.D., Liu, E.T., Brusic, V., Quackenbush, J., Wahlestedt, C., Mattick, J.S., Hume, D.A., Kai, C., Sasaki, D., Tomaru, Y., Fukuda, S., Kanamori-Katayama, M., Suzuki, M., Aoki, J., Arakawa, T., Iida, J., Imamura, K., Itoh, M., Kato, T., Kawaji, H., Kawagashira, N., Kawashima, T., Kojima, M., Kondo, S., Konno, H., Nakano, K., Ninomiya, N., Nishio, T., Okada, M., Plessy, C., Shibata, K., Shiraki, T., Suzuki, S., Tagami, M., Waki, K., Watahiki, A., Okamura-Oho, Y., Suzuki, H., Kawai, J. and Hayashizaki, Y.
Science 309 (5740): 1559-1563. 2 September 2005

An acylation cycle regulates localization and activity of palmitoylated Ras isoforms.
Rocks, O., Peyker, A., Kahms, M., Verveer, P.J., Koerner, C., Lumbierres, M., Kuhlmann, J., Waldmann, H., Wittinghofer, A. and Bastiaens, P.I.
Science 307 (5716): 1746-1752. 18 March 2005

Dynamic complex formation during the yeast cell cycle.
de Lichtenberg, U., Jensen, L.J., Brunak, S. and Bork, P.
Science 307 (5710): 724-727. 4 February 2005

Endogenous MHC class II processing of a viral nuclear antigen after autophagy.
Paludan, C., Schmid, D., Landthaler, M., Vockerodt, M., Kube, D., Tuschl, T. and Muenz, C.
Science 307 (5709): 593-596. 28 January 2005

Comparative metagenomics of microbial communities.
Tringe, S.G., von Mering, C., Kobayashi, A., Salamov, A.A., Chen, K., Chang, H.W., Podar, M., Short, J.M., Mathur, E.J., Detter, J.C., Bork, P., Hugenholtz, P. and Rubin, E.M.
Science 308 : 554-557. 1 January 2005

2004

The p75 NGF receptor exposed.
Zampieri, N. and Chao, M.V.
Science 304 (5672): 833-834. 7 May 2004

Axonal neuregulin-1 regulates myelin sheath thickness.
Michailov, G.V., Sereda, M.W., Brinkmann, B.G., Fischer, T.M., Haug, B., Birchmeier, C., Role, L., Lai, C., Schwab, M.H. and Nave, K.A.
Science 304 (5671): 700-703. 30 April 2004

Structure-based assembly of protein complexes in yeast.
Aloy, P., Boettcher, B., Ceulemans, H., Leutwein, C., Mellwig, C., Fischer, S., Gavin, A.C., Bork, P., Superti-Furga, G., Serrano, L. and Russell, R.B.
Science 303 (5666): 2026-2029. 26 March 2004

Varshavsky's contributions.
Baumeister, W., Bachmair, A., Chau, V., Cohen, R., Coffino, P., DeMartino, G., Deshaies, R., Dohmen, J., Emr, S., Finley, D., Hampton, R., Hill, C., Hochstrasser, M., Huber, R., Jackson, P., Jentsch, S., Johnson, E., Kwon, Y.T., Pagano, M., Pickart, C., Rechsteiner, M., Scheffner, M., Sommer, T., Tansey, W., Tyers, M., Vierstra, R., Weissman, A., Wilkinson, K.D. and Wolf, D.
Science 306 (5700): 1290-1292. 1 January 2004

A SNP map of the rat genome generated from cDNA sequences.
Zimdahl, H., Nyakatura, G., Brandt, P., Schulz, H., Hummel, O., Fartmann, B., Brett, D., Droege, M., Monti, J., Lee, Y.A., Sun, Y.Y., Zhao, S.Y., Winter, E.E., Ponting, C.P., Chen, Y., Kasprzyk, A., Birney, E., Ganten, D. and Hubner, N.
Science 303 (5659): 807-807. 1 January 2004

2003

Neuroscience - Microglia: The enemy within?
Kempermann, G. and Neumann, H.
Science 302 (5651): 1689-1690. 5 December 2003

Chromosomal instability and tumors promoted by DNA hypomethylation.
Eden, A., Gaudet, F., Waghmare, A. and Jaenisch, R.
Science 300 (5618): 455-455. 18 April 2003

Induction of tumors in mice by genomic hypomethylation.
Gaudet, F., Hodgson, J.G., Eden, A., Jackson-Grusby, L., Dausman, J., Gray, J.W., Leonhardt, H. and Jaenisch, R.
Science 300 (5618): 489-492. 18 April 2003

LRP: role in vascular wall integrity and protection from atherosclerosis.
Boucher, P., Gotthardt, M., Li, W.P., Anderson, R.G. and Herz, J.
Science 300 : 329-332. 11 April 2003

Synthesis of serotonin by a second tryptophan hydroxylase isoform.
Walther, D.J., Peter, J.U., Bashammakh, S., Hoertnagl, H., Voits, M., Fink, H. and Bader, M.
Science 299 (5603): 76-76. 3 January 2003

2002

The genome sequence of the malaria mosquito Anopheles gambiae.
Holt, R.A., Subramanian, G.M., Halpern, A., Sutton, G.G., Charlab, R., Nusskern, D.R., Wincker, P., Clark, A.G., Ribeiro, J.M.C., Wides, R., Salzberg, S.L., Loftus, B., Yandell, M., Majoros, W.H., Rusch, D.B., Lai, Z.W., Kraft, C.L., Abril, J.F., Anthouard, V., Arensburger, P., Atkinson, P.W., Baden, H., de Berardinis, V., Baldwin, D., Benes, V., Biedler, J., Blass, C., Bolanos, R., Boscus, D., Barnstead, M., Cai, S., Center, A., Chatuverdi, K., Christophides, G.K., Chrystal, M.A., Clamp, M., Cravchik, A., Curwen, V., Dana, A., Delcher, A., Dew, I., Evans, C.A., Flanigan, M., Grundschober-Freimoser, A., Friedli, L., Gu, Z.P., Guan, P., Guigo, R., Hillenmeyer, M.E., Hladun, S.L., Hogan, J.R., Hong, Y.S., Hoover, J., Jaillon, O., Ke, Z.X., Kodira, C., Kokoza, E., Koutsos, A., Letunic, I., Levitsky, A., Liang, Y., Lin, J.J., Lobo, N.F., Lopez, J.R., Malek, J.A., McIntosh, T.C., Meister, S., Miller, J., Mobarry, C., Mongin, E., Murphy, S.D., O'Brochta, D.A., Pfannkoch, C., Qi, R., Regier, M.A., Remington, K., Shao, H.G., Sharakhova, M.V., Sitter, C.D., Shetty, J., Smith, T.J., Strong, R., Sun, J.T., Thomasova, D., Ton, L.Q., Topalis, P., Tu, Z.J., Unger, M.F., Walenz, B., Wang, A.H., Wang, J., Wang, M., Wang, X.L., Woodford, K.J., Wortman, J.R., Wu, M., Yao, A., Zdobnov, E.M., Zhang, H.Y., Zhao, Q., Zhao, S.Y., Zhu, S.P.C., Zhimulev, I., Coluzzi, M., della Torre, A., Roth, C.W., Louis, C., Kalush, F., Mural, R.J., Myers, E.W., Adams, M.D., Smith, H.O., Broder, S., Gardner, M.J., Fraser, C.M., Birney, E., Bork, P., Brey, P.T., Venter, J.C., Weissenbach, J., Kafatos, F.C., Collins, F.H. and Hoffman, S.L.
Science 298 (5591): 129-149. 4 October 2002

Comparative genome and proteome analysis of Anopheles gambiae and Drosophila melanogaster.
Zdobnov, E.M., von Mering, C., Letunic, I., Torrents, D., Suyama, M., Copley, R.R., Christophides, G.K., Thomasova, D., Holt, R.A., Subramanian, G.M., Mueller, H.M., Dimopoulos, G., Law, J.H., Wells, M.A., Birney, E., Charlab, R., Halpern, A.L., Kokoza, E., Kraft, C.L., Lai, Z., Lewis, S., Louis, C., Barillas-Mury, C., Nusskern, D., Rubin, G.M., Salzberg, S.L., Sutton, G.G., Topalis, P., Wides, R., Wincker, P., Yandell, M., Collins, F.H., Ribeiro, J., Gelbart, W.M., Kafatos, F.C. and Bork, P.
Science 298 (5591): 149-159. 4 October 2002

Worldwide scientific publishing activity.
Perez-Iratxeta, C. and Andrade, M.A.
Science 297 (5581): 519-519. 26 July 2002

Embryonic stem cells - The debate in Germany.
Reich, J.G.
Science 296 (5566): 265-265. 12 April 2002

Role of a ubiquitin-like modification in polarized morphogenesis.
Dittmar, G.A.G., Wilkinson, C.R.M., Jedrzejewski, P.T. and Finley, D.
Science 295 : 2442-2446. 29 March 2002

Mediation of hippocampal mossy fiber long-term potentiation by presynaptic Ih channels.
Mellor, J., Nicoll, R.A. and Schmitz, D.
Science 295 (5552): 143-147. 4 January 2002

Immunity-related genes and gene families in Anopheles gambiae.
Christophides, G.K., Zdobnov, E., Barillas-Mury, C., Birney, E., Blandin, S., Blass, C., Brey, P.T., Collins, F.H., Danielli, A., Dimopoulos, G., Hetru, C., Hoa, N., Hoffmann, J.A., Kanzok, S.M., Letunic, I., Levashina, E.A., Loukeris, T.G., Lycett, G., Meister, S., Michel, K., Mueller, H.M., Osta, M.A., Paskewitz, S.M., Reichhart, J.M., Rzhetsky, A., Troxler, L., Vernick, K.D., Vlachou, D., Volz, J., von Mering, C., Xu, J.N., Zheng, L.B., Bork, P. and Kafatos, F.C.
Science 298 : 159-165. 1 January 2002

2001

CNS synaptogenesis promoted by glia-derived cholesterol.
Mauch, D.H., Naegler, K., Schumacher, S., Goeritz, C., Mueller, E.C., Otto, A. and Pfrieger, F.W.
Science 294 (5545): 1354-1357. 9 November 2001

Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice.
Drab, M., Verkade, P., Elger, M., Kasper, M., Lohn, M., Lauterbach, B., Menne, J., Lindschau, C., Mende, F., Luft, F.C., Schedl, A., Haller, H. and Kurzchalia, T.V.
Science 293 (5539): 2449-2452. 28 September 2001

Presynaptic kainate receptor mediation of frequency facilitation at hippocampal mossy fiber synapses.
Schmitz, D., Mellor, J. and Nicoll, R.A.
Science 291 (5510): 1972-1976. 9 March 2001

Sequence interpretation - Functional annotation of mouse genome sequences.
Nadeau, J.H., Balling, R., Barsh, G., Beier, D., Brown, S.D.M., Bucan, M., Camper, S., Carlson, G., Copeland, N., Eppig, J., Fletcher, C., Frankel, W.N., Ganten, D., Goldowitz, D., Goodnow, C., Guenet, J.L., Hicks, G., de Angelis, M.H., Jackson, I., Jacob, H.J., Jenkins, N., Johnson, D., Justice, M., Kay, S., Kingsley, D., Lehrach, H., Magnuson, T., Meisler, M., Poustka, A.M., Rinchik, E.M., Rossant, J., Russell, L.B., Schimenti, J., Shiroishi, T., Skarnes, W.C., Soriano, P., Stanford, W., Takahashi, J.S., Wurst, W. and Zimmer, A.
Science 291 : 1251-1255. 1 January 2001

Cooperation and competition in the evolution of ATP-producing pathways.
Pfeiffer, T., Schuster, S. and Bonhoeffer, S.
Science 292 : 504-507. 1 January 2001

1999

Lateral gene transfer, genome surveys, and the phylogeny of prokaryotes.
Huynen, M.A., Snel, B. and Bork, P.
Science 286 (5444): 1443a. 19 November 1999

View from the east.
Reich, J.G.
Science 286 (5442): 1087-1087. 5 November 1999

1998

Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta.
Behrens, J., Jerchow, B.A., Wuertele, M., Grimm, J., Asbrand, C., Wirtz, R., Kuehl, M., Wedlich, D. and Birchmeier, W.
Science 280 (5363): 596-599. 24 April 1998

A potassium channel mutation in neonatal human epilepsy.
Biervert, C., Schroeder, B.C., Kubisch, C., Berkovic, S.F., Propping, P., Jentsch, T.J. and Steinlein, O.K.
Science 279 (5349): 403-406. 16 January 1998

1997

Role of Cue1p in ubiquitination and degradition at the ER surface.
Biederer, T., Volkwein, C. and Sommer, T.
Science 278 (5344): 1806-1809. 5 December 1997

Gene families: the taxonomy of protein paralogs and chimeras.
Henikoff, S., Greene, E.A., Pietrokovski, S., Bork, P., Attwood, T.K. and Hood, L.
Science 278 (5338): 609-614. 24 October 1997

Synaptic efficacy enhanced by glial cells in vitro.
Pfrieger, F.W. and Barres, B.A.
Science 277 (5332): 1684-1687. 12 September 1997

Genome maps 8. Building gene families. Wall chart.
Greene, E.A., Pietrokovski, S., Henikoff, S., Bork, P., Attwood, T.K., Hood, L. and Bairoch, A.
Science 278 : 615-626. 1 January 1997

1996

Neurogenic amplification of immune complex inflammation.
Bozic, C.R., Lu, B., Höpken, U.E., Gerard, C. and Gerard, N.P.
Science 273 (5282): 1722-1725. 20 September 1996

Sperm-egg binding protein or proto-oncogene?
Bork, P.
Science 271 (5254): 1431-1432. 1 January 1996

1995

Separation of origin recognition complex functions by cross-species complementation.
Ehrenhofer-Murray, A.E., Gossen, M., Pak, D.T., Botchan, M.R. and Rine, J.
Science 270 (5242): 1671-1674. 8 December 1995

A Drosophila homolog of the yeast origin recognition complex.
Gossen, M., Pak, D.T., Hansen, S.K., Acharya, J.K. and Botchan, M.R.
Science 270 (5242): 1674-1677. 8 December 1995

Inducible gene targeting in mice.
Kühn, R., Schwenk, F., Aguet, M. and Rajewsky, K.
Science 269 (5229): 1427-1429. 8 September 1995

Transcriptional activation by tetracyclines in mammalian cells.
Gossen, M., Freundlieb, S., Bender, G., Muller, G., Hillen, W. and Bujard, H.
Science 268 (5218): 1766-1769. 23 June 1995

1994

MHC class I expression in mice lacking the proteasome subunit LMP-7.
Fehling, H.J., Swat, W., Laplace, C., Kühn, R., Rajewsky, K., Müller, U. and von Boehmer, H.
Science 265 (5176): 1234-1237. 26 August 1994

Resistance to murine acquired immunodeficiency syndrome (MAIDS).
Morawetz, R.A., Doherty, T.M., Giese, N.A., Hartley, J.W., Müller, W., Kühn, R., Rajewsky, K., Coffman, R. and Morse, H.C.
Science 265 (5169): 264-266. 8 July 1994

Inhibition of hepatic chylomicron remnant uptake by gene transfer of a receptor antagonist.
Willnow, T.E., Sheng, Z., Ishibashi, S. and Herz, J.
Science 264 (5164): 1471-1474. 3 June 1994

Structure of the Tet repressor-tetracycline complex and regulation of antibiotic resistance.
Hinrichs, W., Kisker, C., Duevel, M., Mueller, A., Tovar, K., Hillen, W. and Saenger, W.
Science 264 (5157): 418-420. 15 April 1994

1992

Transport of proteins across the endoplasmic reticulum membrane.
Rapoport, T.A.
Science 258 (5084): 931-936. 6 November 1992

The skeletal muscle chloride channel in dominant and recessive human myotonia.
Koch, M.C., Steinmeyer, K., Lorenz, C., Ricker, K., Wolf, F., Otto, M., Zoll, B., Lehmann-Horn, F., Grzeschik, K.H. and Jentsch, T.J.
Science 257 (5071): 797-800. 7 August 1992

Calcium entry through kainate receptors and resulting potassium- channel blockade in Bergmann glial cells.
Mueller, T., Moeller, T., Berger, T., Schnitzer-Ungefug, J. and Kettenmann, H.
Science 256 (5063): 1563-1566. 12 June 1992

1991

Generation and analysis of interleukin-4 deficient mice.
Kühn, R., Rajewsky, K. and Müller, W.
Science 254 (5032): 707-710. 1 November 1991