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2018

Cell type atlas and lineage tree of a whole complex animal by single-cell transcriptomics.
Plass, M. and Solana, J. and Wolf, F.A. and Ayoub, S. and Misios, A. and Glažar, P. and Obermayer, B. and Theis, F.J. and Kocks, C. and Rajewsky, N.
Science 360 (6391): eaaq1723. 25 May 2018

Diverging roads to the heart.
Kelly, R.G. and Sperling, S.R.
Science 359 (6380): 1098-1099. 9 March 2018

2017

The Drosophila embryo at single-cell transcriptome resolution.
Karaiskos, N. and Wahle, P. and Alles, J. and Boltengagen, A. and Ayoub, S. and Kipar, C. and Kocks, C. and Rajewsky, N. and Zinzen, R.P.
Science 358 (6360): 194-199. 13 October 2017

Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function.
Piwecka, M. and Glažar, P. and Hernandez-Miranda, L.R. and Memczak, S. and Wolf, S.A. and Rybak-Wolf, A. and Filipchyk, A. and Klironomos, F. and Cerda Jara, C.A. and Fenske, P. and Trimbuch, T. and Zywitza, V. and Plass, M. and Schreyer, L. and Ayoub, S. and Kocks, C. and Kühn, R. and Rosenmund, C. and Birchmeier, C. and Rajewsky, N.
Science 357 (6357): eaam8526. 22 September 2017

Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat.
Park, T.J. and Reznick, J. and Peterson, B.L. and Blass, G. and Omerbašić, D. and Bennett, N.C. and Kuich, P.H.J.L. and Zasada, C. and Browe, B.M. and Hamann, W. and Applegate, D.T. and Radke, M.H. and Kosten, T. and Lutermann, H. and Gavaghan, V. and Eigenbrod, O. and Bégay, V. and Amoroso, V. G. and Govind, V. and Minshall, R.D. and Smith, E.S.J. and Larson, J. and Gotthardt, M. and Kempa, S. and Lewin, G.R.
Science 356 (6335): 307-311. 21 April 2017

2016

Microglia development follows a stepwise program to regulate brain homeostasis.
Matcovitch-Natan, O. and Winter, D.R. and Giladi, A. and Vargas Aguilar, S. and Spinrad, A. and Sarrazin, S. and Ben-Yehuda, H. and David, E. and Zelada González, F. and Perrin, P. and Keren-Shaul, H. and Gury, M. and Lara-Astaiso, D. and Thaiss, C.A. and Cohen, M. and Bahar Halpern, K. and Baruch, K. and Deczkowska, A. and Lorenzo-Vivas, E. and Itzkovitz, S. and Elinav, E. and Sieweke, M.H. and Schwartz, M. and Amit, I.
Science 353 (6301): aad8670. 19 August 2016

Crimea report leaves readers in the cold.
Goushcha, A. and Goloverda, G.Z. and Kotsyuba, O. and Perepichka, D.F. and Seumenicht, O. and Ladokhin, A.S.
Science 352 (6287): 780-781. 13 May 2016

Durable coexistence of donor and recipient strains after fecal microbiota transplantation.
Li, S.S. and Zhu, A. and Benes, V. and Costea, P.I. and Hercog, R. and Hildebrand, F. and Huerta-Cepas, J. and Nieuwdorp, M. and Salojaervi, J. and Voigt, A.Y. and Zeller, G. and Sunagawa, S. and de Vos, W.M. and Bork, P.
Science 352 (6285): 586-589. 29 April 2016

Single-vesicle imaging reveals different transport mechanisms between glutamatergic and GABAergic vesicles.
Farsi, Z. and Preobraschenski, J. and van den Bogaart, G. and Riedel, D. and Jahn, R. and Woehler, A.
Science 351 (6276): 981-984. 26 February 2016

Lineage-specific enhancers activate self-renewal genes in macrophages and embryonic stem cells.
Soucie, E.L. and Weng, Z. and Geirsdóttir, L. and Molawi, K. and Maurizio, J. and Fenouil, R. and Mossadegh-Keller, N. and Gimenez, G. and VanHille, L. and Beniazza, M. and Favret, J. and Berruyer, C. and Perrin, P. and Hacohen, N. and Andrau, J.C. and Ferrier, P. and Dubreuil, P. and Sidow, A. and Sieweke, M.H.
Science 351 (6274): aad5510. 12 February 2016

2015

Operon structure and cotranslational subunit association direct protein assembly in bacteria.
Shieh, Y.W. and Minguez, P. and Bork, P. and Auburger, J.J. and Guilbride, D.L. and Kramer, G. and Bukau, B.
Science 350 (6261): 678-680. 6 November 2015

Transcriptional control of tissue formation throughout root development.
Moreno-Risueno, M.A. and Sozzani, R. and Yardımcı, G.G. and Petricka, J.J. and Vernoux, T. and Blilou, I. and Alonso, J. and Winter, C.M. and Ohler, U. and Scheres, B. and Benfey, P.N.
Science 350 (6259): 426-430. 23 October 2015

Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy.
Hinson, J.T. and Chopra, A. and Nafissi, N. and Polacheck, W.J. and Benson, C.C. and Swist, S. and Gorham, J. and Yang, L. and Schafer, S. and Sheng, C.C. and Haghighi, A. and Homsy, J. and Hubner, N. and Church, G. and Cook, S.A. and Linke, W.A. and Chen, C.S. and Seidman, J.G. and Seidman, C.E.
Science 349 (6251): 982-986. 28 August 2015

Patterns and ecological drivers of ocean viral communities.
Brum, J.R. and Ignacio-Espinoza, J.C. and Roux, S. and Doulcier, G. and Acinas, S.G. and Alberti, A. and Chaffron, S. and Cruaud, C. and de Vargas, C. and Gasol, J.M. and Gorsky, G. and Gregory, A.C. and Guidi, L. and Hingamp, P. and Iudicone, D. and Not, F. and Ogata, H. and Pesant, S. and Poulos, B.T. and Schwenck, S.M. and Speich, S. and Dimier, C. and Kandels-Lewis, S. and Picheral, M. and Searson, S. and Bork, P. and Bowler, C. and Sunagawa, S. and Wincker, P. and Karsenti, E. and Sullivan, M.B.
Science 348 (6237): 1261498. 22 May 2015

Determinants of community structure in the global plankton interactome.
Lima-Mendez, G. and Faust, K. and Henry, N. and Decelle, J. and Colin, S. and Carcillo, F. and Chaffron, S. and Ignacio-Espinosa, J.C. and Roux, S. and Vincent, F. and Bittner, L. and Darzi, Y. and Wang, J. and Audic, S. and Berline, L. and Bontempi, G. and Cabello, A.M. and Coppola, L. and Cornejo-Castillo, F.M. and d' Ovidio, F. and De Meester, L. and Ferrera, I. and Garet-Delmas, M.J. and Guidi, L. and Lara, E. and Pesant, S. and Royo-Llonch, M. and Salazar, G. and Sanchez, P. and Sebastian, M. and Souffreau, C. and Dimier, C. and Picheral, M. and Searson, S. and Kandels-Lewis, S. and Gorsky, G. and Not, F. and Ogata, H. and Speich, S. and Stemmann, L. and Weissenbach, J. and Wincker, P. and Acinas, S.G. and Sunagawa, S. and Bork, P. and Sullivan, M.B. and Karsenti, E. and Bowler, C. and de Vargas, C. and Raes, J.
Science 348 (6237): 1262073. 22 May 2015

Structure and function of the global ocean microbiome.
Sunagawa, S. and Coelho, L.P. and Chaffron, S. and Kultima, J.R. and Labadie, K. and Salazar, G. and Djahanschiri, B. and Zeller, G. and Mende, D.R. and Alberti, A. and Cornejo-Castillo, F.M. and Costea, P.I. and Cruaud, C. and d'Ovidio, F. and Engelen, S. and Ferrera, I. and Gasol, J.M. and Guidi, L. and Hildebrand, F. and Kokoszka, F. and Lepoivre, C. and Lima-Mendez, G. and Poulain, J. and Poulos, B.T. and Royo-Llonch, M. and Sarmento, H. and Vieira-Silva, S. and Dimier, C. and Picheral, M. and Searson, S. and Kandels-Lewis, S. and Bowler, C. and de Vargas, C. and Gorsky, G. and Grimsley, N. and Hingamp, P. and Iudicone, D. and Jaillon, O. and Not, F. and Ogata, H. and Pesant, S. and Speich, S. and Stemmann, L. and Sullivan, M.B. and Weissenbach, J. and Wincker, P. and Karsenti, E. and Raes, J. and Acinas, S.G. and Bork, P.
Science 348 (6237): 1261359. 22 May 2015

Environmental characteristics of Agulhas rings affect interocean plankton transport.
Villar, E. and Farrant, G.K. and Follows, M. and Garczarek, L. and Speich, S. and Audic, S. and Bittner, L. and Blanke, B. and Brum, J.R. and Brunet, C. and Casotti, R. and Chase, A. and Dolan, J.R. and d'Ortenzio, F. and Gattuso, J.P. and Grima, N. and Guidi, L. and Hill, C.N. and Jahn, O. and Jamet, J.L. and Le Goff, H. and Lepoivre, C. and Malviya, S. and Pelletier, E. and Romagnan, J.B. and Roux, S. and Santini, S. and Scalco, E. and Schwenck, S.M. and Tanaka, A. and Testor, P. and Vannier, T. and Vincent, F. and Zingone, A. and Dimier, C. and Picheral, M. and Searson, S. and Kandels-Lewis, S. and Acinas, S.G. and Bork, P. and Boss, E. and de Vargas, C. and Gorsky, G. and Ogata, H. and Pesant, S. and Sullivan, M.B. and Sunagawa, S. and Wincker, P. and Karsenti, E. and Bowler, C. and Not, F. and Hingamp, P. and Iudicone, D.
Science 348 (6237): 1261447. 22 May 2015

Eukaryotic plankton diversity in the sunlit ocean.
de Vargas, C. and Audic, S. and Henry, N. and Decelle, J. and Mahe, F. and Logares, R. and Lara, E. and Berney, C. and Le Bescot, N. and Probert, I. and Carmichael, M. and Poulain, J. and Romac, S. and Colin, S. and Aury, J.M. and Bittner, L. and Chaffron, S. and Dunthorn, M. and Engelen, S. and Flegontova, O. and Guidi, L. and Horak, A. and Jaillon, O. and Lima-Mendez, G. and Lukes, J. and Malviya, S. and Morard, R. and Mulot, M. and Scalco, E. and Siano, R. and Vincent, F. and Zingone, A. and Dimier, C. and Picheral, M. and Searson, S. and Kandels-Lewis, S. and Acinas, S.G. and Bork, P. and Bowler, C. and Gorsky, G. and Grimsley, N. and Hingamp, P. and Iudicone, D. and Not, F. and Ogata, H. and Pesant, S. and Raes, J. and Sieracki, M.E. and Speich, S. and Stemmann, L. and Sunagawa, S. and Weissenbach, J. and Wincker, P. and Karsenti, E.
Science 348 (6237): 1261605. 22 May 2015

Dynamic profiling of the protein life cycle in response to pathogens.
Jovanovic, M. and Rooney, M.S. and Mertins, P. and Przybylski, D. and Chevrier, N. and Satija, R. and Rodriguez, E.H. and Fields, A.P. and Schwartz, S. and Raychowdhury, R. and Mumbach, M.R. and Eisenhaure, T. and Rabani, M. and Gennert, D. and Lu, D. and Delorey, T. and Weissman, J.S. and Carr, S.A. and Hacohen, N. and Regev, A.
Science 347 (6226): 1259038. 6 March 2015

Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells.
Arner, E. and Daub, C.O. and Vitting-Seerup, K. and Andersson, R. and Lilje, B. and Drabløs, F. and Lennartsson, A. and Rönnerblad, M. and Hrydziuszko, O. and Vitezic, M. and Freeman, T.C. and Alhendi, A. and Arner, P. and Axton, R. and Baillie, J.K. and Beckhouse, A. and Bodega, B. and Briggs, J. and Brombacher, F. and Davis, M. and Detmar, M. and Ehrlund, A. and Endoh, M. and Eslami, A. and Fagiolini, M. and Fairbairn, L. and Faulkner, G.J. and Ferrai, C. and Fisher, M.E. and Forrester, L. and Goldowitz, D. and Guler, R. and Ha, T. and Hara, M. and Herlyn, M. and Ikawa, T. and Kai, C. and Kawamoto, H. and Khachigian, L. and Klinken, P.S. and Kojima, S. and Koseki, H. and Klein, S. and Mejhert, N. and Miyaguchi, K. and Mizuno, Y. and Morimoto, M. and Morris, K.J. and Mummery, C. and Nakachi, Y. and Ogishima, S. and Okada-Hatakeyama, M. and Okazaki, Y. and Orlando, V. and Ovchinnikov, D. and Passier, R. and Patrikakis, M. and Pombo, A. and Qin, X.Y. and Roy, S. and Sato, H. and Savvi, S. and Saxena, A. and Schwegmann, A. and Sugiyama, D. and Swoboda, R. and Tanaka, H. and Tomoiu, A. and Winteringham, L.N. and Wolvetang, E. and Yanagi-Mizuochi, C. and Yoneda, M. and Zabierowski, S. and Zhang, P. and Abugessaisa, I. and Bertin, N. and Diehl, A.D. and Fukuda, S. and Furuno, M. and Harshbarger, J. and Hasegawa, A. and Hori, F. and Ishikawa-Kato, S. and Ishizu, Y. and Itoh, M. and Kawashima, T. and Kojima, M. and Kondo, N. and Lizio, M. and Meehan, T.F. and Mungall, C.J. and Murata, M. and Nishiyori-Sueki, H. and Sahin, S. and Sato-Nagao, S. and Severin, J. and de Hoon, M.J. and Kawai, J. and Kasukawa, T. and Lassmann, T. and Suzuki, H. and Kawaji, H. and Summers, K.M. and Wells, C. and Hume, D.A. and Forrest, A.R.R. and Sandelin, A. and Carninci, P. and Hayashizaki, Y.
Science 347 (6225): 1010-1014. 27 February 2015

2014

Parasympathetic neurons originate from nerve-associated peripheral glial progenitors.
Dyachuk, V. and Furlan, A. and Shahidi, M.K. and Giovenco, M. and Kaukua, N. and Konstantinidou, C. and Pachnis, V. and Memic, F. and Marklund, U. and Müller, T. and Birchmeier, C. and Fried, K. and Ernfors, P. and Adameyko, I.
Science 345 (6192): 82-87. 4 July 2014

Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC.
Voss, F.K. and Ullrich, F. and Muench, J. and Lazarow, K. and Lutter, D. and Mah, N. and Andrade-Navarro, M.A. and von Kries, J.P. and Stauber, T. and Jentsch, T.J.
Science 344 (6184): 634-638. 9 May 2014

2013

Beyond stem cells: self-renewal of differentiated macrophages.
Sieweke, M.H. and Allen, J.E.
Science 342 (6161): 1242974. 22 November 2013

Natural selection and pain meet at a sodium channel.
Lewin, G.R.
Science 342 (6157): 428-429. 25 October 2013

NextGen speaks.
Lacadie, S.A.
Science 340 (6128): 29. April 2013

Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching.
Di Virgilio, M. and Callen, E. and Yamane, A. and Zhang, W. and Jankovic, M. and Gitlin, A.D. and Feldhahn, N. and Resch, W. and Oliveira, T.Y. and Chait, B.T. and Nussenzweig, A. and Casellas, R. and Robbiani, D.F. and Nussenzweig, M.C.
Science 339 (6120): 711-715. 8 February 2013

2012

Segregation of axonal and somatic activity during fast network oscillations.
Dugladze, T. and Schmitz, D. and Whittington, M.A. and Vida, I. and Gloveli, T.
Science 336 (6087): 1458-1461. 15 June 2012

p53 dynamics control cell fate.
Purvis, J.E. and Karhohs, K.W. and Mock, C. and Batchelor, E. and Loewer, A. and Lahav, G.
Science 336 (6087): 1440-1444. 15 June 2012

The transcription factor c-Maf controls touch receptor development and function.
Wende, H. and Lechner, S.G. and Cheret, C. and Bourane, S. and Kolanczyk, M.E. and Pattyn, A. and Reuter, K. and Munier, F.L. and Carroll, P. and Lewin, G.R. and Birchmeier, C.
Science 335 (6074): 1373-1376. 16 March 2012

2011

RIM-binding protein, a central part of the active zone, is essential for neurotransmitter release.
Liu, K.S.Y. and Siebert, M. and Mertel, S. and Knoche, E. and Wegener, S. and Wichmann, C. and Matkovic, T. and Muhammad, K. and Depner, H. and Mettke, C. and Bueckers, J. and Hell, S.W. and Mueller, M. and Davis, G.W. and Schmitz, D. and Sigrist, S.J.
Science 334 (6062): 1565-1659. 16 December 2011

The molecular basis of acid insensitivity in the African naked mole-rat.
Smith, E.S.J. and Omerbasic, D. and Lechner, S.G. and Anirudhan, G. and Lapatsina, L. and Lewin, G.R.
Science 334 (6062): 1557-1560. 16 December 2011

Direct conversion of C. elegans germ cells into specific neuron types.
Tursun, B. and Patel, T. and Kratsios, P. and Hobert, O.
Science 331 (6015): 304-308. 21 January 2011

2010

Integrative analysis of the caenorhabditis elegans genome by the modENCODE project.
Gerstein, M.B. and Lu, Z.J. and Van Nostrand, E.L. and Cheng, C. and Arshinoff, B.I. and Liu, T. and Yip, K.Y. and Robilotto, R. and Rechtsteiner, A. and Ikegami, K. and Alves, P. and Chateigner, A. and Perry, M. and Morris, M. and Auerbach, R.K. and Feng, X. and Leng, J. and Vielle, A. and Niu, W. and Rhrissorrakrai, K. and Agarwal, A. and Alexander, R.P. and Barber, G. and Brdlik, C.M. and Brennan, J. and Brouillet, J.J. and Carr, A. and Cheung, M.S. and Clawson, H. and Contrino, S. and Dannenberg, L.O. and Dernburg, A.F. and Desai, A. and Dick, L. and Dose, A.C. and Du, J. and Egelhofer, T. and Ercan, S. and Euskirchen, G. and Ewing, B. and Feingold, E.A. and Gassmann, R. and Good, P.J. and Green, P. and Gullier, F. and Gutwein, M. and Guyer, M.S. and Habegger, L. and Han, T. and Henikoff, J.G. and Henz, S.R. and Hinrichs, A. and Holster, H. and Hyman, T. and Iniguez, A.L. and Janette, J. and Jensen, M. and Kato, M. and Kent, W.J. and Kephart, E. and Khivansara, V. and Khurana, E. and Kim, J.K. and Kolasinska-Zwierz, P. and Lai, E.C. and Latorre, I. and Leahey, A. and Lewis, S. and Lloyd, P. and Lochovsky, L. and Lowdon, R.F. and Lubling, Y. and Lyne, R. and Maccoss, M. and Mackowiak, S.D. and Mangone, M. and McKay, S. and Mecenas, D. and Merrihew, G. and Miller, D.M. and Muroyama, A. and Murray, J.I. and Ooi, S.L. and Pham, H. and Phippen, T. and Preston, E.A. and Rajewsky, N. and Raetsch, G. and Rosenbaum, H. and Rozowsky, J. and Rutherford, K. and Ruzanov, P. and Sarov, M. and Sasidharan, R. and Sboner, A. and Scheid, P. and Segal, E. and Shin, H. and Shou, C. and Slack, F.J. and Slightam, C. and Smith, R. and Spencer, W.C. and Stinson, E.O. and Taing, S. and Takasaki, T. and Vafeados, D. and Voronina, K. and Wang, G. and Washington, N.L. and Whittle, C.M. and Wu, B. and Yan, K.K. and Zeller, G. and Zha, Z. and Zhong, M. and Zhou, X. and Ahringer, J. and Strome, S. and Gunsalus, K.C. and Micklem, G. and Liu, X.S. and Reinke, V. and Kim, S.K. and Hillier, L.W. and Henikoff, S. and Piano, F. and Snyder, M. and Stein, L. and Lieb, J.D. and Waterston, R.H.
Science 330 (6012): 1775-1787. 24 December 2010

The Landscape of C. elegans 3'UTRs.
Mangone, M. and Manoharan, A.P. and Thierry-Mieg, D. and Thierry-Mieg, J. and Han, T. and Mackowiak, S. and Mis, E. and Zegar, C. and Gutwein, M.R. and Khivansara, V. and Attie, O. and Chen, K. and Salehi-Ashtiani, K. and Vidal, M. and Harkins, T.T. and Bouffard, P. and Suzuki, Y. and Sugano, S. and Kohara, Y. and Rajewsky, N. and Piano, F. and Gunsalus, K.C. and Kim, J.K.
Science 329 (5990): 432-435. 23 July 2010

Endosomal chloride-proton exchange rather than chloride conductance is crucial for renal endocytosis.
Novarino, G. and Weinert, S. and Rickheit, G. and Jentsch, T.J.
Science 328 (5984): 1398-1401. 11 June 2010

Lysosomal pathology and osteopetrosis upon loss of H+-driven lysosomal Cl- accumulation.
Weinert, S. and Jabs, S. and Supanchart, C. and Schweizer, M. and Gimber, N. and Richter, M. and Rademann, J. and Stauber, T. and Kornak, U. and Jentsch, T.J.
Science 328 (5984): 1401-1403. 11 June 2010

Altered histone acetylation is associated with age-dependent memory impairment in mice.
Peleg, S. and Sananbenesi, F. and Zovoilis, A. and Burkhardt, S. and Bahari-Javan, S. and Agis-Balboa, R.C. and Cota, P. and Wittnam, J.L. and Gogol-Doering, A. and Opitz, L. and Salinas-Riester, G. and Dettenhofer, M. and Kang, H. and Farinelli, L. and Chen, W. and Fischer, A.
Science 328 (5979): 753-756. 7 May 2010

2009

Transcriptome complexity in a genome-reduced bacterium.
Gueell, M. and van Noort, V. and Yus, E. and Chen, W.H. and Leigh-Bell, J. and Michalodimitrakis, K. and Yamada, T. and Arumugam, M. and Doerks, T. and Kuehner, S. and Rode, M. and Suyama, M. and Schmidt, S. and Gavin, A.C. and Bork, P. and Serrano, L.
Science 326 (5957): 1268-1271. 27 November 2009

Proteome organization in a genome-reduced bacterium.
Kuehner, S. and van Noort, V. and Betts, M.J. and Leo-Macias, A. and Batisse, C. and Rode, M. and Yamada, T. and Maier, T. and Bader, S. and Beltran-Alvarez, P. and Castano-Diez, D. and Chen, W.H. and Devos, D. and Gueell, M. and Norambuena, T. and Racke, I. and Rybin, V. and Schmidt, A. and Yus, E. and Aebersold, R. and Herrmann, R. and Boettcher, B. and Frangakis, A.S. and Russell, R.B. and Serrano, L. and Bork, P. and Gavin, A.C.
Science 326 (5957): 1235-1240. 27 November 2009

Impact of genome reduction on bacterial metabolism and its regulation.
Yus, E. and Maier, T. and Michalodimitrakis, K. and van Noort, V. and Yamada, T. and Chen, W.H. and Wodke, J.A. and Gueell, M. and Martinez, S. and Bourgeois, R. and Kuehner, S. and Raineri, E. and Letunic, I. and Kalinina, O.V. and Rode, M. and Herrmann, R. and Gutierrez-Gallego, R. and Russell, R.B. and Gavin, A.C. and Bork, P. and Serrano, L.
Science 326 (5957): 1263-1268. 27 November 2009

Ligand-dependent equilibrium fluctuations of single calmodulin molecules.
Junker, J.P. and Ziegler, F. and Rief, M.
Science 323 (5914): 633-637. 30 January 2009

2008

Biochemistry. Not comparable, but complementary.
Jensen, L.J. and Bork, P.
Science 322 (5898): 56-57. 3 October 2008

Drug target identification using side-effect similarity.
Campillos, M. and Kuhn, M. and Gavin, A.C. and Jensen, L.J. and Bork, P.
Science 321 (5886): 263-266. 11 July 2008

Subdiffraction multicolor imaging of the nuclear periphery with 3D structured illumination microscopy.
Schermelleh, L. and Carlton, P.M. and Haase, S. and Shao, L. and Winoto, L. and Kner, P. and Burke, B. and Cardoso, M.C. and Agard, D.A. and Gustafsson, M.G. and Leonhardt, H. and Sedat, J.W.
Science 320 (5881): 1332-1336. 6 June 2008

Neuroscience : Rules of plasticity.
Brecht, M. and Schmitz, D.
Science 319 (5859): 39-40. 4 January 2008

2007

Genome-wide experimental determination of barriers to horizontal gene transfer.
Sorek, R. and Zhu, Y. and Creevey, C.J. and Francino, M.P. and Bork, P. and Rubin, E.M.
Science 318 (5855): 1449-1452. 30 November 2007

A high-resolution root spatiotemporal map reveals dominant expression patterns.
Brady, S.M. and Orlando, D.A. and Lee, J.Y. and Wang, J.Y. and Koch, J. and Dinneny, J.R. and Mace, D. and Ohler, U. and Benfey, P.N.
Science 318 (5851): 801-806. 2 November 2007

Regulation of the germinal center response by microRNA-155.
Thai, T.H. and Calado, D.P. and Casola, S. and Ansel, K.M. and Xiao, C. and Xue, Y. and Murphy, A. and Frendewey, D. and Valenzuela, D. and Kutok, J.L. and Schmidt-Supprian, M. and Rajewsky, N. and Yancopoulos, G. and Rao, A. and Rajewsky, K.
Science 316 (5824): 604-608. 27 April 2007

Quantitative phylogenetic assessment of microbial communities in diverse environments.
von Mering, C. and Hugenholtz, P. and Raes, J. and Tringe, S.G. and Doerks, T. and Jensen, L.J. and Ward, N. and Bork, P.
Science 315 (5815): 1126-1130. 23 February 2007

2006

Control of peripheral nerve myelination by the β-secretase BACE1.
Willem, M. and Garratt, A.N. and Novak, B. and Citron, M. and Kaufmann, S. and Rittger, A. and Destrooper, B. and Saftig, P. and Birchmeier, C. and Haass, C.
Science 314 (5799): 664-666. 27 October 2006

Platelet-derived serotonin mediates liver regeneration.
Lesurtel, M. and Graf, R. and Aleil, B. and Walther, D.J. and Tian, Y. and Jochum, W. and Gachet, C. and Bader, M. and Clavien, P.A.
Science 312 (5770): 104-107. 7 April 2006

Toward automatic reconstruction of a highly resolved tree of life.
Ciccarelli, F.D. and Doerks, T. and von Mehring, C. and Creevey, C.J. and Snel, B. and Bork, P.
Science 311 (5765): 1283-1287. 3 March 2006

The cellular basis of a corollary discharge.
Poulet, J.F.A. and Hedwig, B.
Science 311 (5760): 518-522. 27 January 2006

2005

Vertebrate-type intron-rich genes in the marine annelid Platynereis dumerilii.
Raible, F. and Tessmar-Raible, K. and Osoegawa, K. and Wincker, P. and Jubin, C. and Balavoine, G. and Ferrier, D. and Benes, V. and de Jong, P. and Weissenbach, J. and Bork, P. and Arendt, D.
Science 310 : 1325-1326. 25 November 2005

The transcriptional landscape of the mammalian genome.
Carninci, P. and Kasukawa, T. and Katayama, S. and Gough, J. and Frith, M.C. and Maeda, N. and Oyama, R. and Ravasi, T. and Lenhard, B. and Wells, C. and Kodzius, R. and Shimokawa, K. and Bajic, V.B. and Brenner, S.E. and Batalov, S. and Forrest, A.R.R. and Zavolan, M. and Davis, M.J. and Wilming, L.G. and Aidinis, V. and Allen, J.E. and Ambesi-Impiombato, A. and Apweiler, R. and Aturaliya, R.N. and Bailey, T.L. and Bansal, M. and Baxter, L. and Beisel, K.W. and Bersano, T. and Bono, H. and Chalk, A.M. and Chiu, K.P. and Choudhary, V. and Christoffels, A. and Clutterbuck, D.R. and Crowe, M.L. and Dalla, E. and Dalrymple, B.P. and de Bono, B. and Della Gatta, G. and di Bernardo, D. and Down, T. and Engstrom, P. and Fagiolini, M. and Faulkner, G. and Fletcher, C.F. and Fukushima, T. and Furuno, M. and Futaki, S. and Gariboldi, M. and Georgii-Hemming, P. and Gingeras, G.R. and Gojobori, T. and Green, R.E. and Gustincich, S. and Harbers, M. and Hayashi, Y. and Hensch, T.K. and Hirokawa, N. and Hill, D. and Huminiecki, L. and Iacono, I. and Ikeo, K. and Iwama, A. and Ishikawa, T. and Jakt, M. and Kanapin, A. and Katoh, M. and Kawasawa, Y. and Kelso, J. and Kitamura, H. and Kitano, H. and Kollias, G. and Krishnan, S.P.T. and Kruger, A. and Kummerfeld, S.K. and Kurochkin, I.V. and Lareau, L.F. and Lazarevic, D. and Lipovich, L. and Liu, J. and Liuni, S. and McWilliam, S. and Madan Babu, M. and Madera, M. and Marchionni, L. and Matsuda, H. and Matsuzawa, S. and Miki, H. and Mignone, F. and Miyake, S. and Morris, K. and Mottagui-Tabar, S. and Mulder, N. and Nakano, N. and Nakauchi, H. and Ng, P. and Nilsson, R. and Nishiguchi, S. and Nishikawa, S. and Nori, F. and Ohara, O. and Okazaki, Y. and Orlando, V. and Pang, K.C. and Pavan, W.J. and Pavesi, G. and Pesole, G. and Petrovsky, N. and Piazza, S. and Reed, J. and Reid, J.F. and Ring, B.Z. and Ringwald, M. and Rost, B. and Ruan, Y. and Salzberg, S.L. and Sandelin, A. and Schneider, C. and Schönbach, C. and Sekiguchi, S. and Semple, C.A.M. and Seno, S. and Sessa, L. and Sheng, Y. and Shibata, Y. and Shimada, H. and Shimada, K. and Silva, D. and Sinclair, B. and Sperling, S. and Stupka, E. and Sugiura, S. and Sultana, R. and Takenaka, Y. and Taki, K. and Tammoja, K. and Tan, S.L. and Tang, S. and Taylor, M.S. and Tegner, J. and Teichmann, S.A. and Ueda, H.R. and van Nimwegen, E. and Verardo, R. and Wei, C.L. and Yagi, K. and Yamanishi, H. and Zabarovsky, E. and Zhu, S. and Zimmer, A. and Hide, W. and Bult, C. and Grimmond, S.M. and Teasdale, R.D. and Liu, E.T. and Brusic, V. and Quackenbush, J. and Wahlestedt, C. and Mattick, J.S. and Hume, D.A. and Kai, C. and Sasaki, D. and Tomaru, Y. and Fukuda, S. and Kanamori-Katayama, M. and Suzuki, M. and Aoki, J. and Arakawa, T. and Iida, J. and Imamura, K. and Itoh, M. and Kato, T. and Kawaji, H. and Kawagashira, N. and Kawashima, T. and Kojima, M. and Kondo, S. and Konno, H. and Nakano, K. and Ninomiya, N. and Nishio, T. and Okada, M. and Plessy, C. and Shibata, K. and Shiraki, T. and Suzuki, S. and Tagami, M. and Waki, K. and Watahiki, A. and Okamura-Oho, Y. and Suzuki, H. and Kawai, J. and Hayashizaki, Y.
Science 309 (5740): 1559-1563. 2 September 2005

An acylation cycle regulates localization and activity of palmitoylated Ras isoforms.
Rocks, O. and Peyker, A. and Kahms, M. and Verveer, P.J. and Koerner, C. and Lumbierres, M. and Kuhlmann, J. and Waldmann, H. and Wittinghofer, A. and Bastiaens, P.I.
Science 307 (5716): 1746-1752. 18 March 2005

Dynamic complex formation during the yeast cell cycle.
de Lichtenberg, U. and Jensen, L.J. and Brunak, S. and Bork, P.
Science 307 (5710): 724-727. 4 February 2005

Endogenous MHC class II processing of a viral nuclear antigen after autophagy.
Paludan, C. and Schmid, D. and Landthaler, M. and Vockerodt, M. and Kube, D. and Tuschl, T. and Muenz, C.
Science 307 (5709): 593-596. 28 January 2005

Comparative metagenomics of microbial communities.
Tringe, S.G. and von Mering, C. and Kobayashi, A. and Salamov, A.A. and Chen, K. and Chang, H.W. and Podar, M. and Short, J.M. and Mathur, E.J. and Detter, J.C. and Bork, P. and Hugenholtz, P. and Rubin, E.M.
Science 308 : 554-557. 1 January 2005

2004

The p75 NGF receptor exposed.
Zampieri, N. and Chao, M.V.
Science 304 (5672): 833-834. 7 May 2004

Axonal neuregulin-1 regulates myelin sheath thickness.
Michailov, G.V. and Sereda, M.W. and Brinkmann, B.G. and Fischer, T.M. and Haug, B. and Birchmeier, C. and Role, L. and Lai, C. and Schwab, M.H. and Nave, K.A.
Science 304 (5671): 700-703. 30 April 2004

Structure-based assembly of protein complexes in yeast.
Aloy, P. and Boettcher, B. and Ceulemans, H. and Leutwein, C. and Mellwig, C. and Fischer, S. and Gavin, A.C. and Bork, P. and Superti-Furga, G. and Serrano, L. and Russell, R.B.
Science 303 (5666): 2026-2029. 26 March 2004

Varshavsky's contributions.
Baumeister, W. and Bachmair, A. and Chau, V. and Cohen, R. and Coffino, P. and DeMartino, G. and Deshaies, R. and Dohmen, J. and Emr, S. and Finley, D. and Hampton, R. and Hill, C. and Hochstrasser, M. and Huber, R. and Jackson, P. and Jentsch, S. and Johnson, E. and Kwon, Y.T. and Pagano, M. and Pickart, C. and Rechsteiner, M. and Scheffner, M. and Sommer, T. and Tansey, W. and Tyers, M. and Vierstra, R. and Weissman, A. and Wilkinson, K.D. and Wolf, D.
Science 306 (5700): 1290-1292. 1 January 2004

A SNP map of the rat genome generated from cDNA sequences.
Zimdahl, H. and Nyakatura, G. and Brandt, P. and Schulz, H. and Hummel, O. and Fartmann, B. and Brett, D. and Droege, M. and Monti, J. and Lee, Y.A. and Sun, Y.Y. and Zhao, S.Y. and Winter, E.E. and Ponting, C.P. and Chen, Y. and Kasprzyk, A. and Birney, E. and Ganten, D. and Huebner, N.
Science 303 (5659): 807-807. 1 January 2004

2003

Neuroscience - Microglia: The enemy within?
Kempermann, G. and Neumann, H.
Science 302 (5651): 1689-1690. 5 December 2003

Chromosomal instability and tumors promoted by DNA hypomethylation.
Eden, A. and Gaudet, F. and Waghmare, A. and Jaenisch, R.
Science 300 (5618): 455-455. 18 April 2003

Induction of tumors in mice by genomic hypomethylation.
Gaudet, F. and Hodgson, J.G. and Eden, A. and Jackson-Grusby, L. and Dausman, J. and Gray, J.W. and Leonhardt, H. and Jaenisch, R.
Science 300 (5618): 489-492. 18 April 2003

LRP: role in vascular wall integrity and protection from atherosclerosis.
Boucher, P. and Gotthardt, M. and Li, W.P. and Anderson, R.G. and Herz, J.
Science 300 : 329-332. 11 April 2003

Synthesis of serotonin by a second tryptophan hydroxylase isoform.
Walther, D.J. and Peter, J.U. and Bashammakh, S. and Hoertnagl, H. and Voits, M. and Fink, H. and Bader, M.
Science 299 (5603): 76-76. 3 January 2003

2002

The genome sequence of the malaria mosquito Anopheles gambiae.
Holt, R.A. and Subramanian, G.M. and Halpern, A. and Sutton, G.G. and Charlab, R. and Nusskern, D.R. and Wincker, P. and Clark, A.G. and Ribeiro, J.M.C. and Wides, R. and Salzberg, S.L. and Loftus, B. and Yandell, M. and Majoros, W.H. and Rusch, D.B. and Lai, Z.W. and Kraft, C.L. and Abril, J.F. and Anthouard, V. and Arensburger, P. and Atkinson, P.W. and Baden, H. and de Berardinis, V. and Baldwin, D. and Benes, V. and Biedler, J. and Blass, C. and Bolanos, R. and Boscus, D. and Barnstead, M. and Cai, S. and Center, A. and Chatuverdi, K. and Christophides, G.K. and Chrystal, M.A. and Clamp, M. and Cravchik, A. and Curwen, V. and Dana, A. and Delcher, A. and Dew, I. and Evans, C.A. and Flanigan, M. and Grundschober-Freimoser, A. and Friedli, L. and Gu, Z.P. and Guan, P. and Guigo, R. and Hillenmeyer, M.E. and Hladun, S.L. and Hogan, J.R. and Hong, Y.S. and Hoover, J. and Jaillon, O. and Ke, Z.X. and Kodira, C. and Kokoza, E. and Koutsos, A. and Letunic, I. and Levitsky, A. and Liang, Y. and Lin, J.J. and Lobo, N.F. and Lopez, J.R. and Malek, J.A. and McIntosh, T.C. and Meister, S. and Miller, J. and Mobarry, C. and Mongin, E. and Murphy, S.D. and O'Brochta, D.A. and Pfannkoch, C. and Qi, R. and Regier, M.A. and Remington, K. and Shao, H.G. and Sharakhova, M.V. and Sitter, C.D. and Shetty, J. and Smith, T.J. and Strong, R. and Sun, J.T. and Thomasova, D. and Ton, L.Q. and Topalis, P. and Tu, Z.J. and Unger, M.F. and Walenz, B. and Wang, A.H. and Wang, J. and Wang, M. and Wang, X.L. and Woodford, K.J. and Wortman, J.R. and Wu, M. and Yao, A. and Zdobnov, E.M. and Zhang, H.Y. and Zhao, Q. and Zhao, S.Y. and Zhu, S.P.C. and Zhimulev, I. and Coluzzi, M. and della Torre, A. and Roth, C.W. and Louis, C. and Kalush, F. and Mural, R.J. and Myers, E.W. and Adams, M.D. and Smith, H.O. and Broder, S. and Gardner, M.J. and Fraser, C.M. and Birney, E. and Bork, P. and Brey, P.T. and Venter, J.C. and Weissenbach, J. and Kafatos, F.C. and Collins, F.H. and Hoffman, S.L.
Science 298 (5591): 129-149. 4 October 2002

Comparative genome and proteome analysis of Anopheles gambiae and Drosophila melanogaster.
Zdobnov, E.M. and von Mering, C. and Letunic, I. and Torrents, D. and Suyama, M. and Copley, R.R. and Christophides, G.K. and Thomasova, D. and Holt, R.A. and Subramanian, G.M. and Mueller, H.M. and Dimopoulos, G. and Law, J.H. and Wells, M.A. and Birney, E. and Charlab, R. and Halpern, A.L. and Kokoza, E. and Kraft, C.L. and Lai, Z. and Lewis, S. and Louis, C. and Barillas-Mury, C. and Nusskern, D. and Rubin, G.M. and Salzberg, S.L. and Sutton, G.G. and Topalis, P. and Wides, R. and Wincker, P. and Yandell, M. and Collins, F.H. and Ribeiro, J. and Gelbart, W.M. and Kafatos, F.C. and Bork, P.
Science 298 (5591): 149-159. 4 October 2002

Worldwide scientific publishing activity.
Perez-Iratxeta, C. and Andrade, M.A.
Science 297 (5581): 519-519. 26 July 2002

Embryonic stem cells - The debate in Germany.
Reich, J.G.
Science 296 (5566): 265-265. 12 April 2002

Role of a ubiquitin-like modification in polarized morphogenesis.
Dittmar, G.A.G. and Wilkinson, C.R.M. and Jedrzejewski, P.T. and Finley, D.
Science 295 : 2442-2446. 29 March 2002

Mediation of hippocampal mossy fiber long-term potentiation by presynaptic Ih channels.
Mellor, J. and Nicoll, R.A. and Schmitz, D.
Science 295 (5552): 143-147. 4 January 2002

Immunity-related genes and gene families in Anopheles gambiae.
Christophides, G.K. and Zdobnov, E. and Barillas-Mury, C. and Birney, E. and Blandin, S. and Blass, C. and Brey, P.T. and Collins, F.H. and Danielli, A. and Dimopoulos, G. and Hetru, C. and Hoa, N. and Hoffmann, J.A. and Kanzok, S.M. and Letunic, I. and Levashina, E.A. and Loukeris, T.G. and Lycett, G. and Meister, S. and Michel, K. and Mueller, H.M. and Osta, M.A. and Paskewitz, S.M. and Reichhart, J.M. and Rzhetsky, A. and Troxler, L. and Vernick, K.D. and Vlachou, D. and Volz, J. and von Mering, C. and Xu, J.N. and Zheng, L.B. and Bork, P. and Kafatos, F.C.
Science 298 : 159-165. 1 January 2002

2001

CNS synaptogenesis promoted by glia-derived cholesterol.
Mauch, D.H. and Naegler, K. and Schumacher, S. and Goeritz, C. and Mueller, E.C. and Otto, A. and Pfrieger, F.W.
Science 294 (5545): 1354-1357. 9 November 2001

Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice.
Drab, M. and Verkade, P. and Elger, M. and Kasper, M. and Lohn, M. and Lauterbach, B. and Menne, J. and Lindschau, C. and Mende, F. and Luft, F.C. and Schedl, A. and Haller, H. and Kurzchalia, T.V.
Science 293 (5539): 2449-2452. 28 September 2001

Presynaptic kainate receptor mediation of frequency facilitation at hippocampal mossy fiber synapses.
Schmitz, D. and Mellor, J. and Nicoll, R.A.
Science 291 (5510): 1972-1976. 9 March 2001

Sequence interpretation - Functional annotation of mouse genome sequences.
Nadeau, J.H. and Balling, R. and Barsh, G. and Beier, D. and Brown, S.D.M. and Bucan, M. and Camper, S. and Carlson, G. and Copeland, N. and Eppig, J. and Fletcher, C. and Frankel, W.N. and Ganten, D. and Goldowitz, D. and Goodnow, C. and Guenet, J.L. and Hicks, G. and de Angelis, M.H. and Jackson, I. and Jacob, H.J. and Jenkins, N. and Johnson, D. and Justice, M. and Kay, S. and Kingsley, D. and Lehrach, H. and Magnuson, T. and Meisler, M. and Poustka, A.M. and Rinchik, E.M. and Rossant, J. and Russell, L.B. and Schimenti, J. and Shiroishi, T. and Skarnes, W.C. and Soriano, P. and Stanford, W. and Takahashi, J.S. and Wurst, W. and Zimmer, A.
Science 291 : 1251-1255. 1 January 2001

Cooperation and competition in the evolution of ATP-producing pathways.
Pfeiffer, T. and Schuster, S. and Bonhoeffer, S.
Science 292 : 504-507. 1 January 2001

1999

Lateral gene transfer, genome surveys, and the phylogeny of prokaryotes.
Huynen, M.A. and Snel, B. and Bork, P.
Science 286 (5444): 1443a. 19 November 1999

View from the east.
Reich, J.G.
Science 286 (5442): 1087-1087. 5 November 1999

1998

Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta.
Behrens, J. and Jerchow, B.A. and Wuertele, M. and Grimm, J. and Asbrand, C. and Wirtz, R. and Kuehl, M. and Wedlich, D. and Birchmeier, W.
Science 280 (5363): 596-599. 24 April 1998

A potassium channel mutation in neonatal human epilepsy.
Biervert, C. and Schroeder, B.C. and Kubisch, C. and Berkovic, S.F. and Propping, P. and Jentsch, T.J. and Steinlein, O.K.
Science 279 (5349): 403-406. 16 January 1998

1997

Role of Cue1p in ubiquitination and degradition at the ER surface.
Biederer, T. and Volkwein, C. and Sommer, T.
Science 278 (5344): 1806-1809. 5 December 1997

Gene families: the taxonomy of protein paralogs and chimeras.
Henikoff, S. and Greene, E.A. and Pietrokovski, S. and Bork, P. and Attwood, T.K. and Hood, L.
Science 278 (5338): 609-614. 24 October 1997

Synaptic efficacy enhanced by glial cells in vitro.
Pfrieger, F.W. and Barres, B.A.
Science 277 (5332): 1684-1687. 12 September 1997

Genome maps 8. Building gene families. Wall chart.
Greene, E.A. and Pietrokovski, S. and Henikoff, S. and Bork, P. and Attwood, T.K. and Hood, L. and Bairoch, A.
Science 278 : 615-626. 1 January 1997

1996

Neurogenic amplification of immune complex inflammation.
Bozic, C.R. and Lu, B. and Hoepken, U.E. and Gerard, C. and Gerard, N.P.
Science 273 (5282): 1722-1725. 20 September 1996

Sperm-egg binding protein or proto-oncogene?
Bork, P.
Science 271 (5254): 1431-1432. 1 January 1996

1995

Separation of origin recognition complex functions by cross-species complementation.
Ehrenhofer-Murray, A.E. and Gossen, M. and Pak, D.T. and Botchan, M.R. and Rine, J.
Science 270 (5242): 1671-1674. 8 December 1995

A Drosophila homolog of the yeast origin recognition complex.
Gossen, M. and Pak, D.T. and Hansen, S.K. and Acharya, J.K. and Botchan, M.R.
Science 270 (5242): 1674-1677. 8 December 1995

Inducible gene targeting in mice.
Kuehn, R. and Schwenk, F. and Aguet, M. and Rajewsky, K.
Science 269 (5229): 1427-1429. 8 September 1995

Transcriptional activation by tetracyclines in mammalian cells.
Gossen, M. and Freundlieb, S. and Bender, G. and Muller, G. and Hillen, W. and Bujard, H.
Science 268 (5218): 1766-1769. 23 June 1995

1994

MHC class I expression in mice lacking the proteasome subunit LMP-7.
Fehling, H.J. and Swat, W. and Laplace, C. and Kuehn, R. and Rajewsky, K. and Mueller, U. and von Boehmer, H.
Science 265 (5176): 1234-1237. 26 August 1994

Resistance to murine acquired immunodeficiency syndrome (MAIDS).
Morawetz, R.A. and Doherty, T.M. and Giese, N.A. and Hartley, J.W. and Mueller, W. and Kuehn, R. and Rajewsky, K. and Coffman, R. and Morse, H.C.
Science 265 (5169): 264-266. 8 July 1994

Inhibition of hepatic chylomicron remnant uptake by gene transfer of a receptor antagonist.
Willnow, T.E. and Sheng, Z. and Ishibashi, S. and Herz, J.
Science 264 (5164): 1471-1474. 3 June 1994

Structure of the Tet repressor-tetracycline complex and regulation of antibiotic resistance.
Hinrichs, W. and Kisker, C. and Duevel, M. and Mueller, A. and Tovar, K. and Hillen, W. and Saenger, W.
Science 264 (5157): 418-420. 15 April 1994

1992

Transport of proteins across the endoplasmic reticulum membrane.
Rapoport, T.A.
Science 258 (5084): 931-936. 6 November 1992

The skeletal muscle chloride channel in dominant and recessive human myotonia.
Koch, M.C. and Steinmeyer, K. and Lorenz, C. and Ricker, K. and Wolf, F. and Otto, M. and Zoll, B. and Lehmann-Horn, F. and Grzeschik, K.H. and Jentsch, T.J.
Science 257 (5071): 797-800. 7 August 1992

Calcium entry through kainate receptors and resulting potassium- channel blockade in Bergmann glial cells.
Mueller, T. and Moeller, T. and Berger, T. and Schnitzer-Ungefug, J. and Kettenmann, H.
Science 256 (5063): 1563-1566. 12 June 1992

1991

Generation and analysis of interleukin-4 deficient mice.
Kuehn, R. and Rajewsky, K. and Mueller, W.
Science 254 (5032): 707-710. 1 November 1991

This list was generated on Wed Oct 17 02:25:29 2018 CEST.
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