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2018

Novel calcineurin A (PPP3CA) variant associated with epilepsy, constitutive enzyme activation and downregulation of protein expression.
Rydzanicz, M. and Wachowska, M. and Cook, E.C. and Lisowski, P. and Kuźniewska, B. and Szymańska, K. and Diecke, S. and Prigione, A. and Szczałuba, K. and Szybińska, A. and Koppolu, A. and Murcia Pienkowski, V. and Kosińska, J. and Wiweger, M. and Kostrzewa, G. and Brzozowska, M. and Domańska-Pakieła, D. and Jurkiewicz, E. and Stawiński, P. and Gromadka, A. and Zielenkiewicz, P. and Demkow, U. and Dziembowska, M. and Kuźnicki, J. and Creamer, T.P. and Płoski, R.
European Journal of Human Genetics 25 September 2018 (In Press)

mHTT seeding activity: a marker of disease progression and neurotoxicity in models of Huntington's disease.
Ast, A. and Buntru, A. and Schindler, F. and Hasenkopf, R. and Schulz, A. and Brusendorf, L. and Klockmeier, K. and Grelle, G. and McMahon, B. and Niederlechner, H. and Jansen, I. and Diez, L. and Edel, J. and Boeddrich, A. and Franklin, S.A. and Baldo, B. and Schnoegl, S. and Kunz, S. and Purfürst, B. and Gaertner, A. and Kampinga, H.H. and Morton, A.J. and Petersén, Å. and Kirstein, J. and Bates, G.P. and Wanker, E.E.
Molecular Cell 71 (5): 675-688. 6 September 2018

Metformin reverses early cortical network dysfunction and behavior changes in Huntington's disease.
Arnoux, I. and Willam, M. and Griesche, N. and Krummeich, J. and Watari, H. and Offermann, N. and Weber, S. and Narayan Dey, P. and Chen, C. and Monteiro, O. and Buettner, S. and Meyer, K. and Bano, D. and Radyushkin, K. and Langston, R. and Lambert, J.J. and Wanker, E. and Methner, A. and Krauss, S. and Schweiger, S. and Stroh, A.
eLife 7 : e38744. 4 September 2018

LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells.
Trepte, P. and Kruse, S. and Kostova, S. and Hoffmann, S. and Buntru, A. and Tempelmeier, A. and Secker, C. and Diez, L. and Schulz, A. and Klockmeier, K. and Zenkner, M. and Golusik, S. and Rau, K. and Schnoegl, S. and Garner, C.C. and Wanker, E.E.
Molecular Systems Biology 14 (7): e8071. 11 July 2018

Reducing mutant huntingtin protein expression in living cells by a newly identified RNA CAG binder.
Matthes, F. and Massari, S. and Bochicchio, A. and Schorpp, K. and Schilling, J. and Weber, S. and Offermann, N. and Desantis, J. and Wanker, E.E. and Carloni, P. and Hadian, K. and Tabarrini, O. and Rossetti, G. and Krauss, S.
ACS Chemical Neuroscience 9 (6): 1399-1408. 20 June 2018

Self-assembly of mutant huntingtin exon-1 fragments into large complex fibrillar structures involves nucleated branching.
Wagner, A.S. and Politi, A.Z. and Ast, A. and Bravo-Rodriguez, K. and Baum, K. and Buntru, A. and Strempel, N.U. and Brusendorf, L. and Hänig, C. and Boeddrich, A. and Plassmann, S. and Klockmeier, K. and Ramirez-Anguita, J.M. and Sanchez-Garcia, E. and Wolf, J. and Wanker, E.E.
Journal of Molecular Biology 430 (12): 1725-1744. 8 June 2018

The CRISPR/Cas9 system sheds new lights on the biology of protozoan parasites.
Grzybek, M. and Golonko, A. and Górska, A. and Szczepaniak, K. and Strachecka, A. and Lass, A. and Lisowski, P.
Applied Microbiology and Biotechnology 102 (11): 4629-4640. June 2018

Mitochondria and the dynamic control of stem cell homeostasis.
Lisowski, P. and Kannan, P. and Mlody, B. and Prigione, A.
EMBO Reports 19 (5): e45432. 1 May 2018

Pluripotent stem cells for uncovering the role of mitochondria in human brain function and dysfunction.
Zink, A. and Priller, J. and Prigione, A.
Journal of Molecular Biology 430 (7): 891-903. 30 March 2018

Inhibition of the MID1 protein complex: a novel approach targeting APP protein synthesis.
Matthes, F. and Hettich, M.M. and Schilling, J. and Flores-Dominguez, D. and Blank, N. and Wiglenda, T. and Buntru, A. and Wolf, H. and Weber, S. and Vorberg, I. and Dagane, A. and Dittmar, G. and Wanker, E. and Ehninger, D. and Krauss, S.
Cell Death Discovery 4 : 4. 29 January 2018

Epigallocatechin gallate (EGCG) reduces the intensity of pancreatic amyloid fibrils in human islet amyloid polypeptide (hIAPP) transgenic mice.
Franko, A. and Rodriguez Camargo, D.C. and Böddrich, A. and Garg, D. and Rodriguez Camargo, A. and Rathkolb, B. and Janik, D. and Aichler, M. and Feuchtinger, A. and Neff, F. and Fuchs, H. and Wanker, E.E. and Reif, B. and Häring, H.U. and Peter, A. and Hrabě de Angelis, M.
Scientific Reports 8 (1): 1116. 18 January 2018

Complete suppression of Htt fibrilization and disaggregation of Htt fibrils by a trimeric chaperone complex.
Scior, A. and Buntru, A. and Arnsburg, K. and Ast, A. and Iburg, M. and Juenemann, K. and Pigazzini, M.L. and Mlody, B. and Puchkov, D. and Priller, J. and Wanker, E.E. and Prigione, A. and Kirstein, J.
EMBO Journal 37 (2): 282-299. 17 January 2018

A novel RNA editing sensor tool and a specific agonist determine neuronal protein expression of RNA-edited glycine receptors and identify a genomic APOBEC1 dimorphism as a new genetic risk factor of epilepsy.
Kankowski, S. and Förstera, B. and Winkelmann, A. and Knauff, P. and Wanker, E.E. and You, X.A. and Semtner, M. and Hetsch, F. and Meier, J.C.
Frontiers in Molecular Neuroscience 10 : 439. 11 January 2018

Human mesenchymal factors induce rat hippocampal- and human neural stem cell dependent oligodendrogenesis.
Jadasz, J.J. and Tepe, L. and Beyer, F. and Samper Agrelo, I. and Akkermann, R. and Spitzhorn, L.S. and Silva, M.E. and Oreffo, R.O.C. and Hartung, H.P. and Prigione, A. and Rivera, F.J. and Adjaye, J. and Kuery, P.
Glia 66 (1): 145-160. January 2018

A filter retardation assay facilitates the detection and quantification of heat-stable, amyloidogenic mutant huntingtin aggregates in complex biosamples.
Ast, A. and Schindler, F. and Buntru, A. and Schnoegl, S. and Wanker, E.E.
Methods in Molecular Biology 1780 : 31-40. 2018

Engineering of human-induced pluripotent stem cells for precise disease modeling.
Lisowski, P.
In: Stem Cell Genetics for Biomedical Research: Past, Present, and Future. Springer, Cham, Switzerland, 369-411. ISBN 978-3-319-90694-2 2018

2017

Mitochondrial metabolism in early neural fate and its relevance for neuronal disease modeling.
Lorenz, C. and Prigione, A.
Current Opinion in Cell Biology 49 : 71-76. December 2017

Human SLFN5 is a transcriptional co-repressor of STAT1-mediated interferon responses and promotes the malignant phenotype in glioblastoma.
Arslan, A.D. and Sassano, A. and Saleiro, D. and Lisowski, P. and Kosciuczuk, E.M. and Fischietti, M. and Eckerdt, F. and Fish, E.N. and Platanias, L.C.
Oncogene 36 (43): 6006-6019. 26 October 2017

Fibril branching dominates self-assembly of mutant huntingtin exon-1 aggregates in vitro.
Wagner, A.S. and Politi, A.Z. and Steinhof, A. and Bravo-Rodriguez, K. and Buntru, A. and Strempel, N.U. and Brusendorf, L. and Haenig, C. and Boeddrich, A. and Plassmann, S. and Ramirez-Anguita, J.M. and Baum, K. and Sanchez-Garcia, E. and Wolf, J. and Wanker, E.E.
bioRxiv : 195297. 19 October 2017

Nijmegen Breakage Syndrome fibroblasts and iPSCs: cellular models for uncovering disease-associated signaling pathways and establishing a screening platform for anti-oxidants.
Mlody, B. and Wruck, W. and Martins, S. and Sperling, K. and Adjaye, J.
Scientific Reports 7 (1): 7516. 8 August 2017

Concise review: Induced pluripotent stem cell-based drug discovery for mitochondrial disease.
Inak, G. and Lorenz, C. and Lisowski, P. and Zink, A. and Mlody, B. and Prigione, A.
Stem Cells 35 (7): 1655-1662. July 2017

Gene editing and clonal isolation of human induced pluripotent stem cells using CRISPR/Cas9.
Yumlu, S. and Stumm, J. and Bashir, S. and Dreyer, A.K. and Lisowski, P. and Danner, E. and Kühn, R.
Methods 121-122 : 29-44. 15 May 2017

Human iPSC-derived neural progenitors are an effective drug discovery model for neurological mtDNA disorders.
Lorenz, C. and Lesimple, P. and Bukowiecki, R. and Zink, A. and Inak, G. and Mlody, B. and Singh, M. and Semtner, M. and Mah, N. and Auré, K. and Leong, M. and Zabiegalov, O. and Lyras, E.M. and Pfiffer, V. and Fauler, B. and Eichhorst, J. and Wiesner, B. and Huebner, N. and Priller, J. and Mielke, T. and Meierhofer, D. and Izsvák, Z. and Meier, J.C. and Bouillaud, F. and Adjaye, J. and Schuelke, M. and Wanker, E.E. and Lombès, A. and Prigione, A.
Cell Stem Cell 20 (5): 659-674.e9. 4 May 2017

Inhibition of huntingtin exon-1 aggregation by the molecular tweezer CLR01.
Vöpel, T. and Bravo-Rodriguez, K. and Mittal, S. and Vachharajani, S. and Gnutt, D. and Sharma, A. and Steinhof, A. and Fatoba, O. and Ellrichmann, G. and Nshanian, M. and Heid, C. and Loo, J.A. and Klärner, F.-G. and Schrader, T. and Bitan, G. and Wanker, E.E. and Ebbinghaus, S. and Sanchez-Garcia, E.
Journal of the American Chemical Society 139 (16): 5640-5643. 26 April 2017

Identification of an RNA polymerase III regulator linked to disease-associated protein aggregation.
Sin, O. and de Jong, T. and Mata-Cabana, A. and Kudron, M. and Zaini, M.A. and Aprile, F.A. and Seinstra, R.I. and Stroo, E. and Prins, R.W. and Martineau, C.N. and Wang, H.H. and Hogewerf, Wytse and Steinhof, A. and Wanker, E.E. and Vendruscolo, M. and Calkhoven, C.F. and Reinke, V. and Guryev, V. and Nollen, E.A.A.
Molecular Cell 65 (6): 1096-1108. 16 March 2017

The redox environment triggers conformational changes and aggregation of hIAPP in type II diabetes.
Rodriguez Camargo, D.C. and Tripsianes, K. and Buday, K. and Franko, A. and Göbl, C. and Hartlmüller, C. and Sarkar, R. and Aichler, M. and Mettenleiter, G. and Schulz, M. and Böddrich, A. and Erck, C. and Martens, H. and Walch, A.K. and Madl, T. and Wanker, E.E. and Conrad, M. and de Angelis, M.H. and Reif, B.
Scientific Reports 7 : 44041. 13 March 2017

Epigenetics of cell fate reprogramming and its implications for neurological disorders modelling.
Grzybek, M. and Golonko, A. and Walczak, M. and Lisowski, P.
Neurobiology of Disease 99 : 84-120. March 2017

Aggregation of full length immunoglobulin light chains from AL amyloidosis patients is remodeled by epigallocatechin-3-gallate.
Andrich, K. and Hegenbart, U. and Kimmich, C. and Kedia, N. and Bergen, H.R. and Schönland, S. and Wanker, E.E. and Bieschke, J.
Journal of Biological Chemistry 292 (6): 2328-2344. 10 February 2017

Aggregation-induced changes in the chemical exchange saturation transfer (CEST) signals of proteins.
Goerke, S. and Milde, K.S. and Bukowiecki, R. and Kunz, P. and Klika, K.D. and Wiglenda, T. and Mogk, A. and Wanker, E.E. and Bukau, B. and Ladd, M.E. and Bachert, P. and Zaiss, M.
NMR in Biomedicine 30 (1): e3665. January 2017

2016

A movement disorder with dystonia and ataxia caused by a mutation in the HIBCH gene.
Schottmann, G. and Sarpong, A. and Lorenz, C. and Weinhold, N. and Gill, E. and Teschner, L. and Ferdinandusse, S. and Wanders, R.J.A. and Prigione, A. and Schuelke, M.
Movement Disorders 31 (11): 1733-1739. November 2016

Age-dependent differential expression of death-associated protein 6 (Daxx) in various peripheral tissues and different brain regions of C57BL/6 male mice.
Lessard-Beaudoin, M. and Laroche, M. and Demers, M.J. and Duclos, C. and Denault, J.B. and Grenier, G. and Riechers, S.P. and Wanker, E.E. and Graham, R.K.
Biogerontology 17 (5): 817-828. November 2016

Organ-specific alteration in caspase expression and STK3 proteolysis during the aging process.
Lessard-Beaudoin, M. and Laroche, M. and Loudghi, A. and Demers, M.J. and Denault, J.B. and Grenier, G. and Riechers, S.P. and Wanker, E.E. and Graham, R.K.
Neurobiology of Aging 47 : 50-62. November 2016

Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers.
Arumughan, A. and Roske, Y. and Barth, C. and Lleras Forero, L. and Bravo-Rodriguez, K. and Redel, Al. and Kostova, S. and McShane, E. and Opitz, R. and Faelber, K. and Rau, K. and Mielke, T. and Daumke, O. and Selbach, M. and Sanchez-Garcia, E. and Rocks, O. and Panáková, D. and Heinemann, U. and Wanker, E.E.
Nature Communications 7 : 13047. 20 October 2016

A glycolytic solution for pluripotent stem cells.
Mlody, B. and Prigione, A.
Cell Stem Cell 19 (4): 419-420. 6 October 2016

Immunoadsorption of agonistic autoantibodies against α1-adrenergic receptors in patients with mild to moderate dementia.
Hempel, P. and Heinig, B. and Jerosch, C. and Decius, I. and Karczewski, P. and Kassner, U. and Kunze, R. and Steinhagen-Thiessen, E. and Bimmler, M.
Therapeutic Apheresis and Dialysis 20 (5): 523-529. October 2016

Amyloid-β(1-42) aggregation initiates its cellular uptake and cytotoxicity.
Jin, S. and Kedia, N. and Illes-Toth, E. and Haralampiev, I. and Prisner, S. and Herrmann, A. and Wanker, E.E. and Bieschke, J.
Journal of Biological Chemistry 291 (37): 19590-19606. 9 September 2016

Aging vs. rejuvenation: reprogramming to iPSCs does not turn back the clock for somatic mitochondrial DNA mutations.
Lorenz, C. and Prigione, A.
Stem Cell Investigation 3 : 43. September 2016

An integer programming framework for inferring disease complexes from network data.
Mazza, A. and Klockmeier, K. and Wanker, E. and Sharan, R.
Bioinformatics 32 (12): i271-i277. 15 June 2016

Functional characterisation of human synaptic genes expressed in the Drosophila brain.
Zografos, L. and Tang, J. and Hesse, F. and Wanker, E.E. and Li, K.W. and Smit, A.B. and Davies, R.W. and Armstrong, J.D.
Biology Open 5 (5): 662-667. 15 May 2016

Current approaches toward quantitative mapping of the interactome.
Buntru, A. and Trepte, P. and Klockmeier, K. and Schnoegl, S. and Wanker, E.E.
Frontiers in Genetics 7 : 74. 4 May 2016

Interactome network analysis identifies multiple caspase-6 interactors involved in the pathogenesis of HD.
Riechers, S.P. and Butland, S. and Deng, Y. and Skotte, N. and Ehrnhoefer, D.E. and Russ, J. and Laine, J. and Laroche, M. and Pouladi, M.A. and Wanker, E.E. and Hayden, M.R. and Graham, R.K.
Human Molecular Genetics 25 (8): 1600-1618. May 2016

Optimization of the All-D peptide D3 for Aβ oligomer elimination.
Klein, A.N. and Ziehm, T. and Tusche, M. and Buitenhuis, J. and Bartnik, D. and Boeddrich, A. and Wiglenda, T. and Wanker, E. and Funke, S.A. and Brener, O. and Gremer, L. and Kutzsche, J. and Willbold, D.
PLoS ONE 11 (4): e0153035. 22 April 2016

A mitochondrial view of cell fate.
Prigione, A.
Seminars in Cell & Developmental Biology 52 : 66-67. April 2016

Energy metabolism in neuronal/glial induction and iPSC-based modeling of brain disorders.
Mlody, B. and Lorenz, C. and Inak, G. and Prigione, A.
Seminars in Cell & Developmental Biology 52 : 102-109. April 2016

Combined fluorescence and phosphorescence lifetime imaging.
Shcheslavskiy, V.I. and Neubauer, A. and Bukowiecki, R. and Dinter, F. and Becker, W.
Applied Physics Letters 108 (9): 091111. 3 March 2016

Novel small molecules targeting ciliary transport of Smoothened and oncogenic Hedgehog pathway activation.
Jung, B. and Messias, A.C. and Schorpp, K. and Geerlof, A. and Schneider, G. and Saur, D. and Hadian, K. and Sattler, M. and Wanker, E.E. and Hasenöder, S. and Lickert, H.
Scientific Reports 6 : 22540. 2 March 2016

Isolation and cultivation of naive-like human pluripotent stem cells based on HERVH expression.
Wang, J. and Singh, M. and Sun, C. and Besser, D. and Prigione, A. and Ivics, Z. and Hurst, L.D. and Izsvák, Z.
Nature Protocols 11 (2): 327-346. February 2016

2015

Annexin A1 sustains tumor metabolism and cellular proliferation upon stable loss of HIF1A.
Rohwer, N. and Bindel, F. and Grimm, C. and Lin, S.J. and Wappler, J. and Klinger, B. and Blüthgen, N. and Du Bois, I. and Schmeck, B. and Lehrach, H. and de Graauw, M. and Goncalves, E. and Saez-Rodriguez, J. and Tan, P. and Grabsch, H.I. and Prigione, A. and Kempa, S. and Cramer, T.
Oncotarget 7 (6): 6693-6710. 29 December 2015

DULIP: A dual luminescence-based co-immunoprecipitation assay for interactome mapping in mammalian cells.
Trepte, P. and Buntru, A. and Klockmeier, K. and Willmore, L. and Arumughan, A. and Secker, C. and Zenkner, M. and Brusendorf, L. and Rau, K. and Redel, A. and Wanker, E.E.
Journal of Molecular Biology 427 (21): 3375-3388. 23 October 2015

Corticotropin-releasing hormone receptor type 1 (CRHR1) clustering with MAGUKs is mediated via its C-terminal PDZ binding motif.
Bender, J. and Engeholm, M. and Ederer, M.S. and Breu, J. and Møller, T.C. and Michalakis, S. and Rasko, T. and Wanker, E.E. and Biel, M. and Martinez, K.L. and Wurst, W. and Deussing, J.M.
PLoS ONE 10 (9): e0136768. 9 September 2015

Reduced SNAP-25 increases PSD-95 mobility and impairs spine morphogenesis.
Fossati, G. and Morini, R. and Corradini, I. and Antonucci, F. and Trepte, P. and Edry, E. and Sharma, V. and Papale, A. and Pozzi, D. and Defilippi, P. and Meier, J.C. and Brambilla, R. and Turco, E. and Rosenblum, K. and Wanker, E.E. and Ziv, N.E. and Menna, E. and Matteoli, M.
Cell Death and Differentiation 22 (9): 1425-1436. September 2015

The return of metabolism: biochemistry and physiology of the pentose phosphate pathway.
Stincone, A. and Prigione, A. and Cramer, T. and Wamelink, M.M.C. and Campbell, K. and Cheung, E. and Olin-Sandoval, V. and Gruening, N.M. and Krueger, A. and Tauqeer Alam, M. and Keller, M.A. and Breitenbach, M. and Brindle, K.M. and Rabinowitz, J.D. and Ralser, M.
Biological Reviews 90 (3): 927-963. August 2015

Quantitative interaction proteomics of neurodegenerative disease proteins.
Hosp, F. and Vossfeldt, H. and Heinig, M. and Vasiljevic, D. and Arumughan, A. and Wyler, E. and Landthaler, M. and Hubner, N. and Wanker, E.E. and Lannfelt, L. and Ingelsson, M. and Lalowski, M. and Voigt, A. and Selbach, M.
Cell Reports 11 (7): 1134-1146. 19 May 2015

Metabolic restructuring and cell fate conversion.
Prigione, A. and Ruiz-Perez, M.V. and Bukowiecki, R. and Adjaye, J.
Cellular and Molecular Life Sciences 72 (9): 1759-1777. 1 May 2015

Systematic interaction network filtering identifies CRMP1 as a novel suppressor of huntingtin misfolding and neurotoxicity.
Stroedicke, M. and Bounab, Y. and Strempel, N. and Klockmeier, K. and Yigit, S. and Friedrich, R.P. and Chaurasia, G. and Li, S. and Hesse, F. and Riechers, S.P. and Russ, J. and Nicoletti, C. and Boeddrich, A. and Wiglenda, T. and Haenig, C. and Schnoegl, S. and Fournier, D. and Graham, R.K. and Hayden, M.R. and Sigrist, S. and Bates, G.P. and Priller, J. and Andrade-Navarro, M.A. and Futschik, M.E. and Wanker, E.E.
Genome Research 25 (5): 701-713. May 2015

Central role of ULK1 in type I interferon signaling.
Saleiro, D. and Mehrotra, S. and Kroczynska, B. and Beauchamp, E.M. and Lisowski, P. and Majchrzak-Kita, B. and Bhagat, T.D. and Stein, B.L. and McMahon, B. and Altman, J.K. and Kosciuczuk, E.M. and Baker, D.P. and Jie, C. and Jafari, N. and Thompson, C.B. and Levine, R.L. and Fish, E.N. and Verma, A.K. and Platanias, L.C.
Cell Reports 11 (4): 605-617. 28 April 2015

Modulation of human IAPP fibrillation: cosolutes, crowders and chaperones.
Gao, M. and Estel, K. and Seeliger, J. and Friedrich, R.P. and Dogan, S. and Wanker, E.E. and Winter, R. and Ebbinghaus, S.
Physical Chemistry Chemical Physics 17 (13): 8338-8348. 7 April 2015

In utero gene therapy rescues microcephaly caused by Pqbp1-hypofunction in neural stem progenitor cells.
Ito, H. and Shiwaku, H. and Yoshida, C. and Homma, H. and Luo, H. and Chen, X. and Fujita, K. and Musante, L. and Fischer, U. and Frints, S.G.M. and Romano, C. and Ikeuchi, Y. and Shimamura, T. and Imoto, S. and Miyano, S. and Muramatsu, S.I. and Kawauchi, T. and Hoshino, M. and Sudol, M. and Arumughan, A. and Wanker, E.E. and Rich, T. and Schwartz, C. and Matsuzaki, F. and Bonni, A. and Kalscheuer, V.M. and Okazawa, H.
Molecular Psychiatry 20 (4): 459-471. April 2015

Anti-inflammatory effects of atorvastatin treatment in chronic obstructive pulmonary disease. A controlled pilot study.
Mroz, R.M. and Lisowski, P. and Tycinska, A. and Bierla, J. and Trzeciak, P.Z. and Minarowski, L. and Milewski, R. and Lisowska, A. and Boros, P. and Sobkowicz, B. and Duszewska, A.M. and Chyczewska, E. and Musial, W.J. and MacNee, W.
Journal of Physiology and Pharmacology 66 (1): 111-128. February 2015

Induced pluripotent stem cells (iPSCs) for modeling mitochondrial DNA disorders.
Prigione, A.
Methods in Molecular Biology 1265 : 349-356. 6 January 2015

The green tea polyphenol (-)-epigallocatechin gallate prevents the aggregation of tau protein into toxic oligomers at substoichiometric ratios.
Wobst, H.J. and Sharma, A. and Diamond, M.I. and Wanker, E.E. and Bieschke, J.
FEBS Letters 589 (1): 77-83. 2 January 2015

Assessing the bioenergetic profile of human pluripotent stem cells.
Pfiffer, V. and Prigione, A.
Methods in Molecular Biology 1264 : 279-288. 2015

The effect of (-)-Epigallo-catechin-(3)-gallate on amyloidogenic proteins suggests a common mechanism.
Andrich, K. and Bieschke, J.
Advances in Experimental Medicine and Biology 863 : 139-161. 2015

2014

Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells.
Wang, J. and Xie, G. and Singh, M. and Ghanbarian, A.T. and Raskó, T. and Szvetnik, A. and Cai, H. and Besser, D. and Prigione, A. and Fuchs, N.V. and Schumann, G.G. and Chen, W. and Lorincz, M.C. and Ivics, Z. and Hurst, L.D. and Izsvák, Z.
Nature 516 (7531): 405-409. 18 December 2014

Social stress increases expression of hemoglobin genes in mouse prefrontal cortex.
Stankiewicz, A.M. and Goscik, J. and Swiergiel, A.H. and Majewska, A. and Wieczorek, M. and Juszczak, G.R. and Lisowski, P.
BMC Neuroscience 15 (1): 130. 4 December 2014

The E3-ubiquitin ligase MID1 catalyzes ubiquitination and cleavage of Fu.
Schweiger, S. and Dorn, S. and Fuchs, M. and Köhler, A. and Matthes, F. and Müller, E.C. and Wanker, E. and Schneider, R. and Krauß, S.
Journal of Biological Chemistry 289 (46): 31805-31817. 14 November 2014

Cupulin is a zona pellucida-like domain protein and major component of the cupula from the inner ear.
Dernedde, J. and Weise, C. and Mueller, E.C. and Hagiwara, A. and Bachmann, S. and Suzuki, M. and Reutter, W. and Tauber, R. and Scherer, H.
PLoS ONE 9 (11): e111917. 4 November 2014

Identification of the mitochondrial MSRB2 as a binding partner of LG72.
Otte, D.M. and Raskó, T. and Wang, M. and Dreiseidler, M. and Drews, E. and Schrage, H. and Wojtalla, A. and Höhfeld, J. and Wanker, E. and Zimmer, A.
Cellular and Molecular Neurobiology 34 (8): 1123-1130. November 2014

Characterizing protein interactions employing a genome-wide siRNA cellular phenotyping screen.
Suratanee, A. and Schaefer, M.H. and Betts, M.J. and Soons, Z. and Mannsperger, H. and Harder, N. and Oswald, M. and Gipp, M. and Ramminger, E. and Marcus, G. and Männer, R. and Rohr, K. and Wanker, E. and Russell, R.B. and Andrade-Navarro, M.A. and Eils, R. and König, R.
PLoS Computational Biology 10 (9): e1003814. 25 September 2014

Prion-like proteins sequester and suppress the toxicity of huntingtin exon 1.
Kayatekin, C. and Matlack, K.E.S. and Hesse, W.R. and Guan, Y. and Chakrabortee, S. and Russ, J. and Wanker, E.E. and Shah, J.V. and Lindquist, S.
Proceedings of the National Academy of Sciences of the United States of America 111 (33): 12085-12090. 19 August 2014

Spontaneous self-assembly of pathogenic huntingtin exon 1 protein into amyloid structures.
Trepte, P. and Strempel, N. and Wanker, E.E.
Essays in Biochemistry 56 (1): 167-180. 18 August 2014

The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease.
Butland, S.L. and Sanders, S.S. and Schmidt, M.E. and Riechers, S.P. and Lin, D.T.S. and Martin, D.D.O. and Vaid, K. and Graham, R.K. and Singaraja, R.R. and Wanker, E.E. and Conibear, E. and Hayden, M.R.
Human Molecular Genetics 23 (15): 4142-4160. 1 August 2014

Evidence for the interaction of Endophilin A3 with endogenous K(Ca)2.3 channels in PC12 cells.
Janbein, M. and Quader, M.A. and Hoppner, A.C. and Grüner, I. and Wanker, E. and Wälter, S. and Küppers, E. and Grissmer, S. and Jäger, H.
Cellular Physiology and Biochemistry 34 (2): 474-490. 30 July 2014

Polyglutamine-rich suppressors of huntingtin toxicity act upstream of hsp70 and sti1 in spatial quality control of amyloid-like proteins.
Wolfe, K.J. and Ren, H.Y. and Trepte, P. and Cyr, D.M.
PLoS ONE 9 (5): e95914. 14 May 2014

Annexin A2 mediates apical trafficking of renal Na(+)-K(+)-2Cl(-)-cotransporter.
Dathe, C. and Daigeler, A.L. and Seifert, W. and Jankowski, V. and Mrowka, R. and Kalis, R. and Wanker, E. and Mutig, K. and Bachmann, S. and Paliege, A.
Journal of Biological Chemistry 289 (14): 9983-9997. 4 April 2014

A mitochondrial strategy for safeguarding the reprogrammed genome.
Prigione, A. and Adjaye, J.
Cell Regeneration 3 (1): 5. 29 March 2014

HIF1α modulates reprogramming through early glycolytic shift and up-regulation of PDK1-3 and PKM2.
Prigione, A. and Rohwer, N. and Hoffman, S. and Mlody, B. and Drews, K. and Bukowiecki, R. and Bluemlein, K. and Wanker, E.E. and Ralser, M. and Cramer, T. and Adjaye, J.
Stem Cells 32 (2): 364-376. February 2014

Mitochondrial function in pluripotent stem cells and cellular reprogramming.
Bukowiecki, R. and Adjaye, J. and Prigione, A.
Gerontology 60 (2): 174-182. February 2014

2013

Myc inhibition impairs autophagosome formation.
Toh, P.P.C. and Luo, S. and Menzies, F.M. and Raskó, T. and Wanker, E.E. and Rubinsztein, D.C.
Human Molecular Genetics 22 (25): 5237-5248. 20 December 2013

The Hsp70/90 cochaperone, Sti1, suppresses proteotoxicity by regulating spatial quality control of amyloid-like proteins.
Wolfe, K.J. and Ren, H.Y. and Trepte, P. and Cyr, D.M.
Molecular Biology of the Cell 24 (23): 3588-3602. December 2013

HDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration.
Mielcarek, M. and Landles, C. and Weiss, A. and Bradaia, A. and Seredenina, T. and Inuabasi, L. and Osborne, G.F. and Wadel, K. and Touller, C. and Butler, R. and Robertson, J. and Franklin, S.A. and Smith, D.L. and Park, L. and Marks, P.A. and Wanker, E.E. and Olson, E.N. and Luthi-Carter, R. and van der Putten, H. and Beaumont, V. and Bates, G.P.
PLoS Biology 11 (11): e1001717. November 2013

SUMO-2 and PIAS1 modulate insoluble mutant Huntingtin protein accumulation.
O'Rourke, J.G. and Gareau, J.R. and Ochaba, J. and Song, W. and Raskó, T. and Reverter, D. and Lee, J. and Monteys, A.M. and Pallos, J. and Mee, L. and Vashishtha, M. and Apostol, B.L. and Nicholson, T.P. and Illes, K. and Zhu, Y.Z. and Dasso, M. and Bates, G.P. and Difiglia, M. and Davidson, B. and Wanker, E.E. and Marsh, J.L. and Lima, C.D. and Steffan, J.S. and Thompson, L.M.
Cell Reports 4 (2): 362-375. 25 July 2013

Aggregation of polyQ-extended proteins is promoted by interaction with their natural coiled-coil partners.
Petrakis, S. and Schaefer, M.H. and Wanker, E.E. and Andrade-Navarro, M.A.
BioEssays 35 (6): 503-507. June 2013

In vivo phosphorylation and in vitro autophosphorylation-inactivation of Kluyveromyces lactis hexokinase KlHxk1.
Kettner, K. and Kuettner, E.B. and Otto, A. and Lilie, H. and Golbik, R.P. and Straeter, N. and Kriegel, T.M.
Biochemical and Biophysical Research Communications 435 (2): 313-318. 31 May 2013

A Y2H-seq approach defines the human protein methyltransferase interactome.
Weimann, M. and Grossmann, A. and Woodsmith, J. and Özkan, Z. and Birth, P. and Meierhofer, D. and Benlasfer, N. and Valovka, T. and Timmermann, B. and Wanker, E.E. and Sauer, S. and Stelzl, U.
Nature Methods 10 (4): 339-342. April 2013

Dynamic circadian protein-protein interaction networks predict temporal organization of cellular functions.
Wallach, T and Schellenberg, K and Maier, B and Kalathur, R.K. and Porras, P. and Wanker, E.E. and Futschik, M.E. and Kramer, A.
PLoS Genetics 9 (3): e1003398. March 2013

Translation of HTT mRNA with expanded CAG repeats is regulated by the MID1-PP2A protein complex.
Krauss, S. and Griesche, N. and Jastrzebska, E. and Chen, C. and Rutschow, D. and Achmüller, C. and Dorn, S. and Boesch, S.M. and Lalowski, M. and Wanker, E. and Schneider, R. and Schweiger, S.
Nature Communications 4 : 1511. 26 February 2013

Epigallocatechin-3-gallate: a useful, effective and safe clinical approach for targeted prevention and individualised treatment of neurological diseases.
Mähler, A. and Mandel, S. and Lorenz, M. and Ruegg, U. and Wanker, E.E. and Boschmann, M. and Paul, F.
EPMA Journal 4 (1): 5. 18 February 2013

Inhibitors of amyloid and oligomer formation.
Lorenzen, N. and Wanker, E.E. and Otzen, D.
In: Amyloid Fibrils and Prefibrillar Aggregates: Molecular and Biological Properties. Wiley-VCH (Germany), Weinheim, 345-372. ISBN 978-3-527-33200-7 12 February 2013

Development and application of a DNA microarray-based yeast two-hybrid system.
Suter, B. and Fontaine, J.F. and Yildirimman, R. and Raskó, T. and Schaefer, M.H. and Rasche, A. and Porras, P. and Vázquez-Álvarez, B.M. and Russ, J. and Rau, K. and Foulle, R. and Zenkner, M. and Saar, K. and Herwig, R. and Andrade-Navarro, M.A. and Wanker, E.E.
Nucleic Acids Research 41 (3): 1496-507. 1 February 2013

A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiple polyglutamine diseases.
Fujita, K. and Nakamura, Y. and Oka, T. and Ito, H. and Tamura, T. and Tagawa, K. and Sasabe, T. and Katsuta, A. and Motoki, K. and Shiwaku, H. and Sone, M. and Yoshida, C. and Katsuno, M. and Eishi, Y. and Murata, M. and Taylor, J.P. and Wanker, E.E. and Kono, K. and Tashiro, S. and Sobue, G. and La Spada, A.R. and Okazawa, H.
Nature Communications 4 : 1816. 2013

2012

Green tea halts progression of cardiac transthyretin amyloidosis: an observational report.
Kristen, A.V. and Lehrke, S. and Buss, S. and Mereles, D. and Steen, H. and Ehlermann, P. and Hardt, S. and Giannitsis, E. and Schreiner, R. and Haberkorn, U. and Schnabel, P.A. and Linke, R.P. and Roecken, C. and Wanker, E.E. and Dengler, T.J. and Altland, K. and Katus, H.A.
Clinical Research in Cardiology 101 (10): 805-813. October 2012

Structural properties of EGCG-induced, nontoxic Alzheimer's disease Aβ oligomers.
Lopez Del Amo, J.M. and Fink, U. and Dasari, M. and Grelle, G. and Wanker, E.E. and Bieschke, J. and Reif, B.
Journal of Molecular Biology 421 (4-5): 517-524. 24 August 2012

Identification of human proteins that modify misfolding and proteotoxicity of pathogenic ataxin-1.
Petrakis, S. and Rasko, T. and Russ, J. and Friedrich, R.P. and Stroedicke, M. and Riechers, S.P. and Muehlenberg, K. and Moeller, A. and Reinhardt, A. and Vinayagam, A. and Schaefer, M.H. and Boutros, M. and Tricoire, H. and Andrade-Navarro, M.A. and Wanker, E.E.
PLoS Genetics 8 (8): e1002897. 16 August 2012

Ahnak1 interaction is affected by phosphorylation of Ser-296 on Cavβ(2).
Pankonien, I. and Otto, A. and Dascal, N. and Morano, I. and Haase, H.
Biochemical and Biophysical Research Communications 421 (2): 184-189. 4 May 2012

Evolution and function of CAG/polyglutamine repeats in protein-protein interaction networks.
Schaefer, M.H. and Wanker, E.E. and Andrade-Navarro, M.A.
Nucleic Acids Research 40 (10): 4273-4287. 1 May 2012

Phosphorylation-regulated axonal dependent transport of syntaxin 1 is mediated by a Kinesin-1 adapter.
Chua, J.J.E. and Butkevich, E. and Worseck, J.M. and Kittelmann, M. and Gronborg, M. and Behrmann, E. and Stelzl, U. and Pavlos, N.J. and Lalowski, M.M. and Eimer, S. and Wanker, E.E. and Klopfenstein, D.R. and Jahn, R.
Proceedings of the National Academy of Sciences of the United States of America 109 (15): 5862-5867. 10 April 2012

The SNF2-like helicase HELLS mediates E2F3-dependent transcription and cellular transformation.
von Eyss, B. and Maaskola, J. and Memczak, S. and Möllmann, K. and Schuetz, A. and Loddenkemper, C. and Tanh, M.D. and Otto, A. and Muegge, K. and Heinemann, U. and Rajewsky, N. and Ziebold, U.
EMBO Journal 31 (4): 972-985. 15 February 2012

HIPPIE: integrating protein interaction networks with experiment based quality scores.
Schaefer, M.H. and Fontaine, J.F. and Vinayagam, A. and Porras, P. and Wanker, E.E. and Andrade-Navarro, M.A.
PLoS ONE 7 (2): e31826. 14 February 2012

670 nm laser light and EGCG complementarily reduce amyloid-β aggregates in human neuroblastoma cells: basis for treatment of Alzheimer's disease?
Sommer, A.P. and Bieschke, J. and Friedrich, R.P. and Zhu, D. and Wanker, E.E. and Fecht, H.J. and Mereles, D. and Hunstein, W.
Photomedicine and Laser Surgery 30 (1): 54-60. 4 January 2012

Small-molecule conversion of toxic oligomers to nontoxic β-sheet-rich amyloid fibrils.
Bieschke, J. and Herbst, M. and Wiglenda, T. and Friedrich, R.P. and Boeddrich, A. and Schiele, F. and Kleckers, D. and Lopez Del Amo, J.M. and Gruening, B.A. and Wang, Q. and Schmidt, M.R. and Lurz, R. and Anwyl, R. and Schnoegl, S. and Faendrich, M. and Frank, R.F. and Reif, B. and Guenther, S. and Walsh, D.M. and Wanker, E.E.
Nature Chemical Biology 8 (1): 93-101. January 2012

The investigation of binary PPIs with the classical yeast two-hybrid (Y2H) approach, Y2H variants, and other in vivo methods for PPI mapping.
Suter, B. and Wanker, E.E.
Methods in Molecular Biology 812 : v-vi. 2012

2011

The X-chromosome linked intellectual disability protein PQBP1 is a component of neuronal RNA granules and regulates the appearance of stress granules.
Kunde, S.A. and Musante, L. and Grimme, A. and Fischer, U. and Mueller, E. and Wanker, E.E. and Kalscheuer, V.M.
Human Molecular Genetics 20 (24): 4916-4931. 15 December 2011

Black tea theaflavins inhibit formation of toxic amyloid-beta and alpha-synuclein fibrils.
Grelle, G. and Otto, A. and Lorenz, M. and Frank, R.F. and Wanker, E.E. and Bieschke, J.
Biochemistry 50 (49): 10624-10636. 13 December 2011

A novel multiplex cell viability assay for high-throughput RNAi screening.
Gilbert, D.F. and Erdmann, G. and Zhang, X. and Fritzsche, A. and Demir, K. and Jaedicke, A. and Muehlenberg, K. and Wanker, E.E. and Boutros, M.
PLoS ONE 6 (12): e28338. 5 December 2011

Hemolytic porcine intestinal Escherichia coli without virulence-associated genes typical of intestinal pathogenic E. coli.
Schierack, P. and Weinreich, J. and Ewers, C. and Tachu, B. and Nicholson, B. and Barth, S.
Applied and Environmental Microbiology 77 (23): 8451-8455. December 2011

Ku70 alleviates neurodegeneration in drosophila models of Huntington's disease.
Tamura, T. and Sone, M. and Iwatsubo, T. and Tagawa, K. and Wanker, E.E. and Okazawa, H.
PLoS ONE 6 (11): e27408. 7 November 2011

A directed protein interaction network for investigating intracellular signal transduction.
Vinayagam, A. and Stelzl, U. and Foulle, R. and Plassmann, S. and Zenkner, M. and Timm, J. and Assmus, H.E. and Andrade-Navarro, M.A. and Wanker, E.E.
Science Signaling 4 (189): rs8. 6 September 2011

Detection of mutations by flow cytometric melting point analysis of PCR products.
Imre, L. and Balogh, I. and Kappelmayer, J. and Szabo, M. and Melegh, B. and Wanker, E. and Szabo, G.
Cytometry Part A 79A (9): 720-726. September 2011

PTAA and B10: new approaches to amyloid detection in tissue-evaluation of amyloid detection in tissue with a conjugated polyelectrolyte and a fibril-specific antibody fragment.
Kieninger, B. and Gioeva, Z. and Krueger, S. and Westermark, G.T. and Friedrich, R.P. and Faendrich, M. and Roecken, C.
Amyloid 18 (2): 47-52. June 2011

E. coli Nissle 1917 Affects Salmonella Adhesion to Porcine Intestinal Epithelial Cells.
Schierack, P. and Kleta, S. and Tedin, K. and Babila, J.T. and Oswald, S. and Oelschlaeger, T.A. and Hiemann, R. and Paetzold, S. and Wieler, L.H.
PLoS ONE 6 (2): e14712. 17 February 2011

Bacterial inclusion bodies of Alzheimer's disease beta-amyloid peptides can be employed to study native-like aggregation intermediate states.
Dasari, M. and Espargaro, A. and Sabate, R. and Lopez Del Amo, J.M. and Fink, U. and Grelle, G. and Bieschke, J. and Ventura, S. and Reif, B.
Chembiochem 12 (3): 407-423. 11 February 2011

Yeast hexokinase isoenzyme ScHxk2: stability of a two-domain protein with discontinuous domains.
Lilie, H. and Baer, D. and Kettner, K. and Weininger, U. and Balbach, J. and Naumann, M. and Mueller, E.C. and Otto, A. and Gast, K. and Golbik, R. and Kriegel, T.
Protein Engineering Design and Selection 24 (1-2): 79-87. January 2011

2010

Crystal structure of hexokinase KlHxk1 of Kluyveromyces lactis: a molecular basis for understanding the control of yeast hexokinase functions via covalent modification and oligomerization.
Kuettner, E.B. and Kettner, K. and Keim, A. and Svergun, D.I. and Volke, D. and Singer, D. and Hoffmann, R. and Mueller, E.C. and Otto, A. and Kriegel, T.M. and Straeter, N.
Journal of Biological Chemistry 285 (52): 41019-41033. 24 December 2010

Gruener Tee - neue Einsichten fuer einen alten Wirkstoff [Green tea - new insights for an old drug].
Bieschke, J.
Chemie in unserer Zeit 44 (4): 306-307. August 2010

Inferring modules from human protein interactome classes.
Marras, E. and Travaglione, A. and Chaurasia, G. and Futschik, M. and Capobianco, E.
BMC Systems Biology 4 : 105. 23 July 2010

Mutant huntingtin impairs Ku70-mediated DNA repair.
Enokido, Y. and Tamura, T. and Ito, H. and Arumughan, A. and Komuro, A. and Shiwaku, H. and Sone, M. and Foulle, R. and Sawada, H. and Ishiguro, H. and Ono, T. and Murata, M. and Kanazawa, I. and Tomilin, N. and Tagawa, K. and Wanker, E.E. and Okazawa, H.
Journal of Cell Biology 189 (3): 425-443. 3 May 2010

EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity.
Bieschke, J. and Russ, J. and Friedrich, R.P. and Ehrnhoefer, D.E. and Wobst, H. and Neugebauer, K. and Wanker, E.E.
Proceedings of the National Academy of Sciences of the United States of America 107 (17): 7710-7715. 27 April 2010

Structure and function of yeast glutaredoxin 2 depend on postranslational processing and are related to subcellular distribution.
Porras, P. and McDonagh, B. and Pedrajas, J.R. and Barcena, J.A. and Padilla, C.A.
Biochimica et Biophysica Acta - Proteins and Proteomics 1804 (4): 839-845. April 2010

Pathogenic polyglutamine tracts are potent inducers of spontaneous sup35 and rnq1 amyloidogenesis.
Goehler, H. and Droege, A. and Lurz, R. and Schnoegl, S. and Chernoff, Y.O. and Wanker, E.E.
PLoS ONE 5 (3): e9642. 10 March 2010

Repeated two-hybrid screening detects transient protein-protein interactions.
Vinayagam, A. and Stelzl, U. and Wanker, E.E.
Theoretical Chemistry Accounts 125 (3-6): 613-619. March 2010

The coxsackievirus-adenovirus receptor reveals complex homophilic and heterophilic interactions on neural cells.
Patzke, C. and Max, K.E. and Behlke, J. and Schreiber, J. and Schmidt, H. and Dorner, A.A. and Kroeger, S. and Henning, M. and Otto, A. and Heinemann, U. and Rathjen, F.G.
Journal of Neuroscience 30 (8): 2897-2910. 24 February 2010

2009

Polyglutamine expansion in huntingtin increases its insertion into lipid bilayers.
Kegel, K.B. and Schewkunow, V. and Sapp, E. and Masso, N. and Wanker, E.E. and Difiglia, M. and Goldmann, W.H.
Biochemical and Biophysical Research Communications 387 (3): 472-475. 25 September 2009

Novel roles of Hakai in cell proliferation and oncogenesis.
Figueroa, A. and Kotani, H. and Toda, Y. and Mazan-Mamczarz, K. and Mueller, E.C. and Otto, A. and Disch, L. and Norman, M. and Ramdasi, R. and Keshtgar, M. and Gorospe, M. and Fujita, Y.
Molecular Biology of the Cell 20 (15): 3533-3542. August 2009

Evaluation of the possible transmission of BSE and scrapie to gilthead sea bream (Sparus aurata).
Salta, E. and Panagiotidis, C. and Teliousis, K. and Petrakis, S. and Eleftheriadis, E. and Arapoglou, F. and Grigoriadis, N. and Nicolaou, A. and Kaldrymidou, E. and Krey, G. and Sklaviadis, T.
PLoS ONE 4 (7): e6175. 28 July 2009

Detection of alpha-rod protein repeats using a neural network and application to huntingtin.
Palidwor, G.A. and Shcherbinin, S. and Huska, M.R. and Rasko, T. and Stelzl, U. and Arumughan, A. and Foulle, R. and Porras, P. and Sanchez-Pulido, L. and Wanker, E.E. and Andrade-Navarro, M.A.
PLoS Computational Biology 5 (3): e1000304. 13 March 2009

Transferrin-receptor-mediated iron accumulation controls proliferation and glutamate release in glioma cells.
Chirasani, S.R. and Markovic, D.S. and Synowitz, M. and Eichler, S.A. and Wisniewski, P. and Kaminska, B. and Otto, A. and Wanker, E. and Schaefer, M. and Chiarugi, P. and Meier, J.C. and Kettenmann, H. and Glass, R.
Journal of Molecular Medicine 87 (2): 153-167. February 2009

Glial cell lineage expression of mutant ataxin-1 and huntingtin induces developmental and late-onset neuronal pathologies in drosophila models.
Tamura, T. and Sone, M. and Yamashita, M. and Wanker, E.E. and Okazawa, H.
PLoS ONE 4 (1): e4262. 23 January 2009

An empirical framework for binary interactome mapping.
Venkatesan, K. and Rual, J.F. and Vazquez, A. and Stelzl, U. and Lemmens, I. and Hirozane-Kishikawa, T. and Hao, T. and Zenkner, M. and Xin, X. and Goh, K.I. and Yildirim, M.A. and Simonis, N. and Heinzmann, K. and Gebreab, F. and Sahalie, J.M. and Cevik, S. and Simon, C. and de Smet, A.S. and Dann, E. and Smolyar, A. and Vinayagam, A. and Yu, H. and Szeto, D. and Borick, H. and Dricot, A. and Klitgord, N. and Murray, R.R. and Lin, C. and Lalowski, M. and Timm, J. and Rau, K. and Boone, C. and Braun, P. and Cusick, M.E. and Roth, F.P. and Hill, D.E. and Tavernier, J. and Wanker, E.E. and Barabasi, A.L. and Vidal, M.
Nature Methods 6 (1): 83-90. January 2009

Cleft lip and/or palate with monogenic autosomal recessive transmission in Pyrenees shepherd dogs.
Kemp, C. and Thiele, H. and Dankof, A. and Schmidt, G. and Lauster, C. and Fernahl, G. and Lauster, R.
Cleft Palate-Craniofacial Journal 46 (1): 81-88. January 2009

UniHI 4: new tools for query, analysis and visualization of the human protein-protein interactome.
Chaurasia, G. and Malhotra, S. and Russ, J. and Schnoegl, S. and Haenig, C. and Wanker, E.E. and Futschik, M.E.
Nucleic Acids Research 37 (Database Issue): D657-D660. January 2009

2008

A fluorescent two-hybrid (F2H) assay for direct visualization of protein interactions in living cells.
Zolghadr, K. and Mortusewicz, O. and Rothbauer, U. and Kleinhans, R. and Goehler, H. and Wanker, E.E. and Cardoso, M.C. and Leonhardt, H.
Molecular and Cellular Proteomics 7 (11): 2279-2287. 1 November 2008

Bell's palsy: combined treatment of famciclovir and prednisone is superior to prednisone alone.
Minnerop, M. and Herbst, M. and Fimmers, R. and Matz, B. and Klockgether, T. and Wuellner, U.
Journal of Neurology 255 (11): 1726-1730. November 2008

Identification and characterization of CaApe2 – a neutral arginine/alanine/leucine-specific metallo-aminopeptidase from Candida albicans.
Klinke, T. and Rump, A. and Poenisch, R. and Schellenberger, W. and Mueller, E.C. and Otto, A. and Klimm, W. and Kriegel, T.M.
FEMS Yeast Research 8 (6): 858-869. September 2008

Comparative 3'UTR analysis allows identification of regulatory clusters that drive Eph/ephrin expression in cancer cell lines.
Winter, J. and Roepcke, S. and Krause, S. and Mueller, E.C. and Otto, A. and Vingron, M. and Schweiger, S.
PLoS ONE 3 (7): e2780. 23 July 2008

Omi / HtrA2 is relevant to the selective vulnerability of striatal neurons in Huntington's disease.
Inagaki, R. and Tagawa, K. and Qi, M.L. and Enokido, Y. and Ito, H. and Tamura, T. and Shimizu, S. and Oyanagi, K. and Arai, N. and Kanazawa, I. and Wanker, E.E. and Okazawa, H.
European Journal of Neuroscience 28 (1): 30-40. July 2008

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers.
Ehrnhoefer, D.E. and Bieschke, J. and Boeddrich, A. and Herbst, M. and Masino, L. and Lurz, R. and Engemann, S. and Pastore, A. and Wanker, E.E.
Nature Structural & Molecular Biology 15 (6): 558-566. June 2008

Therapy effects of green tea in a patient with systemic light-chain amyloidosis.
Mereles, D. and Wanker, E.E. and Katus, H.A.
Clinical Research in Cardiology 97 (5): 341-344. May 2008

The Opitz syndrome gene product MID1 assembles a microtubule-associated ribonucleoprotein complex.
Aranda-Orgilles, B. and Trockenbacher, A. and Winter, J. and Aigner, J. and Koehler, A. and Jastrzebska, E. and Stahl, J. and Mueller, E.C. and Otto, A. and Wanker, E.E. and Schneider, R. and Schweiger, S.
Human Genetics 123 (2): 163-176. March 2008

Alpha-synuclein selectively binds to anionic phospholipids embedded in liquid-disordered domains.
Stoeckl, M. and Fischer, P. and Wanker, E.E. and Herrmann, A.
Journal of Molecular Biology 375 (5): 1394-1404. 1 February 2008

Structure-function analysis of the filamentous actin binding domain of the neuronal scaffolding protein spinophilin.
Schueler, H. and Peti, W.
FEBS Journal 275 (1): 59-68. January 2008

Actin/myosin-based gliding motility in apicomplexan parasites.
Matuschewski, K. and Schueler, H.
Subcellular Biochemistry 47 (47): 110-120. 2008

2007

Identification and characterization of a novel glucose-phosphorylating enzyme in Kluyveromyces lactis.
Kettner, K. and Mueller, E.C. and Otto, A. and Roedel, G. and Breunig, K.D. and Kriegel, T.M.
FEMS Yeast Research 7 (5): 683-692. August 2007

Small molecule inducers of heat-shock response reduce polyQ-mediated huntingtin aggregation. A possible therapeutic strategy.
Herbst, M. and Wanker, E.E.
Neurodegenerative Diseases 4 (2-3): 254-260. June 2007

Proteome analysis of soluble nuclear proteins reveals that HMGB1/2 suppress genotoxic stress in polyglutamine diseases.
Qi, M.L. and Tagawa, K. and Enokido, Y. and Yoshimura, N. and Wada, Y.I. and Watase, K. and Ishiura, S.I. and Kanazawa, I. and Botas, J. and Saitoe, M. and Wanker, E.E. and Okazawa, H.
Nature Cell Biology 9 (4): 402-414. April 2007

Comparison of human protein-protein interaction maps.
Futschik, M.E. and Chaurasia, G. and Herzel, H.
Bioinformatics 23 (5): 605-611. March 2007

Flexible web-based integration of distributed large-scale human protein interaction maps.
Chaurasia, G. and Iqbal, Y. and Haenig, C. and Herzel, H. and Wanker, E.E. and Futschik, M.E.
Journal of Integrative Bioinformatics 4 (1): 51. 26 February 2007

Crystal structure of human inosine triphosphatase: Substrate binding and implication of the itpa deficiency mutation p32T.
Stenmark, P. and Kursula, P. and Flodin, S. and Graeslund, S. and Landry, R. and Nordlund, P. and Schueler, H.
Journal of Biological Chemistry 282 (5): 3182-3187. 2 February 2007

Pathological consequences of VCP mutations on human striated muscle.
Huebbers, C.U. and Clemen, C.S. and Kesper, K. and Boeddrich, A. and Hofmann, A. and Kaemaeraeinen, O. and Tolksdorf, K. and Stumpf, M. and Reichelt, J. and Roth, U. and Krause, S. and Watts, G. and Kimonis, V. and Wattjes, M.P. and Reimann, J. and Thal, D.R. and Biermann, K. and Evert, B.O. and Lochmueller, H. and Wanker, E.E. and Schoser, B.G. and Noegel, A.A. and Schroeder, R.
Brain 130 (2): 381-393. 1 February 2007

The induction levels of heat shock protein 70 differentiate the vulnerabilities to mutant huntingtin among neuronal subtypes.
Tagawa, K. and Marubuchi, S. and Qi, M.L. and Enokido, Y. and Tamura, T. and Inagaki, R. and Murata, M. and Kanazawa, I. and Wanker, E.E. and Okazawa, H.
Journal of Neuroscience 27 (4): 868-880. 24 January 2007

Self-association of adrenodoxin studied by using analytical ultracentrifugation.
Behlke, J. and Ristau, O. and Mueller, E.C. and Hannemann, F. and Bernhardt, R.
Biophysical Chemistry 125 (1): 159-165. January 2007

UniHI: an entry gate to the human protein interactome.
Chaurasia, G. and Iqbal, Y. and Haenig, C. and Herzel, H. and Wanker, E.E. and Futschik, M.E.
Nucleic Acids Research 35 (Database Issue): D590-D594. January 2007

2006

The collapsin response mediator protein 1 (CRMP-1) and the promyelocytic leukemia zinc finger protein (PLZF) bind to UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE), the key enzyme of sialic acid biosynthesis.
Weidemann, W. and Stelzl, U. and Lisewski, U. and Bork, K. and Wanker, E.E. and Hinderlich, S. and Horstkorte, R.
FEBS Letters 580 (28): 6649-6654. 11 December 2006

The value of high quality protein-protein interaction networks for systems biology.
Stelzl, U. and Wanker, E.E.
Current Opinion in Chemical Biology 10 (6): 551-558. December 2006

Plant nitric oxide synthase: a never-ending story?
Zemojtel, T. and Froehlich, A. and Palmieri, M.C. and Kolanczyk, M. and Mikula, I. and Wyrwicz, L.S. and Wanker, E.E. and Mundlos, S. and Vingron, M. and Martasek, P. and Durner, J.
Trends Plant Sci 11 (11): 524-525. November 2006

Regulation of apicomplexan microfilament dynamics by a minimal set of actin-binding proteins.
Schueler, H. and Matuschewski, K.
Traffic 7 (11): 1433-1439. November 2006

Novel drugs and diagnostic compositions for use in the treatment and diagnosis of neurodegenerative diseases or amyloid diseases [Neue Arzneimittel und diagnostische Zusammensetzungen fuer die Behandlung und Diagnose von neurodegenerativen Erkrankungen und Amyloid-Krankheiten].
Wanker, E.E. and Engemann, S. and Rautenberg, S. and Boeddrich, A. and Harjes, P. and Litscher, D. and Herbst, M. and Walther, J.
EP1713457 ; WO0577343. 25 October 2006

Analytical model of peptide mass cluster centres with applications.
Wolski, W.E. and Farrow, M. and Emde, A.K. and Lehrach, H. and Lalowski, M. and Reinert, K.
Proteome Science 4 : 18. 23 September 2006

Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models.
Ehrnhoefer, D.E. and Duennwald, M. and Markovic, P. and Wacker, J.L. and Engemann, S. and Roark, M. and Legleiter, J. and Marsh, J.L. and Thompson, L.M. and Lindquist, S. and Muchowski, P.J. and Wanker, E.E.
Human Molecular Genetics 15 (18): 2743-2751. 15 September 2006

Potassium channel dysfunction and depolarized resting membrane potential in a cell model of SCA3.
Jeub, M. and Herbst, M. and Spauschus, A. and Fleischer, H. and Klockgether, T. and Wuellner, U. and Evert, B.O.
Exp Neurol 201 (1): 182-192. 1 September 2006

Huntingtin interacts with the receptor sorting family protein GASP2.
Horn, S.C. and Lalowski, M. and Goehler, H. and Droege, A. and Wanker, E.E. and Stelzl, U.
Journal of Neural Transmission 113 (8): 1081-1090. August 2006

Method for the identification of protein-protein interactions in disease related protein networks [Verfahren zur Identifizierung von Protein-Protein-Wechselwirkungen in krankheitsbezogenen Proteinnetzwerken].
Wanker, E.E. and Lalowski, M. and Stelzl, U. and Stroedicke, M. and Haenig, C. and Worm, U. and Goehler, H.
EP1677113. 5 July 2006

Structure of the synthetase domain of human CTP synthetase, a target for anticancer therapy.
Kursula, P. and Flodin, S. and Ehn, M. and Hammarstroem, M. and Schueler, H. and Nordlund, P. and Stenmark, P.
Acta Crystallographica Section F 62 (7): 613-617. 1 July 2006

Genomic analysis of Xenopus organizer function.
Hufton, A.L. and Vinayagam, A. and Suhai, S. and Baker, J.C.
BMC Developmental Biology 6 : 27. 6 June 2006

Complexes of syndapin II with dynamin II promote vesicle formation at the trans-Golgi network.
Kessels, M.M. and Dong, J. and Leibig, W. and Westermann, P. and Qualmann, B.
Journal of Cell Science 119 (8): 1504-1516. 15 April 2006

An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis.
Boeddrich, A. and Gaumer, S. and Haacke, A. and Tzvetkov, N. and Albrecht, M. and Evert, B.O. and Mueller, E.C. and Lurz, R. and Breuer, P. and Schugardt, N. and Plassmann, S. and Xu, K. and Warrick, J.M. and Suopanki, J. and Wuellner, U. and Frank, R. and Hartl, U.F. and Bonini, N.M. and Wanker, E.E.
EMBO Journal 25 (7): 1547-1558. 5 April 2006

Plasmodium motility: actin not actin' like actin.
Schueler, H. and Matuschewski, K.
Trends in Parasitology 22 (4): 146-147. April 2006

Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73.
Hoshino, M. and Qi, M.L. and Yoshimura, N. and Miyashita, T. and Tagawa, K. and Wada, Y.I. and Enokido, Y. and Marubuchi, S. and Arai, P. and Arai, N. and Oyanagi, K. and Blandino, G. and Sudol, M. and Rich, T. and Kanazawa, I. and Wanker, E.E. and Saitoe, M. and Okazawa, H.
Journal of Cell Biology 172 (4): 589-604. 13 February 2006

Identification of VCP/p97, CHIP and amphiphysin II interaction partners using membrane-based human proteome arrays.
Grelle, G. and Kostka, S. and Otto, A. and Kersten, B. and Genser, K.F. and Mueller, E.C. and Waelter, S. and Boeddrich, A. and Stelzl, U. and Haenig, C. and Volkmer-Engert, R. and Landgraf, C. and Alberti, S. and Hoehfeld, J. and Stroedicke, M. and Wanker, E.E.
Molecular & Cellular Proteomics 5 (2): 234-244. 1 February 2006

Interaction of huntingtin fragments with brain membranes - clues to early dysfunction in Huntington's disease.
Suopanki, J. and Goetz, C. and Lutsch, G. and Schiller, J. and Harjes, P. and Herrmann, A. and Wanker, E.E.
Journal of Neurochemistry 96 (3): 870-884. February 2006

Low stability of huntington muscle mitochondria against Ca2+ in R6/2 mice.
Gizatullina, Z.Z. and Lindenberg, K.S. and Harjes, P. and Chen, Y. and Kosinski, C.M. and Landwehrmeyer, B.G. and Ludolph, A.C. and Striggow, F. and Zierz, S. and Gellerich, F.N.
Annals of Neurology 59 (2): 407-411. February 2006

Evaluation of the benzothiazole aggregation inhibitors riluzole and PGL-135 as therapeutics for Huntington's disease.
Hockly, E. and Tse, J. and Barker, A.L. and Moolman, D.L. and Beunard, J.L. and Revington, A.P. and Holt, K. and Sunshine, S. and Moffitt, H. and Sathasivam, K. and Woodman, B. and Wanker, E.E. and Lowden, P.A. and Bates, G.P.
Neurobiology of Disease 21 (1): 228-236. January 2006

Protein-Wechselwirkungsnetzwerke: Aufklaerung der Funktion von Proteinen.
Stelzl, U. and Wanker, E.E.
Biologie in unserer Zeit 36 (1): 12-13. January 2006

Mass spectrometry: ESI.
Mueller, E.C.
In: Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine ; Vol. 2. Springer, Berlin [u.a.], 1020-1022. ISBN 3-540-44244-8 2006

Recombinant protein production in mammalian cell culture.
Droege, A.
In: Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine ; Vol. 2. Springer, Berlin [u.a.], 1616-1620. ISBN 3-540-44244-8 2006

Systematic functional assessment of human protein-protein interaction maps.
Chaurasia, G. and Herzel, H. and Wanker, E.E. and Futschik, M.E.
Genome Inform 17 : 36-45. 2006

The connection between actin ATPase and polymerization.
Schueler, H. and Karlsson, R. and Schutt, C.E. and Lindberg, U.
Advances in Molecular and Cell Biology 37 : 49-66. 2006

Therapeutic approaches to polyglutamine diseases: combating protein misfolding and aggregation.
Herbst, M. and Wanker, E.E.
Current Pharmaceutical Design 12 (20): 2543-2555. 2006

2005

Transformation and other factors of the peptide mass spectrometry pairwise peak-list comparison process.
Wolski, W.E. and Lalowski, M. and Martus, P. and Herwig, R. and Giavalisco, P. and Gobom, J. and Sickmann, A. and Lehrach, H. and Reinert, K.
BMC Bioinformatics 6 : 285. 30 November 2005

Method for qualitative comparisons of protein mixtures based on enzyme-catalyzed stable-isotope incorporation.
Mirgorodskaya, E. and Wanker, E.E. and Otto, A. and Lehrach, H. and Gobom, J.
Journal of Proteome Research 4 (6): 2109-2116. 1 November 2005

Molecular analysis of the interaction between cardosin A and phospholipase Dalpha.
Simoes, I. and Mueller, E.C. and Otto, A. and Bur, D. and Cheung, A.Y. and Faro, C. and Pires, E.
FEBS Journal 272 (22): 5786-5798. 1 November 2005

A human protein-protein interaction network: a resource for annotating the proteome.
Stelzl, U. and Worm, U. and Lalowski, M. and Haenig, C. and Brembeck, F.H. and Goehler, H. and Stroedicke, M. and Zenkner, M. and Schoenherr, A. and Koeppen, S. and Timm, J. and Mintzlaff, S. and Abraham, C. and Bock, N. and Kietzmann, S. and Goedde, A. and Toksoez, E. and Droege, A. and Krobitsch, S. and Korn, B. and Birchmeier, W. and Lehrach, H. and Wanker, E.E.
Cell 122 (6): 957-968. 23 September 2005

Ataxin-2 and huntingtin interact with endophilin-A complexes to function in plastin-associated pathways.
Ralser, M. and Nonhoff, U. and Albrecht, M. and Lengauer, T. and Wanker, E.E. and Lehrach, H. and Krobitsch, S.
Human Molecular Genetics 14 (19): 2893-2909. 22 August 2005

Calibration of mass spectrometric peptide mass fingerprint data without specific external or internal calibrants.
Wolski, W.E. and Lalowski, M. and Jungblut, P. and Reinert, K.
BMC Bioinformatics 6 : 203. 15 August 2005

Generation of a yeast two-hybrid strain suitable for competitive protein binding analysis.
Ralser, M. and Goehler, H. and Wanker, E.E. and Lehrach, H. and Krobitsch, S.
Biotechniques 39 (2): 165-168. 1 August 2005

Multiplex approaches in protein microarray technology.
Kersten, B. and Wanker, E.E. and Hoheisel, J.D. and Angenendt, P.
Expert Review of Proteomics 2 (4): 499-510. 1 August 2005

Parkin interacts with the proteasome subunit alpha4.
Daechsel, J.C. and Luecking, C.B. and Deeg, S. and Schultz, E. and Lalowski, M. and Casademunt, E. and Corti, O. and Hampe, C. and Patenge, N. and Vaupel, K. and Yamamoto, A. and Dichgans, M. and Brice, A. and Wanker, E.E. and Kahle, P.J. and Gasser, T.
FEBS Letters 579 (18): 3913-3919. 18 July 2005

High-throughput identification of potential Arabidopsis MAP kinases substrates.
Feilner, T. and Hultschig, C. and Lee, J. and Meyer, S. and Immink, R.G. and Koenig, A. and Possling, A. and Seitz, H. and Beveridge, A. and Scheel, D. and Cahill, D.J. and Lehrach, H. and Kreutzberger, J. and Kersten, B.
Molecular & Cellular Proteomics 4 (10): 1558-1568. 11 July 2005

Nuclear oncoprotein prothymosin alpha is a partner of Keap1: implications for expression of oxidative stress-protecting genes.
Karapetian, R.N. and Evstafieva, A.G. and Abaeva, I.S. and Chichkova, N.V. and Filonov, G.S. and Rubtsov, Y.P. and Sukhacheva, E.A. and Melnikov, S.V. and Schneider, U. and Wanker, E.E. and Vartapetian, A.B.
Molecular and Cellular Biology 25 (3): 1089-1099. 1 February 2005

A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo.
Zhang, X. and Smith, D.L. and Meriin, A.B. and Engemann, S. and Russel, D.E. and Roark, M. and Washington, S.L. and Maxwell, M.M. and Marsh, J.L. and Thompson, L.M. and Wanker, E.E. and Young, A.B. and Housman, D.E. and Bates, G.P. and Sherman, M.Y. and Kazantsev, A.G.
Proceedings of the National Academy of Sciences of the United States of America 102 (3): 892-897. 18 January 2005

Cerebral embolism from left atrial myxoma leading to cerebral and retinal aneurysms: A case report.
Herbst, M. and Wattjes, M.P. and Urbach, H. and Inhetvin-Hutter, C. and Becker, D. and Kjockgether, T. and Hartmann, A.
American Journal of Neuroradiology 26 (3): 666-669. 1 January 2005

Characterization of mouse myotilin and its promoter.
Mologni, L. and Moza, M. and Lalowski, M.M. and Carpen, O.
Biochemical and Biophysical Research Communications 329 (3): 1001-1009. 1 January 2005

PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation.
Yu, M. and Schreek, S. and Cerni, C. and Schamberger, C. and Lesniewicz, K. and Poreba, E. and Vervoorts, J. and Walsemann, G. and Groetzinger, J. and Kremmer, E. and Mehraein, Y. and Mertsching, J. and Kraft, R. and Austen, M. and Luscher-Firzlaff, J. and Luescher, B.
Oncogene 24 (12): 1982-1993. 1 January 2005

Sulfur dehydrogenase of Paracoccus pantotrophus: The heme-2 domain of the molybdoprotein cytochrome c complex is dispensable for catalytic activity.
Bardischewsky, F. and Quentmeier, A. and Rother, D. and Hellwig, P. and Kostka, S. and Friedrich, C.G.
Biochemistry 44 (18): 7024-7034. 1 January 2005

2004

Disease related protein network [Proteinnetzwerk, das im Zusammenhang mit einer Krankheit steht].
Wanker, E.E. and Lehrach, H. and Goehler, H. and Stroedicke, M. and Stelzl, U. and Lalowski, M.
EP1636362 ; WO04113566. 29 December 2004

A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease.
Goehler, H. and Lalowski, M. and Stelzl, U. and Waelter, S. and Stroedicke, M. and Worm, U. and Droege, A. and Lindenberg, K.S. and Knoblich, M. and Haenig, C. and Herbst, M. and Suopanki, J. and Scherzinger, E. and Abraham, C. and Bauer, B. and Hasenbank, R. and Fritzsche, A. and Ludewig, A.H. and Buessow, K. and Coleman, S.H. and Gutekunst, C.A. and Landwehrmeyer, B.G. and Lehrach, H. and Wanker, E.E.
Molecular Cell 15 (6): 853-865. 24 September 2004

Domain specific characteristics of the bifunctional key enzyme of sialic acid biosynthesis, UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase.
Blume, A. and Weidemann, W. and Stelzl, U. and Wanker, E.E. and Lucka, L. and Donner, P. and Reutter, W. and Horstkorte, R. and Hinderlich, S.
Biochemical Journal 384 (3): 599-607. 26 August 2004

Huntingtin bodies sequester vesicle-associated proteins by a polyproline-dependent interaction.
Qin, Z.H. and Wang, Y. and Sapp, E. and Cuiffo, B. and Wanker, E. and Hayden, M.R. and Kegel, K.B. and Aronin, N. and DiFiglia, M.
Journal of Neuroscience 7 (1): 269-281. 7 January 2004

A molecular pathogenesis for transcription factor associated poly-alanine tract expansions.
Albrecht, A.N. and Kornak, U. and Boeddrich, A. and Suering, K. and Robinson, P.N. and Stiege, A.C. and Lurz, R. and Stricker, S. and Wanker, E.E. and Mundlos, S.
Human Molecular Genetics 13 (20): 2351-2359. 1 January 2004

Action and reaction: Chlamydophila pneumoniae proteome alteration in a persistent infection induced by iron deficiency.
Wehrl, W. and Meyer, T.F. and Jungblut, P.R. and Mueller, E.C. and Szczepek, A.J.
Proteomics 4 (10): 2969-2981. 1 January 2004

Biochemical and proteomic analysis of the magnetosome membrane in Magnetospitillum gryphiswaldense.
Gruenberg, K. and Mueller, E.C. and Otto, A. and Reszka, R. and Linder, D. and Kube, M. and Reinhardt, R. and Schueler, D.
Applied and Environmental Microbiology 70 (2): 1040-1050. 1 January 2004

CFP10 discriminates between nonacetylated and acetylated ESAT-6 of Mycobacterium tuberculosis by differential interaction.
Okkels, L.M. and Mueller, E.C. and Schmid, M. and Rosenkrands, I. and Kaufmann, S.H.E. and Andersen, P. and Jungblut, P.R.
Proteomics 4 (10): 2954-2960. 1 January 2004

Distinct aggregation and cell death patterns among different types of primary neurons induced by mutant huntingtin protein.
Tagawa, K. and Hoshino, M. and Okuda, T. and Ueda, H. and Hayashi, H. and Engemann, S. and Okado, H. and Ichikawa, M. and Wanker, E.E. and Okazawa, H.
Journal of Neurochemistry 89 (4): 974-987. 1 January 2004

Grossfahndung nach Hemmstoffen : Huntington-Forschung in Deutschland.
Schnoegl, S. and Wanker, E.E.
Spektrum der Wissenschaft 1 : 64-65. 1 January 2004

Molecular and physiological characterisation of a 3-phytase from soil bacterium Klebsiella sp. ASR1.
Sajidan, A. and Farouk, A. and Greiner, R. and Jungblut, P. and Mueller, E.C. and Borriss, R.
Applied Microbiology and Biotechnology 65 (1): 110-118. 1 January 2004

The adrenodoxin-like ferredoxin of Schizosaccharomyces pombe mitochondria.
Schiffler, B. and Bureik, M. and Reinle, W. and Mueller, E.C. and Hannemann, F. and Bernhardt, R.
Journal of Inorganic Biochemistry 98 (7): 1229-1237. 1 January 2004

The interaction of protein kinase C isozymes α, ι, and θ with the cytoplasmic domain of L-selectin is modulated by phosphorylation of the receptor.
Kilian, K. and Dernedde, J. and Mueller, E.C. and Bahr, I. and Tauber, R.
Journal of Biological Chemistry 279 (33): 34472-34480. 1 January 2004

Grossfahndung nach Hemmstoffen.
Wanker, E.E. and Schnoegl, S.
Spektrum der Wissenschaft (1): 64-65. January 2004

2003

Mutant huntingtin promotes the fibrillogenesis of wild-type huntingtin - A potential mechanism for loss of huntingtin function in Huntington's disease.
Busch, A. and Engemann, S. and Lurz, R. and Okazawa, H. and Lehrach, H. and Wanker, E.E.
Journal of Biological Chemistry 278 (42): 41452-41461. 17 October 2003

The unique hexokinase of Kluyveromyces lactis - Molecular and functional characterization and evaluation of a role in glucose signaling.
Baer, D. and Golbik, R. and Huebner, G. and Lilie, H. and Mueller, E.C. and Naumann, M. and Otto, A. and Reuter, R. and Breunig, K.D. and Kriegel, T.M.
Journal of Biological Chemistry 278 (41): 39280-39286. 10 October 2003

The hunt for huntingtin function: interaction partners tell many different stories.
Harjes, P. and Wanker, E.E.
Trends in Biochemical Sciences 28 (8): 425-433. August 2003

Proteomic and postproteomic characterization of keratan sulfate-glycanated isoforms of thyroglobulin and transferrin uniquely elaborated by papillary thyroid carcinomas.
Magro, G. and Perissinotto, D. and Schiappacassi, M. and Goletz, S. and Otto, A. and Mueller, E.C. and Bisceglia, M. and Brown, G. and Ellis, T. and Grasso, S. and Colombatti, A. and Perris, R.
American Journal of Pathology 163 (1): 183-196. July 2003

Essential role of the apolipoprotein E receptor-2 in sperm development.
Andersen, O.M. and Yeung, C.H. and Vorum, H. and Wellner, M. and Andreassen, T.K. and Erdmann, B. and Mueller, E.C. and Herz, J. and Otto, A. and Cooper, T.G. and Willnow, T.E.
Journal of Biological Chemistry 278 (26): 23989-23995. 27 June 2003

Verfahren zur Isolierung von Neuronen.
Pfrieger, F.W. and Naegler, K.
DE10155130A1. 22 May 2003

Mittel zur Behandlung von Laesionen des Nervensystems [Agents for treating lesions of the nervous system].
Pfrieger, F.W. and Mauch, D. and Goeritz, C. and Naegler, K.
DE10154221A1 ; EP1443941 ; WO0339555. 15 May 2003

Cloning, sequencing and recombinant expression of the open reading frame encoding a novel member of the Sarcocystis muris (Apicomplexa) microneme lectin family.
Klein, H. and Mueller, S. and Loeschner, B. and Toenjes, R.R. and Braun, G. and Mueller, E.C. and Otto, A. and Montag, T.
Parasitology Research 90 (1): 84-86. May 2003

Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing.
Odintsova, T.I. and Mueller, E.C. and Ivanov, A.V. and Egorov, T.A. and Bienert, R. and Vladimirov, S.N. and Kostka, S. and Otto, A. and Wittmann-Liebold, B. and Karpova, G.G.
Journal of Protein Chemistry 22 (3): 249-258. April 2003

Identification and characterization of the autophosphorylation sites of phosphoinositide 3-kinase isoforms beta and gamma.
Czupalla, C. and Culo, M. and Mueller, E.C. and Brock, C. and Reusch, H.P. and Spicher, K. and Krause, E. and Nuernberg, B.
Journal of Biological Chemistry 278 (13): 11536-11545. 28 March 2003

Neuron culture medium and use of cholesterol for cultivating, differentiating or proliferating neurons [Neues Medium zur Kultivierung von Nervenzellen].
Pfrieger, F.W. and Naegler, K.
DE10204747A1 ; WO0325160. 27 March 2003

Inhibitors of PolyQ-Aggregation [Hemmer der Aggregation von PolyQ].
Boettcher, H. and Herhaus, C. and Barnickel, G. and Wanker, E.E. and Heiser, V. and Lehrach, H. and Broeker, W. and Dunkel, I.
WO03015772 ; EP1416931. 27 February 2003

Affinity purification of ARE-binding proteins identifies polyA-binding protein 1 as a potential substrate in MK2-induced mRNA stabilization.
Bollig, F. and Winzen, R. and Gaestel, M. and Kostka, S. and Resch, K. and Holtmann, H.
Biochemical and Biophysical Research Communications 301 (3): 665-670. 14 February 2003

Polyglutamine fibrillogenesis: The pathway unfolds.
Ross, C.A. and Poirier, M.A. and Wanker, E.E. and Amzel, M.
Proceedings of the National Academy of Sciences of the United States of America 100 (1): 1-3. 7 January 2003

Comparative proteome analysis of culture supernatant proteins from virulent Mycobacterium tuberculosis H37Rv and attenuated M-bovis BCG Copenhagen.
Mattow, J. and Schaible, U.E. and Schmidt, F. and Hagens, K. and Siejak, R. and Brestrich, G. and Haeselbarth, G. and Mueller, E.C. and Jungblut, P.R. and Kaufmanni, S.H.E.
Electrophoresis 24 (19-20): 3405-3420. 1 January 2003

Histone deacetylase activity is retained in primary neurons expressing mutant huntingtin protein.
Hoshino, M. and Tagawa, K. and Okuda, T. and Murata, M. and Oyanagi, K. and Arai, N. and Mizutani, T. and Kanazawa, I. and Wanker, E.E. and Okazawa, H.
Journal of Neurochemistry 87 (1): 257-267. 1 January 2003

Lithostathine quadruple-helical filaments form proteinase K-resistant deposits in Creutzfeldt-Jakob disease.
Laurine, E. and Gregoire, C. and Faendrich, M. and Engemann, S. and Marchal, S. and Thion, L. and Mohr, M. and Monsarrat, B. and Michel, B. and Dobson, C.M. and Wanker, E.E. and Erard, M. and Verdier, J.M.
Journal of Biological Chemistry 278 (51): 51770-51778. 1 January 2003

RNA-structural mimicry in Escherichia coli ribosomal protein L4-dependent regulation of the S10 operon.
Stelzl, U. and Zengel, J.M. and Tovbina, M. and Walker, M. and Nierhaus, K.H. and Lindahl, L. and Patel, D.J.
Journal of Biological Chemistry 278 (30): 28237-28245. 1 January 2003

Identification of nuclear proteins of small cell lung cancer cell line H82: An improved procedure for the analysis of silver-stained proteins.
Gonzalez, L.J. and Castellanos-Serra, L. and Badock, V. and Diaz, M. and Moro, A. and Perea, S. and Santos, A. and Paz-Lago, D. and Otto, A. and Mueller, E.C. and Kostka, S. and Wittmann-Liebold, B. and Padron, G.
Electrophoresis 24 (1-2): 237-252. January 2003

Huntingtin fragments form aggresome-like inclusion bodies in mammalian cells.
Boeddrich, A. and Lurz, R. and Wanker, E.E.
Methods in Molecular Biology 232 : 217-229. 2003

2002

Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington's disease by using an automated filter retardation assay.
Heiser, V. and Engemann, S. and Broecker, W. and Dunkel, I. and Boeddrich, A. and Waelter, S. and Nordhoff, E. and Lurz, R. and Schugardt, N. and Rautenberg, S. and Herhaus, C. and Barnickel, G. and Boettcher, H. and Lehrach, H. and Wanker, E.E.
Proceedings of the National Academy of Sciences of the United States of America 99 (Suppl 4): 16400-16406. 10 December 2002

Compounds that inhibit HSP90 and stimulate HSP70 and HSP40, useful in the prevention or treatment of diseases associated with protein aggregation and amyloid formation [Verbindungen,die HSP90 stimulieren und HSP70 und HSP40 inhibieren, und deren Verwendung zur Prophylaxis und Behandlung von Krankheiten, die mit Protein-Aggregation und mit Amyloid-Bildung verbunden sind].
Wanker, E.E. and Sittler, A. and Hartl, U.
WO02094259A1 ; EP1387678 ; US60/288,718. 28 November 2002

Exportin-5-mediated nuclear export of eukaryotic elongation factor 1A and tRNA.
Calado, A. and Treichel, N. and Mueller, E.C. and Otto, A. and Kutay, U.
EMBO Journal 21 (22): 6216-6224. 15 November 2002

EcoRII: a restriction enzyme evolving recombination functions.
Muecke, M. and Grelle, G. and Behlke, J. and Kraft, R. and Krueger, D.H. and Reuter, M.
EMBO Journal 21 (19): 5262-5268. 1 October 2002

The Trichoderma atroviride seb1 (stress response element binding) gene encodes an AGGGG-binding protein which is involved in the response to high osmolarity stress.
Peterbauer, C.K. and Litscher, D. and Kubicek, C.P.
Molecular Genetics and Genomics 268 (2): 223-231. October 2002

Intermolecular electron transfer in cytochrome P450cam covalently bound with Tris(2,2'-bipyridyl)ruthenium(II): structural changes detected by FTIR spectroscopy.
Contzen, J. and Kostka, S. and Kraft, R. and Jung, C.
Journal of Inorganic Biochemistry 91 (4): 607-617. 20 September 2002

Generalized crystal-storing histiocytosis associated with monoclonal gammopathy: molecular analysis of a disorder with rapid clinical course and review of the literature.
Lebeau, A. and Zeindl-Eberhart, E. and Mueller, E.C. and Mueller-Hoecker, J. and Jungblut, P.R. and Emmerich, B. and Loehrs, U.
Blood 100 (5): 1817-1827. 1 September 2002

System zur automatischen Isolierung von lebenden Zellen aus tierischen Geweben [System for automatically isolating living cells from animal tissue].
Pfrieger, F.W.
DE10116155A1 ; WO0266598. 29 August 2002

Counting CAG repeats in the Huntington's disease gene by restriction endonuclease EcoP15I cleavage.
Moencke-Buchner, E. and Reich, S. and Muecke, M. and Reuter, M. and Messer, W. and Wanker, E.E. and Krueger, D.H.
Nucleic Acids Research 30 (16): e83. 15 August 2002

Phosphorylation by protein kinase CK2: A signaling switch for the caspase-inhibiting protein ARC.
Li, P.F. and Li, J.C. and Mueller, E.C. and Otto, A. and Dietz, R. and von Harsdorf, R.
Molecular Cell 10 (2): 247-258. August 2002

Detection of cathepsin B up-regulation in neoplastic thyroid tissues by proteomic analysis.
Srisomsap, C. and Subhasitanont, P. and Otto, A. and Mueller, E.C. and Punyarit, P. and Wittmann-Liebold, B. and Svasti, J.
Proteomics 2 (6): 706-712. 17 June 2002

Asymmetric photocross-linking pattern of restriction endonuclease EcoRII to the DNA recognition sequence.
Muecke, M. and Pingoud, V. and Grelle, G. and Kraft, R. and Krueger, D.H. and Reuter, M.
Journal of Biological Chemistry 277 (16): 14288-14293. 19 April 2002

Aggregation of proteins with expanded glutamine and alanine repeats of the glutamine-rich and asparagine-rich domains of Sup35 and of the amyloid β-peptide of amyloid plaques.
Perutz, M.F. and Pope, B.J. and Owen, D. and Wanker, E.E. and Scherzinger, E.
Proceedings of the National Academy of Sciences of the United States of America 99 (8): 5596-5600. 16 April 2002

The synpolydactyly homolog (spdh) mutation in the mouse -- a defect in patterning and growth of limb cartilage elements.
Albrecht, A.N. and Schwabe, G.C. and Stricker, S. and Boeddrich, A. and Wanker, E.E. and Mundlos, S.
Mechanisms of Development 112 : 53-67. 1 March 2002

Hip1 and Hippi participate in a novel cell death-signaling pathway.
Wanker, E.E.
Developmental Cell 2 (2): 126-128. February 2002

2001

Inhibition of polyglutamine aggregation in R6/2 HD brain slices-complex dose-response profiles.
Smith, D.L. and Portier, R. and Woodman, B. and Hockly, E. and Mahal, A. and Klunk, W.E. and Li, X.J. and Wanker, E.E. and Murray, K.D. and Bates, G.P.
Neurobiology of Diseases 8 : 1017-1026. 1 December 2001

CNS synaptogenesis promoted by glia-derived cholesterol.
Mauch, D.H. and Naegler, K. and Schumacher, S. and Goeritz, C. and Mueller, E.C. and Otto, A. and Pfrieger, F.W.
Science 294 (5545): 1354-1357. 9 November 2001

Protein kinase C regulates the phosphorylation and cellular localization of occludin.
Andreeva, A.Y. and Krause, E. and Mueller, E.C. and Blasig, I.E. and Utepbergenov, D.I.
Journal of Biological Chemistry 276 (42): 38480-38486. 19 October 2001

Centrosome disorganization in fibroblast cultures derived from R6/2 Huntington's disease (HD) transgenic mice and HD patients.
Sathasivam, K. and Woodman, B. and Mahal, A. and Bertaux, F. and Wanker, E.E. and Shima, D.T. and Bates, G.P.
Human Molecular Genetics 10 : 2425-2435. 1 October 2001

The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis.
Waelter, S. and Scherzinger, E. and Hasenbank, R. and Nordhoff, E. and Lurz, R. and Goehler, H. and Gauss, C. and Sathasivam, K. and Bates, G.P. and Lehrach, H. and Wanker, E.E.
Human Molecular Genetics 10 : 1807-1817. 15 August 2001

Heparin-bindende Proteine aus Gliazellen, analoge Proteine, sie kodierende Nukleinsaeuren und ihre Verwendung zum Nachweis und/oder zur Behandlung von Laesionen des Zentralnervensystems.
Pfrieger, F.W. and Schumacher, S. and Mauch, D.
DE19959934A1. 13 June 2001

Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease.
Sittler, A. and Lurz, R. and Lueder, G. and Priller, J. and Lehrach, H. and Hayer-Hartl, M.K. and Hartl, F.U. and Wanker, E.E.
Human Molecular Genetics 10 : 1307-1315. 1 June 2001

Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation.
Waelter, S. and Boeddrich, A. and Lurz, R. and Scherzinger, E. and Lueder, G. and Lehrach, H. and Wanker, E.E.
Molecular Biology of the Cell 12 (5): 1393-1407. May 2001

Tyrosine phosphorylation patterns and size modification of the Helicobacter pyori CagA protein after translocation into gastric epithelial cells.
Backert, S. and Mueller, E.C. and Jungblut, P.R. and Meyer, T.F.
Proteomics 1 (4): 608-617. April 2001

Apoptosis-induced cleavage of keratin 15 and keratin 17 in a human breast epithelial cell line.
Badock, V. and Steinhusen, U. and Bommert, K. and Wittmann-Liebold, B. and Otto, A.
Cell Death and Differentiation 8 (3): 308-315. 1 March 2001

Analysis of mouse beta-haptoglobin chain by lectin affinoblotting detection.
Roemer, I. and Vogel, T. and Otto, A. and Fichtner, I. and Klose, J.
Electrophoresis 22 : 3038-3042. 1 January 2001

Assignment of the huntingtin (Hdh) gene, the huntingtin associated protein (Hap1) gene, and the huntingtin interacting protein (Hip1) gene to rat chromosomes 14, 10, and 12 by radiation hybrid mapping and fluorescent in situ hybridization.
Zimdahl, H. and Goesele, C. and Luetjens, G. and Gruetzner, F. and Kreitler, T. and Voss, K. and Wanker, E.E. and Knoblauch, M.
Cytogenetics and Cell Genetics 94 : 101-104. 1 January 2001

COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system.
Bech-Otschir, D. and Kraft, R. and Huang, X.H. and Henklein, P. and Kapelari, B. and Pollmann, C. and Dubiel, W.
EMBO Journal 20 (7): 1630-1639. 1 January 2001

Characterization and crystallization of a novel Sarcocystis muris lectin, SML-2.
Mueller, J.J. and Mueller, E.C. and Montag, T. and Zyto, N. and Loeschner, B. and Klein, H. and Heineman, U. and Otto, A.
Acta Crystallographica Section D 57 (7): 1042-1045. 1 January 2001

Covalently crosslinked complexes of bovine adrenodoxin with adrenodoxin reductase and cytochrome P450scc. Mass spectrometry and Edman degradation of complexes of the steroidogenic hydroxylase system.
Mueller, E.C. and Lapko, A. and Otto, A. and Mueller, J.J. and Ruckpaul, K. and Heinemann, U.
European Journal of Biochemistry 268 (6): 1837-1843. 1 January 2001

Defined sequence segments of the small heat shock proteins HSP25 and alphaB-crystallin inhibit actin polymerization.
Wieske, M. and Benndorf, R. and Behlke, J. and Doelling, R. and Grelle, G. and Bielka, H. and Lutsch, G.
European Journal of Biochemistry 268 (7): 2083-2090. 1 January 2001

Glyceraldehyde-3-phosphate dehydrogenase is responsible for intranuclear localization of some oligonucleotides.
Tomasi, V. and Laktionov, P.P. and Bryksin, A.V. and Volod'ko, N.V. and Griffoni, C. and Rykova, E.V. and Spisni, E. and Kraft, R. and Vlassov, V.V.
Nucleosides Nucleotides & Nucleic Acids 20 : 863-867. 1 January 2001

Human monoclonal rheumatoid synovial B Lymphocyte hybridoma with a new disease-related specificity for cartilage oligomeric matrix protein.
Souto-Carneiro, M.M. and Burkhardt, H. and Mueller, E.C. and Hermann, R. and Otto, A. and Kraetsch, H.G. and Sack, U. and Koenig, A. and Heinegard, D. and Muller-Hermelink, H.K. and Krenn, V.
Journal of Immunology 166 : 4202-4208. 1 January 2001

Identification of acidic, low molecular mass proteins of Mycobacterium tuberculosis strain H37Rv by matrix-assisted laser desorption/ionization and electrospray ionization mass spectrometry.
Mattow, J. and Jungblut, P.R. and Mueller, E.C. and Kaufmann, S.H.E.
Proteomics 1 (4): 494-507. 1 January 2001

Identification of nucleolin as a new L-selectin ligand.
Harms, G. and Kraft, R. and Grelle, G. and Volz, B. and Dernedde, J. and Tauber, R.
Biochemical Journal 360 : 531-538. 1 January 2001

Identification of proteins from Mycobacterium tuberculosis missing in attenuated Mycobacterium bovis BCG strains.
Mattow, J. and Jungblut, P.R. and Schaible, U.E. and Mollenkopf, H.J. and Lamer, S. and Zimny-Arndt, U. and Hagens, K. and Mueller, E.C. and Kaufmann, S.H.E.
Electrophoresis 22 : 2936-2946. 1 January 2001

Importin 13: a novel mediator of nuclear import and export.
Mingot, J.M. and Kostka, S. and Kraft, R. and Hartmann, E. and Goerlich, D.
EMBO Journal 20 : 3685-3694. 1 January 2001

Multiple pathways contribute to nuclear import of core histones.
Muehlhaeusser, P. and Mueller, E.C. and Otto, A. and Kutay, U.
EMBO Reports 2 (8): 690-696. 1 January 2001

Prefractionation of protein samples for proteome analysis using reversed-phase high-performance liquid chromatography.
Badock, V. and Steinhusen, U. and Bommert, K. and Otto, A.
Electrophoresis 22 (14): 2856-2864. 1 January 2001

Proteomics reveals open reading frames in Mycobacterium tuberculosis H37Rv not predicted by genomics.
Jungblut, P.R. and Mueller, E.C. and Mattow, J. and Kaufmann, S.H.E.
Infection and Immunity 69 : 5905-5907. 1 January 2001

Regulation of phosphotransferase activity of hexokinase 2 from Saccharomyces cerevisiae by modification at serine-14.
Golbik, R. and Naumann, M. and Otto, A. and Mueller, E.C. and Behlke, J. and Reuter, R. and Kriegel, T.M.
Biochemistry 40 (4): 1083-1090. 1 January 2001

Sm protein-Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure.
Urlaub, H. and Raker, V.A. and Kostka, S. and Luehrmann, R.
EMBO Journal 20 (1-2): 187-196. 1 January 2001

The Rossmann fold of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a nuclear docking site for antisense oligonucleotides containing a TAAAT motif.
Griffoni, C. and Laktionov, P.P. and Rykova, E.Y. and Spisni, E. and Riccio, M. and Santi, S. and Bryksin, A. and Volodko, N. and Kraft, R. and Vlassov, V. and Tomasi, V.
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 1530 (1): 32-46. 1 January 2001

The nuclear orphan receptor TR4 promotes proliferation of myeloid progenitor cells.
Koritschoner, N.P. and Madruga, J. and Knespel, S. and Blendinger, G. and Anzinger, B. and Otto, A. and Zenke, M. and Bartunek, P.
Cell Growth and Differentiation 12 (11): 563-572. 1 January 2001

Deactivation of regulatory proteins hnRNP A1 and A2 during SC-1 induced apoptosis.
Hermann, R. and Hensel, F. and Mueller, E.C. and Keppler, M. and Souto-Carneiro, M. and Braendlein, S. and Mueller-Hermelink, H.K. and Vollmers, H.P.
Human Antibodies 10 (2): 83-90. 2001

2000

Protein aggregation in Huntington's and Parkinson's disease: implications for therapy.
Wanker, E.E.
Molecular Medicine Today 6 : 387-391. 1 October 2000

Novel genes coding for lithotrophic sulfur oxidation of Paracoccus pantotrophus GB17.
Friedrich, C.G. and Quentmeier, A. and Bardischewsky, F. and Rother, D. and Kraft, R. and Kostka, S. and Prinz, H.
Journal of Bacteriology 182 : 4677-4687. 1 September 2000

Protein aggregation and pathogenesis of Huntington's disease: mechanisms and correlations.
Wanker, E.E.
Biological Chemistry 381 : 937-942. 1 September 2000

Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes.
Lipowsky, G. and Bischoff, F.R. and Schwarzmaier, P. and Kraft, R. and Kostka, S. and Hartmann, E. and Kutay, U. and Goerlich, D.
EMBO Journal 19 : 4362-4371. 15 August 2000

TNF-alpha-mediated neutrophil apoptosis involves Ly-GDI, a Rho GTPase regulator.
Kettritz, R. and Xu, Y.X. and Faass, B. and Klein, J.B. and Mueller, E.C. and Otto, A. and Busjahn, A. and Luft, F.C. and Haller, H.
Journal of Leukocyte Biology 68 : 277-283. 1 August 2000

Profilin I attached to the Golgi is required for the formation of constitutive transport vesicles at the trans-Golgi network.
Dong, J. and Radau, B. and Otto, A. and Mueller, E.C. and Lindschau, C. and Westermann, P.
Biochimica et Biophysica Acta - Molecular Cell Research 1497 (2): 253-260. 21 July 2000

Overexpression of the proteasome subunits LMP2, LMP7, and MECL-1, but not PA28 alpha/beta, enhances the presentation of an immunodominant lymphocytic choriomeningitis virus T cell epitope.
Schwarz, K. and van den Broek, M. and Kostka, S. and Kraft, R. and Soza, A. and Schmidtke, G. and Kloetzel, P.M. and Groettrup, M.
Journal of Immunology 165 (2): 768-778. 15 July 2000

Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils.
Muchowski, P.J. and Schaffar, G. and Sittler, A. and Wanker, E.E. and Hayer-Hartl, M.K. and Hartl, F.U.
Proceedings of the National Academy of Sciences of the United States of America 97 (14): 7841-7846. 5 July 2000

Protein kinase Calpha-dependent phosphorylation of golgi proteins.
Radau, B. and Otto, A. and Mueller, E.C. and Westermann, P.
Electrophoresis 21 : 2684-2687. 1 July 2000

The selective proteasome inhibitors lactacystin and epoxomicin can be used to either up- or down-regulate antigen presentation at nontoxic doses.
Schwarz, K. and de Giuli, R. and Schmidtke, G. and Kostka, S. and van den Broek, M. and Kim, K.B. and Crews, C.M. and Kraft, R. and Groettrup, M.
Journal of Immunology 164 (12): 6147-6157. 15 June 2000

Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: implications for Huntington's disease therapy.
Heiser, V. and Scherzinger, E. and Boeddrich, A. and Nordhoff, E. and Lurz, R. and Schugardt, N. and Lehrach, H. and Wanker, E.E.
Proceedings of the National Academy of Sciences of the United States of America 97 (12): 6739-6744. 6 June 2000

The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription.
Steffan, J.S. and Kazantsev, A. and Spasic-Boskovic, O. and Greenwald, M. and Zhu, Y.Z. and Gohler, H. and Wanker, E.E. and Bates, G.P. and Housman, D.E. and Thompson, L.M.
Proceedings of the National Academy of Sciences of the United States of America 97 : 6763-6768. 6 June 2000

Mammalian Sec61 is associated with Sec62 and Sec63.
Meyer, H.A. and Grau, H. and Kraft, R. and Kostka, S. and Prehn, S. and Kalies, K.U. and Hartmann, E.
Journal of Biological Chemistry 275 (19): 14550-14557. 12 May 2000

Phosphorylation of Oct-2 at sites located in the POU domain induces differential down-regulation of Oct-2 DNA-binding ability.
Pevzner, V. and Kraft, R. and Kostka, S. and Lipp, M.
Biochemical Journal 347 (1): 29-35. 1 April 2000

GDP dissociation inhibitor D4-GDI (Rho-GDI 2), but not the homologous Rho-GDI 1, is cleaved by caspase-3 during drug-induced apoptosis.
Essmann, F. and Wieder, T. and Otto, A. and Mueller, E.C. and Doerken, B. and Daniel, P.T.
Biochemical Journal 346 (3): 777-783. 15 March 2000

Biochemical analysis of proteasomes from mouse microglia: Induction of immunoproteasomes by interferon-gamma and lipopolysaccharide.
Stohwasser, R. and Giesebrecht, J. and Kraft, R. and Mueller, E.C. and Haeusler, K.G. and Kettenmann, H. and Hanisch, U.K. and Kloetzel, P.M.
Glia 29 (4): 355-365. 15 February 2000

Characterization of a new type of sulfite dehydrogenase from Paracoccus pantotrophus GB17.
Quentmeier, A. and Kraft, R. and Kostka, S. and Klockenkaemper, R. and Friedrich, C.G.
Archives of Microbiology 173 (2): 117-125. 1 February 2000

A general approach for identification of RNA-Protein cross-linking sites within native human spliceosomal small nuclear ribonucleoproteins (snRNPs) - Analysis of RNA-protein contacts in native U1 and U4/U6.U5 snRNPs.
Urlaub, H. and Hartmuth, K. and Kostka, S. and Grelle, G. and Luehrmann, R.
Journal of Biological Chemistry 275 (52): 41458-41468. 1 January 2000

Interaction between interferon consensus sequence-binding protein and COP9/signalosome subunit CSN2 (Trip15) - A possible link between interferon regulatory factor signaling and the COP9/signalosome.
Cohen, H. and Azriel, A. and Cohen, T. and Meraro, D. and Hashmueli, S. and Bech-Otschir, D. and Kraft, R. and Dubiel, W. and Levi, B.Z.
Journal of Biological Chemistry 275 (50): 39081-39089. 1 January 2000

Investigation of apoptosis-involved processes by mass spectrometric identification of the apoptosis-associated proteins in IgM-induced burkitt lymphoma cells.
Mueller, E.C. and Wittmann-Liebold, B. and Otto, A.
In: Mass Spectrometry in Biology and Medicine. Humana Press, Totowa, 271-287. ISBN 0-89603-799-1 1 January 2000

1999

Folding of oligoglutamines: a theoretical approach based upon thermodynamics and molecular mechanics.
Starikov, E.B. and Lehrach, H. and Wanker, E.E.
Journal of Biomolecular Structure & Dynamics 17 : 409-427. 1 December 1999

Signaling from beta-adrenoceptor to L-type calcium channel: identification of a novel cardiac protein kinase A target possessing similarities to AHNAK.
Haase, H. and Podzuweit, T. and Lutsch, G. and Hohaus, A. and Kostka, S. and Lindschau, C. and Kott, M. and Kraft, R. and Morano, I.
FASEB Journal 13 (15): 2161-2172. December 1999

T-cell-activating monoclonal antibodies, reacting with both leukocytes and erythrocytes, recognize the guinea pig Thy-1 differentiation antigen: Characterization and cloning of guinea pig CD90.
Schaefer, H. and Bartels, T. and Hahn, G. and Otto, A. and Burger, R.
Cellular Immunology 197 (2): 116-128. 1 November 1999

Megalin knockout mice as an animal model of low molecular weight proteinuria.
Leheste, J.R. and Rolinski, B. and Vorum, H. and Hilpert, J. and Nykjaer, A. and Jacobsen, C. and Aucouturier, P. and Moskaug, J.O. and Otto, A. and Christensen, E.I. and Willnow, T.E.
American Journal of Pathology 155 (4): 1361-1370. 1 October 1999

The base of the proteasome regulatory particle exhibits chaperone-like activity.
Braun, B.C. and Glickman, M. and Kraft, R. and Dahlmann, B. and Kloetzel, P.M. and Finley, D. and Schmidt, M.
Nature Cell Biology 1 (4): 221-226. 1 August 1999

Cyanophycinase, a peptidase degrading the cyanobacterial reserve material multi-L-arginyl-poly-L-aspartic acid (cyanophycin) - Molecular cloning of the gene of Synechocystis sp PCC 6803, expression in Escherichia coli, and biochemical characterization of the purified enzyme.
Richter, R. and Hejazi, M. and Kraft, R. and Ziegler, K. and Lockau, W.
European Journal of Biochemistry 263 : 163-169. 1 July 1999

Proteomics in human disease: cancer,heart and infectious diseases.
Jungblut, P.R. and Zimny-Arndt, U. and Zeindl-Eberhart, E. and Stulik, J. and Koupilova, K. and Pleissner, K.P. and Otto, A. and Mueller, E.C. and Sokolowska-Koehler, W. and Grabher, G. and Stoeffler, G.
Electrophoresis 20 (10): 2100-2110. July 1999

Aggregation of truncated GST-HD exon 1 fusion proteins containing normal range and expanded glutamine repeats.
Hollenbach, B. and Scherzinger, E. and Schweiger, K. and Lurz, R. and Lehrach, H. and Wanker, E.E.
Philosophical Transactions of the Royal Society of London Series B Biological Sciences 354 : 991-994. 29 June 1999

MAPKAP kinase 2 phosphorylates serum response factor in vitro and in vivo.
Heidenreich, O. and Neininger, A. and Schratt, G. and Zinck, R. and Cahill, M.A. and Engel, K. and Kotlyarov, A. and Kraft, R. and Kostka, S. and Gaestel, M. and Nordheim, A.
Journal of Biological Chemistry 274 : 14434-14443. 14 May 1999

Formation of polyglutamine inclusions in non-CNS tissue.
Sathasivam, K. and Hobbs, C. and Turmaine, M. and Mangiarini, L. and Mahal, A. and Bertaux, F. and Wanker, E.E. and Doherty, P. and Davies, S.W. and Bates, G.P.
Human Molecular Genetics 8 : 813-822. 1 May 1999

Nucleoid proteins of pea chloroplasts: Detection of a protein homologous to ribosomal protein.
Oleskina, Y.P. and Yurina, N.P. and Odintsova, T.I. and Egorov, T.A. and Otto, A. and Wittmann-Liebold, B. and Odintsova, M.S.
Biochemistry and Molecular Biology International 47 : 757-763. 1 May 1999

Sequence information within proteasomal prosequences mediates efficient integration of beta-subunits into the 20 S proteasome complex.
Schmidt, M. and Zantopf, D. and Kraft, R. and Kostka, S. and Preissner, R. and Kloetzel, P.M.
Journal of Molecular Biology 288 : 117-128. 23 April 1999

Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: implications for Huntington's disease pathology.
Scherzinger, E. and Sittler, A. and Schweiger, K. and Heiser, V. and Lurz, R. and Hasenbank, R. and Bates, G.P. and Lehrach, H. and Wanker, E.E.
Proceedings of the National Academy of Sciences of the United States of America 96 (8): 4604-4609. 13 April 1999

Huntington's disease intranuclear inclusions contain truncated, ubiquitinated huntingtin protein.
Sieradzan, K.A. and Mechan, A.O. and Jones, L. and Wanker, E.E. and Nukina, N. and Mann, D.M.
Experimental Neurology 156 (1): 92-99. 1 March 1999

Cloning and characterization of a gene (mspA) encoding the major sheath protein Treponema maltophilum ATCC51939(T).
Heuner, K. and Choi, B.K. and Schade, R. and Moter, A. and Otto, A. and Goebel, U.B.
Journal of Bacteriology 181 : 1025-1029. 1 February 1999

Laccase of Coriolus zonatus - Isolation, purification, and some physicochemical properties.
Koroljova, O.V. and Stepanova, E.V. and Gavrilova, V.P. and Biniukov, V.I. and Jaropolov, A.I. and Varfolomeyev, S.D. and Scheller, F.W. and Makower, A. and Otto, A.
Applied Biochemistry and Biotechnology 76 : 115-127. 1 February 1999

Study of Burkitt lymphoma cell line proteins by high resolution two-dimensional gel electrophoresis and nanoelectrospray mass spectrometry.
Mueller, E.C. and Schuemann, M. and Rickers, A. and Bommert, K. and Wittmann-Liebold, B. and Otto, A.
Electrophoresis 20 : 320-330. 1 February 1999

Preparative high-resolution two-dimensional electrophoresis enables the identification of RNA polymerase B transcription factor 3 as an apoptosis-associated protein in the human BL60-2 Burkitt lymphoma cell line.
Brockstedt, E. and Otto, A. and Rickers, A. and Bommert, K. and Wittmann-Liebold, B.
Journal of Protein Chemistry 18 (2): 225-231. February 1999

ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28.
Hutloff, A. and Dittrich, A.M. and Beier, K.C. and Eljaschewitsch, B. and Kraft, R. and Anagnostopoulos, I. and Kroczek, R.A.
Nature 397 (6716): 263-266. 21 January 1999

Detection of polyglutamine aggregation in mouse models.
Davies, S.W. and Sathasivam, K. and Hobbs, C. and Doherty, P. and Mangiarini, L. and Scherzinger, E. and Wanker, E.E. and Bates, G.P.
Methods in Enzymology 309 : 687-701. 1 January 1999

Membrane filter assay for detection of amyloid-like polyglutamine-containing protein aggregates.
Wanker, E.E. and Scherzinger, E. and Heiser, V. and Sittler, A. and Eickhoff, H. and Lehrach, H.
Methods in Enzymology 309 : 375-386. 1 January 1999

1998

Characterization of the mouse Src homology 3 domain gene Sh3d2c on Chr 7 demonstrates coexpression with huntingtin in the brain and identifies the processed pseudogene Sh3d2c-ps1 on Chr 2.
Zechner, U. and Scheel, S. and Hemberger, M. and Hopp, M. and Haaf, T. and Fundele, R. and Wanker, E.E. and Lehrach, H. and Wedemeyer, N. and Himmelbauer, H.
Genomics 54 : 505-510. 15 December 1998

Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line - cleavage of heterogeneous nuclear ribonucleoprotein A1 by caspase 3.
Brockstedt, E. and Rickers, A. and Kostka, S. and Laubersheimer, A. and Doerken, B. and Wittmann-Liebold, B. and Bommert, K. and Otto, A.
Journal of Biological Chemistry 273 (43): 28057-28064. 23 October 1998

SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates.
Sittler, A. and Walter, S. and Wedemeyer, N. and Hasenbank, R. and Scherzinger, E. and Eickhoff, H. and Bates, G.P. and Lehrach, H. and Wanker, E.E.
Molecular Cell 2 (4): 427-436. October 1998

Identification of mouse crystallins in 2D protein patterns by sequencing and mass spectrometry. Application to cataract mutants.
Jungblut, P.R. and Otto, A. and Favor, J. and Loewe, M. and Mueller, E.C. and Kastner, M. and Sperling, K. and Klose, J.
FEBS Letters 435 : 131-137. 18 September 1998

Precise determination of RNA-protein contact sites in the 50 S ribosomal subunit of Escherichia coli.
Thiede, B. and Urlaub, H. and Neubauer, H. and Grelle, G. and Wittmann-Liebold, B.
Biochemical Journal 334 P.1 : 39-42. 15 August 1998

High performance two dimensional gel electrophoresis and nanoelectrospray mass spectrometry as powerful tool to study apoptosis-associated processes in a Burkitt lymphoma cell line.
Otto, A. and Mueller, E.C. and Brockstedt, E. and Schumann, M. and Rickers, A. and Bommert, K. and Wittmann-Liebold, B.
Journal of Protein Chemistry 17 : 564-565. 1 August 1998

Polyglutamine expansion and Huntington's disease.
Bates, G.P. and Mangiarini, L. and Wanker, E.E. and Davies, S.W.
Biochemical Society Transactions 26 : 471-475. 1 August 1998

The monoclonal antibody AS02 recognizes a protein on human fibroblasts being highly homologous to Thy-1.
Saalbach, A. and Kraft, R. and Herrmann, K. and Haustein, U.F. and Anderegg, U.
Archives of Dermatological Research 290 : 360-366. 1 July 1998

Ataxin-3 is transported into the nucleus and associates with the nuclear matrix.
Tait, D. and Riccio, M. and Sittler, A. and Scherzinger, E. and Santi, S. and Ognibene, A. and Maraldi, N.M. and Lehrach, H. and Wanker, E.E.
Human Molecular Genetics 7 (6): 991-997. June 1998

Huntingtin aggregation monitored by dynamic light scattering.
Georgalis, Y. and Starikov, E.B. and Hollenbach, B. and Lurz, R. and Scherzinger, E. and Saenger, W. and Lehrach, H. and Wanker, E.E.
Proceedings of the National Academy of Sciences of the United States of America 95 (11): 6118-6121. 26 May 1998

HAP1-huntingtin interactions do not contribute to the molecular pathology in Huntington's disease transgenic mice.
Bertaux, F. and Sharp, A.H. and Ross, C.A. and Lehrach, H. and Bates, G.P. and Wanker, E.E.
FEBS Letters 426 : 229-232. 17 April 1998

A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits.
Seeger, M. and Kraft, R. and Ferrell, K. and Bech-Otschir, D. and Dumedey, R. and Schade, R. and Gordon, C. and Naumann, M. and Dubiel, W.
FASEB Journal 12 (6): 469-478. 1 April 1998

Acid nuclear extracts as mediators of gene transfer and expression.
Boettger, M. and Zaitsev, S.V. and Otto, A. and Haberland, A. and Vorob'ev, V.I.
Biochimica et Biophysica Acta 1395 : 78-87. 1 January 1998

Hexokinase 2 from Saccharomyces cerevisiae: regulation of oligomeric structure by in vivo phosphorylation at serine-14.
Behlke, J. and Heidrich, K. and Naumann, M. and Mueller, E.C. and Otto, A. and Reuter, R. and Kriegel, T.
Biochemistry 37 : 11989-11995. 1 January 1998

IRS-PCR-based genetic mapping of the huntingtin interacting protein gene (HIP1) on mouse chromosome 5.
Himmelbauer, H. and Wedemeyer, N. and Haaf, T. and Wanker, E.E. and Schalkwyk, L.C. and Lehrach, H.
Mammalian Genome 9 : 26-31. 1 January 1998

Inhibition of CPP32 blocks surface IgM-mediated apoptosis and D4-GDI cleavage in human BL 60 Burkitt lymphoma cells.
Rickers, A. and Brockstedt, E. and Mapara, M.Y. and Otto, A. and Doerken, B. and Bommert, K.
European Journal of Immunology 28 : 296-304. 1 January 1998

Mammalian protein homologous to VAT-1 of torpedo californica: isolation from Ehrlich Ascites Tumor cells, biochemical characterization and organization of its gene.
Hayess, K. and Kraft, R. and Sachsinger, J. and Janke, J. and Jandrig, B. and Beckmann, G. and Rohde, K. and Benndorf, R.
Journal of Cellular Biochemistry 69 : 304-315. 1 January 1998

1997

Localization of the human HIP1 gene close to the elastin (ELN) locus on 7q11.23.
Wedemeyer, N. and Peoples, R. and Himmelbauer, H. and Lehrach, H. and Francke, U. and Wanker, E.E.
Genomics 46 : 313-315. 1 December 1997

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation.
Davies, S.W. and Turmaine, M. and Cozens, B.A. and DiFiglia, M. and Sharp, A.H. and Ross, C.A. and Scherzinger, E. and Wanker, E.E. and Mangiarini, L. and Bates, G.P.
Cell 90 (3): 537-548. 8 August 1997

Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo.
Scherzinger, E. and Lurz, R. and Turmaine, M. and Mangiarini, L. and Hollenbach, B. and Hasenbank, R. and Bates, G.P. and Davies, S.W. and Lehrach, H. and Wanker, E.E.
Cell 90 (3): 549-558. 8 August 1997

HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system.
Wanker, E.E. and Rovira, C. and Scherzinger, E. and Hasenbank, R. and Walter, S. and Tait, D. and Colicelli, J. and Lehrach, H.
Human Molecular Genetics 6 (3): 487-495. 1 March 1997

Chicken acidic leucine-rich EGF-like domain containing brain protein (CALEB), a neural member of the EGF family of differentiation factors, is implicated in neurite formation.
Schumacher, S. and Volkmer, H. and Buck, F. and Otto, A. and Tarnok, A. and Roth, S. and Rathjen, F.G.
Journal of Cell Biology 136 (4): 895-906. 24 February 1997

Export of importin alpha from the nucleus is mediated by a specific nuclear transport factor.
Kutay, U. and Bischoff, F.R. and Kostka, S. and Kraft, R. and Goerlich, D.
Cell 90 : 1061-1071. 1 January 1997

Identification and characterization of heat shock protein 27 protein species in human myocardial two-dimensional electrophoresis patterns.
Scheler, C. and Mueller, E.C. and Stahl, J. and Mueller-Werdan, U. and Salnikov, J. and Jungblut, P.
Electrophoresis 18 : 2823-2831. 1 January 1997

Purification, structural analysis, and function of natural atac, a cytokine secreted by cd8(+) T cells.
Dorner, B. and Mueller, S. and Entschladen, F. and Schroeder, J.M. and Frankel, P. and Kraft, R. and Friedl, P. and Clarklewis, I. and Kroczek, R.A.
Journal of Biological Chemistry 272 : 8817-8823. 1 January 1997

1995

Efficient secretion of Bacillus subtilis levanase by Saccharomyces cerevisiae.
Wanker, E.E. and Klingsbichel, E. and Schwab, H.
Gene 161 : 45-49. 8 August 1995

Functional characterization of the 180-kD ribosome receptor in vivo.
Wanker, E.E. and Sun, Y. and Savitz, A.J. and Meyer, D.I.
Journal of Cell Biology 130 (1): 29-39. July 1995

Expression of Bacillus subtilis levanase gene in Lactobacillus plantarum and Lactobacillus casei.
Wanker, E.E. and Leer, R.J. and Pouwels, P.H. and Schwab, H.
Applied Microbiology and Biotechnology 43 : 297-303. 1 May 1995

Purification and characterization of the Bacillus subtilis levanase produced in Escherichia coli.
Wanker, E.E. and Huber, A. and Schwab, H.
Applied and Environmental Microbiology 61 : 1953-1958. 1 May 1995

1991

Expression of the Bacillus subtilis levanase gene in Escherichia coli and Saccharomyces cerevisiae.
Wanker, E.E. and Schorgendorfer, K. and Schwab, H.
Journal of Biotechnology 18 : 243-254. 1 May 1991

This list was generated on Wed Nov 14 02:19:28 2018 CET.
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