2024
AI promoted virtual screening, structure-based hit optimization, and synthesis of novel COVID-19 S-RBD domain inhibitors.
Gkekas, I., Katsamakas, S., Mylonas, S., Fotopoulou, T., Magoulas, G.Ε., Tenchiu, A.C., Dimitriou, M., Axenopoulos, A., Rossopoulou, N., Kostova, S., Wanker, E.E., Katsila, T., Papahatjis, D., Gorgoulis, V.G., Koufaki, M., Karakasiliotis, I., Calogeropoulou, T., Daras, P. and Petrakis, S.
Journal of Chemical Information and Modeling
13 November 2024
(In Press)
Mutant huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure.
Lisowski, P., Lickfett, S., Rybak-Wolf, A., Menacho, C., Le, S., Pentimalli, T.M., Notopoulou, S., Dykstra, W., Oehler, D., López-Calcerrada, S., Mlody, B., Otto, M., Wu, H., Richter, Y., Roth, P., Anand, R., Kulka, L.A.M., Meierhofer, D., Glazar, P., Legnini, I., Telugu, N.S., Hahn, T., Neuendorf, N., Miller, D.C., Böddrich, A., Polzin, A., Mayatepek, E., Diecke, S., Olzscha, H., Kirstein, J., Ugalde, C., Petrakis, S., Cambridge, S., Rajewsky, N., Kühn, R., Wanker, E.E., Priller, J., Metzger, J.J. and Prigione, A.
Nature Communications 15
(1): 7027.
22 August 2024
Towards standardizing nomenclature in Huntington's disease research.
DiFiglia, M., Leavitt, B.R., Macdonald, D. and Thompson, L.M.
Journal of Huntington's disease 13
(2): 119-131.
2 July 2024
Polyglutamine disease proteins: Commonalities and differences in interaction profiles and pathological effects.
Bonsor, M., Ammar, O., Schnoegl, S., Wanker, E.E. and Silva Ramos, E.
Proteomics 24
(12-13): e2300114.
June 2024
AI-guided pipeline for protein-protein interaction drug discovery identifies an SARS-CoV-2 inhibitor.
Trepte, P., Secker, C., Olivet, J., Blavier, J., Kostova, S., Maseko, S.B., Minia, I., Silva Ramos, E., Cassonnet, P., Golusik, S., Zenkner, M., Beetz, S., Liebich, M.J., Scharek, N., Schutz, A., Sperling, M., Lisurek, M., Wang, Y., Spirohn, K., Hao, T., Calderwood, M.A., Hill, D.E., Landthaler, M., Choi, S.G., Twizere, J.C., Vidal, M. and Wanker, E.E.
Molecular Systems Biology 20
(4): 428-457.
2 April 2024
A TBK1 variant causes autophagolysosomal and motoneuron pathology without neuroinflammation in mice.
Brenner, D., Sieverding, K., Srinidhi, J., Zellner, S., Secker, C., Yilmaz, R., Dyckow, J., Amr, S., Ponomarenko, A., Tunaboylu, E., Douahem, Y., Schlag, J.S., Rodríguez Martínez, L., Kislinger, G., Niemann, C., Nalbach, K., Ruf, W.P., Uhl, J., Hollenbeck, J., Schirmer, L., Catanese, A., Lobsiger, C.S., Danzer, K.M., Yilmazer-Hanke, D., Münch, C., Koch, P., Freischmidt, A., Fetting, M., Behrends, C., Parlato, R. and Weishaupt, J.H.
Journal of Experimental Medicine 221
(5): e20221190.
22 March 2024
Huntingtin protein–protein interactions: From biology to therapeutic targets.
Silva Ramos, E., Greco, T.M., Cristea, I.M. and Wanker, E.E.
In:
Huntington's Disease.
Elsevier, New York, NY, USA, 159-186.
ISBN pub.1168955041
16 February 2024
2023
Novel multi-objective affinity approach allows to identify pH-specific μ-opioid receptor agonists.
Secker, C., Fackeldey, K., Weber, M., Ray, S., Gorgulla, C. and Schütte, C.
Journal of Cheminformatics 15
(1): 85.
19 September 2023
Delineation of functional subdomains of Huntingtin protein and their interaction with HAP40.
Alteen, M.G., Deme, J.C., Alvarez, C.P., Loppnau, P., Hutchinson, A., Seitova, A., Chandrasekaran, R., Silva Ramos, E., Secker, C., Alqazzaz, M., Wanker, E.E., Lea, S.M., Arrowsmith, C.H. and Harding, R.J.
Structure 31
(9): 1121-1131.e6.
7 September 2023
A proteomics analysis of 5xFAD mouse brain regions reveals the lysosome-associated protein Arl8b as a candidate biomarker for Alzheimer's disease.
Boeddrich, A., Haenig, C., Neuendorf, N., Blanc, E., Ivanov, A., Kirchner, M., Schleumann, P., Bayraktaroğlu, I., Richter, M., Molenda, C.M., Sporbert, A., Zenkner, M., Schnoegl, S., Suenkel, C., Schneider, L.S., Rybak-Wolf, A., Kochnowsky, B., Byrne, L.M., Wild, E.J., Nielsen, J.E., Dittmar, G., Peters, O., Beule, D. and Wanker, E.E.
Genome Medicine 15
(1): 50.
20 July 2023
The polyphenol EGCG directly targets intracellular amyloid-β aggregates and promotes their lysosomal degradation.
Secker, C., Motzny, A.Y., Kostova, S., Buntru, A., Helmecke, L., Reus, L., Steinfort, R., Brusendorf, L., Boddrich, A., Neuendorf, N., Diez, L., Schmieder, P., Schulz, A., Czekelius, C. and Wanker, E.E.
Journal of Neurochemistry 166
(2): 294-317.
18 July 2023
Generation of an induced pluripotent stem cell line from a Huntington's disease patient with a long HTT-PolyQ sequence.
Miller, D.C., Lisowski, P., Genehr, C., Wanker, E.E., Priller, J., Prigione, A. and Diecke, S.
Stem Cell Research 68
: 103056.
April 2023
Early detection of exon 1 huntingtin aggregation in zQ175 brains by molecular and histological approaches.
Smith, E.J., Sathasivam, K., Landles, C., Osborne, G.F., Mason, M.A., Gomez-Paredes, C., Taxy, B.A., Milton, R.E., Ast, A., Schindler, F., Zhang, C., Duan, W., Wanker, E.E. and Bates, G.P.
Brain Communications 5
(1): fcad010.
20 January 2023
2022
Generation of induced pluripotent stem cells from three individuals with Huntington's disease.
Miller, D.C., Lisowski, P., Lickfett, S., Mlody, B., Bünning, M., Genehr, C., Ulrich, C., Wanker, E.E., Diecke, S., Priller, J. and Prigione, A.
Stem Cell Research 65
: 102976.
December 2022
Generation of four iPSC lines from four patients with Leigh syndrome carrying homoplasmic mutations m.8993T > G or m.8993T > C in the mitochondrial gene MT-ATP6.
Lorenz, C., Zink, A., Henke, M.T., Staege, S., Mlody, B., Bünning, M., Wanker, E., Diecke, S., Schuelke, M. and Prigione, A.
Stem Cell Research 61
: 102742.
May 2022
Dynamics of huntingtin protein interactions in the striatum identifies candidate modifiers of Huntington disease.
Greco, T.M., Secker, C., Silva Ramos, E., Federspiel, J.D., Liu, J.P., Perez, A.M., Al-Ramahi, I., Cantle, J.P., Carroll, J.B., Botas, J., Zeitlin, S.O., Wanker, E.E. and Cristea, I.M.
Cell Systems 13
(4): 304-320.e5.
22 April 2022
2021
CellFIE: CRISPR- and cell fusion-based two-hybrid interaction mapping of endogenous proteins.
Secker, C., Kostova, S., Niederlechner, H., Beetz, S., Wendland, I., Liebich, M.J., Polzer, O., Groh, M., Schnoegl, S., Trepte, P. and Wanker, E.E.
Journal of Molecular Biology 433
(24): 167305.
3 December 2021
Mitochondria in neurogenesis: implications for mitochondrial diseases.
Brunetti, D., Dykstra, W., Le, S., Zink, A. and Prigione, A.
Stem Cells 39
(10): 1289-1297.
October 2021
Schizophrenia risk candidate protein ZNF804A interacts with STAT2 and influences interferon-mediated gene transcription in mammalian cells.
Klockmeier, K., Silva Ramos, E., Raskó, T., Martí Pastor, A. and Wanker, E.E.
Journal of Molecular Biology 433
(19): 167184.
17 September 2021
Small, seeding-competent huntingtin fibrils are prominent aggregate species in brains of zQ175 Huntington's disease knock-in mice.
Schindler, F., Praedel, N., Neuendorf, N., Kunz, S., Schnoegl, S., Mason, M.A., Taxy, B.A., Bates, G.P., Khoshnan, A., Priller, J., Grimm, J., Maier, M., Boeddrich, A. and Wanker, E.E.
Frontiers in Neuroscience 15
: 682172.
22 June 2021
Generation of human brain organoids for mitochondrial disease modeling.
Le, S., Petersilie, L., Inak, G., Menacho-Pando, C., Kafitz, K.W., Rybak-Wolf, A., Rajewsky, N., Rose, C.R. and Prigione, A.
Journal of Visualized Experiments
(172): e62756.
21 June 2021
Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome.
Inak, G., Rybak-Wolf, A., Lisowski, P., Pentimalli, T.M., Jüttner, R., Glažar, P., Uppal, K., Bottani, E., Brunetti, D., Secker, C., Zink, A., Meierhofer, D., Henke, M.T., Dey, M., Ciptasari, U., Mlody, B., Hahn, T., Berruezo-Llacuna, M., Karaiskos, N., Di Virgilio, M., Mayr, J.A., Wortmann, S.B., Priller, J., Gotthardt, M., Jones, D.P., Mayatepek, E., Stenzel, W., Diecke, S., Kühn, R., Wanker, E.E., Rajewsky, N., Schuelke, M. and Prigione, A.
Nature Communications 12
(1): 1929.
26 March 2021
FEZ1 forms complexes with CRMP1 and DCC to regulate axon and dendrite development.
Chua, J.Y., Ng, S.J., Yagensky, O., Wanker, E.E. and Chua, J.J.E.
eNeuro 8
(2): ENEURO.0193-20.2021.
26 March 2021
Generation of human iPSC-derived neural progenitor cells (NPCs) as drug discovery model for neurological and mitochondrial disorders.
Zink, A., Lisowski, P. and Prigione, A.
Bio-protocol 11
(5): e3939.
5 March 2021
The ARFRP1-dependent Golgi scaffolding protein GOPC is required for insulin secretion from pancreatic β-cells.
Wilhelmi, Ilka, Grunwald, S., Gimber, N., Popp, O., Dittmar, G., Arumughan, A., Wanker, E.E., Laeger, T., Schmoranzer, J., Daumke, O. and Schümann, A.
Molecular Metabolism 45
: 101151.
March 2021
Bioenergetic profiling of human pluripotent stem cells.
Inak, G., Henke, M.T. and Prigione, A.
Methods in Molecular Biology 2277
: 391-403.
2021
2020
Megadalton-sized dityrosine aggregates of α-synuclein retain high degrees of structural disorder and internal dynamics.
Verzini, S., Shah, M., Theillet, F.X., Belsom, A., Bieschke, J., Wanker, E.E., Rappsilber, J., Binolfi, A. and Selenko, P.
Journal of Molecular Biology 432
(24): 166689.
4 December 2020
RNA sequencing of human peripheral blood cells indicates upregulation of immune-related genes in Huntington's disease.
Andrade-Navarro, M.A., Mühlenberg, K., Spruth, E.J., Mah, N., González-López, A., Andreani, T., Russ, J., Huska, M.R., Muro, E.M., Fontaine, J.F., Amstislavskiy, V., Soldatov, A., Nietfeld, W., Wanker, E.E. and Priller, J.
Frontiers in Neurology 11
: 573560.
27 November 2020
Assessment of ethanol-induced toxicity on iPSC-derived human dopaminergic neurons using a novel high-throughput mitochondrial neuronal health (MNH) assay.
Zink, A., Conrad, J., Telugu, N.S., Diecke, S., Heinz, A., Wanker, E., Priller, J. and Prigione, A.
Frontiers in Cell and Developmental Biology 8
: 590540.
5 November 2020
PDGFA-associated protein 1 protects mature B lymphocytes from stress-induced cell death and promotes antibody gene diversification.
Delgado-Benito, V., Berruezo-Llacuna, M., Altwasser, R., Winkler, W., Sundaravinayagam, D., Balasubramanian, S., Caganova, M., Graf, R., Rahjouei, A., Henke, M.T., Driesner, M., Keller, L., Prigione, A., Janz, M., Akalin, A. and Di Virgilio, M.
Journal of Experimental Medicine 217
(10): e20200137.
5 October 2020
A functionally defined high-density NRF2 interactome reveals new conditional regulators of ARE transactivation.
Poh, J., Ponsford, A.H., Boyd, J., Woodsmith, J., Stelzl, U., Wanker, E., Harper, N., MacEwan, D. and Sanderson, C.M.
Redox Biology 37
: 101686.
October 2020
Shedding a new light on Huntington's disease: how blood can both propagate and ameliorate disease pathology.
Rieux, M., Alpaugh, M., Sciacca, G., Saint-Pierre, M., Masnata, M., Denis, H.L., Lévesque, S.A., Herrmann, F., Bazenet, C., Garneau, A.P., Isenring, P., Truant, R., Oueslati, A., Gould, P.V., Ast, A., Wanker, E.E., Lacroix, S. and Cicchetti, F.
Molecular Psychiatry 26
(9): 5441–5463.
September 2020
Interactome mapping provides a network of neurodegenerative disease proteins and uncovers widespread protein aggregation in affected brains.
Haenig, C., Atias, N., Taylor, A.K., Mazza, A., Schaefer, M.H., Russ, J., Riechers, S.P., Jain, S., Coughlin, M., Fontaine, J.F., Freibaum, B.D., Brusendorf, L., Zenkner, M., Porras, P., Stroedicke, M., Schnoegl, S., Arnsburg, K., Boeddrich, A., Pigazzini, L., Heutink, P., Taylor, J.P., Kirstein, J., Andrade-Navarro, M.A., Sharan, R. and Wanker, E.E.
Cell Reports 32
(7): 108050.
18 August 2020
Mixing Aβ(1-40) and Aβ(1-42) peptides generates unique amyloid fibrils.
Cerofolini, L., Ravera, E., Bologna, S., Wiglenda, T., Böddrich, A., Purfürst, B., Benilova, I., Korsak, M., Gallo, G., Rizzo, D., Gonnelli, L., Fragai, M., De Strooper, B., Wanker, E.E. and Luchinat, C.
Chemical Communications 56
(62): 8830-8833.
11 August 2020
Subcellular localization and formation of huntingtin aggregates correlates with symptom onset and progression in a Huntington's disease model.
Landles, C., Milton, R.E., Ali, N., Flomen, R., Flower, M., Schindler, F., Gomez-Paredes, C., Bondulich, M.K., Osborne, G.F., Goodwin, D., Salsbury, G., Benn, C.L., Sathasivam, K., Smith, E.J., Tabrizi, S.J., Wanker, E.E. and Bates, G.P.
Brain Communications 2
(2): fcaa066.
3 August 2020
Tackling mitochondrial diversity in brain function: from animal models to human brain organoids.
Menacho, C. and Prigione, A.
International Journal of Biochemistry and Cell Biology 123
: 105760.
June 2020
Nuclear inclusions of pathogenic ataxin-1 induce oxidative stress and perturb the protein synthesis machinery.
Laidou, S., Alanis-Lobato, G., Pribyl, J., Raskó, T., Tichy, B., Mikulasek, K., Tsagiopoulou, M., Oppelt, J., Kastrinaki, G., Lefaki, M., Singh, M., Zink, A., Chondrogianni, N., Psomopoulos, F., Prigione, A., Ivics, Z., Pospisilova, S., Skladal, P., Izsvák, Z., Andrade-Navarro, M.A. and Petrakis, S.
Redox Biology 32
: 101458.
May 2020
Sclerotiorin stabilizes the assembly of nonfibrillar Abeta42 oligomers with low toxicity, seeding activity, and beta-sheet content.
Wiglenda, T., Groenke, N., Hoffmann, W., Manz, C., Diez, L., Buntru, A., Brusendorf, L., Neuendorf, N., Schnoegl, S., Haenig, C., Schmieder, P., Pagel, K. and Wanker, E.E.
Journal of Molecular Biology 432
(7): 2080-2098.
27 March 2020
Interleukin-12/23 deficiency differentially affects pathology in male and female Alzheimer's disease-like mice.
Eede, P., Obst, J., Benke, E., Yvon-Durocher, G., Richard, B.C., Gimber, N., Schmoranzer, J., Böddrich, A., Wanker, E.E., Prokop, S. and Heppner, F.L.
EMBO Reports 21
(3): e48530.
4 March 2020
2019
Common mode of remodeling AAA ATPases p97/CDC48 by their disassembling cofactors ASPL/PUX1.
Banchenko, S., Arumughan, A., Petrović, S., Schwefel, D., Wanker, E.E., Roske, Y. and Heinemann, U.
Structure 27
(12): 1830-1841.
3 December 2019
The pathobiology of perturbed mutant huntingtin protein-protein interactions in Huntington's disease.
Wanker, E.E., Ast, A., Schindler, F., Trepte, P. and Schnoegl, S.
Journal of Neurochemistry 151
(4): 507-519.
November 2019
DCAF8, a novel MuRF1 interaction partner, promotes muscle atrophy.
Nowak, M., Suenkel, B., Porras, P., Migotti, R., Schmidt, F., Kny, M., Zhu, X., Wanker, E.E., Dittmar, G., Fielitz, J. and Sommer, T.
Journal of Cell Science 132
(17): jcs233395.
6 September 2019
Maximizing binary interactome mapping with a minimal number of assays.
Choi, S.G., Olivet, J., Cassonnet, P., Vidalain, P.O., Luck, K., Lambourne, L., Spirohn, K., Lemmens, I., Dos Santos, M., Demeret, C., Jones, L., Rangarajan, S., Bian, W., Coutant, E.P., Janin, Y.L., van der Werf, S., Trepte, P., Wanker, E.E., De Las Rivas, J., Tavernier, J., Twizere, J.C., Hao, T., Hill, D.E., Vidal, M., Calderwood, M.A. and Jacob, Y.
Nature Communications 10
(1): 3907.
29 August 2019
Deregulated splicing is a major mechanism of RNA-induced toxicity in Huntington's disease.
Schilling, J., Broemer, M., Atanassov, I., Duernberger, Y., Vorberg, I., Dieterich, C., Dagane, A., Dittmar, G., Wanker, E., van Roon-Mom, W., Winter, J. and Krauß, S.
Journal of Molecular Biology 431
(9): 1869-1877.
19 April 2019
Live-imaging readouts and cell models for phenotypic profiling of mitochondrial function.
Iannetti, E.F., Prigione, A., Smeitink, J.A.M., Koopman, W.J.H., Beyrath, J. and Renkema, H.
Frontiers in Genetics 10
: 131.
March 2019
Neurodevelopmental disorder associated with IRF2BPL gene mutation: expanding the phenotype?
Skorvanek, M., Dusek, P., Rydzanicz, M., Walczak, A., Kosinska, J., Kostrzewa, G., Rydzanicz, M., Han, V., Dosekova, P., Gdovinova, Z., Lehotska, Z., Lisowski, P. and Ploski, R.
Parkinsonism & Related Disorders 62
: 239-241.
24 January 2019
Sirtuin 2-mediated deacetylation of cyclin-dependent kinase 9 promotes STAT1 signaling in type I interferon responses.
Kosciuczuk, E.M., Mehrotra, S., Saleiro, D., Kroczynska, B., Majchrzak-Kita, B., Lisowski, P., Driehaus, C., Rogalska, A., Turner, A., Lienhoop, T., Gius, D., Fish, E.N., Vassilopoulos, A. and Platanias, L.C.
Journal of Biological Chemistry 294
(3): 827-837.
18 January 2019
The anti-amyloid compound DO1 decreases plaque pathology and neuroinflammation-related expression changes in 5xFAD transgenic mice.
Boeddrich, A., Babila, J.T., Wiglenda, T., Diez, L., Jacob, M., Nietfeld, W., Huska, M.R., Haenig, C., Groenke, N., Buntru, A., Blanc, E., Meier, J.C., Vannoni, E., Erck, C., Friedrich, B., Martens, H., Neuendorf, N., Schnoegl, S., Wolfer, D.P., Loos, M., Beule, D., Andrade-Navarro, M.A. and Wanker, E.E.
Cell Chemical Biology 26
(1): 109-120.
17 January 2019
Novel calcineurin A (PPP3CA) variant associated with epilepsy, constitutive enzyme activation and downregulation of protein expression.
Rydzanicz, M., Wachowska, M., Cook, E.C., Lisowski, P., Kuźniewska, B., Szymańska, K., Diecke, S., Prigione, A., Szczałuba, K., Szybińska, A., Koppolu, A., Murcia Pienkowski, V., Kosińska, J., Wiweger, M., Kostrzewa, G., Brzozowska, M., Domańska-Pakieła, D., Jurkiewicz, E., Stawiński, P., Gromadka, A., Zielenkiewicz, P., Demkow, U., Dziembowska, M., Kuźnicki, J., Creamer, T.P. and Płoski, R.
European Journal of Human Genetics 27
(1): 61-69.
January 2019
2018
mHTT seeding activity: a marker of disease progression and neurotoxicity in models of Huntington's disease.
Ast, A., Buntru, A., Schindler, F., Hasenkopf, R., Schulz, A., Brusendorf, L., Klockmeier, K., Grelle, G., McMahon, B., Niederlechner, H., Jansen, I., Diez, L., Edel, J., Boeddrich, A., Franklin, S.A., Baldo, B., Schnoegl, S., Kunz, S., Purfürst, B., Gaertner, A., Kampinga, H.H., Morton, A.J., Petersén, Å., Kirstein, J., Bates, G.P. and Wanker, E.E.
Molecular Cell 71
(5): 675-688.
6 September 2018
Metformin reverses early cortical network dysfunction and behavior changes in Huntington's disease.
Arnoux, I., Willam, M., Griesche, N., Krummeich, J., Watari, H., Offermann, N., Weber, S., Narayan Dey, P., Chen, C., Monteiro, O., Buettner, S., Meyer, K., Bano, D., Radyushkin, K., Langston, R., Lambert, J.J., Wanker, E., Methner, A., Krauss, S., Schweiger, S. and Stroh, A.
eLife 7
: e38744.
4 September 2018
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells.
Trepte, P., Kruse, S., Kostova, S., Hoffmann, S., Buntru, A., Tempelmeier, A., Secker, C., Diez, L., Schulz, A., Klockmeier, K., Zenkner, M., Golusik, S., Rau, K., Schnoegl, S., Garner, C.C. and Wanker, E.E.
Molecular Systems Biology 14
(7): e8071.
11 July 2018
Reducing mutant huntingtin protein expression in living cells by a newly identified RNA CAG binder.
Matthes, F., Massari, S., Bochicchio, A., Schorpp, K., Schilling, J., Weber, S., Offermann, N., Desantis, J., Wanker, E.E., Carloni, P., Hadian, K., Tabarrini, O., Rossetti, G. and Krauss, S.
ACS Chemical Neuroscience 9
(6): 1399-1408.
20 June 2018
Self-assembly of mutant huntingtin exon-1 fragments into large complex fibrillar structures involves nucleated branching.
Wagner, A.S., Politi, A.Z., Ast, A., Bravo-Rodriguez, K., Baum, K., Buntru, A., Strempel, N.U., Brusendorf, L., Hänig, C., Boeddrich, A., Plassmann, S., Klockmeier, K., Ramirez-Anguita, J.M., Sanchez-Garcia, E., Wolf, J. and Wanker, E.E.
Journal of Molecular Biology 430
(12): 1725-1744.
8 June 2018
The CRISPR/Cas9 system sheds new lights on the biology of protozoan parasites.
Grzybek, M., Golonko, A., Górska, A., Szczepaniak, K., Strachecka, A., Lass, A. and Lisowski, P.
Applied Microbiology and Biotechnology 102
(11): 4629-4640.
June 2018
Mitochondria and the dynamic control of stem cell homeostasis.
Lisowski, P., Kannan, P., Mlody, B. and Prigione, A.
EMBO Reports 19
(5): e45432.
1 May 2018
Pluripotent stem cells for uncovering the role of mitochondria in human brain function and dysfunction.
Zink, A., Priller, J. and Prigione, A.
Journal of Molecular Biology 430
(7): 891-903.
30 March 2018
Inhibition of the MID1 protein complex: a novel approach targeting APP protein synthesis.
Matthes, F., Hettich, M.M., Schilling, J., Flores-Dominguez, D., Blank, N., Wiglenda, T., Buntru, A., Wolf, H., Weber, S., Vorberg, I., Dagane, A., Dittmar, G., Wanker, E., Ehninger, D. and Krauss, S.
Cell Death Discovery 4
: 4.
29 January 2018
Epigallocatechin gallate (EGCG) reduces the intensity of pancreatic amyloid fibrils in human islet amyloid polypeptide (hIAPP) transgenic mice.
Franko, A., Rodriguez Camargo, D.C., Böddrich, A., Garg, D., Rodriguez Camargo, A., Rathkolb, B., Janik, D., Aichler, M., Feuchtinger, A., Neff, F., Fuchs, H., Wanker, E.E., Reif, B., Häring, H.U., Peter, A. and Hrabě de Angelis, M.
Scientific Reports 8
(1): 1116.
18 January 2018
Complete suppression of Htt fibrilization and disaggregation of Htt fibrils by a trimeric chaperone complex.
Scior, A., Buntru, A., Arnsburg, K., Ast, A., Iburg, M., Juenemann, K., Pigazzini, M.L., Mlody, B., Puchkov, D., Priller, J., Wanker, E.E., Prigione, A. and Kirstein, J.
EMBO Journal 37
(2): 282-299.
17 January 2018
A novel RNA editing sensor tool and a specific agonist determine neuronal protein expression of RNA-edited glycine receptors and identify a genomic APOBEC1 dimorphism as a new genetic risk factor of epilepsy.
Kankowski, S., Förstera, B., Winkelmann, A., Knauff, P., Wanker, E.E., You, X.A., Semtner, M., Hetsch, F. and Meier, J.C.
Frontiers in Molecular Neuroscience 10
: 439.
11 January 2018
Human mesenchymal factors induce rat hippocampal- and human neural stem cell dependent oligodendrogenesis.
Jadasz, J.J., Tepe, L., Beyer, F., Samper Agrelo, I., Akkermann, R., Spitzhorn, L.S., Silva, M.E., Oreffo, R.O.C., Hartung, H.P., Prigione, A., Rivera, F.J., Adjaye, J. and Kuery, P.
Glia 66
(1): 145-160.
January 2018
A filter retardation assay facilitates the detection and quantification of heat-stable, amyloidogenic mutant huntingtin aggregates in complex biosamples.
Ast, A., Schindler, F., Buntru, A., Schnoegl, S. and Wanker, E.E.
Methods in Molecular Biology 1780
: 31-40.
2018
Engineering of human-induced pluripotent stem cells for precise disease modeling.
Lisowski, P.
In:
Stem Cell Genetics for Biomedical Research: Past, Present, and Future.
Springer, Cham, Switzerland, 369-411.
ISBN 978-3-319-90694-2
2018
2017
Mitochondrial metabolism in early neural fate and its relevance for neuronal disease modeling.
Lorenz, C. and Prigione, A.
Current Opinion in Cell Biology 49
: 71-76.
December 2017
Human SLFN5 is a transcriptional co-repressor of STAT1-mediated interferon responses and promotes the malignant phenotype in glioblastoma.
Arslan, A.D., Sassano, A., Saleiro, D., Lisowski, P., Kosciuczuk, E.M., Fischietti, M., Eckerdt, F., Fish, E.N. and Platanias, L.C.
Oncogene 36
(43): 6006-6019.
26 October 2017
Nijmegen Breakage Syndrome fibroblasts and iPSCs: cellular models for uncovering disease-associated signaling pathways and establishing a screening platform for anti-oxidants.
Mlody, B., Wruck, W., Martins, S., Sperling, K. and Adjaye, J.
Scientific Reports 7
(1): 7516.
8 August 2017
Concise review: Induced pluripotent stem cell-based drug discovery for mitochondrial disease.
Inak, G., Lorenz, C., Lisowski, P., Zink, A., Mlody, B. and Prigione, A.
Stem Cells 35
(7): 1655-1662.
July 2017
Gene editing and clonal isolation of human induced pluripotent stem cells using CRISPR/Cas9.
Yumlu, S., Stumm, J., Bashir, S., Dreyer, A.K., Lisowski, P., Danner, E. and Kühn, R.
Methods 121-122
: 29-44.
15 May 2017
Human iPSC-derived neural progenitors are an effective drug discovery model for neurological mtDNA disorders.
Lorenz, C., Lesimple, P., Bukowiecki, R., Zink, A., Inak, G., Mlody, B., Singh, M., Semtner, M., Mah, N., Auré, K., Leong, M., Zabiegalov, O., Lyras, E.M., Pfiffer, V., Fauler, B., Eichhorst, J., Wiesner, B., Huebner, N., Priller, J., Mielke, T., Meierhofer, D., Izsvák, Z., Meier, J.C., Bouillaud, F., Adjaye, J., Schuelke, M., Wanker, E.E., Lombès, A. and Prigione, A.
Cell Stem Cell 20
(5): 659-674.e9.
4 May 2017
Inhibition of huntingtin exon-1 aggregation by the molecular tweezer CLR01.
Vöpel, T., Bravo-Rodriguez, K., Mittal, S., Vachharajani, S., Gnutt, D., Sharma, A., Steinhof, A., Fatoba, O., Ellrichmann, G., Nshanian, M., Heid, C., Loo, J.A., Klärner, F.-G., Schrader, T., Bitan, G., Wanker, E.E., Ebbinghaus, S. and Sanchez-Garcia, E.
Journal of the American Chemical Society 139
(16): 5640-5643.
26 April 2017
Identification of an RNA polymerase III regulator linked to disease-associated protein aggregation.
Sin, O., de Jong, T., Mata-Cabana, A., Kudron, M., Zaini, M.A., Aprile, F.A., Seinstra, R.I., Stroo, E., Prins, R.W., Martineau, C.N., Wang, H.H., Hogewerf, Wytse, Steinhof, A., Wanker, E.E., Vendruscolo, M., Calkhoven, C.F., Reinke, V., Guryev, V. and Nollen, E.A.A.
Molecular Cell 65
(6): 1096-1108.
16 March 2017
The redox environment triggers conformational changes and aggregation of hIAPP in type II diabetes.
Rodriguez Camargo, D.C., Tripsianes, K., Buday, K., Franko, A., Göbl, C., Hartlmüller, C., Sarkar, R., Aichler, M., Mettenleiter, G., Schulz, M., Böddrich, A., Erck, C., Martens, H., Walch, A.K., Madl, T., Wanker, E.E., Conrad, M., de Angelis, M.H. and Reif, B.
Scientific Reports 7
: 44041.
13 March 2017
Epigenetics of cell fate reprogramming and its implications for neurological disorders modelling.
Grzybek, M., Golonko, A., Walczak, M. and Lisowski, P.
Neurobiology of Disease 99
: 84-120.
March 2017
Aggregation of full length immunoglobulin light chains from AL amyloidosis patients is remodeled by epigallocatechin-3-gallate.
Andrich, K., Hegenbart, U., Kimmich, C., Kedia, N., Bergen, H.R., Schönland, S., Wanker, E.E. and Bieschke, J.
Journal of Biological Chemistry 292
(6): 2328-2344.
10 February 2017
Aggregation-induced changes in the chemical exchange saturation transfer (CEST) signals of proteins.
Goerke, S., Milde, K.S., Bukowiecki, R., Kunz, P., Klika, K.D., Wiglenda, T., Mogk, A., Wanker, E.E., Bukau, B., Ladd, M.E., Bachert, P. and Zaiss, M.
NMR in Biomedicine 30
(1): e3665.
January 2017
2016
A movement disorder with dystonia and ataxia caused by a mutation in the HIBCH gene.
Schottmann, G., Sarpong, A., Lorenz, C., Weinhold, N., Gill, E., Teschner, L., Ferdinandusse, S., Wanders, R.J.A., Prigione, A. and Schuelke, M.
Movement Disorders 31
(11): 1733-1739.
November 2016
Age-dependent differential expression of death-associated protein 6 (Daxx) in various peripheral tissues and different brain regions of C57BL/6 male mice.
Lessard-Beaudoin, M., Laroche, M., Demers, M.J., Duclos, C., Denault, J.B., Grenier, G., Riechers, S.P., Wanker, E.E. and Graham, R.K.
Biogerontology 17
(5): 817-828.
November 2016
Organ-specific alteration in caspase expression and STK3 proteolysis during the aging process.
Lessard-Beaudoin, M., Laroche, M., Loudghi, A., Demers, M.J., Denault, J.B., Grenier, G., Riechers, S.P., Wanker, E.E. and Graham, R.K.
Neurobiology of Aging 47
: 50-62.
November 2016
Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers.
Arumughan, A., Roske, Y., Barth, C., Lleras Forero, L., Bravo-Rodriguez, K., Redel, Al., Kostova, S., McShane, E., Opitz, R., Faelber, K., Rau, K., Mielke, T., Daumke, O., Selbach, M., Sanchez-Garcia, E., Rocks, O., Panáková, D., Heinemann, U. and Wanker, E.E.
Nature Communications 7
: 13047.
20 October 2016
A glycolytic solution for pluripotent stem cells.
Mlody, B. and Prigione, A.
Cell Stem Cell 19
(4): 419-420.
6 October 2016
Immunoadsorption of agonistic autoantibodies against α1-adrenergic receptors in patients with mild to moderate dementia.
Hempel, P., Heinig, B., Jerosch, C., Decius, I., Karczewski, P., Kassner, U., Kunze, R., Steinhagen-Thiessen, E. and Bimmler, M.
Therapeutic Apheresis and Dialysis 20
(5): 523-529.
October 2016
Amyloid-β(1-42) aggregation initiates its cellular uptake and cytotoxicity.
Jin, S., Kedia, N., Illes-Toth, E., Haralampiev, I., Prisner, S., Herrmann, A., Wanker, E.E. and Bieschke, J.
Journal of Biological Chemistry 291
(37): 19590-19606.
9 September 2016
Aging vs. rejuvenation: reprogramming to iPSCs does not turn back the clock for somatic mitochondrial DNA mutations.
Lorenz, C. and Prigione, A.
Stem Cell Investigation 3
: 43.
September 2016
An integer programming framework for inferring disease complexes from network data.
Mazza, A., Klockmeier, K., Wanker, E. and Sharan, R.
Bioinformatics 32
(12): i271-i277.
15 June 2016
Functional characterisation of human synaptic genes expressed in the Drosophila brain.
Zografos, L., Tang, J., Hesse, F., Wanker, E.E., Li, K.W., Smit, A.B., Davies, R.W. and Armstrong, J.D.
Biology Open 5
(5): 662-667.
15 May 2016
Current approaches toward quantitative mapping of the interactome.
Buntru, A., Trepte, P., Klockmeier, K., Schnoegl, S. and Wanker, E.E.
Frontiers in Genetics 7
: 74.
4 May 2016
Interactome network analysis identifies multiple caspase-6 interactors involved in the pathogenesis of HD.
Riechers, S.P., Butland, S., Deng, Y., Skotte, N., Ehrnhoefer, D.E., Russ, J., Laine, J., Laroche, M., Pouladi, M.A., Wanker, E.E., Hayden, M.R. and Graham, R.K.
Human Molecular Genetics 25
(8): 1600-1618.
May 2016
Optimization of the All-D peptide D3 for Aβ oligomer elimination.
Klein, A.N., Ziehm, T., Tusche, M., Buitenhuis, J., Bartnik, D., Boeddrich, A., Wiglenda, T., Wanker, E., Funke, S.A., Brener, O., Gremer, L., Kutzsche, J. and Willbold, D.
PLoS ONE 11
(4): e0153035.
22 April 2016
A mitochondrial view of cell fate.
Prigione, A.
Seminars in Cell & Developmental Biology 52
: 66-67.
April 2016
Energy metabolism in neuronal/glial induction and iPSC-based modeling of brain disorders.
Mlody, B., Lorenz, C., Inak, G. and Prigione, A.
Seminars in Cell & Developmental Biology 52
: 102-109.
April 2016
Combined fluorescence and phosphorescence lifetime imaging.
Shcheslavskiy, V.I., Neubauer, A., Bukowiecki, R., Dinter, F. and Becker, W.
Applied Physics Letters 108
(9): 091111.
3 March 2016
Novel small molecules targeting ciliary transport of Smoothened and oncogenic Hedgehog pathway activation.
Jung, B., Messias, A.C., Schorpp, K., Geerlof, A., Schneider, G., Saur, D., Hadian, K., Sattler, M., Wanker, E.E., Hasenöder, S. and Lickert, H.
Scientific Reports 6
: 22540.
2 March 2016
Isolation and cultivation of naive-like human pluripotent stem cells based on HERVH expression.
Wang, J., Singh, M., Sun, C., Besser, D., Prigione, A., Ivics, Z., Hurst, L.D. and Izsvák, Z.
Nature Protocols 11
(2): 327-346.
February 2016
2015
Annexin A1 sustains tumor metabolism and cellular proliferation upon stable loss of HIF1A.
Rohwer, N., Bindel, F., Grimm, C., Lin, S.J., Wappler, J., Klinger, B., Blüthgen, N., Du Bois, I., Schmeck, B., Lehrach, H., de Graauw, M., Goncalves, E., Saez-Rodriguez, J., Tan, P., Grabsch, H.I., Prigione, A., Kempa, S. and Cramer, T.
Oncotarget 7
(6): 6693-6710.
29 December 2015
DULIP: A dual luminescence-based co-immunoprecipitation assay for interactome mapping in mammalian cells.
Trepte, P., Buntru, A., Klockmeier, K., Willmore, L., Arumughan, A., Secker, C., Zenkner, M., Brusendorf, L., Rau, K., Redel, A. and Wanker, E.E.
Journal of Molecular Biology 427
(21): 3375-3388.
23 October 2015
Corticotropin-releasing hormone receptor type 1 (CRHR1) clustering with MAGUKs is mediated via its C-terminal PDZ binding motif.
Bender, J., Engeholm, M., Ederer, M.S., Breu, J., Møller, T.C., Michalakis, S., Rasko, T., Wanker, E.E., Biel, M., Martinez, K.L., Wurst, W. and Deussing, J.M.
PLoS ONE 10
(9): e0136768.
9 September 2015
Reduced SNAP-25 increases PSD-95 mobility and impairs spine morphogenesis.
Fossati, G., Morini, R., Corradini, I., Antonucci, F., Trepte, P., Edry, E., Sharma, V., Papale, A., Pozzi, D., Defilippi, P., Meier, J.C., Brambilla, R., Turco, E., Rosenblum, K., Wanker, E.E., Ziv, N.E., Menna, E. and Matteoli, M.
Cell Death and Differentiation 22
(9): 1425-1436.
September 2015
The return of metabolism: biochemistry and physiology of the pentose phosphate pathway.
Stincone, A., Prigione, A., Cramer, T., Wamelink, M.M.C., Campbell, K., Cheung, E., Olin-Sandoval, V., Gruening, N.M., Krueger, A., Tauqeer Alam, M., Keller, M.A., Breitenbach, M., Brindle, K.M., Rabinowitz, J.D. and Ralser, M.
Biological Reviews 90
(3): 927-963.
August 2015
Quantitative interaction proteomics of neurodegenerative disease proteins.
Hosp, F., Vossfeldt, H., Heinig, M., Vasiljevic, D., Arumughan, A., Wyler, E., Landthaler, M., Hubner, N., Wanker, E.E., Lannfelt, L., Ingelsson, M., Lalowski, M., Voigt, A. and Selbach, M.
Cell Reports 11
(7): 1134-1146.
19 May 2015
Metabolic restructuring and cell fate conversion.
Prigione, A., Ruiz-Perez, M.V., Bukowiecki, R. and Adjaye, J.
Cellular and Molecular Life Sciences 72
(9): 1759-1777.
1 May 2015
Systematic interaction network filtering identifies CRMP1 as a novel suppressor of huntingtin misfolding and neurotoxicity.
Stroedicke, M., Bounab, Y., Strempel, N., Klockmeier, K., Yigit, S., Friedrich, R.P., Chaurasia, G., Li, S., Hesse, F., Riechers, S.P., Russ, J., Nicoletti, C., Boeddrich, A., Wiglenda, T., Haenig, C., Schnoegl, S., Fournier, D., Graham, R.K., Hayden, M.R., Sigrist, S., Bates, G.P., Priller, J., Andrade-Navarro, M.A., Futschik, M.E. and Wanker, E.E.
Genome Research 25
(5): 701-713.
May 2015
Central role of ULK1 in type I interferon signaling.
Saleiro, D., Mehrotra, S., Kroczynska, B., Beauchamp, E.M., Lisowski, P., Majchrzak-Kita, B., Bhagat, T.D., Stein, B.L., McMahon, B., Altman, J.K., Kosciuczuk, E.M., Baker, D.P., Jie, C., Jafari, N., Thompson, C.B., Levine, R.L., Fish, E.N., Verma, A.K. and Platanias, L.C.
Cell Reports 11
(4): 605-617.
28 April 2015
Modulation of human IAPP fibrillation: cosolutes, crowders and chaperones.
Gao, M., Estel, K., Seeliger, J., Friedrich, R.P., Dogan, S., Wanker, E.E., Winter, R. and Ebbinghaus, S.
Physical Chemistry Chemical Physics 17
(13): 8338-8348.
7 April 2015
In utero gene therapy rescues microcephaly caused by Pqbp1-hypofunction in neural stem progenitor cells.
Ito, H., Shiwaku, H., Yoshida, C., Homma, H., Luo, H., Chen, X., Fujita, K., Musante, L., Fischer, U., Frints, S.G.M., Romano, C., Ikeuchi, Y., Shimamura, T., Imoto, S., Miyano, S., Muramatsu, S.I., Kawauchi, T., Hoshino, M., Sudol, M., Arumughan, A., Wanker, E.E., Rich, T., Schwartz, C., Matsuzaki, F., Bonni, A., Kalscheuer, V.M. and Okazawa, H.
Molecular Psychiatry 20
(4): 459-471.
April 2015
Anti-inflammatory effects of atorvastatin treatment in chronic obstructive pulmonary disease. A controlled pilot study.
Mroz, R.M., Lisowski, P., Tycinska, A., Bierla, J., Trzeciak, P.Z., Minarowski, L., Milewski, R., Lisowska, A., Boros, P., Sobkowicz, B., Duszewska, A.M., Chyczewska, E., Musial, W.J. and MacNee, W.
Journal of Physiology and Pharmacology 66
(1): 111-128.
February 2015
Induced pluripotent stem cells (iPSCs) for modeling mitochondrial DNA disorders.
Prigione, A.
Methods in Molecular Biology 1265
: 349-356.
6 January 2015
The green tea polyphenol (-)-epigallocatechin gallate prevents the aggregation of tau protein into toxic oligomers at substoichiometric ratios.
Wobst, H.J., Sharma, A., Diamond, M.I., Wanker, E.E. and Bieschke, J.
FEBS Letters 589
(1): 77-83.
2 January 2015
Assessing the bioenergetic profile of human pluripotent stem cells.
Pfiffer, V. and Prigione, A.
Methods in Molecular Biology 1264
: 279-288.
2015
The effect of (-)-Epigallo-catechin-(3)-gallate on amyloidogenic proteins suggests a common mechanism.
Andrich, K. and Bieschke, J.
Advances in Experimental Medicine and Biology 863
: 139-161.
2015
2014
Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells.
Wang, J., Xie, G., Singh, M., Ghanbarian, A.T., Raskó, T., Szvetnik, A., Cai, H., Besser, D., Prigione, A., Fuchs, N.V., Schumann, G.G., Chen, W., Lorincz, M.C., Ivics, Z., Hurst, L.D. and Izsvák, Z.
Nature 516
(7531): 405-409.
18 December 2014
Social stress increases expression of hemoglobin genes in mouse prefrontal cortex.
Stankiewicz, A.M., Goscik, J., Swiergiel, A.H., Majewska, A., Wieczorek, M., Juszczak, G.R. and Lisowski, P.
BMC Neuroscience 15
(1): 130.
4 December 2014
The E3-ubiquitin ligase MID1 catalyzes ubiquitination and cleavage of Fu.
Schweiger, S., Dorn, S., Fuchs, M., Köhler, A., Matthes, F., Müller, E.C., Wanker, E., Schneider, R. and Krauß, S.
Journal of Biological Chemistry 289
(46): 31805-31817.
14 November 2014
Cupulin is a zona pellucida-like domain protein and major component of the cupula from the inner ear.
Dernedde, J., Weise, C., Mueller, E.C., Hagiwara, A., Bachmann, S., Suzuki, M., Reutter, W., Tauber, R. and Scherer, H.
PLoS ONE 9
(11): e111917.
4 November 2014
Identification of the mitochondrial MSRB2 as a binding partner of LG72.
Otte, D.M., Raskó, T., Wang, M., Dreiseidler, M., Drews, E., Schrage, H., Wojtalla, A., Höhfeld, J., Wanker, E. and Zimmer, A.
Cellular and Molecular Neurobiology 34
(8): 1123-1130.
November 2014
Characterizing protein interactions employing a genome-wide siRNA cellular phenotyping screen.
Suratanee, A., Schaefer, M.H., Betts, M.J., Soons, Z., Mannsperger, H., Harder, N., Oswald, M., Gipp, M., Ramminger, E., Marcus, G., Männer, R., Rohr, K., Wanker, E., Russell, R.B., Andrade-Navarro, M.A., Eils, R. and König, R.
PLoS Computational Biology 10
(9): e1003814.
25 September 2014
Prion-like proteins sequester and suppress the toxicity of huntingtin exon 1.
Kayatekin, C., Matlack, K.E.S., Hesse, W.R., Guan, Y., Chakrabortee, S., Russ, J., Wanker, E.E., Shah, J.V. and Lindquist, S.
Proceedings of the National Academy of Sciences of the United States of America 111
(33): 12085-12090.
19 August 2014
Spontaneous self-assembly of pathogenic huntingtin exon 1 protein into amyloid structures.
Trepte, P., Strempel, N. and Wanker, E.E.
Essays in Biochemistry 56
(1): 167-180.
18 August 2014
The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease.
Butland, S.L., Sanders, S.S., Schmidt, M.E., Riechers, S.P., Lin, D.T.S., Martin, D.D.O., Vaid, K., Graham, R.K., Singaraja, R.R., Wanker, E.E., Conibear, E. and Hayden, M.R.
Human Molecular Genetics 23
(15): 4142-4160.
1 August 2014
Evidence for the interaction of Endophilin A3 with endogenous K(Ca)2.3 channels in PC12 cells.
Janbein, M., Quader, M.A., Hoppner, A.C., Grüner, I., Wanker, E., Wälter, S., Küppers, E., Grissmer, S. and Jäger, H.
Cellular Physiology and Biochemistry 34
(2): 474-490.
30 July 2014
Polyglutamine-rich suppressors of huntingtin toxicity act upstream of hsp70 and sti1 in spatial quality control of amyloid-like proteins.
Wolfe, K.J., Ren, H.Y., Trepte, P. and Cyr, D.M.
PLoS ONE 9
(5): e95914.
14 May 2014
Annexin A2 mediates apical trafficking of renal Na(+)-K(+)-2Cl(-)-cotransporter.
Dathe, C., Daigeler, A.L., Seifert, W., Jankowski, V., Mrowka, R., Kalis, R., Wanker, E., Mutig, K., Bachmann, S. and Paliege, A.
Journal of Biological Chemistry 289
(14): 9983-9997.
4 April 2014
A mitochondrial strategy for safeguarding the reprogrammed genome.
Prigione, A. and Adjaye, J.
Cell Regeneration 3
(1): 5.
29 March 2014
HIF1α modulates reprogramming through early glycolytic shift and up-regulation of PDK1-3 and PKM2.
Prigione, A., Rohwer, N., Hoffman, S., Mlody, B., Drews, K., Bukowiecki, R., Bluemlein, K., Wanker, E.E., Ralser, M., Cramer, T. and Adjaye, J.
Stem Cells 32
(2): 364-376.
February 2014
Mitochondrial function in pluripotent stem cells and cellular reprogramming.
Bukowiecki, R., Adjaye, J. and Prigione, A.
Gerontology 60
(2): 174-182.
February 2014
2013
Myc inhibition impairs autophagosome formation.
Toh, P.P.C., Luo, S., Menzies, F.M., Raskó, T., Wanker, E.E. and Rubinsztein, D.C.
Human Molecular Genetics 22
(25): 5237-5248.
20 December 2013
The Hsp70/90 cochaperone, Sti1, suppresses proteotoxicity by regulating spatial quality control of amyloid-like proteins.
Wolfe, K.J., Ren, H.Y., Trepte, P. and Cyr, D.M.
Molecular Biology of the Cell 24
(23): 3588-3602.
December 2013
HDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration.
Mielcarek, M., Landles, C., Weiss, A., Bradaia, A., Seredenina, T., Inuabasi, L., Osborne, G.F., Wadel, K., Touller, C., Butler, R., Robertson, J., Franklin, S.A., Smith, D.L., Park, L., Marks, P.A., Wanker, E.E., Olson, E.N., Luthi-Carter, R., van der Putten, H., Beaumont, V. and Bates, G.P.
PLoS Biology 11
(11): e1001717.
November 2013
SUMO-2 and PIAS1 modulate insoluble mutant Huntingtin protein accumulation.
O'Rourke, J.G., Gareau, J.R., Ochaba, J., Song, W., Raskó, T., Reverter, D., Lee, J., Monteys, A.M., Pallos, J., Mee, L., Vashishtha, M., Apostol, B.L., Nicholson, T.P., Illes, K., Zhu, Y.Z., Dasso, M., Bates, G.P., Difiglia, M., Davidson, B., Wanker, E.E., Marsh, J.L., Lima, C.D., Steffan, J.S. and Thompson, L.M.
Cell Reports 4
(2): 362-375.
25 July 2013
Aggregation of polyQ-extended proteins is promoted by interaction with their natural coiled-coil partners.
Petrakis, S., Schaefer, M.H., Wanker, E.E. and Andrade-Navarro, M.A.
BioEssays 35
(6): 503-507.
June 2013
In vivo phosphorylation and in vitro autophosphorylation-inactivation of Kluyveromyces lactis hexokinase KlHxk1.
Kettner, K., Kuettner, E.B., Otto, A., Lilie, H., Golbik, R.P., Straeter, N. and Kriegel, T.M.
Biochemical and Biophysical Research Communications 435
(2): 313-318.
31 May 2013
A Y2H-seq approach defines the human protein methyltransferase interactome.
Weimann, M., Grossmann, A., Woodsmith, J., Özkan, Z., Birth, P., Meierhofer, D., Benlasfer, N., Valovka, T., Timmermann, B., Wanker, E.E., Sauer, S. and Stelzl, U.
Nature Methods 10
(4): 339-342.
April 2013
Dynamic circadian protein-protein interaction networks predict temporal organization of cellular functions.
Wallach, T, Schellenberg, K, Maier, B, Kalathur, R.K., Porras, P., Wanker, E.E., Futschik, M.E. and Kramer, A.
PLoS Genetics 9
(3): e1003398.
March 2013
Translation of HTT mRNA with expanded CAG repeats is regulated by the MID1-PP2A protein complex.
Krauss, S., Griesche, N., Jastrzebska, E., Chen, C., Rutschow, D., Achmüller, C., Dorn, S., Boesch, S.M., Lalowski, M., Wanker, E., Schneider, R. and Schweiger, S.
Nature Communications 4
: 1511.
26 February 2013
Epigallocatechin-3-gallate: a useful, effective and safe clinical approach for targeted prevention and individualised treatment of neurological diseases.
Mähler, A., Mandel, S., Lorenz, M., Ruegg, U., Wanker, E.E., Boschmann, M. and Paul, F.
EPMA Journal 4
(1): 5.
18 February 2013
Inhibitors of amyloid and oligomer formation.
Lorenzen, N., Wanker, E.E. and Otzen, D.
In:
Amyloid Fibrils and Prefibrillar Aggregates: Molecular and Biological Properties.
Wiley-VCH, Weinheim, 345-372.
ISBN 978-3-527-33200-7
12 February 2013
Development and application of a DNA microarray-based yeast two-hybrid system.
Suter, B., Fontaine, J.F., Yildirimman, R., Raskó, T., Schaefer, M.H., Rasche, A., Porras, P., Vázquez-Álvarez, B.M., Russ, J., Rau, K., Foulle, R., Zenkner, M., Saar, K., Herwig, R., Andrade-Navarro, M.A. and Wanker, E.E.
Nucleic Acids Research 41
(3): 1496-507.
1 February 2013
A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiple polyglutamine diseases.
Fujita, K., Nakamura, Y., Oka, T., Ito, H., Tamura, T., Tagawa, K., Sasabe, T., Katsuta, A., Motoki, K., Shiwaku, H., Sone, M., Yoshida, C., Katsuno, M., Eishi, Y., Murata, M., Taylor, J.P., Wanker, E.E., Kono, K., Tashiro, S., Sobue, G., La Spada, A.R. and Okazawa, H.
Nature Communications 4
: 1816.
2013
2012
Green tea halts progression of cardiac transthyretin amyloidosis: an observational report.
Kristen, A.V., Lehrke, S., Buss, S., Mereles, D., Steen, H., Ehlermann, P., Hardt, S., Giannitsis, E., Schreiner, R., Haberkorn, U., Schnabel, P.A., Linke, R.P., Roecken, C., Wanker, E.E., Dengler, T.J., Altland, K. and Katus, H.A.
Clinical Research in Cardiology 101
(10): 805-813.
October 2012
Structural properties of EGCG-induced, nontoxic Alzheimer's disease Aβ oligomers.
Lopez Del Amo, J.M., Fink, U., Dasari, M., Grelle, G., Wanker, E.E., Bieschke, J. and Reif, B.
Journal of Molecular Biology 421
(4-5): 517-524.
24 August 2012
Identification of human proteins that modify misfolding and proteotoxicity of pathogenic ataxin-1.
Petrakis, S., Rasko, T., Russ, J., Friedrich, R.P., Stroedicke, M., Riechers, S.P., Muehlenberg, K., Moeller, A., Reinhardt, A., Vinayagam, A., Schaefer, M.H., Boutros, M., Tricoire, H., Andrade-Navarro, M.A. and Wanker, E.E.
PLoS Genetics 8
(8): e1002897.
16 August 2012
Ahnak1 interaction is affected by phosphorylation of Ser-296 on Cavβ(2).
Pankonien, I., Otto, A., Dascal, N., Morano, I. and Haase, H.
Biochemical and Biophysical Research Communications 421
(2): 184-189.
4 May 2012
Evolution and function of CAG/polyglutamine repeats in protein-protein interaction networks.
Schaefer, M.H., Wanker, E.E. and Andrade-Navarro, M.A.
Nucleic Acids Research 40
(10): 4273-4287.
1 May 2012
Phosphorylation-regulated axonal dependent transport of syntaxin 1 is mediated by a Kinesin-1 adapter.
Chua, J.J.E., Butkevich, E., Worseck, J.M., Kittelmann, M., Gronborg, M., Behrmann, E., Stelzl, U., Pavlos, N.J., Lalowski, M.M., Eimer, S., Wanker, E.E., Klopfenstein, D.R. and Jahn, R.
Proceedings of the National Academy of Sciences of the United States of America 109
(15): 5862-5867.
10 April 2012
The SNF2-like helicase HELLS mediates E2F3-dependent transcription and cellular transformation.
von Eyss, B., Maaskola, J., Memczak, S., Möllmann, K., Schuetz, A., Loddenkemper, C., Tanh, M.D., Otto, A., Muegge, K., Heinemann, U., Rajewsky, N. and Ziebold, U.
EMBO Journal 31
(4): 972-985.
15 February 2012
HIPPIE: integrating protein interaction networks with experiment based quality scores.
Schaefer, M.H., Fontaine, J.F., Vinayagam, A., Porras, P., Wanker, E.E. and Andrade-Navarro, M.A.
PLoS ONE 7
(2): e31826.
14 February 2012
670 nm laser light and EGCG complementarily reduce amyloid-β aggregates in human neuroblastoma cells: basis for treatment of Alzheimer's disease?
Sommer, A.P., Bieschke, J., Friedrich, R.P., Zhu, D., Wanker, E.E., Fecht, H.J., Mereles, D. and Hunstein, W.
Photomedicine and Laser Surgery 30
(1): 54-60.
4 January 2012
Small-molecule conversion of toxic oligomers to nontoxic β-sheet-rich amyloid fibrils.
Bieschke, J., Herbst, M., Wiglenda, T., Friedrich, R.P., Boeddrich, A., Schiele, F., Kleckers, D., Lopez Del Amo, J.M., Gruening, B.A., Wang, Q., Schmidt, M.R., Lurz, R., Anwyl, R., Schnoegl, S., Faendrich, M., Frank, R.F., Reif, B., Guenther, S., Walsh, D.M. and Wanker, E.E.
Nature Chemical Biology 8
(1): 93-101.
January 2012
The investigation of binary PPIs with the classical yeast two-hybrid (Y2H) approach, Y2H variants, and other in vivo methods for PPI mapping.
Suter, B. and Wanker, E.E.
Methods in Molecular Biology 812
: v-vi.
2012
2011
The X-chromosome linked intellectual disability protein PQBP1 is a component of neuronal RNA granules and regulates the appearance of stress granules.
Kunde, S.A., Musante, L., Grimme, A., Fischer, U., Mueller, E., Wanker, E.E. and Kalscheuer, V.M.
Human Molecular Genetics 20
(24): 4916-4931.
15 December 2011
Black tea theaflavins inhibit formation of toxic amyloid-beta and alpha-synuclein fibrils.
Grelle, G., Otto, A., Lorenz, M., Frank, R.F., Wanker, E.E. and Bieschke, J.
Biochemistry 50
(49): 10624-10636.
13 December 2011
A novel multiplex cell viability assay for high-throughput RNAi screening.
Gilbert, D.F., Erdmann, G., Zhang, X., Fritzsche, A., Demir, K., Jaedicke, A., Muehlenberg, K., Wanker, E.E. and Boutros, M.
PLoS ONE 6
(12): e28338.
5 December 2011
Hemolytic porcine intestinal Escherichia coli without virulence-associated genes typical of intestinal pathogenic E. coli.
Schierack, P., Weinreich, J., Ewers, C., Tachu, B., Nicholson, B. and Barth, S.
Applied and Environmental Microbiology 77
(23): 8451-8455.
December 2011
Ku70 alleviates neurodegeneration in drosophila models of Huntington's disease.
Tamura, T., Sone, M., Iwatsubo, T., Tagawa, K., Wanker, E.E. and Okazawa, H.
PLoS ONE 6
(11): e27408.
7 November 2011
A directed protein interaction network for investigating intracellular signal transduction.
Vinayagam, A., Stelzl, U., Foulle, R., Plassmann, S., Zenkner, M., Timm, J., Assmus, H.E., Andrade-Navarro, M.A. and Wanker, E.E.
Science Signaling 4
(189): rs8.
6 September 2011
Detection of mutations by flow cytometric melting point analysis of PCR products.
Imre, L., Balogh, I., Kappelmayer, J., Szabó, M., Melegh, B., Wanker, E. and Szabó, G.
Cytometry Part A 79A
(9): 720-726.
September 2011
PTAA and B10: new approaches to amyloid detection in tissue-evaluation of amyloid detection in tissue with a conjugated polyelectrolyte and a fibril-specific antibody fragment.
Kieninger, B., Gioeva, Z., Krueger, S., Westermark, G.T., Friedrich, R.P., Faendrich, M. and Roecken, C.
Amyloid 18
(2): 47-52.
June 2011
E. coli Nissle 1917 Affects Salmonella Adhesion to Porcine Intestinal Epithelial Cells.
Schierack, P., Kleta, S., Tedin, K., Babila, J.T., Oswald, S., Oelschlaeger, T.A., Hiemann, R., Paetzold, S. and Wieler, L.H.
PLoS ONE 6
(2): e14712.
17 February 2011
Bacterial inclusion bodies of Alzheimer's disease beta-amyloid peptides can be employed to study native-like aggregation intermediate states.
Dasari, M., Espargaro, A., Sabate, R., Lopez Del Amo, J.M., Fink, U., Grelle, G., Bieschke, J., Ventura, S. and Reif, B.
ChemBioChem 12
(3): 407-423.
11 February 2011
Yeast hexokinase isoenzyme ScHxk2: stability of a two-domain protein with discontinuous domains.
Lilie, H., Baer, D., Kettner, K., Weininger, U., Balbach, J., Naumann, M., Mueller, E.C., Otto, A., Gast, K., Golbik, R. and Kriegel, T.
Protein Engineering Design and Selection 24
(1-2): 79-87.
January 2011
2010
Crystal structure of hexokinase KlHxk1 of Kluyveromyces lactis: a molecular basis for understanding the control of yeast hexokinase functions via covalent modification and oligomerization.
Kuettner, E.B., Kettner, K., Keim, A., Svergun, D.I., Volke, D., Singer, D., Hoffmann, R., Mueller, E.C., Otto, A., Kriegel, T.M. and Straeter, N.
Journal of Biological Chemistry 285
(52): 41019-41033.
24 December 2010
Gruener Tee - neue Einsichten fuer einen alten Wirkstoff [Green tea - new insights for an old drug].
Bieschke, J.
Chemie in unserer Zeit 44
(4): 306-307.
August 2010
Inferring modules from human protein interactome classes.
Marras, E., Travaglione, A., Chaurasia, G., Futschik, M. and Capobianco, E.
BMC Systems Biology 4
: 105.
23 July 2010
Mutant huntingtin impairs Ku70-mediated DNA repair.
Enokido, Y., Tamura, T., Ito, H., Arumughan, A., Komuro, A., Shiwaku, H., Sone, M., Foulle, R., Sawada, H., Ishiguro, H., Ono, T., Murata, M., Kanazawa, I., Tomilin, N., Tagawa, K., Wanker, E.E. and Okazawa, H.
Journal of Cell Biology 189
(3): 425-443.
3 May 2010
EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity.
Bieschke, J., Russ, J., Friedrich, R.P., Ehrnhoefer, D.E., Wobst, H., Neugebauer, K. and Wanker, E.E.
Proceedings of the National Academy of Sciences of the United States of America 107
(17): 7710-7715.
27 April 2010
Structure and function of yeast glutaredoxin 2 depend on postranslational processing and are related to subcellular distribution.
Porras, P., McDonagh, B., Pedrajas, J.R., Barcena, J.A. and Padilla, C.A.
Biochimica et Biophysica Acta - Proteins and Proteomics 1804
(4): 839-845.
April 2010
Pathogenic polyglutamine tracts are potent inducers of spontaneous sup35 and rnq1 amyloidogenesis.
Goehler, H., Droege, A., Lurz, R., Schnoegl, S., Chernoff, Y.O. and Wanker, E.E.
PLoS ONE 5
(3): e9642.
10 March 2010
Repeated two-hybrid screening detects transient protein-protein interactions.
Vinayagam, A., Stelzl, U. and Wanker, E.E.
Theoretical Chemistry Accounts 125
(3-6): 613-619.
March 2010
The coxsackievirus-adenovirus receptor reveals complex homophilic and heterophilic interactions on neural cells.
Patzke, C., Max, K.E., Behlke, J., Schreiber, J., Schmidt, H., Dorner, A.A., Kroeger, S., Henning, M., Otto, A., Heinemann, U. and Rathjen, F.G.
Journal of Neuroscience 30
(8): 2897-2910.
24 February 2010
2009
Polyglutamine expansion in huntingtin increases its insertion into lipid bilayers.
Kegel, K.B., Schewkunow, V., Sapp, E., Masso, N., Wanker, E.E., Difiglia, M. and Goldmann, W.H.
Biochemical and Biophysical Research Communications 387
(3): 472-475.
25 September 2009
Novel roles of Hakai in cell proliferation and oncogenesis.
Figueroa, A., Kotani, H., Toda, Y., Mazan-Mamczarz, K., Mueller, E.C., Otto, A., Disch, L., Norman, M., Ramdasi, R., Keshtgar, M., Gorospe, M. and Fujita, Y.
Molecular Biology of the Cell 20
(15): 3533-3542.
August 2009
Evaluation of the possible transmission of BSE and scrapie to gilthead sea bream (Sparus aurata).
Salta, E., Panagiotidis, C., Teliousis, K., Petrakis, S., Eleftheriadis, E., Arapoglou, F., Grigoriadis, N., Nicolaou, A., Kaldrymidou, E., Krey, G. and Sklaviadis, T.
PLoS ONE 4
(7): e6175.
28 July 2009
Detection of alpha-rod protein repeats using a neural network and application to huntingtin.
Palidwor, G.A., Shcherbinin, S., Huska, M.R., Rasko, T., Stelzl, U., Arumughan, A., Foulle, R., Porras, P., Sanchez-Pulido, L., Wanker, E.E. and Andrade-Navarro, M.A.
PLoS Computational Biology 5
(3): e1000304.
13 March 2009
Transferrin-receptor-mediated iron accumulation controls proliferation and glutamate release in glioma cells.
Chirasani, S.R., Markovic, D.S., Synowitz, M., Eichler, S.A., Wisniewski, P., Kaminska, B., Otto, A., Wanker, E., Schaefer, M., Chiarugi, P., Meier, J.C., Kettenmann, H. and Glass, R.
Journal of Molecular Medicine 87
(2): 153-167.
February 2009
Glial cell lineage expression of mutant ataxin-1 and huntingtin induces developmental and late-onset neuronal pathologies in drosophila models.
Tamura, T., Sone, M., Yamashita, M., Wanker, E.E. and Okazawa, H.
PLoS ONE 4
(1): e4262.
23 January 2009
An empirical framework for binary interactome mapping.
Venkatesan, K., Rual, J.F., Vazquez, A., Stelzl, U., Lemmens, I., Hirozane-Kishikawa, T., Hao, T., Zenkner, M., Xin, X., Goh, K.I., Yildirim, M.A., Simonis, N., Heinzmann, K., Gebreab, F., Sahalie, J.M., Cevik, S., Simon, C., de Smet, A.S., Dann, E., Smolyar, A., Vinayagam, A., Yu, H., Szeto, D., Borick, H., Dricot, A., Klitgord, N., Murray, R.R., Lin, C., Lalowski, M., Timm, J., Rau, K., Boone, C., Braun, P., Cusick, M.E., Roth, F.P., Hill, D.E., Tavernier, J., Wanker, E.E., Barabasi, A.L. and Vidal, M.
Nature Methods 6
(1): 83-90.
January 2009
Cleft lip and/or palate with monogenic autosomal recessive transmission in Pyrenees shepherd dogs.
Kemp, C., Thiele, H., Dankof, A., Schmidt, G., Lauster, C., Fernahl, G. and Lauster, R.
Cleft Palate-Craniofacial Journal 46
(1): 81-88.
January 2009
UniHI 4: new tools for query, analysis and visualization of the human protein-protein interactome.
Chaurasia, G., Malhotra, S., Russ, J., Schnoegl, S., Haenig, C., Wanker, E.E. and Futschik, M.E.
Nucleic Acids Research 37
(Database Issue): D657-D660.
January 2009
2008
A fluorescent two-hybrid (F2H) assay for direct visualization of protein interactions in living cells.
Zolghadr, K., Mortusewicz, O., Rothbauer, U., Kleinhans, R., Goehler, H., Wanker, E.E., Cardoso, M.C. and Leonhardt, H.
Molecular and Cellular Proteomics 7
(11): 2279-2287.
1 November 2008
Bell's palsy: combined treatment of famciclovir and prednisone is superior to prednisone alone.
Minnerop, M., Herbst, M., Fimmers, R., Matz, B., Klockgether, T. and Wuellner, U.
Journal of Neurology 255
(11): 1726-1730.
November 2008
Identification and characterization of CaApe2 – a neutral arginine/alanine/leucine-specific metallo-aminopeptidase from Candida albicans.
Klinke, T., Rump, A., Poenisch, R., Schellenberger, W., Mueller, E.C., Otto, A., Klimm, W. and Kriegel, T.M.
FEMS Yeast Research 8
(6): 858-869.
September 2008
Comparative 3'UTR analysis allows identification of regulatory clusters that drive Eph/ephrin expression in cancer cell lines.
Winter, J., Roepcke, S., Krause, S., Mueller, E.C., Otto, A., Vingron, M. and Schweiger, S.
PLoS ONE 3
(7): e2780.
23 July 2008
Omi / HtrA2 is relevant to the selective vulnerability of striatal neurons in Huntington's disease.
Inagaki, R., Tagawa, K., Qi, M.L., Enokido, Y., Ito, H., Tamura, T., Shimizu, S., Oyanagi, K., Arai, N., Kanazawa, I., Wanker, E.E. and Okazawa, H.
European Journal of Neuroscience 28
(1): 30-40.
July 2008
EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers.
Ehrnhoefer, D.E., Bieschke, J., Boeddrich, A., Herbst, M., Masino, L., Lurz, R., Engemann, S., Pastore, A. and Wanker, E.E.
Nature Structural & Molecular Biology 15
(6): 558-566.
June 2008
Therapy effects of green tea in a patient with systemic light-chain amyloidosis.
Mereles, D., Wanker, E.E. and Katus, H.A.
Clinical Research in Cardiology 97
(5): 341-344.
May 2008
The Opitz syndrome gene product MID1 assembles a microtubule-associated ribonucleoprotein complex.
Aranda-Orgilles, B., Trockenbacher, A., Winter, J., Aigner, J., Koehler, A., Jastrzebska, E., Stahl, J., Mueller, E.C., Otto, A., Wanker, E.E., Schneider, R. and Schweiger, S.
Human Genetics 123
(2): 163-176.
March 2008
Alpha-synuclein selectively binds to anionic phospholipids embedded in liquid-disordered domains.
Stoeckl, M., Fischer, P., Wanker, E.E. and Herrmann, A.
Journal of Molecular Biology 375
(5): 1394-1404.
1 February 2008
Structure-function analysis of the filamentous actin binding domain of the neuronal scaffolding protein spinophilin.
Schueler, H. and Peti, W.
FEBS Journal 275
(1): 59-68.
January 2008
Actin/myosin-based gliding motility in apicomplexan parasites.
Matuschewski, K. and Schueler, H.
Subcellular Biochemistry 47
(47): 110-120.
2008
2007
Identification and characterization of a novel glucose-phosphorylating enzyme in Kluyveromyces lactis.
Kettner, K., Mueller, E.C., Otto, A., Roedel, G., Breunig, K.D. and Kriegel, T.M.
FEMS Yeast Research 7
(5): 683-692.
August 2007
Small molecule inducers of heat-shock response reduce polyQ-mediated huntingtin aggregation. A possible therapeutic strategy.
Herbst, M. and Wanker, E.E.
Neurodegenerative Diseases 4
(2-3): 254-260.
June 2007
Proteome analysis of soluble nuclear proteins reveals that HMGB1/2 suppress genotoxic stress in polyglutamine diseases.
Qi, M.L., Tagawa, K., Enokido, Y., Yoshimura, N., Wada, Y.I., Watase, K., Ishiura, S.I., Kanazawa, I., Botas, J., Saitoe, M., Wanker, E.E. and Okazawa, H.
Nature Cell Biology 9
(4): 402-414.
April 2007
Comparison of human protein-protein interaction maps.
Futschik, M.E., Chaurasia, G. and Herzel, H.
Bioinformatics 23
(5): 605-611.
March 2007
Flexible web-based integration of distributed large-scale human protein interaction maps.
Chaurasia, G., Iqbal, Y., Haenig, C., Herzel, H., Wanker, E.E. and Futschik, M.E.
Journal of Integrative Bioinformatics 4
(1): 51.
26 February 2007
Crystal structure of human inosine triphosphatase: Substrate binding and implication of the itpa deficiency mutation p32T.
Stenmark, P., Kursula, P., Flodin, S., Graeslund, S., Landry, R., Nordlund, P. and Schueler, H.
Journal of Biological Chemistry 282
(5): 3182-3187.
2 February 2007
Pathological consequences of VCP mutations on human striated muscle.
Huebbers, C.U., Clemen, C.S., Kesper, K., Boeddrich, A., Hofmann, A., Kaemaeraeinen, O., Tolksdorf, K., Stumpf, M., Reichelt, J., Roth, U., Krause, S., Watts, G., Kimonis, V., Wattjes, M.P., Reimann, J., Thal, D.R., Biermann, K., Evert, B.O., Lochmueller, H., Wanker, E.E., Schoser, B.G., Noegel, A.A. and Schroeder, R.
Brain 130
(2): 381-393.
1 February 2007
The induction levels of heat shock protein 70 differentiate the vulnerabilities to mutant huntingtin among neuronal subtypes.
Tagawa, K., Marubuchi, S., Qi, M.L., Enokido, Y., Tamura, T., Inagaki, R., Murata, M., Kanazawa, I., Wanker, E.E. and Okazawa, H.
Journal of Neuroscience 27
(4): 868-880.
24 January 2007
Self-association of adrenodoxin studied by using analytical ultracentrifugation.
Behlke, J., Ristau, O., Mueller, E.C., Hannemann, F. and Bernhardt, R.
Biophysical Chemistry 125
(1): 159-165.
January 2007
UniHI: an entry gate to the human protein interactome.
Chaurasia, G., Iqbal, Y., Haenig, C., Herzel, H., Wanker, E.E. and Futschik, M.E.
Nucleic Acids Research 35
(Database Issue): D590-D594.
January 2007
2006
The collapsin response mediator protein 1 (CRMP-1) and the promyelocytic leukemia zinc finger protein (PLZF) bind to UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE), the key enzyme of sialic acid biosynthesis.
Weidemann, W., Stelzl, U., Lisewski, U., Bork, K., Wanker, E.E., Hinderlich, S. and Horstkorte, R.
FEBS Letters 580
(28): 6649-6654.
11 December 2006
The value of high quality protein-protein interaction networks for systems biology.
Stelzl, U. and Wanker, E.E.
Current Opinion in Chemical Biology 10
(6): 551-558.
December 2006
Plant nitric oxide synthase: a never-ending story?
Zemojtel, T., Froehlich, A., Palmieri, M.C., Kolanczyk, M., Mikula, I., Wyrwicz, L.S., Wanker, E.E., Mundlos, S., Vingron, M., Martasek, P. and Durner, J.
Trends Plant Sci 11
(11): 524-525.
November 2006
Regulation of apicomplexan microfilament dynamics by a minimal set of actin-binding proteins.
Schueler, H. and Matuschewski, K.
Traffic 7
(11): 1433-1439.
November 2006
Novel drugs and diagnostic compositions for use in the treatment and diagnosis of neurodegenerative diseases or amyloid diseases [Neue Arzneimittel und diagnostische Zusammensetzungen fuer die Behandlung und Diagnose von neurodegenerativen Erkrankungen und Amyloid-Krankheiten].
Wanker, E.E., Engemann, S., Rautenberg, S., Boeddrich, A., Harjes, P., Litscher, D., Herbst, M. and Walther, J.
EP1713457 ; WO0577343.
25 October 2006
Analytical model of peptide mass cluster centres with applications.
Wolski, W.E., Farrow, M., Emde, A.K., Lehrach, H., Lalowski, M. and Reinert, K.
Proteome Science 4
: 18.
23 September 2006
Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models.
Ehrnhoefer, D.E., Duennwald, M., Markovic, P., Wacker, J.L., Engemann, S., Roark, M., Legleiter, J., Marsh, J.L., Thompson, L.M., Lindquist, S., Muchowski, P.J. and Wanker, E.E.
Human Molecular Genetics 15
(18): 2743-2751.
15 September 2006
Potassium channel dysfunction and depolarized resting membrane potential in a cell model of SCA3.
Jeub, M., Herbst, M., Spauschus, A., Fleischer, H., Klockgether, T., Wuellner, U. and Evert, B.O.
Exp Neurol 201
(1): 182-192.
1 September 2006
Huntingtin interacts with the receptor sorting family protein GASP2.
Horn, S.C., Lalowski, M., Goehler, H., Droege, A., Wanker, E.E. and Stelzl, U.
Journal of Neural Transmission 113
(8): 1081-1090.
August 2006
Method for the identification of protein-protein interactions in disease related protein networks [Verfahren zur Identifizierung von Protein-Protein-Wechselwirkungen in krankheitsbezogenen Proteinnetzwerken].
Wanker, E.E., Lalowski, M., Stelzl, U., Stroedicke, M., Haenig, C., Worm, U. and Goehler, H.
EP1677113.
5 July 2006
Structure of the synthetase domain of human CTP synthetase, a target for anticancer therapy.
Kursula, P., Flodin, S., Ehn, M., Hammarstroem, M., Schueler, H., Nordlund, P. and Stenmark, P.
Acta Crystallographica Section F 62
(7): 613-617.
1 July 2006
Genomic analysis of Xenopus organizer function.
Hufton, A.L., Vinayagam, A., Suhai, S. and Baker, J.C.
BMC Developmental Biology 6
: 27.
6 June 2006
Complexes of syndapin II with dynamin II promote vesicle formation at the trans-Golgi network.
Kessels, M.M., Dong, J., Leibig, W., Westermann, P. and Qualmann, B.
Journal of Cell Science 119
(8): 1504-1516.
15 April 2006
An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis.
Boeddrich, A., Gaumer, S., Haacke, A., Tzvetkov, N., Albrecht, M., Evert, B.O., Mueller, E.C., Lurz, R., Breuer, P., Schugardt, N., Plassmann, S., Xu, K., Warrick, J.M., Suopanki, J., Wuellner, U., Frank, R., Hartl, U.F., Bonini, N.M. and Wanker, E.E.
EMBO Journal 25
(7): 1547-1558.
5 April 2006
Plasmodium motility: actin not actin' like actin.
Schueler, H. and Matuschewski, K.
Trends in Parasitology 22
(4): 146-147.
April 2006
Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73.
Hoshino, M., Qi, M.L., Yoshimura, N., Miyashita, T., Tagawa, K., Wada, Y.I., Enokido, Y., Marubuchi, S., Arai, P., Arai, N., Oyanagi, K., Blandino, G., Sudol, M., Rich, T., Kanazawa, I., Wanker, E.E., Saitoe, M. and Okazawa, H.
Journal of Cell Biology 172
(4): 589-604.
13 February 2006
Identification of VCP/p97, CHIP and amphiphysin II interaction partners using membrane-based human proteome arrays.
Grelle, G., Kostka, S., Otto, A., Kersten, B., Genser, K.F., Mueller, E.C., Waelter, S., Boeddrich, A., Stelzl, U., Haenig, C., Volkmer-Engert, R., Landgraf, C., Alberti, S., Hoehfeld, J., Stroedicke, M. and Wanker, E.E.
Molecular & Cellular Proteomics 5
(2): 234-244.
1 February 2006
Interaction of huntingtin fragments with brain membranes - clues to early dysfunction in Huntington's disease.
Suopanki, J., Goetz, C., Lutsch, G., Schiller, J., Harjes, P., Herrmann, A. and Wanker, E.E.
Journal of Neurochemistry 96
(3): 870-884.
February 2006
Low stability of huntington muscle mitochondria against Ca2+ in R6/2 mice.
Gizatullina, Z.Z., Lindenberg, K.S., Harjes, P., Chen, Y., Kosinski, C.M., Landwehrmeyer, B.G., Ludolph, A.C., Striggow, F., Zierz, S. and Gellerich, F.N.
Annals of Neurology 59
(2): 407-411.
February 2006
Evaluation of the benzothiazole aggregation inhibitors riluzole and PGL-135 as therapeutics for Huntington's disease.
Hockly, E., Tse, J., Barker, A.L., Moolman, D.L., Beunard, J.L., Revington, A.P., Holt, K., Sunshine, S., Moffitt, H., Sathasivam, K., Woodman, B., Wanker, E.E., Lowden, P.A. and Bates, G.P.
Neurobiology of Disease 21
(1): 228-236.
January 2006
Protein-Wechselwirkungsnetzwerke: Aufklaerung der Funktion von Proteinen.
Stelzl, U. and Wanker, E.E.
Biologie in unserer Zeit 36
(1): 12-13.
January 2006
Mass spectrometry: ESI.
Mueller, E.C.
In:
Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine ; Vol. 2.
Springer, Berlin [u.a.], 1020-1022.
ISBN 3-540-44244-8
2006
Recombinant protein production in mammalian cell culture.
Droege, A.
In:
Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine ; Vol. 2.
Springer, Berlin [u.a.], 1616-1620.
ISBN 3-540-44244-8
2006
Systematic functional assessment of human protein-protein interaction maps.
Chaurasia, G., Herzel, H., Wanker, E.E. and Futschik, M.E.
Genome Inform 17
: 36-45.
2006
The connection between actin ATPase and polymerization.
Schueler, H., Karlsson, R., Schutt, C.E. and Lindberg, U.
Advances in Molecular and Cell Biology 37
: 49-66.
2006
Therapeutic approaches to polyglutamine diseases: combating protein misfolding and aggregation.
Herbst, M. and Wanker, E.E.
Current Pharmaceutical Design 12
(20): 2543-2555.
2006
2005
Transformation and other factors of the peptide mass spectrometry pairwise peak-list comparison process.
Wolski, W.E., Lalowski, M., Martus, P., Herwig, R., Giavalisco, P., Gobom, J., Sickmann, A., Lehrach, H. and Reinert, K.
BMC Bioinformatics 6
: 285.
30 November 2005
Method for qualitative comparisons of protein mixtures based on enzyme-catalyzed stable-isotope incorporation.
Mirgorodskaya, E., Wanker, E.E., Otto, A., Lehrach, H. and Gobom, J.
Journal of Proteome Research 4
(6): 2109-2116.
1 November 2005
Molecular analysis of the interaction between cardosin A and phospholipase Dalpha.
Simoes, I., Mueller, E.C., Otto, A., Bur, D., Cheung, A.Y., Faro, C. and Pires, E.
FEBS Journal 272
(22): 5786-5798.
1 November 2005
A human protein-protein interaction network: a resource for annotating the proteome.
Stelzl, U., Worm, U., Lalowski, M., Haenig, C., Brembeck, F.H., Goehler, H., Stroedicke, M., Zenkner, M., Schoenherr, A., Koeppen, S., Timm, J., Mintzlaff, S., Abraham, C., Bock, N., Kietzmann, S., Goedde, A., Toksoez, E., Droege, A., Krobitsch, S., Korn, B., Birchmeier, W., Lehrach, H. and Wanker, E.E.
Cell 122
(6): 957-968.
23 September 2005
Ataxin-2 and huntingtin interact with endophilin-A complexes to function in plastin-associated pathways.
Ralser, M., Nonhoff, U., Albrecht, M., Lengauer, T., Wanker, E.E., Lehrach, H. and Krobitsch, S.
Human Molecular Genetics 14
(19): 2893-2909.
22 August 2005
Calibration of mass spectrometric peptide mass fingerprint data without specific external or internal calibrants.
Wolski, W.E., Lalowski, M., Jungblut, P. and Reinert, K.
BMC Bioinformatics 6
: 203.
15 August 2005
Generation of a yeast two-hybrid strain suitable for competitive protein binding analysis.
Ralser, M., Goehler, H., Wanker, E.E., Lehrach, H. and Krobitsch, S.
Biotechniques 39
(2): 165-168.
1 August 2005
Multiplex approaches in protein microarray technology.
Kersten, B., Wanker, E.E., Hoheisel, J.D. and Angenendt, P.
Expert Review of Proteomics 2
(4): 499-510.
1 August 2005
Parkin interacts with the proteasome subunit alpha4.
Daechsel, J.C., Luecking, C.B., Deeg, S., Schultz, E., Lalowski, M., Casademunt, E., Corti, O., Hampe, C., Patenge, N., Vaupel, K., Yamamoto, A., Dichgans, M., Brice, A., Wanker, E.E., Kahle, P.J. and Gasser, T.
FEBS Letters 579
(18): 3913-3919.
18 July 2005
High-throughput identification of potential Arabidopsis MAP kinases substrates.
Feilner, T., Hultschig, C., Lee, J., Meyer, S., Immink, R.G., Koenig, A., Possling, A., Seitz, H., Beveridge, A., Scheel, D., Cahill, D.J., Lehrach, H., Kreutzberger, J. and Kersten, B.
Molecular & Cellular Proteomics 4
(10): 1558-1568.
11 July 2005
Nuclear oncoprotein prothymosin alpha is a partner of Keap1: implications for expression of oxidative stress-protecting genes.
Karapetian, R.N., Evstafieva, A.G., Abaeva, I.S., Chichkova, N.V., Filonov, G.S., Rubtsov, Y.P., Sukhacheva, E.A., Melnikov, S.V., Schneider, U., Wanker, E.E. and Vartapetian, A.B.
Molecular and Cellular Biology 25
(3): 1089-1099.
1 February 2005
A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo.
Zhang, X., Smith, D.L., Meriin, A.B., Engemann, S., Russel, D.E., Roark, M., Washington, S.L., Maxwell, M.M., Marsh, J.L., Thompson, L.M., Wanker, E.E., Young, A.B., Housman, D.E., Bates, G.P., Sherman, M.Y. and Kazantsev, A.G.
Proceedings of the National Academy of Sciences of the United States of America 102
(3): 892-897.
18 January 2005
Cerebral embolism from left atrial myxoma leading to cerebral and retinal aneurysms: A case report.
Herbst, M., Wattjes, M.P., Urbach, H., Inhetvin-Hutter, C., Becker, D., Kjockgether, T. and Hartmann, A.
American Journal of Neuroradiology 26
(3): 666-669.
1 January 2005
Characterization of mouse myotilin and its promoter.
Mologni, L., Moza, M., Lalowski, M.M. and Carpen, O.
Biochemical and Biophysical Research Communications 329
(3): 1001-1009.
1 January 2005
PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation.
Yu, M., Schreek, S., Cerni, C., Schamberger, C., Lesniewicz, K., Poreba, E., Vervoorts, J., Walsemann, G., Groetzinger, J., Kremmer, E., Mehraein, Y., Mertsching, J., Kraft, R., Austen, M., Luscher-Firzlaff, J. and Luescher, B.
Oncogene 24
(12): 1982-1993.
1 January 2005
Sulfur dehydrogenase of Paracoccus pantotrophus: The heme-2 domain of the molybdoprotein cytochrome c complex is dispensable for catalytic activity.
Bardischewsky, F., Quentmeier, A., Rother, D., Hellwig, P., Kostka, S. and Friedrich, C.G.
Biochemistry 44
(18): 7024-7034.
1 January 2005
2004
Disease related protein network [Proteinnetzwerk, das im Zusammenhang mit einer Krankheit steht].
Wanker, E.E., Lehrach, H., Goehler, H., Stroedicke, M., Stelzl, U. and Lalowski, M.
EP1636362 ; WO04113566.
29 December 2004
A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease.
Goehler, H., Lalowski, M., Stelzl, U., Waelter, S., Stroedicke, M., Worm, U., Droege, A., Lindenberg, K.S., Knoblich, M., Haenig, C., Herbst, M., Suopanki, J., Scherzinger, E., Abraham, C., Bauer, B., Hasenbank, R., Fritzsche, A., Ludewig, A.H., Buessow, K., Coleman, S.H., Gutekunst, C.A., Landwehrmeyer, B.G., Lehrach, H. and Wanker, E.E.
Molecular Cell 15
(6): 853-865.
24 September 2004
Domain specific characteristics of the bifunctional key enzyme of sialic acid biosynthesis, UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase.
Blume, A., Weidemann, W., Stelzl, U., Wanker, E.E., Lucka, L., Donner, P., Reutter, W., Horstkorte, R. and Hinderlich, S.
Biochemical Journal 384
(3): 599-607.
26 August 2004
Huntingtin bodies sequester vesicle-associated proteins by a polyproline-dependent interaction.
Qin, Z.H., Wang, Y., Sapp, E., Cuiffo, B., Wanker, E., Hayden, M.R., Kegel, K.B., Aronin, N. and DiFiglia, M.
Journal of Neuroscience 7
(1): 269-281.
7 January 2004
A molecular pathogenesis for transcription factor associated poly-alanine tract expansions.
Albrecht, A.N., Kornak, U., Boeddrich, A., Suering, K., Robinson, P.N., Stiege, A.C., Lurz, R., Stricker, S., Wanker, E.E. and Mundlos, S.
Human Molecular Genetics 13
(20): 2351-2359.
1 January 2004
Action and reaction: Chlamydophila pneumoniae proteome alteration in a persistent infection induced by iron deficiency.
Wehrl, W., Meyer, T.F., Jungblut, P.R., Mueller, E.C. and Szczepek, A.J.
Proteomics 4
(10): 2969-2981.
1 January 2004
Biochemical and proteomic analysis of the magnetosome membrane in Magnetospitillum gryphiswaldense.
Gruenberg, K., Mueller, E.C., Otto, A., Reszka, R., Linder, D., Kube, M., Reinhardt, R. and Schueler, D.
Applied and Environmental Microbiology 70
(2): 1040-1050.
1 January 2004
CFP10 discriminates between nonacetylated and acetylated ESAT-6 of Mycobacterium tuberculosis by differential interaction.
Okkels, L.M., Mueller, E.C., Schmid, M., Rosenkrands, I., Kaufmann, S.H.E., Andersen, P. and Jungblut, P.R.
Proteomics 4
(10): 2954-2960.
1 January 2004
Distinct aggregation and cell death patterns among different types of primary neurons induced by mutant huntingtin protein.
Tagawa, K., Hoshino, M., Okuda, T., Ueda, H., Hayashi, H., Engemann, S., Okado, H., Ichikawa, M., Wanker, E.E. and Okazawa, H.
Journal of Neurochemistry 89
(4): 974-987.
1 January 2004
Grossfahndung nach Hemmstoffen : Huntington-Forschung in Deutschland.
Schnoegl, S. and Wanker, E.E.
Spektrum der Wissenschaft 1
: 64-65.
1 January 2004
Molecular and physiological characterisation of a 3-phytase from soil bacterium Klebsiella sp. ASR1.
Sajidan, A., Farouk, A., Greiner, R., Jungblut, P., Mueller, E.C. and Borriss, R.
Applied Microbiology and Biotechnology 65
(1): 110-118.
1 January 2004
The adrenodoxin-like ferredoxin of Schizosaccharomyces pombe mitochondria.
Schiffler, B., Bureik, M., Reinle, W., Mueller, E.C., Hannemann, F. and Bernhardt, R.
Journal of Inorganic Biochemistry 98
(7): 1229-1237.
1 January 2004
The interaction of protein kinase C isozymes α, ι, and θ with the cytoplasmic domain of L-selectin is modulated by phosphorylation of the receptor.
Kilian, K., Dernedde, J., Mueller, E.C., Bahr, I. and Tauber, R.
Journal of Biological Chemistry 279
(33): 34472-34480.
1 January 2004
Grossfahndung nach Hemmstoffen.
Wanker, E.E. and Schnoegl, S.
Spektrum der Wissenschaft
(1): 64-65.
January 2004
2003
Mutant huntingtin promotes the fibrillogenesis of wild-type huntingtin - A potential mechanism for loss of huntingtin function in Huntington's disease.
Busch, A., Engemann, S., Lurz, R., Okazawa, H., Lehrach, H. and Wanker, E.E.
Journal of Biological Chemistry 278
(42): 41452-41461.
17 October 2003
The unique hexokinase of Kluyveromyces lactis - Molecular and functional characterization and evaluation of a role in glucose signaling.
Baer, D., Golbik, R., Huebner, G., Lilie, H., Mueller, E.C., Naumann, M., Otto, A., Reuter, R., Breunig, K.D. and Kriegel, T.M.
Journal of Biological Chemistry 278
(41): 39280-39286.
10 October 2003
The hunt for huntingtin function: interaction partners tell many different stories.
Harjes, P. and Wanker, E.E.
Trends in Biochemical Sciences 28
(8): 425-433.
August 2003
Proteomic and postproteomic characterization of keratan sulfate-glycanated isoforms of thyroglobulin and transferrin uniquely elaborated by papillary thyroid carcinomas.
Magro, G., Perissinotto, D., Schiappacassi, M., Goletz, S., Otto, A., Mueller, E.C., Bisceglia, M., Brown, G., Ellis, T., Grasso, S., Colombatti, A. and Perris, R.
American Journal of Pathology 163
(1): 183-196.
July 2003
Essential role of the apolipoprotein E receptor-2 in sperm development.
Andersen, O.M., Yeung, C.H., Vorum, H., Wellner, M., Andreassen, T.K., Erdmann, B., Mueller, E.C., Herz, J., Otto, A., Cooper, T.G. and Willnow, T.E.
Journal of Biological Chemistry 278
(26): 23989-23995.
27 June 2003
Verfahren zur Isolierung von Neuronen.
Pfrieger, F.W. and Naegler, K.
DE10155130A1.
22 May 2003
Mittel zur Behandlung von Laesionen des Nervensystems [Agents for treating lesions of the nervous system].
Pfrieger, F.W., Mauch, D., Goeritz, C. and Naegler, K.
DE10154221A1 ; EP1443941 ; WO0339555.
15 May 2003
Cloning, sequencing and recombinant expression of the open reading frame encoding a novel member of the Sarcocystis muris (Apicomplexa) microneme lectin family.
Klein, H., Mueller, S., Loeschner, B., Toenjes, R.R., Braun, G., Mueller, E.C., Otto, A. and Montag, T.
Parasitology Research 90
(1): 84-86.
May 2003
Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing.
Odintsova, T.I., Mueller, E.C., Ivanov, A.V., Egorov, T.A., Bienert, R., Vladimirov, S.N., Kostka, S., Otto, A., Wittmann-Liebold, B. and Karpova, G.G.
Journal of Protein Chemistry 22
(3): 249-258.
April 2003
Identification and characterization of the autophosphorylation sites of phosphoinositide 3-kinase isoforms beta and gamma.
Czupalla, C., Culo, M., Mueller, E.C., Brock, C., Reusch, H.P., Spicher, K., Krause, E. and Nuernberg, B.
Journal of Biological Chemistry 278
(13): 11536-11545.
28 March 2003
Neuron culture medium and use of cholesterol for cultivating, differentiating or proliferating neurons [Neues Medium zur Kultivierung von Nervenzellen].
Pfrieger, F.W. and Naegler, K.
DE10204747A1 ; WO0325160.
27 March 2003
Inhibitors of PolyQ-Aggregation [Hemmer der Aggregation von PolyQ].
Boettcher, H., Herhaus, C., Barnickel, G., Wanker, E.E., Heiser, V., Lehrach, H., Broeker, W. and Dunkel, I.
WO03015772 ; EP1416931.
27 February 2003
Affinity purification of ARE-binding proteins identifies polyA-binding protein 1 as a potential substrate in MK2-induced mRNA stabilization.
Bollig, F., Winzen, R., Gaestel, M., Kostka, S., Resch, K. and Holtmann, H.
Biochemical and Biophysical Research Communications 301
(3): 665-670.
14 February 2003
Polyglutamine fibrillogenesis: The pathway unfolds.
Ross, C.A., Poirier, M.A., Wanker, E.E. and Amzel, M.
Proceedings of the National Academy of Sciences of the United States of America 100
(1): 1-3.
7 January 2003
Comparative proteome analysis of culture supernatant proteins from virulent Mycobacterium tuberculosis H37Rv and attenuated M-bovis BCG Copenhagen.
Mattow, J., Schaible, U.E., Schmidt, F., Hagens, K., Siejak, R., Brestrich, G., Haeselbarth, G., Mueller, E.C., Jungblut, P.R. and Kaufmanni, S.H.E.
Electrophoresis 24
(19-20): 3405-3420.
1 January 2003
Histone deacetylase activity is retained in primary neurons expressing mutant huntingtin protein.
Hoshino, M., Tagawa, K., Okuda, T., Murata, M., Oyanagi, K., Arai, N., Mizutani, T., Kanazawa, I., Wanker, E.E. and Okazawa, H.
Journal of Neurochemistry 87
(1): 257-267.
1 January 2003
Lithostathine quadruple-helical filaments form proteinase K-resistant deposits in Creutzfeldt-Jakob disease.
Laurine, E., Gregoire, C., Faendrich, M., Engemann, S., Marchal, S., Thion, L., Mohr, M., Monsarrat, B., Michel, B., Dobson, C.M., Wanker, E.E., Erard, M. and Verdier, J.M.
Journal of Biological Chemistry 278
(51): 51770-51778.
1 January 2003
RNA-structural mimicry in Escherichia coli ribosomal protein L4-dependent regulation of the S10 operon.
Stelzl, U., Zengel, J.M., Tovbina, M., Walker, M., Nierhaus, K.H., Lindahl, L. and Patel, D.J.
Journal of Biological Chemistry 278
(30): 28237-28245.
1 January 2003
Identification of nuclear proteins of small cell lung cancer cell line H82: An improved procedure for the analysis of silver-stained proteins.
Gonzalez, L.J., Castellanos-Serra, L., Badock, V., Diaz, M., Moro, A., Perea, S., Santos, A., Paz-Lago, D., Otto, A., Mueller, E.C., Kostka, S., Wittmann-Liebold, B. and Padron, G.
Electrophoresis 24
(1-2): 237-252.
January 2003
Huntingtin fragments form aggresome-like inclusion bodies in mammalian cells.
Boeddrich, A., Lurz, R. and Wanker, E.E.
Methods in Molecular Biology 232
: 217-229.
2003
2002
Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington's disease by using an automated filter retardation assay.
Heiser, V., Engemann, S., Broecker, W., Dunkel, I., Boeddrich, A., Waelter, S., Nordhoff, E., Lurz, R., Schugardt, N., Rautenberg, S., Herhaus, C., Barnickel, G., Boettcher, H., Lehrach, H. and Wanker, E.E.
Proceedings of the National Academy of Sciences of the United States of America 99
(Suppl 4): 16400-16406.
10 December 2002
Compounds that inhibit HSP90 and stimulate HSP70 and HSP40, useful in the prevention or treatment of diseases associated with protein aggregation and amyloid formation [Verbindungen,die HSP90 stimulieren und HSP70 und HSP40 inhibieren, und deren Verwendung zur Prophylaxis und Behandlung von Krankheiten, die mit Protein-Aggregation und mit Amyloid-Bildung verbunden sind].
Wanker, E.E., Sittler, A. and Hartl, U.
WO02094259A1 ; EP1387678 ; US60/288,718.
28 November 2002
Exportin-5-mediated nuclear export of eukaryotic elongation factor 1A and tRNA.
Calado, A., Treichel, N., Mueller, E.C., Otto, A. and Kutay, U.
EMBO Journal 21
(22): 6216-6224.
15 November 2002
EcoRII: a restriction enzyme evolving recombination functions.
Muecke, M., Grelle, G., Behlke, J., Kraft, R., Krueger, D.H. and Reuter, M.
EMBO Journal 21
(19): 5262-5268.
1 October 2002
The Trichoderma atroviride seb1 (stress response element binding) gene encodes an AGGGG-binding protein which is involved in the response to high osmolarity stress.
Peterbauer, C.K., Litscher, D. and Kubicek, C.P.
Molecular Genetics and Genomics 268
(2): 223-231.
October 2002
Intermolecular electron transfer in cytochrome P450cam covalently bound with Tris(2,2'-bipyridyl)ruthenium(II): structural changes detected by FTIR spectroscopy.
Contzen, J., Kostka, S., Kraft, R. and Jung, C.
Journal of Inorganic Biochemistry 91
(4): 607-617.
20 September 2002
Generalized crystal-storing histiocytosis associated with monoclonal gammopathy: molecular analysis of a disorder with rapid clinical course and review of the literature.
Lebeau, A., Zeindl-Eberhart, E., Mueller, E.C., Mueller-Hoecker, J., Jungblut, P.R., Emmerich, B. and Loehrs, U.
Blood 100
(5): 1817-1827.
1 September 2002
System zur automatischen Isolierung von lebenden Zellen aus tierischen Geweben [System for automatically isolating living cells from animal tissue].
Pfrieger, F.W.
DE10116155A1 ; WO0266598.
29 August 2002
Counting CAG repeats in the Huntington's disease gene by restriction endonuclease EcoP15I cleavage.
Moencke-Buchner, E., Reich, S., Muecke, M., Reuter, M., Messer, W., Wanker, E.E. and Krueger, D.H.
Nucleic Acids Research 30
(16): e83.
15 August 2002
Phosphorylation by protein kinase CK2: A signaling switch for the caspase-inhibiting protein ARC.
Li, P.F., Li, J.C., Mueller, E.C., Otto, A., Dietz, R. and von Harsdorf, R.
Molecular Cell 10
(2): 247-258.
August 2002
Detection of cathepsin B up-regulation in neoplastic thyroid tissues by proteomic analysis.
Srisomsap, C., Subhasitanont, P., Otto, A., Mueller, E.C., Punyarit, P., Wittmann-Liebold, B. and Svasti, J.
Proteomics 2
(6): 706-712.
17 June 2002
Asymmetric photocross-linking pattern of restriction endonuclease EcoRII to the DNA recognition sequence.
Muecke, M., Pingoud, V., Grelle, G., Kraft, R., Krueger, D.H. and Reuter, M.
Journal of Biological Chemistry 277
(16): 14288-14293.
19 April 2002
Aggregation of proteins with expanded glutamine and alanine repeats of the glutamine-rich and asparagine-rich domains of Sup35 and of the amyloid β-peptide of amyloid plaques.
Perutz, M.F., Pope, B.J., Owen, D., Wanker, E.E. and Scherzinger, E.
Proceedings of the National Academy of Sciences of the United States of America 99
(8): 5596-5600.
16 April 2002
The synpolydactyly homolog (spdh) mutation in the mouse -- a defect in patterning and growth of limb cartilage elements.
Albrecht, A.N., Schwabe, G.C., Stricker, S., Boeddrich, A., Wanker, E.E. and Mundlos, S.
Mechanisms of Development 112
: 53-67.
1 March 2002
Hip1 and Hippi participate in a novel cell death-signaling pathway.
Wanker, E.E.
Developmental Cell 2
(2): 126-128.
February 2002
2001
Inhibition of polyglutamine aggregation in R6/2 HD brain slices-complex dose-response profiles.
Smith, D.L., Portier, R., Woodman, B., Hockly, E., Mahal, A., Klunk, W.E., Li, X.J., Wanker, E.E., Murray, K.D. and Bates, G.P.
Neurobiology of Diseases 8
: 1017-1026.
1 December 2001
CNS synaptogenesis promoted by glia-derived cholesterol.
Mauch, D.H., Naegler, K., Schumacher, S., Goeritz, C., Mueller, E.C., Otto, A. and Pfrieger, F.W.
Science 294
(5545): 1354-1357.
9 November 2001
Protein kinase C regulates the phosphorylation and cellular localization of occludin.
Andreeva, A.Y., Krause, E., Mueller, E.C., Blasig, I.E. and Utepbergenov, D.I.
Journal of Biological Chemistry 276
(42): 38480-38486.
19 October 2001
Centrosome disorganization in fibroblast cultures derived from R6/2 Huntington's disease (HD) transgenic mice and HD patients.
Sathasivam, K., Woodman, B., Mahal, A., Bertaux, F., Wanker, E.E., Shima, D.T. and Bates, G.P.
Human Molecular Genetics 10
: 2425-2435.
1 October 2001
The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis.
Waelter, S., Scherzinger, E., Hasenbank, R., Nordhoff, E., Lurz, R., Goehler, H., Gauss, C., Sathasivam, K., Bates, G.P., Lehrach, H. and Wanker, E.E.
Human Molecular Genetics 10
: 1807-1817.
15 August 2001
Heparin-bindende Proteine aus Gliazellen, analoge Proteine, sie kodierende Nukleinsaeuren und ihre Verwendung zum Nachweis und/oder zur Behandlung von Laesionen des Zentralnervensystems.
Pfrieger, F.W., Schumacher, S. and Mauch, D.
DE19959934A1.
13 June 2001
Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease.
Sittler, A., Lurz, R., Lueder, G., Priller, J., Lehrach, H., Hayer-Hartl, M.K., Hartl, F.U. and Wanker, E.E.
Human Molecular Genetics 10
: 1307-1315.
1 June 2001
Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation.
Waelter, S., Boeddrich, A., Lurz, R., Scherzinger, E., Lueder, G., Lehrach, H. and Wanker, E.E.
Molecular Biology of the Cell 12
(5): 1393-1407.
May 2001
Tyrosine phosphorylation patterns and size modification of the Helicobacter pyori CagA protein after translocation into gastric epithelial cells.
Backert, S., Mueller, E.C., Jungblut, P.R. and Meyer, T.F.
Proteomics 1
(4): 608-617.
April 2001
Apoptosis-induced cleavage of keratin 15 and keratin 17 in a human breast epithelial cell line.
Badock, V., Steinhusen, U., Bommert, K., Wittmann-Liebold, B. and Otto, A.
Cell Death and Differentiation 8
(3): 308-315.
1 March 2001
Analysis of mouse beta-haptoglobin chain by lectin affinoblotting detection.
Roemer, I., Vogel, T., Otto, A., Fichtner, I. and Klose, J.
Electrophoresis 22
: 3038-3042.
1 January 2001
Assignment of the huntingtin (Hdh) gene, the huntingtin associated protein (Hap1) gene, and the huntingtin interacting protein (Hip1) gene to rat chromosomes 14, 10, and 12 by radiation hybrid mapping and fluorescent in situ hybridization.
Zimdahl, H., Goesele, C., Luetjens, G., Gruetzner, F., Kreitler, T., Voss, K., Wanker, E.E. and Knoblauch, M.
Cytogenetics and Cell Genetics 94
: 101-104.
1 January 2001
COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system.
Bech-Otschir, D., Kraft, R., Huang, X.H., Henklein, P., Kapelari, B., Pollmann, C. and Dubiel, W.
EMBO Journal 20
(7): 1630-1639.
1 January 2001
Characterization and crystallization of a novel Sarcocystis muris lectin, SML-2.
Mueller, J.J., Mueller, E.C., Montag, T., Zyto, N., Loeschner, B., Klein, H., Heineman, U. and Otto, A.
Acta Crystallographica Section D 57
(7): 1042-1045.
1 January 2001
Covalently crosslinked complexes of bovine adrenodoxin with adrenodoxin reductase and cytochrome P450scc. Mass spectrometry and Edman degradation of complexes of the steroidogenic hydroxylase system.
Mueller, E.C., Lapko, A., Otto, A., Mueller, J.J., Ruckpaul, K. and Heinemann, U.
European Journal of Biochemistry 268
(6): 1837-1843.
1 January 2001
Defined sequence segments of the small heat shock proteins HSP25 and alphaB-crystallin inhibit actin polymerization.
Wieske, M., Benndorf, R., Behlke, J., Doelling, R., Grelle, G., Bielka, H. and Lutsch, G.
European Journal of Biochemistry 268
(7): 2083-2090.
1 January 2001
Glyceraldehyde-3-phosphate dehydrogenase is responsible for intranuclear localization of some oligonucleotides.
Tomasi, V., Laktionov, P.P., Bryksin, A.V., Volod'ko, N.V., Griffoni, C., Rykova, E.V., Spisni, E., Kraft, R. and Vlassov, V.V.
Nucleosides Nucleotides & Nucleic Acids 20
: 863-867.
1 January 2001
Human monoclonal rheumatoid synovial B Lymphocyte hybridoma with a new disease-related specificity for cartilage oligomeric matrix protein.
Souto-Carneiro, M.M., Burkhardt, H., Mueller, E.C., Hermann, R., Otto, A., Kraetsch, H.G., Sack, U., Koenig, A., Heinegard, D., Muller-Hermelink, H.K. and Krenn, V.
Journal of Immunology 166
: 4202-4208.
1 January 2001
Identification of acidic, low molecular mass proteins of Mycobacterium tuberculosis strain H37Rv by matrix-assisted laser desorption/ionization and electrospray ionization mass spectrometry.
Mattow, J., Jungblut, P.R., Mueller, E.C. and Kaufmann, S.H.E.
Proteomics 1
(4): 494-507.
1 January 2001
Identification of nucleolin as a new L-selectin ligand.
Harms, G., Kraft, R., Grelle, G., Volz, B., Dernedde, J. and Tauber, R.
Biochemical Journal 360
: 531-538.
1 January 2001
Identification of proteins from Mycobacterium tuberculosis missing in attenuated Mycobacterium bovis BCG strains.
Mattow, J., Jungblut, P.R., Schaible, U.E., Mollenkopf, H.J., Lamer, S., Zimny-Arndt, U., Hagens, K., Mueller, E.C. and Kaufmann, S.H.E.
Electrophoresis 22
: 2936-2946.
1 January 2001
Importin 13: a novel mediator of nuclear import and export.
Mingot, J.M., Kostka, S., Kraft, R., Hartmann, E. and Goerlich, D.
EMBO Journal 20
: 3685-3694.
1 January 2001
Multiple pathways contribute to nuclear import of core histones.
Muehlhaeusser, P., Mueller, E.C., Otto, A. and Kutay, U.
EMBO Reports 2
(8): 690-696.
1 January 2001
Prefractionation of protein samples for proteome analysis using reversed-phase high-performance liquid chromatography.
Badock, V., Steinhusen, U., Bommert, K. and Otto, A.
Electrophoresis 22
(14): 2856-2864.
1 January 2001
Proteomics reveals open reading frames in Mycobacterium tuberculosis H37Rv not predicted by genomics.
Jungblut, P.R., Mueller, E.C., Mattow, J. and Kaufmann, S.H.E.
Infection and Immunity 69
: 5905-5907.
1 January 2001
Regulation of phosphotransferase activity of hexokinase 2 from Saccharomyces cerevisiae by modification at serine-14.
Golbik, R., Naumann, M., Otto, A., Mueller, E.C., Behlke, J., Reuter, R. and Kriegel, T.M.
Biochemistry 40
(4): 1083-1090.
1 January 2001
Sm protein-Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure.
Urlaub, H., Raker, V.A., Kostka, S. and Luehrmann, R.
EMBO Journal 20
(1-2): 187-196.
1 January 2001
The Rossmann fold of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a nuclear docking site for antisense oligonucleotides containing a TAAAT motif.
Griffoni, C., Laktionov, P.P., Rykova, E.Y., Spisni, E., Riccio, M., Santi, S., Bryksin, A., Volodko, N., Kraft, R., Vlassov, V. and Tomasi, V.
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 1530
(1): 32-46.
1 January 2001
The nuclear orphan receptor TR4 promotes proliferation of myeloid progenitor cells.
Koritschoner, N.P., Madruga, J., Knespel, S., Blendinger, G., Anzinger, B., Otto, A., Zenke, M. and Bartunek, P.
Cell Growth and Differentiation 12
(11): 563-572.
1 January 2001
Deactivation of regulatory proteins hnRNP A1 and A2 during SC-1 induced apoptosis.
Hermann, R., Hensel, F., Mueller, E.C., Keppler, M., Souto-Carneiro, M., Braendlein, S., Mueller-Hermelink, H.K. and Vollmers, H.P.
Human Antibodies 10
(2): 83-90.
2001
2000
Protein aggregation in Huntington's and Parkinson's disease: implications for therapy.
Wanker, E.E.
Molecular Medicine Today 6
: 387-391.
1 October 2000
Novel genes coding for lithotrophic sulfur oxidation of Paracoccus pantotrophus GB17.
Friedrich, C.G., Quentmeier, A., Bardischewsky, F., Rother, D., Kraft, R., Kostka, S. and Prinz, H.
Journal of Bacteriology 182
: 4677-4687.
1 September 2000
Protein aggregation and pathogenesis of Huntington's disease: mechanisms and correlations.
Wanker, E.E.
Biological Chemistry 381
: 937-942.
1 September 2000
Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes.
Lipowsky, G., Bischoff, F.R., Schwarzmaier, P., Kraft, R., Kostka, S., Hartmann, E., Kutay, U. and Goerlich, D.
EMBO Journal 19
: 4362-4371.
15 August 2000
TNF-alpha-mediated neutrophil apoptosis involves Ly-GDI, a Rho GTPase regulator.
Kettritz, R., Xu, Y.X., Faass, B., Klein, J.B., Mueller, E.C., Otto, A., Busjahn, A., Luft, F.C. and Haller, H.
Journal of Leukocyte Biology 68
: 277-283.
1 August 2000
Profilin I attached to the Golgi is required for the formation of constitutive transport vesicles at the trans-Golgi network.
Dong, J., Radau, B., Otto, A., Mueller, E.C., Lindschau, C. and Westermann, P.
Biochimica et Biophysica Acta - Molecular Cell Research 1497
(2): 253-260.
21 July 2000
Overexpression of the proteasome subunits LMP2, LMP7, and MECL-1, but not PA28 alpha/beta, enhances the presentation of an immunodominant lymphocytic choriomeningitis virus T cell epitope.
Schwarz, K., van den Broek, M., Kostka, S., Kraft, R., Soza, A., Schmidtke, G., Kloetzel, P.M. and Groettrup, M.
Journal of Immunology 165
(2): 768-778.
15 July 2000
Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils.
Muchowski, P.J., Schaffar, G., Sittler, A., Wanker, E.E., Hayer-Hartl, M.K. and Hartl, F.U.
Proceedings of the National Academy of Sciences of the United States of America 97
(14): 7841-7846.
5 July 2000
Protein kinase Calpha-dependent phosphorylation of golgi proteins.
Radau, B., Otto, A., Mueller, E.C. and Westermann, P.
Electrophoresis 21
: 2684-2687.
1 July 2000
The selective proteasome inhibitors lactacystin and epoxomicin can be used to either up- or down-regulate antigen presentation at nontoxic doses.
Schwarz, K., de Giuli, R., Schmidtke, G., Kostka, S., van den Broek, M., Kim, K.B., Crews, C.M., Kraft, R. and Groettrup, M.
Journal of Immunology 164
(12): 6147-6157.
15 June 2000
Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: implications for Huntington's disease therapy.
Heiser, V., Scherzinger, E., Boeddrich, A., Nordhoff, E., Lurz, R., Schugardt, N., Lehrach, H. and Wanker, E.E.
Proceedings of the National Academy of Sciences of the United States of America 97
(12): 6739-6744.
6 June 2000
The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription.
Steffan, J.S., Kazantsev, A., Spasic-Boskovic, O., Greenwald, M., Zhu, Y.Z., Gohler, H., Wanker, E.E., Bates, G.P., Housman, D.E. and Thompson, L.M.
Proceedings of the National Academy of Sciences of the United States of America 97
: 6763-6768.
6 June 2000
Mammalian Sec61 is associated with Sec62 and Sec63.
Meyer, H.A., Grau, H., Kraft, R., Kostka, S., Prehn, S., Kalies, K.U. and Hartmann, E.
Journal of Biological Chemistry 275
(19): 14550-14557.
12 May 2000
Phosphorylation of Oct-2 at sites located in the POU domain induces differential down-regulation of Oct-2 DNA-binding ability.
Pevzner, V., Kraft, R., Kostka, S. and Lipp, M.
Biochemical Journal 347
(1): 29-35.
1 April 2000
GDP dissociation inhibitor D4-GDI (Rho-GDI 2), but not the homologous Rho-GDI 1, is cleaved by caspase-3 during drug-induced apoptosis.
Essmann, F., Wieder, T., Otto, A., Mueller, E.C., Doerken, B. and Daniel, P.T.
Biochemical Journal 346
(3): 777-783.
15 March 2000
Biochemical analysis of proteasomes from mouse microglia: Induction of immunoproteasomes by interferon-gamma and lipopolysaccharide.
Stohwasser, R., Giesebrecht, J., Kraft, R., Mueller, E.C., Haeusler, K.G., Kettenmann, H., Hanisch, U.K. and Kloetzel, P.M.
Glia 29
(4): 355-365.
15 February 2000
Characterization of a new type of sulfite dehydrogenase from Paracoccus pantotrophus GB17.
Quentmeier, A., Kraft, R., Kostka, S., Klockenkaemper, R. and Friedrich, C.G.
Archives of Microbiology 173
(2): 117-125.
1 February 2000
A general approach for identification of RNA-Protein cross-linking sites within native human spliceosomal small nuclear ribonucleoproteins (snRNPs) - Analysis of RNA-protein contacts in native U1 and U4/U6.U5 snRNPs.
Urlaub, H., Hartmuth, K., Kostka, S., Grelle, G. and Luehrmann, R.
Journal of Biological Chemistry 275
(52): 41458-41468.
1 January 2000
Interaction between interferon consensus sequence-binding protein and COP9/signalosome subunit CSN2 (Trip15) - A possible link between interferon regulatory factor signaling and the COP9/signalosome.
Cohen, H., Azriel, A., Cohen, T., Meraro, D., Hashmueli, S., Bech-Otschir, D., Kraft, R., Dubiel, W. and Levi, B.Z.
Journal of Biological Chemistry 275
(50): 39081-39089.
1 January 2000
Investigation of apoptosis-involved processes by mass spectrometric identification of the apoptosis-associated proteins in IgM-induced burkitt lymphoma cells.
Mueller, E.C., Wittmann-Liebold, B. and Otto, A.
In:
Mass Spectrometry in Biology and Medicine.
Humana Press, Totowa, 271-287.
ISBN 0-89603-799-1
1 January 2000
1999
Folding of oligoglutamines: a theoretical approach based upon thermodynamics and molecular mechanics.
Starikov, E.B., Lehrach, H. and Wanker, E.E.
Journal of Biomolecular Structure & Dynamics 17
: 409-427.
1 December 1999
Signaling from beta-adrenoceptor to L-type calcium channel: identification of a novel cardiac protein kinase A target possessing similarities to AHNAK.
Haase, H., Podzuweit, T., Lutsch, G., Hohaus, A., Kostka, S., Lindschau, C., Kott, M., Kraft, R. and Morano, I.
FASEB Journal 13
(15): 2161-2172.
December 1999
T-cell-activating monoclonal antibodies, reacting with both leukocytes and erythrocytes, recognize the guinea pig Thy-1 differentiation antigen: Characterization and cloning of guinea pig CD90.
Schaefer, H., Bartels, T., Hahn, G., Otto, A. and Burger, R.
Cellular Immunology 197
(2): 116-128.
1 November 1999
Megalin knockout mice as an animal model of low molecular weight proteinuria.
Leheste, J.R., Rolinski, B., Vorum, H., Hilpert, J., Nykjaer, A., Jacobsen, C., Aucouturier, P., Moskaug, J.O., Otto, A., Christensen, E.I. and Willnow, T.E.
American Journal of Pathology 155
(4): 1361-1370.
1 October 1999
The base of the proteasome regulatory particle exhibits chaperone-like activity.
Braun, B.C., Glickman, M., Kraft, R., Dahlmann, B., Kloetzel, P.M., Finley, D. and Schmidt, M.
Nature Cell Biology 1
(4): 221-226.
1 August 1999
Cyanophycinase, a peptidase degrading the cyanobacterial reserve material multi-L-arginyl-poly-L-aspartic acid (cyanophycin) - Molecular cloning of the gene of Synechocystis sp PCC 6803, expression in Escherichia coli, and biochemical characterization of the purified enzyme.
Richter, R., Hejazi, M., Kraft, R., Ziegler, K. and Lockau, W.
European Journal of Biochemistry 263
: 163-169.
1 July 1999
Proteomics in human disease: cancer,heart and infectious diseases.
Jungblut, P.R., Zimny-Arndt, U., Zeindl-Eberhart, E., Stulik, J., Koupilova, K., Pleissner, K.P., Otto, A., Mueller, E.C., Sokolowska-Koehler, W., Grabher, G. and Stoeffler, G.
Electrophoresis 20
(10): 2100-2110.
July 1999
Aggregation of truncated GST-HD exon 1 fusion proteins containing normal range and expanded glutamine repeats.
Hollenbach, B., Scherzinger, E., Schweiger, K., Lurz, R., Lehrach, H. and Wanker, E.E.
Philosophical Transactions of the Royal Society of London Series B Biological Sciences 354
: 991-994.
29 June 1999
MAPKAP kinase 2 phosphorylates serum response factor in vitro and in vivo.
Heidenreich, O., Neininger, A., Schratt, G., Zinck, R., Cahill, M.A., Engel, K., Kotlyarov, A., Kraft, R., Kostka, S., Gaestel, M. and Nordheim, A.
Journal of Biological Chemistry 274
: 14434-14443.
14 May 1999
Formation of polyglutamine inclusions in non-CNS tissue.
Sathasivam, K., Hobbs, C., Turmaine, M., Mangiarini, L., Mahal, A., Bertaux, F., Wanker, E.E., Doherty, P., Davies, S.W. and Bates, G.P.
Human Molecular Genetics 8
: 813-822.
1 May 1999
Nucleoid proteins of pea chloroplasts: Detection of a protein homologous to ribosomal protein.
Oleskina, Y.P., Yurina, N.P., Odintsova, T.I., Egorov, T.A., Otto, A., Wittmann-Liebold, B. and Odintsova, M.S.
Biochemistry and Molecular Biology International 47
: 757-763.
1 May 1999
Sequence information within proteasomal prosequences mediates efficient integration of beta-subunits into the 20 S proteasome complex.
Schmidt, M., Zantopf, D., Kraft, R., Kostka, S., Preissner, R. and Kloetzel, P.M.
Journal of Molecular Biology 288
: 117-128.
23 April 1999
Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: implications for Huntington's disease pathology.
Scherzinger, E., Sittler, A., Schweiger, K., Heiser, V., Lurz, R., Hasenbank, R., Bates, G.P., Lehrach, H. and Wanker, E.E.
Proceedings of the National Academy of Sciences of the United States of America 96
(8): 4604-4609.
13 April 1999
Huntington's disease intranuclear inclusions contain truncated, ubiquitinated huntingtin protein.
Sieradzan, K.A., Mechan, A.O., Jones, L., Wanker, E.E., Nukina, N. and Mann, D.M.
Experimental Neurology 156
(1): 92-99.
1 March 1999
Cloning and characterization of a gene (mspA) encoding the major sheath protein Treponema maltophilum ATCC51939(T).
Heuner, K., Choi, B.K., Schade, R., Moter, A., Otto, A. and Goebel, U.B.
Journal of Bacteriology 181
: 1025-1029.
1 February 1999
Laccase of Coriolus zonatus - Isolation, purification, and some physicochemical properties.
Koroljova, O.V., Stepanova, E.V., Gavrilova, V.P., Biniukov, V.I., Jaropolov, A.I., Varfolomeyev, S.D., Scheller, F.W., Makower, A. and Otto, A.
Applied Biochemistry and Biotechnology 76
: 115-127.
1 February 1999
Study of Burkitt lymphoma cell line proteins by high resolution two-dimensional gel electrophoresis and nanoelectrospray mass spectrometry.
Mueller, E.C., Schuemann, M., Rickers, A., Bommert, K., Wittmann-Liebold, B. and Otto, A.
Electrophoresis 20
: 320-330.
1 February 1999
Preparative high-resolution two-dimensional electrophoresis enables the identification of RNA polymerase B transcription factor 3 as an apoptosis-associated protein in the human BL60-2 Burkitt lymphoma cell line.
Brockstedt, E., Otto, A., Rickers, A., Bommert, K. and Wittmann-Liebold, B.
Journal of Protein Chemistry 18
(2): 225-231.
February 1999
ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28.
Hutloff, A., Dittrich, A.M., Beier, K.C., Eljaschewitsch, B., Kraft, R., Anagnostopoulos, I. and Kroczek, R.A.
Nature 397
(6716): 263-266.
21 January 1999
Detection of polyglutamine aggregation in mouse models.
Davies, S.W., Sathasivam, K., Hobbs, C., Doherty, P., Mangiarini, L., Scherzinger, E., Wanker, E.E. and Bates, G.P.
Methods in Enzymology 309
: 687-701.
1 January 1999
Membrane filter assay for detection of amyloid-like polyglutamine-containing protein aggregates.
Wanker, E.E., Scherzinger, E., Heiser, V., Sittler, A., Eickhoff, H. and Lehrach, H.
Methods in Enzymology 309
: 375-386.
1 January 1999
1998
Characterization of the mouse Src homology 3 domain gene Sh3d2c on Chr 7 demonstrates coexpression with huntingtin in the brain and identifies the processed pseudogene Sh3d2c-ps1 on Chr 2.
Zechner, U., Scheel, S., Hemberger, M., Hopp, M., Haaf, T., Fundele, R., Wanker, E.E., Lehrach, H., Wedemeyer, N. and Himmelbauer, H.
Genomics 54
: 505-510.
15 December 1998
Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line - cleavage of heterogeneous nuclear ribonucleoprotein A1 by caspase 3.
Brockstedt, E., Rickers, A., Kostka, S., Laubersheimer, A., Doerken, B., Wittmann-Liebold, B., Bommert, K. and Otto, A.
Journal of Biological Chemistry 273
(43): 28057-28064.
23 October 1998
SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates.
Sittler, A., Walter, S., Wedemeyer, N., Hasenbank, R., Scherzinger, E., Eickhoff, H., Bates, G.P., Lehrach, H. and Wanker, E.E.
Molecular Cell 2
(4): 427-436.
October 1998
Identification of mouse crystallins in 2D protein patterns by sequencing and mass spectrometry. Application to cataract mutants.
Jungblut, P.R., Otto, A., Favor, J., Loewe, M., Mueller, E.C., Kastner, M., Sperling, K. and Klose, J.
FEBS Letters 435
: 131-137.
18 September 1998
Precise determination of RNA-protein contact sites in the 50 S ribosomal subunit of Escherichia coli.
Thiede, B., Urlaub, H., Neubauer, H., Grelle, G. and Wittmann-Liebold, B.
Biochemical Journal 334 P.1
: 39-42.
15 August 1998
High performance two dimensional gel electrophoresis and nanoelectrospray mass spectrometry as powerful tool to study apoptosis-associated processes in a Burkitt lymphoma cell line.
Otto, A., Mueller, E.C., Brockstedt, E., Schumann, M., Rickers, A., Bommert, K. and Wittmann-Liebold, B.
Journal of Protein Chemistry 17
: 564-565.
1 August 1998
Polyglutamine expansion and Huntington's disease.
Bates, G.P., Mangiarini, L., Wanker, E.E. and Davies, S.W.
Biochemical Society Transactions 26
: 471-475.
1 August 1998
The monoclonal antibody AS02 recognizes a protein on human fibroblasts being highly homologous to Thy-1.
Saalbach, A., Kraft, R., Herrmann, K., Haustein, U.F. and Anderegg, U.
Archives of Dermatological Research 290
: 360-366.
1 July 1998
Ataxin-3 is transported into the nucleus and associates with the nuclear matrix.
Tait, D., Riccio, M., Sittler, A., Scherzinger, E., Santi, S., Ognibene, A., Maraldi, N.M., Lehrach, H. and Wanker, E.E.
Human Molecular Genetics 7
(6): 991-997.
June 1998
Huntingtin aggregation monitored by dynamic light scattering.
Georgalis, Y., Starikov, E.B., Hollenbach, B., Lurz, R., Scherzinger, E., Saenger, W., Lehrach, H. and Wanker, E.E.
Proceedings of the National Academy of Sciences of the United States of America 95
(11): 6118-6121.
26 May 1998
HAP1-huntingtin interactions do not contribute to the molecular pathology in Huntington's disease transgenic mice.
Bertaux, F., Sharp, A.H., Ross, C.A., Lehrach, H., Bates, G.P. and Wanker, E.E.
FEBS Letters 426
: 229-232.
17 April 1998
A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits.
Seeger, M., Kraft, R., Ferrell, K., Bech-Otschir, D., Dumedey, R., Schade, R., Gordon, C., Naumann, M. and Dubiel, W.
FASEB Journal 12
(6): 469-478.
1 April 1998
Acid nuclear extracts as mediators of gene transfer and expression.
Boettger, M., Zaitsev, S.V., Otto, A., Haberland, A. and Vorob'ev, V.I.
Biochimica et Biophysica Acta 1395
: 78-87.
1 January 1998
Hexokinase 2 from Saccharomyces cerevisiae: regulation of oligomeric structure by in vivo phosphorylation at serine-14.
Behlke, J., Heidrich, K., Naumann, M., Mueller, E.C., Otto, A., Reuter, R. and Kriegel, T.
Biochemistry 37
: 11989-11995.
1 January 1998
IRS-PCR-based genetic mapping of the huntingtin interacting protein gene (HIP1) on mouse chromosome 5.
Himmelbauer, H., Wedemeyer, N., Haaf, T., Wanker, E.E., Schalkwyk, L.C. and Lehrach, H.
Mammalian Genome 9
: 26-31.
1 January 1998
Inhibition of CPP32 blocks surface IgM-mediated apoptosis and D4-GDI cleavage in human BL 60 Burkitt lymphoma cells.
Rickers, A., Brockstedt, E., Mapara, M.Y., Otto, A., Doerken, B. and Bommert, K.
European Journal of Immunology 28
: 296-304.
1 January 1998
Mammalian protein homologous to VAT-1 of torpedo californica: isolation from Ehrlich Ascites Tumor cells, biochemical characterization and organization of its gene.
Hayess, K., Kraft, R., Sachsinger, J., Janke, J., Jandrig, B., Beckmann, G., Rohde, K. and Benndorf, R.
Journal of Cellular Biochemistry 69
: 304-315.
1 January 1998
1997
Localization of the human HIP1 gene close to the elastin (ELN) locus on 7q11.23.
Wedemeyer, N., Peoples, R., Himmelbauer, H., Lehrach, H., Francke, U. and Wanker, E.E.
Genomics 46
: 313-315.
1 December 1997
Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation.
Davies, S.W., Turmaine, M., Cozens, B.A., DiFiglia, M., Sharp, A.H., Ross, C.A., Scherzinger, E., Wanker, E.E., Mangiarini, L. and Bates, G.P.
Cell 90
(3): 537-548.
8 August 1997
Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo.
Scherzinger, E., Lurz, R., Turmaine, M., Mangiarini, L., Hollenbach, B., Hasenbank, R., Bates, G.P., Davies, S.W., Lehrach, H. and Wanker, E.E.
Cell 90
(3): 549-558.
8 August 1997
HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system.
Wanker, E.E., Rovira, C., Scherzinger, E., Hasenbank, R., Walter, S., Tait, D., Colicelli, J. and Lehrach, H.
Human Molecular Genetics 6
(3): 487-495.
1 March 1997
Chicken acidic leucine-rich EGF-like domain containing brain protein (CALEB), a neural member of the EGF family of differentiation factors, is implicated in neurite formation.
Schumacher, S., Volkmer, H., Buck, F., Otto, A., Tarnok, A., Roth, S. and Rathjen, F.G.
Journal of Cell Biology 136
(4): 895-906.
24 February 1997
Export of importin alpha from the nucleus is mediated by a specific nuclear transport factor.
Kutay, U., Bischoff, F.R., Kostka, S., Kraft, R. and Goerlich, D.
Cell 90
: 1061-1071.
1 January 1997
Identification and characterization of heat shock protein 27 protein species in human myocardial two-dimensional electrophoresis patterns.
Scheler, C., Mueller, E.C., Stahl, J., Mueller-Werdan, U., Salnikov, J. and Jungblut, P.
Electrophoresis 18
: 2823-2831.
1 January 1997
Purification, structural analysis, and function of natural atac, a cytokine secreted by cd8(+) T cells.
Dorner, B., Mueller, S., Entschladen, F., Schroeder, J.M., Frankel, P., Kraft, R., Friedl, P., Clarklewis, I. and Kroczek, R.A.
Journal of Biological Chemistry 272
: 8817-8823.
1 January 1997
1995
Efficient secretion of Bacillus subtilis levanase by Saccharomyces cerevisiae.
Wanker, E.E., Klingsbichel, E. and Schwab, H.
Gene 161
: 45-49.
8 August 1995
Functional characterization of the 180-kD ribosome receptor in vivo.
Wanker, E.E., Sun, Y., Savitz, A.J. and Meyer, D.I.
Journal of Cell Biology 130
(1): 29-39.
July 1995
Expression of Bacillus subtilis levanase gene in Lactobacillus plantarum and Lactobacillus casei.
Wanker, E.E., Leer, R.J., Pouwels, P.H. and Schwab, H.
Applied Microbiology and Biotechnology 43
: 297-303.
1 May 1995
Purification and characterization of the Bacillus subtilis levanase produced in Escherichia coli.
Wanker, E.E., Huber, A. and Schwab, H.
Applied and Environmental Microbiology 61
: 1953-1958.
1 May 1995
1991
Expression of the Bacillus subtilis levanase gene in Escherichia coli and Saccharomyces cerevisiae.
Wanker, E.E., Schorgendorfer, K. and Schwab, H.
Journal of Biotechnology 18
: 243-254.
1 May 1991
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