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Mitochondria and the dynamic control of stem cell homeostasis

Item Type:Review
Title:Mitochondria and the dynamic control of stem cell homeostasis
Creators Name:Lisowski, P., Kannan, P., Mlody, B. and Prigione, A.
Abstract:The maintenance of cellular identity requires continuous adaptation to environmental changes. This process is particularly critical for stem cells, which need to preserve their differentiation potential over time. Among the mechanisms responsible for regulating cellular homeostatic responses, mitochondria are emerging as key players. Given their dynamic and multifaceted role in energy metabolism, redox, and calcium balance, as well as cell death, mitochondria appear at the interface between environmental cues and the control of epigenetic identity. In this review, we describe how mitochondria have been implicated in the processes of acquisition and loss of stemness, with a specific focus on pluripotency. Dissecting the biological functions of mitochondria in stem cell homeostasis and differentiation will provide essential knowledge to understand the dynamics of cell fate modulation, and to establish improved stem cell-based medical applications.
Keywords:Differentiation, Metabolism, Mitochondria, Pluripotency, PSCs, Animals
Source:EMBO Reports
Publisher:EMBO Press / Wiley
Page Range:e45432
Date:1 May 2018
Official Publication:https://doi.org/10.15252/embr.201745432
External Fulltext:View full text on PubMed Central
PubMed:View item in PubMed

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