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The IgCAM BT-IgSF (IgSF11) is essential for connexin43-mediated astrocyte-astrocyte coupling in mice.
Pelz, L. and Dossou, L. and Kompier, N. and Jüttner, R. and Siemonsmeier, G. and Meyer, N. and Lowenstein, E.D. and Lahmann, I. and Kettenmann, H. and Birchmeier, C. and Rathjen, F.G.
eNeuro
22 February 2024
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Prox2 and Runx3 vagal sensory neurons regulate esophageal motility.
Lowenstein, E.D. and Ruffault, P.L. and Misios, A. and Osman, K.L. and Li, H. and Greenberg, R.S. and Thompson, R. and Song, K. and Dietrich, S. and Li, X. and Vladimirov, N. and Woehler, A. and Brunet, J.F. and Zampieri, N. and Kühn, R. and Liberles, S.D. and Jia, S. and Lewin, G.R. and Rajewsky, N. and Lever, T.E. and Birchmeier, C.
Neuron 111
(14): 2184-2200.e7.
19 July 2023
c-Maf-positive spinal cord neurons are critical elements of a dorsal horn circuit for mechanical hypersensitivity in neuropathy.
Frezel, N. and Ranucci, M. and Foster, E. and Wende, H. and Pelczar, P. and Mendes, R. and Ganley, R.P. and Werynska, K. and d'Aquin, S. and Beccarini, C. and Birchmeier, C. and Zeilhofer, H.U. and Wildner, H.
Cell Reports 42
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21 March 2023
Molecular characterization of the intact mouse muscle spindle using a multi-omics approach.
Bornstein, B. and Heinemann-Yerushalmi, L. and Krief, S. and Adler, R. and Dassa, B. and Leshkowitz, D. and Kim, M.C. and Bewick, G. and Banks, R.W. and Zelzer, E.
eLife 12
: e81843.
6 February 2023
Visualizing MyoD oscillations in muscle stem cells.
Lahmann, I. and Birchmeier, C.
Methods in Molecular Biology 2640
: 259-276.
2023
Molecular identity of proprioceptor subtypes innervating different muscle groups in mice.
Dietrich, S. and Company, C. and Song, K. and Lowenstein, E.D. and Riedel, L. and Birchmeier, C. and Gargiulo, G. and Zampieri, N.
Nature Communications 13
(1): 6867.
11 November 2022
Mafa-dependent GABAergic activity promotes mouse neonatal apneas.
Lecoin, L. and Dempsey, B. and Garancher, A. and Bourane, S. and Ruffault, P.L. and Morin-Surun, M.P. and Rocques, N. and Goulding, M. and Eychène, A. and Pouponnot, C. and Fortin, G. and Champagnat, J.
Nature Communications 13
(1): 3284.
7 June 2022
SMER28 attenuates PI3K/mTOR signaling by direct inhibition of PI3K p110 delta.
Kirchenwitz, M. and Stahnke, S. and Prettin, S. and Borowiak, M. and Menke, L. and Sieben, C. and Birchmeier, C. and Rottner, K. and Stradal, T.E.B. and Steffen, A.
Cells 11
(10): 1648.
16 May 2022
A medullary centre for lapping in mice.
Dempsey, B. and Sungeelee, S. and Bokiniec, P. and Chettouh, Z. and Diem, S. and Autran, S. and Harrell, E.R. and Poulet, J.F.A. and Birchmeier, C. and Carey, H. and Genovesio, A. and McMullan, S. and Goridis, C. and Fortin, G. and Brunet, J.F.
Nature Communications 12
: 6307.
2 November 2021
Technologies for profiling the impact of genomic variants on transcription factor binding.
Leiz, J. and Rutkiewicz, M. and Birchmeier, C. and Heinemann, U. and Schmidt-Ott, K.M.
Medizinische Genetik 33
(2): 147-155.
14 August 2021
Met and Cxcr4 cooperate to protect skeletal muscle stem cells against inflammation-induced damage during regeneration.
Lahmann, I. and Griger, J. and Chen, J.S. and Zhang, Y. and Schülke, M. and Birchmeier-Kohler, C.
eLife 10
: e57356.
5 August 2021
Oscillations of Delta-like1 regulate the balance between differentiation and maintenance of muscle stem cells.
Zhang, Y. and Lahmann, I. and Baum, K. and Shimojo, H. and Mourikis, P. and Wolf, J. and Kageyama, R. and Birchmeier, C.
Nature Communications 12
(1): 1318.
26 February 2021
Olig3 regulates early cerebellar development.
Lowenstein, E.D. and Rusanova, A. and Stelzer, J. and Hernaiz-Llorens, M. and Schroer, A.E. and Epifanova, E. and Bladt, F. and Isik, E.G. and Buchert, S. and Jia, S. and Tarabykin, V. and Hernandez-Miranda, L.R.
eLife 10
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16 February 2021
Sepsis induces interleukin 6, gp130/JAK2/STAT3, and muscle wasting.
Zanders, L. and Kny, M. and Hahn, A. and Schmidt, S. and Wundersitz, S. and Todiras, M. and Lahmann, I. and Bandyopadhyay, A. and Wollersheim, T. and Kaderali, L. and Luft, F.C. and Birchmeier, C. and Weber-Carstens, S. and Fielitz, J.
Journal of Cachexia Sarcopenia and Muscle 13
(1): 713-727.
February 2021
Single-nucleus transcriptomics reveals functional compartmentalization in syncytial skeletal muscle cells.
Kim, M. and Franke, V. and Brandt, B. and Lowenstein, E.D. and Schöwel, V. and Spuler, S. and Akalin, A. and Birchmeier, C.
Nature Communications 11
: 6375.
11 December 2020
SIX1 and SIX4 homeoproteins regulate PAX7+ progenitor cell properties during fetal epaxial myogenesis.
Wurmser, M. and Chaverot, N. and Madani, R. and Sakai, H. and Negroni, E. and Demignon, J. and Saint-Pierre, B. and Mouly, V. and Amthor, H. and Tapscott, S. and Birchmeier, C. and Tajbakhsh, S. and Le Grand, F. and Sotiropoulos, A. and Maire, P.
Development 147
(19): dev185975.
9 October 2020
EHD2-mediated restriction of caveolar dynamics regulates cellular fatty acid uptake.
Matthaeus, C. and Lahmann, I. and Kunz, S. and Jonas, W. and Melo, A.A. and Lehmann, M. and Larsson, E. and Lundmark, R. and Kern, M. and Blüher, M. and Olschowski, H. and Kompa, J. and Brügger, B. and Müller, D.N. and Haucke, V. and Schürmann, A. and Birchmeier, C. and Daumke, O.
Proceedings of the National Academy of Sciences of the United States of America 117
(13): 7471-7481.
31 March 2020
Self-organizing 3D human trunk neuromuscular organoids.
Faustino Martins, J.M. and Fischer, C. and Urzi, A. and Vidal, R. and Kunz, S. and Ruffault, P.L. and Kabuss, L. and Hube, I. and Gazzerro, E. and Birchmeier, C. and Spuler, S. and Sauer, S. and Gouti, M.
Cell Stem Cell 26
(2): 172-186.
6 February 2020
Human muscle-derived CLEC14A-positive cells regenerate muscle independent of PAX7.
Marg, A. and Escobar Fernandez, H. and Karaiskos, N. and Grunwald, S.A. and Metzler, E. and Kieshauer, J. and Sauer, S. and Pasemann, D. and Malfatti, E. and Mompoint, D. and Quijano-Roy, S. and Boltengagen, A. and Schneider, J. and Schülke, M. and Kunz, S. and Carlier, R. and Birchmeier, C. and Amthor, H. and Spuler, A. and Kocks, C. and Rajewsky, N. and Spuler, S.
Nature Communications 10
(1): 5776.
18 December 2019
Context-specific regulation of cell survival by a miRNA-controlled BIM rheostat.
Labi, V. and Peng, S. and Klironomos, F. and Munschauer, M. and Kastelic, N. and Chakraborty, T. and Schoeler, K. and Derudder, E. and Martella, M. and Mastrobuoni, G. and Hernandez-Miranda, L.R. and Lahmann, I. and Kocks, C. and Birchmeier, C. and Kempa, S. and Quintanilla-Martinez de Fend, L. and Landthaler, M. and Rajewsky, N. and Rajewsky, K.
Genes & Development 33
: 23-24.
7 November 2019
β-secretase BACE1 is required for normal cochlear function.
Dierich, M. and Hartmann, S. and Dietrich, N. and Moeser, P. and Brede, F. and Johnson Chacko, L. and Tziridis, K. and Schilling, A. and Krauss, P. and Hessler, S. and Karch, S. and Schrott-Fischer, A. and Blumer, M. and Birchmeier, C. and Oliver, D. and Moser, T. and Schulze, H. and Alzheimer, C. and Leitner, M.G. and Huth, T.
Journal of Neuroscience 39
(45): 9013-9027.
6 November 2019
eNOS-NO-induced small blood vessel relaxation requires EHD2-dependent caveolae stabilization.
Matthaeus, C. and Lian, X. and Kunz, S. and Lehmann, M. and Zhong, C. and Bernert, C. and Lahmann, I. and Müller, D.N. and Gollasch, M. and Daumke, O.
PLoS ONE 14
(10): e0223620.
10 October 2019
Ribosome profiling of selenoproteins in vivo reveals consequences of pathogenic Secisbp2 missense mutations.
Zhao, W. and Bohleber, S. and Schmidt, H. and Seeher, S. and Howard, M.T. and Braun, D. and Arndt, S. and Reuter, U. and Wende, H. and Birchmeier, C. and Fradejas-Villar, N. and Schweizer, U.
Journal of Biological Chemistry 294
(39): 14185-14200.
27 September 2019
Teashirt 1 (Tshz1) is essential for the development, survival and function of hypoglossal and phrenic motor neurons in mouse.
Chaimowicz, C. and Ruffault, P.L. and Chéret, C. and Woehler, A. and Zampieri, N. and Fortin, G. and Garratt, A.N. and Birchmeier, C.
Development 146
(17): dev174045.
6 September 2019
Oscillations of MyoD and Hes1 proteins regulate the maintenance of activated muscle stem cells.
Lahmann, I. and Bröhl, D. and Zyrianova, T. and Isomura, A. and Czajkowski, M.T. and Kapoor, V. and Griger, J. and Ruffault, P.L. and Mademtzoglou, D. and Zammit, P.S. and Wunderlich, T. and Spuler, S. and Kühn, R. and Preibisch, S. and Wolf, J. and Kageyama, R. and Birchmeier, C.
Genes & Development 33
(9-10): 524-535.
1 May 2019
HDAC4 mutations cause diabetes and induce β-cell FoxO1 nuclear exclusion.
Gong, M. and Yu, Y. and Liang, L. and Vuralli, D. and Froehler, S. and Kuehnen, P. and Du Bois, P. and Zhang, J. and Cao, A. and Liu, Y. and Hussain, K. and Fielitz, J. and Jia, S. and Chen, W. and Raile, K.
Molecular Genetics & Genomic Medicine 7
(5): e602.
May 2019
Alternative 3' UTRs direct localization of functionally diverse protein isoforms in neuronal compartments.
Ciolli Mattioli, C. and Rom, A. and Franke, V. and Imami, K. and Arrey, G. and Terne, M. and Woehler, A. and Akalin, A. and Ulitsky, I. and Chekulaeva, M.
Nucleic Acids Research 47
(5): 2560-2573.
18 March 2019
240th ENMC workshop: The involvement of skeletal muscle stem cells in the pathology of muscular dystrophies 25–27 January 2019, Hoofddorp, The Netherlands.
Morgan, J. and Butler-Browne, G. and Muntoni, F. and Patel, K.
Neuromuscular Disorders 29
(9): 704-715.
2019
Mutation in LBX1/Lbx1 precludes transcription factor cooperativity and causes congenital hypoventilation in humans and mice.
Hernandez-Miranda, L.R. and Ibrahim, D.M. and Ruffault, P.L. and Larrosa, M. and Balueva, K. and Müller, T. and de Weerd, W. and Stolte-Dijkstra, I. and Hostra, R.M.W. and Brunet, J.F. and Fortin, G. and Mundlos, S. and Birchmeier, C.
Proceedings of the National Academy of Sciences of the United States of America 115
(51): 13021-13026.
18 December 2018
Haploinsufficiency of Insm1 impairs postnatal baseline β-cell mass.
Tao, W. and Zhang, Y. and Ma, L. and Deng, C. and Duan, H. and Liang, X. and Liao, R. and Lin, S. and Nie, T. and Chen, W. and Wang, C. and Birchmeier, C. and Jia, S.
Diabetes 67
(12): 2615-2625.
December 2018
Mutations in disordered regions can cause disease by creating dileucine motifs.
Meyer, K. and Kirchner, M. and Uyar, B. and Cheng, J.Y. and Russo, G. and Hernandez-Miranda, L.R. and Szymborska, A. and Zauber, H. and Rudolph, I.M. and Willnow, T.E. and Akalin, A. and Haucke, V. and Gerhardt, H. and Birchmeier, C. and Kühn, R. and Krauss, M. and Diecke, S. and Pascual, J.M. and Selbach, M.
Cell 175
(1): 239-253.
20 September 2018
Neuregulin 3 promotes excitatory synapse formation on hippocampal interneurons.
Müller, T. and Braud, S. and Jüttner, R. and Voigt, B.C. and Paulick, K. and Sheean, M.E. and Klisch, C. and Gueneykaya, D. and Rathjen, F.G. and Geiger, J.R.P. and Poulet, J.F.A. and Birchmeier, C.
EMBO Journal 37
(17): e98858.
3 September 2018
Maf links Neuregulin1 signaling to cholesterol synthesis in myelinating Schwann cells.
Kim, M. and Wende, H. and Walcher, J. and Kühnemund, J. and Cheret, C. and Kempa, S. and McShane, E. and Selbach, M. and Lewin, G.R. and Birchmeier, C.
Genes & Development 32
(9-10): 645-657.
10 May 2018
Predominant patterns of splicing evolution on human, chimpanzee, and macaque evolutionary lineages.
Xiong, J. and Xi, J. and Ditsiou, A. and Gao, Y. and Sun, J. and Lowenstein, E.D. and Huang, S. and Khaitovich, P.
Human Molecular Genetics 27
(8): 1474-1485.
15 April 2018
Sustained MAPK/ERK activation in adult Schwann cells impairs nerve repair.
Cervellini, I. and Galino, J. and Zhu, N. and Allen, S. and Birchmeier, C. and Bennett, D.L.
Journal of Neuroscience 38
(3): 679-690.
17 January 2018
Dual origin of enteric neurons in vagal Schwann cell precursors and the sympathetic neural crest.
Espinosa-Medina, I. and Jevans, B. and Boismoreau, F. and Chettouh, Z. and Enomoto, H. and Müller, T. and Birchmeier, C. and Burns, Alan J and Brunet, J.F.
Proceedings of the National Academy of Sciences of the United States of America 114
(45): 11980-11985.
7 November 2017
Mutations in MYO1H cause a recessive form of central hypoventilation with autonomic dysfunction.
Spielmann, M. and Hernandez-Miranda, L.R. and Ceccherini, I. and Weese-Mayer, D.E. and Kragesteen, B.K. and Harabula, I. and Krawitz, P. and Birchmeier, C. and Leonard, N. and Mundlos, S.
Journal of Medical Genetics 54
(11): 754-761.
November 2017
Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function.
Piwecka, M. and Glažar, P. and Hernandez-Miranda, L.R. and Memczak, S. and Wolf, S.A. and Rybak-Wolf, A. and Filipchyk, A. and Klironomos, F. and Cerda Jara, C.A. and Fenske, P. and Trimbuch, T. and Zywitza, V. and Plass, M. and Schreyer, L. and Ayoub, S. and Kocks, C. and Kühn, R. and Rosenmund, C. and Birchmeier, C. and Rajewsky, N.
Science 357
(6357): eaam8526.
22 September 2017
RNA localization is a key determinant of neurite-enriched proteome.
Zappulo, A. and van den Bruck, D. and Ciolli Mattioli, C. and Franke, V. and Imami, K. and McShane, E. and Moreno-Estelles, M. and Calviello, L. and Filipchyk, A. and Peguero-Sanchez, E. and Müller, T. and Woehler, A. and Birchmeier, C. and Merino, E. and Rajewsky, N. and Ohler, U. and Mazzoni, E.O. and Selbach, M. and Akalin, A. and Chekulaeva, M.
Nature Communications 8
(1): 583.
19 September 2017
BMP signaling regulates satellite cell dependent postnatal muscle growth.
Stantzou, A. and Schirwis, E. and Swist, S. and Alonso-Martin, S. and Polydorou, I. and Zarrouki, F. and Mouisel, E. and Beley, C. and Julien, A. and Le Grand, F. and Garcia, L. and Colnot, C. and Birchmeier, C. and Braun, T. and Schuelke, M. and Relaix, F. and Amthor, H.
Development 144
(15): 2737-2747.
1 August 2017
Genetic identification of a hindbrain nucleus essential for innate vocalization.
Hernandez-Miranda, L.R. and Ruffault, P.L. and Bouvier, J.C. and Murray, A.J. and Morin-Surun, M.P. and Zampieri, N. and Cholewa-Waclaw, J.B. and Ey, E. and Brunet, J.F. and Champagnat, J. and Fortin, G. and Birchmeier, C.
Proceedings of the National Academy of Sciences of the United States of America 114
(30): 8095-8100.
25 July 2017
Cell fixation and preservation for droplet-based single-cell transcriptomics.
Alles, J. and Karaiskos, N. and Praktiknjo, S.D. and Grosswendt, S. and Wahle, P. and Ruffault, P.L. and Ayoub, S. and Schreyer, L. and Boltengagen, A. and Birchmeier, C. and Zinzen, R. and Kocks, C. and Rajewsky, N.
BMC Biology 15
(1): 44.
19 May 2017
Loss of Ptpn11 (Shp2) drives satellite cells into quiescence.
Griger, J. and Schneider, R. and Lahmann, I. and Schöwel, V. and Keller, C. and Spuler, S. and Nazare, M. and Birchmeier, C.
eLife 6
: e21552.
2 May 2017
Homozygous ARHGEF2 mutation causes intellectual disability and midbrain-hindbrain malformation.
Ravindran, E. and Hu, H. and Yuzwa, S.A. and Hernandez-Miranda, L.R. and Kraemer, N. and Ninnemann, O. and Musante, L. and Boltshauser, E. and Schindler, D. and Hübner, A. and Reinecker, H.-C. and Ropers, H.-H. and Birchmeier, C. and Miller, F.D. and Wienker, T.F. and Hübner, C. and Kaindl, A.M.
PLoS Genetics 13
(4): e1006746.
28 April 2017
Neuregulin-1 mutant mice indicate motor and sensory deficits, indeed few references for schizophrenia endophenotype model.
Schneider, S. and Götz, K. and Birchmeier, C. and Schwegler, H. and Roskoden, T.
Behavioural Brain Research 322
(Pt A): 177-185.
30 March 2017
Touch receptor-derived sensory information alleviates acute pain signaling and fine-tunes nociceptive reflex coordination.
Arcourt, A. and Gorham, L. and Dhandapani, R. and Prato, V. and Taberner, F.J. and Wende, H. and Gangadharan, V. and Birchmeier, C. and Heppenstall, P.A. and Lechner, S.G.
Neuron 93
(1): 179-193.
4 January 2017
Muscle contraction is required to maintain the pool of muscle progenitors via YAP and NOTCH during fetal myogenesis.
Esteves de Lima, J. and Bonnin, M.A. and Birchmeier, C. and Duprez, D.
eLife 5
: e15593.
24 August 2016
Neuregulin-1 controls an endogenous repair mechanism after spinal cord injury.
Bartus, K. and Galino, J. and James, N.D. and Hernandez-Miranda, L.R. and Dawes, J.M. and Fricker, F.R. and Garratt, A.N. and McMahon, S.B. and Ramer, M.S. and Birchmeier, C. and Bennett, D.L.H. and Bradbury, E.J.
Brain 139
(Pt 5): 1394-1416.
May 2016
Insm1 controls the differentiation of pulmonary neuroendocrine cells by repressing Hes1.
Jia, S. and Wildner, H. and Birchmeier, C.
Developmental Biology 408
(1): 90-98.
1 December 2015
Bcl11a (Ctip1) controls migration of cortical projection neurons through regulation of Sema3c.
Wiegreffe, C. and Simon, R. and Peschkes, K. and Kling, C. and Strehle, M. and Cheng, J. and Srivatsa, S. and Liu, P. and Jenkins, N.A. and Copeland, N.G. and Tarabykin, V. and Britsch, S.
Neuron 87
(2): 311-325.
15 July 2015
Insm1 cooperates with Neurod1 and Foxa2 to maintain mature pancreatic β-cell function.
Jia, S. and Ivanov, A. and Blasevic, D. and Müller, T. and Purfürst, B. and Sun, W. and Chen, W. and Poy, M.N. and Rajewsky, N. and Birchmeier, C.
EMBO Journal 34
(10): 1417-1433.
12 May 2015
Quantitative proteomics reveals dynamic interaction of c-Jun N-terminal kinase (JNK) with RNA transport granule proteins splicing factor proline- and glutamine-rich (Sfpq) and non-POU domain-containing octamer-binding protein (Nono) during neuronal differentiation.
Sury, M.D. and McShane, E. and Hernandez-Miranda, L.R. and Birchmeier, C. and Selbach, M.
Molecular & Cellular Proteomics 14
(1): 50-65.
1 January 2015
Divergent and conserved roles of Dll1 signaling in development of craniofacial and trunk muscle.
Czajkowski, M.T. and Rassek, C. and Lenhard, D. and Bröhl, D. and Birchmeier, C.
Developmental Biology 395
(2): 307-3016.
15 November 2014
Neuregulin-3 in the mouse medial prefrontal cortex regulates impulsive action.
Loos, M. and Mueller, T. and Gouwenberg, Y. and Wijnands, R. and van der Loo, R.J. and Birchmeier, C. and Smit, A.B. and Spijker, S.
Biological Psychiatry 76
(8): 648-655.
15 October 2014
Human satellite cells have regenerative capacity and are genetically manipulable.
Marg, A. and Escobar, H. and Gloy, S. and Kufeld, M. and Zacher, J. and Spuler, A. and Birchmeier, C. and Izsvák, Z. and Spuler, S.
Journal of Clinical Investigation 124
(10): 4257-4265.
1 October 2014
Recessive mutations in PCBD1 cause a new type of early-onset diabetes.
Simaite, D. and Kofent, J. and Gong, M. and Rüschendorf, F. and Jia, S. and Arn, P. and Bentler, K. and Ellaway, C. and Kühnen, P. and Hoffmann, G.F. and Blau, N. and Spagnoli, F.M. and Hübner, N. and Raile, K.
Diabetes 63
(10): 3557-3564.
October 2014
Parasympathetic neurons originate from nerve-associated peripheral glial progenitors.
Dyachuk, V. and Furlan, A. and Shahidi, M.K. and Giovenco, M. and Kaukua, N. and Konstantinidou, C. and Pachnis, V. and Memic, F. and Marklund, U. and Müller, T. and Birchmeier, C. and Fried, K. and Ernfors, P. and Adameyko, I.
Science 345
(6192): 82-87.
4 July 2014
Antagonistic regulation of p57(kip2) by Hes/Hey downstream of Notch signaling and muscle regulatory factors regulates skeletal muscle growth arrest.
Zalc, A. and Hayashi, S. and Auradé, F. and Bröhl, D. and Chang, T. and Mademtzoglou, D. and Mourikis, P. and Yao, Z. and Cao, Y. and Birchmeier, C. and Relaix, F.
Development 141
(14): 2780-2790.
July 2014
TSHZ1-dependent gene regulation is essential for olfactory bulb development and olfaction.
Ragancokova, D. and Rocca, E. and Oonk, A.M.M. and Schulz, H. and Rohde, E. and Bednarsch, J. and Feenstra, I. and Pennings, R.J.E. and Wende, H. and Garratt, A.N.
Journal of Clinical Investigation 124
(3): 1214-1227.
3 March 2014
Activation of MAPK overrides the termination of myelin growth and replaces Nrg1/ErbB3 signals during Schwann cell development and myelination.
Sheean, M.E. and McShane, E. and Cheret, C. and Walcher, J. and Müller, T. and Wulf-Goldenberg, A. and Hoelper, S. and Garratt, A.N. and Krüger, M. and Rajewsky, K. and Meijer, D. and Birchmeier, W. and Lewin, G.R. and Selbach, M. and Birchmeier, C.
Genes & Development 28
(3): 290-303.
1 February 2014
Insm1 controls development of pituitary endocrine cells and requires a SNAG domain for function and for recruitment of histone-modifying factors.
Welcker, J.E. and Hernandez-Miranda, L.R. and Paul, F.E. and Jia, S. and Ivanov, A. and Selbach, M. and Birchmeier, C.
Development 140
(24): 4947-4958.
December 2013
Wnt/Rspondin/β-catenin signals control axonal sorting and lineage progression in Schwann cell development.
Grigoryan, T. and Stein, S. and Qi, J. and Wende, H. and Garratt, A.N. and Nave, K.A. and Birchmeier, C. and Birchmeier, W.
Proceedings of the National Academy of Sciences of the United States of America 110
(45): 18174-18179.
5 November 2013
BMP signaling controls muscle mass.
Sartori, R. and Schirwis, E. and Blaauw, B. and Bortolanza, S. and Zhao, J. and Enzo, E. and Stantzou, A. and Mouisel, E. and Toniolo, L. and Ferry, A. and Stricker, S. and Goldberg, A.L. and Dupont, S. and Piccolo, S. and Amthor, H. and Sandri, M.
Nature Genetics 45
(11): 1309-1318.
November 2013
Ontogeny of excitatory spinal neurons processing distinct somatic sensory modalities.
Xu, Y. and Lopes, C. and Wende, H. and Guo, Z. and Cheng, L. and Birchmeier, C. and Ma, Q.
Journal of Neuroscience 33
(37): 14738-14748.
11 September 2013
Inactivation of ceramide synthase 6 in mice results in an altered sphingolipid metabolism and behavioral abnormalities.
Ebel, P. and Vom Dorp, K. and Petrasch-Parwez, E. and Zlomuzica, A. and Kinugawa, K. and Mariani, J. and Minich, D. and Ginkel, C. and Welcker, J. and Degen, J. and Eckhardt, M. and Dere, E. and Doermann, P. and Willecke, K.
Journal of Biological Chemistry 288
(29): 21433-21447.
19 July 2013
Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles.
Cheret, C. and Willem, M. and Fricker, F.R. and Wende, H. and Wulf-Goldenberg, A. and Tahirovic, S. and Nave, K.A. and Saftig, P. and Haass, C. and Garratt, A.N. and Bennett, D.L. and Birchmeier, C.
EMBO Journal 32
(14): 2015-2028.
17 July 2013
Axonal neuregulin 1 is a rate limiting but not essential factor for nerve remyelination.
Fricker, F.R. and Antunes-Martins, A. and Galino, J. and Paramsothy, R. and La Russa, F. and Perkins, J. and Goldberg, R. and Brelstaff, J. and Zhu, N. and McMahon, S.B. and Orengo, C. and Garratt, A.N. and Birchmeier, C. and Bennett, D.L.
Brain 136
(Pt 7): 2279-2297.
July 2013
Genome-wide expression analysis of ptf1a- and ascl1-deficient mice reveals new markers for distinct dorsal horn interneuron populations contributing to nociceptive reflex plasticity.
Wildner, H. and Das Gupta, R. and Bröhl, D. and Heppenstall, P.A. and Zeilhofer, H.U. and Birchmeier, C.
Journal of Neuroscience 33
(17): 7299-7307.
24 April 2013
Therapeutic potential of N-acetyl-glucagon-like peptide-1 in primary motor neuron cultures derived from non-transgenic and SOD1-G93A ALS mice.
Sun, H. and Knippenberg, S. and Thau, N. and Ragancokova, D. and Koerner, S. and Huang, D. and Dengler, R. and Doehler, K. and Petri, S.
Cellular and Molecular Neurobiology 33
(3): 347-357.
April 2013
The transcription factor c-Maf in sensory neuron development.
Wende, H. and Lechner, S.G. and Birchmeier, C.
Transcription 3
(6): 285-289.
November 2012
A validated regulatory network for Th17 cell specification.
Ciofani, M. and Madar, A. and Galan, C. and Sellars, M. and Mace, K. and Pauli, F. and Agarwal, A. and Huang, W. and Parkurst, C.N. and Muratet, M. and Newberry, K.M. and Meadows, S. and Greenfield, A. and Yang, Y. and Jain, P. and Kirigin, F.K. and Birchmeier, C. and Wagner, E.F. and Murphy, K.M. and Myers, R.M. and Bonneau, R. and Littman, D.R.
Cell 151
(2): 289-303.
12 October 2012
Colonization of the satellite cell niche by skeletal muscle progenitor cells depends on notch signals.
Broehl, D. and Vasyutina, E. and Czajkowski, M.T. and Griger, J. and Rassek, C. and Rahn, H.P. and Purfürst, B. and Wende, H. and Birchmeier, C.
Developmental Cell 23
(3): 469-481.
11 September 2012
The HGF receptor/Met tyrosine kinase is a key regulator of dendritic cell migration in skin immunity.
Baek, J.H. and Birchmeier, C. and Zenke, M. and Hieronymus, T.
Journal of Immunology 189
(4): 1699-1707.
15 August 2012
Nuclear movement during myotube formation is microtubule and dynein dependent and is regulated by Cdc42, Par6 and Par3.
Cadot, B. and Gache, V. and Vasyutina, E. and Falcone, S. and Birchmeier, C. and Gomes, E.R.
EMBO Reports 13
(8): 741-749.
1 August 2012
Uncoupling of PI3K from ErbB3 impairs mammary gland development but does not impact on ErbB2-induced mammary tumorigenesis.
Lahlou, H. and Mueller, T. and Sanguin-Gendreau, V. and Birchmeier, C. and Muller, W.J.
Cancer Research 72
(12): 3080-3090.
15 June 2012
A dual function of Bcl11b/Ctip2 in hippocampal neurogenesis.
Simon, R. and Brylka, H. and Schwegler, H. and Venkataramanappa, S. and Andratschke, J. and Wiegreffe, C. and Liu, P. and Fuchs, E. and Jenkins, N.A. and Copeland, N.G. and Birchmeier, C. and Britsch, S.
EMBO Journal 31
(13): 2922-2936.
15 May 2012
Bcl11a is required for neuronal morphogenesis and sensory circuit formation in dorsal spinal cord development.
John, A. and Brylka, H. and Wiegreffe, C. and Simon, R. and Liu, P. and Juettner, R. and Crenshaw, E.B. and Luyten, F.P. and Jenkins, N.A. and Copeland, N.G. and Birchmeier, C. and Britsch, S.
Development 139
(10): 1831-1841.
15 May 2012
The transcription factor c-Maf controls touch receptor development and function.
Wende, H. and Lechner, S.G. and Cheret, C. and Bourane, S. and Kolanczyk, M.E. and Pattyn, A. and Reuter, K. and Munier, F.L. and Carroll, P. and Lewin, G.R. and Birchmeier, C.
Science 335
(6074): 1373-1376.
16 March 2012
BACE1 dependent neuregulin processing: review.
Fleck, D. and Garratt, A.N. and Haass, C. and Willem, M.
Current Alzheimer Research 9
(2): 178-183.
February 2012
Sox2 and Mitf cross-regulatory interactions consolidate progenitor and melanocyte lineages in the cranial neural crest.
Adameyko, I. and Lallemend, F. and Furlan, A. and Zinin, N. and Aranda, S. and Kitambi, S.S. and Blanchart, A. and Favaro, R. and Nicolis, S. and Luebke, M. and Mueller, T. and Birchmeier, C. and Suter, U. and Zaitoun, I. and Takahashi, Y. and Ernfors, P.
Development 139
(2): 397-410.
15 January 2012
Homeoprotein Phox2b commands a somatic-to-visceral switch in cranial sensory pathways.
D'Autreaux, F. and Coppola, E. and Hirsch, M.R. and Birchmeier, C. and Brunet, J.F.
Proceedings of the National Academy of Sciences of the United States of America 108
(50): 20018-20023.
13 December 2011
Neural crest cell lineage restricts skeletal muscle progenitor cell differentiation through Neuregulin1-ErbB3 signaling.
Van Ho, A.T. and Hayashi, S. and Broehl, D. and Aurade, F. and Rattenbach, R. and Relaix, F.
Developmental Cell 21
(2): 273-287.
16 August 2011
Axonally derived neuregulin-1 is required for remyelination and regeneration after nerve injury in adulthood.
Fricker, F.R. and Lago, N. and Balarajah, S. and Tsantoulas, C. and Tanna, S. and Zhu, N. and Fageiry, S.K. and Jenkins, M. and Garratt, A.N. and Birchmeier, C. and Bennett, D.L.
Journal of Neuroscience 31
(9): 3225-3233.
2 March 2011
Neuregulin 1 sustains the gene regulatory network in both trabecular and nontrabecular myocardium.
Lai, D. and Forrai, A. and Liu, X. and Wolstein, O. and Michalicek, J. and Ahmed, I. and Garratt, A.N. and Birchmeier, C. and Zhou, M. and Hartley, L. and Robb, L. and Feneley, M.P. and Fatkin, D. and Harvey, R.P.
Circulation Research 107
(6): 715-727.
17 September 2010
Defective respiratory rhythmogenesis and loss of central chemosensitivity in Phox2b mutants targeting retrotrapezoid nucleus neurons.
Dubreuil, V. and Thoby-Brisson, M. and Rallu, M. and Persson, K. and Pattyn, A. and Birchmeier, C. and Brunet, J.F. and Fortin, G. and Goridis, C.
Journal of Neuroscience 29
(47): 14836-14846.
25 November 2009
Schwann cell precursors from nerve innervation are a cellular origin of melanocytes in skin.
Adameyko, I. and Lallemend, F. and Aquino, J.B. and Pereira, J.A. and Topilko, P. and Mueller, T. and Fritz, N. and Beljajeva, A. and Mochii, M. and Liste, I. and Usoskin, D. and Suter, U. and Birchmeier, C. and Ernfors, P.
Cell 139
(2): 366-379.
16 October 2009
The tyrosine phosphatase Shp2 (PTPN11) directs neuregulin-1/ErbB signaling throughout schwann cell development.
Grossmann, K.S. and Wende, H. and Paul, F.E. and Cheret, C. and Garratt, A.N. and Zurborg, S. and Feinberg, K. and Besser, D. and Schulz, H. and Peles, E. and Selbach, M. and Birchmeier, W. and Birchmeier, C.
Proceedings of the National Academy of Sciences of the United States of America 106
(39): 16704-16709.
29 September 2009
Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling.
Trimbuch, T. and Beed, P. and Vogt, J. and Schuchmann, S. and Maier, N. and Kintscher, M. and Breustedt, J. and Schuelke, M. and Streu, N. and Kieselmann, O. and Brunk, I. and Laube, G. and Strauss, U. and Battefeld, A. and Wende, H. and Birchmeier, C. and Wiese, S. and Sendtner, M. and Kawabe, H. and Kishimoto-Suga, M. and Brose, N. and Baumgart, J. and Geist, B. and Aoki, J. and Savaskan, N.E. and Braeuer, A.U. and Chun, J. and Ninnemann, O. and Schmitz, D. and Nitsch, R.
Cell 138
(6): 1222-12235.
18 September 2009
Insm1 (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the vertebrate hindbrain.
Jacob, J. and Storm, R. and Castro, D.S. and Milton, C. and Pla, P. and Guillemot, F. and Birchmeier, C. and Briscoe, J.
Development 136
(14): 2477-2485.
July 2009
c-Met confers protection against chronic liver tissue damage and fibrosis progression after bile-duct-ligation in mice.
Giebeler, A. and Boekschoten, M.V. and Klein, C. and Borowiak, M. and Birchmeier, C. and Gassler, N. and Wasmuth, H.E. and Mueller, M. and Trautwein, C. and Streetz, K.L.
Gastroenterology 137
(1): 297-308.
July 2009
Sensory axon-derived neuregulin-1 is required for axoglial signaling and normal sensory function but not for long-term axon maintenance.
Fricker, F.R. and Zhu, N. and Tsantoulas, C. and Abrahamsen, B. and Nassar, M.A. and Thakur, M. and Garratt, A.N. and Birchmeier, C. and McMahon, S.B. and Wood, J.N. and Bennett, D.L.
Journal of Neuroscience 29
(24): 7667-7678.
17 June 2009
The small G-proteins Rac1 and Cdc42 are essential for myoblast fusion in the mouse.
Vasyutina, E. and Martarelli, B. and Brakebusch, C. and Wende, H. and Birchmeier, C.
Proceedings of the National Academy of Sciences of the United States of America 106
(22): 8935-8940.
2 June 2009
Hepatocarcinogenesis in mice with a conditional knockout of the hepatocyte growth factor receptor c-Met.
Marx-Stoelting, P. and Borowiak, M. and Knorpp, T. and Birchmeier, C. and Buchmann, A. and Schwarz, M.
International Journal of Cancer 124
(8): 1767-1772.
15 April 2009
The effects of alpha-secretase ADAM10 on the proteolysis of neuregulin-1.
Freese, C. and Garratt, A.N. and Fahrenholz, F. and Endres, K.
FEBS Journal 276
(6): 1568-1580.
March 2009
The bHLH transcription factor Olig3 marks the dorsal neuroepithelium of the hindbrain and is essential for the development of brainstem nuclei.
Storm, R. and Cholewa-Waclaw, J. and Reuter, K. and Broehl, D. and Sieber, M. and Treier, M. and Mueller, T. and Birchmeier, C.
Development 136
(2): 295-305.
January 2009
Neuregulin-1, a key axonal signal that drives Schwann cell growth and differentiation.
Birchmeier, C. and Nave, K.A.
Glia 56
(14): 1491-1497.
1 November 2008
A transcriptional network coordinately determines transmitter and peptidergic fate in the dorsal spinal cord.
Broehl, D. and Strehle, M. and Wende, H. and Hori, K. and Bormuth, I. and Nave, K.A. and Mueller, T. and Birchmeier, C.
Developmental Biology 322
(2): 381-393.
15 October 2008
Insulinoma-associated 1 has a panneurogenic role and promotes the generation and expansion of Basal progenitors in the developing mouse neocortex.
Farkas, L.M. and Haffner, C. and Giger, T. and Khaitovich, P. and Nowick, K. and Birchmeier, C. and Paeaebo, S. and Huttner, W.B.
Neuron 60
(1): 40-55.
9 October 2008
Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4.
Caubit, X. and Lye, C.M. and Martin, E. and Core, N. and Long, D.A. and Vola, C. and Jenkins, D. and Garratt, A.N. and Skaer, H. and Woolf, A.S. and Fasano, L.
Development 135
(19): 3301-3310.
October 2008
Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system.
Brinkmann, B.G. and Agarwal, A. and Sereda, M.W. and Garratt, A.N. and Mueller, T. and Wende, H. and Stassart, R.M. and Nawaz, S. and Humml, C. and Velanac, V. and Radyushkin, K. and Goebbels, S. and Fischer, T.M. and Franklin, R.J. and Lai, C. and Ehrenreich, H. and Birchmeier, C. and Schwab, M.H. and Nave, K.A.
Neuron 59
(4): 581-595.
28 August 2008
Insm1 (IA-1) is a crucial component of the transcriptional network that controls differentiation of the sympatho-adrenal lineage.
Wildner, H. and Gierl, M.S. and Strehle, M. and Pla, P. and Birchmeier, C.
Development 135
(3): 473-81.
February 2008
A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling.
Hori, K. and Cholewa-Waclaw, J. and Nakada, Y. and Glasgow, S.M. and Masui, T. and Henke, R.M. and Wildner, H. and Martarelli, B. and Beres, T.M. and Epstein, J.A. and Magnuson, M.A. and Macdonald, R.J. and Birchmeier, C. and Johnson, J.E.
Genes & Development 22
(2): 166-178.
15 January 2008
Nociceptive tuning by stem cell factor/c-Kit signaling.
Milenkovic, N. and Frahm, C. and Gassmann, M. and Griffel, C. and Erdmann, B. and Birchmeier, C. and Lewin, G.R. and Garratt, A.N.
Neuron 56
(5): 893-906.
6 December 2007
A mutation of keratin 18 within the coil 1A consensus motif causes widespread keratin aggregation but cell type-restricted lethality in mice.
Hesse, M. and Grund, C. and Herrmann, H. and Broehl, D. and Franz, T. and Omary, M.B. and Magin, T.M.
Experimental Cell Research 313
(14): 3127-3140.
15 August 2007
Prolonged Sox4 expression in oligodendrocytes interferes with normal myelination in the central nervous system.
Potzner, M.R. and Griffel, C. and Luetjen-Drecoll, E. and Boesl, M.R. and Wegner, M. and Sock, E.
Molecular and Cellular Biology 27
(15): 5316-5326.
August 2007
Notch function in myogenesis.
Vasyutina, E. and Lenhard, D.C. and Birchmeier, C.
Cell Cycle 6
(12): 1451-1454.
15 June 2007
Lbx1 acts as a selector gene in the fate determination of somatosensory and viscerosensory relay neurons in the hindbrain.
Sieber, M.A. and Storm, R. and Martinez-de-la-Torre, M. and Mueller, T. and Wende, H. and Reuter, K. and Vasyutina, E. and Birchmeier, C.
Journal of Neuroscience 27
(18): 4902-4909.
2 May 2007
c-Met is essential for wound healing in the skin.
Chmielowiec, J. and Borowiak, M. and Morkel, M. and Stradal, T. and Munz, B. and Werner, S. and Wehland, J. and Birchmeier, C. and Birchmeier, W.
Journal of Cell Biology 177
(1): 151-162.
9 April 2007
RBP-J (Rbpsuh) is essential to maintain muscle progenitor cells and to generate satellite cells.
Vasyutina, E. and Lenhard, D.C. and Wende, H. and Erdmann, B. and Epstein, J.A. and Birchmeier, C.
Proceedings of the National Academy of Sciences of the United States of America 104
(11): 4443-4448.
13 March 2007
Bmp and Wnt/beta-catenin signals control expression of the transcription factor Olig3 and the specification of spinal cord neurons.
Zechner, D. and Muller, T. and Wende, H. and Walther, I. and Taketo, M.M. and Crenshaw, E.B. and Treier, M. and Birchmeier, W. and Birchmeier, C.
Developmental Biology 303
(1): 181-190.
1 March 2007
Notch signaling is essential for ventricular chamber development.
Grego-Bessa, J. and Luna-Zurita, L. and del Monte, G. and Bolos, V. and Melgar, P. and Arandilla, A. and Garratt, A.N. and Zang, H. and Mukouyama, Y.S. and Chen, H. and Shou, W. and Ballestar, E. and Esteller, M. and Rojas, A. and Perez-Pomares, J.M. and de la Pompa, J.L.
Developmental Cell 12
(3): 415-429.
March 2007
Post-transcriptional regulation of the let-7 microRNA during neural cell specification.
Wulczyn, F.G. and Smirnova, L. and Rybak, A. and Brandt, C. and Kwidzinski, E. and Ninnemann, O. and Strehle, M. and Seiler, A. and Schumacher, S. and Nitsch, R.
FASEB Journal 21
(2): 415-426.
February 2007
Control of peripheral nerve myelination by the β-secretase BACE1.
Willem, M. and Garratt, A.N. and Novak, B. and Citron, M. and Kaufmann, S. and Rittger, A. and Destrooper, B. and Saftig, P. and Birchmeier, C. and Haass, C.
Science 314
(5799): 664-666.
27 October 2006
The Zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic beta cells and intestinal endocrine cells.
Gierl, M.S. and Karoulias, N. and Wende, H. and Strehle, M. and Birchmeier, C.
Genes & Development 20
(17): 2465-2478.
1 September 2006
dILA neurons in the dorsal spinal cord are the product of terminal and non-terminal asymmetric progenitor cell divisions, and require Mash1 for their development.
Wildner, H. and Mueller, T. and Cho, S.H. and Broehl, D. and Cepko, C.L. and Guillemot, F. and Birchmeier, C.
Development 133
(11): 2105-2113.
1 June 2006
Tangential neuronal migration controls axon guidance: a role for neuregulin-1 in thalamocortical axon navigation.
Lopez-Bendito, G. and Cautinat, A. and Sanchez, J.A. and Bielle, F. and Flames, N. and Garratt, A.N. and Talmage, D.A. and Role, L.W. and Charnay, P. and Marin, O. and Garel, S.
Cell 125
(1): 127-142.
7 April 2006
ErbB2 signaling in Schwann cells is mostly dispensable for maintenance of myelinated peripheral nerves and proliferation of adult Schwann cells after injury.
Atanasoski, S. and Scherer, S.S. and Sirkowski, E. and Leone, D. and Garratt, A.N. and Birchmeier, C. and Suter, U.
Journal of Neuroscience 26
(7): 2124-2131.
15 February 2006
The homeodomain transcription factor Gbx1 identifies a subpopulation of late-born GABAergic interneurons in the developing dorsal spinal cord.
John, A. and Wildner, H. and Britsch, S.
Developmental Dynamics 234
(3): 767-771.
28 September 2005
CXCR4 and Gab1 cooperate to control the development of migrating muscle progenitor cells.
Vasyutina, E. and Stebler, J. and Brand-Saberi, B. and Schulz, S. and Raz, E. and Birchmeier, C.
Genes & Development 19
(18): 2187-2198.
15 September 2005
Dual functionality of the anti-beta1 integrin antibody, 12G10, exemplifies agonistic signalling from the ligand binding pocket of integrin adhesion receptors.
Humphries, J.D. and Schofield, N.R. and Mostafavi-Pour, Z. and Green, L.J. and Garratt, A.N. and Mould, A.P. and Humphries, M.J.
Journal of Biological Chemistry 280
(11): 10234-10243.
18 March 2005
A role for E2F6 in the restriction of male-germ-cell-specific gene expression.
Pohlers, M. and Truss, M. and Frede, U. and Scholz, A. and Strehle, M. and Kuban, R.J. and Hoffmann, B. and Morkel, M. and Birchmeier, C. and Hagemeier, C.
Current Biology 15
(11): 1051-1057.
1 January 2005
The bHLH factor Olig3 coordinates the specification of dorsal neurons in the spinal cord.
Muller, T. and Anlag, K. and Wildner, H. and Britsch, S. and Treier, M. and Birchmeier, C.
Genes & Development 19
(6): 733-743.
1 January 2005
Activating Met mutations produce unique tumor profiles in mice with selective duplication of the mutant allele.
Graveel, C. and Su, Y. and Koeman, J. and Wang, L.M. and Tessarollo, L. and Fiscella, M. and Birchmeier, C. and Swiatek, P. and Bronson, R. and Vande Woude, G.F.
Proceedings of the National Academy of Sciences of the United States of America 101
(49): 17198-17203.
7 December 2004
Short- and long-range attraction of cortical GABAergic interneurons by neuregulin-1.
Flames, N. and Long, J.E. and Garratt, A.N. and Fischer, T.M. and Gassmann, M. and Birchmeier, C. and Lai, C. and Rubenstein, J.L. and Marin, O.
Neuron 44
(2): 251-261.
14 October 2004
Axonal neuregulin-1 regulates myelin sheath thickness.
Michailov, G.V. and Sereda, M.W. and Brinkmann, B.G. and Fischer, T.M. and Haug, B. and Birchmeier, C. and Role, L. and Lai, C. and Schwab, M.H. and Nave, K.A.
Science 304
(5671): 700-703.
30 April 2004
Met provides essential signals for liver regeneration.
Borowiak, M. and Garratt, A.N. and Wuestefeld, T. and Strehle, M. and Trautwein, C. and Birchmeier, C.
Proceedings of the National Academy of Sciences of the United States of America 101
(29): 10608-10613.
1 January 2004
beta-catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system.
Zechner, D. and Fujita, Y. and Huelsken, J. and Mueller, T. and Walther, I. and Taketo, M.M. and Crenshaw, E.B. and Birchmeier, W. and Birchmeier, C.
Developmental Biology 258
(2): 406-418.
15 June 2003
Acquisition of neuronal and glial markers by neural crest-derived cells in the mouse intestine.
Young, H.M. and Bergner, A.J. and Mueller, T.
Journal of Comparative Neurology 456
(1): 1-11.
27 January 2003
A role for Neuregulin1 signaling in muscle spindle differentiation.
Hippenmeyer, S. and Shneider, N.A. and Birchmeier, C. and Burden, S.J. and Jessell, T.M. and Arber, S.
Neuron 36
(6): 1035-1049.
19 December 2002
Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy.
Özcelik, C. and Erdmann, B. and Pilz, B. and Wettschureck, N. and Britsch, S. and Hübner, N. and Chien, K.R. and Birchmeier, C. and Garratt, A.N.
Proceedings of the National Academy of Sciences of the United States of America 99
(13): 8880-8885.
25 June 2002
Sensory nerves determine the pattern of arterial differentiation and blood vessel branching in the skin.
Mukouyama, Y. and Shin, D. and Britsch, S. and Taniguchi, M. and Anderson, D.J.
Cell 109
(6): 693-705.
14 June 2002
The homeodomain factor Lbx1 distinguishes two major programs of neuronal differentiation in the dorsal spinal cord.
Müller, T. and Brohmann, H. and Pierani, A. and Heppenstall, P.A. and Lewin, G.R. and Jessell, T.M. and Birchmeier, C.
Neuron 34
(4): 551-562.
16 May 2002
The breast proto-oncogene, HRGalpha regulates epithelial proliferation and lobuloalveolar development in the mouse mammary gland.
Li, L. and Cleary, S. and Mandarano, M.A. and Long, W.W. and Birchmeier, C. and Jones, F.E.
Oncogene 21
: 4900-4907.
1 January 2002
Genomics boosts mouse molecular genetics.
Birchmeier, C. and Treier, M.
Trends in Genetics 17
(12): 691-692.
1 December 2001
Negative regulation of Ros receptor tyrosine kinase signaling: An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1.
Keilhack, H. and Mueller, M. and Boehmer, S.A. and Frank, C. and Weidner, K.M. and Birchmeier, W. and Ligensa, T. and Berndt, A. and Kosmehl, H. and Gunther, B. and Mueller, T. and Birchmeier, C. and Boehmer, F.D.
Journal of Cell Biology 152
(2): 325-334.
22 January 2001
Patterning of muscle acetylcholine receptor gene expression in the absence of motor innervation.
Yang, X. and Arber, S. and William, C. and Li, L. and Tanabe, Y. and Jessell, T.M. and Birchmeier, C. and Burden, S.J.
Neuron 30
(2): 399-410.
1 January 2001
The transcription factor Sox10 is a key regulator of peripheral glial development.
Britsch, S. and Goerich, D.E. and Riethmacher, D. and Peirano, R.I. and Rossner, M. and Nave, K.A. and Birchmeier, C. and Wegner, M.
Genes & Development 15
(1): 66-78.
1 January 2001
Genes that control the development of migrating muscle precursor cells.
Birchmeier, C. and Brohmann, H.
Current Opinion in Cell Biology 12
(6): 725-730.
1 December 2000
E-cadherin and adenomatous polyposis coli mutations are synergistic in intestinal tumor initiation in mice.
Smits, R. and Ruiz, P. and Diaz-Cano, S. and Luz, A. and Jagmohan-Changur, S. and Breukel, C. and Birchmeier, C. and Birchmeier, W. and Fodde, R.
Gastroenterology 119
(4): 1045-1053.
1 October 2000
Essential role of Gab1 for signaling by the c-Met receptor in vivo.
Sachs, M. and Brohmann, H. and Zechner, D. and Mueller, T. and Huelsken, J. and Walther, I. and Schaeper, U. and Birchmeier, C. and Birchmeier, W.
Journal of Cell Biology 150
(6): 1375-1384.
18 September 2000
The branchial arches and HGF are growth-promoting and chemoattractant for cranial motor axons.
Caton, A. and Hacker, A. and Naeem, A. and Livet, J. and Maina, F. and Bladt, F. and Klein, R. and Birchmeier, C. and Guthrie, S.
Development 127
(8): 1751-1766.
1 April 2000
A dual role of erbB2 in myelination and in expansion of the Schwann cell precursor pool.
Garratt, A.N. and Voiculescu, O. and Topilko, P. and Charnay, P. and Birchmeier, C.
Journal of Cell Biology 148
(5): 1035-1046.
6 March 2000
Requirement for beta-catenin in anterior-posterior axis formation in mice.
Huelsken, J. and Vogel, R. and Brinkmann, V. and Erdmann, B. and Birchmeier, C. and Birchmeier, W.
Journal of Cell Biology 148
(3): 567-578.
7 February 2000
The role of Lbx1 in migration of muscle precursor cells.
Brohmann, H. and Jagla, K. and Birchmeier, C.
Development 127
(2): 437-445.
1 January 2000
A role of the cryptic gene in the correct establishment of the left-right axis.
Gaio, U. and Schweickert, A. and Fischer, A. and Garratt, A.N. and Mueller, T. and Oezcelik, C. and Lankes, W. and Strehle, M. and Britsch, S. and Blum, M. and Birchmeier, C.
Current Biology 9
(22): 1339-1342.
18 November 1999
Peripheral nervous system defects in erbB2 mutants following genetic rescue of heart development.
Woldeyesus, M.T. and Britsch, S. and Riethmacher, D. and Xu, L. and Sonnenberg-Riethmacher, E. and Abou-Rebyeh, F. and Harvey, R. and Caroni, P. and Birchmeier, C.
Genes & Development 13
: 2538-2548.
1 October 1999
MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis.
Kotlyarov, A. and Neininger, A. and Schubert, C. and Eckert, R. and Birchmeier, C. and Volk, H.D. and Gaestel, M.
Nature Cell Biology 1
: 94-97.
1 June 1999
The role of SF/HGF and c-Met in the development of skeletal muscle.
Dietrich, S. and Abou-Rebyeh, F. and Brohmann, H. and Bladt, F. and Yamaai, T. and Lumsden, A. and Brand-Saberi, B. and Birchmeier, C.
Development 126
: 1621-1629.
1 April 1999
Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinase.
Birchmeier, C. and Gherardi, E.
Trends in Cell Biology 8
(10): 404-410.
1 October 1998
Engineered mutants of HGF/SF with reduced binding to heparan sulphate proteoglycans, decreased clearance and enhanced activity in vivo.
Hartmann, G. and Prospero, T. and Brinkmann, V. and Ozcelik, O. and Winter, G. and Hepple, J. and Batley, S. and Bladt, F. and Sachs, M. and Birchmeier, C. and Birchmeier, W. and Gherardi, E.
Current Biology 8
(3): 125-134.
29 January 1998
Sustained long-term potentiation and anxiety in mice lacking the Mas protooncogene.
Walther, T. and Balschun, D. and Voigt, J.P. and Fink, H. and Zuschratter, W. and Birchmeier, C. and Ganten, D. and Bader, M.
Journal of Biological Chemistry 273
: 11867-11873.
1 January 1998
The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system.
Britsch, S. and Li, L. and Kirchhoff, S. and Theuring, F. and Brinkmann, V. and Birchmeier, C. and Riethmacher, D.
Genes & Development 12
: 1825-1836.
1 January 1998
Hepatocyte growth factor/scatter factor is an axonal chemoattractant and a neurotrophic factor for spinal motor neurons.
Ebens, A. and Brose, K. and Leonardo, E.D. and Hanson, M.G. and Bladt, F. and Birchmeier, C. and Barres, B.A. and Tessierlavigne, M.
Neuron 17
(6): 1157-1172.
1 December 1997
Severe neuropathies in mice with targeted mutations in the ErbB3 receptor.
Riethmacher, D. and Sonnenberg-Riethmacher, E. and Brinkmann, V. and Yamaai, T. and Lewin, G.R. and Birchmeier, C.
Nature 389
(6652): 725-730.
16 October 1997
Isoform specific expression and function of neuregulin.
Meyer, D. and Yamaai, T. and Garratt, A. and Riethmacher-Sonnenberg, E. and Kane, D. and Theill, L.E. and Birchmeier, C.
Development 124
(18): 3575-3586.
September 1997
Met -/- kidneys express epithelial cells that chemotax and form tubules in response to EGF receptor ligands.
Kjelsberg, C. and Sakurai, H. and Spokes, K. and Birchmeier, C. and Drummond, I. and Nigam, S. and Cantley, L.G.
American Journal of Physiology Renal Physiology 272
: F222-F228.
1 January 1997
The functions of HGF/SF and its receptor, the c-Met tyrosine kinase, in mammalian development.
Birchmeier, C. and Bladt, F. and Yamaai, T.
Ciba Foundation Symposia 212
: 169-177, discussion 177-82..
1 January 1997
Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart.
Ruiz, P. and Brinkmann, V. and Ledermann, B. and Behrend, M. and Grund, C. and Thalhammer, C. and Vogel, F. and Birchmeier, C. and Guenthert, U. and Franke, W.W. and Birchmeier, W.
Journal of Cell Biology 135
(1): 215-225.
October 1996
Scatter factor hepatocyte growth factor (sf/hgf) induces emigration of myogenic cells at interlimb level in vivo.
Brand-Saberi, B. and Mueller, T.S. and Wilting, J. and Christ, B. and Birchmeier, C.
Developmental Biology 179
: 303-308.
1 January 1996
The c-ros tyrosine kinase receptor controls regionalization and differentiation of epithelial cells in the epididymis.
Sonnenberg-Riethmacher, E. and Walter, B. and Riethmacher, D. and Goedecke, S. and Birchmeier, C.
Genes & Development 10
(10): 1184-1193.
1 January 1996
Multiple essential functions of neuregulin in development.
Meyer, D. and Birchmeier, C.
Nature 378
(6555): 386-390.
23 November 1995
Sequential requirement of hepatocyte growth factor and neuregulin in the morphogenesis and differentiation of the mammary gland.
Yang, Y. and Spitzer, E. and Meyer, D. and Sachs, M. and Niemann, C. and Hartmann, G. and Weidner, K.M. and Birchmeier, C. and Birchmeier, W.
Journal of Cell Biology 131
(1): 215-226.
October 1995
Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud.
Bladt, F. and Riethmacher, D. and Isenmann, S. and Aguzzi, A. and Birchmeier, C.
Nature 376
(6543): 768-771.
31 August 1995
Scatter factor/hepatocyte growth factor is essential for liver development.
Schmidt, C. and Bladt, F. and Goedecke, S. and Brinkmann, V. and Zschiesche, W. and Sharpe, M. and Gherardi, E. and Birchmeier, C.
Nature 373
(6515): 699-702.
23 February 1995
A targeted mutation in the mouse E-cadherin gene results in defective preimplantation development.
Riethmacher, D. and Brinkmann, V. and Birchmeier, C.
Proceedings of the National Academy of Sciences of the United States of America 92
(3): 855-859.
31 January 1995
Biochemical and functional characterization of the murine ros protooncogene.
Riethmacher, D. and Langholz, O. and Goedecke, S. and Sachs, M. and Birchmeier, C.
Oncogene 9
(12): 3617-3626.
December 1994
Distinct isoforms of neuregulin are expressed in mesenchymal and neuronal cells during mouse development.
Meyer, D. and Birchmeier, C.
Proceedings of the National Academy of Sciences of the United States of America 91
: 1064-1068.
1 January 1994
Mesenchymal-epithelial transitions.
Birchmeier, W. and Birchmeier, C.
BioEssays 16
: 305-307.
1 January 1994
Differential expression of neurotrophin receptors during renal development.
Durbeej, M. and Soederstroem, S. and Ebendal, T. and Birchmeier, C. and Ekblom, P.
Development 119
(4): 977-989.
December 1993
Scatter factor/hepatocyte growth factor and its receptor, the c-met tyrosine kinase, can mediate a signal exchange between mesenchyme and epithelia during mouse development.
Sonnenberg, E. and Meyer, D. and Weidner, K.M. and Birchmeier, C.
Journal of Cell Biology 123
(1): 223-235.
1 October 1993
Characterization and expression analysis of the murine rck gene - a protein-kinase with a potential function in sensory cells.
Bladt, F. and Birchmeier, C.
Differentiation 53
: 115-122.
1 January 1993
Book Section
Neural development.
Mueller, T.
In:
Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine ; Vol. 2.
Springer, Berlin [u.a.], 1258-1266.
ISBN 3-540-44244-8
2006
Transgenic and knock-out animals.
Britsch, S.
In:
Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine ; Vol. 2.
Springer, Berlin [u.a.], 1900-1903.
ISBN 3-540-44244-8
2006
Tiermodelle in der biomedizinischen Forschung.
Britsch, S. and Strehle, M. and Birchmeier, C.
In:
Grundlagen der Molekularen Medizin.
Molekulare Medizin
.
Springer, Berlin [u.a.], 299-339.
ISBN 3-540-43207-8
1 January 2003
10. Tyrosine kinase receptors as driving forces for growth, motility and differentiation of epithelial cells.
Birchmeier, W. and Birchmeier, C. and Brinkmann, V. and Niemann, C.
In:
Epithelial Morphogenesis in Development and Disease.
Cell Adhesion and Communication
.
Harwood Acad. Publ., Amsterdam [u.a.], 217-231.
1 January 1999
Morphogenesis of epithelial cells.
Birchmeier, C. and Riethmacher, D. and Brinkmann, V.
In:
Adhesion Molecules in Health and Disease.
Marcel Dekker,Inc., New York, 205-222.
1 January 1997
Tiermodelle in der biomedizinischen Forschung.
Birchmeier, C. and Bladt, F. and Britsch, S.
In:
Molekular- und Zellbiologische Grundlagen.
Handbuch der Molekularen Medizin ; 1
.
Springer, Berlin [u.a.], 338-358.
1 January 1997
Epithelial-mesenchymal transitions in development and tumor progression.
Birchmeier, W. and Birchmeier, C.
In:
Epithelial-Mesenchymal Interactions in Cancer.
Birkhaeuser, Basel, 1-15.
1 January 1995
Expression of the met-receptor and its ligand, HGF-SF during mouse embryogenesis.
Sonnenberg, E. and Weidner, K.M. and Birchmeier, C.
In:
Hepatocyte Growth Factor-Scatter Factor (HGF-SF) and the C-Met-Receptor.
Birkhaeuser, Basel [u.a.], 381-394.
1 January 1993
Book
Epithelial Morphogenesis in Development and Disease.
Birchmeier, W. and Birchmeier, C.
Cell Adhesion and Communication
.
Harwood Acad. Publ., Amsterdam [u.a.].
1 January 1999
Thesis
Die Funktion des Transkriptionsfaktors Olig3 in der Entwicklung des Hirnstamms [The function of the transcription factor Olig3 in the development of the hindbrain].
Reuter, K.
UNSPECIFIED thesis, UNSPECIFIED.
14 July 2006
Genetische Analyse des Tyrosinkinase-Rezeptors ErbB2.
Woldeyesus, M.T.
UNSPECIFIED thesis, UNSPECIFIED.
14 February 2001
Patent
Verfahren zur Herstellung von universell einsetzbaren Feeder-Matrix-Schalen und ihre Verwendung zur Kultivierung von embryonalen Stammzellen jeglicher Art.
Garratt, A. and Buchert, S.
DE19929469A1.
28 December 2000
Review
Transcription factors regulating the specification of brainstem respiratory neurons.
Xia, Y. and Cui, K. and Alonso, A. and Lowenstein, E.D. and Hernandez-Miranda, L.R.
Frontiers in Molecular Neuroscience 15
: 1072475.
29 November 2022
Regulation of early cerebellar development.
Lowenstein, E. and Cui, K. and Hernandez-Miranda, L.R.
FEBS Journal 290
(11): 2786-2804.
June 2022
An oscillatory network controlling self-renewal of skeletal muscle stem cells.
Lahmann, I. and Zhang, Y. and Baum, K. and Wolf, J. and Birchmeier, C.
Experimental Cell Research 409
(2): 112933.
15 December 2021
Nonclinical data supporting orphan medicinal product designations in the area of rare infectious diseases.
Sheean, M.E. and Malikova, E. and Duarte, D. and Capovilla, G. and Fregonese, L. and Hofer, M. and Magrelli, A. and Mariz, S. and Mendez-Hermida, F. and Nistico, R. and Leest, T. and Sipsas, N.V. and Tsigkos, S. and Vitezic, D. and Larsson, K. and Sepodes, B. and Stoyanova-Beninska, V.
Drug Discovery Today 25
(2): 274-291.
February 2020
Establishing rarity in the context of orphan medicinal product designation in the European Union.
Tsigkos, S. and Hoffer, M.P. and Sheean, M.E. and Mariz, S. and Larsson, K. and Naumann-Winter, F. and Fregonese, L. and Sepodes, B.
Drug Discovery Today 23
(3): 681-686.
March 2018
Nonclinical data supporting orphan medicinal product designations: lessons from rare neurological conditions.
Sheean, M.E. and Stoyanova-Beninska, V. and Capovilla, G. and Duarte, D. and Hofer, M.P. and Hoffmann, M. and Magrelli, A. and Mariz, S. and Tsigkos, S. and Shaili, E. and Polsinelli, B. and Ricciardi, M. and Bonelli, M. and Balabanov, P. and Larsson, K. and Sepodes, B.
Drug Discovery Today 23
(1): 26-48.
January 2018
The dorsal spinal cord and hindbrain: from developmental mechanisms to functional circuits.
Hernandez-Miranda, L.R. and Müller, T. and Birchmeier, C.
Developmental Biology 432
(1): 34-42.
1 December 2017
Neuregulin/ErbB signaling in developmental myelin formation and nerve repair.
Birchmeier, C. and Bennett, D.L.H.
Current Topics in Developmental Biology 116
: 45-64.
2016
Targeting MET in cancer: rationale and progress.
Gherardi, E. and Birchmeier, W. and Birchmeier, C. and Woude, G.V.
Nature Reviews Cancer 12
(2): 89-103.
February 2012
Nrg1/ErbB signaling networks in Schwann cell development and myelination.
Newbern, J. and Birchmeier, C.
Seminars in Cell & Developmental Biology 21
(9): 922-988.
December 2010
The tyrosine phosphatase Shp2 in development and cancer.
Grossmann, K.S. and Rosario, M. and Birchmeier, C. and Birchmeier, W.
Advances in Cancer Research 106
: 53-89.
2010
ErbB receptors and the development of the nervous system.
Birchmeier, C.
Experimental Cell Research 315
(4): 611-618.
15 February 2009
The development of migrating muscle precursor cells.
Vasyutina, E. and Birchmeier, C.
Anatomy and Embryology 211
(Suppl.): S37-S41.
December 2006
Met, metastasis, motility and more.
Birchmeier, C. and Birchmeier, W. and Gherardi, E. and Vande Woude, G.F.
Nature Reviews Molecular Cell Biology 4
(12): 915-925.
December 2003
ErbB2 pathways in heart and neural diseases.
Garratt, A.N. and Ozcelik, C. and Birchmeier, C.
Trends in Cardiovascular Medicine 13
(2): 80-86.
February 2003
Trastuzumab cardiotoxicity: Speculations regarding pathophysiology and targets for further study.
Schneider, J.W. and Chang, A.Y. and Garratt, A.
Seminars in Oncology 29
(3): 22-28.
June 2002
Neuregulin, a factor with many functions in the life of schwann cell.
Garratt, A.N. and Britsch, S. and Birchmeier, C.
BioEssays 22
(11): 987-996.
November 2000
Epithelial differentiation and the control of metastasis in carcinomas.
Birchmeier, W. and Behrens, J. and Weidner, K.M. and Huelsken, J. and Birchmeier, C.
Current Topics in Microbiology and Immunology
: 117-135.
1 January 1996
Epithelial-mesenchymal transitions in cancer progression.
Birchmeier, C. and Birchmeier, W. and Brand-Saberi, B.
Acta Anatomica 156
: 217-226.
1 January 1996
Factors controlling growth, motility, and morphogenesis of normal and malignant epithelial cells.
Birchmeier, C. and Meyer, D. and Riethmacher, D.
International Review of Cytology 160
: 221-266.
1 January 1995
Tyrosine kinase receptors in the control of epithelial growth and morphogenesis during development.
Birchmeier, C. and Sonnenberg, E. and Weidner, K.M. and Walter, B.
BioEssays 15
: 185-190.
1 January 1993
Molecular aspects of mesenchymal-epithelial interactions.
Birchmeier, C. and Birchmeier, W.
Annual Review of Cell Biology 9
: 511-540.
1993
Editorial
Regulation of developmental tempo in different vertebrate species.
Birchmeier, C.
Cell Stem Cell 30
(7): 907-908.
6 July 2023
Defining orphan conditions in the context of the European orphan regulation: challenges and evolution.
O'Connor, D.J. and Sheean, M.E. and Hofer, M.P. and Tsigkos, S. and Mariz, S. and Fregonese, L. and Larsson, K. and Hivert, V. and Westermark, K. and Naumann-Winter, F. and Stoyanova-Beninska, V. and Barišić, I. and Capovilla, G. and Magrelli, A. and Sepodes, B.
Nature Reviews Drug Discovery 18
(7): 479-480.
July 2019
Diversity in the lab makes me a better scientist.
Lowenstein, E.
Scientific American 320
(1): 8.
January 2019
CO(2) in the spotlight.
Hernandez-Miranda, L.R. and Birchmeier, C.
eLife 4
: e08086.
13 May 2015
Preface.
Birchmeier, C.
Current Topics in Developmental Biology 97
: xi-xii.
2011
Development and more.
Birchmeier, C.
Seminars in Cell & Developmental Biology 21
(8): 812-813.
October 2010
A fresh breeze from the ivory tower.
Birchmeier, C.
Current Opinion in Cell Biology 21
(6): 725-726.
December 2009
"To erb-B or not to erb-B..." Neuregulin-1/ErbB signaling in heart development and function.
Garratt, A.N.
Journal of Molecular and Cellular Cardiology 41
(2): 215-218.
August 2006
Cell differentiation.
Rosenthal, N. and Birchmeier, C.
Current Opinion in Cell Biology 12
: 717-718.
1 December 2000
Preprint
An executive center for the intake of liquids.
Dempsey, B. and Sungeelee, S. and Bokiniec, P. and Chettouh, Z. and Diem, S. and Autran, S. and Harrell, E.R. and Poulet, J.F.A. and Birchmeier, C. and Carrey, H. and Genovesio, A. and McMullan, S. and Goridis, C. and Fortin, G. and Brunet, J.F.
bioRxiv
: 2021.07.02.450862.
4 July 2021
Fructose 1,6-bisphosphate sensing by pyruvate kinase isozymes M2 (PKM2) controls MyoD stability and myogenic differentiation.
Kim, M. and Zhang, Y. and Birchmeier, C.
bioRxiv
: 2020.12.22.424062.
22 December 2020
Olig3 acts as a master regulator of cerebellar development.
Lowenstein, E.D. and Rusanova, A. and Stelzer, J. and Hernaiz-Llorens, M. and Schroer, A.E. and Epifanova, E. and Bladt, F. and Isik, E.G. and Jia, S. and Tarabykin, V. and Hernandez-Miranda, L.R.
bioRxiv
: 2020.10.10.334615.
10 October 2020
Single-nucleus transcriptomics reveals functional compartmentalization in syncytial skeletal muscle cells.
Kim, M. and Franke, V. and Brandt, B. and Spuler, S. and Akalin, A. and Birchmeier, C.
bioRxiv
: 2020.04.14.041665.
15 April 2020
EHD2-mediated restriction of caveolar dynamics regulates cellular lipid uptake.
Matthäus, C. and Lahmann, I. and Kunz, S. and Jonas, W. and Alves Melo, A. and Lehmann, M. and Larsson, E. and Lundmark, R. and Kern, M. and Blüher, M. and Müller, D.N. and Haucke, V. and Schürmann, A. and Birchmeier, C. and Daumke, O.
bioRxiv
: 511709.
7 March 2019
Cell fixation and preservation for droplet-based single-cell transcriptomics.
Alles, J. and Karaiskos, N. and Praktiknjo, S. and Grosswendt, S. and Wahle, P. and Ruffault, P.L. and Ayoub, S. and Schreyer, L. and Boltengagen, A. and Birchmeier, C. and Zinzen, R. and Kocks, C. and Rajewsky, N.
bioRxiv
: 099473.
13 April 2017
This list was generated on Fri Apr 26 02:19:52 2024 CEST.
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