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The development of migrating muscle precursor cells

Item Type:Review
Title:The development of migrating muscle precursor cells
Creators Name:Vasyutina, E. and Birchmeier, C.
Abstract:A major subclass of hypaxial muscle groups is derived from long-range migrating precursor cells that delaminate from the dermomyotome. Migrating precursors are generated on particular axial levels only, i.e. occipitally, cervically, and on the levels of the fore and hind limbs. They express the homeobox gene Lbx1, which provides a useful marker for their visualization. In the mouse, migrating precursor cells give rise to muscles of the extremities, the hypoglossal chord, and the diaphragm. We discuss here the development of this migrating lineage, which critically depends on the correct specification of the precursors in the dermomyotome, their delamination and correct migration. Finally, proliferation at the targets is essential to ensure a correct size of the precursor pool and of the muscle that derives thereof.
Keywords:Body Patterning, Cell Lineage, Cell Movement, Muscle Proteins, Muscles, Signal Transduction, Somites, Animals, Mice
Source:Anatomy and Embryology
Page Range:S37-S41
Date:December 2006
Official Publication:https://doi.org/10.1007/s00429-006-0118-9
PubMed:View item in PubMed

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