Browse by Research Team

2024

Molecular characterization of nodose ganglia development reveals a novel population of Phox2b+ glial progenitors in mice.
Lowenstein, E.D., Misios, A., Buchert, S. and Ruffault, P.L.
Journal of Neuroscience 44 (28): e1441232024. 10 July 2024

Genetic identification of medullary neurons underlying congenital hypoventilation.
Cui, K., Xia, Y., Patnaik, A., Salivara, A., Lowenstein, E.D., Isik, E.G., Knorz, A.L., Airaghi, L., Crotti, M., Garratt, A.N., Meng, F., Schmitz, D., Studer, M., Rijli, F.M., Nothwang, H.G., Rost, B.R., Strauß, U. and Hernandez-Miranda, L.R.
Science Advances 10 (25): eadj0720. 21 June 2024

The IgCAM BT-IgSF (IgSF11) is essential for connexin43-mediated astrocyte-astrocyte coupling in mice.
Pelz, L., Dossou, L., Kompier, N., Jüttner, R., Siemonsmeier, G., Meyer, N., Lowenstein, E.D., Lahmann, I., Kettenmann, H., Birchmeier, C. and Rathjen, F.G.
eNeuro 22 February 2024 (In Press)

Precise CRISPR-Cas9 gene repair in autologous memory T cells to treat familial hemophagocytic lymphohistiocytosis.
Li, X., Wirtz, T., Weber, T., Lebedin, M., Lowenstein, E.D., Sommermann, T., Zach, A., Yasuda, T., de la Rosa, K., Chu, V.T., Schulte, J.H., Müller, I., Kocks, C. and Rajewsky, K.
Science Immunology 9 (92): eadi0042. 2 February 2024

2023

Prox2 and Runx3 vagal sensory neurons regulate esophageal motility.
Lowenstein, E.D., Ruffault, P.L., Misios, A., Osman, K.L., Li, H., Greenberg, R.S., Thompson, R., Song, K., Dietrich, S., Li, X., Vladimirov, N., Woehler, A., Brunet, J.F., Zampieri, N., Kühn, R., Liberles, S.D., Jia, S., Lewin, G.R., Rajewsky, N., Lever, T.E. and Birchmeier, C.
Neuron 111 (14): 2184-2200.e7. 19 July 2023

Regulation of developmental tempo in different vertebrate species.
Birchmeier, C.
Cell Stem Cell 30 (7): 907-908. 6 July 2023

c-Maf-positive spinal cord neurons are critical elements of a dorsal horn circuit for mechanical hypersensitivity in neuropathy.
Frezel, N., Ranucci, M., Foster, E., Wende, H., Pelczar, P., Mendes, R., Ganley, R.P., Werynska, K., d'Aquin, S., Beccarini, C., Birchmeier, C., Zeilhofer, H.U. and Wildner, H.
Cell Reports 42 (4): 112295. 21 March 2023

Molecular characterization of the intact mouse muscle spindle using a multi-omics approach.
Bornstein, B., Heinemann-Yerushalmi, L., Krief, S., Adler, R., Dassa, B., Leshkowitz, D., Kim, M.C., Bewick, G., Banks, R.W. and Zelzer, E.
eLife 12 : e81843. 6 February 2023

Visualizing MyoD oscillations in muscle stem cells.
Lahmann, I. and Birchmeier, C.
Methods in Molecular Biology 2640 : 259-276. 2023

2022

Transcription factors regulating the specification of brainstem respiratory neurons.
Xia, Y., Cui, K., Alonso, A., Lowenstein, E.D. and Hernandez-Miranda, L.R.
Frontiers in Molecular Neuroscience 15 : 1072475. 29 November 2022

Molecular identity of proprioceptor subtypes innervating different muscle groups in mice.
Dietrich, S., Company, C., Song, K., Lowenstein, E.D., Riedel, L., Birchmeier, C., Gargiulo, G. and Zampieri, N.
Nature Communications 13 (1): 6867. 11 November 2022

Mafa-dependent GABAergic activity promotes mouse neonatal apneas.
Lecoin, L., Dempsey, B., Garancher, A., Bourane, S., Ruffault, P.L., Morin-Surun, M.P., Rocques, N., Goulding, M., Eychène, A., Pouponnot, C., Fortin, G. and Champagnat, J.
Nature Communications 13 (1): 3284. 7 June 2022

Regulation of early cerebellar development.
Lowenstein, E., Cui, K. and Hernandez-Miranda, L.R.
FEBS Journal 290 (11): 2786-2804. June 2022

SMER28 attenuates PI3K/mTOR signaling by direct inhibition of PI3K p110 delta.
Kirchenwitz, M., Stahnke, S., Prettin, S., Borowiak, M., Menke, L., Sieben, C., Birchmeier, C., Rottner, K., Stradal, T.E.B. and Steffen, A.
Cells 11 (10): 1648. 16 May 2022

2021

An oscillatory network controlling self-renewal of skeletal muscle stem cells.
Lahmann, I., Zhang, Y., Baum, K., Wolf, J. and Birchmeier, C.
Experimental Cell Research 409 (2): 112933. 15 December 2021

A medullary centre for lapping in mice.
Dempsey, B., Sungeelee, S., Bokiniec, P., Chettouh, Z., Diem, S., Autran, S., Harrell, E.R., Poulet, J.F.A., Birchmeier, C., Carey, H., Genovesio, A., McMullan, S., Goridis, C., Fortin, G. and Brunet, J.F.
Nature Communications 12 : 6307. 2 November 2021

Technologies for profiling the impact of genomic variants on transcription factor binding.
Leiz, J., Rutkiewicz, M., Birchmeier, C., Heinemann, U. and Schmidt-Ott, K.M.
Medizinische Genetik 33 (2): 147-155. 14 August 2021

Met and Cxcr4 cooperate to protect skeletal muscle stem cells against inflammation-induced damage during regeneration.
Lahmann, I., Griger, J., Chen, J.S., Zhang, Y., Schülke, M. and Birchmeier-Kohler, C.
eLife 10 : e57356. 5 August 2021

An executive center for the intake of liquids.
Dempsey, B., Sungeelee, S., Bokiniec, P., Chettouh, Z., Diem, S., Autran, S., Harrell, E.R., Poulet, J.F.A., Birchmeier, C., Carrey, H., Genovesio, A., McMullan, S., Goridis, C., Fortin, G. and Brunet, J.F.
bioRxiv : 2021.07.02.450862. 4 July 2021

Oscillations of Delta-like1 regulate the balance between differentiation and maintenance of muscle stem cells.
Zhang, Y., Lahmann, I., Baum, K., Shimojo, H., Mourikis, P., Wolf, J., Kageyama, R. and Birchmeier, C.
Nature Communications 12 (1): 1318. 26 February 2021

Olig3 regulates early cerebellar development.
Lowenstein, E.D., Rusanova, A., Stelzer, J., Hernaiz-Llorens, M., Schroer, A.E., Epifanova, E., Bladt, F., Isik, E.G., Buchert, S., Jia, S., Tarabykin, V. and Hernandez-Miranda, L.R.
eLife 10 : e64684. 16 February 2021

Sepsis induces interleukin 6, gp130/JAK2/STAT3, and muscle wasting.
Zanders, L., Kny, M., Hahn, A., Schmidt, S., Wundersitz, S., Todiras, M., Lahmann, I., Bandyopadhyay, A., Wollersheim, T., Kaderali, L., Luft, F.C., Birchmeier, C., Weber-Carstens, S. and Fielitz, J.
Journal of Cachexia Sarcopenia and Muscle 13 (1): 713-727. February 2021

2020

Fructose 1,6-bisphosphate sensing by pyruvate kinase isozymes M2 (PKM2) controls MyoD stability and myogenic differentiation.
Kim, M., Zhang, Y. and Birchmeier, C.
bioRxiv : 2020.12.22.424062. 22 December 2020

Single-nucleus transcriptomics reveals functional compartmentalization in syncytial skeletal muscle cells.
Kim, M., Franke, V., Brandt, B., Lowenstein, E.D., Schöwel, V., Spuler, S., Akalin, A. and Birchmeier, C.
Nature Communications 11 : 6375. 11 December 2020

Olig3 acts as a master regulator of cerebellar development.
Lowenstein, E.D., Rusanova, A., Stelzer, J., Hernaiz-Llorens, M., Schroer, A.E., Epifanova, E., Bladt, F., Isik, E.G., Jia, S., Tarabykin, V. and Hernandez-Miranda, L.R.
bioRxiv : 2020.10.10.334615. 10 October 2020

SIX1 and SIX4 homeoproteins regulate PAX7+ progenitor cell properties during fetal epaxial myogenesis.
Wurmser, M., Chaverot, N., Madani, R., Sakai, H., Negroni, E., Demignon, J., Saint-Pierre, B., Mouly, V., Amthor, H., Tapscott, S., Birchmeier, C., Tajbakhsh, S., Le Grand, F., Sotiropoulos, A. and Maire, P.
Development 147 (19): dev185975. 9 October 2020

EHD2-mediated restriction of caveolar dynamics regulates cellular fatty acid uptake.
Matthaeus, C., Lahmann, I., Kunz, S., Jonas, W., Melo, A.A., Lehmann, M., Larsson, E., Lundmark, R., Kern, M., Blüher, M., Olschowski, H., Kompa, J., Brügger, B., Müller, D.N., Haucke, V., Schürmann, A., Birchmeier, C. and Daumke, O.
Proceedings of the National Academy of Sciences of the United States of America 117 (13): 7471-7481. 31 March 2020

Self-organizing 3D human trunk neuromuscular organoids.
Faustino Martins, J.M., Fischer, C., Urzi, A., Vidal, R., Kunz, S., Ruffault, P.L., Kabuss, L., Hube, I., Gazzerro, E., Birchmeier, C., Spuler, S., Sauer, S. and Gouti, M.
Cell Stem Cell 26 (2): 172-186. 6 February 2020

Nonclinical data supporting orphan medicinal product designations in the area of rare infectious diseases.
Sheean, M.E., Malikova, E., Duarte, D., Capovilla, G., Fregonese, L., Hofer, M., Magrelli, A., Mariz, S., Mendez-Hermida, F., Nistico, R., Leest, T., Sipsas, N.V., Tsigkos, S., Vitezic, D., Larsson, K., Sepodes, B. and Stoyanova-Beninska, V.
Drug Discovery Today 25 (2): 274-291. February 2020

2019

Human muscle-derived CLEC14A-positive cells regenerate muscle independent of PAX7.
Marg, A., Escobar Fernandez, H., Karaiskos, N., Grunwald, S.A., Metzler, E., Kieshauer, J., Sauer, S., Pasemann, D., Malfatti, E., Mompoint, D., Quijano-Roy, S., Boltengagen, A., Schneider, J., Schülke, M., Kunz, S., Carlier, R., Birchmeier, C., Amthor, H., Spuler, A., Kocks, C., Rajewsky, N. and Spuler, S.
Nature Communications 10 (1): 5776. 18 December 2019

Context-specific regulation of cell survival by a miRNA-controlled BIM rheostat.
Labi, V., Peng, S., Klironomos, F., Munschauer, M., Kastelic, N., Chakraborty, T., Schoeler, K., Derudder, E., Martella, M., Mastrobuoni, G., Hernandez-Miranda, L.R., Lahmann, I., Kocks, C., Birchmeier, C., Kempa, S., Quintanilla-Martinez de Fend, L., Landthaler, M., Rajewsky, N. and Rajewsky, K.
Genes & Development 33 : 23-24. 7 November 2019

β-secretase BACE1 is required for normal cochlear function.
Dierich, M., Hartmann, S., Dietrich, N., Moeser, P., Brede, F., Johnson Chacko, L., Tziridis, K., Schilling, A., Krauss, P., Hessler, S., Karch, S., Schrott-Fischer, A., Blumer, M., Birchmeier, C., Oliver, D., Moser, T., Schulze, H., Alzheimer, C., Leitner, M.G. and Huth, T.
Journal of Neuroscience 39 (45): 9013-9027. 6 November 2019

eNOS-NO-induced small blood vessel relaxation requires EHD2-dependent caveolae stabilization.
Matthaeus, C., Lian, X., Kunz, S., Lehmann, M., Zhong, C., Bernert, C., Lahmann, I., Müller, D.N., Gollasch, M. and Daumke, O.
PLoS ONE 14 (10): e0223620. 10 October 2019

Ribosome profiling of selenoproteins in vivo reveals consequences of pathogenic Secisbp2 missense mutations.
Zhao, W., Bohleber, S., Schmidt, H., Seeher, S., Howard, M.T., Braun, D., Arndt, S., Reuter, U., Wende, H., Birchmeier, C., Fradejas-Villar, N. and Schweizer, U.
Journal of Biological Chemistry 294 (39): 14185-14200. 27 September 2019

Teashirt 1 (Tshz1) is essential for the development, survival and function of hypoglossal and phrenic motor neurons in mouse.
Chaimowicz, C., Ruffault, P.L., Chéret, C., Woehler, A., Zampieri, N., Fortin, G., Garratt, A.N. and Birchmeier, C.
Development 146 (17): dev174045. 6 September 2019

Defining orphan conditions in the context of the European orphan regulation: challenges and evolution.
O'Connor, D.J., Sheean, M.E., Hofer, M.P., Tsigkos, S., Mariz, S., Fregonese, L., Larsson, K., Hivert, V., Westermark, K., Naumann-Winter, F., Stoyanova-Beninska, V., Barišić, I., Capovilla, G., Magrelli, A. and Sepodes, B.
Nature Reviews Drug Discovery 18 (7): 479-480. July 2019

Oscillations of MyoD and Hes1 proteins regulate the maintenance of activated muscle stem cells.
Lahmann, I., Bröhl, D., Zyrianova, T., Isomura, A., Czajkowski, M.T., Kapoor, V., Griger, J., Ruffault, P.L., Mademtzoglou, D., Zammit, P.S., Wunderlich, T., Spuler, S., Kühn, R., Preibisch, S., Wolf, J., Kageyama, R. and Birchmeier, C.
Genes & Development 33 (9-10): 524-535. 1 May 2019

HDAC4 mutations cause diabetes and induce β-cell FoxO1 nuclear exclusion.
Gong, M., Yu, Y., Liang, L., Vuralli, D., Froehler, S., Kuehnen, P., Du Bois, P., Zhang, J., Cao, A., Liu, Y., Hussain, K., Fielitz, J., Jia, S., Chen, W. and Raile, K.
Molecular Genetics & Genomic Medicine 7 (5): e602. May 2019

Alternative 3' UTRs direct localization of functionally diverse protein isoforms in neuronal compartments.
Ciolli Mattioli, C., Rom, A., Franke, V., Imami, K., Arrey, G., Terne, M., Woehler, A., Akalin, A., Ulitsky, I. and Chekulaeva, M.
Nucleic Acids Research 47 (5): 2560-2573. 18 March 2019

Diversity in the lab makes me a better scientist.
Lowenstein, E.
Scientific American 320 (1): 8. January 2019

240th ENMC workshop: The involvement of skeletal muscle stem cells in the pathology of muscular dystrophies 25–27 January 2019, Hoofddorp, The Netherlands.
Morgan, J., Butler-Browne, G., Muntoni, F. and Patel, K.
Neuromuscular Disorders 29 (9): 704-715. 2019

2018

Mutation in LBX1/Lbx1 precludes transcription factor cooperativity and causes congenital hypoventilation in humans and mice.
Hernandez-Miranda, L.R., Ibrahim, D.M., Ruffault, P.L., Larrosa, M., Balueva, K., Müller, T., de Weerd, W., Stolte-Dijkstra, I., Hostra, R.M.W., Brunet, J.F., Fortin, G., Mundlos, S. and Birchmeier, C.
Proceedings of the National Academy of Sciences of the United States of America 115 (51): 13021-13026. 18 December 2018

Haploinsufficiency of Insm1 impairs postnatal baseline β-cell mass.
Tao, W., Zhang, Y., Ma, L., Deng, C., Duan, H., Liang, X., Liao, R., Lin, S., Nie, T., Chen, W., Wang, C., Birchmeier, C. and Jia, S.
Diabetes 67 (12): 2615-2625. December 2018

Mutations in disordered regions can cause disease by creating dileucine motifs.
Meyer, K., Kirchner, M., Uyar, B., Cheng, J.Y., Russo, G., Hernandez-Miranda, L.R., Szymborska, A., Zauber, H., Rudolph, I.M., Willnow, T.E., Akalin, A., Haucke, V., Gerhardt, H., Birchmeier, C., Kühn, R., Krauss, M., Diecke, S., Pascual, J.M. and Selbach, M.
Cell 175 (1): 239-253. 20 September 2018

Neuregulin 3 promotes excitatory synapse formation on hippocampal interneurons.
Müller, T., Braud, S., Jüttner, R., Voigt, B.C., Paulick, K., Sheean, M.E., Klisch, C., Gueneykaya, D., Rathjen, F.G., Geiger, J.R.P., Poulet, J.F.A. and Birchmeier, C.
EMBO Journal 37 (17): e98858. 3 September 2018

Maf links Neuregulin1 signaling to cholesterol synthesis in myelinating Schwann cells.
Kim, M., Wende, H., Walcher, J., Kühnemund, J., Cheret, C., Kempa, S., McShane, E., Selbach, M., Lewin, G.R. and Birchmeier, C.
Genes & Development 32 (9-10): 645-657. 10 May 2018

Predominant patterns of splicing evolution on human, chimpanzee, and macaque evolutionary lineages.
Xiong, J., Xi, J., Ditsiou, A., Gao, Y., Sun, J., Lowenstein, E.D., Huang, S. and Khaitovich, P.
Human Molecular Genetics 27 (8): 1474-1485. 15 April 2018

Establishing rarity in the context of orphan medicinal product designation in the European Union.
Tsigkos, S., Hoffer, M.P., Sheean, M.E., Mariz, S., Larsson, K., Naumann-Winter, F., Fregonese, L. and Sepodes, B.
Drug Discovery Today 23 (3): 681-686. March 2018

Sustained MAPK/ERK activation in adult Schwann cells impairs nerve repair.
Cervellini, I., Galino, J., Zhu, N., Allen, S., Birchmeier, C. and Bennett, D.L.
Journal of Neuroscience 38 (3): 679-690. 17 January 2018

Nonclinical data supporting orphan medicinal product designations: lessons from rare neurological conditions.
Sheean, M.E., Stoyanova-Beninska, V., Capovilla, G., Duarte, D., Hofer, M.P., Hoffmann, M., Magrelli, A., Mariz, S., Tsigkos, S., Shaili, E., Polsinelli, B., Ricciardi, M., Bonelli, M., Balabanov, P., Larsson, K. and Sepodes, B.
Drug Discovery Today 23 (1): 26-48. January 2018

2017

The dorsal spinal cord and hindbrain: from developmental mechanisms to functional circuits.
Hernandez-Miranda, L.R., Müller, T. and Birchmeier, C.
Developmental Biology 432 (1): 34-42. 1 December 2017

Dual origin of enteric neurons in vagal Schwann cell precursors and the sympathetic neural crest.
Espinosa-Medina, I., Jevans, B., Boismoreau, F., Chettouh, Z., Enomoto, H., Müller, T., Birchmeier, C., Burns, Alan J and Brunet, J.F.
Proceedings of the National Academy of Sciences of the United States of America 114 (45): 11980-11985. 7 November 2017

Mutations in MYO1H cause a recessive form of central hypoventilation with autonomic dysfunction.
Spielmann, M., Hernandez-Miranda, L.R., Ceccherini, I., Weese-Mayer, D.E., Kragesteen, B.K., Harabula, I., Krawitz, P., Birchmeier, C., Leonard, N. and Mundlos, S.
Journal of Medical Genetics 54 (11): 754-761. November 2017

Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function.
Piwecka, M., Glažar, P., Hernandez-Miranda, L.R., Memczak, S., Wolf, S.A., Rybak-Wolf, A., Filipchyk, A., Klironomos, F., Cerda Jara, C.A., Fenske, P., Trimbuch, T., Zywitza, V., Plass, M., Schreyer, L., Ayoub, S., Kocks, C., Kühn, R., Rosenmund, C., Birchmeier, C. and Rajewsky, N.
Science 357 (6357): eaam8526. 22 September 2017

RNA localization is a key determinant of neurite-enriched proteome.
Zappulo, A., van den Bruck, D., Ciolli Mattioli, C., Franke, V., Imami, K., McShane, E., Moreno-Estelles, M., Calviello, L., Filipchyk, A., Peguero-Sanchez, E., Müller, T., Woehler, A., Birchmeier, C., Merino, E., Rajewsky, N., Ohler, U., Mazzoni, E.O., Selbach, M., Akalin, A. and Chekulaeva, M.
Nature Communications 8 (1): 583. 19 September 2017

BMP signaling regulates satellite cell dependent postnatal muscle growth.
Stantzou, A., Schirwis, E., Swist, S., Alonso-Martin, S., Polydorou, I., Zarrouki, F., Mouisel, E., Beley, C., Julien, A., Le Grand, F., Garcia, L., Colnot, C., Birchmeier, C., Braun, T., Schuelke, M., Relaix, F. and Amthor, H.
Development 144 (15): 2737-2747. 1 August 2017

Genetic identification of a hindbrain nucleus essential for innate vocalization.
Hernandez-Miranda, L.R., Ruffault, P.L., Bouvier, J.C., Murray, A.J., Morin-Surun, M.P., Zampieri, N., Cholewa-Waclaw, J.B., Ey, E., Brunet, J.F., Champagnat, J., Fortin, G. and Birchmeier, C.
Proceedings of the National Academy of Sciences of the United States of America 114 (30): 8095-8100. 25 July 2017

Cell fixation and preservation for droplet-based single-cell transcriptomics.
Alles, J., Karaiskos, N., Praktiknjo, S.D., Grosswendt, S., Wahle, P., Ruffault, P.L., Ayoub, S., Schreyer, L., Boltengagen, A., Birchmeier, C., Zinzen, R., Kocks, C. and Rajewsky, N.
BMC Biology 15 (1): 44. 19 May 2017

Loss of Ptpn11 (Shp2) drives satellite cells into quiescence.
Griger, J., Schneider, R., Lahmann, I., Schöwel, V., Keller, C., Spuler, S., Nazare, M. and Birchmeier, C.
eLife 6 : e21552. 2 May 2017

Homozygous ARHGEF2 mutation causes intellectual disability and midbrain-hindbrain malformation.
Ravindran, E., Hu, H., Yuzwa, S.A., Hernandez-Miranda, L.R., Kraemer, N., Ninnemann, O., Musante, L., Boltshauser, E., Schindler, D., Hübner, A., Reinecker, H.-C., Ropers, H.-H., Birchmeier, C., Miller, F.D., Wienker, T.F., Hübner, C. and Kaindl, A.M.
PLoS Genetics 13 (4): e1006746. 28 April 2017

Neuregulin-1 mutant mice indicate motor and sensory deficits, indeed few references for schizophrenia endophenotype model.
Schneider, S., Götz, K., Birchmeier, C., Schwegler, H. and Roskoden, T.
Behavioural Brain Research 322 (Pt A): 177-185. 30 March 2017

Touch receptor-derived sensory information alleviates acute pain signaling and fine-tunes nociceptive reflex coordination.
Arcourt, A., Gorham, L., Dhandapani, R., Prato, V., Taberner, F.J., Wende, H., Gangadharan, V., Birchmeier, C., Heppenstall, P.A. and Lechner, S.G.
Neuron 93 (1): 179-193. 4 January 2017

2016

Muscle contraction is required to maintain the pool of muscle progenitors via YAP and NOTCH during fetal myogenesis.
Esteves de Lima, J., Bonnin, M.A., Birchmeier, C. and Duprez, D.
eLife 5 : e15593. 24 August 2016

Neuregulin-1 controls an endogenous repair mechanism after spinal cord injury.
Bartus, K., Galino, J., James, N.D., Hernandez-Miranda, L.R., Dawes, J.M., Fricker, F.R., Garratt, A.N., McMahon, S.B., Ramer, M.S., Birchmeier, C., Bennett, D.L.H. and Bradbury, E.J.
Brain 139 (Pt 5): 1394-1416. May 2016

Neuregulin/ErbB signaling in developmental myelin formation and nerve repair.
Birchmeier, C. and Bennett, D.L.H.
Current Topics in Developmental Biology 116 : 45-64. 2016

2015

Insm1 controls the differentiation of pulmonary neuroendocrine cells by repressing Hes1.
Jia, S., Wildner, H. and Birchmeier, C.
Developmental Biology 408 (1): 90-98. 1 December 2015

Bcl11a (Ctip1) controls migration of cortical projection neurons through regulation of Sema3c.
Wiegreffe, C., Simon, R., Peschkes, K., Kling, C., Strehle, M., Cheng, J., Srivatsa, S., Liu, P., Jenkins, N.A., Copeland, N.G., Tarabykin, V. and Britsch, S.
Neuron 87 (2): 311-325. 15 July 2015

CO(2) in the spotlight.
Hernandez-Miranda, L.R. and Birchmeier, C.
eLife 4 : e08086. 13 May 2015

Insm1 cooperates with Neurod1 and Foxa2 to maintain mature pancreatic β-cell function.
Jia, S., Ivanov, A., Blasevic, D., Müller, T., Purfürst, B., Sun, W., Chen, W., Poy, M.N., Rajewsky, N. and Birchmeier, C.
EMBO Journal 34 (10): 1417-1433. 12 May 2015

Quantitative proteomics reveals dynamic interaction of c-Jun N-terminal kinase (JNK) with RNA transport granule proteins splicing factor proline- and glutamine-rich (Sfpq) and non-POU domain-containing octamer-binding protein (Nono) during neuronal differentiation.
Sury, M.D., McShane, E., Hernandez-Miranda, L.R., Birchmeier, C. and Selbach, M.
Molecular & Cellular Proteomics 14 (1): 50-65. 1 January 2015

2014

Divergent and conserved roles of Dll1 signaling in development of craniofacial and trunk muscle.
Czajkowski, M.T., Rassek, C., Lenhard, D., Bröhl, D. and Birchmeier, C.
Developmental Biology 395 (2): 307-3016. 15 November 2014

Neuregulin-3 in the mouse medial prefrontal cortex regulates impulsive action.
Loos, M., Mueller, T., Gouwenberg, Y., Wijnands, R., van der Loo, R.J., Birchmeier, C., Smit, A.B. and Spijker, S.
Biological Psychiatry 76 (8): 648-655. 15 October 2014

Human satellite cells have regenerative capacity and are genetically manipulable.
Marg, A., Escobar, H., Gloy, S., Kufeld, M., Zacher, J., Spuler, A., Birchmeier, C., Izsvák, Z. and Spuler, S.
Journal of Clinical Investigation 124 (10): 4257-4265. 1 October 2014

Recessive mutations in PCBD1 cause a new type of early-onset diabetes.
Simaite, D., Kofent, J., Gong, M., Rüschendorf, F., Jia, S., Arn, P., Bentler, K., Ellaway, C., Kühnen, P., Hoffmann, G.F., Blau, N., Spagnoli, F.M., Hübner, N. and Raile, K.
Diabetes 63 (10): 3557-3564. October 2014

Parasympathetic neurons originate from nerve-associated peripheral glial progenitors.
Dyachuk, V., Furlan, A., Shahidi, M.K., Giovenco, M., Kaukua, N., Konstantinidou, C., Pachnis, V., Memic, F., Marklund, U., Müller, T., Birchmeier, C., Fried, K., Ernfors, P. and Adameyko, I.
Science 345 (6192): 82-87. 4 July 2014

Antagonistic regulation of p57(kip2) by Hes/Hey downstream of Notch signaling and muscle regulatory factors regulates skeletal muscle growth arrest.
Zalc, A., Hayashi, S., Auradé, F., Bröhl, D., Chang, T., Mademtzoglou, D., Mourikis, P., Yao, Z., Cao, Y., Birchmeier, C. and Relaix, F.
Development 141 (14): 2780-2790. July 2014

TSHZ1-dependent gene regulation is essential for olfactory bulb development and olfaction.
Ragancokova, D., Rocca, E., Oonk, A.M.M., Schulz, H., Rohde, E., Bednarsch, J., Feenstra, I., Pennings, R.J.E., Wende, H. and Garratt, A.N.
Journal of Clinical Investigation 124 (3): 1214-1227. 3 March 2014

Activation of MAPK overrides the termination of myelin growth and replaces Nrg1/ErbB3 signals during Schwann cell development and myelination.
Sheean, M.E., McShane, E., Cheret, C., Walcher, J., Müller, T., Wulf-Goldenberg, A., Hoelper, S., Garratt, A.N., Krüger, M., Rajewsky, K., Meijer, D., Birchmeier, W., Lewin, G.R., Selbach, M. and Birchmeier, C.
Genes & Development 28 (3): 290-303. 1 February 2014

2013

Insm1 controls development of pituitary endocrine cells and requires a SNAG domain for function and for recruitment of histone-modifying factors.
Welcker, J.E., Hernandez-Miranda, L.R., Paul, F.E., Jia, S., Ivanov, A., Selbach, M. and Birchmeier, C.
Development 140 (24): 4947-4958. December 2013

Wnt/Rspondin/β-catenin signals control axonal sorting and lineage progression in Schwann cell development.
Grigoryan, T., Stein, S., Qi, J., Wende, H., Garratt, A.N., Nave, K.A., Birchmeier, C. and Birchmeier, W.
Proceedings of the National Academy of Sciences of the United States of America 110 (45): 18174-18179. 5 November 2013

BMP signaling controls muscle mass.
Sartori, R., Schirwis, E., Blaauw, B., Bortolanza, S., Zhao, J., Enzo, E., Stantzou, A., Mouisel, E., Toniolo, L., Ferry, A., Stricker, S., Goldberg, A.L., Dupont, S., Piccolo, S., Amthor, H. and Sandri, M.
Nature Genetics 45 (11): 1309-1318. November 2013

Ontogeny of excitatory spinal neurons processing distinct somatic sensory modalities.
Xu, Y., Lopes, C., Wende, H., Guo, Z., Cheng, L., Birchmeier, C. and Ma, Q.
Journal of Neuroscience 33 (37): 14738-14748. 11 September 2013

Inactivation of ceramide synthase 6 in mice results in an altered sphingolipid metabolism and behavioral abnormalities.
Ebel, P., Vom Dorp, K., Petrasch-Parwez, E., Zlomuzica, A., Kinugawa, K., Mariani, J., Minich, D., Ginkel, C., Welcker, J., Degen, J., Eckhardt, M., Dere, E., Doermann, P. and Willecke, K.
Journal of Biological Chemistry 288 (29): 21433-21447. 19 July 2013

Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles.
Cheret, C., Willem, M., Fricker, F.R., Wende, H., Wulf-Goldenberg, A., Tahirovic, S., Nave, K.A., Saftig, P., Haass, C., Garratt, A.N., Bennett, D.L. and Birchmeier, C.
EMBO Journal 32 (14): 2015-2028. 17 July 2013

Axonal neuregulin 1 is a rate limiting but not essential factor for nerve remyelination.
Fricker, F.R., Antunes-Martins, A., Galino, J., Paramsothy, R., La Russa, F., Perkins, J., Goldberg, R., Brelstaff, J., Zhu, N., McMahon, S.B., Orengo, C., Garratt, A.N., Birchmeier, C. and Bennett, D.L.
Brain 136 (Pt 7): 2279-2297. July 2013

Genome-wide expression analysis of ptf1a- and ascl1-deficient mice reveals new markers for distinct dorsal horn interneuron populations contributing to nociceptive reflex plasticity.
Wildner, H., Das Gupta, R., Bröhl, D., Heppenstall, P.A., Zeilhofer, H.U. and Birchmeier, C.
Journal of Neuroscience 33 (17): 7299-7307. 24 April 2013

Therapeutic potential of N-acetyl-glucagon-like peptide-1 in primary motor neuron cultures derived from non-transgenic and SOD1-G93A ALS mice.
Sun, H., Knippenberg, S., Thau, N., Ragancokova, D., Koerner, S., Huang, D., Dengler, R., Doehler, K. and Petri, S.
Cellular and Molecular Neurobiology 33 (3): 347-357. April 2013

2012

The transcription factor c-Maf in sensory neuron development.
Wende, H., Lechner, S.G. and Birchmeier, C.
Transcription 3 (6): 285-289. November 2012

A validated regulatory network for Th17 cell specification.
Ciofani, M., Madar, A., Galan, C., Sellars, M., Mace, K., Pauli, F., Agarwal, A., Huang, W., Parkurst, C.N., Muratet, M., Newberry, K.M., Meadows, S., Greenfield, A., Yang, Y., Jain, P., Kirigin, F.K., Birchmeier, C., Wagner, E.F., Murphy, K.M., Myers, R.M., Bonneau, R. and Littman, D.R.
Cell 151 (2): 289-303. 12 October 2012

Colonization of the satellite cell niche by skeletal muscle progenitor cells depends on notch signals.
Broehl, D., Vasyutina, E., Czajkowski, M.T., Griger, J., Rassek, C., Rahn, H.P., Purfürst, B., Wende, H. and Birchmeier, C.
Developmental Cell 23 (3): 469-481. 11 September 2012

The HGF receptor/Met tyrosine kinase is a key regulator of dendritic cell migration in skin immunity.
Baek, J.H., Birchmeier, C., Zenke, M. and Hieronymus, T.
Journal of Immunology 189 (4): 1699-1707. 15 August 2012

Nuclear movement during myotube formation is microtubule and dynein dependent and is regulated by Cdc42, Par6 and Par3.
Cadot, B., Gache, V., Vasyutina, E., Falcone, S., Birchmeier, C. and Gomes, E.R.
EMBO Reports 13 (8): 741-749. 1 August 2012

Uncoupling of PI3K from ErbB3 impairs mammary gland development but does not impact on ErbB2-induced mammary tumorigenesis.
Lahlou, H., Mueller, T., Sanguin-Gendreau, V., Birchmeier, C. and Muller, W.J.
Cancer Research 72 (12): 3080-3090. 15 June 2012

A dual function of Bcl11b/Ctip2 in hippocampal neurogenesis.
Simon, R., Brylka, H., Schwegler, H., Venkataramanappa, S., Andratschke, J., Wiegreffe, C., Liu, P., Fuchs, E., Jenkins, N.A., Copeland, N.G., Birchmeier, C. and Britsch, S.
EMBO Journal 31 (13): 2922-2936. 15 May 2012

Bcl11a is required for neuronal morphogenesis and sensory circuit formation in dorsal spinal cord development.
John, A., Brylka, H., Wiegreffe, C., Simon, R., Liu, P., Juettner, R., Crenshaw, E.B., Luyten, F.P., Jenkins, N.A., Copeland, N.G., Birchmeier, C. and Britsch, S.
Development 139 (10): 1831-1841. 15 May 2012

The transcription factor c-Maf controls touch receptor development and function.
Wende, H., Lechner, S.G., Cheret, C., Bourane, S., Kolanczyk, M.E., Pattyn, A., Reuter, K., Munier, F.L., Carroll, P., Lewin, G.R. and Birchmeier, C.
Science 335 (6074): 1373-1376. 16 March 2012

BACE1 dependent neuregulin processing: review.
Fleck, D., Garratt, A.N., Haass, C. and Willem, M.
Current Alzheimer Research 9 (2): 178-183. February 2012

Targeting MET in cancer: rationale and progress.
Gherardi, E., Birchmeier, W., Birchmeier, C. and Woude, G.V.
Nature Reviews Cancer 12 (2): 89-103. February 2012

Sox2 and Mitf cross-regulatory interactions consolidate progenitor and melanocyte lineages in the cranial neural crest.
Adameyko, I., Lallemend, F., Furlan, A., Zinin, N., Aranda, S., Kitambi, S.S., Blanchart, A., Favaro, R., Nicolis, S., Luebke, M., Mueller, T., Birchmeier, C., Suter, U., Zaitoun, I., Takahashi, Y. and Ernfors, P.
Development 139 (2): 397-410. 15 January 2012

2011

Homeoprotein Phox2b commands a somatic-to-visceral switch in cranial sensory pathways.
D'Autreaux, F., Coppola, E., Hirsch, M.R., Birchmeier, C. and Brunet, J.F.
Proceedings of the National Academy of Sciences of the United States of America 108 (50): 20018-20023. 13 December 2011

Neural crest cell lineage restricts skeletal muscle progenitor cell differentiation through Neuregulin1-ErbB3 signaling.
Van Ho, A.T., Hayashi, S., Broehl, D., Aurade, F., Rattenbach, R. and Relaix, F.
Developmental Cell 21 (2): 273-287. 16 August 2011

Axonally derived neuregulin-1 is required for remyelination and regeneration after nerve injury in adulthood.
Fricker, F.R., Lago, N., Balarajah, S., Tsantoulas, C., Tanna, S., Zhu, N., Fageiry, S.K., Jenkins, M., Garratt, A.N., Birchmeier, C. and Bennett, D.L.
Journal of Neuroscience 31 (9): 3225-3233. 2 March 2011

Preface.
Birchmeier, C.
Current Topics in Developmental Biology 97 : xi-xii. 2011

2010

Nrg1/ErbB signaling networks in Schwann cell development and myelination.
Newbern, J. and Birchmeier, C.
Seminars in Cell & Developmental Biology 21 (9): 922-988. December 2010

Development and more.
Birchmeier, C.
Seminars in Cell & Developmental Biology 21 (8): 812-813. October 2010

Neuregulin 1 sustains the gene regulatory network in both trabecular and nontrabecular myocardium.
Lai, D., Forrai, A., Liu, X., Wolstein, O., Michalicek, J., Ahmed, I., Garratt, A.N., Birchmeier, C., Zhou, M., Hartley, L., Robb, L., Feneley, M.P., Fatkin, D. and Harvey, R.P.
Circulation Research 107 (6): 715-727. 17 September 2010

The tyrosine phosphatase Shp2 in development and cancer.
Grossmann, K.S., Rosario, M., Birchmeier, C. and Birchmeier, W.
Advances in Cancer Research 106 : 53-89. 2010

2009

A fresh breeze from the ivory tower.
Birchmeier, C.
Current Opinion in Cell Biology 21 (6): 725-726. December 2009

Defective respiratory rhythmogenesis and loss of central chemosensitivity in Phox2b mutants targeting retrotrapezoid nucleus neurons.
Dubreuil, V., Thoby-Brisson, M., Rallu, M., Persson, K., Pattyn, A., Birchmeier, C., Brunet, J.F., Fortin, G. and Goridis, C.
Journal of Neuroscience 29 (47): 14836-14846. 25 November 2009

Schwann cell precursors from nerve innervation are a cellular origin of melanocytes in skin.
Adameyko, I., Lallemend, F., Aquino, J.B., Pereira, J.A., Topilko, P., Mueller, T., Fritz, N., Beljajeva, A., Mochii, M., Liste, I., Usoskin, D., Suter, U., Birchmeier, C. and Ernfors, P.
Cell 139 (2): 366-379. 16 October 2009

The tyrosine phosphatase Shp2 (PTPN11) directs neuregulin-1/ErbB signaling throughout schwann cell development.
Grossmann, K.S., Wende, H., Paul, F.E., Cheret, C., Garratt, A.N., Zurborg, S., Feinberg, K., Besser, D., Schulz, H., Peles, E., Selbach, M., Birchmeier, W. and Birchmeier, C.
Proceedings of the National Academy of Sciences of the United States of America 106 (39): 16704-16709. 29 September 2009

Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling.
Trimbuch, T., Beed, P., Vogt, J., Schuchmann, S., Maier, N., Kintscher, M., Breustedt, J., Schuelke, M., Streu, N., Kieselmann, O., Brunk, I., Laube, G., Strauss, U., Battefeld, A., Wende, H., Birchmeier, C., Wiese, S., Sendtner, M., Kawabe, H., Kishimoto-Suga, M., Brose, N., Baumgart, J., Geist, B., Aoki, J., Savaskan, N.E., Braeuer, A.U., Chun, J., Ninnemann, O., Schmitz, D. and Nitsch, R.
Cell 138 (6): 1222-12235. 18 September 2009

Insm1 (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the vertebrate hindbrain.
Jacob, J., Storm, R., Castro, D.S., Milton, C., Pla, P., Guillemot, F., Birchmeier, C. and Briscoe, J.
Development 136 (14): 2477-2485. July 2009

c-Met confers protection against chronic liver tissue damage and fibrosis progression after bile-duct-ligation in mice.
Giebeler, A., Boekschoten, M.V., Klein, C., Borowiak, M., Birchmeier, C., Gassler, N., Wasmuth, H.E., Mueller, M., Trautwein, C. and Streetz, K.L.
Gastroenterology 137 (1): 297-308. July 2009

Sensory axon-derived neuregulin-1 is required for axoglial signaling and normal sensory function but not for long-term axon maintenance.
Fricker, F.R., Zhu, N., Tsantoulas, C., Abrahamsen, B., Nassar, M.A., Thakur, M., Garratt, A.N., Birchmeier, C., McMahon, S.B., Wood, J.N. and Bennett, D.L.
Journal of Neuroscience 29 (24): 7667-7678. 17 June 2009

The small G-proteins Rac1 and Cdc42 are essential for myoblast fusion in the mouse.
Vasyutina, E., Martarelli, B., Brakebusch, C., Wende, H. and Birchmeier, C.
Proceedings of the National Academy of Sciences of the United States of America 106 (22): 8935-8940. 2 June 2009

Hepatocarcinogenesis in mice with a conditional knockout of the hepatocyte growth factor receptor c-Met.
Marx-Stoelting, P., Borowiak, M., Knorpp, T., Birchmeier, C., Buchmann, A. and Schwarz, M.
International Journal of Cancer 124 (8): 1767-1772. 15 April 2009

The effects of alpha-secretase ADAM10 on the proteolysis of neuregulin-1.
Freese, C., Garratt, A.N., Fahrenholz, F. and Endres, K.
FEBS Journal 276 (6): 1568-1580. March 2009

ErbB receptors and the development of the nervous system.
Birchmeier, C.
Experimental Cell Research 315 (4): 611-618. 15 February 2009

The bHLH transcription factor Olig3 marks the dorsal neuroepithelium of the hindbrain and is essential for the development of brainstem nuclei.
Storm, R., Cholewa-Waclaw, J., Reuter, K., Broehl, D., Sieber, M., Treier, M., Mueller, T. and Birchmeier, C.
Development 136 (2): 295-305. January 2009

2008

Neuregulin-1, a key axonal signal that drives Schwann cell growth and differentiation.
Birchmeier, C. and Nave, K.A.
Glia 56 (14): 1491-1497. 1 November 2008

A transcriptional network coordinately determines transmitter and peptidergic fate in the dorsal spinal cord.
Broehl, D., Strehle, M., Wende, H., Hori, K., Bormuth, I., Nave, K.A., Mueller, T. and Birchmeier, C.
Developmental Biology 322 (2): 381-393. 15 October 2008

Insulinoma-associated 1 has a panneurogenic role and promotes the generation and expansion of Basal progenitors in the developing mouse neocortex.
Farkas, L.M., Haffner, C., Giger, T., Khaitovich, P., Nowick, K., Birchmeier, C., Paeaebo, S. and Huttner, W.B.
Neuron 60 (1): 40-55. 9 October 2008

Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4.
Caubit, X., Lye, C.M., Martin, E., Core, N., Long, D.A., Vola, C., Jenkins, D., Garratt, A.N., Skaer, H., Woolf, A.S. and Fasano, L.
Development 135 (19): 3301-3310. October 2008

Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system.
Brinkmann, B.G., Agarwal, A., Sereda, M.W., Garratt, A.N., Mueller, T., Wende, H., Stassart, R.M., Nawaz, S., Humml, C., Velanac, V., Radyushkin, K., Goebbels, S., Fischer, T.M., Franklin, R.J., Lai, C., Ehrenreich, H., Birchmeier, C., Schwab, M.H. and Nave, K.A.
Neuron 59 (4): 581-595. 28 August 2008

Insm1 (IA-1) is a crucial component of the transcriptional network that controls differentiation of the sympatho-adrenal lineage.
Wildner, H., Gierl, M.S., Strehle, M., Pla, P. and Birchmeier, C.
Development 135 (3): 473-81. February 2008

A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling.
Hori, K., Cholewa-Waclaw, J., Nakada, Y., Glasgow, S.M., Masui, T., Henke, R.M., Wildner, H., Martarelli, B., Beres, T.M., Epstein, J.A., Magnuson, M.A., Macdonald, R.J., Birchmeier, C. and Johnson, J.E.
Genes & Development 22 (2): 166-178. 15 January 2008

2007

Nociceptive tuning by stem cell factor/c-Kit signaling.
Milenkovic, N., Frahm, C., Gassmann, M., Griffel, C., Erdmann, B., Birchmeier, C., Lewin, G.R. and Garratt, A.N.
Neuron 56 (5): 893-906. 6 December 2007

A mutation of keratin 18 within the coil 1A consensus motif causes widespread keratin aggregation but cell type-restricted lethality in mice.
Hesse, M., Grund, C., Herrmann, H., Broehl, D., Franz, T., Omary, M.B. and Magin, T.M.
Experimental Cell Research 313 (14): 3127-3140. 15 August 2007

Prolonged Sox4 expression in oligodendrocytes interferes with normal myelination in the central nervous system.
Potzner, M.R., Griffel, C., Luetjen-Drecoll, E., Boesl, M.R., Wegner, M. and Sock, E.
Molecular and Cellular Biology 27 (15): 5316-5326. August 2007

Notch function in myogenesis.
Vasyutina, E., Lenhard, D.C. and Birchmeier, C.
Cell Cycle 6 (12): 1451-1454. 15 June 2007

Lbx1 acts as a selector gene in the fate determination of somatosensory and viscerosensory relay neurons in the hindbrain.
Sieber, M.A., Storm, R., Martinez-de-la-Torre, M., Mueller, T., Wende, H., Reuter, K., Vasyutina, E. and Birchmeier, C.
Journal of Neuroscience 27 (18): 4902-4909. 2 May 2007

c-Met is essential for wound healing in the skin.
Chmielowiec, J., Borowiak, M., Morkel, M., Stradal, T., Munz, B., Werner, S., Wehland, J., Birchmeier, C. and Birchmeier, W.
Journal of Cell Biology 177 (1): 151-162. 9 April 2007

RBP-J (Rbpsuh) is essential to maintain muscle progenitor cells and to generate satellite cells.
Vasyutina, E., Lenhard, D.C., Wende, H., Erdmann, B., Epstein, J.A. and Birchmeier, C.
Proceedings of the National Academy of Sciences of the United States of America 104 (11): 4443-4448. 13 March 2007

Bmp and Wnt/beta-catenin signals control expression of the transcription factor Olig3 and the specification of spinal cord neurons.
Zechner, D., Muller, T., Wende, H., Walther, I., Taketo, M.M., Crenshaw, E.B., Treier, M., Birchmeier, W. and Birchmeier, C.
Developmental Biology 303 (1): 181-190. 1 March 2007

Notch signaling is essential for ventricular chamber development.
Grego-Bessa, J., Luna-Zurita, L., del Monte, G., Bolos, V., Melgar, P., Arandilla, A., Garratt, A.N., Zang, H., Mukouyama, Y.S., Chen, H., Shou, W., Ballestar, E., Esteller, M., Rojas, A., Perez-Pomares, J.M. and de la Pompa, J.L.
Developmental Cell 12 (3): 415-429. March 2007

Post-transcriptional regulation of the let-7 microRNA during neural cell specification.
Wulczyn, F.G., Smirnova, L., Rybak, A., Brandt, C., Kwidzinski, E., Ninnemann, O., Strehle, M., Seiler, A., Schumacher, S. and Nitsch, R.
FASEB Journal 21 (2): 415-426. February 2007

2006

The development of migrating muscle precursor cells.
Vasyutina, E. and Birchmeier, C.
Anatomy and Embryology 211 (Suppl.): S37-S41. December 2006

Control of peripheral nerve myelination by the β-secretase BACE1.
Willem, M., Garratt, A.N., Novak, B., Citron, M., Kaufmann, S., Rittger, A., Destrooper, B., Saftig, P., Birchmeier, C. and Haass, C.
Science 314 (5799): 664-666. 27 October 2006

The Zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic beta cells and intestinal endocrine cells.
Gierl, M.S., Karoulias, N., Wende, H., Strehle, M. and Birchmeier, C.
Genes & Development 20 (17): 2465-2478. 1 September 2006

"To erb-B or not to erb-B..." Neuregulin-1/ErbB signaling in heart development and function.
Garratt, A.N.
Journal of Molecular and Cellular Cardiology 41 (2): 215-218. August 2006

Die Funktion des Transkriptionsfaktors Olig3 in der Entwicklung des Hirnstamms [The function of the transcription factor Olig3 in the development of the hindbrain].
Reuter, K.
UNSPECIFIED thesis, UNSPECIFIED. 14 July 2006

dILA neurons in the dorsal spinal cord are the product of terminal and non-terminal asymmetric progenitor cell divisions, and require Mash1 for their development.
Wildner, H., Mueller, T., Cho, S.H., Broehl, D., Cepko, C.L., Guillemot, F. and Birchmeier, C.
Development 133 (11): 2105-2113. 1 June 2006

Tangential neuronal migration controls axon guidance: a role for neuregulin-1 in thalamocortical axon navigation.
Lopez-Bendito, G., Cautinat, A., Sanchez, J.A., Bielle, F., Flames, N., Garratt, A.N., Talmage, D.A., Role, L.W., Charnay, P., Marin, O. and Garel, S.
Cell 125 (1): 127-142. 7 April 2006

ErbB2 signaling in Schwann cells is mostly dispensable for maintenance of myelinated peripheral nerves and proliferation of adult Schwann cells after injury.
Atanasoski, S., Scherer, S.S., Sirkowski, E., Leone, D., Garratt, A.N., Birchmeier, C. and Suter, U.
Journal of Neuroscience 26 (7): 2124-2131. 15 February 2006

Neural development.
Mueller, T.
In: Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine ; Vol. 2. Springer, Berlin [u.a.], 1258-1266. ISBN 3-540-44244-8 2006

Transgenic and knock-out animals.
Britsch, S.
In: Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine ; Vol. 2. Springer, Berlin [u.a.], 1900-1903. ISBN 3-540-44244-8 2006

2005

The homeodomain transcription factor Gbx1 identifies a subpopulation of late-born GABAergic interneurons in the developing dorsal spinal cord.
John, A., Wildner, H. and Britsch, S.
Developmental Dynamics 234 (3): 767-771. 28 September 2005

CXCR4 and Gab1 cooperate to control the development of migrating muscle progenitor cells.
Vasyutina, E., Stebler, J., Brand-Saberi, B., Schulz, S., Raz, E. and Birchmeier, C.
Genes & Development 19 (18): 2187-2198. 15 September 2005

Dual functionality of the anti-beta1 integrin antibody, 12G10, exemplifies agonistic signalling from the ligand binding pocket of integrin adhesion receptors.
Humphries, J.D., Schofield, N.R., Mostafavi-Pour, Z., Green, L.J., Garratt, A.N., Mould, A.P. and Humphries, M.J.
Journal of Biological Chemistry 280 (11): 10234-10243. 18 March 2005

A role for E2F6 in the restriction of male-germ-cell-specific gene expression.
Pohlers, M., Truss, M., Frede, U., Scholz, A., Strehle, M., Kuban, R.J., Hoffmann, B., Morkel, M., Birchmeier, C. and Hagemeier, C.
Current Biology 15 (11): 1051-1057. 1 January 2005

The bHLH factor Olig3 coordinates the specification of dorsal neurons in the spinal cord.
Muller, T., Anlag, K., Wildner, H., Britsch, S., Treier, M. and Birchmeier, C.
Genes & Development 19 (6): 733-743. 1 January 2005

2004

Activating Met mutations produce unique tumor profiles in mice with selective duplication of the mutant allele.
Graveel, C., Su, Y., Koeman, J., Wang, L.M., Tessarollo, L., Fiscella, M., Birchmeier, C., Swiatek, P., Bronson, R. and Vande Woude, G.F.
Proceedings of the National Academy of Sciences of the United States of America 101 (49): 17198-17203. 7 December 2004

Short- and long-range attraction of cortical GABAergic interneurons by neuregulin-1.
Flames, N., Long, J.E., Garratt, A.N., Fischer, T.M., Gassmann, M., Birchmeier, C., Lai, C., Rubenstein, J.L. and Marin, O.
Neuron 44 (2): 251-261. 14 October 2004

Axonal neuregulin-1 regulates myelin sheath thickness.
Michailov, G.V., Sereda, M.W., Brinkmann, B.G., Fischer, T.M., Haug, B., Birchmeier, C., Role, L., Lai, C., Schwab, M.H. and Nave, K.A.
Science 304 (5671): 700-703. 30 April 2004

Met provides essential signals for liver regeneration.
Borowiak, M., Garratt, A.N., Wuestefeld, T., Strehle, M., Trautwein, C. and Birchmeier, C.
Proceedings of the National Academy of Sciences of the United States of America 101 (29): 10608-10613. 1 January 2004

2003

Met, metastasis, motility and more.
Birchmeier, C., Birchmeier, W., Gherardi, E. and Vande Woude, G.F.
Nature Reviews Molecular Cell Biology 4 (12): 915-925. December 2003

beta-catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system.
Zechner, D., Fujita, Y., Huelsken, J., Mueller, T., Walther, I., Taketo, M.M., Crenshaw, E.B., Birchmeier, W. and Birchmeier, C.
Developmental Biology 258 (2): 406-418. 15 June 2003

ErbB2 pathways in heart and neural diseases.
Garratt, A.N., Ozcelik, C. and Birchmeier, C.
Trends in Cardiovascular Medicine 13 (2): 80-86. February 2003

Acquisition of neuronal and glial markers by neural crest-derived cells in the mouse intestine.
Young, H.M., Bergner, A.J. and Mueller, T.
Journal of Comparative Neurology 456 (1): 1-11. 27 January 2003

Tiermodelle in der biomedizinischen Forschung.
Britsch, S., Strehle, M. and Birchmeier, C.
In: Grundlagen der Molekularen Medizin. Molekulare Medizin . Springer, Berlin [u.a.], 299-339. ISBN 3-540-43207-8 1 January 2003

2002

A role for Neuregulin1 signaling in muscle spindle differentiation.
Hippenmeyer, S., Shneider, N.A., Birchmeier, C., Burden, S.J., Jessell, T.M. and Arber, S.
Neuron 36 (6): 1035-1049. 19 December 2002

Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy.
Özcelik, C., Erdmann, B., Pilz, B., Wettschureck, N., Britsch, S., Hübner, N., Chien, K.R., Birchmeier, C. and Garratt, A.N.
Proceedings of the National Academy of Sciences of the United States of America 99 (13): 8880-8885. 25 June 2002

Sensory nerves determine the pattern of arterial differentiation and blood vessel branching in the skin.
Mukouyama, Y., Shin, D., Britsch, S., Taniguchi, M. and Anderson, D.J.
Cell 109 (6): 693-705. 14 June 2002

Trastuzumab cardiotoxicity: Speculations regarding pathophysiology and targets for further study.
Schneider, J.W., Chang, A.Y. and Garratt, A.
Seminars in Oncology 29 (3): 22-28. June 2002

The homeodomain factor Lbx1 distinguishes two major programs of neuronal differentiation in the dorsal spinal cord.
Müller, T., Brohmann, H., Pierani, A., Heppenstall, P.A., Lewin, G.R., Jessell, T.M. and Birchmeier, C.
Neuron 34 (4): 551-562. 16 May 2002

The breast proto-oncogene, HRGalpha regulates epithelial proliferation and lobuloalveolar development in the mouse mammary gland.
Li, L., Cleary, S., Mandarano, M.A., Long, W.W., Birchmeier, C. and Jones, F.E.
Oncogene 21 : 4900-4907. 1 January 2002

2001

Genomics boosts mouse molecular genetics.
Birchmeier, C. and Treier, M.
Trends in Genetics 17 (12): 691-692. 1 December 2001

Genetische Analyse des Tyrosinkinase-Rezeptors ErbB2.
Woldeyesus, M.T.
UNSPECIFIED thesis, UNSPECIFIED. 14 February 2001

Negative regulation of Ros receptor tyrosine kinase signaling: An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1.
Keilhack, H., Mueller, M., Boehmer, S.A., Frank, C., Weidner, K.M., Birchmeier, W., Ligensa, T., Berndt, A., Kosmehl, H., Gunther, B., Mueller, T., Birchmeier, C. and Boehmer, F.D.
Journal of Cell Biology 152 (2): 325-334. 22 January 2001

Patterning of muscle acetylcholine receptor gene expression in the absence of motor innervation.
Yang, X., Arber, S., William, C., Li, L., Tanabe, Y., Jessell, T.M., Birchmeier, C. and Burden, S.J.
Neuron 30 (2): 399-410. 1 January 2001

The transcription factor Sox10 is a key regulator of peripheral glial development.
Britsch, S., Goerich, D.E., Riethmacher, D., Peirano, R.I., Rossner, M., Nave, K.A., Birchmeier, C. and Wegner, M.
Genes & Development 15 (1): 66-78. 1 January 2001

2000

Verfahren zur Herstellung von universell einsetzbaren Feeder-Matrix-Schalen und ihre Verwendung zur Kultivierung von embryonalen Stammzellen jeglicher Art.
Garratt, A. and Buchert, S.
DE19929469A1. 28 December 2000

Cell differentiation.
Rosenthal, N. and Birchmeier, C.
Current Opinion in Cell Biology 12 : 717-718. 1 December 2000

Genes that control the development of migrating muscle precursor cells.
Birchmeier, C. and Brohmann, H.
Current Opinion in Cell Biology 12 (6): 725-730. 1 December 2000

Neuregulin, a factor with many functions in the life of schwann cell.
Garratt, A.N., Britsch, S. and Birchmeier, C.
BioEssays 22 (11): 987-996. November 2000

E-cadherin and adenomatous polyposis coli mutations are synergistic in intestinal tumor initiation in mice.
Smits, R., Ruiz, P., Diaz-Cano, S., Luz, A., Jagmohan-Changur, S., Breukel, C., Birchmeier, C., Birchmeier, W. and Fodde, R.
Gastroenterology 119 (4): 1045-1053. 1 October 2000

Essential role of Gab1 for signaling by the c-Met receptor in vivo.
Sachs, M., Brohmann, H., Zechner, D., Mueller, T., Huelsken, J., Walther, I., Schaeper, U., Birchmeier, C. and Birchmeier, W.
Journal of Cell Biology 150 (6): 1375-1384. 18 September 2000

The branchial arches and HGF are growth-promoting and chemoattractant for cranial motor axons.
Caton, A., Hacker, A., Naeem, A., Livet, J., Maina, F., Bladt, F., Klein, R., Birchmeier, C. and Guthrie, S.
Development 127 (8): 1751-1766. 1 April 2000

A dual role of erbB2 in myelination and in expansion of the Schwann cell precursor pool.
Garratt, A.N., Voiculescu, O., Topilko, P., Charnay, P. and Birchmeier, C.
Journal of Cell Biology 148 (5): 1035-1046. 6 March 2000

Requirement for beta-catenin in anterior-posterior axis formation in mice.
Huelsken, J., Vogel, R., Brinkmann, V., Erdmann, B., Birchmeier, C. and Birchmeier, W.
Journal of Cell Biology 148 (3): 567-578. 7 February 2000

The role of Lbx1 in migration of muscle precursor cells.
Brohmann, H., Jagla, K. and Birchmeier, C.
Development 127 (2): 437-445. 1 January 2000

1999

A role of the cryptic gene in the correct establishment of the left-right axis.
Gaio, U., Schweickert, A., Fischer, A., Garratt, A.N., Mueller, T., Oezcelik, C., Lankes, W., Strehle, M., Britsch, S., Blum, M. and Birchmeier, C.
Current Biology 9 (22): 1339-1342. 18 November 1999

Peripheral nervous system defects in erbB2 mutants following genetic rescue of heart development.
Woldeyesus, M.T., Britsch, S., Riethmacher, D., Xu, L., Sonnenberg-Riethmacher, E., Abou-Rebyeh, F., Harvey, R., Caroni, P. and Birchmeier, C.
Genes & Development 13 : 2538-2548. 1 October 1999

MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis.
Kotlyarov, A., Neininger, A., Schubert, C., Eckert, R., Birchmeier, C., Volk, H.D. and Gaestel, M.
Nature Cell Biology 1 : 94-97. 1 June 1999

The role of SF/HGF and c-Met in the development of skeletal muscle.
Dietrich, S., Abou-Rebyeh, F., Brohmann, H., Bladt, F., Yamaai, T., Lumsden, A., Brand-Saberi, B. and Birchmeier, C.
Development 126 : 1621-1629. 1 April 1999

10. Tyrosine kinase receptors as driving forces for growth, motility and differentiation of epithelial cells.
Birchmeier, W., Birchmeier, C., Brinkmann, V. and Niemann, C.
In: Epithelial Morphogenesis in Development and Disease. Cell Adhesion and Communication . Harwood Acad. Publ., Amsterdam [u.a.], 217-231. 1 January 1999

Epithelial Morphogenesis in Development and Disease.
Birchmeier, W. and Birchmeier, C.
Cell Adhesion and Communication . Harwood Acad. Publ., Amsterdam [u.a.]. 1 January 1999

1998

Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinase.
Birchmeier, C. and Gherardi, E.
Trends in Cell Biology 8 (10): 404-410. 1 October 1998

Engineered mutants of HGF/SF with reduced binding to heparan sulphate proteoglycans, decreased clearance and enhanced activity in vivo.
Hartmann, G., Prospero, T., Brinkmann, V., Ozcelik, O., Winter, G., Hepple, J., Batley, S., Bladt, F., Sachs, M., Birchmeier, C., Birchmeier, W. and Gherardi, E.
Current Biology 8 (3): 125-134. 29 January 1998

Sustained long-term potentiation and anxiety in mice lacking the Mas protooncogene.
Walther, T., Balschun, D., Voigt, J.P., Fink, H., Zuschratter, W., Birchmeier, C., Ganten, D. and Bader, M.
Journal of Biological Chemistry 273 : 11867-11873. 1 January 1998

The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system.
Britsch, S., Li, L., Kirchhoff, S., Theuring, F., Brinkmann, V., Birchmeier, C. and Riethmacher, D.
Genes & Development 12 : 1825-1836. 1 January 1998

1997

Hepatocyte growth factor/scatter factor is an axonal chemoattractant and a neurotrophic factor for spinal motor neurons.
Ebens, A., Brose, K., Leonardo, E.D., Hanson, M.G., Bladt, F., Birchmeier, C., Barres, B.A. and Tessierlavigne, M.
Neuron 17 (6): 1157-1172. 1 December 1997

Severe neuropathies in mice with targeted mutations in the ErbB3 receptor.
Riethmacher, D., Sonnenberg-Riethmacher, E., Brinkmann, V., Yamaai, T., Lewin, G.R. and Birchmeier, C.
Nature 389 (6652): 725-730. 16 October 1997

Isoform specific expression and function of neuregulin.
Meyer, D., Yamaai, T., Garratt, A., Riethmacher-Sonnenberg, E., Kane, D., Theill, L.E. and Birchmeier, C.
Development 124 (18): 3575-3586. September 1997

Met -/- kidneys express epithelial cells that chemotax and form tubules in response to EGF receptor ligands.
Kjelsberg, C., Sakurai, H., Spokes, K., Birchmeier, C., Drummond, I., Nigam, S. and Cantley, L.G.
American Journal of Physiology Renal Physiology 272 : F222-F228. 1 January 1997

Morphogenesis of epithelial cells.
Birchmeier, C., Riethmacher, D. and Brinkmann, V.
In: Adhesion Molecules in Health and Disease. Marcel Dekker,Inc., New York, 205-222. 1 January 1997

The functions of HGF/SF and its receptor, the c-Met tyrosine kinase, in mammalian development.
Birchmeier, C., Bladt, F. and Yamaai, T.
Ciba Foundation Symposia 212 : 169-177, discussion 177-82.. 1 January 1997

Tiermodelle in der biomedizinischen Forschung.
Birchmeier, C., Bladt, F. and Britsch, S.
In: Molekular- und Zellbiologische Grundlagen. Handbuch der Molekularen Medizin ; 1 . Springer, Berlin [u.a.], 338-358. 1 January 1997

1996

Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart.
Ruiz, P., Brinkmann, V., Ledermann, B., Behrend, M., Grund, C., Thalhammer, C., Vogel, F., Birchmeier, C., Guenthert, U., Franke, W.W. and Birchmeier, W.
Journal of Cell Biology 135 (1): 215-225. October 1996

Epithelial differentiation and the control of metastasis in carcinomas.
Birchmeier, W., Behrens, J., Weidner, K.M., Huelsken, J. and Birchmeier, C.
Current Topics in Microbiology and Immunology : 117-135. 1 January 1996

Epithelial-mesenchymal transitions in cancer progression.
Birchmeier, C., Birchmeier, W. and Brand-Saberi, B.
Acta Anatomica 156 : 217-226. 1 January 1996

Scatter factor hepatocyte growth factor (sf/hgf) induces emigration of myogenic cells at interlimb level in vivo.
Brand-Saberi, B., Mueller, T.S., Wilting, J., Christ, B. and Birchmeier, C.
Developmental Biology 179 : 303-308. 1 January 1996

The c-ros tyrosine kinase receptor controls regionalization and differentiation of epithelial cells in the epididymis.
Sonnenberg-Riethmacher, E., Walter, B., Riethmacher, D., Goedecke, S. and Birchmeier, C.
Genes & Development 10 (10): 1184-1193. 1 January 1996

1995

Multiple essential functions of neuregulin in development.
Meyer, D. and Birchmeier, C.
Nature 378 (6555): 386-390. 23 November 1995

Sequential requirement of hepatocyte growth factor and neuregulin in the morphogenesis and differentiation of the mammary gland.
Yang, Y., Spitzer, E., Meyer, D., Sachs, M., Niemann, C., Hartmann, G., Weidner, K.M., Birchmeier, C. and Birchmeier, W.
Journal of Cell Biology 131 (1): 215-226. October 1995

Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud.
Bladt, F., Riethmacher, D., Isenmann, S., Aguzzi, A. and Birchmeier, C.
Nature 376 (6543): 768-771. 31 August 1995

Scatter factor/hepatocyte growth factor is essential for liver development.
Schmidt, C., Bladt, F., Goedecke, S., Brinkmann, V., Zschiesche, W., Sharpe, M., Gherardi, E. and Birchmeier, C.
Nature 373 (6515): 699-702. 23 February 1995

A targeted mutation in the mouse E-cadherin gene results in defective preimplantation development.
Riethmacher, D., Brinkmann, V. and Birchmeier, C.
Proceedings of the National Academy of Sciences of the United States of America 92 (3): 855-859. 31 January 1995

Epithelial-mesenchymal transitions in development and tumor progression.
Birchmeier, W. and Birchmeier, C.
In: Epithelial-Mesenchymal Interactions in Cancer. Birkhaeuser, Basel, 1-15. 1 January 1995

Factors controlling growth, motility, and morphogenesis of normal and malignant epithelial cells.
Birchmeier, C., Meyer, D. and Riethmacher, D.
International Review of Cytology 160 : 221-266. 1 January 1995

1994

Biochemical and functional characterization of the murine ros protooncogene.
Riethmacher, D., Langholz, O., Goedecke, S., Sachs, M. and Birchmeier, C.
Oncogene 9 (12): 3617-3626. December 1994

Distinct isoforms of neuregulin are expressed in mesenchymal and neuronal cells during mouse development.
Meyer, D. and Birchmeier, C.
Proceedings of the National Academy of Sciences of the United States of America 91 : 1064-1068. 1 January 1994

Mesenchymal-epithelial transitions.
Birchmeier, W. and Birchmeier, C.
BioEssays 16 : 305-307. 1 January 1994

1993

Differential expression of neurotrophin receptors during renal development.
Durbeej, M., Soederstroem, S., Ebendal, T., Birchmeier, C. and Ekblom, P.
Development 119 (4): 977-989. December 1993

Scatter factor/hepatocyte growth factor and its receptor, the c-met tyrosine kinase, can mediate a signal exchange between mesenchyme and epithelia during mouse development.
Sonnenberg, E., Meyer, D., Weidner, K.M. and Birchmeier, C.
Journal of Cell Biology 123 (1): 223-235. 1 October 1993

Characterization and expression analysis of the murine rck gene - a protein-kinase with a potential function in sensory cells.
Bladt, F. and Birchmeier, C.
Differentiation 53 : 115-122. 1 January 1993

Expression of the met-receptor and its ligand, HGF-SF during mouse embryogenesis.
Sonnenberg, E., Weidner, K.M. and Birchmeier, C.
In: Hepatocyte Growth Factor-Scatter Factor (HGF-SF) and the C-Met-Receptor. Birkhaeuser, Basel [u.a.], 381-394. 1 January 1993

Tyrosine kinase receptors in the control of epithelial growth and morphogenesis during development.
Birchmeier, C., Sonnenberg, E., Weidner, K.M. and Walter, B.
BioEssays 15 : 185-190. 1 January 1993

Molecular aspects of mesenchymal-epithelial interactions.
Birchmeier, C. and Birchmeier, W.
Annual Review of Cell Biology 9 : 511-540. 1993