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| Item Type: | Article |
|---|---|
| Title: | dILA neurons in the dorsal spinal cord are the product of terminal and non-terminal asymmetric progenitor cell divisions, and require Mash1 for their development |
| Creators: |
Wildner, H., Mueller, T.  ORCID: https://orcid.org/0000-0001-8096-1853, Cho, S.H., Broehl, D., Cepko, C.L., Guillemot, F. and Birchmeier, C. ORCID: https://orcid.org/0000-0002-2041-8872
|
| Abstract: | dILA and dILB neurons comprise the major neuronal subtypes generated in the dorsal spinal cord, and arise in a salt-and-pepper pattern from a broad progenitor domain that expresses the bHLH factor Mash1. In this domain, Mash1-positive and Mash1-negative cells intermingle. Using a Mash1(GFP) allele in mice, we show here that Mash1+ progenitors give rise to dILA and dILB neurons. Using retroviral tracing in the chick, we demonstrate that a single progenitor can give rise to a dILA and a dILB neuron, and that dILA neurons are the product of asymmetric progenitor cell divisions. In Mash1-null mutant mice, the development of dILA, but not of dILB neurons is impaired. We provide evidence that a dual function of Mash1 in neuronal differentiation and specification accounts for the observed changes in the mutant mice. Our data allow us to assign to Mash1 a function in asymmetric cell divisions, and indicate that the factor coordinates cell cycle exit and specification in the one daughter that gives rise to a dILA neuron. |
| Keywords: | Asymmetric Cell Division, Neuronal Specification, Spinal Cord, Mash1 (Ascl1), Animals, Mice, Chickens |
| Source: | Development |
| ISSN: | 0950-1991 |
| Publisher: | Company of Biologists |
| Volume: | 133 |
| Number: | 11 |
| Page Range: | 2105-2113 |
| Date: | 1 June 2006 |
| Official Publication: | https://doi.org/10.1242/dev.02345 |
| PubMed: | View item in PubMed |
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