Browse by Journal Title

2024

Multiple myeloma long-term survivors exhibit sustained immune alterations decades after first-line therapy.
Lutz, R., Grünschläger, F., Simon, M., Awwad, M.H.S., Bauer, M., Yousefian, S., Beumer, N., Jopp-Saile, L., Sedlmeier, A., Solé-Boldo, L., Avanesyan, B., Vonficht, D., Stelmach, P., Steinbuss, G., Boch, T., Steiger, S., Baertsch, M.A., Prokoph, N., Rippe, K., Durie, B.G.M., Wickenhauser, C., Trumpp, A., Müller-Tidow, C., Hübschmann, D., Weinhold, N., Raab, M.S., Brors, B., Goldschmidt, H., Imbusch, C.D., Hundemer, M. and Haas, S.
Nature Communications 15 (1): 10396. 29 November 2024

Cognitive reserve against Alzheimer's pathology is linked to brain activity during memory formation.
Vockert, N., Machts, J., Kleineidam, L., Nemali, A., Incesoy, E.I., Bernal, J., Schütze, H., Yakupov, R., Peters, O., Gref, D., Schneider, L.S., Preis, L., Priller, J., Spruth, E.J., Altenstein, S., Schneider, A., Fliessbach, K., Wiltfang, J., Rostamzadeh, A., Glanz, W., Teipel, S., Kilimann, I., Goerss, D., Laske, C., Munk, M.H., Spottke, A., Roy, N., Heneka, M.T., Brosseron, F., Wagner, M., Wolfsgruber, S., Dobisch, L., Dechent, P., Hetzer, S., Scheffler, K., Zeidman, P., Stern, Y., Schott, B.H., Jessen, F., Düzel, E., Maass, A. and Ziegler, G.
Nature Communications 15 (1): 9815. 13 November 2024

Structure, interaction and nervous connectivity of beta cell primary cilia.
Müller, A., Klena, N., Pang, S., Garcia, L.E.G., Topcheva, O., Aurrecoechea Duran, S., Sulaymankhil, D., Seliskar, M., Mziaut, H., Schöniger, E., Friedland, D., Kipke, N., Kretschmar, S., Münster, C., Weitz, J., Distler, M., Kurth, T., Schmidt, D., Hess, H.F., Xu, C.S., Pigino, G. and Solimena, M.
Nature Communications 15 (1): 9168. 24 October 2024

Reassessment of marker genes in human induced pluripotent stem cells for enhanced quality control.
Dobner, J., Diecke, S., Krutmann, J., Prigione, A. and Rossi, A.
Nature Communications 15 (1): 8547. 2 October 2024

Cell swelling enhances ligand-driven β-adrenergic signaling.
Sirbu, A., Bathe-Peters, M., Kumar, J.L.M, Inoue, A., Lohse, M.J. and Annibale, P.
Nature Communications 15 (1): 7822. 7 September 2024

A catalog of small proteins from the global microbiome.
Duan, Y., Santos-Júnior, C.D., Schmidt, T.S., Fullam, A., de Almeida, B.L.S., Zhu, C., Kuhn, M., Zhao, X.M., Bork, P. and Coelho, L.P.
Nature Communications 15 (1): 7563. 31 August 2024

Histone H3.3 lysine 9 and 27 control repressive chromatin at cryptic enhancers and bivalent promoters.
Trovato, M., Bunina, D., Yildiz, U., Fernandez-Novel Marx, N., Uckelmann, M., Levina, V., Perez, Y., Janeva, A., Garcia, B.A., Davidovich, C., Zaugg, J.B. and Noh, K.M.
Nature Communications 15 (1): 7557. 30 August 2024

Mutant huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure.
Lisowski, P., Lickfett, S., Rybak-Wolf, A., Menacho, C., Le, S., Pentimalli, T.M., Notopoulou, S., Dykstra, W., Oehler, D., López-Calcerrada, S., Mlody, B., Otto, M., Wu, H., Richter, Y., Roth, P., Anand, R., Kulka, L.A.M., Meierhofer, D., Glazar, P., Legnini, I., Telugu, N.S., Hahn, T., Neuendorf, N., Miller, D.C., Böddrich, A., Polzin, A., Mayatepek, E., Diecke, S., Olzscha, H., Kirstein, J., Ugalde, C., Petrakis, S., Cambridge, S., Rajewsky, N., Kühn, R., Wanker, E.E., Priller, J., Metzger, J.J. and Prigione, A.
Nature Communications 15 (1): 7027. 22 August 2024

Covalent penicillin-protein conjugates elicit anti-drug antibodies that are clonally and functionally restricted.
Deimel, L.P., Moynié, L., Sun, G., Lewis, V., Turner, A., Buchanan, C.J., Burnap, S.A., Kutuzov, M., Kobras, C.M., Demyaneko, Y., Mohammed, S., Stracy, M., Struwe, W.B., Baldwin, A.J., Naismith, J., Davis, B.G. and Sattentau, Q.J.
Nature Communications 15 (1): 6851. 10 August 2024

Evolution of retinal degeneration and prediction of disease activity in relapsing and progressive multiple sclerosis.
Krämer, J., Balloff, C., Weise, M., Koska, V., Uthmeier, Y., Esderts, I., Nguyen-Minh, M., Zimmerhof, M., Hartmann, A., Dietrich, M., Ingwersen, J., Lee, J.I., Havla, J., Kümpfel, T., Kerschensteiner, M., Häußler, V., Heesen, C., Stellmann, J.P., Zimmermann, H.G., Oertel, F.C., Ringelstein, M., Brandt, A.U., Paul, F., Aktas, O., Hartung, H.P., Wiendl, H., Meuth, S.G. and Albrecht, P.
Nature Communications 15 (1): 5243. 19 June 2024

mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism.
Levy, T., Voeltzke, K., Hruby, L., Alasad, K., Bas, Z., Snaebjörnsson, M., Marciano, R., Scharov, K., Planque, M., Vriens, K., Christen, S., Funk, C.M., Hassiepen, C., Kahler, A., Heider, B., Picard, D., Lim, J.K.M., Stefanski, A., Bendrin, K., Vargas-Toscano, A., Kahlert, U.D., Stühler, K., Remke, M., Elkabets, M., Grünewald, T.G.P., Reichert, A.S., Fendt, S.M., Schulze, A., Reifenberger, G., Rotblat, B. and Leprivier, G.
Nature Communications 15 (1): 4083. 14 May 2024

Multiscale modelling of chromatin 4D organization in SARS-CoV-2 infected cells.
Chiariello, A.M., Abraham, Alex, Bianco, S., Esposito, A., Fontana, A., Vercellone, F., Conte, M. and Nicodemi, M.
Nature Communications 15 (1): 4014. 13 May 2024

Complete male-to-female sex reversal in XY mice lacking the miR-17~92 cluster.
Hurtado, A., Mota-Gómez, I., Lao, M., Real, F.M., Jedamzick, J., Burgos, M., Lupiáñez, D.G., Jiménez, R. and Barrionuevo, F.J.
Nature Communications 15 (1): 3809. 7 May 2024

Antigen presentation plays positive roles in the regenerative response to cardiac injury in zebrafish.
Cardeira-da-Silva, J., Wang, Q., Sagvekar, P., Mintcheva, J., Latting, S., Günther, S., Ramadass, R., Yekelchyk, M., Preussner, J., Looso, M., Junker, J.P. and Stainier, D.Y.R.
Nature Communications 15 (1): 3637. 29 April 2024

CAR affinity modulates the sensitivity of CAR-T cells to PD-1/PD-L1-mediated inhibition.
Andreu-Saumell, I., Rodriguez-Garcia, A., Mühlgrabner, V., Gimenez-Alejandre, M., Marzal, B., Castellsagué, J., Brasó-Maristany, F., Calderon, H., Angelats, L., Colell, S., Nuding, M., Soria-Castellano, M., Barbao, P., Prat, A., Urbano-Ispizua, A., Huppa, J.B. and Guedan, S.
Nature Communications 15 (1): 3552. 26 April 2024

Pathogenic mutations of human phosphorylation sites affect protein–protein interactions.
Rrustemi, T., Meyer, K., Roske, Y., Uyar, B., Akalin, A., Imami, K., Ishihama, Y., Daumke, O. and Selbach, M.
Nature Communications 15 (1): 3146. 11 April 2024

Clinically used broad-spectrum antibiotics compromise inflammatory monocyte-dependent antibacterial defense in the lung.
Dörner, P.J., Anandakumar, H., Röwekamp, I., Fiocca Vernengo, F., Millet Pascual-Leone, B., Krzanowski, M., Sellmaier, J., Brüning, U., Fritsche-Guenther, R., Pfannkuch, L., Kurth, F., Milek, M., Igbokwe, V., Löber, U., Gutbier, B., Holstein, M., Heinz, G.A., Mashreghi, M.F., Schulte, L.N., Klatt, A.B., Caesar, S., Wienhold, S.M., Offermanns, S., Mack, M., Witzenrath, M., Jordan, S., Beule, D., Kirwan, J.A., Forslund, S.K., Wilck, N., Bartolomaeus, H., Heimesaat, M.M. and Opitz, B.
Nature Communications 15 (1): 2788. 30 March 2024

Ion mobility-tandem mass spectrometry of mucin-type O-glycans.
Bechtella, L., Chunsheng, J., Fentker, K., Ertürk, G.R., Safferthal, M., Polewski, Ł., Götze, M., Graeber, S.Y., Vos, G.M., Struwe, W.B., Mall, M.A., Mertins, P., Karlsson, N.G. and Pagel, K.
Nature Communications 15 (1): 2611. 23 March 2024

Heterozygous missense variant in GLI2 impairs human endocrine pancreas development.
Mueller, L.M., Isaacson, A., Wilson, H., Salowka, A., Tay, I., Gong, M., Samir Elbarbary, N., Raile, K. and Spagnoli, F.M.
Nature Communications 15 (1): 2483. 20 March 2024

Canonical and non-canonical integrin-based adhesions dynamically interconvert.
Lukas, F., Matthaeus, C., López-Hernández, T., Lahmann, I., Schultz, N., Lehmann, M., Puchkov, D., Pielage, J., Haucke, V. and Maritzen, T.
Nature Communications 15 (1): 2093. 7 March 2024

Transient disome complex formation in native polysomes during ongoing protein synthesis captured by cryo-EM.
Flügel, T., Schacherl, M., Unbehaun, A., Schroeer, B., Dabrowski, M., Bürger, J., Mielke, T., Sprink, T., Diebolder, C.A., Guillén Schlippe, Y.V. and Spahn, C.M.T.
Nature Communications 15 (1): 1756. 26 February 2024

MarShie: a clearing protocol for 3D analysis of single cells throughout the bone marrow at subcellular resolution.
Mertens, T.F., Liebheit, A.T., Ehl, J., Köhler, R., Rakhymzhan, A., Woehler, A., Katthän, L., Ebel, G., Liublin, W., Kasapi, A., Triantafyllopoulou, A., Schulz, T.J., Niesner, R.A. and Hauser, A.E.
Nature Communications 15 (1): 1764. 26 February 2024

Amyloid-β aggregates activate peripheral monocytes in mild cognitive impairment.
Juul-Madsen, K., Parbo, P., Ismail, R., Ovesen, P.L., Schmidt, V., Madsen, L.S., Thyrsted, J., Gierl, S., Breum, M., Larsen, A., Andersen, M.N., Romero-Ramos, M., Holm, C.K., Andersen, G.R., Zhao, H., Schuck, P., Nygaard, J.V., Sutherland, D.S., Eskildsen, S.F., Willnow, T.E., Brooks, D.J. and Vorup-Jensen, T.
Nature Communications 15 (1): 1224. 9 February 2024

Sensory Schwann cells set perceptual thresholds for touch and selectively regulate mechanical nociception.
Ojeda-Alonso, J., Calvo-Enrique, L., Paricio-Montesinos, R., Kumar, R., Zhang, M.D., Poulet, J.F.A., Ernfors, P. and Lewin, G.R.
Nature Communications 15 (1): 898. 6 February 2024

Logical design of synthetic cis-regulatory DNA for genetic tracing of cell identities and state changes.
Company, C., Schmitt, M.J., Dramaretska, Y., Serresi, M., Kertalli, S., Jiang, B., Yin, J.A., Aguzzi, A., Barozzi, I. and Gargiulo, G.
Nature Communications 15 (1): 897. 5 February 2024

Apoptosis-mediated ADAM10 activation removes a mucin barrier promoting T cell efferocytosis.
Drexhage, L.Z., Zhang, S., Dupont, M., Ragaller, F., Sjule, E., Cabezas-Caballero, J., Deimel, L.P., Robertson, H., Russell, R.A., Dushek, O., Sezgin, E., Karaji, N. and Sattentau, Q.J.
Nature Communications 15 (1): 541. 15 January 2024

Epstein-Barr virus-driven B cell lymphoma mediated by a direct LMP1-TRAF6 complex.
Giehler, F., Ostertag, M.S., Sommermann, T., Weidl, D., Sterz, K.R., Kutz, H., Moosmann, A., Feller, S.M., Geerlof, A., Biesinger, B., Popowicz, G.M., Kirchmair, J. and Kieser, A.
Nature Communications 15 (1): 414. 10 January 2024

2023

Efficient generation of a self-organizing neuromuscular junction model from human pluripotent stem cells.
Urzi, A., Lahmann, I., Nguyen, L.V.N., Rost, B.R., García-Pérez, A., Lelievre, N., Merritt-Garza, M.E., Phan, H.C, Bassell, G.J., Rossoll, W., Diecke, S., Kunz, S., Schmitz, D. and Gouti, M.
Nature Communications 14 (1): 8043. 19 December 2023

Direct-to-biology, automated, nano-scale synthesis, and phenotypic screening-enabled E3 ligase modulator discovery.
Wang, Z., Shaabani, S., Gao, X., Ng, Y.L.D., Sapozhnikova, V., Mertins, P., Krönke, J. and Dömling, A.
Nature Communications 14 (1): 8437. 19 December 2023

RIF1 regulates early replication timing in murine B cells.
Malzl, D., Peycheva, M., Rahjouei, A., Gnan, S., Klein, K.N., Nazarova, M., Schoeberl, U.E., Gilbert, D.M., Buonomo, S.C.B., Di Virgilio, M., Neumann, T. and Pavri, R.
Nature Communications 14 (1): 8049. 11 December 2023

Characterization of nucleolar SUMO isopeptidases unveils a general p53-independent checkpoint of impaired ribosome biogenesis.
Dönig, J., Mende, H., Davila Gallesio, J., Wagner, K., Hotz, P., Schunck, K., Piller, T., Hölper, S., Uhan, S., Kaulich, M., Wirth, M., Keller, U., Tascher, G., Bohnsack, K.E. and Müller, S.
Nature Communications 14 (1): 8121. 8 December 2023

The SPOC proteins DIDO3 and PHF3 co-regulate gene expression and neuronal differentiation.
Benedum, J., Franke, V., Appel, L.M., Walch, L., Bruno, M., Schneeweiss, R., Gruber, J., Oberndorfer, H., Frank, E., Strobl, X., Polyansky, A., Zagrovic, B., Akalin, A. and Slade, D.
Nature Communications 14 (1): 7912. 30 November 2023

Associations of myeloid cells with cellular and humoral responses following vaccinations in patients with neuroimmunological diseases.
Wang, M., Dehlinger, A., Fernández Zapata, C., Golan, M., Gallaccio, G., Sander, L.E., Schlickeiser, S., Kunkel, D., Schmitz-Hübsch, T., Sawitzki, B., Karni, A., Braun, J., Loyal, L., Thiel, A., Bellmann-Strobl, J., Paul, F., Meyer-Arndt, L. and Boettcher, C.
Nature Communications 14 (1): 7728. 25 November 2023

Transcriptional reprogramming by mutated IRF4 in lymphoma.
Schleussner, N., Cauchy, P., Franke, V., Giefing, M., Fornes, O., Vankadari, N., Assi, S.A., Costanza, M., Weniger, M.A., Akalin, A., Anagnostopoulos, I., Bukur, T., Casarotto, M.G., Damm, F., Daumke, O., Edginton-White, B., Gebhardt, J.C.M., Grau, M., Grunwald, S., Hansmann, M.L., Hartmann, S., Huber, L., Kärgel, E., Lusatis, S., Noerenberg, D., Obier, N., Pannicke, U., Fischer, A., Reisser, A., Rosenwald, A., Schwarz, K., Sundararaj, S., Weilemann, A., Winkler, W., Xu, W., Lenz, G., Rajewsky, K., Wasserman, W.W., Cockerill, P.N., Scheidereit, C., Siebert, R., Küppers, R., Grosschedl, R., Janz, M., Bonifer, C. and Mathas, S.
Nature Communications 14 (1): 6947. 7 November 2023

Streamlined structure determination by cryo-electron tomography and subtomogram averaging using TomoBEAR.
Balyschew, N., Yushkevich, A., Mikirtumov, V., Sanchez, R.M., Sprink, T. and Kudryashev, M.
Nature Communications 14 (1): 6543. 17 October 2023

European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation.
Budu-Aggrey, A., Kilanowski, A., Sobczyk, M.K., Shringarpure, S.S., Mitchell, R., Reis, K., Reigo, A., Mägi, R., Nelis, M., Tanaka, N., Brumpton, B.M., Thomas, L.F., Sole-Navais, P., Flatley, C., Espuela-Ortiz, A., Herrera-Luis, E., Lominchar, J.V.T., Bork-Jensen, J., Marenholz, I., Arnau-Soler, A., Jeong, A., Fawcett, K.A., Baurecht, H., Rodriguez, E., Alves, A.C., Kumar, A., Sleiman, P.M., Chang, X., Medina-Gomez, C., Hu, C., Xu, C.J., Qi, C., El-Heis, S., Titcombe, P., Antoun, E., Fadista, J., Wang, C.A., Thiering, E., Wu, B., Kress, S., Kothalawala, D.M., Kadalayil, L., Duan, J., Zhang, H., Hadebe, S., Hoffmann, T., Jorgenson, E., Choquet, H., Risch, N., Njølstad, P., Andreassen, O.A., Johansson, S., Almqvist, C., Gong, T., Ullemar, V., Karlsson, R., Magnusson, P.K.E., Szwajda, A., Burchard, E.G., Thyssen, J.P., Hansen, T., Kårhus, L.L., Dantoft, T.M., Jeanrenaud, A.C.S.N., Ghauri, A., Arnold, A., Homuth, G., Lau, S., Nöthen, M.M., Hübner, N., Imboden, M., Visconti, A., Falchi, M., Bataille, V., Hysi, P., Ballardini, N., Boomsma, D.I., Hottenga, J.J., Müller-Nurasyid, M., Ahluwalia, T.S., Stokholm, J., Chawes, B., Schoos, A.M.M., Esplugues, A., Bustamante, M., Raby, B., Arshad, S., German, C., Esko, T., Milani, L.A., Metspalu, A., Terao, C., Abuabara, K., Løset, M., Hveem, K., Jacobsson, B., Pino-Yanes, M., Strachan, D.P., Grarup, N., Linneberg, A., Lee, Y., Probst-Hensch, N., Weidinger, S., Jarvelin, M.R., Melén, E., Hakonarson, H., Irvine, A.D., Jarvis, D., Nijsten, T., Duijts, L., Vonk, J.M., Koppelmann, G.H., Godfrey, K.M., Barton, S.J., Feenstra, B., Pennell, C.E., Sly, P.D., Holt, P.G., Williams, L.K., Bisgaard, H., Bønnelykke, K., Curtin, J., Simpson, A., Murray, C., Schikowski, T., Bunyavanich, S., Weiss, S.T., Holloway, J.W., Min, J.L., Brown, S.J., Standl, M. and Paternoster, L.
Nature Communications 14 (1): 6172. 4 October 2023

Evidence of a causal and modifiable relationship between kidney function and circulating trimethylamine N-oxide.
Andrikopoulos, P., Aron-Wisnewsky, J., Chakaroun, R., Myridakis, A., Forslund, S.K., Nielsen, T., Adriouch, S., Holmes, B., Chilloux, J., Vieira-Silva, S., Falony, G., Salem, J.E., Andreelli, F., Belda, E., Kieswich, J., Chechi, K., Puig-Castellvi, F., Chevalier, M., Le Chatelier, E., Olanipekun, M.T., Hoyles, L., Alves, R., Helft, G., Isnard, R., Køber, L., Coelho, L.P., Rouault, C., Gauguier, D., Gøtze, J.P., Prifti, E., Froguel, P., Zucker, J.D., Bäckhed, F., Vestergaard, H., Hansen, T., Oppert, J.M., Blüher, M., Nielsen, J., Raes, J., Bork, P., Yaqoob, M.M., Stumvoll, M., Pedersen, O., Ehrlich, S.D., Clément, K. and Dumas, M.E.
Nature Communications 14 (1): 5843. 20 September 2023

Loss of microglial MCT4 leads to defective synaptic pruning and anxiety-like behavior in mice.
Monsorno, K., Ginggen, K., Ivanov, A., Buckinx, A., Lalive, A.L., Tchenio, A., Benson, S., Vendrell, M., D'Alessandro, A., Beule, D., Pellerin, L., Mameli, M. and Paolicelli, R.C.
Nature Communications 14 (1): 5749. 16 September 2023

The interplay between dietary fatty acids and gut microbiota influences host metabolism and hepatic steatosis.
Schoeler, M., Ellero-Simatos, S., Birkner, T., Mayneris-Perxachs, J., Olsson, L., Brolin, H., Löber, U., Kraft, J.D., Polizzi, A., Martí-Navas, M., Puig, J., Moschetta, A., Montagner, A., Gourdy, P., Heymes, C., Guillou, H., Tremaroli, V., Fernández-Real, J.M., Forslund, S.K., Burcelin, R. and Caesar, R.
Nature Communications 14 (1): 5329. 1 September 2023

Impaired Plakophilin-2 in obesity breaks cell cycle dynamics to breed adipocyte senescence.
Lluch, A., Latorre, J., Serena-Maione, A., Espadas, I., Caballano-Infantes, E., Moreno-Navarrete, J.M., Oliveras-Cañellas, N., Ricart, W., Malagón, M.M., Martin-Montalvo, A., Birchmeier, W., Szymanski, W., Graumann, J., Gómez-Serrano, M., Sommariva, E., Fernández-Real, J.M. and Ortega, F.J.
Nature Communications 14 (1): 5106. 22 August 2023

Resolving the spatial architecture of myeloma and its microenvironment at the single-cell level.
John, L., Poos, A.M., Brobeil, A., Schinke, C., Huhn, S., Prokoph, N., Lutz, R., Wagner, B., Zangari, M., Tirier, S.M., Mallm, J.P., Schumacher, S., Vonficht, D., Solé-Boldo, L., Quick, S., Steiger, S., Przybilla, M.J., Bauer, K., Baumann, A., Hemmer, S., Rehnitz, C., Lückerath, C., Sachpekidis, C., Mechtersheimer, G., Haberkorn, U., Dimitrakopoulou-Strauss, A., Reichert, P., Barlogie, B., Müller-Tidow, C., Goldschmidt, H., Hillengass, J., Rasche, L., Haas, S.F., van Rhee, F., Rippe, K., Raab, M.S., Sauer, S. and Weinhold, N.
Nature Communications 14 (1): 5011. 17 August 2023

Robust phenotyping of highly multiplexed tissue imaging data using pixel-level clustering.
Liu, C.C., Greenwald, N.F., Kong, A., McCaffrey, E.F., Leow, K.X., Mrdjen, D., Cannon, B.J., Rumberger, J.L., Varra, S.R. and Angelo, M.
Nature Communications 14 (1): 4618. 1 August 2023

Mislocalization of pathogenic RBM20 variants in dilated cardiomyopathy is caused by loss-of-interaction with Transportin-3.
Kornienko, J., Rodríguez-Martínez, M., Fenzl, K., Hinze, F., Schraivogel, D., Grosch, M., Tunaj, B., Lindenhofer, D., Schraft, L., Kueblbeck, M., Smith, E., Mao, C., Brown, E., Owens, A., Saguner, A.M., Meder, B., Parikh, V., Gotthardt, M. and Steinmetz, L.M.
Nature Communications 14 (1): 4312. 18 July 2023

Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction.
Yeh, Y.T., Sona, C., Yan, X., Li, Y., Pathak, A., McDermott, M.I., Xie, Z., Liu, L., Arunagiri, A., Wang, Y., Cazenave-Gassiot, A., Ghosh, A., von Meyenn, F., Kumarasamy, S., Najjar, S.M., Jia, S., Wenk, M.R., Traynor-Kaplan, A., Arvan, P., Barg, S., Bankaitis, V.A. and Poy, M.N.
Nature Communications 14 (1): 4250. 17 July 2023

Defining the landscape of circular RNAs in neuroblastoma unveils a global suppressive function of MYCN.
Fuchs, S., Danßmann, C., Klironomos, F., Winkler, A., Fallmann, J., Kruetzfeldt, L.M., Szymansky, A., Naderi, J., Bernhart, S.H., Grunewald, L., Helmsauer, K., Rodriguez-Fos, E., Kirchner, M., Mertins, P., Astrahantseff, K., Suenkel, C., Toedling, J., Meggetto, F., Remke, M., Stadler, P.F., Hundsdoerfer, P., Deubzer, H.E., Künkele, A., Lang, P., Fuchs, J., Henssen, A.G., Eggert, A., Rajewsky, N., Hertwig, F. and Schulte, J.H.
Nature Communications 14 (1): 3936. 4 July 2023

Striated muscle-specific base editing enables correction of mutations causing dilated cardiomyopathy.
Grosch, M., Schraft, L., Chan, A., Küchenhoff, L., Rapti, K., Ferreira, A.M., Kornienko, J., Li, S., Radke, M.H., Krämer, C., Clauder-Münster, S., Perlas, E., Backs, J., Gotthardt, M., Dieterich, C., van den Hoogenhof, M.M.G., Grimm, D. and Steinmetz, L.M.
Nature Communications 14 (1): 3714. 22 June 2023

Establishment of gastrointestinal assembloids to study the interplay between epithelial crypts and their mesenchymal niche.
Lin, M., Hartl, K., Heuberger, J., Beccaceci, G., Berger, H., Li, H., Liu, L., Müllerke, S., Conrad, T., Heymann, F., Woehler, A., Tacke, F., Rajewsky, N. and Sigal, M.
Nature Communications 14 (1): 3025. 25 May 2023

Endothelial FAT1 inhibits angiogenesis by controlling YAP/TAZ protein degradation via E3 ligase MIB2.
Li, R., Shao, J., Jin, Y.J., Kawase, H., Ong, Y.T., Troidl, K., Quan, Q., Wang, L., Bonnavion, R., Wietelmann, A., Helmbacher, F., Potente, M., Graumann, J., Wettschureck, N. and Offermanns, S.
Nature Communications 14 (1): 1980. 8 April 2023

Role of TMEM100 in mechanically insensitive nociceptor un-silencing.
Nees, T.A., Wang, N., Adamek, P., Zeitzschel, N., Verkest, C., La Porta, C., Schaefer, I., Virnich, J., Balkaya, S., Prato, V., Morelli, C., Begay, V., Lee, Y.J., Tappe-Theodor, A., Lewin, G.R., Heppenstall, P.A., Taberner, F.J. and Lechner, S.G.
Nature Communications 14 (1): 1899. 5 April 2023

The dynamic nature of netrin-1 and the structural basis for glycosaminoglycan fragment-induced filament formation.
Meier, M., Gupta, M., Akgül, S., McDougall, M., Imhof, T., Nikodemus, D., Reuten, R., Moya-Torres, A., To, V., Ferens, F., Heide, F., Padilla-Meier, G.P., Kukura, P., Huang, W., Gerisch, B., Mörgelin, M., Poole, K., Antebi, A., Koch, M. and Stetefeld, J.
Nature Communications 14 (1): 1226. 3 March 2023

Differential regulation of mRNA stability modulates transcriptional memory and facilitates environmental adaptation.
Li, B., Zeis, P., Zhang, Y., Alekseenko, A., Fürst, E., Sanchez, Y.P., Lin, G., Tekkedil, M.M., Piazza, I., Steinmetz, L.M. and Pelechano, V.
Nature Communications 14 (1): 910. 17 February 2023

Cryo-EM captures early ribosome assembly in action.
Qin, B., Lauer, S.M., Balke, A., Vieira-Vieira, C.H., Bürger, J., Mielke, T., Selbach, M., Scheerer, P., Spahn, C.M.T. and Nikolay, R.
Nature Communications 14 (1): 898. 17 February 2023

Distinct tissue niches direct lung immunopathology via CCL18 and CCL21 in severe COVID-19.
Mothes, R., Pascual-Reguant, A., Koehler, R., Liebeskind, J., Liebheit, A., Bauherr, S., Philipsen, L., Dittmayer, C., Laue, M., von Manitius, R., Elezkurtaj, S., Durek, P., Heinrich, F., Heinz, G.A., Guerra, G.M., Obermayer, B., Meinhardt, J., Ihlow, J., Radke, J., Heppner, F.L., Enghard, P., Stockmann, H., Aschman, T., Schneider, J., Corman, V.M., Sander, L.E., Mashreghi, M.F., Conrad, T., Hocke, A.C., Niesner, R.A., Radbruch, H. and Hauser, A.E.
Nature Communications 14 (1): 791. 11 February 2023

The SPOC domain is a phosphoserine binding module that bridges transcription machinery with co- and post-transcriptional regulators.
Appel, L.M., Franke, V., Benedum, J., Grishkovskaya, I., Strobl, X., Polyansky, A., Ammann, G., Platzer, S., Neudolt, A., Wunder, A., Walch, L., Kaiser, S., Zagrovic, B., Djinovic-Carugo, K., Akalin, A. and Slade, D.
Nature Communications 14 (1): 166. 11 January 2023

2022

Modulating glycosphingolipid metabolism and autophagy improves outcomes in pre-clinical models of myeloma bone disease.
Leng, H., Zhang, H., Li, L., Zhang, S., Wang, Y., Chavda, S.J., Galas-Filipowicz, D., Lou, H., Ersek, A., Morris, E.V., Sezgin, E., Lee, Y.H., Li, Y., Lechuga-Vieco, A.V., Tian, M., Mi, J.Q., Yong, K., Zhong, Q., Edwards, C.M., Simon, A.K. and Horwood, N.J.
Nature Communications 13 (1): 7868. 22 December 2022

Calcium-permeable channelrhodopsins for the photocontrol of calcium signalling.
Fernandez Lahore, R.G., Pampaloni, N.P., Schiewer, E., Heim, M.M., Tillert, L., Vierock, J., Oppermann, J., Walther, J., Schmitz, D., Owald, D., Plested, A.J.R., Rost, B.R. and Hegemann, P.
Nature Communications 13 (1): 7844. 21 December 2022

Cryo-electron tomography reveals structural insights into the membrane remodeling mode of dynamin-like EHD filaments.
Melo, A.A., Sprink, T., Noel, J.K., Vázquez-Sarandeses, E., van Hoorn, C., Mohd, S., Loerke, J., Spahn, C.M.T. and Daumke, O.
Nature Communications 13 (1): 7641. 10 December 2022

Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease.
Widjaja, A.A., Viswanathan, S., Shekeran, S.G., Adami, E., Lim, W.W., Chothani, S., Tan, J., Goh, J.W.T., Chen, H.M., Lim, S.Y., Boustany-Kari, C.M., Hawkins, J., Petretto, E., Hübner, N., Schafer, S., Coffman, T.M. and Cook, S.A.
Nature Communications 13 (1): 7497. 5 December 2022

Cell type diversity in a developing octopus brain.
Styfhals, R., Zolotarov, G., Hulselmans, G., Spanier, K.I., Poovathingal, S., Elagoz, A.M., De Winter, S., Deryckere, A., Rajewsky, N., Ponte, G., Fiorito, G., Aerts, S. and Seuntjens, E.
Nature Communications 13 (1): 7392. 30 November 2022

Quadruple gene-engineered natural killer cells enable multi-antigen targeting for durable antitumor activity against multiple myeloma.
Cichocki, F., Bjordahl, R., Goodridge, J.P., Mahmood, S., Gaidarova, S., Abujarour, R., Davis, Z.B., Merino, A., Tuininga, K., Wang, H., Kumar, A., Groff, B., Witty, A., Bonello, G., Huffman, J., Dailey, T., Lee, T.T., Malmberg, K.J., Walcheck, B., Höpken, U., Rehm, A., Valamehr, B. and Miller, J.S.
Nature Communications 13 (1): 7341. 29 November 2022

DNA methylation-based classification of sinonasal tumors.
Jurmeister, P., Glöß, S., Roller, R., Leitheiser, M., Schmid, S., Mochmann, L.H., Payá Capilla, E., Fritz, R., Dittmayer, C., Friedrich, C., Thieme, A., Keyl, P., Jarosch, A., Schallenberg, S., Bläker, H., Hoffmann, I., Vollbrecht, C., Lehmann, A., Hummel, M., Heim, D., Haji, M., Harter, P., Englert, B., Frank, S., Hench, J., Paulus, W., Hasselblatt, M., Hartmann, W., Dohmen, H., Keber, U., Jank, P., Denkert, C., Stadelmann, C., Bremmer, F., Richter, A., Wefers, A., Ribbat-Idel, J., Perner, S., Idel, C., Chiariotti, L., Della Monica, R., Marinelli, A., Schüller, U., Bockmayr, M., Liu, J., Lund, V.J., Forster, M., Lechner, M., Lorenzo-Guerra, S.L., Hermsen, M., Johann, P.D., Agaimy, A., Seegerer, P., Koch, A., Heppner, F., Pfister, S.M., Jones, D.T.W., Sill, M., von Deimling, A., Snuderl, M., Müller, K.R., Forgó, E., Howitt, B.E., Mertins, P., Klauschen, F. and Capper, D.
Nature Communications 13 (1): 7148. 28 November 2022

Differential compartmentalization of myeloid cell phenotypes and responses towards the CNS in Alzheimer's disease.
Fernández Zapata, C., Giacomello, G., Spruth, E.J., Middeldorp, J., Gallaccio, G., Dehlinger, A., Dames, C., Leman, J.K.H., van Dijk, R.E., Meisel, A., Schlickeiser, S., Kunkel, D., Hol, E.M., Paul, F., Parr, M.K., Priller, J. and Böttcher, C.
Nature Communications 13 (1): 7210. 23 November 2022

pTINCR microprotein promotes epithelial differentiation and suppresses tumor growth through CDC42 SUMOylation and activation.
Boix, O., Martinez, M., Vidal, S., Giménez-Alejandre, M., Palenzuela, L., Lorenzo-Sanz, L., Quevedo, L., Moscoso, O., Ruiz-Orera, J., Ximénez-Embún, P., Ciriaco, N., Nuciforo, P., Stephan-Otto Attolini, C., Albà, M.M., Muñoz, J., Tian, T.V., Varela, I., Vivancos, A., Ramón Y Cajal, S., Muñoz, P., Rivas, C. and Abad, M.
Nature Communications 13 (1): 6840. 11 November 2022

Molecular identity of proprioceptor subtypes innervating different muscle groups in mice.
Dietrich, S., Company, C., Song, K., Lowenstein, E.D., Riedel, L., Birchmeier, C., Gargiulo, G. and Zampieri, N.
Nature Communications 13 (1): 6867. 11 November 2022

Epithelial coxsackievirus adenovirus receptor promotes house dust mite-induced lung inflammation.
Ortiz-Zapater, E., Bagley, D.C., Hernandez, V.L., Roberts, L.B., Maguire, T.J.A., Voss, F., Mertins, P., Kirchner, M., Peset-Martin, I., Woszczek, G., Rosenblatt, J., Gotthardt, M., Santis, G. and Parsons, M.
Nature Communications 13 (1): 6407. 27 October 2022

Identifying interpretable gene-biomarker associations with functionally informed kernel-based tests in 190,000 exomes.
Monti, R., Rautenstrauch, P., Ghanbari, M., James, A.R., Kirchler, M., Ohler, U., Konigorski, S. and Lippert, C.
Nature Communications 13 (1): 5332. 10 September 2022

Mapping autophagosome contents identifies interleukin-7 receptor-α as a key cargo modulating CD4+ T cell proliferation.
Zhou, D., Borsa, M., Puleston, D.J., Zellner, S., Capera, J., Sanderson, S., Schifferer, M., Hester, S.S., Ge, X., Fischer, R., Jostins, L., Behrends, C., Alsaleh, G. and Simon, A.K.
Nature Communications 13 (1): 5174. 2 September 2022

A prospective observational study of post-COVID-19 chronic fatigue syndrome following the first pandemic wave in Germany and biomarkers associated with symptom severity.
Kedor, C., Freitag, H., Meyer-Arndt, L., Wittke, K., Hanitsch, L.G., Zoller, T., Steinbeis, F., Haffke, M., Rudolf, G., Heidecker, B., Bobbert, T., Spranger, J., Volk, H.D., Skurk, C., Konietschke, F., Paul, F., Behrends, U., Bellmann-Strobl, J. and Scheibenbogen, C.
Nature Communications 13 (1): 5104. 30 August 2022

Unified classification and risk-stratification in Acute Myeloid Leukemia.
Tazi, Y., Arango-Ossa, J.E., Zhou, Y., Bernard, E., Thomas, I., Gilkes, A., Freeman, S., Pradat, Y., Johnson, S.J., Hills, R., Dillon, R., Levine, M.F., Leongamornlert, D., Butler, A., Ganser, A., Bullinger, L., Döhner, K., Ottmann, O., Adams, R., Döhner, H., Campbell, P.J., Burnett, A.K., Dennis, M., Russell, N.H., Devlin, S.M., Huntly, B.J.P. and Papaemmanuil, E.
Nature Communications 13 (1): 4622. 8 August 2022

Pregnancy-induced maternal microchimerism shapes neurodevelopment and behavior in mice.
Schepanski, S., Chini, M., Sternemann, V., Urbschat, C., Thiele, K., Sun, T., Zhao, Y., Poburski, M., Woestemeier, A., Thieme, M.T., Zazara, D.E., Alawi, M., Fischer, N., Heeren, J., Vladimirov, N., Woehler, A., Puelles, V.G., Bonn, S., Gagliani, N., Hanganu-Opatz, I.L. and Arck, P.C.
Nature Communications 13 (1): 4571. 5 August 2022

Therapeutic targeting of ATR in alveolar rhabdomyosarcoma.
Dorado Garcia, H., Pusch, F., Bei, Y., von Stebut, J., Ibáñez, G., Guillan, K., Imami, K., Gürgen, D., Rolff, J., Helmsauer, K., Meyer-Liesener, S., Timme, N., Bardinet, V., Chamorro González, R., MacArthur, I.C., Chen, C.Y., Schulz, J., Wengner, A.M., Furth, C., Lala, B., Eggert, A., Seifert, G., Hundsoerfer, P., Kirchner, M., Mertins, P., Selbach, M., Lissat, A., Dubois, F., Horst, D., Schulte, J.H., Spuler, S., You, D., Dela Cruz, F., Kung, A.L., Haase, K., Di Virgilio, M., Scheer, M., Ortiz, M.V. and Henssen, A.G.
Nature Communications 13 (1): 4297. 25 July 2022

Loop-extrusion and polymer phase-separation can co-exist at the single-molecule level to shape chromatin folding.
Conte, M., Irani, E., Chiariello, A.M., Abraham, A., Bianco, S., Esposito, A. and Nicodemi, M.
Nature Communications 13 (1): 4070. 13 July 2022

Temperature elevations can induce switches to homoclinic action potentials that alter neural encoding and synchronization.
Hesse, J., Schleimer, J.H., Maier, N., Schmitz, D. and Schreiber, S.
Nature Communications 13 (1): 3934. 8 July 2022

Mafa-dependent GABAergic activity promotes mouse neonatal apneas.
Lecoin, L., Dempsey, B., Garancher, A., Bourane, S., Ruffault, P.L., Morin-Surun, M.P., Rocques, N., Goulding, M., Eychène, A., Pouponnot, C., Fortin, G. and Champagnat, J.
Nature Communications 13 (1): 3284. 7 June 2022

Mechanical forces couple bone matrix mineralization with inhibition of angiogenesis to limit adolescent bone growth.
Dzamukova, M., Brunner, T.M., Miotla-Zarebska, J., Heinrich, F., Brylka, L., Mashreghi, M.F., Kusumbe, A., Kühn, R., Schinke, T., Vincent, T.L.. and Löhning, M.
Nature Communications 13 (1): 3059. 1 June 2022

Serotonin limits generation of chromaffin cells during adrenal organ development.
Kameneva, P., Melnikova, V.I., Kastriti, M.E., Kurtova, A., Kryukov, E., Murtazina, A., Faure, L., Poverennaya, I., Artemov, A.V., Kalinina, T.S., Kudryashov, N.V., Bader, M., Skoda, J., Chlapek, P., Curylova, L., Sourada, L., Neradil, J., Tesarova, M., Pasqualetti, M., Gaspar, P., Yakushov, V.D., Sheftel, B.I., Zikmund, T., Kaiser, J., Fried, K., Alenina, N., Voronezhskaya, E.E. and Adameyko, I.
Nature Communications 13 (1): 2901. 25 May 2022

HDLBP binds ER-targeted mRNAs by multivalent interactions to promote protein synthesis of transmembrane and secreted proteins.
Zinnall, U., Milek, M., Minia, I., Vieira-Vieira, C.H., Müller, S., Mastrobuoni, G., Hazapis, O.G., Del Giudice, S., Schwefel, D., Bley, N., Voigt, F., Chao, J.A., Kempa, S., Hüttelmaier, S., Selbach, M. and Landthaler, M.
Nature Communications 13 (1): 2727. 18 May 2022

The genomic and transcriptional landscape of primary central nervous system lymphoma.
Radke, J., Ishaque, N., Koll, R., Gu, Z., Schumann, E., Sieverling, L., Uhrig, S., Hübschmann, D., Toprak, U.H., López, C., Hostench, X.P., Borgoni, S., Juraeva, D., Pritsch, F., Paramasivam, N., Balasubramanian, G.P., Schlesner, M., Sahay, S., Weniger, M., Pehl, D., Radbruch, H., Osterloh, A., Korfel, A., Misch, M., Onken, J., Faust, K., Vajkoczy, P., Moskopp, D., Wang, Y., Jödicke, A., Trümper, L., Anagnostopoulos, I., Lenze, D., Küppers, R., Hummel, M., Schmitt, C.A., Wiestler, O.D., Wolf, S., Unterberg, A., Eils, R., Herold-Mende, C., Brors, B., Siebert, R., Wiemann, S. and Heppner, F.L.
Nature Communications 13 (1): 2558. 10 May 2022

USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer.
Nelson, J.K., Thin, M.Z., Evan, T., Howell, S., Wu, M., Almeida, B., Legrave, N., Koenis, D. S., Koifman, G., Sugimoto, Y., Llorian Sopena, M., MacRae, J., Nye, E., Howell, M., Snijders, A.P., Prachalias, A., Zen, Y., Sarker, D. and Behrens, A.
Nature Communications 13 (1): 2070. 19 April 2022

BMP feed-forward loop promotes terminal differentiation in gastric glands and is interrupted by H. pylori-driven inflammation.
Kapalczynska, M., Lin, M., Maertzdorf, J., Heuberger, J., Muellerke, S., Zuo, X., Vidal, R., Shureiqi, I., Fischer, A.S., Sauer, S., Berger, H., Kidess, E., Mollenkopf, H.J., Tacke, F., Meyer, T.F. and Sigal, M.
Nature Communications 13 (1): 1577. 24 March 2022

The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD.
Günes Günsel, G., Conlon, T.M., Jeridi, A., Kim, R., Ertüz, Z., Lang, N.J., Ansari, M., Novikova, M., Jiang, D., Strunz, M., Gaianova, M., Hollauer, C., Gabriel, C., Angelidis, I., Doll, S., Pestoni, J.C., Edelmann, S.L., Kohlhepp, M.S., Guillot, A., Bassler, K., Van Eeckhoutte, H.P., Kayalar, Ö., Konyalilar, N., Kanashova, T., Rodius, S., Ballester-López, C., Genes Robles, C.M., Smirnova, N., Rehberg, M., Agarwal, C., Krikki, I., Piavaux, B., Verleden, S.E., Vanaudenaerde, B., Königshoff, M., Dittmar, G., Bracke, K.R., Schultze, J.L., Watz, H., Eickelberg, O., Stoeger, T., Burgstaller, G., Tacke, F., Heissmeyer, V., Rinkevich, Y., Bayram, H., Schiller, H.B., Conrad, M., Schneider, R. and Yildirim, A.Ö.
Nature Communications 13 (1): 1303. 14 March 2022

Autoantibodies targeting GPCRs and RAS-related molecules associate with COVID-19 severity.
Cabral-Marques, O., Halpert, G., Schimke, L.F., Ostrinski, Y., Vojdani, A., Baiocchi, G.C., Freire, P.P., Filgueiras, I.S., Zyskind, I., Lattin, M.T., Tran, F., Schreiber, S., Marques, A.H.C., Plaça, D.R., Fonseca, D.L.M., Humrich, J.Y., Müller, A., Giil, L.M., Graßhoff, H., Schumann, A., Hackel, A., Junker, J., Meyer, C., Ochs, H.D., Lavi, Y.B., Scheibenbogen, C., Dechend, R., Jurisica, I., Schulze-Forster, K., Silverberg, J.I., Amital, H., Zimmerman, J., Heidecke, H., Rosenberg, A.Z., Riemekasten, G. and Shoenfeld, Y.
Nature Communications 13 (1): 1220. 9 March 2022

Proteomic profiling reveals CDK6 upregulation as a targetable resistance mechanism for lenalidomide in multiple myeloma.
Ng, Y.L.D., Ramberger, E., Bohl, S.R., Dolnik, A., Steinebach, C., Conrad, T., Müller, S., Popp, O., Kull, M., Haji, M., Gütschow, M., Döhner, H., Walther, W., Keller, U., Bullinger, L., Mertins, P. and Krönke, J.
Nature Communications 13 (1): 1009. 23 February 2022

Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection.
Pekayvaz, K., Leunig, A., Kaiser, R., Joppich, M., Brambs, S., Janjic, A., Popp, O., Nixdorf, D., Fumagalli, V., Schmidt, N., Polewka, V., Anjum, A., Knottenberg, V., Eivers, L., Wange, L.E., Gold, C., Kirchner, M., Muenchhoff, M., Hellmuth, J.C., Scherer, C., Rubio-Acero, R., Eser, T., Deák, F., Puchinger, K., Kuhl, N., Linder, A., Saar, K., Tomas, L., Schulz, C., Wieser, A., Enard, W., Kroidl, I., Geldmacher, C., von Bergwelt-Baildon, M., Keppler, O.T., Munschauer, M., Iannacone, M., Zimmer, R., Mertins, P., Hubner, N., Hoelscher, M., Massberg, S., Stark, K. and Nicolai, L.
Nature Communications 13 (1): 1018. 23 February 2022

Genetic alterations of the SUMO isopeptidase SENP6 drive lymphomagenesis and genetic instability in diffuse large B-cell lymphoma.
Schick, M., Zhang, L., Maurer, S., Maurer, H.C., Isaakaidis, K., Schneider, L., Patra, U., Schunck, K., Rohleder, E., Hofstetter, J., Baluapuri, A., Scherger, A.K., Slotta-Huspenina, J., Hettler, F., Weber, J., Engleitner, T., Maresch, R., Slawska, J., Lewis, R., Istvanffy, R., Habringer, S., Steiger, K., Baiker, A., Oostendorp, R.A.J., Miething, C., Lenhof, H.P., Bassermann, F., Chapuy, B., Wirth, M., Wolf, E., Rad, R., Müller, S. and Keller, U.
Nature Communications 13 (1): 281. 12 January 2022

Skeletal muscle derived Musclin protects the heart during pathological overload.
Szaroszyk, M., Kattih, B., Martin-Garrido, A., Trogisch, F.A., Dittrich, G.M., Grund, A., Abouissa, A., Derlin, K., Meier, M., Holler, T., Korf-Klingebiel, M., Völker, K., Macedo, T.G., Tortola, C.P., Boschmann, M., Huang, N., Froese, N., Zwadlo, C., Malek Mohammadi, M., Luo, X., Wagner, M., Cordero, J., Geffers, R., Batkai, S., Thum, T., Bork, N., Nikolaev, V.O., Müller, O.J., Katus, H.A., El-Armouche, A., Kraft, T., Springer, J., Dobreva, G., Wollert, K.C., Fielitz, J., von Haehling, S., Kuhn, M., Bauersachs, J. and Heineke, J.
Nature Communications 13 (1): 149. 10 January 2022

2021

RNF219 attenuates global mRNA decay through inhibition of CCR4-NOT complex-mediated deadenylation.
Poetz, F., Corbo, J., Levdansky, Y., Spiegelhalter, A., Lindner, D., Magg, V., Lebedeva, S., Schweiggert, J., Schott, J., Valkov, E. and Stoecklin, G.
Nature Communications 12 (1): 7175. 9 December 2021

Spatial and temporal intratumour heterogeneity has potential consequences for single biopsy-based neuroblastoma treatment decisions.
Schmelz, K., Toedling, J., Huska, M., Cwikla, M.C., Kruetzfeldt, L.M., Proba, J., Ambros, P.F., Ambros, I.M., Boral, S., Lodrini, M., Chen, C.Y., Burkert, M., Guergen, D., Szymansky, A., Astrahantseff, K., Kuenkele, A., Haase, K., Fischer, M., Deubzer, H.E., Hertwig, F., Hundsdoerfer, P., Henssen, A.G., Schwarz, R.F., Schulte, J.H. and Eggert, A.
Nature Communications 12 (1): 6804. 23 November 2021

Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities.
Kruse, T., Benz, C., Garvanska, D.H., Lindqvist, R., Mihalic, F., Coscia, F., Inturi, R., Sayadi, A., Simonetti, L., Nilsson, E., Ali, M., Kliche, J., Moliner Morro, A., Mund, A., Andersson, E., McInerney, G., Mann, M., Jemth, P., Davey, N.E., Överby, A.K., Nilsson, J. and Ivarsson, Y.
Nature Communications 12 (1): 6761. 19 November 2021

Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors.
Geusz, R.J., Wang, A., Lam, D.K., Vinckier, N.K., Alysandratos, K.D., Roberts, D.A., Wang, J., Kefalopoulou, S., Ramirez, A., Qiu, Y., Chiou, J., Gaulton, K.J., Ren, B., Kotton, D.N. and Sander, M.
Nature Communications 12 (1): 6636. 17 November 2021

Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4.
Grosche, S., Marenholz, I., Esparza-Gordillo, J., Arnau-Soler, A., Pairo-Castineira, E., Rüschendorf, F., Ahluwalia, T.S., Almqvist, C., Arnold, A., Baurecht, H., Bisgaard, H., Bønnelykke, K., Brown, S.J., Bustamante, M., Curtin, J.A., Custovic, A., Dharmage, S.C., Esplugues, A., Falchi, M., Fernandez-Orth, D., Ferreira, M.A.R., Franke, A., Gerdes, S., Gieger, C., Hakonarson, H., Holt, P.G., Homuth, G., Hubner, N., Hysi, P.G., Jarvelin, M.R., Karlsson, R., Koppelman, G.H., Lau, S., Lutz, M., Magnusson, P.K.E., Marks, G.B., Müller-Nurasyid, M., Nöthen, M.M., Paternoster, L., Pennell, C.E., Peters, A., Rawlik, K., Robertson, C.F., Rodriguez, E., Sebert, S., Simpson, A., Sleiman, P.M.A., Standl, M., Stölzl, D., Strauch, K., Szwajda, A., Tenesa, A., Thompson, P.J., Ullemar, V., Visconti, A., Vonk, J.M., Wang, C.A., Weidinger, S., Wielscher, M., Sargent, C.L., Xu, C.J. and Lee, Y.A.
Nature Communications 12 (1): 6618. 16 November 2021

Lysine acetylation regulates the interaction between proteins and membranes.
Okada, A.K., Teranishi, K., Ambroso, M.R., Isas, J.M., Vazquez-Sarandeses, E., Lee, J.Y., Melo, A.A., Pandey, P., Merken, D., Berndt, L., Lammers, M., Daumke, O., Chang, K., Haworth, I.S. and Langen, R.
Nature Communications 12 (1): 6466. 9 November 2021

A medullary centre for lapping in mice.
Dempsey, B., Sungeelee, S., Bokiniec, P., Chettouh, Z., Diem, S., Autran, S., Harrell, E.R., Poulet, J.F.A., Birchmeier, C., Carey, H., Genovesio, A., McMullan, S., Goridis, C., Fortin, G. and Brunet, J.F.
Nature Communications 12 : 6307. 2 November 2021

PHF3 regulates neuronal gene expression through the Pol II CTD reader domain SPOC.
Appel, L.M., Franke, V., Bruno, M., Grishkovskaya, I., Kasiliauskaite, A., Kaufmann, T., Schoeberl, U.E., Puchinger, M.G., Kostrhon, S., Ebenwaldner, C., Sebesta, M., Beltzung, E., Mechtler, K., Lin, G., Vlasova, A., Leeb, M., Pavri, R., Stark, A., Akalin, A., Stefl, R., Bernecky, C., Djinovic-Carugo, K. and Slade, D.
Nature Communications 12 (1): 6078. 19 October 2021

Super-enhancer-based identification of a BATF3/IL-2R-module reveals vulnerabilities in anaplastic large cell lymphoma.
Liang, H.C., Costanza, M., Prutsch, N., Zimmerman, M.W., Gurnhofer, E., Montes-Mojarro, I.A., Abraham, B.J., Prokoph, N., Stoiber, S., Tangermann, S., Lobello, C., Oppelt, J., Anagnostopoulos, I., Hielscher, T., Pervez, S., Klapper, W., Zammarchi, F., Silva, D.A., Garcia, K.C., Baker, D., Janz, M., Schleussner, N., Fend, F., Pospíšilová, Š., Janiková, A., Wallwitz, J., Stoiber, D., Simonitsch-Klupp, I., Cerroni, L., Pileri, S., de Leval, L., Sibon, D., Fataccioli, V., Gaulard, P., Assaf, C., Knörr, F., Damm-Welk, C., Woessmann, W., Turner, S.D., Look, A.T., Mathas, S., Kenner, L. and Merkel, O.
Nature Communications 12 (1): 5577. 22 September 2021

MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I.
Brägelmann, J., Lorenz, C., Borchmann, S., Nishii, K., Wegner, J., Meder, L., Ostendorp, J., Ast, D.F., Heimsoeth, A., Nakasuka, T., Hirabae, A., Okawa, S., Dammert, M.A., Plenker, D., Klein, S., Lohneis, P., Gu, J., Godfrey, L.K., Forster, J., Trajkovic-Arsic, M., Zillinger, T., Haarmann, M., Quaas, A., Lennartz, S., Schmiel, M., D'Rozario, J., Thomas, E.S., Li, H., Schmitt, C.A., George, J., Thomas, R.K., von Karstedt, S., Hartmann, G., Büttner, R., Ullrich, R.T., Siveke, J.T., Ohashi, K., Schlee, M. and Sos, M.L.
Nature Communications 12 (1): 5505. 17 September 2021

Multi-platform profiling characterizes molecular subgroups and resistance networks in chronic lymphocytic leukemia.
Bloehdorn, J., Braun, A., Taylor-Weiner, A., Jebaraj, B.M.C., Robrecht, S., Krzykalla, J., Pan, H., Giza, A., Akylzhanova, G., Holzmann, K., Scheffold, A., Johnston, H.E., Yeh, R.F., Klymenko, T., Tausch, E., Eichhorst, B., Bullinger, L., Fischer, K., Weisser, M., Robak, T., Schneider, C., Gribben, J., Dahal, L.N., Carter, M.J., Elemento, O., Landau, D.A., Neuberg, D.S., Cragg, M.S., Benner, A., Hallek, M., Wu, C.J., Döhner, H., Stilgenbauer, S. and Mertens, D.
Nature Communications 12 (1): 5395. 13 September 2021

CTCF knockout in zebrafish induces alterations in regulatory landscapes and developmental gene expression.
Franke, M., De la Calle-Mustienes, E., Neto, A., Almuedo-Castillo, M., Irastorza-Azcarate, I., Acemel, R.D., Tena, J.J., Santos-Pereira, J.M. and Gómez-Skarmeta, J.L.
Nature Communications 12 (1): 5415. 13 September 2021

Locus specific epigenetic modalities of random allelic expression imbalance.
Marion-Poll, L., Forêt, B., Zielinski, D., Massip, F., Attia, M., Carter, A.C., Syx, L., Chang, H.Y., Gendrel, A.V. and Heard, E.
Nature Communications 12 (1): 5330. 9 September 2021

Epigenetic control of melanoma cell invasiveness by the stem cell factor SALL4.
Diener, J., Baggiolini, A., Pernebrink, M., Dalcher, D., Lerra, L., Cheng, P.F., Varum, S., Häusel, J., Stierli, S., Treier, M., Studer, L., Basler, K., Levesque, M.P., Dummer, R., Santoro, R., Cantù, C. and Sommer, L.
Nature Communications 12 (1): 5056. 20 August 2021

A simple pressure-assisted method for MicroED specimen preparation.
Zhao, J., Xu, H., Lebrette, H., Carroni, M., Taberman, H., Högbom, M. and Zou, X.
Nature Communications 12 (1): 5036. 19 August 2021

Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19.
Nouailles, G., Wyler, E., Pennitz, P., Postmus, D., Vladimirova, D., Kazmierski, J., Pott, F., Dietert, K., Muelleder, M., Farztdinov, V., Obermayer, B., Wienhold, S.M., Andreotti, S., Hoefler, T., Sawitzki, B., Drosten, C., Sander, L.E., Suttorp, N., Ralser, M., Beule, D., Gruber, A.D., Goffinet, C., Landthaler, M., Trimpert, J. and Witzenrath, M.
Nature Communications 12 (1): 4869. 11 August 2021

Place fields of single spikes in hippocampus involve Kcnq3 channel-dependent entrainment of complex spike bursts.
Gao, X., Bender, F., Soh, H., Chen, C., Altafi, M., Schütze, S., Heidenreich, M., Gorbati, M., Corbu, M.A., Carus-Cadavieco, M., Korotkova, T., Tzingounis, A.V., Jentsch, T.J. and Ponomarenko, A.
Nature Communications 12 (1): 4801. 10 August 2021

SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6 endonucleolytic activity.
Boehm, V., Kueckelmann, S., Gerbracht, J.V., Kallabis, S., Britto-Borges, T., Altmüller, J., Krüger, M., Dieterich, C. and Gehring, N.H.
Nature Communications 12 (1): 3965. 25 June 2021

Post-myocardial infarction heart failure dysregulates the bone vascular niche.
Hoffmann, J., Luxán, G., Abplanalp, W.T., Glaser, S.F., Rasper, T., Fischer, A., Muhly-Reinholz, M., Potente, M., Assmus, B., John, D., Zeiher, A.M. and Dimmeler, S.
Nature Communications 12 (1): 3964. 25 June 2021

SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals.
Gassen, N.C., Papies, J., Bajaj, T., Emanuel, J., Dethloff, F., Chua, R.L., Trimpert, J., Heinemann, N., Niemeyer, C., Weege, F., Hönzke, K., Aschman, T., Heinz, D.E., Weckmann, K., Ebert, T., Zellner, A., Lennarz, M., Wyler, E., Schroeder, S., Richter, A., Niemeyer, D., Hoffmann, K., Meyer, T.F., Heppner, F.L., Corman, V.M., Landthaler, M., Hocke, A.C., Morkel, M., Osterrieder, N., Conrad, C., Eils, R., Radbruch, H., Giavalisco, P., Drosten, C. and Müller, M.A.
Nature Communications 12 (1): 3818. 21 June 2021

Comprehensive micro-scaled proteome and phosphoproteome characterization of archived retrospective cancer repositories.
Friedrich, C., Schallenberg, S., Kirchner, M., Ziehm, M., Niquet, S., Haji, M., Beier, C., Neudecker, J., Klauschen, F. and Mertins, P.
Nature Communications 12 (1): 3576. 11 June 2021

Spatio-temporal mRNA tracking in the early zebrafish embryo.
Holler, K., Neuschulz, A., Drewe-Boß, P., Mintcheva, J., Spanjaard, B., Arsiè, R., Ohler, U., Landthaler, M. and Junker, J.P.
Nature Communications 12 : 3358. 7 June 2021

Common variants in Alzheimer's disease and risk stratification by polygenic risk scores.
de Rojas, I., Moreno-Grau, S., Tesi, N., Grenier-Boley, B., Andrade, V., Jansen, I.E., Pedersen, N.L., Stringa, N., Zettergren, A., Hernández, I., Montrreal, L., Antúnez, C., Antonell, A., Tankard, R.M., Bis, J.C., Sims, R., Bellenguez, C., Quintela, I., González-Perez, A., Calero, M., Franco-Macías, E., Macías, J., Blesa, R., Cervera-Carles, L., Menéndez-González, M., Frank-García, A., Royo, J.L., Moreno, F., Huerto Vilas, R., Baquero, M., Diez-Fairen, M., Lage, C., García-Madrona, S., García-González, P., Alarcón-Martín, E., Valero, S., Sotolongo-Grau, O., Ullgren, A., Naj, A.C., Lemstra, A.W., Benaque, A., Pérez-Cordón, A., Benussi, A., Rábano, A., Padovani, A., Squassina, A., de Mendonça, A., Arias Pastor, A., Kok, A.A.L., Meggy, A., Pastor, A.B., Espinosa, A., Corma-Gómez, A., Martín Montes, A., Sanabria, Á., DeStefano, A.L., Schneider, A., Haapasalo, A., Kinhult Ståhlbom, A., Tybjærg-Hansen, A., Hartmann, A.M., Spottke, A., Corbatón-Anchuelo, A., Rongve, A., Borroni, B., Arosio, B., Nacmias, B., Nordestgaard, B.G., Kunkle, B.W., Charbonnier, C., Abdelnour, C., Masullo, C., Martínez Rodríguez, C., Muñoz-Fernandez, C., Dufouil, C., Graff, C., Ferreira, C.B., Chillotti, C., Reynolds, C.A., Fenoglio, C., Van Broeckhoven, C., Clark, C., Pisanu, C., Satizabal, C.L., Holmes, C., Buiza-Rueda, D., Aarsland, D., Rujescu, D., Alcolea, D., Galimberti, D., Wallon, D., Seripa, D., Grünblatt, E., Dardiotis, E., Düzel, E., Scarpini, E., Conti, E., Rubino, E., Gelpi, E., Rodriguez-Rodriguez, E., Duron, E., Boerwinkle, E., Ferri, E., Tagliavini, F., Küçükali, F., Pasquier, F., Sanchez-Garcia, F., Mangialasche, F., Jessen, F., Nicolas, G., Selbæk, G., Ortega, G., Chêne, G., Hadjigeorgiou, G., Rossi, G., Spalletta, G., Giaccone, G., Grande, G., Binetti, G., Papenberg, G., Hampel, H., Bailly, H., Zetterberg, H., Soininen, H., Karlsson, I.K., Alvarez, I., Appollonio, I., Giegling, I., Skoog, I., Saltvedt, I., Rainero, I., Rosas Allende, I., Hort, J., Diehl-Schmid, J., Van Dongen, J., Vidal, J.S., Lehtisalo, J., Wiltfang, J., Thomassen, J.Q., Kornhuber, J., Haines, J.L., Vogelgsang, J., Pineda, J.A., Fortea, J., Popp, J., Deckert, J., Buerger, K., Morgan, K., Fließbach, K., Sleegers, K., Molina-Porcel, L., Kilander, L., Weinhold, L., Farrer, L.A., Wang, L.S., Kleineidam, L., Farotti, L., Parnetti, L., Tremolizzo, L., Hausner, L., Benussi, L., Froelich, L., Ikram, M.A., Deniz-Naranjo, M.C., Tsolaki, M., Rosende-Roca, M., Löwenmark, M., Hulsman, M., Spallazzi, M., Pericak-Vance, M.A., Esiri, M., Bernal Sánchez-Arjona, M., Dalmasso, M.C., Martínez-Larrad, M.T., Arcaro, M., Nöthen, M.M., Fernández-Fuertes, M., Dichgans, M., Ingelsson, M., Herrmann, M.J., Scherer, M., Vyhnalek, M., Kosmidis, M.H., Yannakoulia, M., Schmid, M., Ewers, M., Heneka, M.T., Wagner, M., Scamosci, M., Kivipelto, M., Hiltunen, M., Zulaica, M., Alegret, M., Fornage, M., Roberto, N., van Schoor, N.M., Seidu, N.M., Banaj, N., Armstrong, N.J., Scarmeas, N., Scherbaum, N., Goldhardt, O., Hanon, O., Peters, O., Skrobot, O.A., Quenez, O., Lerch, O., Bossù, P., Caffarra, P., Dionigi Rossi, P., Sakka, P., Mecocci, P., Hoffmann, P., Holmans, P.A., Fischer, P., Riederer, P., Yang, Q., Marshall, R., Kalaria, R.N., Mayeux, R., Vandenberghe, R., Cecchetti, R., Ghidoni, R., Frikke-Schmidt, R., Sorbi, S., Hägg, S., Engelborghs, S., Helisalmi, S., Botne Sando, S., Kern, S., Archetti, S., Boschi, S., Fostinelli, S., Gil, S., Mendoza, S., Mead, S., Ciccone, S., Djurovic, S., Heilmann-Heimbach, S., Riedel-Heller, S., Kuulasmaa, T., Del Ser, T., Lebouvier, T., Polak, T., Ngandu, T., Grimmer, T., Bessi, V., Escott-Price, V., Giedraitis, V., Deramecourt, Vi., Maier, W., Jian, X., Pijnenburg, Y.A.L., Kehoe, P.G., Garcia-Ribas, G., Sánchez-Juan, P., Pastor, P., Pérez-Tur, J., Piñol-Ripoll, G., Lopez de Munain, A., García-Alberca, J.M., Bullido, M.J., Álvarez, V., Lleó, A., Real, L.M., Mir, P., Medina, M., Scheltens, P., Holstege, H., Marquié, M., Sáez, M.E., Carracedo, Á., Amouyel, P., Schellenberg, G.D., Williams, J., Seshadri, S., van Duijn, C.M., Mather, K.A., Sánchez-Valle, R., Serrano-Ríos, M., Orellana, A., Tárraga, L., Blennow, K., Huisman, M., Andreassen, O.A., Posthuma, D., Clarimón, J., Boada, M., van der Flier, W.M., Ramirez, A., Lambert, J.C., van der Lee, S.J. and Ruiz, A.
Nature Communications 12 (1): 3417. 7 June 2021

Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network.
Grapotte, M., Saraswat, M., Bessière, C., Menichelli, C., Ramilowski, J.A., Severin, J., Hayashizaki, Y., Itoh, M., Tagami, M., Murata, M., Kojima-Ishiyama, M., Noma, S., Noguchi, S., Kasukawa, T., Hasegawa, A., Suzuki, H., Nishiyori-Sueki, H., Frith, M.C., Chatelain, C., Carninci, P., de Hoon, M.J.L., Wasserman, W.W., Bréhélin, L. and Lecellier, C.H.
Nature Communications 12 (1): 3297. 2 June 2021

EGFR-HIF1α signaling positively regulates the differentiation of IL-9 producing T helper cells.
Roy, S., Rizvi, Z.A., Clarke, A.J., Macdonald, F., Pandey, A., Zaiss, D.M.W., Simon, A.K. and Awasthi, A.
Nature Communications 12 (1): 3182. 1 June 2021

The splicing factor XAB2 interacts with ERCC1-XPF and XPG for R-loop processing.
Goulielmaki, E., Tsekrekou, M., Batsiotos, N., Ascensão-Ferreira, M., Ledaki, E., Stratigi, K., Chatzinikolaou, G., Topalis, P., Kosteas, T., Altmüller, J., Demmers, J.A., Barbosa-Morais, N.L. and Garinis, G.A.
Nature Communications 12 (1): 3153. 26 May 2021

Overarching control of autophagy and DNA damage response by CHD6 revealed by modeling a rare human pathology.
Kargapolova, Y., Rehimi, R., Kayserili, H., Brühl, J., Sofiadis, K., Zirkel, A., Palikyras, S., Mizi, A., Li, Y., Yigit, G., Hoischen, A., Frank, S., Russ, N., Trautwein, J., van Bon, B., Gilissen, C., Laugsch, M., Gusmao, E.G., Josipovic, N., Altmüller, J., Nürnberg, P., Längst, G., Kaiser, F.J., Watrin, E., Brunner, H., Rada-Iglesias, A., Kurian, L., Wollnik, B., Bouazoune, K. and Papantonis, A.
Nature Communications 12 (1): 3014. 21 May 2021

Asymmetric cell division shapes naive and virtual memory T-cell immunity during ageing.
Borsa, M., Barandun, N., Gräbnitz, F., Barnstorf, I., Baumann, N.S., Pallmer, K., Baumann, S., Stark, D., Balaz, M., Oetiker, N., Wagen, F., Wolfrum, C., Simon, A.K., Joller, N., Barral, Y., Spörri, R. and Oxenius, A.
Nature Communications 12 (1): 2715. 11 May 2021

Temporal analysis of T-cell receptor-imposed forces via quantitative single molecule FRET measurements.
Göhring, J., Kellner, F., Schrangl, L., Platzer, R., Klotzsch, E., Stockinger, H., Huppa, J.B. and Schütz, G.J.
Nature Communications 12 (1): 2502. 4 May 2021

Fasting alters the gut microbiome reducing blood pressure and body weight in metabolic syndrome patients.
Maifeld, A., Bartolomaeus, H., Löber, U., Avery, E.G., Steckhan, N., Markó, L., Wilck, N., Hamad, I., Šušnjar, U., Mähler, A., Hohmann, C., Chen, C.Y., Cramer, H., Dobos, G., Lesker, T.R., Strowig, T., Dechend, R., Bzdok, D., Kleinewietfeld, M., Michalsen, A., Müller, D.N. and Forslund, S.K.
Nature Communications 12 (1): 1970. 30 March 2021

Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome.
Inak, G., Rybak-Wolf, A., Lisowski, P., Pentimalli, T.M., Jüttner, R., Glažar, P., Uppal, K., Bottani, E., Brunetti, D., Secker, C., Zink, A., Meierhofer, D., Henke, M.T., Dey, M., Ciptasari, U., Mlody, B., Hahn, T., Berruezo-Llacuna, M., Karaiskos, N., Di Virgilio, M., Mayr, J.A., Wortmann, S.B., Priller, J., Gotthardt, M., Jones, D.P., Mayatepek, E., Stenzel, W., Diecke, S., Kühn, R., Wanker, E.E., Rajewsky, N., Schuelke, M. and Prigione, A.
Nature Communications 12 (1): 1929. 26 March 2021

Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction.
Schiattarella, G.G., Altamirano, F., Kim, S.Y., Tong, D., Ferdous, A., Piristine, H., Dasgupta, S., Wang, X., French, K.M., Villalobos, E., Spurgin, S.B., Waldman, M., Jiang, N., May, H.I., Hill, T.M., Luo, Y., Yoo, H., Zaha, V.G., Lavandero, S., Gillette, T.G. and Hill, J.A.
Nature Communications 12 (1): 1684. 16 March 2021

Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics.
Velten, L., Story, B.A., Hernández-Malmierca, P., Raffel, S., Leonce, D.R., Milbank, J., Paulsen, M., Demir, A., Szu-Tu, C., Frömel, R., Lutz, C., Nowak, D., Jann, J.C., Pabst, C., Boch, T., Hofmann, W.K., Müller-Tidow, C., Trumpp, A., Haas, S. and Steinmetz, L.M.
Nature Communications 12 (1): 1366. 1 March 2021

Oscillations of Delta-like1 regulate the balance between differentiation and maintenance of muscle stem cells.
Zhang, Y., Lahmann, I., Baum, K., Shimojo, H., Mourikis, P., Wolf, J., Kageyama, R. and Birchmeier, C.
Nature Communications 12 (1): 1318. 26 February 2021

Alternative lengthening of telomeres in childhood neuroblastoma from genome to proteome.
Hartlieb, S.A., Sieverling, L., Nadler-Holly, M., Ziehm, M., Toprak, U.H., Herrmann, C., Ishaque, N., Okonechnikov, K., Gartlgruber, M., Park, Y.G., Wecht, E.M., Savelyeva, L., Henrich, K.O., Rosswog, C., Fischer, M., Hero, B., Jones, D.T.W., Pfaff, E., Witt, O., Pfister, S.M., Volckmann, Ri., Koster, J., Kiesel, K., Rippe, K., Taschner-Mandl, S., Ambros, P., Brors, B., Selbach, M., Feuerbach, L. and Westermann, F.
Nature Communications 12 (1): 1269. 24 February 2021

Asymmetric opening of the homopentameric 5-HT(3A) serotonin receptor in lipid bilayers.
Zhang, Y., Dijkman, P.M., Zou, R., Zandl-Lang, M., Sanchez, R.M., Eckhardt-Strelau, L., Köfeler, H., Vogel, H., Yuan, S. and Kudryashev, M.
Nature Communications 12 (1): 1074. 16 February 2021

Genomic aberrations after short-term exposure to colibactin-producing E. coli transform primary colon epithelial cells.
Iftekhar, A., Berger, H., Bouznad, N., Heuberger, J., Boccellato, F., Dobrindt, U., Hermeking, H., Sigal, M. and Meyer, T.F.
Nature Communications 12 (1): 1003. 12 February 2021

Uncovering de novo gene birth in yeast using deep transcriptomics.
Blevins, W.R., Ruiz-Orera, J., Messeguer, X., Blasco-Moreno, B., Villanueva-Cañas, J.L., Espinar, L., Díez, J., Carey, L.B. and Albà, M.M.
Nature Communications 12 (1): 604. 27 January 2021

Endophilin A2 deficiency protects rodents from autoimmune arthritis by modulating T cell activation.
Norin, U., Rintisch, C., Meng, L., Forster, F., Ekman, D., Tuncel, J., Klocke, K., Bäcklund, J., Yang, M., Bonner, M.Y, Lahore, G.F., James, J., Shchetynsky, K., Bergquist, M., Gjertsson, I., Hubner, N., Bäckdahl, L. and Holmdahl, R.
Nature Communications 12 (1): 610. 27 January 2021

Age-related and disease locus-specific mechanisms contribute to early remodelling of chromatin structure in Huntington's disease mice.
Alcalá-Vida, R., Seguin, J., Lotz, C., Molitor, A.M., Irastorza-Azcarate, I., Awada, A., Karasu, N., Bombardier, A., Cosquer, B., Skarmeta, J.L.G., Cassel, J.C., Boutillier, A.L., Sexton, T. and Merienne, K.
Nature Communications 12 (1): 364. 13 January 2021

CXCR5 CAR-T cells simultaneously target B cell non-Hodgkin's lymphoma and tumor-supportive follicular T helper cells.
Bunse, M., Pfeilschifter, J., Bluhm, J., Zschummel, M., Joedicke, J.J., Wirges, A., Stark, H., Kretschmer, V., Chmielewski, M., Uckert, W., Abken, H., Westermann, J., Rehm, A. and Höpken, U.E.
Nature Communications 12 (1): 240. 11 January 2021

2020

The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness.
Grinat, J., Heuberger, J., Vidal, R., Goveas, N., Kosel, F., Berenguer-Llergo, A., Kranz, A., Wulf-Goldenberg, A., Behrens, D., Melcher, B., Sauer, S., Vieth, M., Batlle, E., Stewart, A. and Birchmeier, W.
Nature Communications 11 (1): 6422. 21 December 2020

Single-nucleus transcriptomics reveals functional compartmentalization in syncytial skeletal muscle cells.
Kim, M., Franke, V., Brandt, B., Lowenstein, E.D., Schöwel, V., Spuler, S., Akalin, A. and Birchmeier, C.
Nature Communications 11 : 6375. 11 December 2020

Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology.
Molinaro, A., Bel Lassen, P., Henricsson, M., Wu, H., Adriouch, S., Belda, E., Chakaroun, R., Nielsen, T., Bergh, P.O., Rouault, C., André, S., Marquet, F., Andreelli, F., Salem, J.E., Assmann, K., Bastard, J.P., Forslund, S., Le Chatelier, E., Falony, G., Pons, N., Prifti, E., Quinquis, B., Roume, H., Vieira-Silva, S., Hansen, T.H., Pedersen, H.K., Lewinter, C., Sønderskov, N.B., Køber, L., Vestergaard, H., Hansen, T., Zucker, J.D., Galan, P., Dumas, M.E., Raes, J., Oppert, J.M., Letunic, I., Nielsen, J., Bork, P., Ehrlich, S.D., Stumvoll, M., Pedersen, O., Aron-Wisnewsky, J., Clément, K. and Bäckhed, F.
Nature Communications 11 (1): 5881. 18 November 2020

Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma.
Helmsauer, K., Valieva, M.E., Ali, S., Chamorro Gonzalez, R., Schöpflin, R., Röefzaad, C., Bei, Y., Dorado Garcia, H., Rodriguez-Fos, E., Puiggròs, M., Kasack, K., Haase, K., Keskeny, C., Chen, C.Y., Kuschel, L.P., Euskirchen, P., Heinrich, V., Robson, M.I., Rosswog, C., Toedling, J., Szymansky, A., Hertwig, F., Fischer, M., Torrents, D., Eggert, A., Schulte, J.H., Mundlos, S., Henssen, A.G. and Koche, R.P.
Nature Communications 11 (1): 5823. 16 November 2020

Spatially and cell-type resolved quantitative proteomic atlas of healthy human skin.
Dyring-Andersen, B., Løvendorf, M.B., Coscia, F., Santos, A., Møller, L.B.P., Colaço, A.R., Niu, L., Bzorek, M., Doll, S., Andersen, J.L., Clark, R.A., Skov, L., Teunissen, M.B.M. and Mann, M.
Nature Communications 11 (1): 5587. 5 November 2020

Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits.
Quach, B.C., Bray, M.J., Gaddis, N.C., Liu, M., Palviainen, T., Minica, C.C., Zellers, S., Sherva, R., Aliev, F., Nothnagel, M., Young, K.A., Marks, J.A., Young, H., Carnes, M.U., Guo, Y., Waldrop, A., Sey, N..A., Landi, M.T., McNeil, D.W., Drichel, D., Farrer, L.A., Markunas, C.A., Vink, J.M., Hottenga, J.J., Iacono, W.G., Kranzler, H.R., Saccone, N.L., Neale, M.C., Madden, P., Rietschel, M., Marazita, M.L., McGue, M., Won, H., Winterer, G., Grucza, R., Dick, D.M., Gelernter, J., Caporaso, N.E., Baker, T.B., Boomsma, D.I., Kaprio, J., Hokanson, J.E., Vrieze, S., Bierut, L.J., Johnson, E.O. and Hancock, D.B.
Nature Communications 11 (1): 5562. 3 November 2020

Divergent architecture of the heterotrimeric NatC complex explains N-terminal acetylation of cognate substrates.
Grunwald, S., Hopf, L.V.M., Bock-Bierbaum, T., Lally, C.C.M., Spahn, C.M.T. and Daumke, O.
Nature Communications 11 (1): 5506. 2 November 2020

YAP and TAZ protect against white adipocyte cell death during obesity.
Wang, L., Wang, S.P., Shi, Y., Li, R., Günther, S., Ong, Y.T., Potente, M., Yuan, Z., Liu, E. and Offermanns, S.
Nature Communications 11 (1): 5455. 28 October 2020

Globally altered epigenetic landscape and delayed osteogenic differentiation in H3.3-G34W-mutant giant cell tumor of bone.
Lutsik, P., Baude, A., Mancarella, D., Öz, S., Kühn, A., Toth, R., Hey, J., Toprak, U.H., Lim, J., Nguyen, V.H., Jiang, C., Mayakonda, A., Hartmann, M., Rosemann, F., Breuer, K., Vonficht, D., Grünschläger, F., Lee, S., Schuhmacher, M.K., Kusevic, D., Jauch, A., Weichenhan, D., Zustin, J., Schlesner, M., Haas, S., Park, J.H., Park, Y.J., Oppermann, U., Jeltsch, A., Haller, F., Fellenberg, J., Lindroth, A.M. and Plass, C.
Nature Communications 11 (1): 5414. 27 October 2020

The GEF Trio controls endothelial cell size and arterial remodeling downstream of Vegf signaling in both zebrafish and cell models.
Klems, A., van Rijssel, J., Ramms, A.S., Wild, R., Hammer, J., Merkel, M., Derenbach, L., Préau, L., Hinkel, R., Suarez-Martinez, I., Schulte-Merker, S., Vidal, R., Sauer, S., Kivelä, R., Alitalo, K., Kupatt, C., van Buul, J.D. and le Noble, F.
Nature Communications 11 (1): 5319. 21 October 2020

Unscrambling fluorophore blinking for comprehensive cluster detection via photoactivated localization microscopy.
Platzer, R., Rossboth, B.K., Schneider, M.C., Sevcsik, E., Baumgart, F., Stockinger, H., Schütz, G.J., Huppa, J.B. and Brameshuber, M.
Nature Communications 11 (1): 4993. 5 October 2020

Cross-regulation of viral kinases with cyclin A secures shutoff of host DNA synthesis.
Bogdanow, B., Schmidt, M., Weisbach, H., Gruska, I., Vetter, B., Imami, K., Ostermann, E., Brune, W., Selbach, M., Hagemeier, C. and Wiebusch, L.
Nature Communications 11 (1): 4845. 24 September 2020

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples.
Bailey, M.H., Meyerson, W.U., Dursi, L.J., Wang, L.B., Dong, G., Liang, W.W., Weerasinghe, A., Li, S., Li, Y., Kelso, S., Saksena, G., Ellrott, K., Wendl, M.C., Wheeler, D.A., Getz, G., Simpson, J.T., Gerstein, M.B. and Ding, Li
Nature Communications 11 (1): 4748. 21 September 2020

A machine learning-based chemoproteomic approach to identify drug targets and binding sites in complex proteomes.
Piazza, I., Beaton, N., Bruderer, R., Knobloch, T., Barbisan, C., Chandat, L., Sudau, A., Siepe, I., Rinner, O., de Souza, N., Picotti, P. and Reiter, L.
Nature Communications 11 (1): 4200. 21 August 2020

Engineering AvidCARs for combinatorial antigen recognition and reversible control of CAR function.
Salzer, B., Schueller, C.M., Zajc, C.U., Peters, T., Schoeber, M.A., Kovacic, B., Buri, M.C., Lobner, E., Dushek, O., Huppa, J.B., Obinger, C., Putz, E.M., Holter, W., Traxlmayr, M.W. and Lehner, M.
Nature Communications 11 (1): 4166. 20 August 2020

Subnanometer-resolution structure determination in situ by hybrid subtomogram averaging - single particle cryo-EM.
Sanchez, R.M., Zhang, Y., Chen, W., Dietrich, L. and Kudryashev, M.
Nature Communications 11 (1): 3709. 24 July 2020

H3K9me3-mediated epigenetic regulation of senescence in mice predicts outcome of lymphoma patients.
Schleich, K., Kase, J., Dörr, J.R., Trescher, S., Bhattacharya, A., Yu, Y., Wailes, E.M., Fan, D.N.Y., Lohneis, P., Milanovic, M., Lau, A., Lenze, D., Hummel, M., Chapuy, B., Leser, U., Reimann, M., Lee, S. and Schmitt, C.A.
Nature Communications 11 (1): 3651. 20 July 2020

Deep learning for genomics using Janggu.
Kopp, W., Monti, R., Tamburrini, A., Ohler, U. and Akalin, A.
Nature Communications 11 (1): 3488. 13 July 2020

Polymer physics indicates chromatin folding variability across single-cells results from state degeneracy in phase separation.
Conte, M., Fiorillo, L., Bianco, S., Chiariello, A.M., Esposito, A. and Nicodemi, M.
Nature Communications 11 (1): 3289. 3 July 2020

Deconstructing sarcomeric structure-function relations in titin-BioID knock-in mice.
Rudolph, F., Fink, C., Hüttemeister, J., Kirchner, M., Radke, M.H., Lopez Carballo, J., Wagner, E., Kohl, T., Lehnart, S.E., Mertins, P. and Gotthardt, M.
Nature Communications 11 (1): 3133. 19 June 2020

Transcriptomics and proteomics reveal a cooperation between interferon and T-helper 17 cells in neuromyelitis optica.
Agasing, A.M., Wu, Q., Khatri, B., Borisow, N., Ruprecht, K., Brandt, A.U., Gawde, S., Kumar, G., Quinn, J.L., Ko, R.M., Mao-Draayer, Y., Lessard, C.J., Paul, F. and Axtell, R.C.
Nature Communications 11 (1): 2856. 5 June 2020

Partner independent fusion gene detection by multiplexed CRISPR-Cas9 enrichment and long read nanopore sequencing.
Stangl, C., de Blank, S., Renkens, I., Westera, L., Verbeek, T., Valle-Inclan, J.E., Chamorro González, R., Henssen, A.G., van Roosmalen, M.J., Stam, R.W., Voest, E.E., Kloosterman, W.P., van Haaften, G. and Monroe, G.R.
Nature Communications 11 (1): 2861. 5 June 2020

FoxO1-Dio2 signaling axis governs cardiomyocyte thyroid hormone metabolism and hypertrophic growth.
Ferdous, A., Wang, Z.V., Luo, Y., Li, D.L., Luo, X., Schiattarella, G.G., Altamirano, F., May, H.I., Battiprolu, P.K., Nguyen, A., Rothermel, B.A., Lavandero, S., Gillette, T.G. and Hill, J.A.
Nature Communications 11 (1): 2551. 21 May 2020

Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma.
Marchetto, A., Ohmura, S., Orth, M.F., Knott, M.M.L., Colombo, M.V., Arrigoni, C., Bardinet, V., Saucier, D., Wehweck, F.S., Li, J., Stein, S., Gerke, J.S., Baldauf, M.C., Musa, J., Dallmayer, M., Romero-Pérez, L., Hölting, T.L.B., Amatruda, J.F., Cossarizza, A., Henssen, A.G., Kirchner, T., Moretti, M., Cidre-Aranaz, F., Sannino, G. and Grünewald, T.G.P.
Nature Communications 11 (1): 2423. 15 May 2020

LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development.
Vinckier, N.K., Patel, N.A., Geusz, R.J., Wang, A., Wang, J., Matta, I., Harrington, A.R., Wortham, M., Wetton, N., Wang, J., Jhala, U.S., Rosenfeld, M.G., Benner, C.W., Shih, H.P. and Sander, M.
Nature Communications 11 (1): 2082. 29 April 2020

Integrative functional genomics decodes herpes simplex virus 1.
Whisnant, A.W., Jürges, C.S., Hennig, T., Wyler, E., Prusty, B., Rutkowski, A.J., L'hernault, A., Djakovic, L., Göbel, M., Döring, K., Menegatti, J., Antrobus, R., Matheson, N.J., Künzig, F.W.H., Mastrobuoni, G., Bielow, C., Kempa, S., Liang, C., Dandekar, T., Zimmer, R., Landthaler, M., Grässer, F., Lehner, P.J., Friedel, C.C., Erhard, F. and Dölken, L.
Nature Communications 11 (1): 2038. 27 April 2020

Apolipoprotein J is a hepatokine regulating muscle glucose metabolism and insulin sensitivity.
Seo, J.A., Kang, M.C., Yang, W.M., Hwang, W.M., Kim, S.S., Hong, S.H., Heo, J.I., Vijyakumar, A., Pereira de Moura, L., Uner, A., Huang, H., Lee, S.H., Lima, I.S., Park, K.S., Kim, M.S., Dagon, Y., Willnow, T.E., Aroda, V., Ciaraldi, T.P., Henry, R.R. and Kim, Y.B.
Nature Communications 11 (1): 2024. 24 April 2020

Propagation of hippocampal ripples to the neocortex by way of a subiculum-retrosplenial pathway.
Nitzan, N., McKenzie, S., Beed, P., English, D.F., Oldani, S., Tukker, J.J., Buzsáki, G. and Schmitz, D.
Nature Communications 11 (1): 1947. 23 April 2020

Ribosome profiling at isoform level reveals evolutionary conserved impacts of differential splicing on the proteome.
Reixachs-Solé, M., Ruiz-Orera, J., Albà, M.M. and Eyras, E.
Nature Communications 11 (1): 1768. 14 April 2020

Integrated proteogenomic deep sequencing and analytics accurately identify non-canonical peptides in tumor immunopeptidomes.
Chong, C., Müller, M., Pak, H.S., Harnett, D., Huber, F., Grun, D., Leleu, M., Auger, A., Arnaud, M., Stevenson, B.J., Michaux, J., Bilic, I., Hirsekorn, A., Calviello, L., Simó-Riudalbas, L., Planet, E., Lubiński, J., Bryśkiewicz, M., Wiznerowicz, M., Xenarios, I., Zhang, L., Trono, D., Harari, A., Ohler, U., Coukos, G. and Bassani-Sternberg, M.
Nature Communications 11 (1): 1293. 10 March 2020

Prioritizing disease and trait causal variants at the TNFAIP3 locus using functional and genomic features.
Ray, J.P., de Boer, C.G., Fulco, C.P., Lareau, C.A., Kanai, M., Ulirsch, J.C., Tewhey, R., Ludwig, L.S., Reilly, S.K., Bergman, D.T., Engreitz, J.M., Issner, R., Finucane, H.K., Lander, E.S., Regev, A. and Hacohen, N.
Nature Communications 11 (1): 1237. 6 March 2020

Tracing tumorigenesis in a solid tumor model at single-cell resolution.
Praktiknjo, S.D., Obermayer, B., Zhu, Q., Fang, L., Liu, H., Quinn, H., Stoeckius, M., Kocks, C., Birchmeier, W. and Rajewsky, N.
Nature Communications 11 (1): 991. 20 February 2020

Inhibiting WNT and NOTCH in renal cancer stem cells and the implications for human patients.
Fendler, A., Bauer, D., Busch, J., Jung, K., Wulf-Goldenberg, A., Kunz, S., Song, K., Myszczyszyn, A., Elezkurtaj, S., Erguen, B., Jung, S., Chen, W. and Birchmeier, W.
Nature Communications 11 (1): 929. 17 February 2020

High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations.
Zhang, Y., Chen, F., Fonseca, N.A., He, Y., Fujita, M., Nakagawa, H., Zhang, Z., Brazma, A. and Creighton, C.J.
Nature Communications 11 (1): 736. 5 February 2020

Human and mouse essentiality screens as a resource for disease gene discovery.
Cacheiro, P., Muñoz-Fuentes, V., Murray, S.A., Dickinson, M.E., Bucan, M., Nutter, L.M.J., Peterson, K.A., Haselimashhadi, H., Flenniken, A.M., Morgan, H., Westerberg, H., Konopka, T., Hsu, C.W., Christiansen, A., Lanza, D.G., Beaudet, A.L., Heaney, J.D., Fuchs, H., Gailus-Durner, V., Sorg, T., Prochazka, J., Novosadova, V., Lelliott, C.J., Wardle-Jones, H., Wells, S., Teboul, L., Cater, H., Stewart, M., Hough, T., Wurst, W., Sedlacek, R., Adams, D.J., Seavitt, J.R., Tocchini-Valentini, G., Mammano, F., Braun, R.E., McKerlie, C., Herault, Y., de Angelis, M.H., Mallon, A.M., Lloyd, K.C.K., Brown, S.D.M., Parkinson, H., Meehan, T.F. and Smedley, D.
Nature Communications 11 (1): 655. 31 January 2020

Rapid and deep-scale ubiquitylation profiling for biology and translational research.
Udeshi, N.D., Mani, D.C., Satpathy, S., Fereshetian, S., Gasser, J.A., Svinkina, T., Olive, M.E., Ebert, B.L., Mertins, P. and Carr, S.A.
Nature Communications 11 (1): 359. 17 January 2020

Cold-induced urticarial autoinflammatory syndrome related to factor XII activation.
Scheffel, J., Mahnke, N.A., Hofman, Z.L.M., Maat, S.d., Wu, J., Bonnekoh, H., Pengelly, R.J., Ennis, S., Holloway, J.W., Kirchner, M., Mertins, P., Church, M.K., Maurer, M., Maas, C. and Krause, K.
Nature Communications 11 (1): 179. 10 January 2020

Single-cell analysis based dissection of clonality in myelofibrosis.
Mylonas, E., Yoshida, K., Frick, M., Hoyer, K., Christen, F., Kaeda, J., Obenaus, M., Noerenberg, D., Hennch, C., Chan, W., Ochi, Y., Shiraishi, Y., Shiozawa, Y., Zenz, T., Oakes, C.C., Sawitzki, B., Schwarz, M., Bullinger, L., le Coutre, P., Rose-Zerilli, M.J.J., Ogawa, S. and Damm, F.
Nature Communications 11 (1): 73. 7 January 2020

Tissue-infiltrating macrophages mediate an exosome-based metabolic reprogramming upon DNA damage.
Goulielmaki, E., Ioannidou, A., Tsekrekou, M., Stratigi, K., Poutakidou, I.K., Gkirtzimanaki, K., Aivaliotis, M., Evangelou, K., Topalis, P., Altmüller, J., Gorgoulis, V.G., Chatzinikolaou, G. and Garinis, G.A.
Nature Communications 11 (1): 42. 2 January 2020

2019

CD8(+) T cell-mediated endotheliopathy is a targetable mechanism of neuro-inflammation in Susac syndrome.
Gross, C.C., Meyer, C., Bhatia, U., Yshii, L., Kleffner, I., Bauer, J., Tröscher, A.R., Schulte-Mecklenbeck, A., Herich, S., Schneider-Hohendorf, T., Plate, H., Kuhlmann, T., Schwaninger, M., Brück, W., Pawlitzki, M., Laplaud, D.A., Loussouarn, D., Parratt, J., Barnett, M., Buckland, M.E., Hardy, T.A., Reddel, S.W., Ringelstein, M., Dörr, J., Wildemann, B., Kraemer, M., Lassmann, H., Höftberger, R., Beltrán, E., Dornmair, K., Schwab, N., Klotz, L., Meuth, S.G., Martin-Blondel, G., Wiendl, H. and Liblau, R.
Nature Communications 10 (1): 5779. 18 December 2019

Human muscle-derived CLEC14A-positive cells regenerate muscle independent of PAX7.
Marg, A., Escobar Fernandez, H., Karaiskos, N., Grunwald, S.A., Metzler, E., Kieshauer, J., Sauer, S., Pasemann, D., Malfatti, E., Mompoint, D., Quijano-Roy, S., Boltengagen, A., Schneider, J., Schülke, M., Kunz, S., Carlier, R., Birchmeier, C., Amthor, H., Spuler, A., Kocks, C., Rajewsky, N. and Spuler, S.
Nature Communications 10 (1): 5776. 18 December 2019

The dynamic proteome of influenza A virus infection identifies M segment splicing as a host range determinant.
Bogdanow, B., Wang, X., Eichelbaum, K., Sadewasser, A., Husic, I., Paki, K., Budt, M., Hergeselle, M., Vetter, B., Hou, J., Chen, W., Wiebusch, L., Meyer, I.M., Wolff, T. and Selbach, M.
Nature Communications 10 (1): 5518. 4 December 2019

Elevated aldosterone and blood pressure in a mouse model of familial hyperaldosteronism with ClC-2 mutation.
Schewe, J., Seidel, E., Forslund, S., Marko, L., Peters, J., Muller, D.N., Fahlke, C., Stölting, G. and Scholl, U.
Nature Communications 10 (1): 5155. 14 November 2019

Full-length transcriptome reconstruction reveals a large diversity of RNA and protein isoforms in rat hippocampus.
Wang, X., You, X., Langer, J.D., Hou, J., Rupprecht, F., Vlatkovic, I., Quedenau, C., Tushev, G., Epstein, I., Schaefke, B., Sun, W., Fang, L., Li, G., Hu, Y., Schuman, E.M. and Chen, W.
Nature Communications 10 (1): 5009. 1 November 2019

Unstable TTTTA/TTTCA expansions in MARCH6 are associated with Familial Adult Myoclonic Epilepsy type 3.
Florian, R.T., Kraft, F., Leitão, E., Kaya, S., Klebe, S., Magnin, E., van Rootselaar, A.F., Buratti, J., Kühnel, T., Schröder, C., Giesselmann, S., Tschernoster, N., Altmüller, J., Lamiral, A., Keren, B., Nava, C., Bouteiller, D., Forlani, S., Jornea, L., Kubica, R., Ye, T., Plassard, D., Jost, B., Meyer, V., Deleuze, J.F., Delpu, Y., Avarello, M.D.M., Vijfhuizen, L.S., Rudolf, G., Hirsch, E., Kroes, T., Reif, P.S., Rosenow, F., Ganos, C., Vidailhet, M., Thivard, L., Mathieu, A., Bourgeron, T., Kurth, I., Rafehi, H., Steenpass, L., Horsthemke, B., LeGuern, E., Klein, K.M., Labauge, P., Bennett, M.F., Bahlo, M., Gecz, J., Corbett, M.A., Tijssen, M.A.J, van den Maagdenberg, A.M.J.M. and Depienne, C.
Nature Communications 10 (1): 4919. 29 October 2019

Single-cell RNA-sequencing of herpes simplex virus 1-infected cells connects NRF2 activation to an antiviral program.
Wyler, E., Franke, V., Menegatti, J., Kocks, C., Boltengagen, A., Praktiknjo, S., Walch-Rückheim, B., Bosse, J., Rajewsky, N., Grässer, F., Akalin, A. and Landthaler, M.
Nature Communications 10 (1): 4878. 25 October 2019

B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage.
Wong, J.B., Hewitt, S.L., Heltemes-Harris, L.M., Mandal, M., Johnson, K., Rajewsky, K., Koralov, S.B., Clark, M.R., Farrar, M.A. and Skok, J.A.
Nature Communications 10 (1): 4768. 18 October 2019

Pathogenesis of hypertension in a mouse model for human CLCN2 related hyperaldosteronism.
Göppner, C., Orozco, I.J., Hoegg-Beiler, M.B., Soria, A.H., Hübner, C.A., Fernandes-Rosa, F.L., Boulkroun, S., Zennaro, M.C. and Jentsch, T.J.
Nature Communications 10 (1): 4678. 15 October 2019

R-spondin 3 promotes stem cell recovery and epithelial regeneration in the colon.
Harnack, C., Berger, H., Antanaviciute, A., Vidal, R., Sauer, S., Simmons, A., Meyer, T.F. and Sigal, M.
Nature Communications 10 (1): 4368. 25 September 2019

Identification of proteins and miRNAs that specifically bind an mRNA in vivo.
Theil, K., Imami, K. and Rajewsky, N.
Nature Communications 10 (1): 4205. 16 September 2019

Maximizing binary interactome mapping with a minimal number of assays.
Choi, S.G., Olivet, J., Cassonnet, P., Vidalain, P.O., Luck, K., Lambourne, L., Spirohn, K., Lemmens, I., Dos Santos, M., Demeret, C., Jones, L., Rangarajan, S., Bian, W., Coutant, E.P., Janin, Y.L., van der Werf, S., Trepte, P., Wanker, E.E., De Las Rivas, J., Tavernier, J., Twizere, J.C., Hao, T., Hill, D.E., Vidal, M., Calderwood, M.A. and Jacob, Y.
Nature Communications 10 (1): 3907. 29 August 2019

Integrative and comparative genomic analyses identify clinically relevant pulmonary carcinoid groups and unveil the supra-carcinoids.
Alcala, N., Leblay, N., Gabriel, A.A.G., Mangiante, L., Hervas, D., Giffon, T., Sertier, A.S., Ferrari, A., Derks, J., Ghantous, A., Delhomme, T.M., Chabrier, A., Cuenin, C., Abedi-Ardekani, B., Boland, A., Olaso, R., Meyer, V., Altmuller, J., Le Calvez-Kelm, F., Durand, G., Voegele, C., Boyault, S., Moonen, L., Lemaitre, N., Lorimier, P., Toffart, A.C., Soltermann, A., Clement, J.H., Saenger, J., Field, J.K., Brevet, M., Blanc-Fournier, C., Galateau-Salle, F., Le Stang, N., Russell, P.A., Wright, G., Sozzi, G., Pastorino, U., Lacomme, S., Vignaud, J.M., Hofman, V., Hofman, P., Brustugun, O.T., Lund-Iversen, M., Thomas de Montpreville, V., Muscarella, L.A., Graziano, P., Popper, H., Stojsic, J., Deleuze, J.F., Herceg, Z., Viari, A., Nuernberg, P., Pelosi, G., Dingemans, A.M.C., Milione, M., Roz, L., Brcic, L., Volante, M., Papotti, M.G., Caux, C., Sandoval, J., Hernandez-Vargas, H., Brambilla, E., Speel, E.J.M., Girard, N., Lantuejoul, S., McKay, J.D., Foll, M. and Fernandez-Cuesta, L.
Nature Communications 10 (1): 3407. 20 August 2019

WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling.
Chen, H., Moreno-Moral, A., Pesce, F., Devapragash, N., Mancini, M., Heng, E.L., Rotival, M., Srivastava, P.K., Harmston, N., Shkura, K., Rackham, O.J.L., Yu, W.P., Sun, X.M., Tee, N.G.Z., Tan, E.L.S., Barton, P.J.R., Felkin, L.E., Lara-Pezzi, E., Angelini, G., Beltrami, C., Pravenec, M., Schafer, A., Bottolo, L., Hubner, N., Emanueli, C., Cook, S.A. and Petretto, E.
Nature Communications 10 (1): 3616. 9 August 2019

Curvature induction and membrane remodeling by FAM134B reticulon homology domain assist selective ER-phagy.
Bhaskara, R.M., Grumati, P., Garcia-Pardo, J., Kalayil, S., Covarrubias-Pinto, A., Chen, W., Kudryashev, M., Dikic, I. and Hummer, G.
Nature Communications 10 (1): 2370. 30 May 2019

Blimp1(+) cells generate functional mouse sebaceous gland organoids in vitro.
Feldman, A., Mukha, D., Maor, I.I., Sedov, E., Koren, E., Yosefzon, Y., Shlomi, T. and Fuchs, Y.
Nature Communications 10 (1): 2348. 28 May 2019

Pancreatic islet chromatin accessibility and conformation reveals distal enhancer networks of type 2 diabetes risk.
Greenwald, W.W., Chiou, J., Yan, J., Qiu, Y., Dai, N., Wang, A., Nariai, N., Aylward, A., Han, J.Y., Kadakia, N., Regue, L., Okino, M.L., Drees, F., Kramer, D., Vinckier, N., Minichiello, L., Gorkin, D., Avruch, J., Frazer, K.A., Sander, M., Ren, B. and Gaulton, K.J.
Nature Communications 10 (1): 2078. 7 May 2019

Clonal evolution patterns in acute myeloid leukemia with NPM1 mutation.
Cocciardi, S., Dolnik, A., Kapp-Schwoerer, S., Rücker, F.G., Lux, S., Blätte, T.J., Skambraks, S., Krönke, J., Heidel, F.H., Schnöder, T.M., Corbacioglu, A., Gaidzik, V.I., Paschka, P., Teleanu, V., Göhring, G., Thol, F., Heuser, M., Ganser, A., Weber, D., Sträng, E., Kestler, H.A., Döhner, H., Bullinger, L. and Döhner, K.
Nature Communications 10 (1): 2031. 2 May 2019

Multi-platform discovery of haplotype-resolved structural variation in human genomes.
Chaisson, M.J.P., Sanders, A.D., Zhao, X., Malhotra, A., Porubsky, D., Rausch, T., Gardner, E.J., Rodriguez, O.L., Guo, L., Collins, R.L., Fan, X., Wen, J., Handsaker, R.E., Fairley, S., Kronenberg, Z.N., Kong, X., Hormozdiari, F., Lee, D., Wenger, A.M., Hastie, A.R., Antaki, D., Anantharaman, T., Audano, P.A., Brand, H., Cantsilieris, S., Cao, H., Cerveira, E., Chen, C., Chen, X., Chin, C.S., Chong, Z., Chuang, N.T., Lambert, C.C., Church, D.M., Clarke, L., Farrell, A., Flores, J., Galeev, T., Gorkin, D.U., Gujral, M., Guryev, V., Heaton, W.H., Korlach, J., Kumar, S., Kwon, J.Y., Lam, E.T., Lee, J.E., Lee, J., Lee, W.P., Lee, S.P., Li, S., Marks, P., Viaud-Martinez, K., Meiers, S., Munson, K.M., Navarro, F.C.P., Nelson, B.J., Nodzak, C., Noor, A., Kyriazopoulou-Panagiotopoulou, S., Pang, A.W.C., Qiu, Y., Rosanio, G., Ryan, M., Stütz, A., Spierings, D.C.J., Ward, A., Welch, A.E., Xiao, M., Xu, W., Zhang, C., Zhu, Q., Zheng-Bradley, X., Lowy, E., Yakneen, S., McCarroll, S., Jun, G., Ding, L., Koh, C.L., Ren, B., Flicek, P., Chen, K., Gerstein, M.B., Kwok, P.Y., Lansdorp, P.M., Marth, G.T., Sebat, J., Shi, X., Bashir, A., Ye, K., Devine, S.E., Talkowski, M.E., Mills, R.E., Marschall, T., Korbel, J.O., Eichler, E.E. and Lee, C.
Nature Communications 10 (1): 1784. 16 April 2019

Global identification of functional microRNA-mRNA interactions in Drosophila.
Wessels, H.H., Lebedeva, S., Hirsekorn, A., Wurmus, R., Akalin, A., Mukherjee, N. and Ohler, U.
Nature Communications 10 (1): 1626. 9 April 2019

Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells.
Niogret, C., Miah, S.M.S., Rota, G., Fonta, N.P., Wang, H., Held, W., Birchmeier, W., Sexl, V., Yang, W., Vivier, E., Ho, P.C., Brossay, L. and Guarda, G.
Nature Communications 10 (1): 1444. 29 March 2019

Homozygous frameshift mutations in FAT1 cause a syndrome characterized by colobomatous-microphthalmia, ptosis, nephropathy and syndactyly.
Lahrouchi, N., George, A., Ratbi, I., Schneider, R., Elalaoui, S.C., Moosa, S., Bharti, S., Sharma, R., Abu-Asab, M., Onojafe, F., Adadi, N., Lodder, E.M., Laarabi, F.Z., Lamsyah, Y., Elorch, H., Chebbar, I., Postma, A.V., Lougaris, V., Plebani, A., Altmueller, J., Kyrieleis, H., Meiner, V., McNeill, H., Bharti, K., Lyonnet, S., Wollnik, B., Henrion-Caude, A., Berraho, A., Hildebrandt, F., Bezzina, C.R., Brooks, B.P. and Sefiani, A.
Nature Communications 10 (1): 1180. 12 March 2019

Microbial abundance, activity and population genomic profiling with mOTUs2.
Milanese, A., Mende, D.R., Paoli, L., Salazar, G., Ruscheweyh, H.J., Cuenca, M., Hingamp, P., Alves, R., Costea, P.I., Coelho, L.P., Schmidt, T.S.B., Almeida, A., Mitchell, A.L., Finn, R.D., Huerta-Cepas, J., Bork, P., Zeller, G. and Sunagawa, S.
Nature Communications 10 (1): 1014. 4 March 2019

Purification of cross-linked RNA-protein complexes by phenol-toluol extraction.
Urdaneta, E.C., Vieira-Vieira, C.H., Hick, T., Wessels, H.H., Figini, D., Moschall, R., Medenbach, J., Ohler, U., Granneman, S., Selbach, M. and Beckmann, B.M.
Nature Communications 10 (1): 990. 1 March 2019

E47 modulates hepatic glucocorticoid action.
Hemmer, M.C., Wierer, M., Schachtrup, K., Downes, M., Hübner, N., Evans, R.M. and Uhlenhaut, N.H.
Nature Communications 10 (1): 306. 18 January 2019

Chi3l3 induces oligodendrogenesis in an experimental model of autoimmune neuroinflammation.
Starossom, S.C., Campo Garcia, J., Woelfle, T., Romero-Suarez, S., Olah, M., Watanabe, F., Cao, L., Yeste, A., Tukker, J.J., Quintana, F.J., Imitola, J., Witzel, F., Schmitz, D., Morkel, M., Paul, F., Infante-Duarte, C. and Khoury, S.J.
Nature Communications 10 (1): 217. 15 January 2019

2018

A virus-encoded type I interferon decoy receptor enables evasion of host immunity through cell-surface binding.
Hernáez, B., Alonso-Lobo, J.M., Montanuy, I., Fischer, C., Sauer, S., Sigal, L., Sevilla, N. and Alcamí, A.
Nature Communications 9 (1): 5440. 21 December 2018

aPKC controls endothelial growth by modulating c-Myc via FoxO1 DNA-binding ability.
Riddell, M., Nakayama, A., Hikita, T., Mirzapourshafiyi, F., Kawamura, T., Pasha, A., Li, M., Masuzawa, M., Looso, M., Steinbacher, T., Ebnet, K., Potente, M., Hirose, T., Ohno, S., Fleming, I., Gattenlöhner, S., Aung, P.P., Phung, T., Yamasaki, O., Yanagi, T., Umemura, H. and Nakayama, M.
Nature Communications 9 (1): 5357. 17 December 2018

Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis.
Campa, C.C., Silva, R.L., Margaria, J.P., Pirali, T., Mattos, M.S., Kraemer, L.R., Reis, D.C., Grosa, G., Copperi, F., Dalmarco, E.M., Lima-Júnior, R.C.P., Aprile, S., Sala, V., Dal Bello, F., Prado, D.S., Alves-Filho, J.C., Medana, C., Cassali, G.D., Tron, G.C., Teixeira, M.M., Ciraolo, E., Russo, R.C. and Hirsch, E.
Nature Communications 9 (1): 5232. 12 December 2018

GPCR-specific autoantibody signatures are associated with physiological and pathological immune homeostasis.
Cabral-Marques, O., Marques, A., Giil, L.M., De Vito, R., Rademacher, J., Günther, J., Lange, T., Humrich, J.Y., Klapa, S., Schinke, S., Schimke, L.F., Marschner, G., Pitann, S., Adler, S., Dechend, R., Müller, D.N., Braicu, I., Sehouli, J., Schulze-Forster, K., Trippel, T., Scheibenbogen, C., Staff, A., Mertens, P.R., Löbel, M., Mastroianni, J., Plattfaut, C., Gieseler, F., Dragun, D., Engelhardt, B.E., Fernandez-Cabezudo, M.J., Ochs, H.D., Al-Ramadi, B.K., Lamprecht, P., Mueller, A., Heidecke, H. and Riemekasten, G.
Nature Communications 9 (1): 5224. 6 December 2018

Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors.
Escot, S., Willnow, D., Naumann, H., Di Francescantonio, S. and Spagnoli, F.M.
Nature Communications 9 (1): 5082. 30 November 2018

TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets.
Decaesteker, B., Denecker, G., Van Neste, C., Dolman, E.M., Van Loocke, W., Gartlgruber, M., Nunes, C., De Vloed, F., Depuydt, P., Verboom, K., Rombaut, D., Loontiens, S., De Wyn, J., Kholosy, W.M., Koopmans, B., Essing, A.H.W., Herrmann, C., Dreidax, D., Durinck, K., Deforce, D., van Nieuwerburgh, F., Henssen, A., Versteeg, R., Boeva, V., Schleiermacher, G., van Nes, J., Mestdagh, P., Vanhauwaert, S., Schulte, J.H., Westermann, F., Molenaar, J.J., De Preter, K. and Speleman, F.
Nature Communications 9 (1): 4866. 19 November 2018

Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility.
Angulo-Urarte, A., Casado, P., Castillo, S.D., Kobialka, P., Kotini, M.P., Figueiredo, A.M., Castel, P., Rajeeve, V., Milà-Guasch, M., Millan, J., Wiesner, C., Serra, H., Muixi, L., Casanovas, O., Viñals, F., Affolter, M., Gerhardt, H., Huveneers, S., Belting, H.G., Cutillas, P.R. and Graupera, M.
Nature Communications 9 (1): 4826. 16 November 2018

Potassium channel-based optogenetic silencing.
Bernal Sierra, Y.A., Rost, B.R., Pofahl, M., Fernandes, A.M., Kopton, R.A., Moser, S., Holtkamp, D., Masala, N., Beed, P., Tukker, J.J., Oldani, S., Bönigk, W., Kohl, P., Baier, H., Schneider-Warme, F., Hegemann, P., Beck, H., Seifert, R. and Schmitz, D.
Nature Communications 9 (1): 4611. 5 November 2018

ARTS mediates apoptosis and regeneration of the intestinal stem cell niche.
Koren, E., Yosefzon, Y., Ankawa, R., Soteriou, D., Jacob, A., Nevelsky, A., Ben-Yosef, R., Bar-Sela, G. and Fuchs, Y.
Nature Communications 9 (1): 4582. 2 November 2018

Determinants of promoter and enhancer transcription directionality in metazoans.
Ibrahim, M.M., Karabacak, A., Glahs, A., Kolundzic, E., Hirsekorn, A., Carda, A., Tursun, B., Zinzen, R.P., Lacadie, S.A. and Ohler, U.
Nature Communications 9 (1): 4472. 26 October 2018

Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells.
Stone, O.A., El-Brolosy, M., Wilhelm, K., Liu, X., Romão, A.M., Grillo, E., Lai, J.K.H., Günther, S., Jeratsch, S., Kuenne, C., Lee, I.C., Braun, T., Santoro, M.M., Locasale, J.W., Potente, M. and Stainier, D.Y.R.
Nature Communications 9 (1): 4077. 9 October 2018

Genetic and pharmacological regulation of the endocannabinoid CB1 receptor in Duchenne muscular dystrophy.
Iannotti, F.A., Pagano, E., Guardiola, O., Adinolfi, S., Saccone, V., Consalvi, S., Piscitelli, F., Gazzerro, E., Busetto, G., Carrella, D., Capasso, R., Puri, P.L., Minchiotti, G. and Di Marzo, V.
Nature Communications 9 (1): 3950. 27 September 2018

Structural basis for membrane tethering by a bacterial dynamin-like pair.
Liu, J., Noel, J.K. and Low, H.H.
Nature Communications 9 (1): 3345. 21 August 2018

The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis.
Zehender, A., Huang, J., Györfi, A.H., Matei, A.E., Trinh-Minh, T., Xu, X., Li, Y.N., Chen, C.W., Lin, J., Dees, C., Beyer, C., Gelse, K., Zhang, Z.Y., Bergmann, C., Ramming, A., Birchmeier, W., Distler, O., Schett, G. and Distler, J.H.W.
Nature Communications 9 (1): 3259. 14 August 2018

Role of VTA dopamine neurons and neuroligin 3 in sociability traits related to nonfamiliar conspecific interaction.
Bariselli, S., Hörnberg, H., Prévost-Solié, C., Musardo, S., Hatstatt-Burklé, L., Scheiffele, P. and Bellone, C.
Nature Communications 9 (1): 3173. 9 August 2018

Embryos and embryonic stem cells from the white rhinoceros.
Hildebrandt, T.B., Hermes, R., Colleoni, S., Diecke, S., Holtze, S., Renfree, M.B., Stejskal, J., Hayashi, K., Drukker, M., Loi, P., Göritz, F., Lazzari, G. and Galli, C.
Nature Communications 9 (1): 2589. 4 July 2018

Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity.
Merks, A.M., Swinarski, M., Meyer, A.M., Müller, N.V., Özcan, I., Donat, S., Burger, A., Gilbert, S., Mosimann, C., Abdelilah-Seyfried, S. and Panáková, D.
Nature Communications 9 (1): 2161. 4 June 2018

Postnatal DNA demethylation and its role in tissue maturation.
Reizel, Y., Sabag, O., Skversky, Y., Spiro, A., Steinberg, B., Bernstein, D., Wang, A., Kieckhaefer, J., Li, C., Pikarsky, E., Levin-Klein, R., Goren, A., Rajewsky, K., Kaestner, K.H. and Cedar, H.
Nature Communications 9 (1): 2040. 23 May 2018

Continuous addition of progenitors forms the cardiac ventricle in zebrafish.
Felker, A., Prummel, K.D., Merks, A.M., Mickoleit, M., Brombacher, E.C., Huisken, J., Panáková, D. and Mosimann, C.
Nature Communications 9 (1): 2001. 21 May 2018

LRRC8/VRAC anion channels enhance β-cell glucose sensing and insulin secretion.
Stuhlmann, T., Planells-Cases, R. and Jentsch, T.J.
Nature Communications 9 (1): 1974. 17 May 2018

Linear mitochondrial DNA is rapidly degraded by components of the replication machinery.
Peeva, V., Blei, D., Trombly, G., Corsi, S., Szukszto, M.J., Rebelo-Guiomar, P., Gammage, P.A., Kudin, A.P., Becker, C., Altmüller, J., Minczuk, M., Zsurka, G. and Kunz, W.S.
Nature Communications 9 (1): 1727. 30 April 2018

Single synaptic inputs drive high-precision action potentials in parvalbumin expressing GABA-ergic cortical neurons in vivo.
Jouhanneau, J.S., Kremkow, J. and Poulet, J.F.A.
Nature Communications 9 (1): 1540. 18 April 2018

Conformational switching within dynamic oligomers underpins toxic gain-of-function by diabetes-associated amyloid.
Birol, M., Kumar, S., Rhoades, E. and Miranker, A.D.
Nature Communications 9 (1): 1312. 3 April 2018

Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control.
Yang, J.Y., Deng, X.Y., Li, Y.S., Ma, X.C., Feng, J.X., Yu, B., Chen, Y., Luo, Y.L., Wang, X., Chen, M.L., Fang, Z.X., Zheng, F.X., Li, Y.P., Zhong, Q., Kang, T.B., Song, L.B., Xu, R.H., Zeng, M.S., Chen, W., Zhang, H., Xie, W. and Gao, S.
Nature Communications 9 (1): 1165. 21 March 2018

Voltage gating of mechanosensitive PIEZO channels.
Moroni, M., Servin-Vences, M.R., Fleischer, R., Sánchez-Carranza, O. and Lewin, G.R.
Nature Communications 9 (1): 1096. 15 March 2018

Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors.
George, J., Walter, V., Peifer, M., Alexandrov, L.B., Seidel, D., Leenders, F., Maas, L., Müller, C., Dahmen, I., Delhomme, T.M., Ardin, M., Leblay, N., Byrnes, G., Sun, R., De Reynies, A., McLeer-Florin, A., Bosco, G., Malchers, F., Menon, R., Altmüller, J., Becker, C., Nürnberg, P., Achter, V., Lang, U., Schneider, P.M., Bogus, M., Soloway, M.G., Wilkerson, M.D., Cun, Y., McKay, J.D., Moro-Sibilot, D., Brambilla, C.G., Lantuejoul, S., Lemaitre, N., Soltermann, A., Weder, W., Tischler, V., Brustugun, O.T., Lund-Iversen, M., Helland, Å., Solberg, S., Ansén, S., Wright, G., Solomon, B., Roz, L., Pastorino, U., Petersen, I., Clement, J.H., Sänger, J., Wolf, J., Vingron, M., Zander, T., Perner, S., Travis, W.D., Haas, S.A., Olivier, M., Foll, M., Büttner, R., Hayes, D.N., Brambilla, E., Fernandez-Cuesta, L. and Thomas, R.K.
Nature Communications 9 (1): 1048. 13 March 2018

Clonal dynamics towards the development of venetoclax resistance in chronic lymphocytic leukemia.
Herling, C.D., Abedpour, N., Weiss, J., Schmitt, A., Jachimowicz, R.D., Merkel, O., Cartolano, M., Oberbeck, S., Mayer, P., Berg, V., Thomalla, D., Kutsch, N., Stiefelhagen, M., Cramer, P., Wendtner, C.M., Persigehl, T., Saleh, A., Altmüller, J., Nürnberg, P., Pallasch, C., Achter, V., Lang, U., Eichhorst, B., Castiglione, R., Schäfer, S.C., Büttner, R., Kreuzer, K.A., Reinhardt, H.C., Hallek, M., Frenzel, L.P. and Peifer, M.
Nature Communications 9 (1): 727. 20 February 2018

Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL.
Schrader, A., Crispatzu, G., Oberbeck, S., Mayer, P., Pützer, S., von Jan, J., Vasyutina, E., Warner, K., Weit, N., Pflug, N., Braun, T., Andersson, E.I., Yadav, B., Riabinska, A., Maurer, B., Ventura Ferreira, M.S., Beier, F., Altmüller, J., Lanasa, M., Herling, C.D., Haferlach, T., Stilgenbauer, S., Hopfinger, G., Peifer, M., Brümmendorf, T.H., Nürnberg, P., Elenitoba-Johnson, K.S.J., Zha, S., Hallek, M., Moriggl, R., Reinhardt, H.C., Stern, M.H., Mustjoki, S., Newrzela, S., Frommolt, P. and Herling, M.
Nature Communications 9 (1): 697. 15 February 2018

A global ocean atlas of eukaryotic genes.
Carradec, Q., Pelletier, E., Da Silva, C., Alberti, A., Seeleuthner, Y., Blanc-Mathieu, R., Lima-Mendez, G., Rocha, F., Tirichine, L., Labadie, K., Kirilovsky, A., Bertrand, A., Engelen, S., Madoui, M.A., Méheust, R., Poulain, J., Romac, S., Richter, D.J., Yoshikawa, G., Dimier, C., Kandels-Lewis, S., Picheral, M., Searson, S., Jaillon, O., Aury, J.M., Karsenti, E., Sullivan, M.B., Sunagawa, S., Bork, P., Not, F., Hingamp, P., Raes, J., Guidi, L., Ogata, H., De Vargas, C., Iudicone, D., Bowler, C. and Wincker, P.
Nature Communications 9 (1): 373. 25 January 2018

Identification of genetic elements in metabolism by high-throughput mouse phenotyping.
Rozman, J., Rathkolb, B., Oestereicher, M.A., Schütt, C., Ravindranath, A.C., Leuchtenberger, S., Sharma, S., Kistler, M., Willershäuser, M., Brommage, R., Meehan, T.F., Mason, J., Haselimashhadi, H., Hough, T., Mallon, A.M., Wells, S., Santos, L., Lelliott, C.J., White, J.K., Sorg, T., Champy, M.F., Bower, L.R., Reynolds, C. L., Flenniken, A.M., Murray, St.A., Nutter, L.M.J., Svenson, K.L., West, D., Tocchini-Valentini, G.P., Beaudet, A.L., Bosch, F., Braun, R.B., Dobbie, M.S., Gao, X., Herault, Y., Moshiri, A., Moore, B.A., Kent Lloyd, K.C., McKerlie, C., Masuya, H., Tanaka, N., Flicek, P., Parkinson, H.E., Sedlacek, R., Seong, J.K., Wang, C.K.L., Moore, M., Brown, S.D., Tschöp, M.H., Wurst, W., Klingenspor, M., Wolf, E., Beckers, J., Machicao, F., Peter, A., Staiger, H., Häring, H.U., Grallert, H., Campillos, M., Maier, H., Fuchs, H., Gailus-Durner, V., Werner, T. and Hrabe de Angelis, M.
Nature Communications 9 (1): 288. 18 January 2018

Perturbation-response genes reveal signaling footprints in cancer gene expression.
Schubert, M., Klinger, B., Klünemann, M., Sieber, A., Uhlitz, F., Sauer, S., Garnett, M.J., Blüthgen, N. and Saez-Rodriguez, J.
Nature Communications 9 (1): 20. 2 January 2018

2017

Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1.
Pose-Utrilla, J., García-Guerra, L., Del Puerto, A., Martin, A., Jurado-Arjona, J., De León-Reyes, N.S., Gamir-Morralla, A., Sebastián-Serrano, A., García-Gallo, M., Kremer, L., Fielitz, J., Ireson, C., Pérez-Álvarez, M.J., Ferrer, I., Hernández, F., Ávila, J., Lasa, M., Campanero, M.R. and Iglesias, T.
Nature Communications 8 (1): 2275. 22 December 2017

Evolutionary action and structural basis of the allosteric switch controlling β(2)AR functional selectivity.
Schönegge, A.M., Gallion, J., Picard, L.P., Wilkins, A.D., Le Gouill, C., Audet, M., Stallaert, W., Lohse, M.J., Kimmel, M., Lichtarge, O. and Bouvier, M.
Nature Communications 8 (1): 2169. 18 December 2017

Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling.
Sassi, Y., Avramopoulos, P., Ramanujam, D., Grüter, L., Werfel, S., Giosele, S., Brunner, A.D., Esfandyari, D., Papadopoulou, A.S, De Strooper, B., Hübner, N., Kumarswamy, R., Thum, T., Yin, X., Mayr, M., Laggerbauer, B. and Engelhardt, S.
Nature Communications 8 (1): 1614. 20 November 2017

Transient cardiomyocyte fusion regulates cardiac development in zebrafish.
Sawamiphak, S., Kontarakis, Z., Filosa, A., Reischauer, S. and Stainier, D.Y.R.
Nature Communications 8 (1): 1525. 15 November 2017

Dense and accurate whole-chromosome haplotyping of individual genomes.
Porubsky, D., Garg, S., Sanders, A.D., Korbel, J.O., Guryev, V., Lansdorp, P.M. and Marschall, T.
Nature Communications 8 (1): 1293. 3 November 2017

Genome-wide association study identifies the SERPINB gene cluster as a susceptibility locus for food allergy.
Marenholz, I., Grosche, S., Kalb, B., Rüschendorf, F., Blümchen, K., Schlags, R., Harandi, N., Price, M., Hansen, G., Seidenberg, J., Röblitz, H., Yürek, S., Tschirner, S., Hong, X., Wang, X., Homuth, G., Schmidt, C.O., Nöthen, M.M., Hübner, N., Niggemann, B., Beyer, K. and Lee, Y.A.
Nature Communications 8 (1): 1056. 20 October 2017

A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction.
Bowl, M.R., Simon, M.M., Ingham, N.J., Greenaway, S., Santos, L., Cater, H., Taylor, S., Mason, J., Kurbatova, N., Pearson, S., Bower, L.R., Clary, D.A., Meziane, H., Reilly, P., Minowa, O., Kelsey, L., Tocchini-Valentini, G.P., Gao, X., Bradley, A., Skarnes, W.C., Moore, M., Beaudet, A.L., Justice, M.J., Seavitt, J., Dickinson, M.E., Wurst, W., Hrabe de Angelis, M., Herault, Y., Wakana, S., Nutter, L.M.J., Flenniken, A.M., McKerlie, C., Murray, S.A., Svenson, K.L., Braun, R.E., West, D.B., Lloyd, K.C.K., Adams, D.J., White, J., Karp, N., Flicek, P., Smedley, D., Meehan, T.F., Parkinson, H.E., Teboul, L.M., Wells, S., Steel, K.P., Mallon, A.M. and Brown, S.D.M.
Nature Communications 8 (1): 886. 12 October 2017

Activating de novo mutations in NFE2L2 encoding NRF2 cause a multisystem disorder.
Huppke, P., Weissbach, S., Church, J.A., Schnur, R., Krusen, M., Dreha-Kulaczewski, S., Kühn-Velten, W.N., Wolf, A., Huppke, B., Millan, F., Begtrup, A., Almusafri, F., Thiele, H., Altmüller, J., Nürnberg, P., Müller, M. and Gärtner, J.
Nature Communications 8 (1): 818. 10 October 2017

RNA localization is a key determinant of neurite-enriched proteome.
Zappulo, A., van den Bruck, D., Ciolli Mattioli, C., Franke, V., Imami, K., McShane, E., Moreno-Estelles, M., Calviello, L., Filipchyk, A., Peguero-Sanchez, E., Müller, T., Woehler, A., Birchmeier, C., Merino, E., Rajewsky, N., Ohler, U., Mazzoni, E.O., Selbach, M., Akalin, A. and Chekulaeva, M.
Nature Communications 8 (1): 583. 19 September 2017

Retinol saturase coordinates liver metabolism by regulating ChREBP activity.
Heidenreich, S., Witte, N., Weber, P., Goehring, I., Tolkachov, A., von Loeffelholz, C., Döcke, S., Bauer, M., Stockmann, M., Pfeiffer, A.F.H., Birkenfeld, A.L., Pietzke, M., Kempa, S., Muenzner, M. and Schupp, M.
Nature Communications 8 (1): 384. 30 August 2017

The endothelial transcription factor ERG mediates angiopoietin-1-dependent control of notch signalling and vascular stability.
Shah, A.V., Birdsey, G.M., Peghaire, C., Pitulescu, M.E., Dufton, N.P., Yang, Y., Weinberg, I., Osuna Almagro, L., Payne, L., Mason, J.C., Gerhardt, H., Adams, R.H. and Randi, A.M.
Nature Communications 8 : 16002. 11 July 2017

Flipping between Polycomb repressed and active transcriptional states introduces noise in gene expression.
Kar, G., Kim, J.K., Kolodziejczyk, A.A., Natarajan, K.N., Torlai Triglia, E., Mifsud, B., Elderkin, S., Marioni, J.C., Pombo, A. and Teichmann, S.A.
Nature Communications 8 (1): 36. 26 June 2017

Identification of the elementary structural units of the DNA damage response.
Natale, F., Rapp, A., Yu, W., Maiser, A., Harz, H., Scholl, A., Grulich, S., Anton, T., Hoerl, D., Chen, W., Durante, M., Taucher-Scholz, G., Leonhardt, H. and Cardoso, M.C.
Nature Communications 8 : 15760. 12 June 2017

Regulated membrane remodeling by Mic60 controls formation of mitochondrial crista junctions.
Hessenberger, M., Zerbes, R.M., Rampelt, H., Kunz, S., Xavier, A.H., Purfürst, B., Lilie, H., Pfanner, N., van der Laan, M. and Daumke, O.
Nature Communications 8 : 15258. 31 May 2017

Proteogenomic integration reveals therapeutic targets in breast cancer xenografts.
Huang, K.L., Li, S., Mertins, P., Cao, S., Gunawardena, H.P., Ruggles, K.V., Mani, D.R., Clauser, K.R., Tanioka, M., Usary, J., Kavuri, S.M., Xie, L., Yoon, C., Qiao, J.W., Wrobel, J., Wyczalkowski, M.A., Erdmann-Gilmore, P., Snider, J.E., Hoog, J., Singh, P., Niu, B., Guo, Z., Sun, S.Q., Sanati, S., Kawaler, E., Wang, X., Scott, A., Ye, K., McLellan, M.D., Wendl, M.C., Malovannaya, A., Held, J.M., Gillette, M.A., Fenyö, D., Kinsinger, C.R., Mesri, M., Rodriguez, H., Davies, S.R., Perou, C.M., Ma, C., Townsend, R.R., Chen, X., Carr, S.A., Ellis, M.J. and Ding, L.
Nature Communications 8 : 14864. 28 March 2017

Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2.
Cerdá-Esteban, N., Naumann, H., Ruzittu, S., Mah, N., Pongrac, I.M., Cozzitorto, C., Hommel, A., Andrade-Navarro, M.A., Bonifacio, E. and Spagnoli, F.M.
Nature Communications 8 : 14127. 13 February 2017

Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors.
Schütte, M., Risch, T., Abdavi-Azar, N., Boehnke, K., Schumacher, D., Keil, M., Yildiriman, R., Jandrasits, C., Borodina, T., Amstislavskiy, V., Worth, C.L., Schweiger, C., Liebs, S., Lange, M., Warnatz, H.J., Butcher, L.M., Barrett, J.E., Sultan, M., Wierling, C., Golob-Schwarzl, N., Lax, S., Uranitsch, S., Becker, M., Welte, Y., Regan, J.L., Silvestrov, M., Kehler, I., Fusi, A., Kessler, T., Herwig, R., Landegren, U., Wienke, D., Nilsson, M., Velasco, J.A., Garin-Chesa, P., Reinhard, C., Beck, S., Schäfer, R., Regenbrecht, C.R.A., Henderson, D., Lange, B., Haybaeck, J., Keilholz, U., Hoffmann, J., Lehrach, H. and Yaspo, M.L.
Nature Communications 8 : 14262. 10 February 2017

DNA copy number changes define spatial patterns of heterogeneity in colorectal cancer.
Mamlouk, S., Childs, L.H., Aust, D., Heim, D., Melching, F., Oliveira, C., Wolf, T., Durek, P., Schumacher, D., Blaeker, H., von Winterfeld, M., Gastl, B., Moehr, K., Menne, A., Zeugner, S., Redmer, T., Lenze, D., Tierling, S., Moebs, M., Weichert, W., Folprecht, G., Blanc, E., Beule, D., Schaefer, R., Morkel, M., Klauschen, F., Leser, U. and Sers, C.
Nature Communications 8 : 14093. 25 January 2017

2016

How EF-Tu can contribute to efficient proofreading of aa-tRNA by the ribosome.
Noel, J.K. and Whitford, P.C.
Nature Communications 7 : 13314. 31 October 2016

Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers.
Arumughan, A., Roske, Y., Barth, C., Lleras Forero, L., Bravo-Rodriguez, K., Redel, Al., Kostova, S., McShane, E., Opitz, R., Faelber, K., Rau, K., Mielke, T., Daumke, O., Selbach, M., Sanchez-Garcia, E., Rocks, O., Panáková, D., Heinemann, U. and Wanker, E.E.
Nature Communications 7 : 13047. 20 October 2016

Bimodal antagonism of PKA signalling by ARHGAP36.
Eccles, R.L., Czajkowski, M.T., Barth, C., Müller, P.M., McShane, E., Grunwald, S., Beaudette, P., Mecklenburg, N., Volkmer, R., Zühlke, K., Dittmar, G., Selbach, M., Hammes, A., Daumke, O., Klussmann, E., Urbé, S. and Rocks, O.
Nature Communications 7 : 12963. 7 October 2016

Integrative proteomic profiling of ovarian cancer cell lines reveals precursor cell associated proteins and functional status.
Coscia, F., Watters, K.M., Curtis, M., Eckert, M.A., Chiang, C.Y., Tyanova, S., Montag, A., Lastra, R.R., Lengyel, E. and Mann, M.
Nature Communications 7 : 12645. 26 August 2016

reChIP-seq reveals widespread bivalency of H3K4me3 and H3K27me3 in CD4(+) memory T cells.
Kinkley, S., Helmuth, J., Polansky, J.K., Dunkel, I., Gasparoni, G., Froehler, S., Chen, W., Walter, J., Hamann, A. and Chung, H.R.
Nature Communications 7 : 12514. 17 August 2016

Glycolytic regulation of cell rearrangement in angiogenesis.
Cruys, B., Wong, B.W., Kuchnio, A., Verdegem, D., Cantelmo, A. R., Conradi, L.C., Vandekeere, S., Bouché, A., Cornelissen, I., Vinckier, S., Merks, R.M.H., Dejana, E., Gerhardt, H., Dewerchin, M., Bentley, K. and Carmeliet, P.
Nature Communications 7 : 12240. 20 July 2016

Disruption of Kcc2-dependent inhibition of olfactory bulb output neurons suggests its importance in odour discrimination.
Gödde, K., Gschwend, O., Puchkov, D., Pfeffer, C.K., Carleton, A. and Jentsch, T.J.
Nature Communications 7 : 12043. 8 July 2016

Wars2 is a determinant of angiogenesis.
Wang, M., Sips, P., Khin, E., Rotival, M., Sun, X., Ahmed, R., Widjaja, A.A., Schafer, S., Yusoff, P., Choksi, Pe.K., Ko, N.S.J., Singh, M.K., Epstein, D., Guan, Y., Houštěk, J., Mracek, T., Nuskova, H., Mikell, B., Tan, J., Pesce, F., Kolar, F., Bottolo, L., Mancini, M., Hubner, N., Pravenec, M., Petretto, E., MacRae, C. and Cook, S.A.
Nature Communications 7 : 12061. 8 July 2016

Deficient methylation and formylation of mt-tRNA(Met) wobble cytosine in a patient carrying mutations in NSUN3.
Van Haute, L., Dietmann, S., Kremer, L., Hussain, S., Pearce, S.F., Powell, C.A., Rorbach, J., Lantaff, R., Blanco, S., Sauer, S., Kotzaeridou, U., Hoffmann, G.F., Memari, Y., Kolb-Kokocinski, A., Durbin, R., Mayr, J.A., Frye, M., Prokisch, H. and Minczuk, M.
Nature Communications 7 : 12039. 30 June 2016

Foldamer-mediated manipulation of a pre-amyloid toxin.
Kumar, S., Birol, M., Schlamadinger, D.E., Wojcik, S.P., Rhoades, E. and Miranker, A.D.
Nature Communications 7 : 11412. 25 April 2016

Energy efficiency trade-offs drive nucleotide usage in transcribed regions.
Chen, W.H., Lu, G., Bork, P., Hu, S. and Lercher, M.J.
Nature Communications 7 : 11334. 21 April 2016

4D visualization of replication foci in mammalian cells corresponding to individual replicons.
Chagin, V.O., Casas-Delucchi, C.S., Reinhart, M., Schermelleh, L., Markaki, Y., Maiser, A., Bolius, J.J., Bensimon, A., Fillies, M., Domaing, P., Rozanov, Y.M., Leonhardt, H. and Cardoso, M.C.
Nature Communications 7 : 11231. 7 April 2016

Serial interactome capture of the human cell nucleus.
Conrad, T., Albrecht, A.-S., Rodrigues de Melo Costa, V., Sauer, S., Meierhofer, D. and Ørom, U.A.
Nature Communications 7 : 11212. 4 April 2016

Sleeping Beauty transposase structure allows rational design of hyperactive variants for genetic engineering.
Voigt, F., Wiedemann, L., Zuliani, C., Querques, I., Sebe, A., Mátés, L., Izsvák, Z., Ivics, Z. and Barabas, O.
Nature Communications 7 : 11126. 30 March 2016

Cyanobacterial symbionts diverged in the late Cretaceous towards lineage-specific nitrogen fixation factories in single-celled phytoplankton.
Cornejo-Castillo, F.M., Cabello, A.M., Salazar, G., Sanchez-Baracaldo, P., Lima-Mendez, G., Hingamp, P., Alberti, A., Sunagawa, S., Bork, P., de Vargas, C., Raes, J., Bowler, C., Wincker, P., Zehr, J.P., Gasol, J.M., Massana, R. and Acinas, S.G.
Nature Communications 7 : 11071. 22 March 2016

A Helitron transposon reconstructed from bats reveals a novel mechanism of genome shuffling in eukaryotes.
Grabundzija, I., Messing, S.A., Thomas, J., Cosby, R.L., Bilic, I., Miskey, C., Gogol-Döring, A., Kapitonov, V., Diem, T., Dalda, A., Jurka, J., Pritham, E.J., Dyda, F., Izsvák, Z. and Ivics, Z.
Nature Communications 7 : 10716. 2 March 2016

Intestinal microbiome is related to lifetime antibiotic use in Finnish pre-school children.
Korpela, K., Salonen, A., Virta, L.J., Kekkonen, R.A., Forslund, K., Bork, P. and de Vos, W.M.
Nature Communications 7 : 10410. 26 January 2016

Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells.
Klawitter, S., Fuchs, N.V., Upton, K.R., Muñoz-Lopez, M., Shukla, R., Wang, J., Garcia-Cañadas, M., Lopez-Ruiz, C., Gerhardt, D.J., Sebe, A., Grabundzija, I., Merkert, S., Gerdes, P., Pulgarin, J.A., Bock, A., Held, U., Witthuhn, A., Haase, A., Sarkadi, B., Löwer, J., Wolvetang, E.J., Martin, U., Ivics, Z., Izsvák, Z., Garcia-Perez, J.L., Faulkner, G.J. and Schumann, G.G.
Nature Communications 7 : 10286. 8 January 2016

2015

Structure of a bacterial type III secretion system in contact with a host membrane in situ.
Nans, A., Kudryashev, M., Saibil, H.R. and Hayward, R.D.
Nature Communications 6 : 10114. 11 December 2015

Cold-aggravated pain in humans caused by a hyperactive Na(V)1.9 channel mutant.
Leipold, E., Hanson-Kahn, A., Frick, M., Gong, P., Bernstein, J.A., Voigt, M., Katona, I., Oliver Goral, R., Altmüller, J., Nürnberg, P., Weis, J., Hübner, C.A., Heinemann, S.H. and Kurth, I.
Nature Communications 6 : 10049. 8 December 2015

Meta-analysis identifies seven susceptibility loci involved in the atopic march.
Marenholz, I., Esparza-Gordillo, J., Rüschendorf, F., Bauerfeind, A., Strachan, D.P., Spycher, B.D., Baurecht, H., Margaritte-Jeannin, P., Sääf, A., Kerkhof, M., Ege, M., Baltic, S., Matheson, M.C., Li, J., Michel, S., Ang, W.Q., McArdle, W., Arnold, A., Homuth, G., Demenais, F., Bouzigon, E., Söderhäll, C., Pershagen, G., de Jongste, J.C., Postma, D.S., Braun-Fahrlaender, C., Horak, E., Ogorodova, L.M., Puzyrev, V.P., Bragina, E.Y., Hudson, T.J., Morin, C., Duffy, D.L., Marks, G.B., Robertson, C.F., Montgomery, G.W., Musk, B., Thompson, P.J., Martin, N.G., James, A., Sleiman, P., Toskala, E., Rodriguez, E., Fölster-Holst, R., Franke, A., Lieb, W., Gieger, C., Heinzmann, A., Rietschel, E., Keil, T., Cichon, S., Nöthen, M.M., Pennell, C.E., Sly, P.D., Schmidt, C.O., Matanovic, A., Schneider, V., Heinig, M., Hübner, N., Holt, P.G., Lau, S., Kabesch, M., Weidinger, S., Hakonarson, H., Ferreira, M.A.R., Laprise, C., Freidin, M.B., Genuneit, J., Koppelman, G.H., Melén, E., Dizier, M.H., Henderson, A.J. and Lee, Y.A.
Nature Communications 6 : 8804. 6 November 2015

Stonin1 mediates endocytosis of the proteoglycan NG2 and regulates focal adhesion dynamics and cell motility.
Feutlinske, F., Browarski, M., Ku, M.C., Trnka, P., Waiczies, S., Niendorf, T., Stallcup, W.B., Glass, R., Krause, E. and Maritzen, T.
Nature Communications 6 : 8535. 5 October 2015

Diffusional spread and confinement of newly exocytosed synaptic vesicle proteins.
Gimber, N., Tadeus, G., Maritzen, T., Schmoranzer, J. and Haucke, V.
Nature Communications 6 : 8392. 24 September 2015

Chamber identity programs drive early functional partitioning of the heart.
Mosimann, C., Panáková, D., Werdich, A.A., Musso, G., Burger, A., Lawson, K.L., Carr, L.A., Nevis, K.R., Sabeh, M.K, Zhou, Y., Davidson, A.J., DiBiase, A., Burns, C.E., Burns, C.G., MacRae, C.A. and Zon, L.I.
Nature Communications 6 : 8146. 26 August 2015

PTEN mediates Notch-dependent stalk cell arrest in angiogenesis.
Serra, H., Chivite, I., Angulo-Urarte, A., Soler, A., Sutherland, J.D., Arruabarrena-Aristorena, A., Ragab, A., Lim, R., Malumbres, M., Fruttiger, M., Potente, M., Serrano, M., Fabra, A., Vinals, F., Casanovas, O., Pandolfi, P.P., Bigas, A., Carracedo, A., Gerhardt, H. and Graupera, M.
Nature Communications 6 : 7935. 31 July 2015

RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway.
Murakawa, Y., Hinz, M., Mothes, J., Schuetz, A., Uhl, M., Wyler, E., Yasuda, T., Mastrobuoni, G., Friedel, C.C., Dölken, L., Kempa, S., Schmidt-Supprian, M., Blüthgen, N., Backofen, R., Heinemann, U., Wolf, J., Scheidereit, C. and Landthaler, M.
Nature Communications 6 : 7367. 14 July 2015

Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch.
Aspalter, I.M., Gordon, E., Dubrac, A., Ragab, A., Narloch, J., Vizán, P., Geudens, I., Collins, R.T., Franco, C.A., Abrahams, C.L., Thurston, G., Fruttiger, M., Rosewell, I., Eichmann, A. and Gerhardt, H.
Nature Communications 6 : 7264. 17 June 2015

Translational regulation shapes the molecular landscape of complex disease phenotypes.
Schafer, S., Adami, E., Heinig, M., Costa Rodrigues, K.E., Kreuchwig, F., Silhavy, J., van Heesch, S., Simaite, D., Rajewsky, N., Cuppen, E., Pravenec, M., Vingron, M., Cook, S.A. and Hubner, N.
Nature Communications 6 : 7200. 26 May 2015

Photoswitchable fatty acids enable optical control of TRPV1.
Frank, J.A., Moroni, M., Moshourab, R., Sumser, M., Lewin, G.R. and Trauner, D.
Nature Communications 6 : 7118. 21 May 2015

eQTL mapping identifies insertion- and deletion-specific eQTLs in multiple tissues.
Huang, J., Chen, J., Esparza, J., Ding, J., Elder, J.T., Abecasis, G.R., Lee, Y.A., Lathrop, G.M., Moffatt, M.F., Cookson, W.O.C. and Liang, L.
Nature Communications 6 : 6821. 8 May 2015

KCNQ5 K(+) channels control hippocampal synaptic inhibition and fast network oscillations.
Fidzinski, P., Korotkova, T., Heidenreich, M., Maier, N., Schuetze, S., Kobler, O., Zuschratter, W., Schmitz, D., Ponomarenko, A. and Jentsch, T.J.
Nature Communications 6 : 6254. 4 February 2015

2014

Roquin binding to target mRNAs involves a winged helix-turn-helix motif.
Schuetz, A., Murakawa, Y., Rosenbaum, E., Landthaler, M. and Heinemann, U.
Nature Communications 5 : 5701. 11 December 2014

Chlamydia infection depends on a functional MDM2-p53 axis.
Gonzalez, E., Rother, M., Kerr, M.C., Al-Zeer, M.A., Abu-Lubad, M., Kessler, M., Brinkmann, V., Loewer, A. and Meyer, T.F.
Nature Communications 5 : 5201. 13 November 2014

Dendritic cell-mediated survival signals in Eμ-Myc B-cell lymphoma depend on the transcription factor C/EBPβ.
Rehm, A., Gätjen, M., Gerlach, K., Scholz, F., Mensen, A., Gloger, M., Heinig, K., Lamprecht, B., Mathas, S., Bégay, V., Leutz, A., Lipp, M., Dörken, B. and Höpken, U.E.
Nature Communications 5 : 5057. 30 September 2014

Warped linear mixed models for the genetic analysis of transformed phenotypes.
Fusi, N., Lippert, C., Lawrence, N.D. and Stegle, O.
Nature Communications 5 : 4890. 19 September 2014

AmotL2 disrupts apical-basal cell polarity and promotes tumour invasion.
Mojallal, M., Zheng, Y., Hultin, S., Audebert, S., van Harn, T., Johnsson, P., Lenander, C., Fritz, N., Mieth, C., Corcoran, M., Lembo, F., Hallstroem, M., Hartman, J., Mazure, N.M., Weide, T., Grander, D., Borg, J.P., Uhlen, P. and Holmgren, L.
Nature Communications 5 : 4557. 1 August 2014

WT1 controls antagonistic FGF and BMP-pSMAD pathways in early renal progenitors.
Motamedi, F.J., Badro, D.A., Clarkson, M., Rita Lecca, M., Bradford, S.T., Buske, F.A., Saar, K., Hübner, N., Bräendli, A.W. and Schedl, A.
Nature Communications 5 : 4444. 17 July 2014

MRTF-A controls vessel growth and maturation by increasing the expression of CCN1 and CCN2.
Hinkel, R., Trenkwalder, T., Petersen, B., Husada, W., Gesenhues, F., Lee, S., Hannappel, E., Bock-Marquette, I., Theisen, D., Leitner, L., Boekstegers, P., Cierniewski, C., Mueller, O.J., le Noble, F., Adams, R.H., Weinl, C., Nordheim, A., Reichart, B., Weber, C., Olson, E., Posern, G., Deindl, E., Niemann, H. and Kupatt, C.
Nature Communications 5 : 3970. 9 June 2014

Transplanted terminally differentiated induced pluripotent stem cells are accepted by immune mechanisms similar to self-tolerance.
de Almeida, P.E., Meyer, E.H., Kooreman, N.G., Diecke, S., Dey, D., Sanchez-Freire, V., Hu, S., Ebert, A., Odegaard, J., Mordwinkin, N.M., Brouwer, T.P., Lo, D., Montoro, D.T., Longaker, M.T., Negrin, R.S. and Wu, J.C.
Nature Communications 5 : 3903. 30 May 2014

Klf4 and Klf5 differentially inhibit mesoderm and endoderm differentiation in embryonic stem cells.
Aksoy, I., Giudice, V., Delahaye, E., Wianny, F., Aubry, M., Mure, M., Chen, J., Jauch, R., Bogu, G.K., Nolden, T., Himmelbauer, H., Doss, M.X., Sachinidis, A., Schulz, H., Hummel, O., Martinelli, P., Hübner, N., Stanton, L.W., Real, F.X., Bourillot, P.Y. and Savatier, P.
Nature Communications 5 : 3719. 28 April 2014

Frequent mutations in chromatin-remodelling genes in pulmonary carcinoids.
Fernandez-Cuesta, L., Peifer, M., Lu, X., Sun, R., Ozretić, L., Seidal, D., Zander, T., Leenders, F., George, J., Müller, C., Dahmen, I., Pinther, B., Bosco, G., Konrad, K., Altmüller, J., Nürnberg, P., Achter, V., Lang, U., Schneider, P.M., Bogus, M., Soltermann, A., Brustugun, O.T., Helland, Å., Solberg, S., Lund-Iversen, M., Ansén, S., Stoelben, E., Wright, G.M., Russell, P., Wainer, Z., Solomon, B., Field, J.K., Hyde, R., Davies, M.P., Heukamp, L.C., Petersen, I., Perner, S., Lovly, C., Cappuzzo, F., Travis, W.D., Wolf, J., Vingron, M., Brambilla, E., Haas, S.A., Buettner, R. and Thomas, R.K.
Nature Communications 5 : 3518. 27 March 2014

Mutations in epigenetic regulators including SETD2 are gained during relapse in paediatric acute lymphoblastic leukaemia.
Mar, B.G., Bullinger, L.B., McLean, K.M., Grauman, P.V., Harris, M.H., Stevenson, K., Neuberg, D.S., Sinha, A.U., Sallan, S.E., Silverman, L.B., Kung, A.L., Lo Nigro, L., Ebert, B.L. and Armstrong, S.A.
Nature Communications 5 : 3469. 24 March 2014

Tuning piezo ion channels to detect molecular-scale movements relevant for fine touch.
Poole, K., Herget, R., Lapatsina, L., Ngo, H.D. and Lewin, G.R.
Nature Communications 5 : 3520. 24 March 2014

Disrupting MLC1 and GlialCAM and ClC-2 interactions in leukodystrophy entails glial chloride channel dysfunction.
Hoegg-Beiler, M.B., Sirisi, S., Orozco, I.J., Ferrer, I., Hohensee, S., Auberson, M., Goedde, K., Vilches, C., de Heredia, M.L., Nunes, V., Estévez, R. and Jentsch, T.J.
Nature Communications 5 : 3475. 19 March 2014

2013

Role of RIM1α in short- and long-term synaptic plasticity at cerebellar parallel fibres.
Kintscher, M., Wozny, C., Johenning, F.W., Schmitz, D. and Breustedt, J.
Nature Communications 4 : 2392. 3 September 2013

Translation of HTT mRNA with expanded CAG repeats is regulated by the MID1-PP2A protein complex.
Krauss, S., Griesche, N., Jastrzebska, E., Chen, C., Rutschow, D., Achmüller, C., Dorn, S., Boesch, S.M., Lalowski, M., Wanker, E., Schneider, R. and Schweiger, S.
Nature Communications 4 : 1511. 26 February 2013

A chronic model of arthritis supported by a strain-specific periarticular lymph node in BALB/c mice.
Baddack, U., Hartmann, S., Bang, H., Grobe, J., Loddenkemper, C., Lipp, M. and Mueller, G.
Nature Communications 4 : 1644. 2013

A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiple polyglutamine diseases.
Fujita, K., Nakamura, Y., Oka, T., Ito, H., Tamura, T., Tagawa, K., Sasabe, T., Katsuta, A., Motoki, K., Shiwaku, H., Sone, M., Yoshida, C., Katsuno, M., Eishi, Y., Murata, M., Taylor, J.P., Wanker, E.E., Kono, K., Tashiro, S., Sobue, G., La Spada, A.R. and Okazawa, H.
Nature Communications 4 : 1816. 2013

2011

Backbone rigidity and static presentation of guanidinium groups increases cellular uptake of arginine-rich cell-penetrating peptides.
Lättig-Tünnemann, G., Prinz, M., Hoffmann, D., Behlke, J., Palm-Apergi, C., Morano, I., Herce, H.D. and Cardoso, M.C.
Nature Communications 2 : 453. 30 August 2011

Histone acetylation controls the inactive X chromosome replication dynamics.
Casas-Delucchi, C.S., Brero, A., Rahn, H.P., Solovei, I., Wutz, A., Cremer, T., Leonhardt, H. and Cardoso, M.C.
Nature Communications 2 (1): 222. March 2011

Differential use of importin-alpha isoforms governs cell tropism and host adaptation of influenza virus.
Gabriel, G., Klingel, K., Otte, A., Thiele, S., Hudjetz, B., Arman-Kalcek, G., Sauter, M., Shmidt, T., Rother, F., Baumgarte, S., Keiner, B., Hartmann, E., Bader, M., Brownlee, G.G., Fodor, E. and Klenk, H.D.
Nature Communications 2 (1): 156. January 2011