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2018

Mutations in disordered regions can cause disease by creating dileucine motifs.
Meyer, K. and Kirchner, M. and Uyar, B. and Cheng, J.Y. and Russo, G. and Hernandez-Miranda, L.R. and Szymborska, A. and Zauber, H. and Rudolph, I.M. and Willnow, T.E. and Akalin, A. and Haucke, V. and Gerhardt, H. and Birchmeier, C. and Kühn, R. and Krauss, M. and Diecke, S. and Pascual, J.M. and Selbach, M.
Cell 6 September 2018 (In Press)

Single-cell transcriptomics characterizes cell types in the subventricular zone and uncovers molecular defects underlying impaired adult neurogenesis.
Zywitza, V. and Misios, A. and Bunatyan, L. and Willnow, T.E. and Rajewsky, N.
bioRxiv : 365619. 9 July 2018

SORCS1 and SORCS3 control energy balance and orexigenic peptide production.
Subkhangulova, A. and Malik, A.R. and Hermey, G. and Popp, O. and Dittmar, G. and Rathjen, T. and Poy, M.N. and Stumpf, A. and Beed, P.S. and Schmitz, D. and Breiderhoff, T. and Willnow, T.E.
EMBO Reports 19 (4): e44810. 1 April 2018

Deletion of claudin-10 rescues claudin-16-deficient mice from hypomagnesemia and hypercalciuria.
Breiderhoff, T. and Himmerkus, N. and Drewell, H. and Plain, A. and Guenzel, D. and Mutig, K. and Willnow, T.E. and Müller, D. and Bleich, M.
Kidney International 93 (3): 580-588. March 2018

Cadm2 regulates body weight and energy homeostasis in mice.
Yan, X. and Wang, Z. and Schmidt, V. and Gauert, A. and Willnow, T.E. and Heinig, M. and Poy, M.N.
Molecular Metabolism 8 : 180-188. February 2018

Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA.
Eggert, S. and Gonzalez, A.C. and Thomas, C. and Schilling, S. and Schwarz, S.M. and Tischer, C. and Adam, V. and Strecker, P. and Schmidt, V. and Willnow, T.E. and Hermey, G. and Pietrzik, C.U. and Koo, E.H. and Kins, Stefan
Cellular and Molecular Life Sciences 75 (2): 301-322. January 2018

2017

SORLA attenuates EphA4 signaling and amyloid, β-induced neurodegeneration.
Huang, T.Y. and Zhao, Y. and Jiang, L.L. and Li, X. and Liu, Y. and Sun, Y. and Piña-Crespo, J.C. and Zhu, B. and Masliah, E. and Willnow, T.E. and Pasquale, E.B. and Xu, H.
Journal of Experimental Medicine 214 (12): 3669-3685. 4 December 2017

Endocytic receptor LRP2/megalin-of holoprosencephaly and renal Fanconi syndrome.
Willnow, T.E. and Christ, A.
Pflugers Archiv 469 (7-8): 907-916. August 2017

Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1.
Rathjen, T. and Yan, X. and Kononenko, N.L. and Ku, M.C. and Song, K. and Ferrarese, L. and Tarallo, V. and Puchkov, D. and Kochlamazashvili, G. and Brachs, S. and Varela, L. and Szigeti-Buck, K. and Yi, C.X. and Schriever, S.C. and Tattikota, S.G. and Carlo, A.S. and Moroni, M. and Siemens, J. and Heuser, A. and van der Weyden, L. and Birkenfeld, A.L. and Niendorf, T. and Poulet, J.F.A. and Horvath, T.L. and Tschöp, M.H. and Heinig, M. and Trajkovski, M. and Haucke, V. and Poy, M.N.
Nature Neuroscience 20 (8): 1096-1103. August 2017

Impaired vitreous composition and retinal pigment epithelium function in the FoxG1::LRP2 myopic mice.
Cases, O. and Obry, A. and Ben-Yacoub, S. and Augustin, S. and Joseph, A. and Toutirais, G. and Simonutti, M. and Christ, A. and Cosette, P. and Kozyraki, R.
Biochimica et Biophysica Acta - Molecular Cell Research 1863 (6): 1242-1254. June 2017

Nanotubes, the fast track to treatment of Dent disease?
Willnow, T.E.
Kidney International 91 (4): 776-778. April 2017

Sorting receptor SORLA: cellular mechanisms and implications for disease.
Schmidt, V. and Subkhangulova, A. and Willnow, T.E.
Cellular and Molecular Life Sciences 74 (8): 1475-1483. April 2017

2016

SorCS2 is required for BDNF-dependent plasticity in the hippocampus.
Glerup, S. and Bolcho, U. and Molgaard, S. and Bøggild, S. and Vaegter, C.B. and Smith, A.H. and Nieto-Gonzalez, J.L. and Ovesen, P.L. and Pedersen, L.F. and Fjorback, A.N. and Kjolby, M. and Login, H. and Holm, M.M. and Andersen, O.M. and Nyengaard, J.R. and Willnow, T.E. and Jensen, K. and Nykjaer, A.
Molecular Psychiatry 21 (12): 1740-1751. December 2016

Risk factor SORL1: from genetic association to functional validation in Alzheimer's disease.
Andersen, O.M. and Rudolph, I.M. and Willnow, T.E.
Acta Neuropathologica 132 (5): 653-665. November 2016

Sortilin regulates sorting and secretion of Sonic hedgehog.
Campbell, C. and Beug, S. and Nickerson, P.E.B. and Peng, J. and Mazerolle, C. and Bassett, E. and Ringuette, R. and Jama, F.A. and Morales, C. and Christ, A. and Wallace, V.A.
Journal of Cell Science 129 (20): 3832-3844. 15 October 2016

Identification of novel regulators of developmental hematopoiesis using endoglin regulatory elements as molecular probes.
Nasrallah, R. and Fast, E.M. and Solaimani, P. and Knezevic, K. and Eliades, A. and Patel, R. and Thambyrajah, R. and Unnikrishnan, A. and Thoms, J. and Beck, D. and Vink, C.S. and Smith, A. and Wong, J. and Shepherd, M. and Kent, D. and Roychoudhuri, R. and Paul, F. and Klippert, J. and Hammes, A. and Willnow, T. and Göttgens, B. and Dzierzak, E. and Zon, L.I. and Lacaud, G. and Kouskoff, V. and Pimanda, J.E.
Blood 128 (15): 1928-1939. 13 October 2016

SORLA regulates calpain-dependent degradation of synapsin.
Hartl, D. and Nebrich, G. and Klein, O. and Stephanowitz, H. and Krause, E. and Rohe, M.
Alzheimer's & Dementia 12 (9): 952-963. September 2016

SNX27 and SORLA interact to reduce amyloidogenic subcellular distribution and processing of amyloid precursor protein.
Huang, T.Y. and Zhao, Y. and Li, X. and Wang, X. and Tseng, I.C. and Thompson, R. and Tu, S. and Willnow, T.E. and Zhang, Y.W. and Xu, H.
Journal of Neuroscience 36 (30): 7996-8011. 27 July 2016

SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity.
Schmidt, V. and Schulz, N. and Yan, X. and Schürmann, A. and Kempa, S. and Kern, M. and Blüher, M. and Poy, M.N. and Olivecrona, G. and Willnow, T.E.
Journal of Clinical Investigation 126 (7): 2706-2720. 1 July 2016

LRP2, an auxiliary receptor that controls sonic hedgehog signaling in development and disease.
Christ, A. and Herzog, K. and Willnow, T.E.
Developmental Dynamics 245 (5): 569-579. May 2016

Protein sorting gone wrong - VPS10P domain receptors in cardiovascular and metabolic diseases.
Schmidt, V. and Willnow, T.E.
Atherosclerosis 245 : 194-199. February 2016

Calcineurin and sorting-related receptor with A-type repeats interact to regulate the renal Na(+)-K(+)-2Cl(-) cotransporter.
Borschewski, A. and Himmerkus, N. and Boldt, C. and Blankenstein, K.I. and McCormick, J.A. and Lazelle, R. and Willnow, T.E. and Jankowski, V. and Plain, A. and Bleich, M. and Ellison, D.H. and Bachmann, S. and Mutig, K.
Journal of the American Society of Nephrology 27 (1): 107-119. January 2016

2015

Role of sortilin in models of autoimmune neuroinflammation.
Reuter, E. and Weber, J. and Paterka, M. and Ploen, R. and Breiderhoff, T. and van Horssen, J. and Willnow, T.E. and Siffrin, V. and Zipp, F.
Journal of Immunology 195 (12): 5762-5769. 15 December 2015

LRP2 acts as SHH clearance receptor to protect the retinal margin from mitogenic stimuli.
Christ, A. and Christa, A. and Klippert, J. and Eule, J.C. and Bachmann, S. and Wallace, V.A. and Hammes, A. and Willnow, T.E.
Developmental Cell 35 (1): 36-48. 12 October 2015

Distinct functions for anterograde and retrograde sorting of SORLA in amyloidogenic processes in the brain.
Dumanis, S.B. and Burgert, T. and Caglayan, S. and Füchtbauer, A. and Füchtbauer, E.M. and Schmidt, V. and Willnow, T.E.
Journal of Neuroscience 35 (37): 12703-12713. 16 September 2015

Lrp1/LDL receptor play critical roles in mannose 6-phosphate-independent lysosomal enzyme targeting.
Markmann, S. and Thelen, M. and Cornils, K. and Schweizer, M. and Brocke-Ahmadinejad, N. and Willnow, T. and Heeren, J. and Gieselmann, V. and Braulke, T. and Kollmann, K.
Traffic 16 (7): 743-759. July 2015

Foxg1-Cre mediated Lrp2 inactivation in the developing mouse neural retina, ciliary and retinal pigment epithelia models congenital high myopia.
Cases, O. and Joseph, A. and Obry, A. and Santin, M.D. and Ben-Yacoub, S. and Paques, M. and Amsellem-Levera, S. and Bribian, A. and Simonutti, M. and Augustin, S. and Debeir, T. and Sahel, J.A. and Christ, A. and de Castro, F. and Lehericy, S. and Cosette, P. and Kozyraki, R.
PLoS ONE 10 (6): e0129518. 24 June 2015

Very low density lipoprotein receptor regulates dendritic spine formation in a RasGRF1/CaMKII dependent manner.
DiBattista, A.M. and Dumanis, S.B. and Song, J.M. and Bu, G. and Weeber, E. and Rebeck, G.W. and Hoe, H.S.
Biochimica et Biophysica Acta - Molecular Cell Research 1853 (5): 904-917. May 2015

Novel codon-optimized mini-intronic plasmid for efficient, inexpensive, and xeno-free induction of pluripotency.
Diecke, S. and Lu, J. and Lee, J. and Termglinchan, V. and Kooreman, N.G. and Burridge, P.W. and Ebert, A.D. and Churko, J.M. and Sharma, A. and Kay, M.A. and Wu, J.C.
Scientific Reports 5 : 8081. 28 January 2015

2014

Growth and differentiation factor 10 (Gdf10) is involved in Bergmann glial cell development under Shh regulation.
Mecklenburg, N. and Martinez-Lopez, J.E. and Moreno-Bravo, J.A. and Perez-Balaguer, A. and Puelles, E. and Martinez, S.
Glia 62 (10): 1713-1723. October 2014

Sorting receptor sortilin-a culprit in cardiovascular and neurological diseases.
Carlo, A.S. and Nykjaer, A. and Willnow, T.E.
Journal of Molecular Medicine 92 (9): 905-911. September 2014

Disturbed function of the blood-cerebrospinal fluid barrier aggravates neuro-inflammation.
Kooij, G. and Kopplin, K. and Blasig, R. and Stuiver, M. and Koning, N. and Goverse, G. and van der Pol, S.M.A. and van het Hof, B. and Gollasch, M. and Drexhage, J.A.R. and Reijerkerk, A. and Meij, I.C. and Mebius, R. and Willnow, T.E. and Müller, D. and Blasig, I.E. and de Vries, H.E.
Acta Neuropathologica 128 (2): 267-277. August 2014

SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia.
Glerup, S. and Olsen, D. and Vaegter, C.B. and Gustafsen, C. and Sjoegaard, S.S. and Hermey, G. and Kjolby, M. and Molgaard, S. and Ulrichsen, M. and Boggild, S. and Skeldal, S. and Fjorback, A.N. and Nyengaard, J.R. and Jacobsen, J. and Bender, D. and Bjarkam, C.R. and Sørensen, E.S. and Füchtbauer, E.M. and Eichele, G. and Madsen, P. and Willnow, T.E. and Petersen, C.M. and Nykjaer, A.
Neuron 82 (5): 1074-87. 4 June 2014

LRP2 mediates folate uptake in the developing neural tube.
Kur, E. and Mecklenburg, N. and Cabrera, R.M. and Willnow, T.E. and Hammes, A.
Journal of Cell Science 127 (Pt 10): 2261-2268. 15 May 2014

Apolipoprotein E receptor pathways in Alzheimer disease.
Schmidt, V. and Carlo, A.S. and Willnow, T.E.
Wiley Interdisciplinary Reviews Systems Biology and Medicine 6 (3): 255-270. May 2014

Lysosomal sorting of amyloid-β by the SORLA receptor is impaired by a familial Alzheimer's disease mutation.
Caglayan, S. and Takagi-Niidome, S. and Liao, F. and Carlo, A.S. and Schmidt, V. and Burgert, T. and Kitago, Y. and Füchtbauer, E.M. and Füchtbauer, A. and Holtzman, D.M. and Takagi, J. and Willnow, T.E.
Science Translational Medicine 6 (223): 223ra20. 12 February 2014

2013

SORLA-dependent and -independent functions for PACS1 in control of amyloidogenic processes.
Burgert, T. and Schmidt, V. and Caglayan, S. and Lin, F. and Füchtbauer, A. and Füchtbauer, E.M. and Nykjaer, A. and Carlo, A.S. and Willnow, T.E.
Molecular and Cellular Biology 33 (21): 4308-4320. November 2013

Sortilin-related receptor SORCS3 is a postsynaptic modulator of synaptic depression and fear extinction.
Breiderhoff, T. and Christiansen, G.B. and Pallesen, L.T. and Vaegter, C. and Nykjaer, A. and Holm, M.M. and Glerup, S. and Willnow, T.E.
PLoS ONE 8 (9): e75006. 19 September 2013

Sortilin, a novel APOE receptor implicated in Alzheimer disease.
Carlo, A.S.
Prion 7 (5): 378-382. September 2013

SORLA-mediated trafficking of TrkB enhances the response of neurons to BDNF.
Rohe, M. and Hartl, D. and Fjorback, A.N. and Klose, J. and Willnow, T.E.
PLoS ONE 8 (8): e72164. 19 August 2013

Sorting receptor SORLA - a trafficking path to avoid Alzheimer disease.
Willnow, T.E. and Andersen, O.M.
Journal of Cell Science 126 (Pt 13): 2751-2760. 1 July 2013

Cellular and molecular basis of cerebellar development.
Martinez, S. and Andreu, A. and Mecklenburg, N. and Echevarria, D.
Frontiers in Neuroanatomy 7 : 18. 26 June 2013

Soluble alpha-APP (sAPPalpha) regulates CDK5 expression and activity in neurons.
Hartl, D. and Klatt, S. and Roch, M. and Konthur, Z. and Klose, J. and Willnow, T.E. and Rohe, M.
PLoS ONE 8 (6): e65920. 11 June 2013

Production of glycosylated soluble amyloid precursor protein alpha (sAPPalpha) in Leishmania tarentolae.
Klatt, S. and Rohe, M. and Alagesan, K. and Kolarich, D. and Konthur, Z. and Hartl, D.
Journal of Proteome Research 12 (1): 396-403. 4 January 2013

The pro-neurotrophin receptor sortilin is a major neuronal apolipoprotein E receptor for catabolism of amyloid-β peptide in the brain.
Carlo, A.S. and Gustafsen, C. and Mastrobuoni, G. and Nielsen, M.S. and Burgert, T. and Hartl, D. and Rohe, M. and Nykjaer, A. and Herz, J. and Heeren, J. and Kempa, S. and Petersen, C.M. and Willnow, T.E.
Journal of Neuroscience 33 (1): 358-370. 2 January 2013

SorLA deficiency dissects amyloid pathology from tau and cholinergic neurodegeneration in a mouse model of Alzheimer's disease.
Capsoni, S. and Carlo, A.S. and Vignone, D. and Amato, G. and Criscuolo, C. and Willnow, T.E. and Cattaneo, A.
Journal of Alzheimer's Disease 33 (2): 357-371. 2013

2012

Endocytic receptor-mediated control of morphogen signaling.
Willnow, T.E. and Christ, A. and Hammes, A.
Development 139 (23): 4311-4319. 1 December 2012

The sorting receptor sortilin exhibits a dual function in exocytic trafficking of interferon-γ and granzyme A in T cells.
Herda, S. and Raczkowski, F. and Mittruecker, H.W. and Willimsky, G. and Gerlach, K. and Kuehl, A.A. and Breiderhoff, T. and Willnow, T.E. and Doerken, B. and Hoepken, U.E. and Rehm, A.
Immunity 37 (5): 854-866. 16 November 2012

Deletion of claudin-10 (Cldn10) in the thick ascending limb impairs paracellular sodium permeability and leads to hypermagnesemia and nephrocalcinosis.
Breiderhoff, T. and Himmerkus, N. and Stuiver, M. and Mutig, K. and Will, C. and Meij, I.C. and Bachmann, S. and Bleich, M. and Willnow, T.E. and Mueller, D.
Proceedings of the National Academy of Sciences of the United States of America 109 (35): 14241-14246. 28 August 2012

Multi-compartmental modeling of SORLA's influence on amyloidogenic processing in Alzheimer's disease.
Lao, A. and Schmidt, V. and Schmitz, Y. and Willnow, T.E. and Wolkenhauer, O.
BMC Systems Biology 6 (1): 74. 22 June 2012

Presymptomatic alterations in energy metabolism and oxidative stress in the APP23 mouse model of Alzheimer disease.
Hartl, D. and Schuldt, V. and Forler, S. and Zabel, C. and Klose, J. and Rohe, M.
Journal of Proteome Research 11 (6): 3295-3304. 8 May 2012

Sortilin: a receptor to regulate neuronal viability and function.
Nykjaer, A. and Willnow, T.E.
Trends in Neurosciences 35 (4): 261-270. April 2012

Identification of Alzheimer disease risk genotype that predicts efficiency of SORL1 expression in the brain.
Caglayan, S. and Bauerfeind, A. and Schmidt, V. and Carlo, A.S. and Prabakaran, T. and Huebner, N. and Willnow, T.E.
Archives of Neurology 69 (3): 373-379. March 2012

LRP2 is an auxiliary SHH receptor required to condition the forebrain ventral midline for inductive signals.
Christ, A. and Christa, A. and Kur, E. and Lioubinski, O. and Bachmann, S. and Willnow, T.E. and Hammes, A.
Developmental Cell 22 (2): 268-278. 14 February 2012

Retromer binds the FANSHY sorting motif in SorLA to regulate amyloid precursor protein sorting and processing.
Fjorback, A.W. and Seaman, M. and Gustafsen, C. and Mehmedbasic, A. and Gokool, S. and Wu, C. and Militz, D. and Schmidt, V. and Madsen, P. and Nyengaard, J.R. and Willnow, T.E. and Christensen, E.I. and Mobley, W.B. and Nykjaer, A. and Andersen, O.M.
Journal of Neuroscience 32 (4): 1467-1480. 25 January 2012

Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease.
Schmidt, V. and Baum, K. and Lao, A. and Rateitschak, K. and Schmitz, Y. and Teichmann, A. and Wiesner, B. and Petersen, C.M. and Nykjaer, A. and Wolf, J. and Wolkenhauer, O. and Willnow, T.E.
EMBO Journal 31 (1): 187-200. 4 January 2012

2011

Loss of Lrp2 in zebrafish disrupts pronephric tubular clearance but not forebrain development.
Kur, E. and Christa, A. and Veth, K.N. and Gajera, C.R. and Andrade-Navarro, M.A. and Zhang, J. and Willer, J.R. and Gregg, R.G. and Abdelilah-Seyfried, S. and Bachmann, S. and Link, B.A. and Hammes, A. and Willnow, T.E.
Developmental Dynamics 240 (6): 1567-1577. June 2011

Kainate promotes alterations in neuronal RNA splicing machinery.
Rohe, M. and Nebrich, G. and Klein, O. and Mao, L. and Zabel, C. and Klose, J. and Hartl, D.
Journal of Proteome Research 10 (4): 1459-1467. 1 April 2011

Sortilins: new players in lipoprotein metabolism.
Willnow, T.E. and Kjolby, M. and Nykjaer, A.
Current Opinion in Lipidology 22 (2): 79-85. April 2011

CNNM2, encoding a basolateral protein required for renal Mg(2+) handling, is mutated in dominant hypomagnesemia.
Stuiver, M. and Lainez, S. and Will, C. and Terryn, S. and Guenzel, D. and Debaix, H. and Sommer, K. and Kopplin, K. and Thumfart, J. and Kampik, N.B. and Querfeld, U. and Willnow, T.E. and Nemec, V. and Wagner, C.A. and Hoenderop, J.G. and Devuyst, O. and Knoers, N.V. and Bindels, R.J. and Meij, I.C. and Mueller, D.
American Journal of Human Genetics 88 (3): 333-343. 11 March 2011

Impaired aldosterone responsiveness in Corticosteroid Binding Globulin (CBG) deficient mice.
Sorensen, M.V. and Praetorius, H.A. and Nykjaer, A. and Willnow, T.E. and Leipziger, J.
Acta Physiologica 201 (1): 169-177. January 2011

Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling.
Vaegter, C.B. and Jansen, P. and Fjorback, A.W. and Glerup, S. and Skeldal, S. and Kjolby, M. and Richner, M. and Erdmann, B. and Nyengaard, J.R. and Tessarollo, L. and Lewin, G.R. and Willnow, T.E. and Chao, M.V. and Nykjaer, A.
Nature Neuroscience 14 (1): 54-61. January 2011

2010

Cubilin is essential for albumin reabsorption in the renal proximal tubule.
Amsellem, S. and Gburek, J. and Hamard, G. and Nielsen, R. and Willnow, T.E. and Devuyst, O. and Nexo, E. and Verroust, P.J. and Christensen, E.I. and Kozyraki, R.
Journal of the American Society of Nephrology 21 (11): 1859-1867. November 2010

Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export.
Kjolby, M. and Andersen, O.M. and Breiderhoff, T. and Fjorback, A.W. and Pedersen, K.M. and Madsen, P. and Jansen, P. and Heeren, J. and Willnow, T.E. and Nykjaer, A.
Cell Metabolism 12 (3): 213-223. 8 September 2010

The soluble intracellular domain of megalin does not affect renal proximal tubular function in vivo.
Christ, A. and Terryn, S. and Schmidt, V. and Christensen, E.I. and Huska, M.R. and Andrade-Navarro, M.A. and Huebner, N. and Devuyst, O. and Hammes, A. and Willnow, T.E.
Kidney International 78 (5): 473-477. September 2010

LRP2 in ependymal cells regulates BMP signaling in the adult neurogenic niche.
Gajera, C.R. and Emich, H. and Lioubinski, O. and Christ, A. and Beckervordersandforth-Bonk, R. and Yoshikawa, K. and Bachmann, S. and Christensen, E.I. and Goetz, M. and Kempermann, G. and Peterson, A.S. and Willnow, T.E. and Hammes, A.
Journal of Cell Science 123 (Pt 11): 1922-1930. 1 June 2010

SORLA/SORL1 functionally interacts with SPAK to control renal activation of Na+-K+-Cl- cotransporter 2.
Reiche, J. and Theilig, F. and Rafiqi, F.H. and Carlo, A.S. and Militz, D. and Mutig, K. and Todiras, M. and Christensen, E.I. and Ellison, D.H. and Bader, M. and Nykjaer, A. and Bachmann, S. and Alessi, D. and Willnow, T.E.
Molecular and Cellular Biology 30 (12): 3027-3037. June 2010

Targeted deletion of murine Cldn16 identifies extra- and intrarenal compensatory mechanisms of Ca2+ and Mg2+ wasting.
Will, C. and Breiderhoff, T. and Thumfart, J. and Stuiver, M. and Kopplin, K. and Sommer, K. and Guenzel, D. and Querfeld, U. and Meij, I.C. and Shan, Q. and Bleich, M. and Willnow, T.E. and Mueller, D.
American Journal of Physiology Renal Physiology 298 (5): F1152-F1161. May 2010

Identification of a linear epitope in sortilin that partakes in pro-neurotrophin binding.
Andersen, O.S. and Boisguerin, P. and Glerup, S. and Skeldal, S. and Volkmer, R. and Willnow, T.E. and Nykjaer, A. and Andersen, O.M.
Journal of Biological Chemistry 285 (16): 12210-12222. 16 April 2010

Cellular uptake of steroid carrier proteins - mechanisms and implications.
Willnow, T.E. and Nykjaer, A.
Molecular and Cellular Endocrinology 316 (1): 93-102. 5 March 2010

Establishment of a neuroepithelial barrier by Claudin5a is essential for zebrafish brain ventricular lumen expansion.
Zhang, J. and Piontek, J. and Wolburg, H. and Piehl, C. and Liss, M. and Otten, C. and Christ, A. and Willnow, T.E. and Blasig, I.E. and Abdelilah-Seyfried, S.
Proceedings of the National Academy of Sciences of the United States of America 107 (4): 1425-1430. 26 January 2010

SORLA/SORL1, a neuronal sorting receptor implicated in Alzheimer's disease.
Willnow, T.E. and Carlo, A.S. and Rohe, M. and Schmidt, V.
Reviews in the Neurosciences 21 (4): 315-329. 2010

2009

Brain-derived neurotrophic factor reduces amyloidogenic processing through control of SORLA gene expression.
Rohe, M. and Synowitz, M. and Glass, R. and Paul, S.M. and Nykjaer, A. and Willnow, T.E.
Journal of Neuroscience 29 (49): 15472-15478. 9 December 2009

PET imaging of leptin biodistribution and metabolism in rodents and primates.
Ceccarini, G. and Flavell, R.R. and Butelman, E.R. and Synan, M. and Willnow, T.E. and Bar-Dagan, M. and Goldsmith, S.J. and Kreek, M.J. and Kothari, P. and Vallabhajosula, S. and Muir, T.W. and Friedman, J.M.
Cell Metabolism 10 (2): 148-159. 6 August 2009

EUNEFRON, the European Network for the Study of Orphan Nephropathies.
Devuyst, O. and Meij, I. and Jeunemaitre, X. and Ronco, P. and Antignac, C. and Christensen, E.I. and Knoers, N.V. and Levtchenko, E.N. and Deen, P.M. and Mueller, D. and Wagner, C.A. and Rampoldi, L. and van't Hoff, W.G.
Nephrology Dialysis Transplantation 24 (7): 2011-2015. July 2009

Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11.
Spoelgen, R. and Adams, K.W. and Koker, M. and Thomas, A.V. and Andersen, O.M. and Hallett, P.J. and Bercury, K.K. and Joyner, D.F. and Deng, M. and Stoothoff, W.H. and Strickland, D.K. and Willnow, T.E. and Hyman, B.T.
Neuroscience 158 (4): 1460-1468. 18 February 2009

2008

VPS10P-domain receptors - regulators of neuronal viability and function.
Willnow, T.E. and Petersen, C.M. and Nykjaer, A.
Nature Reviews Neuroscience 9 (12): 899-909. December 2008

Loss of LR11/SORLA enhances early pathology in a mouse model of amyloidosis: Evidence for a proximal role in Alzheimer's disease.
Dodson, S.E. and Andersen, O.M. and Karmali, V. and Fritz, J.J. and Cheng, D. and Peng, J. and Levey, A.I. and Willnow, T.E. and Lah, J.J.
Journal of Neuroscience 28 (48): 12877-12886. 26 November 2008

Megalin contributes to the early injury of proximal tubule cells during nonselective proteinuria.
Motoyoshi, Y. and Matsusaka, T. and Saito, A. and Pastan, I. and Willnow, T.E. and Mizutani, S. and Ichikawa, I.
Kidney International 74 (10): 1262-1269. 2 November 2008

Magnesium stimulates renal phosphate reabsorption.
Thumfart, J. and Jung, S. and Amasheh, S. and Kraemer, S. and Peters, H. and Sommer, K. and Biber, J. and Murer, H. and Meij, I.C. and Querfeld, U. and Wagner, C.A. and Mueller, D.
American Journal of Physiology Renal Physiology 295 (4): F1126-1133. 9 October 2008

A novel renal carbonic anhydrase type III plays a role in proximal tubule dysfunction.
Gailly, P. and Jouret, F. and Martin, D. and Debaix, H. and Parreira, K.S. and Nishita, T. and Blanchard, A. and Antignac, C. and Willnow, T.E. and Courtoy, P.J. and Scheinman, S.J. and Christensen, E.I. and Devuyst, O.
Kidney International 74 (1): 52-61. 1 July 2008

Sortilin-related receptor with A-type repeats (SORLA) affects the amyloid precursor protein-dependent stimulation of ERK signaling and adult neurogenesis.
Rohe, M. and Carlo, A.S. and Breyhan, H. and Sporbert, A. and Militz, D. and Schmidt, V. and Wozny, C. and Harmeier, A. and Erdmann, B. and Bales, K.R. and Wolf, S.A. and Kempermann, G. and Paul, S.M. and Schmitz, D. and Bayer, T.A. and Willnow, T.E. and Andersen, O.M.
Journal of Biological Chemistry 283 (21): 14826-14834. 23 May 2008

Endocytosis of sex steroids: The hypothesis of free hormones revisited.
Willnow, T.E. and Hammes, A. and Nykjaer, A.
Annales d'Endocrinologie 69 (2): 101-102. April 2008

2007

Localization of the low-density lipoprotein receptor-related protein regions involved in binding to the A2 domain of coagulation factor VIII.
Sarafanov, A.G. and Makogonenko, E.M. and Andersen, O.M. and Mikhailenko, I.A. and Ananyeva, N.M. and Khrenov, A.V. and Shima, M. and Strickland, D.K. and Saenko, E.L.
Thrombosis and Haemostasis 98 (6): 1170-1181. December 2007

SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1.
Schmidt, V. and Sporbert, A. and Rohe, M. and Reimer, T. and Rehm, A. and Andersen, O.M. and Willnow, T.E.
Journal of Biological Chemistry 282 (45): 32956-32964. 9 November 2007

Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury.
Jansen, P. and Giehl, K. and Nyengaard, J.R. and Teng, K. and Lioubinski, O. and Sjoegaard, S.S. and Breiderhoff, T. and Gotthardt, M. and Lin, F. and Eilers, A. and Petersen, C.M. and Lewin, G.R. and Hempstead, B.L. and Willnow, T.E. and Nykjaer, A.
Nature Neuroscience 10 (11): 1449-1457. November 2007

Lipoproteins and their receptors in embryonic development: more than cholesterol clearance.
Willnow, T.E. and Hammes, A. and Eaton, S.
Development 134 (18): 3239-3249. September 2007

L1 retrotransposition can occur early in human embryonic development.
van den Hurk, J.A. and Meij, I.C. and Seleme, M.C. and Kano, H. and Nikopoulos, K. and Hoefsloot, L.H. and Sistermans, E.A. and de Wijs, I.J. and Mukhopadhyay, A. and Plomp, A.S. and de Jong, P.T. and Kazazian, H.H. and Cremers, F.P.
Human Molecular Genetics 16 (13): 1587-1592. 1 July 2007

Abrogation of Protein Uptake through Megalin-Deficient Proximal Tubules Does Not Safeguard against Tubulointerstitial Injury.
Theilig, F. and Kriz, W. and Jerichow, T. and Schrade, P. and Hahnel, B. and Willnow, T.E. and Le Hir, M. and Bachmann, S.
Journal of the American Society of Nephrology 18 (6): 1824-1834. June 2007

Endocytosis provides a major alternative pathway for lysosomal biogenesis in kidney proximal tubular cells.
Nielsen, R. and Courtoy, P.J. and Jacobsen, C. and Dom, G. and Lima, W.R. and Jadot, M. and Willnow, T.E. and Devuyst, O. and Christensen, E.I.
Proceedings of the National Academy of Sciences of the United States of America 104 (13): 5407-5412. 27 March 2007

The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease.
Rogaeva, E. and Meng, Y. and Lee, J.H. and Gu, Y. and Kawarai, T. and Zou, F. and Katayama, T. and Baldwin, C.T. and Cheng, R. and Hasegawa, H. and Chen, F. and Shibata, N. and Lunetta, K.L. and Pardossi-Piquard, R. and Bohm, C. and Wakutani, Y. and Cupples, L.A. and Cuenco, K.T. and Green, R.C. and Pinessi, L. and Rainero, I. and Sorbi, S. and Bruni, A. and Duara, R. and Friedland, R.P. and Inzelberg, R. and Hampe, W. and Bujo, H. and Song, Y.Q. and Andersen, O.M. and Willnow, T.E. and Graff-Radford, N. and Petersen, R.C. and Dickson, D. and Der, S.D. and Fraser, P.E. and Schmitt-Ulms, G. and Younkin, S. and Mayeux, R. and Farrer, L.A. and St George-Hyslop, P.
Nature Genetics 39 (2): 168-177. February 2007

2006

Lipoprotein receptors in Alzheimer's disease.
Andersen, O.M. and Willnow, T.E.
Trends in Neurosciences 29 (12): 687-694. December 2006

The solution structure of the core of mesoderm development (MESD), a chaperone for members of the LDLR-family.
Koehler, C. and Andersen, O.M. and Diehl, A. and Krause, G. and Schmieder, P. and Oschkinat, H.
Journal of Structural and Functional Genomics 7 (3-4): 131-138. December 2006

Hyporesponsiveness to glucocorticoids in mice genetically deficient for the corticosteroid binding globulin.
Petersen, H.H. and Andreassen, T.K. and Breiderhoff, T. and Braesen, J.H. and Schulz, H. and Gross, V. and Groene, H.J. and Nykjaer, A. and Willnow, T.E.
Molecular and Cellular Biology 26 (19): 7236-7245. October 2006

Binding site structure of one LRP/RAP complex - implications for a common ligand/receptor binding motif.
Jensen, G.A. and Andersen, O.M. and Bonvin, A.M.J.J. and Bjerrum-Bohr, I. and Etzerodt, M. and Thogersen, H.C. and O'Shea, C. and Poulsen, F.M. and Kragelund, B.B.
Journal of Molecular Biology 362 (4): 700-716. 29 September 2006

Unusual clinical presentation and possible rescue of a novel Claudin-16 mutation.
Mueller, D. and Kausalya, P.J. and Bockenhauer, D. and Tumfart, J. and Meij, I.C. and Dillon, M.J. and van't Hoff, W. and Hunziker, W.
Journal of Clinical Endocrinology and Metabolism 91 (8): 3076-3079. August 2006

Pin-pointing APP processing.
Willnow, T.E. and Andersen, O.M.
Molecular Interventions 6 (3): 137-139. June 2006

Elucidation of megalin/LRP2-dependent endocytic transport processes in the larval zebrafish pronephros.
Anzenberger, U. and Bit-Avragim, N. and Rohr, S. and Rudolph, F. and Dehmel, B. and Willnow, T.E. and Abdelilah-Seyfried, S.
Journal of Cell Science 119 (Pt. 10): 2127-2137. 15 May 2006

Familial hypomagnesemia with hypercalciuria and nephrocalcinosis: blocking endocytosis restores surface expression of a novel Claudin-16 mutant that lacks the entire C-terminal cytosolic tail.
Mueller, D. and Kausalya, P.J. and Meij, I.C. and Hunziker, W.
Human Molecular Genetics 15 (7): 1049-1058. 1 April 2006

Apoptosis repressor with caspase recruitment domain is required for cardioprotection in response to biomechanical and ischemic stress.
Donath, S. and Li, P. and Willenbockel, C. and Al-Saadi, N. and Gross, V. and Willnow, T.E. and Bader, M. and Martin, U. and Bauersachs, J. and Wollert, K.C. and Dietz, R. and von Harsdorf, R.
Circulation 113 (9): 1203-1212. 7 March 2006

Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11.
Andersen, O.M. and Schmidt, V. and Spoelgen, R. and Gliemann, J. and Behlke, J. and Galatis, D. and McKinstry, W.J. and Parker, M.W. and Masters, C.L. and Hyman, B.T. and Cappai, R. and Willnow, T.E.
Biochemistry 45 (8): 2618-2628. 28 February 2006

Response: Cellular uptake of sex steroid hormones.
Willnow, T.E. and Nykjaer, A.
Cell 124 (3): 456-457. 10 February 2006

Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme.
Spoelgen, R. and von Arnim, C.A. and Thomas, A.V. and Peltan, I.D. and Koker, M. and Deng, A. and Irizarry, M.C. and Andersen, O.M. and Willnow, T.E. and Hyman, B.T.
Journal of Neuroscience 26 (2): 418-428. 11 January 2006

2005

Megalin-mediated reuptake of retinol in the kidneys of mice is essential for vitamin a homeostasis.
Raila, J. and Willnow, T.E. and Schweigert, F.J.
Journal of Nutrition 135 (11): 2512-2516. 1 November 2005

Megalin is essential for renal proximal tubule reabsorption of 111In-DTPA-octreotide.
de Jong, M. and Barone, R. and Krenning, E. and Bernard, B. and Melis, M. and Visser, T. and Gekle, M. and Willnow, T.E. and Walrand, S. and Jamar, F. and Pauwels, S.
Journal of Nuclear Medicine 46 : 1696-1700. 1 October 2005

Role of endocytosis in cellular uptake of sex steroids.
Hammes, A. and Andreassen, T.K. and Spoelgen, R. and Raila, J. and Huebner, N. and Schulz, H. and Metzger, J. and Schweigert, F.J. and Luppa, P.B. and Nykjaer, A. and Willnow, T.E.
Cell 122 (5): 751-762. 9 September 2005

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.
Andersen, O.M. and Reiche, J. and Schmidt, V. and Gotthardt, M. and Spoelgen, R. and Behlke, J. and von Arnim, C.A.F. and Breiderhoff, T. and Jansen, P. and Wu, X. and Bales, K.R. and Cappai, R. and Masters, C.L. and Gliemann, J. and Mufson, E.J. and Hyman, B.T. and Paul, S.M. and Nykjaer, A. and Willnow, T.E.
Proceedings of the National Academy of Sciences of the United States of America 102 (38): 13461-13466. 7 September 2005

The European Renal Genome Project: An integrated approach towards understanding the genetics of kidney development and disease.
Willnow, T.E. and Antignac, C. and Braendli, A.W. and Christensen, E.I. and Cox, R.D. and Davidson, D. and Davies, J.A. and Devuyst, O. and Eichele, G. and Hastie, N.D. and Verroust, P.J. and Schedl, A. and Meij, I.C.
Organogenesis 2 (2): 42-47. April 2005

A splice variant of the Wilms' tumour suppressor Wt1 is required for normal development of the olfactory system.
Wagner, N. and Wagner, K.D. and Hammes, A. and Kirschner, K.M. and Vidal, V.R. and Schedl, A. and Scholz, H.
Development 132 (6): 1327-1336. 1 January 2005

Endocytic pathways for 25-(OH) vitamin D3.
Willnow, T.E. and Nykjaer, A.
In: Vitamin D ; vol 1. Elsevier, Amsterdam [u.a.], 153-163. ISBN 0-12-252689-9 1 January 2005

LRP2/megalin is required for patterning of the ventral telencephalon.
Spoelgen, R. and Hammes, A. and Anzenberger, U. and Zechner, D. and Andersen, O.M. and Jerchow, B. and Willnow, T.E.
Development 132 (2): 405-414. 1 January 2005

Mutually-dependent localization of megalin and Dab2 in the renal proximal tubule.
Nagai, J. and Christensen, E.I. and Morris, S.M. and Willnow, T.E. and Cooper, J.A. and Nielsen, R.
American Journal of Physiology Renal Physiology 289 (3): F569-F576. 1 January 2005

p75NTR - live or let die.
Nykjaer, A. and Willnow, T.E. and Petersen, C.M.
Current Opinion in Neurobiology 15 (1): 49-57. 1 January 2005

2004

α-tropomyosin mutations Asp175Asn and Glu180Gly affect cardiac function in transgenic rats in different ways.
Wernicke, D. and Thiel, C. and Duja-Isac, C.M. and Essine, K.V. and Spindler, M. and Nunez, D.J.R. and Plehm, R. and Wessel, N. and Hammes, A. and Edwards, R.J. and Lippoldt, A. and Zacharias, U. and Stroemer, H. and Neubauer, S. and Davies, M.J. and Morano, I. and Thierfelder, L.
American Journal of Physiology Regulatory Integrative and Comparative Physiology 287 (3): R685-R695. 1 September 2004

Kidney-specific inactivation of the megalin gene impairs trafficking of renal inorganic sodium phosphate cotransporter (NaPi-IIa).
Bachmann, S. and Schlichting, U. and Geist, B. and Mutig, K. and Petsch, T. and Bacic, D. and Wagner, C.A. and Kaissling, B. and Biber, J. and Murer, H. and Willnow, T.E.
Journal of the American Society of Nephrology 15 (4): 892-900. 1 April 2004

Sortilin is essential for proNGF-induced neuronal cell death.
Nykjaer, A. and Lee, R. and Teng, K.K. and Jansen, P. and Madsen, P. and Nielsen, M.S. and Jacobsen, C. and Kliemannel, M. and Schwarz, E. and Willnow, T.E. and Hempstead, B.L. and Petersen, C.M.
Nature 427 (6977): 843-848. 26 February 2004

Effect of Add1 gene transfer on blood pressure in reciprocal congenic strains of Milan rats.
Tripodi, G. and Florio, M. and Ferrandi, M. and Modica, R. and Zimdahl, H. and Huebner, N. and Ferrari, P. and Bianchi, G.
Biochemical and Biophysical Research Communications 324 (2): 562-568. 1 January 2004

Low-density lipoprotein receptor-related protein interacts with MafB, a regulator of hindbrain development.
Petersen, H.H. and Hilpert, J. and Jacobsen, C. and Lauwers, A. and Roebroek, A.J.M. and Willnow, T.E.
FEBS Letters 565 (1-3): 23-27. 1 January 2004

Applications of interspersed repeat sequence polymerase chain reaction.
Zimdahl, H. and Goesele, C. and Kreitler, T. and Knoblauch, M.
Methods in Molecular Biology 255 : 113-129. 2004

2003

Agents for the prevention of organ damage induced by therapeutic agents.
Willnow, T.E.
US2003202974. 30 October 2003

Renal uptake of myoglobin is mediated by the endocytic receptors megalin and cubilin.
Gburek, J. and Birn, H. and Verroust, P.J. and Goj, B. and Jacobsen, C. and Moestrup, S.K. and Willnow, T.E. and Christensen, E.I.
American Journal of Physiology Renal Physiology 285 (3): F451-F458. 1 September 2003

Differential binding of ligands to the apolipoprotein E receptor 2.
Andersen, O.M. and Benhayon, D. and Curran, T. and Willnow, T.E.
Biochemistry 42 (31): 9355-9364. 12 August 2003

Essential role of the apolipoprotein E receptor-2 in sperm development.
Andersen, O.M. and Yeung, C.H. and Vorum, H. and Wellner, M. and Andreassen, T.K. and Erdmann, B. and Mueller, E.C. and Herz, J. and Otto, A. and Cooper, T.G. and Willnow, T.E.
Journal of Biological Chemistry 278 (26): 23989-23995. 27 June 2003

Hypocalcemia and osteopathy in mice with kidney-specific megalin gene defect.
Leheste, J.R. and Melsen, F. and Wellner, M. and Jansen, P. and Schlichting, U. and Renner-Mueller, I. and Andreassen, T.T. and Wolf, E. and Bachmann, S. and Nykjaer, A. and Willnow, T.E.
FASEB Journal 17 (2): 247-249. February 2003

Functional interaction of megalin with the megalin-binding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule.
Heibroch Petersen, H. and Hilpert, J. and Militz, D. and Zandler, V. and Jacobsen, C. and Roebroek, A.J.M. and Willnow, T.E.
Journal of Cell Science 116 : 453-461. 1 January 2003

Preferential megalin-mediated transcytosis of low-hormonogenic thyroglobulin: A control mechanism for thyroid hormone release.
Lisi, S. and Pinchera, A. and McCluskey, R.T. and Willnow, T.E. and Refetoff, S. and Marcocci, C. and Vitti, P. and Menconi, F. and Grasso, L. and Luchetti, F. and Collins, A.B. and Marino, M.
Proceedings of the National Academy of Sciences of the United States of America 100 (25): 14858-14863. 1 January 2003

From holoprosencephaly to osteopathology: role of multifunctional endocytic receptors in absorptive epithelia.
Mueller, D. and Nykjaer, A. and Willnow, T.E.
Annals of Medicine 35 (5): 290-299. 2003

2002

Expression profiling confirms the role of endocytic receptor megalin in renal vitamin D-3 metabolism.
Hilpert, J. and Wogensen, L. and Thykjaer, T. and Wellner, M. and Schlichting, U. and Orntoft, T.F. and Bachmann, S. and Nykjaer, A. and Willnow, T.E.
Kidney International 62 (5): 1672-1681. November 2002

Increased expression of renal neutral endopeptidase in severe heart failure.
Knecht, M. and Pagel, I. and Langenickel, T. and Philipp, S. and Scheuermann-Freestone, M. and Willnow, T.E. and Bruemmer, D. and Graf, K. and Dietz, R. and Willenbrock, R.
Life Sciences 71 (23): 2701-2712. 25 October 2002

The low-density lipoprotein receptor gene family: a cellular Swiss army knife?
Nykjaer, A. and Willnow, T.E.
Trends in Cell Biology 12 (6): 273-280. 1 June 2002

Pathways for kidney-specific uptake of the steroid hormone 25-hydroxyvitamin D(3).
Willnow, T.E. and Nykjaer, A.
Current Opinion in Lipidology 13 (3): 255-260. June 2002

Mittel zur Praevention von Organschaeden, die durch Aminoglykoside induziert werden.
Willnow, T.E.
DE10053506A1. 2 May 2002

Early gonadal development: exploring Wt1 and Sox9 function.
Guo, J.K. and Hammes, A. and Chaboissier, M.C. and Vidal, V. and Xing, Y. and Wong, F. and Schedl, A.
Novartis Foundation Symposium 244 : 23-31. 1 March 2002

Megalin and cubilin are Endocytic receptors involved in renal clearance of hemoglobin.
Gburek, J. and Verroust, P.J. and Willnow, T.E. and Fyfe, J.C. and Nowacki, W. and Jacobsen, C. and Moestrup, S.K. and Christensen, E.I.
Journal of the American Society of Nephrology 13 : 423-430. 1 January 2002

Megalin deficiency offers protection from renal aminoglycoside accumulation.
Schmitz, C. and Hilpert, J. and Jacobsen, C. and Boensch, C. and Christensen, E.I. and Luft, F.C. and Willnow, T.E.
Journal of Biological Chemistry 277 : 618-622. 1 January 2002

Megalin is essential for renal proximal tubule reabsorption and accumulation of transcobalamin-B-12.
Birn, H. and Willnow, T.E. and Nielsen, R. and Norden, A.G.W. and Boensch, C. and Moestrup, S.K. and Nexo, E. and Christensen, E.I.
American Journal of Physiology Renal Physiology 282 (3): F408-F416. 1 January 2002

2001

A two-receptor pathway for catabolism of Clara cell secretory protein in the kidney.
Burmeister, R. and Boe, I.M. and Nykjaer, A. and Jacobsen, C. and Moestrup, S.K. and Verroust, P. and Christensen, E.I. and Lund, J. and Willnow, T.E.
Journal of Biological Chemistry 276 (16): 13295-13301. 1 January 2001

Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D-3.
Nykjaer, A. and Fyfe, J.C. and Kozyraki, R. and Leheste, J.R. and Jacobsen, C. and Nielsen, M.S. and Verroust, P.J. and Aminoff, M. and de la Chapelle, A. and Moestrup, S.K. and Ray, R. and Gliemann, J. and Willnow, T.E. and Christensen, E.I.
Proceedings of the National Academy of Sciences of the United States of America 98 (24): 13895-13900. 1 January 2001

Efficient eukaryotic expression system for authentic human sex hormone-binding globulin.
Hilpert, J. and Vorum, H. and Burmeister, R. and Spoelgen, R. and Grishkovskaya, I. and Misselwitz, R. and Nykjaer, A. and Willnow, T.E.
Biochemical Journal 360 (3): 609-615. 1 January 2001

Holoprosencephaly and low molecular weight proteinuria: the human homologue of murine megalin deficiency.
Mueller, D. and Ankermann, T. and Stephani, U. and Kirschstein, M. and Szelestei, T. and Luft, F.C. and Willnow, T.E.
American Journal of Kidney Diseases 37 (3): 624-628. 1 January 2001

Megalin-dependent cubilin-mediated endocytosis is a major pathway for the apical uptake of transferrin in polarized epithelia.
Kozyraki, R. and Fyfe, J. and Verroust, P.J. and Jacobsen, C. and Dautry-Varsat, A. and Gburek, J. and Willnow, T.E. and Christensen, E.I. and Moestrup, S.K.
Proceedings of the National Academy of Sciences of the United States of America 98 (22): 12491-12496. 1 January 2001

2000

Evidence for the role of megalin in renal uptake of transthyretin.
Sousa, M.M. and Norden, A.G.W. and Jacobsen, C. and Willnow, T.E. and Christensen, E.I. and Thakker, R.V. and Verroust, P.J. and Moestrup, S.K. and Saraiva, M.J.
Journal of Biological Chemistry 275 (49): 38176-38181. 8 December 2000

Normal blood pressure and plasma renin activity in mice lacking the renin-binding protein, a cellular renin inhibitor.
Schmitz, C. and Gotthardt, M. and Hinderlich, S. and Leheste, J.R. and Gross, V. and Vorum, H. and Christensen, E.I. and Luft, F.C. and Takahashi, S. and Willnow, T.E.
Journal of Biological Chemistry 275 (20): 15357-15362. 19 May 2000

Cubilin is an albumin binding protein important for renal tubular albumin reabsorption.
Birn, H. and Fyfe, J.C. and Jacobsen, C. and Mounier, F. and Verroust, P.J. and Orskov, H. and Willnow, T.E. and Moestrup, S.K. and Christensen, E.I.
Journal of Clinical Investigation 105 (10): 1353-1361. May 2000

Cellular signalling by lipoprotein receptors.
Herz, J. and Gotthardt, M. and Willnow, T.E.
Current Opinion in Lipidology 11 (2): 161-166. 1 April 2000

1999

Essential role of megalin in renal proximal tubule for vitamin homeostasis.
Christensen, E.I. and Willnow, T.E.
Journal of the American Society of Nephrology 10 : 2224-2236. 1 October 1999

Lipoprotein receptors: new roles for ancient proteins.
Willnow, T.E. and Nykjaer, A. and Herz, J.
Nature Cell Biology 1 : E157-E162. 1 October 1999

Megalin knockout mice as an animal model of low molecular weight proteinuria.
Leheste, J.R. and Rolinski, B. and Vorum, H. and Hilpert, J. and Nykjaer, A. and Jacobsen, C. and Aucouturier, P. and Moskaug, J.O. and Otto, A. and Christensen, E.I. and Willnow, T.E.
American Journal of Pathology 155 (4): 1361-1370. 1 October 1999

Evidence for an essential role of megalin in transepithelial transport of retinol.
Christensen, E.I. and Moskaug, J.O. and Vorum, H. and Jacobsen, C. and Gundersen, T.E. and Nykjaer, A. and Blomhoff, R. and Willnow, T.E. and Moestrup, S.K.
Journal of the American Society of Nephrology 10 : 685-695. 1 April 1999

Identification of megalin/gp330 as a receptor for lipoprotein(a) in vitro.
Niemeier, A. and Willnow, T.E. and Dieplinger, H. and Jacobsen, C. and Meyer, N. and Hilpert, J. and Beisiegel, U.
Arteriosclerosis Thrombosis and Vascular Biology 19 (3): 552-561. March 1999

The low-density lipoprotein receptor gene family: multiple roles in lipid metabolism.
Willnow, T.E.
Journal of Molecular Medicine 77 (3): 306-315. March 1999

Megalin antagonizes activation of the parathyroid hormone receptor.
Hilpert, J. and Nykjaer, A. and Jacobsen, C. and Wallukat, G. and Nielsen, R. and Moestrup, S.K. and Haller, H. and Luft, F.C. and Christensen, E.I. and Willnow, T.E.
Journal of Biological Chemistry 274 (9): 5620-5625. 26 February 1999

An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D-3.
Nykjaer, A. and Dragun, D. and Walther, D. and Vorum, H. and Jacobsen, C. and Herz, J. and Melsen, F. and Christensen, E.I. and Willnow, T.E.
Cell 96 (4): 507-515. 19 February 1999

1998

beta(2)-glycoprotein-1 (apolipoprotein H) and beta(2)-glycoprotein-1-phospholipid complex harbor a recognition site for the endocytic receptor megalin.
Moestrup, S.K. and Schousboe, I. and Jacobsen, C. and Leheste, J.R. and Christensen, E.I. and Willnow, T.E.
Journal of Clinical Investigation 102 (5): 902-909. 1 September 1998

Receptor-associated protein (RAP): A specialized chaperone for endocytic receptors.
Willnow, T.E.
Biological Chemistry 379 (8-9): 1025-1031. August 1998

1997

Cholesterol, hedgehog and embryogenesis.
Herz, J. and Willnow, T.E. and Farese, R.V.
Nature Genetics 15 (2): 123-124. February 1997

Mechanisms of hepatic chylomicron remnant clearance.
Willnow, T.E.
Diabetic Medicine 14 : S75-S80. 1 January 1997

1996

Sustained somatic gene inactivation by viral transfer of Cre recombinase.
Rohlmann, A. and Gotthardt, M. and Willnow, T.E. and Hammer, R.E. and Herz, J.
Nature Biotechnology 14 (11): 1562-1565. 1 November 1996

Remnant lipoproteins inhibit malaria sporozoite invasion of hepatocytes.
Sinnis, P. and Willnow, T.E. and Briones, M.R. and Herz, J. and Nussenzweig, V.
Journal of Experimental Medicine 184 (3): 945-954. 1 September 1996

The major subunit of the asialoglycoprotein receptor is expressed on the hepatocellular surface in mice lacking the minor receptor subunit.
Braun, J.R. and Willnow, T.E. and Ishibashi, S. and Ashwell, G. and Herz, J.
Journal of Biological Chemistry 271 (35): 21160-21166. 30 August 1996

Defective forebrain development in mice lacking gp330/megalin.
Willnow, T.E. and Hilpert, J. and Armstrong, S.A. and Rohlmann, A. and Hammer, R.E. and Burns, D.K. and Herz, J.
Proceedings of the National Academy of Sciences of the United States of America 93 (16): 8460-8464. 6 August 1996

Heparan sulfate-dependent and low density lipoprotein receptor-related protein-dependent catabolic pathways for lipoprotein lipase in mouse embryonic fibroblasts.
Sehayek, E. and Wang, X.X. and Vlodavsky, I. and Avner, R. and Levkovitz, H. and Olivecrona, T. and Olivecrona, G. and Willnow, T.E. and Herz, J. and Eisenberg, S.
Israel Journal of Medical Sciences 32 (6): 449-454. June 1996

RAP, a specialized chaperone, prevents ligand-induced er retention and degradation of LDL receptor-related endocytic receptors.
Willnow, T.E. and Rohlmann, A. and Horton, J. and Otani, H. and Braun, J.R. and Hammer, R.E. and Herz, J.
EMBO Journal 15 (11): 2632-2639. 1 January 1996

The low-density-lipoprotein receptor-related protein (LRP) is processed by furin in vivo and in vitro.
Willnow, T.E. and Moehring, J.M. and Inocencio, N.M. and Moehring, T.J. and Herz, J.
Biochemical Journal 313 (Pt 1): 71-76. 1 January 1996

1995

Functional expression of low density lipoprotein receptor- related protein is controlled by receptor-associated protein in vivo.
Willnow, T.E. and Armstrong, S.A. and Hammer, R.E. and Herz, J.
Proceedings of the National Academy of Sciences of the United States of America 92 (10): 4537-4541. 9 May 1995

Animal models for disorders of hepatic lipoprotein metabolism.
Willnow, T.E. and Herz, J.
Journal of Molecular Medicine 73 (5): 213-220. May 1995

Lipoprotein and receptor interactions in vivo.
Herz, J. and Willnow, T.E.
Current Opinion in Lipidology 6 (2): 97-103. April 1995

Differential recognition of alpha1-antitrypsin-elastase and alpha1-antichymotrypsin-cathepsin G complexes by the low density lipoprotein receptor-related protein.
Poller, W. and Willnow, T.E. and Hilpert, J. and Herz, J.
Journal of Biological Chemistry 270 (6): 2841-2845. 10 February 1995

1994

Functions of the LDL receptor gene family.
Herz, J. and Willnow, T.E.
Annals of the New York Academy of Sciences 737 : 14-19. 10 September 1994

Low density lipoprotein receptor-related protein is necessary for the internalization of both tissue-type plasminogen activator- inhibitor complexes and free tissue-type plasminogen activator.
Orth, K. and Willnow, T.E. and Herz, J. and Gething, M.J. and Sambrook, J.
Journal of Biological Chemistry 269 (33): 21117-21122. 19 August 1994

Inhibition of hepatic chylomicron remnant uptake by gene transfer of a receptor antagonist.
Willnow, T.E. and Sheng, Z. and Ishibashi, S. and Herz, J.
Science 264 (5164): 1471-1474. 3 June 1994

Molecular dissection of ligand binding sites on the low density lipoprotein receptor-related protein.
Willnow, T.E. and Orth, K. and Herz, J.
Journal of Biological Chemistry 269 (22): 15827-15832. 3 June 1994

Genetic deficiency in low density lipoprotein receptor-related protein confers cellular resistance to Pseudomonas exotoxin A. Evidence that this protein is required for uptake and degradation of multiple ligands.
Willnow, T.E. and Herz, J.
Journal of Cell Science 107 (Pt 3): 719-726. March 1994

Homologous recombination for gene replacement in mouse cell lines.
Willnow, T.E. and Herz, J.
Methods in Cell Biology 43 (Pt A): 305-334. 1994

1992

Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance.
Willnow, T.E. and Goldstein, J.L. and Orth, K. and Brown, M.S. and Herz, J.
Journal of Biological Chemistry 267 (36): 26172-26180. 25 December 1992

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