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Animal models for disorders of hepatic lipoprotein metabolism

Item Type:Review
Title:Animal models for disorders of hepatic lipoprotein metabolism
Creators Name:Willnow, T.E. and Herz, J.
Abstract:The application of methods to create transgenic mice in which a gene of interest is either overexpressed or genetically inactivated has provided us with an ever-growing number of animal models to study complex physiological processes in vivo. Analysis of these mouse models has increased our knowledge about basic mechanisms that control biological systems and the pathological processes in human genetic disorders. This review focuses on the analysis of mouse models in which individual components of the hepatic clearance pathway for plasma lipoproteins have been inactivated. These studies have demonstrated that two hepatic lipoprotein receptors, the low-density lipoprotein receptor and the low-density lipoprotein receptor-related protein operate jointly in the uptake of dietary lipoproteins from the circulation. These findings have important implications for our understanding of pathophysiological processes resulting in hyperlipoproteinemia and atherosclerosis in patients.
Keywords:Low-density lipoprotein receptor, Low-density lipoprotein receptor-related protein, Chylomicron remnants, Hyperlipoproteinemia, Atherosclerosis, Animals, Mice
Source:Journal of Molecular Medicine
Page Range:213-220
Date:May 1995
Official Publication:https://doi.org/10.1007/BF00189920
PubMed:View item in PubMed

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