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SorLA restricts TNFα release from microglia to shape a glioma-supportive brain microenvironment.
Kaminska, P., Ovesen, P.L., Jakiel, M., Obrebski, T., Schmidt, V., Draminski, M., Bilska, A.G., Bieniek, M., Anink, J., Paterczyk, B., Jensen, A.M.G., Piatek, S., Andersen, O.M., Aronica, E., Willnow, T.E., Kaminska, B., Dabrowski, M.J. and Malik, A.R.
EMBO Reports 25 (5): 2278-2305. May 2024

Elevated sortilin expression discriminates functional from non-functional neuroendocrine tumors and enables therapeutic targeting.
Bolduan, F., Wetzel, A., Giesecke, Y., Eichhorn, I., Alenina, N., Bader, M., Willnow, T.E., Wiedenmann, B. and Sigal, M.
Frontiers in Endocrinology 15 : 1331231. 17 April 2024

Amyloid-β aggregates activate peripheral monocytes in mild cognitive impairment.
Juul-Madsen, K., Parbo, P., Ismail, R., Ovesen, P.L., Schmidt, V., Madsen, L.S., Thyrsted, J., Gierl, S., Breum, M., Larsen, A., Andersen, M.N., Romero-Ramos, M., Holm, C.K., Andersen, G.R., Zhao, H., Schuck, P., Nygaard, J.V., Sutherland, D.S., Eskildsen, S.F., Willnow, T.E., Brooks, D.J. and Vorup-Jensen, T.
Nature Communications 15 (1): 1224. 9 February 2024

SORCS2 activity in pancreatic α-cells safeguards insulin granule formation and release from glucose-stressed β-cells.
Kalnytska, O., Qvist, P., Kunz, S., Conrad, T., Willnow, T.E. and Schmidt, V.
iScience 27 (1): 108725. 19 January 2024

Spatially and temporally distinct patterns of expression for VPS10P domain receptors in human cerebral organoids.
Febbraro, F., Andersen, H.H.B., Kitt, M.M. and Willnow, T.E.
Frontiers in Cell and Developmental Biology 11 : 2023. 29 September 2023

Potentiating tweezer affinity to a protein interface with sequence-defined macromolecules on nanoparticles.
Seiler, T., Lennartz, A., Klein, K., Hommel, K., Figueroa Bietti, A., Hadrovic, I., Kollenda, S., Sager, J., Beuck, C., Chlosta, E., Bayer, P., Juul-Madsen, K., Vorup-Jensen, T., Schrader, T., Epple, M., Knauer, S.K. and Hartmann, L.
Biomacromolecules 24 (8): 3666-3679. 14 August 2023

LRP2 contributes to planar cell polarity-dependent coordination of motile cilia function.
Bunatyan, L., Margineanu, A., Boutin, C., Montcouquiol, M., Bachmann, S., Christensen, E.I., Willnow, T.E. and Christ, A.
Cell and Tissue Research 392 (2): 535-551. May 2023

Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames.
Sandmann, C.L., Schulz, J.F., Ruiz-Orera, J., Kirchner, M., Ziehm, M., Adami, E., Marczenke, M., Christ, A., Liebe, N., Greiner, J., Schoenenberger, A., Mücke, M.B., Liang, N., Moritz, R.L., Sun, Z., Deutsch, E.W., Gotthardt, M., Mudge, J.M., Prensner, J.R., Willnow, T.E., Mertins, P., van Heesch, S. and Hubner, N.
Molecular Cell 83 (6): 994-1011.e18. 16 March 2023

Regulation of prostate androgens by megalin and 25-hydroxyvitamin D status: mechanism for high prostate androgens in African American men.
Garcia, J., Krieger, K.D., Loitz, C., Perez, L.M., Richards, Z.A., Helou, Y., Kregel, S., Celada, S., Mesaros, C.A., Bosland, M., Gann, P.H., Willnow, T.E., Vander Griend, D., Kittles, R., Prins, G.S., Penning, T. and Nonn, L.
Cancer Research Communications 3 (3): 371–382. 3 March 2023

Galectin-3 interacts with PD-1 and counteracts the PD-1 pathway-driven regulation of T cell and osteoclast activity in Rheumatoid Arthritis.
Pedersen, K., Nielsen, M.A., Juul-Madsen, K., Hvid, M., Deleuran, B. and Greisen, S.R.
Scandinavian Journal of Immunology 97 (2): e13245. February 2023

SORLA mediates endocytic uptake of proIAPP and protects against islet amyloid deposition.
Shih, A.Z.L., Chen, Y.C., Speckmann, T., Søndergaard, E., Schürmann, A., Verchere, C.B. and Willnow, T.E.
Molecular Metabolism 65 : 101585. November 2022

Targeting SHP2 phosphatase in breast cancer overcomes RTK-mediated resistance to PI3K inhibitors.
Heynen, G.J.J.E., Lisek, K., Vogel, R., Wulf-Goldenberg, A., Alcaniz, J., Montaudon, E., Marangoni, E. and Birchmeier, W.
Breast Cancer Research 24 (1): 23. 1 April 2022

SORLA is required for insulin-induced expansion of the adipocyte precursor pool in visceral fat.
Schmidt, V., Horváth, C., Dong, H., Blüher, M., Qvist, P., Wolfrum, C. and Willnow, T.E.
Journal of Cell Biology 220 (12): e202006058. 6 December 2021

GAS1 is required for Notch-dependent facilitation of SHH signaling in the ventral forebrain neuroepithelium.
Marczenke, M., Sunaga, D., Popp, O., Althaus, I.W., Sauer, S., Mertins, P., Christ, A., Allen, B.L. and Willnow, T.E.
Development 148 (21): dev200080. 11 November 2021

ApoE4 disrupts interaction of sortilin with fatty acid-binding protein 7 essential to promote lipid signaling.
Asaro, A., Sinha, R., Bakun, M., Kalnytska, O., Carlo-Spiewok, A.S., Rubel, T., Rozeboom, A., Dadlez, M., Kaminska, B., Aronica, E., Malik, A.R. and Willnow, T.E.
Journal of Cell Science 134 (20): jcs258894. 15 October 2021

Is LRP2 involved in leptin transport over the blood-brain barrier and development of obesity?
Sandin, E.S., Folberth, J., Müller-Fielitz, H., Pietrzik, C.U., Herold, E., Willnow, T.E., Pfluger, P.T., Nogueiras, R., Prevot, V., Krey, T. and Schwaninger, M.
International Journal of Molecular Sciences 22 (9): 4998. 8 May 2021

Cyclin M2 (CNNM2) knockout mice show mild hypomagnesaemia and developmental defects.
Franken, G.A.C., Seker, M., Bos, C., Siemons, L.A.H., van der Eerden, B.C.J., Christ, A., Hoenderop, J.G.J., Bindels, R.J.M., Müller, D., Breiderhoff, T. and de Baaij, J.H.F.
Scientific Reports 11 (1): 8217. 15 April 2021

LRP2 controls sonic hedgehog-dependent differentiation of cardiac progenitor cells during outflow tract formation.
Christ, A., Marczenke, M. and Willnow, T.E.
Human Molecular Genetics 29 (19): 3183-3196. 1 October 2020

Cdon mutation and fetal alcohol converge on Nodal signaling in a mouse model of holoprosencephaly.
Hong, M., Christ, A., Christa, A., Willnow, T.E. and Krauss, R.S.
eLife 9 : e60351. 2 September 2020

Apolipoprotein E4 disrupts the neuroprotective action of sortilin in neuronal lipid metabolism and endocannabinoid signaling.
Asaro, A., Carlo-Spiewok, A.S., Malik, A.R., Rothe, M., Schipke, C.G., Peters, O., Heeren, J. and Willnow, T.E.
Alzheimer's & Dementia 16 (9): 1248-1258. September 2020

Concepts and software package for efficient quality control in targeted metabolomics studies - MeTaQuaC.
Kuhring, M., Eisenberger, A., Schmidt, V., Kränkel, N., Leistner, D.M., Kirwan, J. and Beule, D.
Analytical Chemistry 92 (15): 10241-10245. 4 August 2020

Direct lineage reprogramming: harnessing cell plasticity between liver and pancreas.
Ruzittu, S., Willnow, D. and Spagnoli, F.M.
Cold Spring Harbor Perspectives in Biology 12 (7): a035626. July 2020

Induced pluripotent stem cell-based disease modeling identifies ligand-induced decay of megalin as a cause of Donnai-Barrow syndrome.
Flemming, J., Marczenke, M., Rudolph, I.M., Nielsen, R., Storm, T., Ilsoe Christensen, E., Diecke, S., Emma, F. and Willnow, T.E.
Kidney International 98 (1): 159-167. July 2020

SorCS2 facilitates release of endostatin from astrocytes and controls post-stroke angiogenesis.
Malik, A.R., Lips, Janet, Gorniak-Walas, M., Broekaart, D.W.M., Asaro, A., Kuffner, M.T.C., Hoffmann, C.J., Kikhia, M., Dopatka, M., Boehm-Sturm, P., Mueller, S., Dirnagl, U., Aronica, E., Harms, C. and Willnow, T.E.
Glia 68 (6): 1304-1316. June 2020

Apolipoprotein J is a hepatokine regulating muscle glucose metabolism and insulin sensitivity.
Seo, J.A., Kang, M.C., Yang, W.M., Hwang, W.M., Kim, S.S., Hong, S.H., Heo, J.I., Vijyakumar, A., Pereira de Moura, L., Uner, A., Huang, H., Lee, S.H., Lima, I.S., Park, K.S., Kim, M.S., Dagon, Y., Willnow, T.E., Aroda, V., Ciaraldi, T.P., Henry, R.R. and Kim, Y.B.
Nature Communications 11 (1): 2024. 24 April 2020

Progranulin prevents regulatory NK cell cytotoxicity against antiviral T cells.
Huang, A., Shinde, P.V., Huang, J., Senff, T., Xu, H.C., Margotta, C., Häussinger, D., Willnow, T.E., Zhang, J., Pandyra, A.A., Timm, J., Weggen, S., Lang, K.S. and Lang, P.A.
JCI Insight 4 (17): e129856. 5 September 2019

SorCS2 controls functional expression of amino acid transporter EAAT3 and protects neurons from oxidative stress and epilepsy-induced pathology.
Malik, A.R., Szydlowska, K., Nizinska, K., Asaro, A., van Vliet, E.A., Popp, O., Dittmar, G., Fritsche-Guenther, R., Kirwan, J.A., Nykjaer, A., Lukasiuk, K., Aronica, E. and Willnow, T.E.
Cell Reports 26 (10): 2792-2804. 5 March 2019

Control of hepatic gluconeogenesis by Argonaute2.
Yan, X., Wang, Z., Bishop, C.A., Weitkunat, K., Feng, X., Tarbier, M., Luo, J., Friedländer, M.R., Burkhardt, R., Klaus, S., Willnow, T.E. and Poy, M.N.
Molecular Metabolism 18 : 15-24. December 2018

Single-cell transcriptomics characterizes cell types in the subventricular zone and uncovers molecular defects impairing adult neurogenesis.
Zywitza, V., Misios, A., Bunatyan, L., Willnow, T.E. and Rajewsky, N.
Cell Reports 25 (9): 2457-2469. 27 November 2018

Mutations in disordered regions can cause disease by creating dileucine motifs.
Meyer, K., Kirchner, M., Uyar, B., Cheng, J.Y., Russo, G., Hernandez-Miranda, L.R., Szymborska, A., Zauber, H., Rudolph, I.M., Willnow, T.E., Akalin, A., Haucke, V., Gerhardt, H., Birchmeier, C., Kühn, R., Krauss, M., Diecke, S., Pascual, J.M. and Selbach, M.
Cell 175 (1): 239-253. 20 September 2018

SORCS1 and SORCS3 control energy balance and orexigenic peptide production.
Subkhangulova, A., Malik, A.R., Hermey, G., Popp, O., Dittmar, G., Rathjen, T., Poy, M.N., Stumpf, A., Beed, P.S., Schmitz, D., Breiderhoff, T. and Willnow, T.E.
EMBO Reports 19 (4): e44810. 1 April 2018

Deletion of claudin-10 rescues claudin-16-deficient mice from hypomagnesemia and hypercalciuria.
Breiderhoff, T., Himmerkus, N., Drewell, H., Plain, A., Guenzel, D., Mutig, K., Willnow, T.E., Müller, D. and Bleich, M.
Kidney International 93 (3): 580-588. March 2018

Cadm2 regulates body weight and energy homeostasis in mice.
Yan, X., Wang, Z., Schmidt, V., Gauert, A., Willnow, T.E., Heinig, M. and Poy, M.N.
Molecular Metabolism 8 : 180-188. February 2018

Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA.
Eggert, S., Gonzalez, A.C., Thomas, C., Schilling, S., Schwarz, S.M., Tischer, C., Adam, V., Strecker, P., Schmidt, V., Willnow, T.E., Hermey, G., Pietrzik, C.U., Koo, E.H. and Kins, Stefan
Cellular and Molecular Life Sciences 75 (2): 301-322. January 2018

SORLA attenuates EphA4 signaling and amyloid, β-induced neurodegeneration.
Huang, T.Y., Zhao, Y., Jiang, L.L., Li, X., Liu, Y., Sun, Y., Piña-Crespo, J.C., Zhu, B., Masliah, E., Willnow, T.E., Pasquale, E.B. and Xu, H.
Journal of Experimental Medicine 214 (12): 3669-3685. 4 December 2017

Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1.
Rathjen, T., Yan, X., Kononenko, N.L., Ku, M.C., Song, K., Ferrarese, L., Tarallo, V., Puchkov, D., Kochlamazashvili, G., Brachs, S., Varela, L., Szigeti-Buck, K., Yi, C.X., Schriever, S.C., Tattikota, S.G., Carlo, A.S., Moroni, M., Siemens, J., Heuser, A., van der Weyden, L., Birkenfeld, A.L., Niendorf, T., Poulet, J.F.A., Horvath, T.L., Tschöp, M.H., Heinig, M., Trajkovski, M., Haucke, V. and Poy, M.N.
Nature Neuroscience 20 (8): 1096-1103. August 2017

Impaired vitreous composition and retinal pigment epithelium function in the FoxG1::LRP2 myopic mice.
Cases, O., Obry, A., Ben-Yacoub, S., Augustin, S., Joseph, A., Toutirais, G., Simonutti, M., Christ, A., Cosette, P. and Kozyraki, R.
Biochimica et Biophysica Acta - Molecular Cell Research 1863 (6): 1242-1254. June 2017

SorCS2 is required for BDNF-dependent plasticity in the hippocampus.
Glerup, S., Bolcho, U., Molgaard, S., Bøggild, S., Vaegter, C.B., Smith, A.H., Nieto-Gonzalez, J.L., Ovesen, P.L., Pedersen, L.F., Fjorback, A.N., Kjolby, M., Login, H., Holm, M.M., Andersen, O.M., Nyengaard, J.R., Willnow, T.E., Jensen, K. and Nykjaer, A.
Molecular Psychiatry 21 (12): 1740-1751. December 2016

Sortilin regulates sorting and secretion of Sonic hedgehog.
Campbell, C., Beug, S., Nickerson, P.E.B., Peng, J., Mazerolle, C., Bassett, E., Ringuette, R., Jama, F.A., Morales, C., Christ, A. and Wallace, V.A.
Journal of Cell Science 129 (20): 3832-3844. 15 October 2016

Identification of novel regulators of developmental hematopoiesis using endoglin regulatory elements as molecular probes.
Nasrallah, R., Fast, E.M., Solaimani, P., Knezevic, K., Eliades, A., Patel, R., Thambyrajah, R., Unnikrishnan, A., Thoms, J., Beck, D., Vink, C.S., Smith, A., Wong, J., Shepherd, M., Kent, D., Roychoudhuri, R., Paul, F., Klippert, J., Hammes, A., Willnow, T., Göttgens, B., Dzierzak, E., Zon, L.I., Lacaud, G., Kouskoff, V. and Pimanda, J.E.
Blood 128 (15): 1928-1939. 13 October 2016

SORLA regulates calpain-dependent degradation of synapsin.
Hartl, D., Nebrich, G., Klein, O., Stephanowitz, H., Krause, E. and Rohe, M.
Alzheimer's & Dementia 12 (9): 952-963. September 2016

SNX27 and SORLA interact to reduce amyloidogenic subcellular distribution and processing of amyloid precursor protein.
Huang, T.Y., Zhao, Y., Li, X., Wang, X., Tseng, I.C., Thompson, R., Tu, S., Willnow, T.E., Zhang, Y.W. and Xu, H.
Journal of Neuroscience 36 (30): 7996-8011. 27 July 2016

SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity.
Schmidt, V., Schulz, N., Yan, X., Schürmann, A., Kempa, S., Kern, M., Blüher, M., Poy, M.N., Olivecrona, G. and Willnow, T.E.
Journal of Clinical Investigation 126 (7): 2706-2720. 1 July 2016

Calcineurin and sorting-related receptor with A-type repeats interact to regulate the renal Na(+)-K(+)-2Cl(-) cotransporter.
Borschewski, A., Himmerkus, N., Boldt, C., Blankenstein, K.I., McCormick, J.A., Lazelle, R., Willnow, T.E., Jankowski, V., Plain, A., Bleich, M., Ellison, D.H., Bachmann, S. and Mutig, K.
Journal of the American Society of Nephrology 27 (1): 107-119. January 2016

Role of sortilin in models of autoimmune neuroinflammation.
Reuter, E., Weber, J., Paterka, M., Ploen, R., Breiderhoff, T., van Horssen, J., Willnow, T.E., Siffrin, V. and Zipp, F.
Journal of Immunology 195 (12): 5762-5769. 15 December 2015

LRP2 acts as SHH clearance receptor to protect the retinal margin from mitogenic stimuli.
Christ, A., Christa, A., Klippert, J., Eule, J.C., Bachmann, S., Wallace, V.A., Hammes, A. and Willnow, T.E.
Developmental Cell 35 (1): 36-48. 12 October 2015

Distinct functions for anterograde and retrograde sorting of SORLA in amyloidogenic processes in the brain.
Dumanis, S.B., Burgert, T., Caglayan, S., Füchtbauer, A., Füchtbauer, E.M., Schmidt, V. and Willnow, T.E.
Journal of Neuroscience 35 (37): 12703-12713. 16 September 2015

Lrp1/LDL receptor play critical roles in mannose 6-phosphate-independent lysosomal enzyme targeting.
Markmann, S., Thelen, M., Cornils, K., Schweizer, M., Brocke-Ahmadinejad, N., Willnow, T., Heeren, J., Gieselmann, V., Braulke, T. and Kollmann, K.
Traffic 16 (7): 743-759. July 2015

Foxg1-Cre mediated Lrp2 inactivation in the developing mouse neural retina, ciliary and retinal pigment epithelia models congenital high myopia.
Cases, O., Joseph, A., Obry, A., Santin, M.D., Ben-Yacoub, S., Paques, M., Amsellem-Levera, S., Bribian, A., Simonutti, M., Augustin, S., Debeir, T., Sahel, J.A., Christ, A., de Castro, F., Lehericy, S., Cosette, P. and Kozyraki, R.
PLoS ONE 10 (6): e0129518. 24 June 2015

Very low density lipoprotein receptor regulates dendritic spine formation in a RasGRF1/CaMKII dependent manner.
DiBattista, A.M., Dumanis, S.B., Song, J.M., Bu, G., Weeber, E., Rebeck, G.W. and Hoe, H.S.
Biochimica et Biophysica Acta - Molecular Cell Research 1853 (5): 904-917. May 2015

Novel codon-optimized mini-intronic plasmid for efficient, inexpensive, and xeno-free induction of pluripotency.
Diecke, S., Lu, J., Lee, J., Termglinchan, V., Kooreman, N.G., Burridge, P.W., Ebert, A.D., Churko, J.M., Sharma, A., Kay, M.A. and Wu, J.C.
Scientific Reports 5 : 8081. 28 January 2015

Growth and differentiation factor 10 (Gdf10) is involved in Bergmann glial cell development under Shh regulation.
Mecklenburg, N., Martinez-Lopez, J.E., Moreno-Bravo, J.A., Perez-Balaguer, A., Puelles, E. and Martinez, S.
Glia 62 (10): 1713-1723. October 2014

Sorting receptor sortilin-a culprit in cardiovascular and neurological diseases.
Carlo, A.S., Nykjaer, A. and Willnow, T.E.
Journal of Molecular Medicine 92 (9): 905-911. September 2014

Disturbed function of the blood-cerebrospinal fluid barrier aggravates neuro-inflammation.
Kooij, G., Kopplin, K., Blasig, R., Stuiver, M., Koning, N., Goverse, G., van der Pol, S.M.A., van het Hof, B., Gollasch, M., Drexhage, J.A.R., Reijerkerk, A., Meij, I.C., Mebius, R., Willnow, T.E., Müller, D., Blasig, I.E. and de Vries, H.E.
Acta Neuropathologica 128 (2): 267-277. August 2014

SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia.
Glerup, S., Olsen, D., Vaegter, C.B., Gustafsen, C., Sjoegaard, S.S., Hermey, G., Kjolby, M., Molgaard, S., Ulrichsen, M., Boggild, S., Skeldal, S., Fjorback, A.N., Nyengaard, J.R., Jacobsen, J., Bender, D., Bjarkam, C.R., Sørensen, E.S., Füchtbauer, E.M., Eichele, G., Madsen, P., Willnow, T.E., Petersen, C.M. and Nykjaer, A.
Neuron 82 (5): 1074-87. 4 June 2014

LRP2 mediates folate uptake in the developing neural tube.
Kur, E., Mecklenburg, N., Cabrera, R.M., Willnow, T.E. and Hammes, A.
Journal of Cell Science 127 (Pt 10): 2261-2268. 15 May 2014

Lysosomal sorting of amyloid-β by the SORLA receptor is impaired by a familial Alzheimer's disease mutation.
Caglayan, S., Takagi-Niidome, S., Liao, F., Carlo, A.S., Schmidt, V., Burgert, T., Kitago, Y., Füchtbauer, E.M., Füchtbauer, A., Holtzman, D.M., Takagi, J. and Willnow, T.E.
Science Translational Medicine 6 (223): 223ra20. 12 February 2014

SORLA-dependent and -independent functions for PACS1 in control of amyloidogenic processes.
Burgert, T., Schmidt, V., Caglayan, S., Lin, F., Füchtbauer, A., Füchtbauer, E.M., Nykjaer, A., Carlo, A.S. and Willnow, T.E.
Molecular and Cellular Biology 33 (21): 4308-4320. November 2013

Sortilin-related receptor SORCS3 is a postsynaptic modulator of synaptic depression and fear extinction.
Breiderhoff, T., Christiansen, G.B., Pallesen, L.T., Vaegter, C., Nykjaer, A., Holm, M.M., Glerup, S. and Willnow, T.E.
PLoS ONE 8 (9): e75006. 19 September 2013

SORLA-mediated trafficking of TrkB enhances the response of neurons to BDNF.
Rohe, M., Hartl, D., Fjorback, A.N., Klose, J. and Willnow, T.E.
PLoS ONE 8 (8): e72164. 19 August 2013

Sorting receptor SORLA - a trafficking path to avoid Alzheimer disease.
Willnow, T.E. and Andersen, O.M.
Journal of Cell Science 126 (Pt 13): 2751-2760. 1 July 2013

Soluble alpha-APP (sAPPalpha) regulates CDK5 expression and activity in neurons.
Hartl, D., Klatt, S., Roch, M., Konthur, Z., Klose, J., Willnow, T.E. and Rohe, M.
PLoS ONE 8 (6): e65920. 11 June 2013

Production of glycosylated soluble amyloid precursor protein alpha (sAPPalpha) in Leishmania tarentolae.
Klatt, S., Rohe, M., Alagesan, K., Kolarich, D., Konthur, Z. and Hartl, D.
Journal of Proteome Research 12 (1): 396-403. 4 January 2013

The pro-neurotrophin receptor sortilin is a major neuronal apolipoprotein E receptor for catabolism of amyloid-β peptide in the brain.
Carlo, A.S., Gustafsen, C., Mastrobuoni, G., Nielsen, M.S., Burgert, T., Hartl, D., Rohe, M., Nykjaer, A., Herz, J., Heeren, J., Kempa, S., Petersen, C.M. and Willnow, T.E.
Journal of Neuroscience 33 (1): 358-370. 2 January 2013

SorLA deficiency dissects amyloid pathology from tau and cholinergic neurodegeneration in a mouse model of Alzheimer's disease.
Capsoni, S., Carlo, A.S., Vignone, D., Amato, G., Criscuolo, C., Willnow, T.E. and Cattaneo, A.
Journal of Alzheimer's Disease 33 (2): 357-371. 2013

Endocytic receptor-mediated control of morphogen signaling.
Willnow, T.E., Christ, A. and Hammes, A.
Development 139 (23): 4311-4319. 1 December 2012

The sorting receptor sortilin exhibits a dual function in exocytic trafficking of interferon-γ and granzyme A in T cells.
Herda, S., Raczkowski, F., Mittruecker, H.W., Willimsky, G., Gerlach, K., Kuehl, A.A., Breiderhoff, T., Willnow, T.E., Doerken, B., Höpken, U.E. and Rehm, A.
Immunity 37 (5): 854-866. 16 November 2012

Deletion of claudin-10 (Cldn10) in the thick ascending limb impairs paracellular sodium permeability and leads to hypermagnesemia and nephrocalcinosis.
Breiderhoff, T., Himmerkus, N., Stuiver, M., Mutig, K., Will, C., Meij, I.C., Bachmann, S., Bleich, M., Willnow, T.E. and Mueller, D.
Proceedings of the National Academy of Sciences of the United States of America 109 (35): 14241-14246. 28 August 2012

Multi-compartmental modeling of SORLA's influence on amyloidogenic processing in Alzheimer's disease.
Lao, A., Schmidt, V., Schmitz, Y., Willnow, T.E. and Wolkenhauer, O.
BMC Systems Biology 6 (1): 74. 22 June 2012

Presymptomatic alterations in energy metabolism and oxidative stress in the APP23 mouse model of Alzheimer disease.
Hartl, D., Schuldt, V., Forler, S., Zabel, C., Klose, J. and Rohe, M.
Journal of Proteome Research 11 (6): 3295-3304. 8 May 2012

Membrane topology and intracellular processing of cyclin M2 (CNNM2).
de Baaij, J.H.F., Stuiver, M., Meij, I.C., Lainez, S., Kopplin, K., Venselaar, H., Mueller, D., Bindels, R.J.M. and Hoenderop, J.G.J.
Journal of Biological Chemistry 287 (17): 13644-13655. 20 April 2012

Identification of Alzheimer disease risk genotype that predicts efficiency of SORL1 expression in the brain.
Caglayan, S., Bauerfeind, A., Schmidt, V., Carlo, A.S., Prabakaran, T., Huebner, N. and Willnow, T.E.
Archives of Neurology 69 (3): 373-379. March 2012

LRP2 is an auxiliary SHH receptor required to condition the forebrain ventral midline for inductive signals.
Christ, A., Christa, A., Kur, E., Lioubinski, O., Bachmann, S., Willnow, T.E. and Hammes, A.
Developmental Cell 22 (2): 268-278. 14 February 2012

Retromer binds the FANSHY sorting motif in SorLA to regulate amyloid precursor protein sorting and processing.
Fjorback, A.W., Seaman, M., Gustafsen, C., Mehmedbasic, A., Gokool, S., Wu, C., Militz, D., Schmidt, V., Madsen, P., Nyengaard, J.R., Willnow, T.E., Christensen, E.I., Mobley, W.B., Nykjaer, A. and Andersen, O.M.
Journal of Neuroscience 32 (4): 1467-1480. 25 January 2012

Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease.
Schmidt, V., Baum, K., Lao, A., Rateitschak, K., Schmitz, Y., Teichmann, A., Wiesner, B., Petersen, C.M., Nykjaer, A., Wolf, J., Wolkenhauer, O. and Willnow, T.E.
EMBO Journal 31 (1): 187-200. 4 January 2012

Loss of Lrp2 in zebrafish disrupts pronephric tubular clearance but not forebrain development.
Kur, E., Christa, A., Veth, K.N., Gajera, C.R., Andrade-Navarro, M.A., Zhang, J., Willer, J.R., Gregg, R.G., Abdelilah-Seyfried, S., Bachmann, S., Link, B.A., Hammes, A. and Willnow, T.E.
Developmental Dynamics 240 (6): 1567-1577. June 2011

Kainate promotes alterations in neuronal RNA splicing machinery.
Rohe, M., Nebrich, G., Klein, O., Mao, L., Zabel, C., Klose, J. and Hartl, D.
Journal of Proteome Research 10 (4): 1459-1467. 1 April 2011

CNNM2, encoding a basolateral protein required for renal Mg(2+) handling, is mutated in dominant hypomagnesemia.
Stuiver, M., Lainez, S., Will, C., Terryn, S., Guenzel, D., Debaix, H., Sommer, K., Kopplin, K., Thumfart, J., Kampik, N.B., Querfeld, U., Willnow, T.E., Nemec, V., Wagner, C.A., Hoenderop, J.G., Devuyst, O., Knoers, N.V., Bindels, R.J., Meij, I.C. and Mueller, D.
American Journal of Human Genetics 88 (3): 333-343. 11 March 2011

Impaired aldosterone responsiveness in Corticosteroid Binding Globulin (CBG) deficient mice.
Sorensen, M.V., Praetorius, H.A., Nykjaer, A., Willnow, T.E. and Leipziger, J.
Acta Physiologica 201 (1): 169-177. January 2011

Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling.
Vaegter, C.B., Jansen, P., Fjorback, A.W., Glerup, S., Skeldal, S., Kjolby, M., Richner, M., Erdmann, B., Nyengaard, J.R., Tessarollo, L., Lewin, G.R., Willnow, T.E., Chao, M.V. and Nykjaer, A.
Nature Neuroscience 14 (1): 54-61. January 2011

Cubilin is essential for albumin reabsorption in the renal proximal tubule.
Amsellem, S., Gburek, J., Hamard, G., Nielsen, R., Willnow, T.E., Devuyst, O., Nexo, E., Verroust, P.J., Christensen, E.I. and Kozyraki, R.
Journal of the American Society of Nephrology 21 (11): 1859-1867. November 2010

Mutation of megalin leads to urinary loss of selenoprotein P and selenium deficiency in serum, liver, kidneys and brain.
Chiu-Ugalde, J., Theilig, F., Behrends, T., Drebes, J., Sieland, C., Subbarayal, P., Koehrle, J., Hammes, A., Schomburg, L. and Schweizer, U.
Biochemical Journal 431 (1): 103-111. 1 October 2010

Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export.
Kjolby, M., Andersen, O.M., Breiderhoff, T., Fjorback, A.W., Pedersen, K.M., Madsen, P., Jansen, P., Heeren, J., Willnow, T.E. and Nykjaer, A.
Cell Metabolism 12 (3): 213-223. 8 September 2010

The soluble intracellular domain of megalin does not affect renal proximal tubular function in vivo.
Christ, A., Terryn, S., Schmidt, V., Christensen, E.I., Huska, M.R., Andrade-Navarro, M.A., Huebner, N., Devuyst, O., Hammes, A. and Willnow, T.E.
Kidney International 78 (5): 473-477. September 2010

LRP2 in ependymal cells regulates BMP signaling in the adult neurogenic niche.
Gajera, C.R., Emich, H., Lioubinski, O., Christ, A., Beckervordersandforth-Bonk, R., Yoshikawa, K., Bachmann, S., Christensen, E.I., Goetz, M., Kempermann, G., Peterson, A.S., Willnow, T.E. and Hammes, A.
Journal of Cell Science 123 (Pt 11): 1922-1930. 1 June 2010

SORLA/SORL1 functionally interacts with SPAK to control renal activation of Na+-K+-Cl- cotransporter 2.
Reiche, J., Theilig, F., Rafiqi, F.H., Carlo, A.S., Militz, D., Mutig, K., Todiras, M., Christensen, E.I., Ellison, D.H., Bader, M., Nykjaer, A., Bachmann, S., Alessi, D. and Willnow, T.E.
Molecular and Cellular Biology 30 (12): 3027-3037. June 2010

Targeted deletion of murine Cldn16 identifies extra- and intrarenal compensatory mechanisms of Ca2+ and Mg2+ wasting.
Will, C., Breiderhoff, T., Thumfart, J., Stuiver, M., Kopplin, K., Sommer, K., Guenzel, D., Querfeld, U., Meij, I.C., Shan, Q., Bleich, M., Willnow, T.E. and Mueller, D.
American Journal of Physiology Renal Physiology 298 (5): F1152-F1161. May 2010

Identification of a linear epitope in sortilin that partakes in pro-neurotrophin binding.
Andersen, O.S., Boisguerin, P., Glerup, S., Skeldal, S., Volkmer, R., Willnow, T.E., Nykjaer, A. and Andersen, O.M.
Journal of Biological Chemistry 285 (16): 12210-12222. 16 April 2010

Establishment of a neuroepithelial barrier by Claudin5a is essential for zebrafish brain ventricular lumen expansion.
Zhang, J., Piontek, J., Wolburg, H., Piehl, C., Liss, M., Otten, C., Christ, A., Willnow, T.E., Blasig, I.E. and Abdelilah-Seyfried, S.
Proceedings of the National Academy of Sciences of the United States of America 107 (4): 1425-1430. 26 January 2010

SORLA/SORL1, a neuronal sorting receptor implicated in Alzheimer's disease.
Willnow, T.E., Carlo, A.S., Rohe, M. and Schmidt, V.
Reviews in the Neurosciences 21 (4): 315-329. 2010

Brain-derived neurotrophic factor reduces amyloidogenic processing through control of SORLA gene expression.
Rohe, M., Synowitz, M., Glass, R., Paul, S.M., Nykjaer, A. and Willnow, T.E.
Journal of Neuroscience 29 (49): 15472-15478. 9 December 2009

PET imaging of leptin biodistribution and metabolism in rodents and primates.
Ceccarini, G., Flavell, R.R., Butelman, E.R., Synan, M., Willnow, T.E., Bar-Dagan, M., Goldsmith, S.J., Kreek, M.J., Kothari, P., Vallabhajosula, S., Muir, T.W. and Friedman, J.M.
Cell Metabolism 10 (2): 148-159. 6 August 2009

Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11.
Spoelgen, R., Adams, K.W., Koker, M., Thomas, A.V., Andersen, O.M., Hallett, P.J., Bercury, K.K., Joyner, D.F., Deng, M., Stoothoff, W.H., Strickland, D.K., Willnow, T.E. and Hyman, B.T.
Neuroscience 158 (4): 1460-1468. 18 February 2009

Loss of LR11/SORLA enhances early pathology in a mouse model of amyloidosis: Evidence for a proximal role in Alzheimer's disease.
Dodson, S.E., Andersen, O.M., Karmali, V., Fritz, J.J., Cheng, D., Peng, J., Levey, A.I., Willnow, T.E. and Lah, J.J.
Journal of Neuroscience 28 (48): 12877-12886. 26 November 2008

Megalin contributes to the early injury of proximal tubule cells during nonselective proteinuria.
Motoyoshi, Y., Matsusaka, T., Saito, A., Pastan, I., Willnow, T.E., Mizutani, S. and Ichikawa, I.
Kidney International 74 (10): 1262-1269. 2 November 2008

Magnesium stimulates renal phosphate reabsorption.
Thumfart, J., Jung, S., Amasheh, S., Kraemer, S., Peters, H., Sommer, K., Biber, J., Murer, H., Meij, I.C., Querfeld, U., Wagner, C.A. and Mueller, D.
American Journal of Physiology Renal Physiology 295 (4): F1126-1133. 9 October 2008

A novel renal carbonic anhydrase type III plays a role in proximal tubule dysfunction.
Gailly, P., Jouret, F., Martin, D., Debaix, H., Parreira, K.S., Nishita, T., Blanchard, A., Antignac, C., Willnow, T.E., Courtoy, P.J., Scheinman, S.J., Christensen, E.I. and Devuyst, O.
Kidney International 74 (1): 52-61. 1 July 2008

Sortilin-related receptor with A-type repeats (SORLA) affects the amyloid precursor protein-dependent stimulation of ERK signaling and adult neurogenesis.
Rohe, M., Carlo, A.S., Breyhan, H., Sporbert, A., Militz, D., Schmidt, V., Wozny, C., Harmeier, A., Erdmann, B., Bales, K.R., Wolf, S.A., Kempermann, G., Paul, S.M., Schmitz, D., Bayer, T.A., Willnow, T.E. and Andersen, O.M.
Journal of Biological Chemistry 283 (21): 14826-14834. 23 May 2008

Endocytosis of sex steroids: The hypothesis of free hormones revisited.
Willnow, T.E., Hammes, A. and Nykjaer, A.
Annales d'Endocrinologie 69 (2): 101-102. April 2008

Localization of the low-density lipoprotein receptor-related protein regions involved in binding to the A2 domain of coagulation factor VIII.
Sarafanov, A.G., Makogonenko, E.M., Andersen, O.M., Mikhailenko, I.A., Ananyeva, N.M., Khrenov, A.V., Shima, M., Strickland, D.K. and Saenko, E.L.
Thrombosis and Haemostasis 98 (6): 1170-1181. December 2007

SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1.
Schmidt, V., Sporbert, A., Rohe, M., Reimer, T., Rehm, A., Andersen, O.M. and Willnow, T.E.
Journal of Biological Chemistry 282 (45): 32956-32964. 9 November 2007

Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury.
Jansen, P., Giehl, K., Nyengaard, J.R., Teng, K., Lioubinski, O., Sjoegaard, S.S., Breiderhoff, T., Gotthardt, M., Lin, F., Eilers, A., Petersen, C.M., Lewin, G.R., Hempstead, B.L., Willnow, T.E. and Nykjaer, A.
Nature Neuroscience 10 (11): 1449-1457. November 2007

L1 retrotransposition can occur early in human embryonic development.
van den Hurk, J.A., Meij, I.C., Seleme, M.C., Kano, H., Nikopoulos, K., Hoefsloot, L.H., Sistermans, E.A., de Wijs, I.J., Mukhopadhyay, A., Plomp, A.S., de Jong, P.T., Kazazian, H.H. and Cremers, F.P.
Human Molecular Genetics 16 (13): 1587-1592. 1 July 2007

Abrogation of Protein Uptake through Megalin-Deficient Proximal Tubules Does Not Safeguard against Tubulointerstitial Injury.
Theilig, F., Kriz, W., Jerichow, T., Schrade, P., Hahnel, B., Willnow, T.E., Le Hir, M. and Bachmann, S.
Journal of the American Society of Nephrology 18 (6): 1824-1834. June 2007

Endocytosis provides a major alternative pathway for lysosomal biogenesis in kidney proximal tubular cells.
Nielsen, R., Courtoy, P.J., Jacobsen, C., Dom, G., Lima, W.R., Jadot, M., Willnow, T.E., Devuyst, O. and Christensen, E.I.
Proceedings of the National Academy of Sciences of the United States of America 104 (13): 5407-5412. 27 March 2007

The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease.
Rogaeva, E., Meng, Y., Lee, J.H., Gu, Y., Kawarai, T., Zou, F., Katayama, T., Baldwin, C.T., Cheng, R., Hasegawa, H., Chen, F., Shibata, N., Lunetta, K.L., Pardossi-Piquard, R., Bohm, C., Wakutani, Y., Cupples, L.A., Cuenco, K.T., Green, R.C., Pinessi, L., Rainero, I., Sorbi, S., Bruni, A., Duara, R., Friedland, R.P., Inzelberg, R., Hampe, W., Bujo, H., Song, Y.Q., Andersen, O.M., Willnow, T.E., Graff-Radford, N., Petersen, R.C., Dickson, D., Der, S.D., Fraser, P.E., Schmitt-Ulms, G., Younkin, S., Mayeux, R., Farrer, L.A. and St George-Hyslop, P.
Nature Genetics 39 (2): 168-177. February 2007

The solution structure of the core of mesoderm development (MESD), a chaperone for members of the LDLR-family.
Koehler, C., Andersen, O.M., Diehl, A., Krause, G., Schmieder, P. and Oschkinat, H.
Journal of Structural and Functional Genomics 7 (3-4): 131-138. December 2006

Hyporesponsiveness to glucocorticoids in mice genetically deficient for the corticosteroid binding globulin.
Petersen, H.H., Andreassen, T.K., Breiderhoff, T., Braesen, J.H., Schulz, H., Gross, V., Groene, H.J., Nykjaer, A. and Willnow, T.E.
Molecular and Cellular Biology 26 (19): 7236-7245. October 2006

Binding site structure of one LRP/RAP complex - implications for a common ligand/receptor binding motif.
Jensen, G.A., Andersen, O.M., Bonvin, A.M.J.J., Bjerrum-Bohr, I., Etzerodt, M., Thogersen, H.C., O'Shea, C., Poulsen, F.M. and Kragelund, B.B.
Journal of Molecular Biology 362 (4): 700-716. 29 September 2006

Unusual clinical presentation and possible rescue of a novel Claudin-16 mutation.
Mueller, D., Kausalya, P.J., Bockenhauer, D., Tumfart, J., Meij, I.C., Dillon, M.J., van't Hoff, W. and Hunziker, W.
Journal of Clinical Endocrinology and Metabolism 91 (8): 3076-3079. August 2006

Elucidation of megalin/LRP2-dependent endocytic transport processes in the larval zebrafish pronephros.
Anzenberger, U., Bit-Avragim, N., Rohr, S., Rudolph, F., Dehmel, B., Willnow, T.E. and Abdelilah-Seyfried, S.
Journal of Cell Science 119 (Pt. 10): 2127-2137. 15 May 2006

Familial hypomagnesemia with hypercalciuria and nephrocalcinosis: blocking endocytosis restores surface expression of a novel Claudin-16 mutant that lacks the entire C-terminal cytosolic tail.
Mueller, D., Kausalya, P.J., Meij, I.C. and Hunziker, W.
Human Molecular Genetics 15 (7): 1049-1058. 1 April 2006

Apoptosis repressor with caspase recruitment domain is required for cardioprotection in response to biomechanical and ischemic stress.
Donath, S., Li, P., Willenbockel, C., Al-Saadi, N., Gross, V., Willnow, T.E., Bader, M., Martin, U., Bauersachs, J., Wollert, K.C., Dietz, R. and von Harsdorf, R.
Circulation 113 (9): 1203-1212. 7 March 2006

Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11.
Andersen, O.M., Schmidt, V., Spoelgen, R., Gliemann, J., Behlke, J., Galatis, D., McKinstry, W.J., Parker, M.W., Masters, C.L., Hyman, B.T., Cappai, R. and Willnow, T.E.
Biochemistry 45 (8): 2618-2628. 28 February 2006

Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme.
Spoelgen, R., von Arnim, C.A., Thomas, A.V., Peltan, I.D., Koker, M., Deng, A., Irizarry, M.C., Andersen, O.M., Willnow, T.E. and Hyman, B.T.
Journal of Neuroscience 26 (2): 418-428. 11 January 2006

Megalin-mediated reuptake of retinol in the kidneys of mice is essential for vitamin a homeostasis.
Raila, J., Willnow, T.E. and Schweigert, F.J.
Journal of Nutrition 135 (11): 2512-2516. 1 November 2005

Megalin is essential for renal proximal tubule reabsorption of 111In-DTPA-octreotide.
de Jong, M., Barone, R., Krenning, E., Bernard, B., Melis, M., Visser, T., Gekle, M., Willnow, T.E., Walrand, S., Jamar, F. and Pauwels, S.
Journal of Nuclear Medicine 46 : 1696-1700. 1 October 2005

Role of endocytosis in cellular uptake of sex steroids.
Hammes, A., Andreassen, T.K., Spoelgen, R., Raila, J., Huebner, N., Schulz, H., Metzger, J., Schweigert, F.J., Luppa, P.B., Nykjaer, A. and Willnow, T.E.
Cell 122 (5): 751-762. 9 September 2005

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.
Andersen, O.M., Reiche, J., Schmidt, V., Gotthardt, M., Spoelgen, R., Behlke, J., von Arnim, C.A.F., Breiderhoff, T., Jansen, P., Wu, X., Bales, K.R., Cappai, R., Masters, C.L., Gliemann, J., Mufson, E.J., Hyman, B.T., Paul, S.M., Nykjaer, A. and Willnow, T.E.
Proceedings of the National Academy of Sciences of the United States of America 102 (38): 13461-13466. 7 September 2005

The European Renal Genome Project: An integrated approach towards understanding the genetics of kidney development and disease.
Willnow, T.E., Antignac, C., Braendli, A.W., Christensen, E.I., Cox, R.D., Davidson, D., Davies, J.A., Devuyst, O., Eichele, G., Hastie, N.D., Verroust, P.J., Schedl, A. and Meij, I.C.
Organogenesis 2 (2): 42-47. April 2005

A splice variant of the Wilms' tumour suppressor Wt1 is required for normal development of the olfactory system.
Wagner, N., Wagner, K.D., Hammes, A., Kirschner, K.M., Vidal, V.R., Schedl, A. and Scholz, H.
Development 132 (6): 1327-1336. 1 January 2005

LRP2/megalin is required for patterning of the ventral telencephalon.
Spoelgen, R., Hammes, A., Anzenberger, U., Zechner, D., Andersen, O.M., Jerchow, B. and Willnow, T.E.
Development 132 (2): 405-414. 1 January 2005

Mutually-dependent localization of megalin and Dab2 in the renal proximal tubule.
Nagai, J., Christensen, E.I., Morris, S.M., Willnow, T.E., Cooper, J.A. and Nielsen, R.
American Journal of Physiology Renal Physiology 289 (3): F569-F576. 1 January 2005

α-tropomyosin mutations Asp175Asn and Glu180Gly affect cardiac function in transgenic rats in different ways.
Wernicke, D., Thiel, C., Duja-Isac, C.M., Essine, K.V., Spindler, M., Nunez, D.J.R., Plehm, R., Wessel, N., Hammes, A., Edwards, R.J., Lippoldt, A., Zacharias, U., Stroemer, H., Neubauer, S., Davies, M.J., Morano, I. and Thierfelder, L.
American Journal of Physiology Regulatory Integrative and Comparative Physiology 287 (3): R685-R695. 1 September 2004

Kidney-specific inactivation of the megalin gene impairs trafficking of renal inorganic sodium phosphate cotransporter (NaPi-IIa).
Bachmann, S., Schlichting, U., Geist, B., Mutig, K., Petsch, T., Bacic, D., Wagner, C.A., Kaissling, B., Biber, J., Murer, H. and Willnow, T.E.
Journal of the American Society of Nephrology 15 (4): 892-900. 1 April 2004

Sortilin is essential for proNGF-induced neuronal cell death.
Nykjaer, A., Lee, R., Teng, K.K., Jansen, P., Madsen, P., Nielsen, M.S., Jacobsen, C., Kliemannel, M., Schwarz, E., Willnow, T.E., Hempstead, B.L. and Petersen, C.M.
Nature 427 (6977): 843-848. 26 February 2004

Non-physiological overexpression of the low density lipoprotein receptor (LDLr) gene in the liver induces pathological intracellular lipid and cholesterol storage.
Cichon, G., Willnow, T.E., Herwig, S., Uckert, W., Loeser, P., Schmidt, H.H., Benhidjeb, T., Schlag, P.M., Schnieders, F., Niedzielska, D. and Heeren, J.
Journal of Gene Medicine 6 (2): 166-175. February 2004

Effect of Add1 gene transfer on blood pressure in reciprocal congenic strains of Milan rats.
Tripodi, G., Florio, M., Ferrandi, M., Modica, R., Zimdahl, H., Hubner, N., Ferrari, P. and Bianchi, G.
Biochemical and Biophysical Research Communications 324 (2): 562-568. 1 January 2004

Low-density lipoprotein receptor-related protein interacts with MafB, a regulator of hindbrain development.
Petersen, H.H., Hilpert, J., Jacobsen, C., Lauwers, A., Roebroek, A.J.M. and Willnow, T.E.
FEBS Letters 565 (1-3): 23-27. 1 January 2004

Applications of interspersed repeat sequence polymerase chain reaction.
Zimdahl, H., Goesele, C., Kreitler, T. and Knoblauch, M.
Methods in Molecular Biology 255 : 113-129. 2004

Renal uptake of myoglobin is mediated by the endocytic receptors megalin and cubilin.
Gburek, J., Birn, H., Verroust, P.J., Goj, B., Jacobsen, C., Moestrup, S.K., Willnow, T.E. and Christensen, E.I.
American Journal of Physiology Renal Physiology 285 (3): F451-F458. 1 September 2003

Differential binding of ligands to the apolipoprotein E receptor 2.
Andersen, O.M., Benhayon, D., Curran, T. and Willnow, T.E.
Biochemistry 42 (31): 9355-9364. 12 August 2003

Essential role of the apolipoprotein E receptor-2 in sperm development.
Andersen, O.M., Yeung, C.H., Vorum, H., Wellner, M., Andreassen, T.K., Erdmann, B., Mueller, E.C., Herz, J., Otto, A., Cooper, T.G. and Willnow, T.E.
Journal of Biological Chemistry 278 (26): 23989-23995. 27 June 2003

Hypocalcemia and osteopathy in mice with kidney-specific megalin gene defect.
Leheste, J.R., Melsen, F., Wellner, M., Jansen, P., Schlichting, U., Renner-Mueller, I., Andreassen, T.T., Wolf, E., Bachmann, S., Nykjaer, A. and Willnow, T.E.
FASEB Journal 17 (2): 247-249. February 2003

Functional interaction of megalin with the megalin-binding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule.
Heibroch Petersen, H., Hilpert, J., Militz, D., Zandler, V., Jacobsen, C., Roebroek, A.J.M. and Willnow, T.E.
Journal of Cell Science 116 : 453-461. 1 January 2003

Preferential megalin-mediated transcytosis of low-hormonogenic thyroglobulin: A control mechanism for thyroid hormone release.
Lisi, S., Pinchera, A., McCluskey, R.T., Willnow, T.E., Refetoff, S., Marcocci, C., Vitti, P., Menconi, F., Grasso, L., Luchetti, F., Collins, A.B. and Marino, M.
Proceedings of the National Academy of Sciences of the United States of America 100 (25): 14858-14863. 1 January 2003

Expression profiling confirms the role of endocytic receptor megalin in renal vitamin D-3 metabolism.
Hilpert, J., Wogensen, L., Thykjaer, T., Wellner, M., Schlichting, U., Orntoft, T.F., Bachmann, S., Nykjaer, A. and Willnow, T.E.
Kidney International 62 (5): 1672-1681. November 2002

Increased expression of renal neutral endopeptidase in severe heart failure.
Knecht, M., Pagel, I., Langenickel, T., Philipp, S., Scheuermann-Freestone, M., Willnow, T.E., Bruemmer, D., Graf, K., Dietz, R. and Willenbrock, R.
Life Sciences 71 (23): 2701-2712. 25 October 2002

Early gonadal development: exploring Wt1 and Sox9 function.
Guo, J.K., Hammes, A., Chaboissier, M.C., Vidal, V., Xing, Y., Wong, F. and Schedl, A.
Novartis Foundation Symposium 244 : 23-31. 1 March 2002

Megalin and cubilin are Endocytic receptors involved in renal clearance of hemoglobin.
Gburek, J., Verroust, P.J., Willnow, T.E., Fyfe, J.C., Nowacki, W., Jacobsen, C., Moestrup, S.K. and Christensen, E.I.
Journal of the American Society of Nephrology 13 : 423-430. 1 January 2002

Megalin deficiency offers protection from renal aminoglycoside accumulation.
Schmitz, C., Hilpert, J., Jacobsen, C., Boensch, C., Christensen, E.I., Luft, F.C. and Willnow, T.E.
Journal of Biological Chemistry 277 : 618-622. 1 January 2002

Megalin is essential for renal proximal tubule reabsorption and accumulation of transcobalamin-B-12.
Birn, H., Willnow, T.E., Nielsen, R., Norden, A.G.W., Boensch, C., Moestrup, S.K., Nexo, E. and Christensen, E.I.
American Journal of Physiology Renal Physiology 282 (3): F408-F416. 1 January 2002

A two-receptor pathway for catabolism of Clara cell secretory protein in the kidney.
Burmeister, R., Boe, I.M., Nykjaer, A., Jacobsen, C., Moestrup, S.K., Verroust, P., Christensen, E.I., Lund, J. and Willnow, T.E.
Journal of Biological Chemistry 276 (16): 13295-13301. 1 January 2001

Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D-3.
Nykjaer, A., Fyfe, J.C., Kozyraki, R., Leheste, J.R., Jacobsen, C., Nielsen, M.S., Verroust, P.J., Aminoff, M., de la Chapelle, A., Moestrup, S.K., Ray, R., Gliemann, J., Willnow, T.E. and Christensen, E.I.
Proceedings of the National Academy of Sciences of the United States of America 98 (24): 13895-13900. 1 January 2001

Efficient eukaryotic expression system for authentic human sex hormone-binding globulin.
Hilpert, J., Vorum, H., Burmeister, R., Spoelgen, R., Grishkovskaya, I., Misselwitz, R., Nykjaer, A. and Willnow, T.E.
Biochemical Journal 360 (3): 609-615. 1 January 2001

Holoprosencephaly and low molecular weight proteinuria: the human homologue of murine megalin deficiency.
Müller, D., Ankermann, T., Stephani, U., Kirschstein, M., Szelestei, T., Luft, F.C. and Willnow, T.E.
American Journal of Kidney Diseases 37 (3): 624-628. 1 January 2001

Megalin-dependent cubilin-mediated endocytosis is a major pathway for the apical uptake of transferrin in polarized epithelia.
Kozyraki, R., Fyfe, J., Verroust, P.J., Jacobsen, C., Dautry-Varsat, A., Gburek, J., Willnow, T.E., Christensen, E.I. and Moestrup, S.K.
Proceedings of the National Academy of Sciences of the United States of America 98 (22): 12491-12496. 1 January 2001

Evidence for the role of megalin in renal uptake of transthyretin.
Sousa, M.M., Norden, A.G.W., Jacobsen, C., Willnow, T.E., Christensen, E.I., Thakker, R.V., Verroust, P.J., Moestrup, S.K. and Saraiva, M.J.
Journal of Biological Chemistry 275 (49): 38176-38181. 8 December 2000

Normal blood pressure and plasma renin activity in mice lacking the renin-binding protein, a cellular renin inhibitor.
Schmitz, C., Gotthardt, M., Hinderlich, S., Leheste, J.R., Gross, V., Vorum, H., Christensen, E.I., Luft, F.C., Takahashi, S. and Willnow, T.E.
Journal of Biological Chemistry 275 (20): 15357-15362. 19 May 2000

Cubilin is an albumin binding protein important for renal tubular albumin reabsorption.
Birn, H., Fyfe, J.C., Jacobsen, C., Mounier, F., Verroust, P.J., Orskov, H., Willnow, T.E., Moestrup, S.K. and Christensen, E.I.
Journal of Clinical Investigation 105 (10): 1353-1361. May 2000

Megalin knockout mice as an animal model of low molecular weight proteinuria.
Leheste, J.R., Rolinski, B., Vorum, H., Hilpert, J., Nykjaer, A., Jacobsen, C., Aucouturier, P., Moskaug, J.O., Otto, A., Christensen, E.I. and Willnow, T.E.
American Journal of Pathology 155 (4): 1361-1370. 1 October 1999

Evidence for an essential role of megalin in transepithelial transport of retinol.
Christensen, E.I., Moskaug, J.O., Vorum, H., Jacobsen, C., Gundersen, T.E., Nykjaer, A., Blomhoff, R., Willnow, T.E. and Moestrup, S.K.
Journal of the American Society of Nephrology 10 : 685-695. 1 April 1999

Identification of megalin/gp330 as a receptor for lipoprotein(a) in vitro.
Niemeier, A., Willnow, T.E., Dieplinger, H., Jacobsen, C., Meyer, N., Hilpert, J. and Beisiegel, U.
Arteriosclerosis Thrombosis and Vascular Biology 19 (3): 552-561. March 1999

The low-density lipoprotein receptor gene family: multiple roles in lipid metabolism.
Willnow, T.E.
Journal of Molecular Medicine 77 (3): 306-315. March 1999

Megalin antagonizes activation of the parathyroid hormone receptor.
Hilpert, J., Nykjaer, A., Jacobsen, C., Wallukat, G., Nielsen, R., Moestrup, S.K., Haller, H., Luft, F.C., Christensen, E.I. and Willnow, T.E.
Journal of Biological Chemistry 274 (9): 5620-5625. 26 February 1999

An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D-3.
Nykjaer, A., Dragun, D., Walther, D., Vorum, H., Jacobsen, C., Herz, J., Melsen, F., Christensen, E.I. and Willnow, T.E.
Cell 96 (4): 507-515. 19 February 1999

beta(2)-glycoprotein-1 (apolipoprotein H) and beta(2)-glycoprotein-1-phospholipid complex harbor a recognition site for the endocytic receptor megalin.
Moestrup, S.K., Schousboe, I., Jacobsen, C., Leheste, J.R., Christensen, E.I. and Willnow, T.E.
Journal of Clinical Investigation 102 (5): 902-909. 1 September 1998

Mechanisms of hepatic chylomicron remnant clearance.
Willnow, T.E.
Diabetic Medicine 14 : S75-S80. 1 January 1997

Sustained somatic gene inactivation by viral transfer of Cre recombinase.
Rohlmann, A., Gotthardt, M., Willnow, T.E., Hammer, R.E. and Herz, J.
Nature Biotechnology 14 (11): 1562-1565. 1 November 1996

Remnant lipoproteins inhibit malaria sporozoite invasion of hepatocytes.
Sinnis, P., Willnow, T.E., Briones, M.R., Herz, J. and Nussenzweig, V.
Journal of Experimental Medicine 184 (3): 945-954. 1 September 1996

The major subunit of the asialoglycoprotein receptor is expressed on the hepatocellular surface in mice lacking the minor receptor subunit.
Braun, J.R., Willnow, T.E., Ishibashi, S., Ashwell, G. and Herz, J.
Journal of Biological Chemistry 271 (35): 21160-21166. 30 August 1996

Defective forebrain development in mice lacking gp330/megalin.
Willnow, T.E., Hilpert, J., Armstrong, S.A., Rohlmann, A., Hammer, R.E., Burns, D.K. and Herz, J.
Proceedings of the National Academy of Sciences of the United States of America 93 (16): 8460-8464. 6 August 1996

Heparan sulfate-dependent and low density lipoprotein receptor-related protein-dependent catabolic pathways for lipoprotein lipase in mouse embryonic fibroblasts.
Sehayek, E., Wang, X.X., Vlodavsky, I., Avner, R., Levkovitz, H., Olivecrona, T., Olivecrona, G., Willnow, T.E., Herz, J. and Eisenberg, S.
Israel Journal of Medical Sciences 32 (6): 449-454. June 1996

RAP, a specialized chaperone, prevents ligand-induced er retention and degradation of LDL receptor-related endocytic receptors.
Willnow, T.E., Rohlmann, A., Horton, J., Otani, H., Braun, J.R., Hammer, R.E. and Herz, J.
EMBO Journal 15 (11): 2632-2639. 1 January 1996

The low-density-lipoprotein receptor-related protein (LRP) is processed by furin in vivo and in vitro.
Willnow, T.E., Moehring, J.M., Inocencio, N.M., Moehring, T.J. and Herz, J.
Biochemical Journal 313 (Pt 1): 71-76. 1 January 1996

Functional expression of low density lipoprotein receptor- related protein is controlled by receptor-associated protein in vivo.
Willnow, T.E., Armstrong, S.A., Hammer, R.E. and Herz, J.
Proceedings of the National Academy of Sciences of the United States of America 92 (10): 4537-4541. 9 May 1995

Differential recognition of alpha1-antitrypsin-elastase and alpha1-antichymotrypsin-cathepsin G complexes by the low density lipoprotein receptor-related protein.
Poller, W., Willnow, T.E., Hilpert, J. and Herz, J.
Journal of Biological Chemistry 270 (6): 2841-2845. 10 February 1995

Functions of the LDL receptor gene family.
Herz, J. and Willnow, T.E.
Annals of the New York Academy of Sciences 737 : 14-19. 10 September 1994

Low density lipoprotein receptor-related protein is necessary for the internalization of both tissue-type plasminogen activator- inhibitor complexes and free tissue-type plasminogen activator.
Orth, K., Willnow, T.E., Herz, J., Gething, M.J. and Sambrook, J.
Journal of Biological Chemistry 269 (33): 21117-21122. 19 August 1994

Inhibition of hepatic chylomicron remnant uptake by gene transfer of a receptor antagonist.
Willnow, T.E., Sheng, Z., Ishibashi, S. and Herz, J.
Science 264 (5164): 1471-1474. 3 June 1994

Molecular dissection of ligand binding sites on the low density lipoprotein receptor-related protein.
Willnow, T.E., Orth, K. and Herz, J.
Journal of Biological Chemistry 269 (22): 15827-15832. 3 June 1994

Genetic deficiency in low density lipoprotein receptor-related protein confers cellular resistance to Pseudomonas exotoxin A. Evidence that this protein is required for uptake and degradation of multiple ligands.
Willnow, T.E. and Herz, J.
Journal of Cell Science 107 (Pt 3): 719-726. March 1994

Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance.
Willnow, T.E., Goldstein, J.L., Orth, K., Brown, M.S. and Herz, J.
Journal of Biological Chemistry 267 (36): 26172-26180. 25 December 1992

Book Section

Endocytic pathways for 25-(OH) vitamin D3.
Willnow, T.E. and Nykjaer, A.
In: Vitamin D ; vol 1. Elsevier, Amsterdam [u.a.], 153-163. ISBN 0-12-252689-9 1 January 2005

Patent

Agents for the prevention of organ damage induced by therapeutic agents.
Willnow, T.E.
US2003202974. 30 October 2003

Modulation of steroid hormone uptake [Modulierung der Aufnahme von Steroidhormonen].
Willnow, T.E. and Nykjaer, A.
EP1419394 ; WO0299438. 16 December 2002

Mittel zur Praevention von Organschaeden, die durch Aminoglykoside induziert werden.
Willnow, T.E.
DE10053506A1. 2 May 2002

Review

VPS10P domain receptors: sorting out brain health and disease.
Malik, A.R. and Willnow, T.E.
Trends in Neurosciences 43 (11): 870-885. November 2020

Excitatory amino acid transporters in physiology and disorders of the central nervous system.
Malik, A.R. and Willnow, T.E.
International Journal of Molecular Sciences 20 (22): 5671. 12 November 2019

Endocytic receptor LRP2/megalin-of holoprosencephaly and renal Fanconi syndrome.
Willnow, T.E. and Christ, A.
Pflugers Archiv 469 (7-8): 907-916. August 2017

Sorting receptor SORLA: cellular mechanisms and implications for disease.
Schmidt, V., Subkhangulova, A. and Willnow, T.E.
Cellular and Molecular Life Sciences 74 (8): 1475-1483. April 2017

Risk factor SORL1: from genetic association to functional validation in Alzheimer's disease.
Andersen, O.M., Rudolph, I.M. and Willnow, T.E.
Acta Neuropathologica 132 (5): 653-665. November 2016

LRP2, an auxiliary receptor that controls sonic hedgehog signaling in development and disease.
Christ, A., Herzog, K. and Willnow, T.E.
Developmental Dynamics 245 (5): 569-579. May 2016

Protein sorting gone wrong - VPS10P domain receptors in cardiovascular and metabolic diseases.
Schmidt, V. and Willnow, T.E.
Atherosclerosis 245 : 194-199. February 2016

Apolipoprotein E receptor pathways in Alzheimer disease.
Schmidt, V., Carlo, A.S. and Willnow, T.E.
Wiley Interdisciplinary Reviews Systems Biology and Medicine 6 (3): 255-270. May 2014

Cellular and molecular basis of cerebellar development.
Martinez, S., Andreu, A., Mecklenburg, N. and Echevarria, D.
Frontiers in Neuroanatomy 7 : 18. 26 June 2013

Sortilin: a receptor to regulate neuronal viability and function.
Nykjaer, A. and Willnow, T.E.
Trends in Neurosciences 35 (4): 261-270. April 2012

Sortilins: new players in lipoprotein metabolism.
Willnow, T.E., Kjolby, M. and Nykjaer, A.
Current Opinion in Lipidology 22 (2): 79-85. April 2011

Cellular uptake of steroid carrier proteins - mechanisms and implications.
Willnow, T.E. and Nykjaer, A.
Molecular and Cellular Endocrinology 316 (1): 93-102. 5 March 2010

VPS10P-domain receptors - regulators of neuronal viability and function.
Willnow, T.E., Petersen, C.M. and Nykjaer, A.
Nature Reviews Neuroscience 9 (12): 899-909. December 2008

Lipoproteins and their receptors in embryonic development: more than cholesterol clearance.
Willnow, T.E., Hammes, A. and Eaton, S.
Development 134 (18): 3239-3249. September 2007

Lipoprotein receptors in Alzheimer's disease.
Andersen, O.M. and Willnow, T.E.
Trends in Neurosciences 29 (12): 687-694. December 2006

p75NTR - live or let die.
Nykjaer, A., Willnow, T.E. and Petersen, C.M.
Current Opinion in Neurobiology 15 (1): 49-57. 1 January 2005

From holoprosencephaly to osteopathology: role of multifunctional endocytic receptors in absorptive epithelia.
Mueller, D., Nykjaer, A. and Willnow, T.E.
Annals of Medicine 35 (5): 290-299. 2003

The low-density lipoprotein receptor gene family: a cellular Swiss army knife?
Nykjaer, A. and Willnow, T.E.
Trends in Cell Biology 12 (6): 273-280. 1 June 2002

Pathways for kidney-specific uptake of the steroid hormone 25-hydroxyvitamin D(3).
Willnow, T.E. and Nykjaer, A.
Current Opinion in Lipidology 13 (3): 255-260. June 2002

Cellular signalling by lipoprotein receptors.
Herz, J., Gotthardt, M. and Willnow, T.E.
Current Opinion in Lipidology 11 (2): 161-166. 1 April 2000

Essential role of megalin in renal proximal tubule for vitamin homeostasis.
Christensen, E.I. and Willnow, T.E.
Journal of the American Society of Nephrology 10 : 2224-2236. 1 October 1999

Lipoprotein receptors: new roles for ancient proteins.
Willnow, T.E., Nykjaer, A. and Herz, J.
Nature Cell Biology 1 : E157-E162. 1 October 1999

Receptor-associated protein (RAP): A specialized chaperone for endocytic receptors.
Willnow, T.E.
Biological Chemistry 379 (8-9): 1025-1031. August 1998

Animal models for disorders of hepatic lipoprotein metabolism.
Willnow, T.E. and Herz, J.
Journal of Molecular Medicine 73 (5): 213-220. May 1995

Lipoprotein and receptor interactions in vivo.
Herz, J. and Willnow, T.E.
Current Opinion in Lipidology 6 (2): 97-103. April 1995

Homologous recombination for gene replacement in mouse cell lines.
Willnow, T.E. and Herz, J.
Methods in Cell Biology 43 (Pt A): 305-334. 1994

Letter

Response: Cellular uptake of sex steroid hormones.
Willnow, T.E. and Nykjaer, A.
Cell 124 (3): 456-457. 10 February 2006

Cholesterol, hedgehog and embryogenesis.
Herz, J., Willnow, T.E. and Farese, R.V.
Nature Genetics 15 (2): 123-124. February 1997

Editorial

Nanotubes, the fast track to treatment of Dent disease?
Willnow, T.E.
Kidney International 91 (4): 776-778. April 2017

Sortilin, a novel APOE receptor implicated in Alzheimer disease.
Carlo, A.S.
Prion 7 (5): 378-382. September 2013

EUNEFRON, the European Network for the Study of Orphan Nephropathies.
Devuyst, O., Meij, I., Jeunemaitre, X., Ronco, P., Antignac, C., Christensen, E.I., Knoers, N.V., Levtchenko, E.N., Deen, P.M., Mueller, D., Wagner, C.A., Rampoldi, L. and van't Hoff, W.G.
Nephrology Dialysis Transplantation 24 (7): 2011-2015. July 2009

Pin-pointing APP processing.
Willnow, T.E. and Andersen, O.M.
Molecular Interventions 6 (3): 137-139. June 2006

Preprint

Interaction of sortilin with apolipoprotein E3 enables neurons to use long-chain fatty acids as alternative metabolic fuel.
Greda, A.K., Gomes, J.P., Zurawska-Plaksej, E., Fritsche-Guenther, R., Rudolph, I.M., Telugu, N.S., Cömert, C., Kirwan, J., Kunz, S., Rothe, M., Diecke, S., Bross, P. and Willnow, T.E.
bioRxiv : 2024.06.10.598173. 10 June 2024

Cdon mutation and fetal alcohol converge on nodal signaling in a gene-environment interaction model of holoprosencephaly.
Hong, M., Christ, A., Christa, A., Willnow, T.E. and Krauss, R.S.
bioRxiv : 2020.04.30.070870. 1 May 2020