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Mice with renal-specific alterations 1 of stem cell-associated signaling develop symptoms of chronic kidney disease but surprisingly no tumors.
Myszczyszyn, A. 
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PLoS ONE 19
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21 March 2024
Impaired Plakophilin-2 in obesity breaks cell cycle dynamics to breed adipocyte senescence.
Lluch, A. ORCID: https://orcid.org/0000-0003-4216-4436, Latorre, J., Serena-Maione, A. ORCID: https://orcid.org/0000-0003-1460-7033, Espadas, I. ORCID: https://orcid.org/0000-0002-9811-9717, Caballano-Infantes, E. ORCID: https://orcid.org/0000-0001-8269-9158, Moreno-Navarrete, J.M. ORCID: https://orcid.org/0000-0002-2883-511X, Oliveras-Cañellas, N. ORCID: https://orcid.org/0000-0002-7758-3326, Ricart, W., Malagón, M.M. ORCID: https://orcid.org/0000-0002-2419-2727, Martin-Montalvo, A. ORCID: https://orcid.org/0000-0002-3886-5355, Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Szymanski, W. ORCID: https://orcid.org/0000-0002-1202-3299, Graumann, J. ORCID: https://orcid.org/0000-0002-3015-5850, Gómez-Serrano, M. ORCID: https://orcid.org/0000-0002-9669-091X, Sommariva, E. ORCID: https://orcid.org/0000-0003-2172-4051, Fernández-Real, J.M. ORCID: https://orcid.org/0000-0002-7442-9323 and Ortega, F.J. ORCID: https://orcid.org/0000-0003-2111-769X
Nature Communications 14
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22 August 2023
Concomitant deletion of Ptpn6 and Ptpn11 in T cells fails to improve anticancer responses.
Ventura, P.M.O., Gakovic, M., Fischer, B.A., Spinelli, L. ORCID: https://orcid.org/0000-0002-5801-6297, Rota, G., Pathak, S. ORCID: https://orcid.org/0000-0001-9871-2214, Khameneh, H.J. ORCID: https://orcid.org/0000-0002-1737-0388, Zenobi, A. ORCID: https://orcid.org/0000-0003-2837-7638, Thomson, S., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Cantrell, D.A. and Guarda, G. ORCID: https://orcid.org/0000-0001-9243-6116
EMBO Reports 23
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7 November 2022
Targeting Wnt/β-catenin signaling by TET1/FOXO4 inhibits metastatic spreading and self-renewal of cancer stem cells in gastric cancer.
Qi, J., Cui, D., Wu, Q.N., Zhao, Q. ORCID: https://orcid.org/0000-0002-8683-6145, Chen, Z.H., Li, L., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Yu, Y. and Tao, R.
Cancers 14
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Targeting SHP2 phosphatase in breast cancer overcomes RTK-mediated resistance to PI3K inhibitors.
Heynen, G.J.J.E. ORCID: https://orcid.org/0000-0001-7721-5710, Lisek, K. ORCID: https://orcid.org/0000-0002-2406-8830, Vogel, R., Wulf-Goldenberg, A., Alcaniz, J., Montaudon, E., Marangoni, E. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Breast Cancer Research 24
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1 April 2022
Epigenetic modifier balances Mapk and Wnt signalling in differentiation of goblet and Paneth cells.
Grinat, J. ORCID: https://orcid.org/0000-0003-0152-4941, Kosel, F., Goveas, N. ORCID: https://orcid.org/0000-0002-2531-5514, Kranz, A. ORCID: https://orcid.org/0000-0002-7481-0220, Alexopoulou, D. ORCID: https://orcid.org/0000-0002-3715-1756, Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370, Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761, Stewart, A.F. and Heuberger, J. ORCID: https://orcid.org/0000-0001-7205-732X
Life Science Alliance 5
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April 2022
MLL1 is required for maintenance of intestinal stem cells.
Goveas, N. ORCID: https://orcid.org/0000-0002-2531-5514, Waskow, C. ORCID: https://orcid.org/0000-0003-3261-0922, Arndt, K., Heuberger, J. ORCID: https://orcid.org/0000-0001-7205-732X, Zhang, Q. ORCID: https://orcid.org/0000-0001-8292-938X, Alexopoulou, D. ORCID: https://orcid.org/0000-0002-3715-1756, Dahl, A., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Anastassiadis, K. ORCID: https://orcid.org/0000-0002-9814-0559, Stewart, A.F. ORCID: https://orcid.org/0000-0002-4754-1707 and Kranz, A. ORCID: https://orcid.org/0000-0002-7481-0220
PLoS Genetics 17
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3 December 2021
NF-κB determines Paneth versus goblet cell fate decision in the small intestine.
Brischetto, C. ORCID: https://orcid.org/0000-0001-9167-3291, Krieger, K., Klotz, C., Krahn, I., Kunz, S. ORCID: https://orcid.org/0000-0002-0131-3506, Kolesnichenko, M. ORCID: https://orcid.org/0000-0001-7366-9061, Mucka, P. ORCID: https://orcid.org/0000-0003-2125-0634, Heuberger, J. ORCID: https://orcid.org/0000-0001-7205-732X, Scheidereit, C. ORCID: https://orcid.org/0000-0002-0446-6129 and Schmidt-Ullrich, R. ORCID: https://orcid.org/0000-0002-2472-6530
Development 148
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Oxidized LDL-dependent pathway as new pathogenic trigger in arrhythmogenic cardiomyopathy.
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EMBO Molecular Medicine 13
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7 September 2021
Beneficial effect of voluntary physical exercise in Plakophilin2 transgenic mice.
Hammer, K.P. ORCID: https://orcid.org/0000-0003-2015-0682, Mustroph, J. ORCID: https://orcid.org/0000-0001-9668-7852, Stauber, T., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Wagner, S. and Maier, L.S.
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4 June 2021
Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling.
Kamdem, N., Roske, Y. ORCID: https://orcid.org/0000-0001-6237-388X, Kovalskyy, D. ORCID: https://orcid.org/0000-0002-1143-8724, Platonov, M.O., Balinskyi, O., Kreuchwig, A., Saupe, J. ORCID: https://orcid.org/0000-0003-4110-9881, Fang, L., Diehl, A., Schmieder, P. ORCID: https://orcid.org/0000-0001-9968-9327, Krause, G., Rademann, J. ORCID: https://orcid.org/0000-0001-6678-3165, Heinemann, U. ORCID: https://orcid.org/0000-0002-8191-3850, Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Oschkinat, H. ORCID: https://orcid.org/0000-0002-4384-9544
Magnetic Resonance 2
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2 June 2021
High Yap and Mll1 promote a persistent regenerative cell state induced by Notch signaling and loss of p53.
Heuberger, J. ORCID: https://orcid.org/0000-0001-7205-732X, Grinat, J. ORCID: https://orcid.org/0000-0003-0152-4941, Kosel, F., Liu, L., Kunz, S. ORCID: https://orcid.org/0000-0002-0131-3506, Vidal, R.O. ORCID: https://orcid.org/0000-0003-4217-2014, Keil, M. ORCID: https://orcid.org/0000-0002-6009-9845, Haybaeck, J. ORCID: https://orcid.org/0000-0001-5518-3359, Robine, S. ORCID: https://orcid.org/0000-0002-8885-0389, Louvard, D. ORCID: https://orcid.org/0000-0001-5956-7755, Regenbrecht, C. ORCID: https://orcid.org/0000-0001-9494-5977, Sporbert, A. ORCID: https://orcid.org/0000-0002-3738-1295, Sauer, S. ORCID: https://orcid.org/0000-0002-4794-3693, von Eyss, B. ORCID: https://orcid.org/0000-0002-4731-6841, Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761 and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Proceedings of the National Academy of Sciences of the United States of America 118
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The discriminative ability of Prostate Health Index to detect prostate cancer is enhanced in combination with miR-222-3p.
Tölle, A., Jung, K., Friedersdorff, F., Maxeiner, A., Lein, M., Fendler, A. ORCID: https://orcid.org/0000-0002-7267-0981 and Stephan, C.
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9 April 2021
YAP and β-catenin cooperate to drive oncogenesis in basal breast cancer.
Quinn, H.M. ORCID: https://orcid.org/0000-0002-1336-5709, Vogel, R., Popp, O. ORCID: https://orcid.org/0000-0001-6240-4666, Mertins, P. ORCID: https://orcid.org/0000-0002-2245-528X, Lan, L., Messerschmidt, C. ORCID: https://orcid.org/0000-0001-8632-656X, Landshammer, A., Lisek, K. ORCID: https://orcid.org/0000-0002-2406-8830, Château-Joubert, S., Marangoni, E., Koren, E., Fuchs, Y. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Cancer Research 81
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April 2021
The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness.
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Nature Communications 11
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21 December 2020
From pyrazolones to azaindoles: evolution of active-site SHP2 inhibitors based on scaffold hopping and bioisosteric replacement.
Mostinski, Y., Heynen, G.J.J.E. ORCID: https://orcid.org/0000-0001-7721-5710, López-Alberca, M.P., Paul, J., Miksche, S., Radetzki, S. ORCID: https://orcid.org/0000-0003-2688-2868, Schaller, D., Shanina, E., Seyffarth, C., Kolomeets, Y., Ziebart, N., de Schryver, J., Oestreich, S., Neuenschwander, M. ORCID: https://orcid.org/0000-0002-3114-7975, Roske, Y. ORCID: https://orcid.org/0000-0001-6237-388X, Heinemann, U. ORCID: https://orcid.org/0000-0002-8191-3850, Rademacher, C., Volkamer, A. ORCID: https://orcid.org/0000-0002-3760-580X, von Kries, J.P. ORCID: https://orcid.org/0000-0003-4716-4988, Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Nazaré, M. ORCID: https://orcid.org/0000-0002-1602-2330
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10 December 2020
Circular RNAs and their linear transcripts as diagnostic and prognostic tissue biomarkers in prostate cancer after prostatectomy in combination with clinicopathological factors.
Rochow, H., Jung, M., Weickmann, S., Ralla, B., Stephan, C., Elezkurtaj, S., Kilic, E., Zhao, Z., Jung, K., Fendler, A. ORCID: https://orcid.org/0000-0002-7267-0981 and Franz, A.
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Instability of circular RNAs in clinical tissue samples impairs their reliable expression analysis using RT-qPCR: from the myth of their advantage as biomarkers to reality.
Rochow, H., Franz, A., Jung, M., Weickmann, S., Ralla, B., Kilic, E., Stephan, C., Fendler, A. ORCID: https://orcid.org/0000-0002-7267-0981 and Jung, K.
Theranostics 10
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23 July 2020
Identification of miR-21-5p and miR-210-3p serum levels as biomarkers for patients with papillary renal cell carcinoma: a multicenter analysis.
Kalogirou, C., Ellinger, J., Kristiansen, G., Hatzichristodoulou, G., Kübler, H., Kneitz, B., Busch, J. and Fendler, A. ORCID: https://orcid.org/0000-0002-7267-0981
Translational Andrology and Urology 9
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June 2020
Tracing tumorigenesis in a solid tumor model at single-cell resolution.
Praktiknjo, S.D. ORCID: https://orcid.org/0000-0002-0186-5271, Obermayer, B. ORCID: https://orcid.org/0000-0002-9116-630X, Zhu, Q., Fang, L., Liu, H. ORCID: https://orcid.org/0009-0007-4871-452X, Quinn, H. ORCID: https://orcid.org/0000-0002-1336-5709, Stoeckius, M. ORCID: https://orcid.org/0000-0002-5658-029X, Kocks, C. ORCID: https://orcid.org/0000-0003-1749-3334, Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Rajewsky, N. ORCID: https://orcid.org/0000-0002-4785-4332
Nature Communications 11
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20 February 2020
Inhibiting WNT and NOTCH in renal cancer stem cells and the implications for human patients.
Fendler, A. ORCID: https://orcid.org/0000-0002-7267-0981, Bauer, D. ORCID: https://orcid.org/0000-0002-2933-4333, Busch, J., Jung, K. ORCID: https://orcid.org/0000-0001-9797-5362, Wulf-Goldenberg, A., Kunz, S. ORCID: https://orcid.org/0000-0002-0131-3506, Song, K. ORCID: https://orcid.org/0000-0001-6216-8157, Myszczyszyn, A. ORCID: https://orcid.org/0009-0006-6152-5451, Elezkurtaj, S. ORCID: https://orcid.org/0000-0003-1219-6517, Erguen, B., Jung, S., Chen, W. ORCID: https://orcid.org/0000-0003-3263-1627 and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Nature Communications 11
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Decreased microglial Wnt/β-catenin signalling drives microglial pro-inflammatory activation in the developing brain.
Van Steenwinckel, J. ORCID: https://orcid.org/0000-0003-3463-4856, Schang, A.L., Krishnan, M.L., Degos, V., Delahaye-Duriez, A., Bokobza, C., Csaba, Z., Verdonk, F., Montané, A., Sigaut, S., Hennebert, O., Lebon, S., Schwendimann, L., Le Charpentier, T., Hassan-Abdi, R., Ball, G. ORCID: https://orcid.org/0000-0003-3509-1435, Aljabar, P., Saxena, A., Holloway, R.K., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Baud, O., Rowitch, D., Miron, V., Chretien, F., Leconte, C. ORCID: https://orcid.org/0000-0002-8206-9938, Besson, V.C., Petretto, E.G., Edwards, A.D., Hagberg, H., Soussi-Yanicostas, N., Fleiss, B. and Gressens, P.
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A novel predictor tool of biochemical recurrence after radical prostatectomy based on a five-microRNA tissue signature.
Zhao, Z., Weickmann, S., Jung, M., Lein, M., Kilic, E., Stephan, C., Erbersdobler, A., Fendler, A. ORCID: https://orcid.org/0000-0002-7267-0981 and Jung, K.
Cancers 11
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Circular RNAs in clear cell renal cell carcinoma: their microarray-based identification, analytical validation, and potential use in a clinico-genomic model to improve prognostic accuracy.
Franz, A., Ralla, B., Weickmann, S., Jung, M., Rochow, H., Stephan, C., Erbersdobler, A., Kilic, E., Fendler, A. ORCID: https://orcid.org/0000-0002-7267-0981 and Jung, K.
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Spatially restricted stromal Wnt signaling restrains prostate epithelial progenitor growth through direct and indirect mechanisms.
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Cell Stem Cell 24
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2 May 2019
KLF4 functions as an oncogene in promoting cancer stem cell-like characteristics in osteosarcoma cells.
Qi, X.T., Li, Y.L., Zhang, Y.Q., Xu, T., Lu, B., Fang, L., Gao, J.Q., Yu, L.S., Zhu, D.F., Yang, B., He, Q.J. and Ying, M.D.
Acta Pharmacologica Sinica 40
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Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells.
Niogret, C., Miah, S.M.S., Rota, G., Fonta, N.P., Wang, H., Held, W. ORCID: https://orcid.org/0000-0003-3292-1536, Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Sexl, V., Yang, W., Vivier, E. ORCID: https://orcid.org/0000-0001-7022-8287, Ho, P.C. ORCID: https://orcid.org/0000-0003-3078-3774, Brossay, L. ORCID: https://orcid.org/0000-0002-7497-8488 and Guarda, G. ORCID: https://orcid.org/0000-0001-9243-6116
Nature Communications 10
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29 March 2019
A C/EBPα-Wnt connection in gut homeostasis and carcinogenesis.
Heuberger, J. ORCID: https://orcid.org/0000-0001-7205-732X, Hill, U., Förster, S., Zimmermann, K., Malchin, V., Kühl, A.A., Stein, U. ORCID: https://orcid.org/0000-0001-7006-282X, Vieth, M., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Leutz, A. ORCID: https://orcid.org/0000-0001-8259-927X
Life Science Alliance 2
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February 2019
The Wnt-driven Mll1 epigenome regulates salivary gland and head and neck cancer.
Zhu, Q., Fang, L., Heuberger, J. ORCID: https://orcid.org/0000-0001-7205-732X, Kranz, A., Schipper, J., Scheckenbach, K., Oliveira Vidal, R. ORCID: https://orcid.org/0000-0003-4217-2014, Sunaga-Franze, D.Y. ORCID: https://orcid.org/0000-0002-6851-9162, Müller, M., Wulf-Goldenberg, A., Sauer, S. ORCID: https://orcid.org/0000-0002-4794-3693 and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Cell Reports 26
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8 January 2019
Keratinocyte-specific ablation of protease-activated receptor-2 prevents gingival inflammation and bone loss in a mouse model of periodontal disease.
Francis, N., Ayodele, B.A., O'Brien-Simpson, N.M., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Pike, R.N., Pagel, C.N. and Mackie, E.J. ORCID: https://orcid.org/0000-0002-8057-5407
Cellular Microbiology 20
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miR-9-5p in nephrectomy specimens is a potential predictor of primary resistance to first-line treatment with tyrosine kinase inhibitors in patients with metastatic renal cell carcinoma.
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The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis.
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Nature Communications 9
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14 August 2018
Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase.
Ruess, D.A. ORCID: https://orcid.org/0000-0003-4371-2246, Heynen, G.J. ORCID: https://orcid.org/0000-0001-7721-5710, Ciecielski, K.J., Ai, J., Berninger, A., Kabacaoglu, D., Görgülü, K. ORCID: https://orcid.org/0000-0002-1613-1422, Dantes, Z., Wörmann, S.M., Diakopoulos, K.N., Karpathaki, A.F., Kowalska, M., Kaya-Aksoy, E., Song, L., Zeeuw van der Laan, E.A. ORCID: https://orcid.org/0000-0002-2784-5236, López-Alberca, M.P., Nazaré, M. ORCID: https://orcid.org/0000-0002-1602-2330, Reichert, M., Saur, D., Erkan, M.M., Hopt, U.T., Sainz, B., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Schmid, R.M., Lesina, M. and Algül, H.
Nature Medicine 24
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Shp-2 is dispensable for establishing T cell exhaustion and for PD-1 signaling in vivo.
Rota, G., Niogret, C., Dang, A.T., Barros, C.R., Fonta, N.P., Alfei, F., Morgado, L., Zehn, D., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Vivier, E. and Guarda, G.
Cell Reports 23
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Lenalidomide regulates CNS autoimmunity by promoting M2 macrophages polarization.
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Cell Death & Disease 9
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14 February 2018
Characterization and structural determination of a new anti-MET function-blocking antibody with binding epitope distinct from the ligand binding domain.
DiCara, D.M., Chirgadze, D.Y., Pope, A.R., Karatt-Vellatt, A., Winter, A. ORCID: https://orcid.org/0000-0002-8602-8009, Slavny, P., van den Heuvel, J. ORCID: https://orcid.org/0000-0001-5085-4010, Parthiban, K., Holland, J., Packman, L.C., Mavria, G., Hoffmann, J. ORCID: https://orcid.org/0000-0003-3880-1658, Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Gherardi, E. and McCafferty, J.
Scientific Reports 7
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21 August 2017
Cancer stem cells regulate cancer-associated fibroblasts via activation of Hedgehog signaling in mammary gland tumors.
Valenti, G., Quinn, H.M. ORCID: https://orcid.org/0000-0002-1336-5709, Heynen, G.J.J.E. ORCID: https://orcid.org/0000-0001-7721-5710, Lan, L. ORCID: https://orcid.org/0000-0002-8409-4336, Holland, J.D., Vogel, R., Wulf-Goldenberg, A. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Cancer Research 77
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15 April 2017
New Wnt/β-catenin target genes promote experimental metastasis and migration of colorectal cancer cells through different signals.
Qi, J., Yu, Y. ORCID: https://orcid.org/0000-0003-1928-2514, Akilli Öztürk, Ö., Holland, J.D., Besser, D. ORCID: https://orcid.org/0000-0002-4958-9624, Fritzmann, J., Wulf-Goldenberg, A., Eckert, K., Fichtner, I. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Gut 65
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October 2016
RNF4-dependent oncogene activation by protein stabilization.
Thomas, J.J., Abed, M., Heuberger, J. ORCID: https://orcid.org/0000-0001-7205-732X, Novak, R., Zohar, Y., Beltra-Lopez, A.P., Trausch-Azar, J.S., Ilagan, M.X.G., Benhamou, D., Dittmar, G. ORCID: https://orcid.org/0000-0003-3647-8623, Kopan, R., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Schwartz, A.L. and Orian, A.
Cell Reports 16
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20 September 2016
The A-kinase anchoring protein (AKAP) glycogen synthase kinase 3β interaction protein (GSKIP) regulates β-catenin through its interactions with both protein kinase A (PKA) and GSK3β.
Dema, A., Schröter, M.F., Perets, E., Skroblin, P. ORCID: https://orcid.org/0000-0003-0321-3493, Moutty, M.C., Deàk, V.A., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
Journal of Biological Chemistry 291
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9 September 2016
Effects of silibinin on growth and invasive properties of human ovarian carcinoma cells through suppression of heregulin/HER3 pathway.
Momeny, M., Ghasemi, R., Valenti, G., Miranda, M., Zekri, A., Zarrinrad, G., Javadikooshesh, S., Yaghmaie, M., Alimoghaddam, K., Ghavamzadeh, A. and Ghaffari, S.H.
Tumor Biology 37
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March 2016
A small-molecule antagonist of the β-catenin/TCF4 interaction blocks the self-renewal of cancer stem cells and suppresses tumorigenesis.
Fang, L., Zhu, Q., Neuenschwander, M. ORCID: https://orcid.org/0000-0002-3114-7975, Specker, E. ORCID: https://orcid.org/0000-0002-9471-9520, Wulf-Goldenberg, A., Weis, W.I., von Kries, J.P. ORCID: https://orcid.org/0000-0003-4716-4988 and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Cancer Research 76
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15 February 2016
Diagnostic and prognostic potential of circulating cell-free genomic and mitochondrial DNA fragments in clear cell renal cell carcinoma patients.
Lu, H., Busch, J., Jung, M., Rabenhorst, S., Ralla, B., Kilic, E., Mergemeier, S., Budach, N., Fendler, A. ORCID: https://orcid.org/0000-0002-7267-0981 and Jung, K.
Clinica Chimica Acta 452
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15 January 2016
Developing antagonists for the Met-HGF/SF protein-protein interaction using a fragment-based approach.
Winter, A., Sigurdardottir, A.G., DiCara, D., Valenti, G., Blundell, T.L. and Gherardi, E.
Molecular Cancer Therapeutics 15
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January 2016
Gab1 and Mapk signaling are essential in the hair cycle and hair follicle stem cell quiescence.
Akilli Öztürk, Ö., Pakula, H., Chmielowiec, J., Qi, J., Stein, S., Lan, L., Sasaki, Y., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Cell Reports 13
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20 October 2015
Piwi-interacting RNAs as novel prognostic markers in clear cell renal cell carcinomas.
Busch, J., Ralla, B., Jung, M., Wotschofsky, Z., Trujillo-Arribas, E., Schwabe, P., Kilic, E., Fendler, A. ORCID: https://orcid.org/0000-0002-7267-0981 and Jung, K.
Journal of Experimental & Clinical Cancer Research 34
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14 June 2015
Shp2 signaling suppresses senescence in PyMT-induced mammary gland cancer in mice.
Lan, L., Holland, J.D., Qi, J., Grosskopf, S., Rademann, J. ORCID: https://orcid.org/0000-0001-6678-3165, Vogel, R., Gyoerffy, B., Wulf-Goldenberg, A. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
EMBO Journal 34
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3 June 2015
Selective inhibitors of the protein tyrosine phosphatase SHP2 block cellular motility and growth of cancer cells in vitro and in vivo.
Grosskopf, S., Eckert, C., Arkona, C., Radetzki, S. ORCID: https://orcid.org/0000-0003-2688-2868, Böhm, K., Heinemann, U. ORCID: https://orcid.org/0000-0002-8191-3850, Wolber, G., von Kries, J.P. ORCID: https://orcid.org/0000-0003-4716-4988, Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Rademann, J. ORCID: https://orcid.org/0000-0001-6678-3165
ChemMedChem 10
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May 2015
Heregulin-HER3-HER2 signaling promotes matrix metalloproteinase-dependent blood-brain-barrier transendothelial migration of human breast cancer cell lines.
Momeny, M., Saunus, J.M., Marturana, F., McCart Reed, A.E., Black, D., Sala, G., Iacobelli, S., Holland, J.D., Yu, D., Da Silva, L., Simpson, P.T., Khanna, K.K., Chenevix-Trench, G. and Lakhani, S.R.
Oncotarget 6
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19 February 2015
Global increase of p16INK4a in APC-deficient mouse liver drives clonal growth of p16INK4a negative tumors.
Ueberham, E., Glöckner, P., Göhler, C., Straub, B.K., Teupser, D., Schönig, K., Braeuning, A., Höhn, A.K., Jerchow, B., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Gaunitz, F., Arendt, T., Sansom, O., Gebhardt, R. and Ueberham, U.
Molecular Cancer Research 13
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February 2015
Afadin requirement for cytokine expressions in keratinocytes during chemically induced inflammation in mice.
Yoshida, T., Iwata, T., Takai, Y., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Yamato, M. and Okano, T.
Genes to Cells 19
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November 2014
The BCL9-2 proto-oncogene governs estrogen receptor alpha expression in breast tumorigenesis.
Zatula, N., Wiese, M., Bunzendahl, J., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Perske, C., Bleckmann, A. and Brembeck, F.H.
Oncotarget 5
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30 August 2014
Wnt-Fzd signaling sensitizes peripheral sensory neurons via distinct noncanonical pathways.
Simonetti, M., Agarwal, N., Stösser, S., Bali, K.K., Karaulanov, E., Kamble, R., Pospisilova, B., Kurejova, M., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Niehrs, C., Heppenstall, P. and Kuner, R.
Neuron 83
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2 July 2014
Shp2/MAPK signaling controls goblet/paneth cell fate decisions in the intestine.
Heuberger, J. ORCID: https://orcid.org/0000-0001-7205-732X, Kosel, F., Qi, J., Grossmann, K.S., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Proceedings of the National Academy of Sciences of the United States of America 111
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4 March 2014
Activation of MAPK overrides the termination of myelin growth and replaces Nrg1/ErbB3 signals during Schwann cell development and myelination.
Sheean, M.E. ORCID: https://orcid.org/0000-0003-3055-0495, McShane, E. ORCID: https://orcid.org/0000-0002-7806-2063, Cheret, C. ORCID: https://orcid.org/0000-0001-7382-0403, Walcher, J., Müller, T. ORCID: https://orcid.org/0000-0001-8096-1853, Wulf-Goldenberg, A., Hoelper, S., Garratt, A.N. ORCID: https://orcid.org/0000-0001-9631-3041, Krüger, M., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370, Meijer, D., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Lewin, G.R. ORCID: https://orcid.org/0000-0002-2890-6352, Selbach, M. ORCID: https://orcid.org/0000-0003-2454-8751 and Birchmeier, C. ORCID: https://orcid.org/0000-0002-2041-8872
Genes & Development 28
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1 February 2014
Combined Wnt/β-catenin, met, and CXCL12/CXCR4 signals characterize basal breast cancer and predict disease outcome.
Holland, J.D., Györffy, B., Vogel, R., Eckert, K., Valenti, G., Fang, L., Lohneis, P., Elezkurtaj, S., Ziebold, U. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Cell Reports 5
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12 December 2013
Wnt/Rspondin/β-catenin signals control axonal sorting and lineage progression in Schwann cell development.
Grigoryan, T., Stein, S., Qi, J., Wende, H. ORCID: https://orcid.org/0000-0002-9168-8095, Garratt, A.N. ORCID: https://orcid.org/0000-0001-9631-3041, Nave, K.A., Birchmeier, C. ORCID: https://orcid.org/0000-0002-2041-8872 and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Proceedings of the National Academy of Sciences of the United States of America 110
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5 November 2013
MicroRNA signature helps distinguish early from late biochemical failure in prostate cancer.
Lichner, Z., Fendler, A. ORCID: https://orcid.org/0000-0002-7267-0981, Saleh, C., Nasser, A.N., Boles, D., Al-Haddad, S., Kupchak, P., Dharsee, M., Nuin, P.S., Evans, K.R., Jung, K., Stephan, C., Fleshner, N.E. and Yousef, G.M.
Clinical Chemistry 59
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November 2013
Loss of epidermal Evi/Wls results in a phenotype resembling psoriasiform dermatitis.
Augustin, I., Gross, J., Baumann, D., Korn, C., Kerr, G., Grigoryan, T., Mauch, C., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Boutros, M.
Journal of Experimental Medicine 210
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26 August 2013
Wnt/β-catenin signalling induces MLL to create epigenetic changes in salivary gland tumours.
Wend, P., Fang, L., Zhu, Q., Schipper, J.H., Loddenkemper, C., Kosel, F., Brinkmann, V., Eckert, K., Hindersin, S., Holland, J.D., Lehr, S., Kahn, M., Ziebold, U. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
EMBO Journal 32
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17 July 2013
Wnt signaling in stem and cancer stem cells.
Holland, J.D., Klaus, A. ORCID: https://orcid.org/0000-0002-1164-3322, Garratt, A.N. ORCID: https://orcid.org/0000-0001-9631-3041 and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Current Opinion in Cell Biology 25
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April 2013
Sodium current deficit and arrhythmogenesis in a murine model of plakophilin-2 haploinsufficiency.
Cerrone, M., Noorman, M., Lin, X., Chkourko, H., Liang, F.X., van der Nagel, R., Hund, T., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Mohler, P., van Veen, T.A., van Rijen, H.V. and Delmar, M.
Cardiovascular Research 95
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1 September 2012
Specific paucity of unmyelinated C-fibers in cutaneous peripheral nerves of the African naked-mole rat: comparative analysis using six species of bathyergidae.
Smith, E.S.J. ORCID: https://orcid.org/0000-0002-2699-1979, Purfürst, B. ORCID: https://orcid.org/0000-0002-9887-7577, Grigoryan, T., Park, T.J., Bennett, N.C. and Lewin, G.R. ORCID: https://orcid.org/0000-0002-2890-6352
Journal of Comparative Neurology 520
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15 August 2012
Neocortical dendritic complexity is controlled during development by NOMA-GAP-dependent inhibition of Cdc42 and activation of cofilin.
Rosario, M., Schuster, S., Juettner, R. ORCID: https://orcid.org/0000-0003-3565-0698, Parthasarathy, S., Tarabykin, V. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Genes & Development 26
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1 August 2012
Wnt/beta-catenin and Bmp signals control distinct sets of transcription factors in cardiac progenitor cells.
Klaus, A. ORCID: https://orcid.org/0000-0002-1164-3322, Mueller, M., Schulz, H. ORCID: https://orcid.org/0000-0002-0226-964X, Saga, Y., Martin, J.F. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Proceedings of the National Academy of Sciences of the United States of America 109
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3 July 2012
The role of Irf6 in tooth epithelial invagination.
Blackburn, J., Ohazama, A., Kawasaki, K., Otsuka-Tanaka, Y., Liu, B., Honda, K., Rountree, R.B., Hu, Y., Kawasaki, M., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Schmidt-Ullrich, R. ORCID: https://orcid.org/0000-0002-2472-6530, Kinoshita, A., Schutte, B.C., Hammond, N.L., Dixon, M.J. and Sharpe, P.T.
Developmental Biology 365
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1 May 2012
The miRNA-kallikrein axis of interaction: a new dimension in the pathogenesis of prostate cancer.
White, N.M.A., Youssef, Y.M., Fendler, A. ORCID: https://orcid.org/0000-0002-7267-0981, Stephan, C., Jung, K. and Yousef, G.M.
Biological Chemistry 393
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May 2012
The tyrosine phosphatase Shp2 acts downstream of GDNF/Ret in branching morphogenesis of the developing mouse kidney.
Willecke, R., Heuberger, J. ORCID: https://orcid.org/0000-0001-7205-732X, Grossmann, K., Michos, O., Schmidt-Ott, K. ORCID: https://orcid.org/0000-0002-7700-7142, Walentin, K., Costantini, F. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Developmental Biology 360
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15 December 2011
BCL9-2 promotes early stages of intestinal tumor progression.
Brembeck, F.H., Wiese, M., Zatula, N., Grigoryan, T., Dai, Y., Fritzmann, J. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Gastroenterology 141
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October 2011
E-cadherin is crucial for embryonic stem cell pluripotency and can replace OCT4 during somatic cell reprogramming.
Redmer, T. ORCID: https://orcid.org/0000-0002-0050-9478, Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Grigoryan, T., Quiroga-Negreira, A., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Besser, D. ORCID: https://orcid.org/0000-0002-4958-9624
EMBO Reports 12
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1 July 2011
Epicatechin gallate and catechin gallate are superior to epigallocatechin gallate in growth suppression and anti-inflammatory activities in pancreatic tumor cells.
Kuerbitz, C., Heise, D., Redmer, T. ORCID: https://orcid.org/0000-0002-0050-9478, Goumas, F., Arlt, A., Lemke, J., Rimbach, G., Kalthoff, H. and Trauzold, A.
Cancer Science 102
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April 2011
Identification of Y-box binding protein 1 as a core regulator of MEK/ERK pathway-dependent gene signatures in colorectal cancer cells.
Juerchott, K., Kuban, R.J., Krech, T., Blüthgen, N. ORCID: https://orcid.org/0000-0002-0171-7447, Stein, U. ORCID: https://orcid.org/0000-0001-7006-282X, Walther, W. ORCID: https://orcid.org/0000-0003-2884-0231, Friese, C., Kielbasa, S.M., Ungethuem, U., Lund, P., Knoesel, T., Kemmner, W. ORCID: https://orcid.org/0000-0002-1494-7225, Morkel, M. ORCID: https://orcid.org/0000-0002-2553-9999, Fritzmann, J., Schlag, P.M., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Krueger, T., Sperling, S. ORCID: https://orcid.org/0000-0002-7135-3298, Sers, C., Royer, H.D., Herzel, H. and Schaefer, R.
PLoS Genetics 6
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2 December 2010
Bone morphogenetic protein-7 release from endogenous neural precursor cells suppresses the tumourigenicity of stem-like glioblastoma cells.
Chirasani, S.R., Sternjak, A., Wend, P., Momma, S., Campos, B., Herrmann, I.M., Graf, D., Mitsiadis, T., Herold-Mende, C., Besser, D. ORCID: https://orcid.org/0000-0002-4958-9624, Synowitz, M., Kettenmann, H. ORCID: https://orcid.org/0000-0001-8208-0291 and Glass, R.
Brain 133
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July 2010
Two isoforms of human RNA polymerase III with specific functions in cell growth and transformation.
Haurie, V., Durrieu-Gaillard, S., Dumay-Odelot, H., Da Silva, D., Rey, C., Prochazkova, M., Roeder, R.G., Besser, D. ORCID: https://orcid.org/0000-0002-4958-9624 and Teichmann, M.
Proceedings of the National Academy of Sciences of the United States of America 107
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2 March 2010
Interplay of cadherin-mediated cell adhesion and canonical wnt signaling.
Heuberger, J. ORCID: https://orcid.org/0000-0001-7205-732X and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Cold Spring Harbor Perspectives in Biology 2
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February 2010
Role of Epiprofin, a zinc-finger transcription factor, in limb development.
Talamillo, A., Delgado, I., Nakamura, T., de-Vega, S., Yoshitomi, Y., Unda, F., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Yamada, Y. and Ros, M.A.
Developmental Biology 337
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15 January 2010
The LIM domain protein Wtip interacts with the receptor tyrosine kinase Ror2 and inhibits canonical Wnt signalling.
Wijk, N.V., Witte, F., Feike, A.C., Schambony, A., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Mundlos, S. and Stricker, S.
Biochemical and Biophysical Research Communications 390
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11 December 2009
The tyrosine phosphatase Shp2 (PTPN11) directs neuregulin-1/ErbB signaling throughout schwann cell development.
Grossmann, K.S., Wende, H. ORCID: https://orcid.org/0000-0002-9168-8095, Paul, F.E. ORCID: https://orcid.org/0000-0001-5181-3122, Cheret, C. ORCID: https://orcid.org/0000-0001-7382-0403, Garratt, A.N. ORCID: https://orcid.org/0000-0001-9631-3041, Zurborg, S., Feinberg, K., Besser, D. ORCID: https://orcid.org/0000-0002-4958-9624, Schulz, H. ORCID: https://orcid.org/0000-0002-0226-964X, Peles, E., Selbach, M. ORCID: https://orcid.org/0000-0003-2454-8751, Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Birchmeier, C. ORCID: https://orcid.org/0000-0002-2041-8872
Proceedings of the National Academy of Sciences of the United States of America 106
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29 September 2009
Reciprocal requirements for EDA/EDAR/NF-κB and Wnt/β-catenin signaling pathways in hair follicle induction.
Zhang, Y., Tomann, P., Andl, T., Gallant, N.M., Huelsken, J., Jerchow, B., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Paus, R., Piccolo, S., Mikkola, M.L., Morrisey, E.E., Overbeek, P.A., Scheidereit, C. ORCID: https://orcid.org/0000-0002-0446-6129, Millar, S.E. and Schmidt-Ullrich, R. ORCID: https://orcid.org/0000-0002-2472-6530
Developmental Cell 17
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21 July 2009
A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential.
Fritzmann, J., Morkel, M. ORCID: https://orcid.org/0000-0002-2553-9999, Besser, D. ORCID: https://orcid.org/0000-0002-4958-9624, Budczies, J., Kosel, F., Brembeck, F.H., Stein, U. ORCID: https://orcid.org/0000-0001-7006-282X, Fichtner, I., Schlag, P.M. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Gastroenterology 137
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July 2009
Developmental signaling in myocardial progenitor cells: A comprehensive view of Bmp- and Wnt/beta-catenin signaling.
Klaus, A. ORCID: https://orcid.org/0000-0002-1164-3322 and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Pediatric Cardiology 30
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July 2009
Embryonic hair follicle fate change by augmented β-catenin through Shh and Bmp signaling.
Suzuki, K., Yamaguchi, Y., Villacorte, M., Mihara, K., Akiyama, M., Shimizu, H., Taketo, M.M., Nakagata, N., Tsukiyama, T., Yamaguchi, T.P., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Kato, S. and Yamada, G.
Development 136
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February 2009
MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis.
Stein, U. ORCID: https://orcid.org/0000-0001-7006-282X, Walther, W. ORCID: https://orcid.org/0000-0003-2884-0231, Arlt, F., Schwabe, H., Smith, J., Fichtner, I., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Schlag, P.M.
Nature Medicine 15
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January 2009
Homogeneity and persistence of transgene expression by omitting antibiotic selection in cell line isolation.
Kaufman, W.L., Kocman, I., Agrawal, V., Rahn, H.P. ORCID: https://orcid.org/0000-0002-5233-3937, Besser, D. ORCID: https://orcid.org/0000-0002-4958-9624 and Gossen, M. ORCID: https://orcid.org/0000-0002-1761-4063
Nucleic Acids Research 36
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October 2008
FGF2 signaling in mouse embryonic fibroblasts is crucial for self-renewal of embryonic stem cells.
Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Quiroga-Negreira, A., Redmer, T. ORCID: https://orcid.org/0000-0002-0050-9478 and Besser, D. ORCID: https://orcid.org/0000-0002-4958-9624
Cells Tissues Organs 188
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July 2008
Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking.
Hellmuth, K., Grosskopf, S., Lum, C.T., Wuertele, M., Roeder, N., von Kries, J.P. ORCID: https://orcid.org/0000-0003-4716-4988, Rosario, M., Rademann, J. ORCID: https://orcid.org/0000-0001-6678-3165 and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Proceedings of the National Academy of Sciences of the United States of America 105
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20 May 2008
Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling.
Malanchi, I., Peinado, H., Kassen, D., Hussenet, T., Metzger, D., Chambon, P., Huber, M., Hohl, D., Cano, A., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Huelsken, J.
Nature 452
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3 April 2008
Sustained epithelial beta-catenin activity induces precocious hair development but disrupts hair follicle down-growth and hair shaft formation.
Naerhi, K., Jaervinen, E., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Taketo, M.M., Mikkola, M.L. and Thesleff, I.
Development 135
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March 2008
Long-term, multilineage hematopoiesis occurs in the combined absence of beta-catenin and gamma-catenin.
Jeannet, G., Scheller, M. ORCID: https://orcid.org/0000-0001-6108-0831, Scarpellino, L., Duboux, S., Gardiol, N., Back, J., Kuttler, F., Malanchi, I., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Leutz, A. ORCID: https://orcid.org/0000-0001-8259-927X, Huelsken, J. and Held, W.
Blood 111
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1 January 2008
Distinct roles of Wnt/beta-catenin and Bmp signaling during early cardiogenesis.
Klaus, A. ORCID: https://orcid.org/0000-0002-1164-3322, Saga, Y., Taketo, M.M., Tzahor, E. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Proceedings of the National Academy of Sciences of the United States of America 104
(47): 18531-18536.
20 November 2007
Distinct requirements for Gab1 in Met and EGF receptor signaling in vivo.
Schaeper, U., Vogel, R., Chmielowiec, J., Huelsken, J., Rosario, M. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Proceedings of the National Academy of Sciences of the United States of America 104
(39): 15376-15381.
25 September 2007
The neurite outgrowth multiadaptor RhoGAP, NOMA-GAP, regulates neurite extension through SHP2 and Cdc42.
Rosario, M., Franke, R., Bednarski, C. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Journal of Cell Biology 178
(3): 503-516.
30 July 2007
Mutations of the Wnt antagonist AXIN2 (Conductin) result in TCF-dependent transcription in medulloblastomas.
Koch, A., Hrychyk, A., Hartmann, W., Waha, A., Mikeska, T., Waha, A., Schueller, U., Soerensen, N., Berthold, F., Goodyer, C.G., Wiestler, O.D., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Behrens, J. and Pietsch, T.
International Journal of Cancer 121
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15 July 2007
Beta-catenin downregulation is required for adaptive cardiac remodeling.
Baurand, A., Zelarayan, L. ORCID: https://orcid.org/0000-0002-9001-0346, Betney, R., Gehrke, C., Dunger, S., Noack, C., Busjahn, A., Huelsken, J., Taketo, M.M., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Dietz, R. and Bergmann, M.W.
Circulation Research 100
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11 May 2007
The transcriptional repressor Glis2 is a novel binding partner for p120 catenin.
Hosking, C.R., Ulloa, F., Hogan, C., Ferber, E., Figueroa, A., Gevaert, K., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Briscoe, J. and Fujita, Y.
Molecular Biology of the Cell 18
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1 May 2007
c-Met is essential for wound healing in the skin.
Chmielowiec, J., Borowiak, M. ORCID: https://orcid.org/0000-0002-5829-1213, Morkel, M. ORCID: https://orcid.org/0000-0002-2553-9999, Stradal, T., Munz, B., Werner, S., Wehland, J., Birchmeier, C. ORCID: https://orcid.org/0000-0002-2041-8872 and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Journal of Cell Biology 177
(1): 151-162.
9 April 2007
Beta-catenin regulates P-cadherin expression in mammary basal epithelial cells.
Faraldo, M.M., Teuliere, J., Deugnier, M.A., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Huelsken, J., Thiery, J.P., Cano, A. and Glukhova, M.A.
FEBS Letters 581
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6 March 2007
Bmp and Wnt/beta-catenin signals control expression of the transcription factor Olig3 and the specification of spinal cord neurons.
Zechner, D. ORCID: https://orcid.org/0000-0002-2075-7540, Muller, T. ORCID: https://orcid.org/0000-0001-8096-1853, Wende, H. ORCID: https://orcid.org/0000-0002-9168-8095, Walther, I., Taketo, M.M., Crenshaw, E.B., Treier, M. ORCID: https://orcid.org/0000-0002-8751-1246, Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Birchmeier, C. ORCID: https://orcid.org/0000-0002-2041-8872
Developmental Biology 303
(1): 181-190.
1 March 2007
Continuous tooth generation in mouse is induced by activated epithelial Wnt/β-catenin signaling.
Jaervinen, E., Salazar-Ciudad, I., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Taketo, M.M., Jernvall, J. and Thesleff, I.
Proceedings of the National Academy of Sciences of the United States of America 103
(49): 18627-18632.
5 December 2006
The metastasis-associated gene S100A4 is a novel target of beta-catenin/T-cell factor (TCF) signaling in colon cancer.
Stein, U. ORCID: https://orcid.org/0000-0001-7006-282X, Arlt, F., Walther, W. ORCID: https://orcid.org/0000-0003-2884-0231, Smith, J., Waldman, T., Harris, E.D., Mertins, S.D., Heizmann, C.W., Allard, D., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Schlag, P.M. and Shoemaker, R.H.
Gastroenterology 131
(5): 1486-1500.
November 2006
Diversin regulates heart formation and gastrulation movements in development.
Moeller, H., Jenny, A., Schaeffer, H.J. ORCID: https://orcid.org/0000-0003-2010-9153, Schwarz-Romond, T., Mlodzik, M., Hammerschmidt, M. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Proceedings of the National Academy of Sciences of the United States of America 103
(43): 15900-15905.
24 October 2006
Hematopoietic stem cell and multilineage defects generated by constitutive beta-catenin activation.
Scheller, M. ORCID: https://orcid.org/0000-0001-6108-0831, Huelsken, J., Rosenbauer, F. ORCID: https://orcid.org/0000-0001-7977-9421, Taketo, M.M., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Tenen, D.G. and Leutz, A. ORCID: https://orcid.org/0000-0001-8259-927X
Nature Immunology 7
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October 2006
Aberrant Wnt/beta-catenin signaling can induce chromosomal instability in colon cancer.
Hadjihannas, M.V., Brueckner, M., Jerchow, B., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Dietmaier, W. and Behrens, J.
Proceedings of the National Academy of Sciences of the United States of America 103
(28): 10747-10752.
11 July 2006
Multiple roles of mesenchymal beta-catenin during murine limb patterning.
Hill, T.P., Taketo, M.M., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Hartmann, C.
Development 133
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1 April 2006
Expression of multidrug resistance proteins (Mrps) in astrocytes of the mouse brain: a single cell rt-PCR study.
Hirrlinger, J., Moeller, H., Kirchhoff, F. ORCID: https://orcid.org/0000-0002-2324-2761 and Dringen, R.
Neurochemical Research 30
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1 October 2005
A human protein-protein interaction network: a resource for annotating the proteome.
Stelzl, U. ORCID: https://orcid.org/0000-0003-2500-3585, Worm, U., Lalowski, M., Haenig, C. ORCID: https://orcid.org/0000-0003-1973-7646, Brembeck, F.H., Goehler, H., Stroedicke, M., Zenkner, M., Schoenherr, A., Koeppen, S., Timm, J., Mintzlaff, S., Abraham, C., Bock, N., Kietzmann, S., Goedde, A., Toksoez, E., Droege, A., Krobitsch, S., Korn, B., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Lehrach, H. and Wanker, E.E. ORCID: https://orcid.org/0000-0001-8072-1630
Cell 122
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23 September 2005
The MEK1 scaffolding protein MP1 regulates cell spreading by integrating PAK1 and Rho signals.
Pullikuth, A., McKinnon, E., Schaeffer, H.J. ORCID: https://orcid.org/0000-0003-2010-9153 and Catling, A.D.
Molecular and Cellular Biology 25
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1 June 2005
Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes.
Hill, T.P., Spaeter, D., Taketo, M.M., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Hartmann, C.
Developmental Cell 8
(5): 727-738.
1 May 2005
MEK Partner 1 (MP1): Regulation of oligomerization in MAP kinase signaling.
Sharma, C., Vomastek, T., Tarcsafalvi, A., Catling, A.D., Schaeffer, H.J. ORCID: https://orcid.org/0000-0003-2010-9153, Eblen, S.T. and Weber, M.J.
Journal of Cellular Biochemistry 94
(4): 708-719.
1 January 2005
The role of Axin2 in calvarial morphogenesis and craniosynostosis.
Yu, H.M., Jerchow, B., Sheu, T.J., Liu, B., Costantini, F., Puzas, J.E., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Hsu, W.
Development 132
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1 January 2005
Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung.
Shu, W., Guttentag, S., Wang, Z., Andl, T., Ballard, P., Lu, M.M., Piccolo, S., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Whitsett, J.A., Millar, S.E. and Morrisey, E.E.
Developmental Biology 283
(1): 226-239.
1 January 2005
The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells.
Schuetz, G. ORCID: https://orcid.org/0000-0002-3523-0231, Rosario, M., Grimm, J., Boeckers, T.M., Gundelfinger, E.D. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Journal of Cell Biology 167
(5): 945-952.
6 December 2004
Mutations in the desmosomal protein plakophilin-2 are common in arrhythmogenic right ventricular cardiomyopathy.
Gerull, B. ORCID: https://orcid.org/0000-0002-1363-8826, Heuser, A. ORCID: https://orcid.org/0000-0002-3334-960X, Wichter, T., Paul, M., Basson, C.T., McDermott, D.A., Lerman, B.B., Markowitz, S.M., Ellinor, P.T., MacRae, C.A., Peters, S., Grossmann, K.S., Drenckhahn, J. ORCID: https://orcid.org/0000-0001-8347-7696, Michely, B., Sasse-Klaassen, S. ORCID: https://orcid.org/0000-0001-5925-9912, Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Dietz, R., Breithardt, G., Schulze-Bahr, E. and Thierfelder, L.
Nature Genetics 36
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November 2004
Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation.
Grossmann, K.S., Grund, C., Huelsken, J., Behrend, M., Erdmann, B., Franke, W.W. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Journal of Cell Biology 167
(1): 149-160.
11 October 2004
beta-catenin-dependent and -independent effects of deltaN-plakoglobin on epidermal growth and differentiation.
Teuliere, J., Faraldo, M.M., Shtutman, M., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Huelsken, J., Thiery, J.P. and Glukhova, M.A.
Molecular and Cellular Biology 24
(19): 8649-8661.
1 October 2004
Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions.
Brembeck, F.H., Schwarz-Romond, T., Bakkers, J., Wilhelm, S., Hammerschmidt, M. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Genes & Development 18
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15 September 2004
Expression of nodal, lefty-A, and lefty-B in undifferentiated human embryonic stem cells requires activation of Smad2/3.
Besser, D.
Journal of Biological Chemistry 279
(43): 45076-45084.
1 January 2004
Mutations and elevated transcriptional activity of conductin (AXIN2) in hepatoblastomas.
Koch, A., Weber, N., Waha, A., Hartmann, W., Denkhaus, D., Behrens, J., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, von Schweinitz, D. and Pietsch, T.
Journal of Pathology 204
(5): 546-554.
1 January 2004
Rap1 regulates the formation of E-cadherin-based cell-cell contacts.
Hogan, C., Serpente, N., Cogram, P., Hosking, C.R., Bialucha, C.U., Feller, S.M., Braga, V.M.M., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Fujita, Y.
Molecular and Cellular Biology 24
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1 January 2004
The docking protein Gab1 is an essential component of an indirect mechanism for fibroblast growth factor stimulation of the phosphatidylinositol 3-kinase/Akt antiapoptotic pathway.
Lamothe, B., Yamada, M., Schaeper, U., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Lax, I. and Schlessinger, J.
Molecular and Cellular Biology 24
(13): 5657-5666.
1 January 2004
Tyrosine kinase receptor RON functions downstream of the erythropoietin receptor to induce expansion of erythroid progenitors.
van den Akker, E., van Dijk, T., Parren-van Amelsvoort, M., Grossmann, K.S., Schaeper, U., Toney-Earley, K., Waltz, S.E., Loewenberg, B. and von Lindern, M.
Blood 103
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1 January 2004
Deciphering the function of signaling pathways by tissue specific gene modification in mice.
Zechner, D. ORCID: https://orcid.org/0000-0002-2075-7540, Soshnikova, N. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Zellbiologie Aktuell 30
(1): 6-8.
January 2004
Role of β-catenin in synaptic vesicle localization and presynaptic assembly.
Bamji, S.X., Shimazu, K., Kimes, N., Huelsken, J., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Lu, B. and Reichardt, L.F.
Neuron 40
(4): 719-731.
November 2003
β-catenin is required for specification of proximal/distal cell fate during lung morphogenesis.
Mucenski, M.L., Wert, S.E., Nation, J.M., Loudy, D.E., Huelsken, J., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Morrisey, E.E. and Whitsett, J.A.
Journal of Biological Chemistry 278
(41): 40231-40238.
10 October 2003
beta-catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system.
Zechner, D. ORCID: https://orcid.org/0000-0002-2075-7540, Fujita, Y., Huelsken, J., Mueller, T. ORCID: https://orcid.org/0000-0001-8096-1853, Walther, I., Taketo, M.M., Crenshaw, E.B., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Birchmeier, C. ORCID: https://orcid.org/0000-0002-2041-8872
Developmental Biology 258
(2): 406-418.
15 June 2003
Helicobacter pylori CagA protein targets the c-Met receptor and enhances the motogenic response.
Churin, Y., Al Ghoul, L., Kepp, O., Meyer, T.E., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Naumann, M.
Journal of Cell Biology 161
(2): 249-255.
28 April 2003
Deletion of beta-catenin impairs T cell development.
Xu, Y., Banerjee, D., Huelsken, J., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Sen, J.M.
Nature Immunology 4
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1 January 2003
Genetic interaction between Wnt/β-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb.
Soshnikova, N., Zechner, D. ORCID: https://orcid.org/0000-0002-2075-7540, Huelsken, J., Mishina, Y., Behringer, R.R., Taketo, M.M., Crenshaw, E.B. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Genes & Development 17
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1 January 2003
β-Catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation.
Morkel, M. ORCID: https://orcid.org/0000-0002-2553-9999, Huelsken, J., Wakamiya, M., Ding, J., van de Wetering, M., Clevers, H., Taketo, M.M., Behringer, R.R., Shen, M.M. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Development 130
(25): 6283-6294.
1 January 2003
The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling.
Schwarz-Romond, T., Asbrand, C., Bakkers, J., Kuehl, M., Schaeffer, H.J. ORCID: https://orcid.org/0000-0003-2010-9153, Huelsken, J., Behrens, J., Hammerschmidt, M. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Genes & Development 16
(16): 2073-2084.
15 August 2002
Selection of multipotent stem cells during morphogenesis of small intestinal crypts of Lieberkuehn is perturbed by stimulation of Lef-1/β-catenin signaling.
Wong, M.H., Huelsken, J., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Gordon, J.I.
Journal of Biological Chemistry 277
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3 May 2002
Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex.
Fujita, Y., Krause, G., Scheffner, M., Zechner, D. ORCID: https://orcid.org/0000-0002-2075-7540, Leddy, H.E.M., Behrens, J., Sommer, T. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Nature Cell Biology 4
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1 March 2002
Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors.
Lustig, B., Jerchow, B., Sachs, M., Weiler, S., Pietsch, T., Karsten, U., van de Wetering, M., Clevers, H., Schlag, P.M., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Behrens, J.
Molecular and Cellular Biology 22
(4): 1184-1193.
1 February 2002
Expression of deltaNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours.
Niemann, C., Owens, D.M., Huelsken, J., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Watt, F.M.
Development 129
: 95-109.
1 January 2002
The impact of c-met/scatter factor receptor on dendritic cell migration.
Kurz, S.M., Diebold, S.S., Hieronymus, T., Gust, T.C., Bartunek, P., Sachs, M., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Zenke, M.
European Journal of Immunology 32
(7): 1832-1838.
1 January 2002
Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation.
Grimm, J., Sachs, M., Britsch, S. ORCID: https://orcid.org/0000-0003-4379-3322, Di Cesare, S., Schwarz-Romond, T. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Journal of Cell Biology 154
(2): 345-354.
23 July 2001
beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin.
Huelsken, J., Vogel, R., Erdmann, B., Cotsarelis, G. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Cell 105
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18 May 2001
Negative regulation of Ros receptor tyrosine kinase signaling: An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1.
Keilhack, H., Mueller, M., Boehmer, S.A., Frank, C., Weidner, K.M., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Ligensa, T., Berndt, A., Kosmehl, H., Gunther, B., Mueller, T., Birchmeier, C. ORCID: https://orcid.org/0000-0002-2041-8872 and Boehmer, F.D.
Journal of Cell Biology 152
(2): 325-334.
22 January 2001
Deletions of AXIN1, a component of the WNT/wingless pathway, in sporadic medulloblastomas.
Dahmen, R.P., Koch, A., Denkhaus, D., Tonn, J.C., Soerensen, N., Berthold, F., Behrens, J., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Wiestler, O.D. and Pietsch, T.
Cancer Research 61
: 7039-7043.
1 January 2001
Requirement of NF-kappaB/Rel for the development of hair follicles and other epidermal appendices.
Schmidt-Ullrich, R., Aebischer, T., Huelsken, J., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Klemm, U. and Scheidereit, C. ORCID: https://orcid.org/0000-0002-0446-6129
Development 128
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1 January 2001
The C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motif.
Lewitzky, M., Kardinal, C., Gehring, N.H., Schmidt, E.K., Konkol, B., Eulitz, M., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Schaeper, U. and Feller, S.M.
Oncogene 20
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1 January 2001
Cytochrome P450-dependent renal arachidonic acid metabolism in desoxycorticosterone acetate-salt hypertensive mice.
Honeck, H., Gross, V., Erdmann, B., Kaergel, E., Neunaber, R., Milia, A.F., Schneider, W., Luft, F.C. ORCID: https://orcid.org/0000-0002-8635-1199 and Schunck, W.H. ORCID: https://orcid.org/0000-0001-7965-7731
Hypertension 36
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1 October 2000
E-cadherin and adenomatous polyposis coli mutations are synergistic in intestinal tumor initiation in mice.
Smits, R., Ruiz, P., Diaz-Cano, S., Luz, A., Jagmohan-Changur, S., Breukel, C., Birchmeier, C. ORCID: https://orcid.org/0000-0002-2041-8872, Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Fodde, R.
Gastroenterology 119
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1 October 2000
Essential role of Gab1 for signaling by the c-Met receptor in vivo.
Sachs, M., Brohmann, H., Zechner, D. ORCID: https://orcid.org/0000-0002-2075-7540, Mueller, T., Huelsken, J., Walther, I., Schaeper, U., Birchmeier, C. ORCID: https://orcid.org/0000-0002-2041-8872 and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Journal of Cell Biology 150
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18 September 2000
Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses.
Schaeper, U., Gehring, N.H., Fuchs, K.P., Sachs, M., Kempkes, B. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Journal of Cell Biology 149
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26 June 2000
Control of beta-catenin signaling in tumor development.
Behrens, J.
Annals of the New York Academy of Sciences 910
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June 2000
Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL.
Sakkab, D., Lewitzky, M., Posern, G., Schaeper, U., Sachs, M., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Feller, S.M.
Journal of Biological Chemistry 275
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14 April 2000
Requirement for beta-catenin in anterior-posterior axis formation in mice.
Huelsken, J., Vogel, R., Brinkmann, V., Erdmann, B., Birchmeier, C. ORCID: https://orcid.org/0000-0002-2041-8872 and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Journal of Cell Biology 148
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7 February 2000
Hepatocyte growth factor and neuregulin in mammary gland cell morphogenesis.
Niemann, C., Brinkmann, V. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Advances in Experimental Medicine and Biology 480
: 9-18.
1 January 2000
Hot spots in beta-catenin for interactions with LEF-1, conductin and APC.
von Kries, J.P. ORCID: https://orcid.org/0000-0003-4716-4988, Winbeck, G., Asbrand, C., Schwarz-Romond, T., Sochnikova, N., Dell'Oro, A., Behrens, J. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Nature Structural Biology 7
: 800-807.
1 January 2000
Differential cross-talk of estrogen and growth factor receptors in two human mammary tumor cell lines.
Lichtner, R.B., Parczyk, K., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Schneider, M.R.
Journal of Steroid Biochemistry and Molecular Biology 71
(5-6): 181-189.
31 December 1999
Tumour-associated E-cadherin mutations alter cellular morphology, decrease cellular adhesion and increase cellular motility.
Handschuh, G., Candidus, S., Luber, B., Reich, U., Schott, C., Oswald, S., Becke, H., Hutzler, P., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Hoefler, H. and Becker, K.F.
Oncogene 18
: 4301-4312.
29 July 1999
Plakoglobin is essential for myocardial compliance but dispensable for myofibril insertion into adherens junctions.
Isac, C.M., Ruiz, P., Pfitzmaier, B., Haase, H., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Morano, I. ORCID: https://orcid.org/0000-0001-7315-2222
Journal of Cellular Biochemistry 72
(1): 8-15.
1 January 1999
Immunohistological analysis of E-cadherin, alpha-, beta- and gamma-catenin expression in colorectal cancer: Implications for cell adhesion and signaling.
Ghadimi, B.M., Behrens, J., Hoffmann, I., Haensch, W., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Schlag, P.M.
European Journal of Cancer 35
(1): 60-65.
January 1999
Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta.
Behrens, J., Jerchow, B.A., Wuertele, M., Grimm, J., Asbrand, C., Wirtz, R., Kuehl, M., Wedlich, D. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Science 280
(5363): 596-599.
24 April 1998
The plakoglobin knock-out mouse: A paradigm for the molecular analysis of cardiac cell junction formation.
Ruiz, P. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Trends in Cardiovascular Medicine 8
(3): 97-101.
April 1998
Engineered mutants of HGF/SF with reduced binding to heparan sulphate proteoglycans, decreased clearance and enhanced activity in vivo.
Hartmann, G., Prospero, T., Brinkmann, V., Ozcelik, O., Winter, G., Hepple, J., Batley, S., Bladt, F., Sachs, M., Birchmeier, C. ORCID: https://orcid.org/0000-0002-2041-8872, Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Gherardi, E.
Current Biology 8
(3): 125-134.
29 January 1998
C-met activation is necessary but not sufficient for liver colonization by B16 murine melanoma cells.
Lin, S., Rusciano, D., Lorenzoni, P., Hartmann, G., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Giordano, S., Comoglio, P. and Burger, M.M.
Clinical and Experimental Metastasis 16
: 253-265.
1 January 1998
E-Cadherin in human brain tumours: loss of immunoreactivity in malignant meningiomas.
Schwechheimer, K., Zhou, L. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Virchows Archiv 432
: 163-167.
1 January 1998
The spread and uptake pattern of intracerebrally administered oligonucleotides in nerve and glial cell populations of the rat brain.
Sommer, W., Cui, X., Erdmann, B., Wiklund, L., Bricca, G., Heilig, M. and Fuxe, K.
Antisense and Nucleic Acid Drug Development 8
: 75-85.
1 January 1998
Functional involvement of CD44, a family of cell adhesion molecules, in immune responses, tumour progression and haematopoiesis.
Guenthert, U., Schwaerzler, C., Wittig, B., Laman, J., Ruiz, P., Stauder, R., Bloem, A., Smadja-Joffe, F., Zoeller, M. and Rolink, A.
Advances in Experimental Medicine and Biology 451
: 43-49.
1998
From totipotent embryonic stem cells to spontaneously contracting smooth muscle cells: a retinoic acid and db-cAMP in vitro differentiation model.
Drab, M., Haller, H., Bychkov, R., Erdmann, B., Lindschau, C. ORCID: https://orcid.org/0000-0003-1960-099X, Haase, H., Morano, I. ORCID: https://orcid.org/0000-0001-7315-2222, Luft, F.C. ORCID: https://orcid.org/0000-0002-8635-1199 and Wobus, A.M.
FASEB Journal 11
(11): 905-915.
September 1997
Analysis of the E-cadherin and P-cadherin promoters in murine keratinocyte cell lines from different stages of mouse skin carcinogenesis.
Faraldo, M.L.M., Rodrigo, I., Behrens, J., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Cano, A.
Molecular Carcinogenesis 20
: 33-47.
1 January 1997
Expression of E-cadherin and catenins in invasive mammary carcinomas.
Zschiesche, W., Schoenborn, I., Behrens, J., Herrenknecht, K., Hartveit, F., Lilleng, P. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Anticancer Research 17
: 561-567.
1 January 1997
Expression of E-cadherin/catenin complexes in breast cancer: correlation with favourable prognostic factors and survival.
Schoenborn, I., Zschiesche, W., Behrens, J., Herrenknecht, K. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
International Journal of Oncology 11
: 1327-1334.
1 January 1997
Hepatocyte growth factor/ scatter factor (HGF/SF) signals via the STAT3/APRF transcription factor in human hepatoma cells and hepatocytes.
Schaper, F., Siewert, E., Gomez-Lechon, M.J., Gatsios, P., Sachs, M., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Heinrich, P.C. and Castell, J.
FEBS Letters 405
: 99-103.
1 January 1997
Role of HGF/SF and c-Met in morphogenesis and metastasis of epithelial cells.
Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Brinkmann, V., Niemann, C., Meiners, S., Dicesare, S., Naundorf, H. and Sachs, M.
Ciba Foundation Symposia 212
: 230-240.
1 January 1997
Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis.
Weidner, K.M., Dicesare, S., Sachs, M., Brinkmann, V., Behrens, J. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Nature 384
(6605): 173-176.
14 November 1996
Effects of intracellular angiotensin II in vascular smooth muscle cells.
Haller, H., Lindschau, C. ORCID: https://orcid.org/0000-0003-1960-099X, Erdmann, B., Quass, P. and Luft, F.C. ORCID: https://orcid.org/0000-0002-8635-1199
Circulation Research 79
(4): 765-772.
1 October 1996
Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart.
Ruiz, P., Brinkmann, V., Ledermann, B., Behrend, M., Grund, C., Thalhammer, C., Vogel, F., Birchmeier, C. ORCID: https://orcid.org/0000-0002-2041-8872, Guenthert, U., Franke, W.W. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Journal of Cell Biology 135
(1): 215-225.
October 1996
Functional interaction of beta-catenin with the transcription factor LEF-1.
Behrens, J., von Kries, J.P. ORCID: https://orcid.org/0000-0003-4716-4988, Kuehl, M., Bruhn, L., Wedlich, D., Grosschedl, R. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Nature 382
(6592): 638-642.
15 August 1996
Motogenic and morphogenic activity of epithelial receptor tyrosine kinases.
Sachs, M., Weidner, K.M., Brinkmann, V., Walther, I., Obermeier, A., Ullrich, A. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Journal of Cell Biology 133
(5): 1095-1107.
3 June 1996
Expression of cytochrome P45011B1 mRNA in the brain of normal and hypertensive transgenic rats.
Erdmann, B., Gerst, H., Lippoldt, A., Buelow, H., Ganten, D., Fuxe, K. and Bernhardt, R.
Brain Research 733
: 73-82.
1 January 1996
Mechanisms identified in the transcriptional control of epithelial gene expression.
Hennig, G., Loewrick, O., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Behrens, J.
Journal of Biological Chemistry 271
: 595-602.
1 January 1996
Prognostic value of E-cadherin expression in 413 gastric carcinomas.
Gabbert, H.E., Mueller, W., Schneiders, A., Meier, S., Moll, R., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Hommel, G.
International Journal of Cancer 69
: 184-189.
1 January 1996
Subcellular localization of angiotensin II immunoreactivity in the rat cerebellar cortex.
Erdmann, B., Fuxe, K. and Ganten, D.
Hypertension 28
: 818-824.
1 January 1996
Hepatocyte growth factor/scatter factor induces a variety of tissue-specific morphogenic programs in epithelial cells.
Brinkmann, V., Foroutan, H., Sachs, M., Weidner, K.M. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Journal of Cell Biology 131
(6 Pt. 1): 1573-1586.
December 1995
V-src kinase shifts the cadherin-based cell adhesion from the strong to the weak state and beta-catenin is not required for the shift.
Takeda, H., Nagafuchi, A., Yonemura, S., Tsukita, S., Behrens, J., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Tsukita, S.
Journal of Cell Biology 131
(6 Pt. 2): 1839-1847.
December 1995
Sequential requirement of hepatocyte growth factor and neuregulin in the morphogenesis and differentiation of the mammary gland.
Yang, Y., Spitzer, E., Meyer, D., Sachs, M., Niemann, C., Hartmann, G., Weidner, K.M., Birchmeier, C. ORCID: https://orcid.org/0000-0002-2041-8872 and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Journal of Cell Biology 131
(1): 215-226.
October 1995
Adherens junction proteins in tumour progression.
Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Huelsken, J. and Behrens, J.
Cancer Surveys 24
: 129-140.
1 January 1995
Characterization of the scatter factor/hepatocyte growth factor gene promoter - positive and negative regulatory elements direct gene expression to mesenchymal cells.
Plaschke-Schluetter, A., Behrens, J., Gherardi, E. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Journal of Biological Chemistry 270
: 830-836.
1 January 1995
Clinical significance of e-cadherin as a prognostic marker in thyroid carcinomas.
Scheumman, G.F.W., Hoangvu, C., Cetin, Y., Gimm, O., Behrens, J., von Wasielewski, R., Georgii, A., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, von zur Muehlen, A., Dralle, H. and Brabant, G.
Journal of Clinical Endocrinology and Metabolism 80
(7): 2168-2172.
1 January 1995
E-cadherin as a tumor (invasion) suppressor gene.
Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
BioEssays 17
: 97-99.
1 January 1995
E-cadherin as an invasion suppressor.
Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Huelsken, J. and Behrens, J.
Ciba Foundation Symposia 189
: 124-136, discussion 136-41, 174-6.
1 January 1995
EGF and TGFalpha modulate structural and functional differentiation of the mammary gland from pregnant mice in vitro: Possible role of the arachidomic pathway.
Spitzer, E., Zschiesche, W., Binas, B., Grosse, R. and Erdmann, B.
Journal of Cellular Biochemistry 57
: 495-508.
1 January 1995
Human adrenal CYP11B1: localization by in situ-hybridization and functional expression in cell cultures.
Erdmann, B., Denner, K., Gerst, H., Lenz, D. and Bernhardt, R.
Endocrine Research 21
: 425-435.
1 January 1995
Mutation of juxtamembrane tyrosine residue 1001 suppresses loss-of-function mutations of the met receptor in epithelial cells.
Weidner, K.M., Sachs, M., Riethmacher, D. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Proceedings of the National Academy of Sciences of the United States of America 92
: 2597-2601.
1 January 1995
Progression of carcinoma cells is associated with alterations in chromatin structure and factor binding at the E-cadherin promoter in vivo.
Hennig, G., Behrens, J., Truss, M., Frisch, S., Reichmann, E. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Oncogene 11
: 475-484.
1 January 1995
Zone-specific localization of cytochrome P45011B1 in human adrenal tissue by PCR-derived riboprobes.
Erdmann, B., Gerst, H., Buelow, H., Lenz, D., Baehr, V. and Bernhardt, R.
Histochemistry and Cell Biology 104
: 301-307.
1 January 1995
E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton.
Huelsken, J., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Behrens, J.
Journal of Cell Biology 127
(6 Pt. 2): 2061-2069.
December 1994
Inverse relation of E-cadherin and autocrine motility factor receptor expression as a prognostic factor in patients with bladder carcinomas.
Otto, T., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Schmidt, U., Hinke, A., Schipper, J., Ruebben, H. and Raz, A.
Cancer Research 54
(12): 3120-3123.
15 June 1994
E-cadherin gene mutations in human gastric carcinoma cell lines.
Oda, T., Kanai, Y., Oyama, T., Yoshiura, K., Shimoyama, Y., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Sugimura, T. and Hirohashi, S.
Proceedings of the National Academy of Sciences of the United States of America 91
(5): 1858-1862.
1 March 1994
Differences of E-cadherin expression levels and patterns in primary and metastatic human lung cancer.
Boehm, M., Totzeck, B., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Wieland, I.
Clinical and Experimental Metastasis 12
: 55-62.
1 January 1994
Immunocytochemical localization of heterologously expressed adrenodoxin and its electron acceptor cytochrome P45011B1 in Escherichia coli.
Erdmann, B., Henning, M., Uhlmann, H., Beckert, V., Grunau, C. and Bernhardt, R.
European Journal of Cell Biology 65
: 220-228.
1 January 1994
Localization of mammary-derived growth inhibitor in capillary endothelial cells of the bovine mammary gland.
Breter, H. and Erdmann, B.
Cell and Tissue Research 277
: 457-464.
1 January 1994
Localization of the human beta-catenin gene (CTNNB1) to 3p21: A region implicated in tumor development.
Kraus, C., Liehr, T., Huelsken, J., Behrens, J., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Grzeschik, K.H. and Ballhausen, W.G.
Genomics 23
: 272-274.
1 January 1994
Mesenchymal-epithelial transitions.
Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Birchmeier, C. ORCID: https://orcid.org/0000-0002-2041-8872
BioEssays 16
: 305-307.
1 January 1994
The motility signal of scatter factor /hepatocyte growth factor mediated through the receptor tyrosine kinase Met requires intracellular action of Ras.
Hartmann, G., Weidner, K.M., Schwarz, H. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Journal of Biological Chemistry 269
: 21936-21939.
1 January 1994
Tumor-suppressor gene products in cell contacts: the cadherin-APC-armadillo connection.
Huelsken, J., Behrens, J. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Current Opinion in Cell Biology 6
: 711-716.
1 January 1994
Differential loss of E-Cadherin expression in infiltrating ductal and lobular breast carcinomas.
Moll, R., Mitze, M., Frixen, U.H. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
American Journal of Pathology 143
(6): 1731-1742.
1 December 1993
Deletion of the e-Cadherin gene in hepatitis-B virus-positive chinese hepatocellular carcinomas.
Slagle, B.L., Zhou, Y.Z., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Scorsone, K.A.
Hepatology 18
(4): 757-762.
1 October 1993
Molecular mechanisms leading to cell junction (cadherin) deficiency in invasive carcinomas.
Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Weidner, K.M., Huelsken, J. and Behrens, J.
Seminars in Cancer Biology 4
(4): 231-239.
1 August 1993
E-cadherin expression in primary and metastatic gastric cancer: down-regulation correlates with cellular dedifferentiation and glandular disintegration.
Mayer, B., Johnson, J.P., Leitl, F., Jauch, K.W., Heiss, M.M., Schildberg, F.W., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Funke, I.
Cancer Research 53
(7): 1690-1695.
1 April 1993
The Met receptor tyrosine kinase transduces motility, proliferation, andmorphogenic signals of scatter factor/ hepatocyte growth factor in epithelial cells.
Weidner, K.M., Sachs, M. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Journal of Cell Biology 121
(1): 145-154.
April 1993
Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/?catenin complex in cells transformed with a temperature-sensitive v-SRC gene.
Behrens, J., Vakaet, L., Friis, R., Winterhager, E., van Roy, F., Mareel, M.M. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Journal of Cell Biology 120
(3): 757-766.
February 1993
Irregular distribution of mammary-derived growth inhibitor in the bovine mammary epithelium.
Erdmann, B. and Breter, H.
Cell and Tissue Research 272
: 383-389.
1 January 1993
Molecular mechanisms leading to loss of differentiation and gain of invasiveness in epithelial cells.
Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Weidner, K.M. and Behrens, J.
Journal of Cell Science Suppl. 17
: 159-164.
1 January 1993
Properties and functions of scatter factor/hepatocyte growth factor and its receptor c-Met.
Weidner, K.M., Hartmann, G., Sachs, M. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
American Journal of Respiratory Cell and Molecular Biology 8
: 229-237.
1 January 1993
Suitability of different protein a-gold markers for immunogold- silver staining in paraffin sections.
Breter, H. and Erdmann, B.
Biotechnic and Histochemistry 68
: 206-210.
1 January 1993
Undercoat-constitutive proteins of cell-cell adherens junctions.
Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Japanese Journal of Cancer Research 84
: 1332-1333.
1 January 1993
Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor.
Naldini, L., Tamagnone, L., Vigna, E., Sachs, M., Hartmann, G., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Daikuhara, Y., Tsubouchi, H., Blasi, F. and Comoglio, P.M.
EMBO Journal 11
(13): 4825-4833.
1 December 1992
Hormonal induction of functional differentiation and mammary-derived growth inhibitor expression in cultured mouse mammary gland explants.
Binas, B., Spitzer, E., Zschiesche, W., Erdmann, B., Kurtz, A., Mueller, T., Niemann, C., Blenau, W. and Grosse, R.
In Vitro Cellular & Developmental Biology 28A
(9-10): 625-634.
September 1992
A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesis.
Hartmann, G., Naldini, L., Weidner, K.M., Sachs, M., Vigna, E., Comoglio, P.M. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Proceedings of the National Academy of Sciences of the United States of America 89
: 11574-11578.
1 January 1992
Cell adhesion in invasion and metastasis.
Behrens, J., Frixen, U., Schipper, J., Weidner, K.M. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Seminars in Cell Biology 3
: 169-178.
1 January 1992
Book Section
Limb development.
Soshnikova, N. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
In:
Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine ; Vol. 1.
Springer, Berlin [u.a.], 976-981.
ISBN 3-540-44244-8
2006
Tyrosine kinases.
Schaeper, U. and Grossmann, K.S.
In:
Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine ; Vol. 2.
Springer, Berlin [u.a.], 1951-1959.
ISBN 3-540-44244-8
2006
HGF/SF c-Met signaling in the epithelial-mesenchymal transition and migration of muscle progenitor cells.
Schaeper, U. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
In:
Cell Migration in Development and Disease.
Wiley-VCH, Weinheim, 191-204.
ISBN 3-527-30587-4
1 January 2005
10. Tyrosine kinase receptors as driving forces for growth, motility and differentiation of epithelial cells.
Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Birchmeier, C. ORCID: https://orcid.org/0000-0002-2041-8872, Brinkmann, V. and Niemann, C.
In:
Epithelial Morphogenesis in Development and Disease.
Cell Adhesion and Communication
.
Harwood Acad. Publ., Amsterdam [u.a.], 217-231.
1 January 1999
Introduction.
Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
In:
Guidebook to the Extracellular Matrix, Anchor, and Adhesion Proteins.
Oxford University Press, New York, 121-125.
1999
Epithelial-mesenchymal transitions in development and tumor progression.
Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Birchmeier, C. ORCID: https://orcid.org/0000-0002-2041-8872
In:
Epithelial-Mesenchymal Interactions in Cancer.
Birkhaeuser, Basel, 1-15.
1 January 1995
Surgical and multimodal approaches to liver metastases.
Schlag, P.M., Huenerbein, M. and Hohenberger, P.
In:
Attempts to Understand Metastasis Formation.
Springer, Berlin [u.a.], 241-256.
1 January 1995
Cell-cell adhesion in invasion and metastasis of carcinomas.
Behrens, J. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
In:
Mammary Tumorigenesis and Malignant Progression.
Kluwer Acad. Publ., Norwell, MA, 251-266.
1 January 1994
Molecular aspects of the loss of cell adhesion and gain of invasiveness in carcinomas.
Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
In:
Proceedings of the international symposium of the Princess Takamatsu Cancer Research Fund.
Princess Takamatsu Symposia ; 24
.
University of Tokyo Press, Tokyo, 214-232.
1 January 1994
Molecular characteristics of HGF-SF and its role in cell motility and invasion.
Weidner, K.M., Hartmann, G., Naldini, L., Comoglio, P.M., Sachs, M., Fonatsch, C., Rieder, H. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
In:
Hepatocyte Growth Factor (HGF-SF) and the C-Met Receptor.
Birkhaeuser, Basel, 311-328.
1 January 1993
Molecular aspects of the invasion of carcinoma cells.
Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Weidner, K.M. and Behrens, J.
In:
Metastasis : Basic Research and its Clinical Application.
Karger, Basel, 95-107.
1 January 1992
Book
Epithelial Morphogenesis in Development and Disease.
Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Birchmeier, C. ORCID: https://orcid.org/0000-0002-2041-8872
Cell Adhesion and Communication
.
Harwood Acad. Publ., Amsterdam [u.a.].
1 January 1999
Attempts to Understand Metastasis Formation I - III. Part 1: Metastasis-Related Molecules.
Guenthert, U. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Springer, Berlin [u.a.].
1 January 1996
Attempts to Understand Metastasis Formation I - III. Part 2: Regulatory Factors.
Guenthert, U. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Springer, Berlin [u.a.].
1 January 1996
Attempts to Understand Metastasis Formation I - III. Part 3: Therapeutic Approaches to Metastasis Treatment.
Guenthert, U., Schlag, P.M. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Springer, Berlin [u.a.].
1 January 1996
Thesis
Genetische Analyse von Conductin durch zielgerichtete Mutagenese in der Maus.
Jerchow, B.
UNSPECIFIED thesis, UNSPECIFIED.
6 May 2003
Patent
Shp-2 inhibitors, pharmaceutical compositions comprising them and their use for treating phosphatase-mediated diseases [Shp-2-Inhibitoren, Arzneimittel, die sie enthalten sowie deren Verwendung zur Behandlung von Phosphatasen-vermittelten Krankheiten].
Hellmuth, K. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
EP1728790 ; WO06128909.
6 December 2006
Mittel zur Therapie von menschlichen Erkrankungen, insbesondere fuer die Therapie von Tumoren wie Kolonkarzinomen und Melanomen oder zur Geweberegeneration und Foerderung des Haarwuchses [Agents for treating human diseases, especially for treating tumors such as colonic cancers and melanomas or for regenerating tissue and promoting hair growth].
Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Kries, J.P.
DE19944404A1 ; EP1214345 ; WO0119353.
22 March 2001
Conductinprotein und verwandtes Mittel zur Diagnose und zur Therapie von Tumorerkrankungen [Conductine protein and a related agent for diagnosing and treating tumor illnesses].
Behrens, J. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
EP1029047 ; WO9911780.
28 September 2000
HGF polypeptides and their use in therapy [HGF Polypeptide und deren therapeutische Verwendungen].
Gherardi, E., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Hartmann, G.
EP0981620 ; DE69821930T2.
6 April 2000
Mittel zur Therapie von menschlichen Erkrankungen, ausgehend von b-Catenin, seine Herstellung und seine Verwendung.
Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Kries, J.P.
DE19909251A1 ; EP1054899 ; US7,067,474.
26 August 1999
Mittel zur Diagnose und zur Therapie von Tumorerkrankungen.
Behrens, J. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
DE19840875A1.
12 May 1999
Mittel zur Beeinflussung der Zelldifferenzierung und seine Verwendung.
Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
DE19509792A1.
19 September 1996
Verfahren zum Nachweis der Differenzierung und der Invasivitaet von Karzinomzellen.
Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Frixen, U. and Behrens, J.
DE4110405A1 ; EP0582582A1 ; EP0582582B1.
1 October 1992
Review
SHP-2 in lymphocytes' cytokine and inhibitory receptor signaling.
Niogret, C., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Guarda, G.
Frontiers in Immunology 10
: 2468.
25 October 2019
Circular RNAs: a new class of biomarkers as a rising interest in laboratory medicine.
Franz, A., Rabien, A., Stephan, C., Ralla, B., Fuchs, S., Jung, K. and Fendler, A. ORCID: https://orcid.org/0000-0002-7267-0981
Clinical Chemistry and Laboratory Medicine 56
(12): 1992-2003.
December 2018
The translational potential of microRNAs as biofluid markers of urological tumours.
Fendler, A. ORCID: https://orcid.org/0000-0002-7267-0981, Stephan, C., Yousef, G.M., Kristiansen, G. and Jung, K.
Nature Reviews Urology 13
(12): 734-752.
December 2016
Molecular signaling mechanisms of axon-glia communication in the peripheral nervous system.
Grigoryan, T. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
BioEssays 37
(5): 502-513.
May 2015
Targeting MET in cancer: rationale and progress.
Gherardi, E., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Birchmeier, C. ORCID: https://orcid.org/0000-0002-2041-8872 and Woude, G.V.
Nature Reviews Cancer 12
(2): 89-103.
February 2012
Wnt signaling in stem and cancer stem cells.
Wend, P., Holland, J.D., Ziebold, U. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Seminars in Cell & Developmental Biology 21
(8): 855-863.
October 2010
The tyrosine phosphatase Shp2 in development and cancer.
Grossmann, K.S., Rosario, M., Birchmeier, C. ORCID: https://orcid.org/0000-0002-2041-8872 and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Advances in Cancer Research 106
: 53-89.
2010
Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice.
Grigoryan, T., Wend, P., Klaus, A. ORCID: https://orcid.org/0000-0002-1164-3322 and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Genes & Development 22
(17): 2308-2341.
1 September 2008
Wnt signalling and its impact on development and cancer.
Klaus, A. ORCID: https://orcid.org/0000-0002-1164-3322 and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Nature Reviews Cancer 8
(5): 387-398.
May 2008
Balancing cell adhesion and Wnt signaling, the key role of beta-catenin.
Brembeck, F.H., Rosario, M. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Current Opinion in Genetics & Development 16
(1): 51-59.
February 2006
Met, metastasis, motility and more.
Birchmeier, C. ORCID: https://orcid.org/0000-0002-2041-8872, Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Gherardi, E. and Vande Woude, G.F.
Nature Reviews Molecular Cell Biology 4
(12): 915-925.
December 2003
How to make tubes: signaling by the Met receptor tyrosine kinase.
Rosario, M. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Trends in Cell Biology 13
(6): 328-335.
June 2003
New aspects of Wnt signaling pathways in higher vertebrates.
Huelsken, J. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Current Opinion in Genetics & Development 11
(5): 547-553.
1 October 2001
Reconstitution of mammary gland development in vitro: Requirement of c-met and c-erbB2 signaling for branching and alveolar morphogenesis.
Niemann, C., Brinkmann, V., Spitzer, E., Hartmann, G., Sachs, M., Naundorf, H. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Journal of Cell Biology 143
(2): 533-545.
19 October 1998
Role of morphogenetic factors in metastasis of mammary carcinoma cells.
Meiners, S., Brinkmann, V., Naundorf, H. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Oncogene 16
: 9-20.
1 January 1998
Epithelial differentiation and the control of metastasis in carcinomas.
Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Behrens, J., Weidner, K.M., Huelsken, J. and Birchmeier, C. ORCID: https://orcid.org/0000-0002-2041-8872
Current Topics in Microbiology and Immunology
: 117-135.
1 January 1996
Epithelial-mesenchymal transitions in cancer progression.
Birchmeier, C. ORCID: https://orcid.org/0000-0002-2041-8872, Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Brand-Saberi, B.
Acta Anatomica 156
: 217-226.
1 January 1996
Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness.
Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Behrens, J.
Biochimica et Biophysica Acta 1198
(1): 11-26.
27 May 1994
Molecular aspects of mesenchymal-epithelial interactions.
Birchmeier, C. ORCID: https://orcid.org/0000-0002-2041-8872 and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Annual Review of Cell Biology 9
: 511-540.
1993
Editorial
UroFors: Konstituierung eines Interessensverbundes fuer Naturwissenschaftler in der urologischen Forschung [UroFors: establishment of an interest group for natural scientists in urological research].
Stope, M.B., Dansranjavin, T., Erb, H., Erdmann, K., Fendler, A. ORCID: https://orcid.org/0000-0002-7267-0981, Hoelters, S., Juengel, E., Nitschke, K., Salomo, K., Seidel, P., Skowron, M.A., Wach, S. and Becker, C.
Urologe 56
(4): 515-518.
April 2017
Orchestrating Wnt signalling for metabolic liver zonation.
Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Nature Cell Biology 18
(5): 463-465.
May 2016
Where do you come from; where do you go? Pluripotency, differentiation and malfunction of stem cells.
Spagnoli, F.M. ORCID: https://orcid.org/0000-0001-7094-8188, Besser, D. ORCID: https://orcid.org/0000-0002-4958-9624 and Benitah, S.A.
EMBO Reports 13
(1): 9-11.
January 2012
Stem cells: Orphan receptors find a home.
Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Nature 476
(7360): 287-288.
18 August 2011
Arrhythmogenic right ventricular cardiomyopathy: moving toward mechanism.
MacRae, C.A., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Thierfelder, L.
Journal of Clinical Investigation 116
(7): 1825-1828.
July 2006
Cell adhesion and signal transduction in cancer.
Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
EMBO Reports 6
(5): 413-417.
1 January 2005
Making tubes: Step by step.
Rosario, M. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Developmental Cell 7
(1): 3-5.
1 July 2004
Hot papers in cell biology - J. Behrens, J.P. von Kries, M. Kuehl, L. Bruhn, D. Wedlich, R. Grosschedl, W. Birchmeier: "Functional interaction of beta-catenin with the transcription factor LEF-1" - Comments by Walter Birchmeier.
Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Scientist 13(8)
: 15.
12 April 1999
Preprint
Spatiotemporal dynamics of tumor microenvironment remodeling.
Lisek, Kamil ORCID: https://orcid.org/0000-0002-2406-8830, Theurillat, Ilan ORCID: https://orcid.org/0000-0002-1125-1951, Pentimalli, Tancredi Massimo ORCID: https://orcid.org/0000-0002-8461-7918, Beier, Svea ORCID: https://orcid.org/0009-0006-6473-8487, León-Periñán, Daniel ORCID: https://orcid.org/0000-0002-7970-0362, Antonatou, Anna, Dubnov, Serafima, Müller, Marion, Hubl, Florian, Xhuri, Artemis, Romanowicz, Hanna, Smolarz, Beata, Montaudon, Elodie, Raimundo, Sandra ORCID: https://orcid.org/0009-0000-3353-5456, Margineanu, Anca ORCID: https://orcid.org/0000-0002-6634-9729, Schott, Marie ORCID: https://orcid.org/0009-0000-7393-2421, Kunz, Séverine ORCID: https://orcid.org/0000-0002-0131-3506, Marangoni, Elisabetta, Karaiskos, Nikos ORCID: https://orcid.org/0000-0001-7771-3947, Nitzan, Mor, Birchmeier, Walter ORCID: https://orcid.org/0000-0003-1173-0829 and Rajewsky, Nikolaus ORCID: https://orcid.org/0000-0002-4785-4332
bioRxiv
: 2025.07.15.662972.
18 July 2025
Spatiotemporal dynamics of tumor microenvironment remodeling.
Lisek, Kamil ORCID: https://orcid.org/0000-0002-2406-8830, Theurillat, Ilan ORCID: https://orcid.org/0000-0002-1125-1951, Pentimalli, Tancredi Massimo ORCID: https://orcid.org/0000-0002-8461-7918, Beier, Svea ORCID: https://orcid.org/0009-0006-6473-8487, León-Periñán, Daniel ORCID: https://orcid.org/0000-0002-7970-0362, Antonatou, Anna, Dubnov, Serafima, Müller, Marion, Hubl, Florian, Xhuri, Artemis, Romanowicz, Hanna, Smolarz, Beata, Montaudon, Elodie, Raimundo, Sandra ORCID: https://orcid.org/0009-0000-3353-5456, Margineanu, Anca ORCID: https://orcid.org/0000-0002-6634-9729, Schott, Marie ORCID: https://orcid.org/0009-0000-7393-2421, Kunz, Séverine ORCID: https://orcid.org/0000-0002-0131-3506, Marangoni, Elisabetta, Karaiskos, Nikos ORCID: https://orcid.org/0000-0001-7771-3947, Nitzan, Mor, Birchmeier, Walter ORCID: https://orcid.org/0000-0003-1173-0829 and Rajewsky, Nikolaus ORCID: https://orcid.org/0000-0002-4785-4332
bioRxiv
: 2025.07.15.662972.
18 July 2025
Establishment of kidney cancer organoid cultures.
Bauer, D. ORCID: https://orcid.org/0000-0002-2933-4333, Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Fendler, A. ORCID: https://orcid.org/0000-0002-7267-0981
Research Square
: rs.3.pex-911.
12 May 2020
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