Browse by Research Team

Acta Anatomica

Epithelial-mesenchymal transitions in cancer progression.
Birchmeier, C., Birchmeier, W. and Brand-Saberi, B.
Acta Anatomica 156 : 217-226. 1 January 1996

Acta Pharmacologica Sinica

KLF4 functions as an oncogene in promoting cancer stem cell-like characteristics in osteosarcoma cells.
Qi, X.T., Li, Y.L., Zhang, Y.Q., Xu, T., Lu, B., Fang, L., Gao, J.Q., Yu, L.S., Zhu, D.F., Yang, B., He, Q.J. and Ying, M.D.
Acta Pharmacologica Sinica 40 (4): 546-555. April 2019

Advances in Cancer Research

The tyrosine phosphatase Shp2 in development and cancer.
Grossmann, K.S., Rosario, M., Birchmeier, C. and Birchmeier, W.
Advances in Cancer Research 106 : 53-89. 2010

Advances in Experimental Medicine and Biology

Hepatocyte growth factor and neuregulin in mammary gland cell morphogenesis.
Niemann, C., Brinkmann, V. and Birchmeier, W.
Advances in Experimental Medicine and Biology 480 : 9-18. 1 January 2000

Functional involvement of CD44, a family of cell adhesion molecules, in immune responses, tumour progression and haematopoiesis.
Guenthert, U., Schwaerzler, C., Wittig, B., Laman, J., Ruiz, P., Stauder, R., Bloem, A., Smadja-Joffe, F., Zoeller, M. and Rolink, A.
Advances in Experimental Medicine and Biology 451 : 43-49. 1998

American Journal of Pathology

Differential loss of E-Cadherin expression in infiltrating ductal and lobular breast carcinomas.
Moll, R., Mitze, M., Frixen, U.H. and Birchmeier, W.
American Journal of Pathology 143 (6): 1731-1742. 1 December 1993

American Journal of Respiratory Cell and Molecular Biology

Properties and functions of scatter factor/hepatocyte growth factor and its receptor c-Met.
Weidner, K.M., Hartmann, G., Sachs, M. and Birchmeier, W.
American Journal of Respiratory Cell and Molecular Biology 8 : 229-237. 1 January 1993

Annals of the New York Academy of Sciences

Control of beta-catenin signaling in tumor development.
Behrens, J.
Annals of the New York Academy of Sciences 910 : 21-35. June 2000

Annual Review of Cell Biology

Molecular aspects of mesenchymal-epithelial interactions.
Birchmeier, C. and Birchmeier, W.
Annual Review of Cell Biology 9 : 511-540. 1993

Anticancer Research

Expression of E-cadherin and catenins in invasive mammary carcinomas.
Zschiesche, W., Schoenborn, I., Behrens, J., Herrenknecht, K., Hartveit, F., Lilleng, P. and Birchmeier, W.
Anticancer Research 17 : 561-567. 1 January 1997

Antisense and Nucleic Acid Drug Development

The spread and uptake pattern of intracerebrally administered oligonucleotides in nerve and glial cell populations of the rat brain.
Sommer, W., Cui, X., Erdmann, B., Wiklund, L., Bricca, G., Heilig, M. and Fuxe, K.
Antisense and Nucleic Acid Drug Development 8 : 75-85. 1 January 1998

BioEssays

Molecular signaling mechanisms of axon-glia communication in the peripheral nervous system.
Grigoryan, T. and Birchmeier, W.
BioEssays 37 (5): 502-513. May 2015

E-cadherin as a tumor (invasion) suppressor gene.
Birchmeier, W.
BioEssays 17 : 97-99. 1 January 1995

Mesenchymal-epithelial transitions.
Birchmeier, W. and Birchmeier, C.
BioEssays 16 : 305-307. 1 January 1994

Biochemical and Biophysical Research Communications

The LIM domain protein Wtip interacts with the receptor tyrosine kinase Ror2 and inhibits canonical Wnt signalling.
Wijk, N.V., Witte, F., Feike, A.C., Schambony, A., Birchmeier, W., Mundlos, S. and Stricker, S.
Biochemical and Biophysical Research Communications 390 (2): 211-216. 11 December 2009

Biochimica et Biophysica Acta

Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness.
Birchmeier, W. and Behrens, J.
Biochimica et Biophysica Acta 1198 (1): 11-26. 27 May 1994

Biological Chemistry

The miRNA-kallikrein axis of interaction: a new dimension in the pathogenesis of prostate cancer.
White, N.M.A., Youssef, Y.M., Fendler, A., Stephan, C., Jung, K. and Yousef, G.M.
Biological Chemistry 393 (5): 379-389. May 2012

Biotechnic and Histochemistry

Suitability of different protein a-gold markers for immunogold- silver staining in paraffin sections.
Breter, H. and Erdmann, B.
Biotechnic and Histochemistry 68 : 206-210. 1 January 1993

Blood

Long-term, multilineage hematopoiesis occurs in the combined absence of beta-catenin and gamma-catenin.
Jeannet, G., Scheller, M., Scarpellino, L., Duboux, S., Gardiol, N., Back, J., Kuttler, F., Malanchi, I., Birchmeier, W., Leutz, A., Huelsken, J. and Held, W.
Blood 111 (1): 142-149. 1 January 2008

Tyrosine kinase receptor RON functions downstream of the erythropoietin receptor to induce expansion of erythroid progenitors.
van den Akker, E., van Dijk, T., Parren-van Amelsvoort, M., Grossmann, K.S., Schaeper, U., Toney-Earley, K., Waltz, S.E., Loewenberg, B. and von Lindern, M.
Blood 103 (12): 4457-4465. 1 January 2004

Brain

Decreased microglial Wnt/β-catenin signalling drives microglial pro-inflammatory activation in the developing brain.
Van Steenwinckel, J., Schang, A.L., Krishnan, M.L., Degos, V., Delahaye-Duriez, A., Bokobza, C., Csaba, Z., Verdonk, F., Montané, A., Sigaut, S., Hennebert, O., Lebon, S., Schwendimann, L., Le Charpentier, T., Hassan-Abdi, R., Ball, G., Aljabar, P., Saxena, A., Holloway, R.K., Birchmeier, W., Baud, O., Rowitch, D., Miron, V., Chretien, F., Leconte, C., Besson, V.C., Petretto, E.G., Edwards, A.D., Hagberg, H., Soussi-Yanicostas, N., Fleiss, B. and Gressens, P.
Brain 142 (12): 3806-3833. December 2019

Bone morphogenetic protein-7 release from endogenous neural precursor cells suppresses the tumourigenicity of stem-like glioblastoma cells.
Chirasani, S.R., Sternjak, A., Wend, P., Momma, S., Campos, B., Herrmann, I.M., Graf, D., Mitsiadis, T., Herold-Mende, C., Besser, D., Synowitz, M., Kettenmann, H. and Glass, R.
Brain 133 (Pt 7): 1961-1972. July 2010

Brain Research

Expression of cytochrome P45011B1 mRNA in the brain of normal and hypertensive transgenic rats.
Erdmann, B., Gerst, H., Lippoldt, A., Buelow, H., Ganten, D., Fuxe, K. and Bernhardt, R.
Brain Research 733 : 73-82. 1 January 1996

Breast Cancer Research

Targeting SHP2 phosphatase in breast cancer overcomes RTK-mediated resistance to PI3K inhibitors.
Heynen, G.J.J.E., Lisek, K., Vogel, R., Wulf-Goldenberg, A., Alcaniz, J., Montaudon, E., Marangoni, E. and Birchmeier, W.
Breast Cancer Research 24 (1): 23. 1 April 2022

Cancer Biomarkers

The discriminative ability of Prostate Health Index to detect prostate cancer is enhanced in combination with miR-222-3p.
Tölle, A., Jung, K., Friedersdorff, F., Maxeiner, A., Lein, M., Fendler, A. and Stephan, C.
Cancer Biomarkers 30 (4): 381-393. 9 April 2021

Cancer Research

YAP and β-catenin cooperate to drive oncogenesis in basal breast cancer.
Quinn, H.M., Vogel, R., Popp, O., Mertins, P., Lan, L., Messerschmidt, C., Landshammer, A., Lisek, K., Château-Joubert, S., Marangoni, E., Koren, E., Fuchs, Y. and Birchmeier, W.
Cancer Research 81 (8): 2116-2127. April 2021

Cancer stem cells regulate cancer-associated fibroblasts via activation of Hedgehog signaling in mammary gland tumors.
Valenti, G., Quinn, H.M., Heynen, G.J.J.E., Lan, L., Holland, J.D., Vogel, R., Wulf-Goldenberg, A. and Birchmeier, W.
Cancer Research 77 (8): 2134-2147. 15 April 2017

A small-molecule antagonist of the β-catenin/TCF4 interaction blocks the self-renewal of cancer stem cells and suppresses tumorigenesis.
Fang, L., Zhu, Q., Neuenschwander, M., Specker, E., Wulf-Goldenberg, A., Weis, W.I., von Kries, J.P. and Birchmeier, W.
Cancer Research 76 (4): 891-901. 15 February 2016

Deletions of AXIN1, a component of the WNT/wingless pathway, in sporadic medulloblastomas.
Dahmen, R.P., Koch, A., Denkhaus, D., Tonn, J.C., Soerensen, N., Berthold, F., Behrens, J., Birchmeier, W., Wiestler, O.D. and Pietsch, T.
Cancer Research 61 : 7039-7043. 1 January 2001

Inverse relation of E-cadherin and autocrine motility factor receptor expression as a prognostic factor in patients with bladder carcinomas.
Otto, T., Birchmeier, W., Schmidt, U., Hinke, A., Schipper, J., Ruebben, H. and Raz, A.
Cancer Research 54 (12): 3120-3123. 15 June 1994

E-cadherin expression in primary and metastatic gastric cancer: down-regulation correlates with cellular dedifferentiation and glandular disintegration.
Mayer, B., Johnson, J.P., Leitl, F., Jauch, K.W., Heiss, M.M., Schildberg, F.W., Birchmeier, W. and Funke, I.
Cancer Research 53 (7): 1690-1695. 1 April 1993

Cancer Science

Epicatechin gallate and catechin gallate are superior to epigallocatechin gallate in growth suppression and anti-inflammatory activities in pancreatic tumor cells.
Kuerbitz, C., Heise, D., Redmer, T., Goumas, F., Arlt, A., Lemke, J., Rimbach, G., Kalthoff, H. and Trauzold, A.
Cancer Science 102 (4): 728-734. April 2011

Cancer Surveys

Adherens junction proteins in tumour progression.
Birchmeier, W., Huelsken, J. and Behrens, J.
Cancer Surveys 24 : 129-140. 1 January 1995

Cancers

Targeting Wnt/β-catenin signaling by TET1/FOXO4 inhibits metastatic spreading and self-renewal of cancer stem cells in gastric cancer.
Qi, J., Cui, D., Wu, Q.N., Zhao, Q., Chen, Z.H., Li, L., Birchmeier, W., Yu, Y. and Tao, R.
Cancers 14 (13): 3232. 30 June 2022

A novel predictor tool of biochemical recurrence after radical prostatectomy based on a five-microRNA tissue signature.
Zhao, Z., Weickmann, S., Jung, M., Lein, M., Kilic, E., Stephan, C., Erbersdobler, A., Fendler, A. and Jung, K.
Cancers 11 (10): 1603. 21 October 2019

Circular RNAs in clear cell renal cell carcinoma: their microarray-based identification, analytical validation, and potential use in a clinico-genomic model to improve prognostic accuracy.
Franz, A., Ralla, B., Weickmann, S., Jung, M., Rochow, H., Stephan, C., Erbersdobler, A., Kilic, E., Fendler, A. and Jung, K.
Cancers 11 (10): 1473. 30 September 2019

miR-9-5p in nephrectomy specimens is a potential predictor of primary resistance to first-line treatment with tyrosine kinase inhibitors in patients with metastatic renal cell carcinoma.
Ralla, B., Busch, J., Flörcken, A., Westermann, J., Zhao, Z., Kilic, E., Weickmann, S., Jung, M., Fendler, A. and Jung, K.
Cancers 10 (9): 321. 10 September 2018

Cardiovascular Research

Sodium current deficit and arrhythmogenesis in a murine model of plakophilin-2 haploinsufficiency.
Cerrone, M., Noorman, M., Lin, X., Chkourko, H., Liang, F.X., van der Nagel, R., Hund, T., Birchmeier, W., Mohler, P., van Veen, T.A., van Rijen, H.V. and Delmar, M.
Cardiovascular Research 95 (4): 460-468. 1 September 2012

Cell

A human protein-protein interaction network: a resource for annotating the proteome.
Stelzl, U., Worm, U., Lalowski, M., Haenig, C., Brembeck, F.H., Goehler, H., Stroedicke, M., Zenkner, M., Schoenherr, A., Koeppen, S., Timm, J., Mintzlaff, S., Abraham, C., Bock, N., Kietzmann, S., Goedde, A., Toksoez, E., Droege, A., Krobitsch, S., Korn, B., Birchmeier, W., Lehrach, H. and Wanker, E.E.
Cell 122 (6): 957-968. 23 September 2005

beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin.
Huelsken, J., Vogel, R., Erdmann, B., Cotsarelis, G. and Birchmeier, W.
Cell 105 (4): 533-545. 18 May 2001

Cell Death & Disease

Lenalidomide regulates CNS autoimmunity by promoting M2 macrophages polarization.
Weng, Q., Wang, J., Wang, J., Wang, J., Sattar, F., Zhang, Z., Zheng, J., Xu, Z., Zhao, M., Liu, X., Yang, L., Hao, G., Fang, L., Lu, Q.R., Yang, B. and He, Q.
Cell Death & Disease 9 (2): 251. 14 February 2018

Cell Reports

The Wnt-driven Mll1 epigenome regulates salivary gland and head and neck cancer.
Zhu, Q., Fang, L., Heuberger, J., Kranz, A., Schipper, J., Scheckenbach, K., Oliveira Vidal, R., Sunaga-Franze, D.Y., Müller, M., Wulf-Goldenberg, A., Sauer, S. and Birchmeier, W.
Cell Reports 26 (2): 415-428. 8 January 2019

Shp-2 is dispensable for establishing T cell exhaustion and for PD-1 signaling in vivo.
Rota, G., Niogret, C., Dang, A.T., Barros, C.R., Fonta, N.P., Alfei, F., Morgado, L., Zehn, D., Birchmeier, W., Vivier, E. and Guarda, G.
Cell Reports 23 (1): 39-49. 3 April 2018

RNF4-dependent oncogene activation by protein stabilization.
Thomas, J.J., Abed, M., Heuberger, J., Novak, R., Zohar, Y., Beltra-Lopez, A.P., Trausch-Azar, J.S., Ilagan, M.X.G., Benhamou, D., Dittmar, G., Kopan, R., Birchmeier, W., Schwartz, A.L. and Orian, A.
Cell Reports 16 (12): 3388-3400. 20 September 2016

Gab1 and Mapk signaling are essential in the hair cycle and hair follicle stem cell quiescence.
Akilli Öztürk, Ö., Pakula, H., Chmielowiec, J., Qi, J., Stein, S., Lan, L., Sasaki, Y., Rajewsky, K. and Birchmeier, W.
Cell Reports 13 (3): 561-572. 20 October 2015

Combined Wnt/β-catenin, met, and CXCL12/CXCR4 signals characterize basal breast cancer and predict disease outcome.
Holland, J.D., Györffy, B., Vogel, R., Eckert, K., Valenti, G., Fang, L., Lohneis, P., Elezkurtaj, S., Ziebold, U. and Birchmeier, W.
Cell Reports 5 (5): 1214-1227. 12 December 2013

Cell Stem Cell

Spatially restricted stromal Wnt signaling restrains prostate epithelial progenitor growth through direct and indirect mechanisms.
Wei, X., Zhang, L., Zhou, Z., Kwon, O.J., Zhang, Y., Nguyen, H., Dumpit, R., True, L., Nelson, P., Dong, B., Xue, W., Birchmeier, W., Taketo, M.M., Xu, F., Creighton, C.J., Ittmann, M.M. and Xin, L.
Cell Stem Cell 24 (5): 753-768. 2 May 2019

Cell and Tissue Research

Localization of mammary-derived growth inhibitor in capillary endothelial cells of the bovine mammary gland.
Breter, H. and Erdmann, B.
Cell and Tissue Research 277 : 457-464. 1 January 1994

Irregular distribution of mammary-derived growth inhibitor in the bovine mammary epithelium.
Erdmann, B. and Breter, H.
Cell and Tissue Research 272 : 383-389. 1 January 1993

Cells Tissues Organs

FGF2 signaling in mouse embryonic fibroblasts is crucial for self-renewal of embryonic stem cells.
Diecke, S., Quiroga-Negreira, A., Redmer, T. and Besser, D.
Cells Tissues Organs 188 (1-2): 52-61. July 2008

Cellular Microbiology

Keratinocyte-specific ablation of protease-activated receptor-2 prevents gingival inflammation and bone loss in a mouse model of periodontal disease.
Francis, N., Ayodele, B.A., O'Brien-Simpson, N.M., Birchmeier, W., Pike, R.N., Pagel, C.N. and Mackie, E.J.
Cellular Microbiology 20 (11): e12891. November 2018

ChemMedChem

Selective inhibitors of the protein tyrosine phosphatase SHP2 block cellular motility and growth of cancer cells in vitro and in vivo.
Grosskopf, S., Eckert, C., Arkona, C., Radetzki, S., Böhm, K., Heinemann, U., Wolber, G., von Kries, J.P., Birchmeier, W. and Rademann, J.
ChemMedChem 10 (5): 815-826. May 2015

Ciba Foundation Symposia

Role of HGF/SF and c-Met in morphogenesis and metastasis of epithelial cells.
Birchmeier, W., Brinkmann, V., Niemann, C., Meiners, S., Dicesare, S., Naundorf, H. and Sachs, M.
Ciba Foundation Symposia 212 : 230-240. 1 January 1997

E-cadherin as an invasion suppressor.
Birchmeier, W., Huelsken, J. and Behrens, J.
Ciba Foundation Symposia 189 : 124-136, discussion 136-41, 174-6. 1 January 1995

Circulation Research

Beta-catenin downregulation is required for adaptive cardiac remodeling.
Baurand, A., Zelarayan, L., Betney, R., Gehrke, C., Dunger, S., Noack, C., Busjahn, A., Huelsken, J., Taketo, M.M., Birchmeier, W., Dietz, R. and Bergmann, M.W.
Circulation Research 100 (9): 1353-1362. 11 May 2007

Effects of intracellular angiotensin II in vascular smooth muscle cells.
Haller, H., Lindschau, C., Erdmann, B., Quass, P. and Luft, F.C.
Circulation Research 79 (4): 765-772. 1 October 1996

Clinica Chimica Acta

Diagnostic and prognostic potential of circulating cell-free genomic and mitochondrial DNA fragments in clear cell renal cell carcinoma patients.
Lu, H., Busch, J., Jung, M., Rabenhorst, S., Ralla, B., Kilic, E., Mergemeier, S., Budach, N., Fendler, A. and Jung, K.
Clinica Chimica Acta 452 : 109-119. 15 January 2016

Clinical Chemistry

MicroRNA signature helps distinguish early from late biochemical failure in prostate cancer.
Lichner, Z., Fendler, A., Saleh, C., Nasser, A.N., Boles, D., Al-Haddad, S., Kupchak, P., Dharsee, M., Nuin, P.S., Evans, K.R., Jung, K., Stephan, C., Fleshner, N.E. and Yousef, G.M.
Clinical Chemistry 59 (11): 1595-1603. November 2013

Clinical Chemistry and Laboratory Medicine

Circular RNAs: a new class of biomarkers as a rising interest in laboratory medicine.
Franz, A., Rabien, A., Stephan, C., Ralla, B., Fuchs, S., Jung, K. and Fendler, A.
Clinical Chemistry and Laboratory Medicine 56 (12): 1992-2003. December 2018

Clinical and Experimental Metastasis

C-met activation is necessary but not sufficient for liver colonization by B16 murine melanoma cells.
Lin, S., Rusciano, D., Lorenzoni, P., Hartmann, G., Birchmeier, W., Giordano, S., Comoglio, P. and Burger, M.M.
Clinical and Experimental Metastasis 16 : 253-265. 1 January 1998

Differences of E-cadherin expression levels and patterns in primary and metastatic human lung cancer.
Boehm, M., Totzeck, B., Birchmeier, W. and Wieland, I.
Clinical and Experimental Metastasis 12 : 55-62. 1 January 1994

Cold Spring Harbor Perspectives in Biology

Interplay of cadherin-mediated cell adhesion and canonical wnt signaling.
Heuberger, J. and Birchmeier, W.
Cold Spring Harbor Perspectives in Biology 2 (2): a002915. February 2010

Current Biology

Engineered mutants of HGF/SF with reduced binding to heparan sulphate proteoglycans, decreased clearance and enhanced activity in vivo.
Hartmann, G., Prospero, T., Brinkmann, V., Ozcelik, O., Winter, G., Hepple, J., Batley, S., Bladt, F., Sachs, M., Birchmeier, C., Birchmeier, W. and Gherardi, E.
Current Biology 8 (3): 125-134. 29 January 1998

Current Opinion in Cell Biology

Wnt signaling in stem and cancer stem cells.
Holland, J.D., Klaus, A., Garratt, A.N. and Birchmeier, W.
Current Opinion in Cell Biology 25 (2): 254-264. April 2013

Tumor-suppressor gene products in cell contacts: the cadherin-APC-armadillo connection.
Huelsken, J., Behrens, J. and Birchmeier, W.
Current Opinion in Cell Biology 6 : 711-716. 1 January 1994

Current Opinion in Genetics & Development

Balancing cell adhesion and Wnt signaling, the key role of beta-catenin.
Brembeck, F.H., Rosario, M. and Birchmeier, W.
Current Opinion in Genetics & Development 16 (1): 51-59. February 2006

New aspects of Wnt signaling pathways in higher vertebrates.
Huelsken, J. and Birchmeier, W.
Current Opinion in Genetics & Development 11 (5): 547-553. 1 October 2001

Current Topics in Microbiology and Immunology

Epithelial differentiation and the control of metastasis in carcinomas.
Birchmeier, W., Behrens, J., Weidner, K.M., Huelsken, J. and Birchmeier, C.
Current Topics in Microbiology and Immunology : 117-135. 1 January 1996

Development

NF-κB determines Paneth versus goblet cell fate decision in the small intestine.
Brischetto, C., Krieger, K., Klotz, C., Krahn, I., Kunz, S., Kolesnichenko, M., Mucka, P., Heuberger, J., Scheidereit, C. and Schmidt-Ullrich, R.
Development 148 (21): dev199683. November 2021

Embryonic hair follicle fate change by augmented β-catenin through Shh and Bmp signaling.
Suzuki, K., Yamaguchi, Y., Villacorte, M., Mihara, K., Akiyama, M., Shimizu, H., Taketo, M.M., Nakagata, N., Tsukiyama, T., Yamaguchi, T.P., Birchmeier, W., Kato, S. and Yamada, G.
Development 136 (3): 367-372. February 2009

Sustained epithelial beta-catenin activity induces precocious hair development but disrupts hair follicle down-growth and hair shaft formation.
Naerhi, K., Jaervinen, E., Birchmeier, W., Taketo, M.M., Mikkola, M.L. and Thesleff, I.
Development 135 (6): 1019-1028. March 2008

Multiple roles of mesenchymal beta-catenin during murine limb patterning.
Hill, T.P., Taketo, M.M., Birchmeier, W. and Hartmann, C.
Development 133 (7): 1219-1229. 1 April 2006

The role of Axin2 in calvarial morphogenesis and craniosynostosis.
Yu, H.M., Jerchow, B., Sheu, T.J., Liu, B., Costantini, F., Puzas, J.E., Birchmeier, W. and Hsu, W.
Development 132 (8): 1995-2005. 1 January 2005

β-Catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation.
Morkel, M., Huelsken, J., Wakamiya, M., Ding, J., van de Wetering, M., Clevers, H., Taketo, M.M., Behringer, R.R., Shen, M.M. and Birchmeier, W.
Development 130 (25): 6283-6294. 1 January 2003

Expression of deltaNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours.
Niemann, C., Owens, D.M., Huelsken, J., Birchmeier, W. and Watt, F.M.
Development 129 : 95-109. 1 January 2002

Requirement of NF-kappaB/Rel for the development of hair follicles and other epidermal appendices.
Schmidt-Ullrich, R., Aebischer, T., Huelsken, J., Birchmeier, W., Klemm, U. and Scheidereit, C.
Development 128 (19): 3843-3853. 1 January 2001

Developmental Biology

The role of Irf6 in tooth epithelial invagination.
Blackburn, J., Ohazama, A., Kawasaki, K., Otsuka-Tanaka, Y., Liu, B., Honda, K., Rountree, R.B., Hu, Y., Kawasaki, M., Birchmeier, W., Schmidt-Ullrich, R., Kinoshita, A., Schutte, B.C., Hammond, N.L., Dixon, M.J. and Sharpe, P.T.
Developmental Biology 365 (1): 61-70. 1 May 2012

The tyrosine phosphatase Shp2 acts downstream of GDNF/Ret in branching morphogenesis of the developing mouse kidney.
Willecke, R., Heuberger, J., Grossmann, K., Michos, O., Schmidt-Ott, K., Walentin, K., Costantini, F. and Birchmeier, W.
Developmental Biology 360 (2): 310-307. 15 December 2011

Role of Epiprofin, a zinc-finger transcription factor, in limb development.
Talamillo, A., Delgado, I., Nakamura, T., de-Vega, S., Yoshitomi, Y., Unda, F., Birchmeier, W., Yamada, Y. and Ros, M.A.
Developmental Biology 337 (2): 363-374. 15 January 2010

Bmp and Wnt/beta-catenin signals control expression of the transcription factor Olig3 and the specification of spinal cord neurons.
Zechner, D., Muller, T., Wende, H., Walther, I., Taketo, M.M., Crenshaw, E.B., Treier, M., Birchmeier, W. and Birchmeier, C.
Developmental Biology 303 (1): 181-190. 1 March 2007

Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung.
Shu, W., Guttentag, S., Wang, Z., Andl, T., Ballard, P., Lu, M.M., Piccolo, S., Birchmeier, W., Whitsett, J.A., Millar, S.E. and Morrisey, E.E.
Developmental Biology 283 (1): 226-239. 1 January 2005

beta-catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system.
Zechner, D., Fujita, Y., Huelsken, J., Mueller, T., Walther, I., Taketo, M.M., Crenshaw, E.B., Birchmeier, W. and Birchmeier, C.
Developmental Biology 258 (2): 406-418. 15 June 2003

Developmental Cell

Reciprocal requirements for EDA/EDAR/NF-κB and Wnt/β-catenin signaling pathways in hair follicle induction.
Zhang, Y., Tomann, P., Andl, T., Gallant, N.M., Huelsken, J., Jerchow, B., Birchmeier, W., Paus, R., Piccolo, S., Mikkola, M.L., Morrisey, E.E., Overbeek, P.A., Scheidereit, C., Millar, S.E. and Schmidt-Ullrich, R.
Developmental Cell 17 (1): 49-61. 21 July 2009

Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes.
Hill, T.P., Spaeter, D., Taketo, M.M., Birchmeier, W. and Hartmann, C.
Developmental Cell 8 (5): 727-738. 1 May 2005

Making tubes: Step by step.
Rosario, M. and Birchmeier, W.
Developmental Cell 7 (1): 3-5. 1 July 2004

EMBO Journal

Shp2 signaling suppresses senescence in PyMT-induced mammary gland cancer in mice.
Lan, L., Holland, J.D., Qi, J., Grosskopf, S., Rademann, J., Vogel, R., Gyoerffy, B., Wulf-Goldenberg, A. and Birchmeier, W.
EMBO Journal 34 (11): 1493-1508. 3 June 2015

Wnt/β-catenin signalling induces MLL to create epigenetic changes in salivary gland tumours.
Wend, P., Fang, L., Zhu, Q., Schipper, J.H., Loddenkemper, C., Kosel, F., Brinkmann, V., Eckert, K., Hindersin, S., Holland, J.D., Lehr, S., Kahn, M., Ziebold, U. and Birchmeier, W.
EMBO Journal 32 (14): 1977-1989. 17 July 2013

Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor.
Naldini, L., Tamagnone, L., Vigna, E., Sachs, M., Hartmann, G., Birchmeier, W., Daikuhara, Y., Tsubouchi, H., Blasi, F. and Comoglio, P.M.
EMBO Journal 11 (13): 4825-4833. 1 December 1992

EMBO Molecular Medicine

Oxidized LDL-dependent pathway as new pathogenic trigger in arrhythmogenic cardiomyopathy.
Sommariva, E., Stadiotti, I., Casella, M., Catto, V., Dello Russo, A., Carbucicchio, C., Arnaboldi, L., De Metrio, S., Milano, G., Scopece, A., Casaburo, M., Andreini, D., Mushtaq, S., Conte, E., Chiesa, M., Birchmeier, W., Cogliati, E., Paolin, A., König, E., Meraviglia, V., De Musso, M., Volani, C., Cattelan, G., Rauhe, W., Turnu, L., Porro, B., Pedrazzini, M., Camera, M., Corsini, A., Tondo, C., Rossini, A. and Pompilio, G.
EMBO Molecular Medicine 13 (9): e14365. 7 September 2021

EMBO Reports

Concomitant deletion of Ptpn6 and Ptpn11 in T cells fails to improve anticancer responses.
Ventura, P.M.O., Gakovic, M., Fischer, B.A., Spinelli, L., Rota, G., Pathak, S., Khameneh, H.J., Zenobi, A., Thomson, S., Birchmeier, W., Cantrell, D.A. and Guarda, G.
EMBO Reports 23 (11): e55399. 7 November 2022

Where do you come from; where do you go? Pluripotency, differentiation and malfunction of stem cells.
Spagnoli, F.M., Besser, D. and Benitah, S.A.
EMBO Reports 13 (1): 9-11. January 2012

E-cadherin is crucial for embryonic stem cell pluripotency and can replace OCT4 during somatic cell reprogramming.
Redmer, T., Diecke, S., Grigoryan, T., Quiroga-Negreira, A., Birchmeier, W. and Besser, D.
EMBO Reports 12 (7): 720-726. 1 July 2011

Cell adhesion and signal transduction in cancer.
Birchmeier, W.
EMBO Reports 6 (5): 413-417. 1 January 2005

Endocrine Research

Human adrenal CYP11B1: localization by in situ-hybridization and functional expression in cell cultures.
Erdmann, B., Denner, K., Gerst, H., Lenz, D. and Bernhardt, R.
Endocrine Research 21 : 425-435. 1 January 1995

European Journal of Cancer

Immunohistological analysis of E-cadherin, alpha-, beta- and gamma-catenin expression in colorectal cancer: Implications for cell adhesion and signaling.
Ghadimi, B.M., Behrens, J., Hoffmann, I., Haensch, W., Birchmeier, W. and Schlag, P.M.
European Journal of Cancer 35 (1): 60-65. January 1999

European Journal of Cell Biology

Immunocytochemical localization of heterologously expressed adrenodoxin and its electron acceptor cytochrome P45011B1 in Escherichia coli.
Erdmann, B., Henning, M., Uhlmann, H., Beckert, V., Grunau, C. and Bernhardt, R.
European Journal of Cell Biology 65 : 220-228. 1 January 1994

European Journal of Immunology

The impact of c-met/scatter factor receptor on dendritic cell migration.
Kurz, S.M., Diebold, S.S., Hieronymus, T., Gust, T.C., Bartunek, P., Sachs, M., Birchmeier, W. and Zenke, M.
European Journal of Immunology 32 (7): 1832-1838. 1 January 2002

FASEB Journal

From totipotent embryonic stem cells to spontaneously contracting smooth muscle cells: a retinoic acid and db-cAMP in vitro differentiation model.
Drab, M., Haller, H., Bychkov, R., Erdmann, B., Lindschau, C., Haase, H., Morano, I., Luft, F.C. and Wobus, A.M.
FASEB Journal 11 (11): 905-915. September 1997

FEBS Letters

Beta-catenin regulates P-cadherin expression in mammary basal epithelial cells.
Faraldo, M.M., Teuliere, J., Deugnier, M.A., Birchmeier, W., Huelsken, J., Thiery, J.P., Cano, A. and Glukhova, M.A.
FEBS Letters 581 (5): 831-836. 6 March 2007

Hepatocyte growth factor/ scatter factor (HGF/SF) signals via the STAT3/APRF transcription factor in human hepatoma cells and hepatocytes.
Schaper, F., Siewert, E., Gomez-Lechon, M.J., Gatsios, P., Sachs, M., Birchmeier, W., Heinrich, P.C. and Castell, J.
FEBS Letters 405 : 99-103. 1 January 1997

Frontiers in Immunology

SHP-2 in lymphocytes' cytokine and inhibitory receptor signaling.
Niogret, C., Birchmeier, W. and Guarda, G.
Frontiers in Immunology 10 : 2468. 25 October 2019

Gastroenterology

BCL9-2 promotes early stages of intestinal tumor progression.
Brembeck, F.H., Wiese, M., Zatula, N., Grigoryan, T., Dai, Y., Fritzmann, J. and Birchmeier, W.
Gastroenterology 141 (4): 1359-1370. October 2011

A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential.
Fritzmann, J., Morkel, M., Besser, D., Budczies, J., Kosel, F., Brembeck, F.H., Stein, U., Fichtner, I., Schlag, P.M. and Birchmeier, W.
Gastroenterology 137 (11): 165-175. July 2009

The metastasis-associated gene S100A4 is a novel target of beta-catenin/T-cell factor (TCF) signaling in colon cancer.
Stein, U., Arlt, F., Walther, W., Smith, J., Waldman, T., Harris, E.D., Mertins, S.D., Heizmann, C.W., Allard, D., Birchmeier, W., Schlag, P.M. and Shoemaker, R.H.
Gastroenterology 131 (5): 1486-1500. November 2006

E-cadherin and adenomatous polyposis coli mutations are synergistic in intestinal tumor initiation in mice.
Smits, R., Ruiz, P., Diaz-Cano, S., Luz, A., Jagmohan-Changur, S., Breukel, C., Birchmeier, C., Birchmeier, W. and Fodde, R.
Gastroenterology 119 (4): 1045-1053. 1 October 2000

Genes & Development

Activation of MAPK overrides the termination of myelin growth and replaces Nrg1/ErbB3 signals during Schwann cell development and myelination.
Sheean, M.E., McShane, E., Cheret, C., Walcher, J., Müller, T., Wulf-Goldenberg, A., Hoelper, S., Garratt, A.N., Krüger, M., Rajewsky, K., Meijer, D., Birchmeier, W., Lewin, G.R., Selbach, M. and Birchmeier, C.
Genes & Development 28 (3): 290-303. 1 February 2014

Neocortical dendritic complexity is controlled during development by NOMA-GAP-dependent inhibition of Cdc42 and activation of cofilin.
Rosario, M., Schuster, S., Juettner, R., Parthasarathy, S., Tarabykin, V. and Birchmeier, W.
Genes & Development 26 (15): 1743-1757. 1 August 2012

Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice.
Grigoryan, T., Wend, P., Klaus, A. and Birchmeier, W.
Genes & Development 22 (17): 2308-2341. 1 September 2008

Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions.
Brembeck, F.H., Schwarz-Romond, T., Bakkers, J., Wilhelm, S., Hammerschmidt, M. and Birchmeier, W.
Genes & Development 18 (18): 2225-2230. 15 September 2004

Genetic interaction between Wnt/β-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb.
Soshnikova, N., Zechner, D., Huelsken, J., Mishina, Y., Behringer, R.R., Taketo, M.M., Crenshaw, E.B. and Birchmeier, W.
Genes & Development 17 (16): 1963-1968. 1 January 2003

The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling.
Schwarz-Romond, T., Asbrand, C., Bakkers, J., Kuehl, M., Schaeffer, H.J., Huelsken, J., Behrens, J., Hammerschmidt, M. and Birchmeier, W.
Genes & Development 16 (16): 2073-2084. 15 August 2002

Genes to Cells

Afadin requirement for cytokine expressions in keratinocytes during chemically induced inflammation in mice.
Yoshida, T., Iwata, T., Takai, Y., Birchmeier, W., Yamato, M. and Okano, T.
Genes to Cells 19 (11): 842-852. November 2014

Genomics

Localization of the human beta-catenin gene (CTNNB1) to 3p21: A region implicated in tumor development.
Kraus, C., Liehr, T., Huelsken, J., Behrens, J., Birchmeier, W., Grzeschik, K.H. and Ballhausen, W.G.
Genomics 23 : 272-274. 1 January 1994

Gut

New Wnt/β-catenin target genes promote experimental metastasis and migration of colorectal cancer cells through different signals.
Qi, J., Yu, Y., Akilli Öztürk, Ö., Holland, J.D., Besser, D., Fritzmann, J., Wulf-Goldenberg, A., Eckert, K., Fichtner, I. and Birchmeier, W.
Gut 65 (10): 1690-1701. October 2016

Hepatology

Deletion of the e-Cadherin gene in hepatitis-B virus-positive chinese hepatocellular carcinomas.
Slagle, B.L., Zhou, Y.Z., Birchmeier, W. and Scorsone, K.A.
Hepatology 18 (4): 757-762. 1 October 1993

Histochemistry and Cell Biology

Zone-specific localization of cytochrome P45011B1 in human adrenal tissue by PCR-derived riboprobes.
Erdmann, B., Gerst, H., Buelow, H., Lenz, D., Baehr, V. and Bernhardt, R.
Histochemistry and Cell Biology 104 : 301-307. 1 January 1995

Hypertension

Cytochrome P450-dependent renal arachidonic acid metabolism in desoxycorticosterone acetate-salt hypertensive mice.
Honeck, H., Gross, V., Erdmann, B., Kaergel, E., Neunaber, R., Milia, A.F., Schneider, W., Luft, F.C. and Schunck, W.H.
Hypertension 36 : 610-616. 1 October 2000

Subcellular localization of angiotensin II immunoreactivity in the rat cerebellar cortex.
Erdmann, B., Fuxe, K. and Ganten, D.
Hypertension 28 : 818-824. 1 January 1996

In Vitro Cellular & Developmental Biology

Hormonal induction of functional differentiation and mammary-derived growth inhibitor expression in cultured mouse mammary gland explants.
Binas, B., Spitzer, E., Zschiesche, W., Erdmann, B., Kurtz, A., Mueller, T., Niemann, C., Blenau, W. and Grosse, R.
In Vitro Cellular & Developmental Biology 28A (9-10): 625-634. September 1992

International Journal of Cancer

Mutations of the Wnt antagonist AXIN2 (Conductin) result in TCF-dependent transcription in medulloblastomas.
Koch, A., Hrychyk, A., Hartmann, W., Waha, A., Mikeska, T., Waha, A., Schueller, U., Soerensen, N., Berthold, F., Goodyer, C.G., Wiestler, O.D., Birchmeier, W., Behrens, J. and Pietsch, T.
International Journal of Cancer 121 (2): 284-291. 15 July 2007

Prognostic value of E-cadherin expression in 413 gastric carcinomas.
Gabbert, H.E., Mueller, W., Schneiders, A., Meier, S., Moll, R., Birchmeier, W. and Hommel, G.
International Journal of Cancer 69 : 184-189. 1 January 1996

International Journal of Molecular Sciences

Circular RNAs and their linear transcripts as diagnostic and prognostic tissue biomarkers in prostate cancer after prostatectomy in combination with clinicopathological factors.
Rochow, H., Jung, M., Weickmann, S., Ralla, B., Stephan, C., Elezkurtaj, S., Kilic, E., Zhao, Z., Jung, K., Fendler, A. and Franz, A.
International Journal of Molecular Sciences 21 (21): E7812. 22 October 2020

International Journal of Oncology

Expression of E-cadherin/catenin complexes in breast cancer: correlation with favourable prognostic factors and survival.
Schoenborn, I., Zschiesche, W., Behrens, J., Herrenknecht, K. and Birchmeier, W.
International Journal of Oncology 11 : 1327-1334. 1 January 1997

Japanese Journal of Cancer Research

Undercoat-constitutive proteins of cell-cell adherens junctions.
Birchmeier, W.
Japanese Journal of Cancer Research 84 : 1332-1333. 1 January 1993

Journal of Biological Chemistry

The A-kinase anchoring protein (AKAP) glycogen synthase kinase 3β interaction protein (GSKIP) regulates β-catenin through its interactions with both protein kinase A (PKA) and GSK3β.
Dema, A., Schröter, M.F., Perets, E., Skroblin, P., Moutty, M.C., Deàk, V.A., Birchmeier, W. and Klussmann, E.
Journal of Biological Chemistry 291 (37): 19618-19630. 9 September 2016

Expression of nodal, lefty-A, and lefty-B in undifferentiated human embryonic stem cells requires activation of Smad2/3.
Besser, D.
Journal of Biological Chemistry 279 (43): 45076-45084. 1 January 2004

β-catenin is required for specification of proximal/distal cell fate during lung morphogenesis.
Mucenski, M.L., Wert, S.E., Nation, J.M., Loudy, D.E., Huelsken, J., Birchmeier, W., Morrisey, E.E. and Whitsett, J.A.
Journal of Biological Chemistry 278 (41): 40231-40238. 10 October 2003

Selection of multipotent stem cells during morphogenesis of small intestinal crypts of Lieberkuehn is perturbed by stimulation of Lef-1/β-catenin signaling.
Wong, M.H., Huelsken, J., Birchmeier, W. and Gordon, J.I.
Journal of Biological Chemistry 277 (18): 15843-15850. 3 May 2002

Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL.
Sakkab, D., Lewitzky, M., Posern, G., Schaeper, U., Sachs, M., Birchmeier, W. and Feller, S.M.
Journal of Biological Chemistry 275 (15): 10772-10778. 14 April 2000

Mechanisms identified in the transcriptional control of epithelial gene expression.
Hennig, G., Loewrick, O., Birchmeier, W. and Behrens, J.
Journal of Biological Chemistry 271 : 595-602. 1 January 1996

Characterization of the scatter factor/hepatocyte growth factor gene promoter - positive and negative regulatory elements direct gene expression to mesenchymal cells.
Plaschke-Schluetter, A., Behrens, J., Gherardi, E. and Birchmeier, W.
Journal of Biological Chemistry 270 : 830-836. 1 January 1995

The motility signal of scatter factor /hepatocyte growth factor mediated through the receptor tyrosine kinase Met requires intracellular action of Ras.
Hartmann, G., Weidner, K.M., Schwarz, H. and Birchmeier, W.
Journal of Biological Chemistry 269 : 21936-21939. 1 January 1994

Journal of Cell Biology

The neurite outgrowth multiadaptor RhoGAP, NOMA-GAP, regulates neurite extension through SHP2 and Cdc42.
Rosario, M., Franke, R., Bednarski, C. and Birchmeier, W.
Journal of Cell Biology 178 (3): 503-516. 30 July 2007

c-Met is essential for wound healing in the skin.
Chmielowiec, J., Borowiak, M., Morkel, M., Stradal, T., Munz, B., Werner, S., Wehland, J., Birchmeier, C. and Birchmeier, W.
Journal of Cell Biology 177 (1): 151-162. 9 April 2007

The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells.
Schuetz, G., Rosario, M., Grimm, J., Boeckers, T.M., Gundelfinger, E.D. and Birchmeier, W.
Journal of Cell Biology 167 (5): 945-952. 6 December 2004

Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation.
Grossmann, K.S., Grund, C., Huelsken, J., Behrend, M., Erdmann, B., Franke, W.W. and Birchmeier, W.
Journal of Cell Biology 167 (1): 149-160. 11 October 2004

Helicobacter pylori CagA protein targets the c-Met receptor and enhances the motogenic response.
Churin, Y., Al Ghoul, L., Kepp, O., Meyer, T.E., Birchmeier, W. and Naumann, M.
Journal of Cell Biology 161 (2): 249-255. 28 April 2003

Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation.
Grimm, J., Sachs, M., Britsch, S., Di Cesare, S., Schwarz-Romond, T. and Birchmeier, W.
Journal of Cell Biology 154 (2): 345-354. 23 July 2001

Negative regulation of Ros receptor tyrosine kinase signaling: An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1.
Keilhack, H., Mueller, M., Boehmer, S.A., Frank, C., Weidner, K.M., Birchmeier, W., Ligensa, T., Berndt, A., Kosmehl, H., Gunther, B., Mueller, T., Birchmeier, C. and Boehmer, F.D.
Journal of Cell Biology 152 (2): 325-334. 22 January 2001

Essential role of Gab1 for signaling by the c-Met receptor in vivo.
Sachs, M., Brohmann, H., Zechner, D., Mueller, T., Huelsken, J., Walther, I., Schaeper, U., Birchmeier, C. and Birchmeier, W.
Journal of Cell Biology 150 (6): 1375-1384. 18 September 2000

Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses.
Schaeper, U., Gehring, N.H., Fuchs, K.P., Sachs, M., Kempkes, B. and Birchmeier, W.
Journal of Cell Biology 149 (7): 1419-1432. 26 June 2000

Requirement for beta-catenin in anterior-posterior axis formation in mice.
Huelsken, J., Vogel, R., Brinkmann, V., Erdmann, B., Birchmeier, C. and Birchmeier, W.
Journal of Cell Biology 148 (3): 567-578. 7 February 2000

Reconstitution of mammary gland development in vitro: Requirement of c-met and c-erbB2 signaling for branching and alveolar morphogenesis.
Niemann, C., Brinkmann, V., Spitzer, E., Hartmann, G., Sachs, M., Naundorf, H. and Birchmeier, W.
Journal of Cell Biology 143 (2): 533-545. 19 October 1998

Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart.
Ruiz, P., Brinkmann, V., Ledermann, B., Behrend, M., Grund, C., Thalhammer, C., Vogel, F., Birchmeier, C., Guenthert, U., Franke, W.W. and Birchmeier, W.
Journal of Cell Biology 135 (1): 215-225. October 1996

Motogenic and morphogenic activity of epithelial receptor tyrosine kinases.
Sachs, M., Weidner, K.M., Brinkmann, V., Walther, I., Obermeier, A., Ullrich, A. and Birchmeier, W.
Journal of Cell Biology 133 (5): 1095-1107. 3 June 1996

Hepatocyte growth factor/scatter factor induces a variety of tissue-specific morphogenic programs in epithelial cells.
Brinkmann, V., Foroutan, H., Sachs, M., Weidner, K.M. and Birchmeier, W.
Journal of Cell Biology 131 (6 Pt. 1): 1573-1586. December 1995

V-src kinase shifts the cadherin-based cell adhesion from the strong to the weak state and beta-catenin is not required for the shift.
Takeda, H., Nagafuchi, A., Yonemura, S., Tsukita, S., Behrens, J., Birchmeier, W. and Tsukita, S.
Journal of Cell Biology 131 (6 Pt. 2): 1839-1847. December 1995

Sequential requirement of hepatocyte growth factor and neuregulin in the morphogenesis and differentiation of the mammary gland.
Yang, Y., Spitzer, E., Meyer, D., Sachs, M., Niemann, C., Hartmann, G., Weidner, K.M., Birchmeier, C. and Birchmeier, W.
Journal of Cell Biology 131 (1): 215-226. October 1995

E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton.
Huelsken, J., Birchmeier, W. and Behrens, J.
Journal of Cell Biology 127 (6 Pt. 2): 2061-2069. December 1994

The Met receptor tyrosine kinase transduces motility, proliferation, andmorphogenic signals of scatter factor/ hepatocyte growth factor in epithelial cells.
Weidner, K.M., Sachs, M. and Birchmeier, W.
Journal of Cell Biology 121 (1): 145-154. April 1993

Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/?catenin complex in cells transformed with a temperature-sensitive v-SRC gene.
Behrens, J., Vakaet, L., Friis, R., Winterhager, E., van Roy, F., Mareel, M.M. and Birchmeier, W.
Journal of Cell Biology 120 (3): 757-766. February 1993

Journal of Cell Science

Molecular mechanisms leading to loss of differentiation and gain of invasiveness in epithelial cells.
Birchmeier, W., Weidner, K.M. and Behrens, J.
Journal of Cell Science Suppl. 17 : 159-164. 1 January 1993

Journal of Cellular Biochemistry

MEK Partner 1 (MP1): Regulation of oligomerization in MAP kinase signaling.
Sharma, C., Vomastek, T., Tarcsafalvi, A., Catling, A.D., Schaeffer, H.J., Eblen, S.T. and Weber, M.J.
Journal of Cellular Biochemistry 94 (4): 708-719. 1 January 2005

Plakoglobin is essential for myocardial compliance but dispensable for myofibril insertion into adherens junctions.
Isac, C.M., Ruiz, P., Pfitzmaier, B., Haase, H., Birchmeier, W. and Morano, I.
Journal of Cellular Biochemistry 72 (1): 8-15. 1 January 1999

EGF and TGFalpha modulate structural and functional differentiation of the mammary gland from pregnant mice in vitro: Possible role of the arachidomic pathway.
Spitzer, E., Zschiesche, W., Binas, B., Grosse, R. and Erdmann, B.
Journal of Cellular Biochemistry 57 : 495-508. 1 January 1995

Journal of Clinical Endocrinology and Metabolism

Clinical significance of e-cadherin as a prognostic marker in thyroid carcinomas.
Scheumman, G.F.W., Hoangvu, C., Cetin, Y., Gimm, O., Behrens, J., von Wasielewski, R., Georgii, A., Birchmeier, W., von zur Muehlen, A., Dralle, H. and Brabant, G.
Journal of Clinical Endocrinology and Metabolism 80 (7): 2168-2172. 1 January 1995

Journal of Clinical Investigation

Arrhythmogenic right ventricular cardiomyopathy: moving toward mechanism.
MacRae, C.A., Birchmeier, W. and Thierfelder, L.
Journal of Clinical Investigation 116 (7): 1825-1828. July 2006

Journal of Comparative Neurology

Specific paucity of unmyelinated C-fibers in cutaneous peripheral nerves of the African naked-mole rat: comparative analysis using six species of bathyergidae.
Smith, E.S.J., Purfürst, B., Grigoryan, T., Park, T.J., Bennett, N.C. and Lewin, G.R.
Journal of Comparative Neurology 520 (12): 2785-2803. 15 August 2012

Journal of Experimental & Clinical Cancer Research

Piwi-interacting RNAs as novel prognostic markers in clear cell renal cell carcinomas.
Busch, J., Ralla, B., Jung, M., Wotschofsky, Z., Trujillo-Arribas, E., Schwabe, P., Kilic, E., Fendler, A. and Jung, K.
Journal of Experimental & Clinical Cancer Research 34 (1): 61. 14 June 2015

Journal of Experimental Medicine

Loss of epidermal Evi/Wls results in a phenotype resembling psoriasiform dermatitis.
Augustin, I., Gross, J., Baumann, D., Korn, C., Kerr, G., Grigoryan, T., Mauch, C., Birchmeier, W. and Boutros, M.
Journal of Experimental Medicine 210 (9): 1761-1777. 26 August 2013

Journal of Medicinal Chemistry

From pyrazolones to azaindoles: evolution of active-site SHP2 inhibitors based on scaffold hopping and bioisosteric replacement.
Mostinski, Y., Heynen, G.J.J.E., López-Alberca, M.P., Paul, J., Miksche, S., Radetzki, S., Schaller, D., Shanina, E., Seyffarth, C., Kolomeets, Y., Ziebart, N., de Schryver, J., Oestreich, S., Neuenschwander, M., Roske, Y., Heinemann, U., Rademacher, C., Volkamer, A., von Kries, J.P., Birchmeier, W. and Nazaré, M.
Journal of Medicinal Chemistry 63 (23): 14780-14804. 10 December 2020

Journal of Pathology

Mutations and elevated transcriptional activity of conductin (AXIN2) in hepatoblastomas.
Koch, A., Weber, N., Waha, A., Hartmann, W., Denkhaus, D., Behrens, J., Birchmeier, W., von Schweinitz, D. and Pietsch, T.
Journal of Pathology 204 (5): 546-554. 1 January 2004

Journal of Steroid Biochemistry and Molecular Biology

Differential cross-talk of estrogen and growth factor receptors in two human mammary tumor cell lines.
Lichtner, R.B., Parczyk, K., Birchmeier, W. and Schneider, M.R.
Journal of Steroid Biochemistry and Molecular Biology 71 (5-6): 181-189. 31 December 1999

Life Science Alliance

Epigenetic modifier balances Mapk and Wnt signalling in differentiation of goblet and Paneth cells.
Grinat, J., Kosel, F., Goveas, N., Kranz, A., Alexopoulou, D., Rajewsky, K., Sigal, M., Stewart, A.F. and Heuberger, J.
Life Science Alliance 5 (4): e202101187. April 2022

A C/EBPα-Wnt connection in gut homeostasis and carcinogenesis.
Heuberger, J., Hill, U., Förster, S., Zimmermann, K., Malchin, V., Kühl, A.A., Stein, U., Vieth, M., Birchmeier, W. and Leutz, A.
Life Science Alliance 2 (1): e201800173. February 2019

Magnetic Resonance

Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling.
Kamdem, N., Roske, Y., Kovalskyy, D., Platonov, M.O., Balinskyi, O., Kreuchwig, A., Saupe, J., Fang, L., Diehl, A., Schmieder, P., Krause, G., Rademann, J., Heinemann, U., Birchmeier, W. and Oschkinat, H.
Magnetic Resonance 2 (1): 355-374. 2 June 2021

Molecular Biology of the Cell

The transcriptional repressor Glis2 is a novel binding partner for p120 catenin.
Hosking, C.R., Ulloa, F., Hogan, C., Ferber, E., Figueroa, A., Gevaert, K., Birchmeier, W., Briscoe, J. and Fujita, Y.
Molecular Biology of the Cell 18 (5): 1918-1927. 1 May 2007

Molecular Cancer Research

Global increase of p16INK4a in APC-deficient mouse liver drives clonal growth of p16INK4a negative tumors.
Ueberham, E., Glöckner, P., Göhler, C., Straub, B.K., Teupser, D., Schönig, K., Braeuning, A., Höhn, A.K., Jerchow, B., Birchmeier, W., Gaunitz, F., Arendt, T., Sansom, O., Gebhardt, R. and Ueberham, U.
Molecular Cancer Research 13 (2): 239-249. February 2015

Molecular Cancer Therapeutics

Developing antagonists for the Met-HGF/SF protein-protein interaction using a fragment-based approach.
Winter, A., Sigurdardottir, A.G., DiCara, D., Valenti, G., Blundell, T.L. and Gherardi, E.
Molecular Cancer Therapeutics 15 (1): 3-14. January 2016

Molecular Carcinogenesis

Analysis of the E-cadherin and P-cadherin promoters in murine keratinocyte cell lines from different stages of mouse skin carcinogenesis.
Faraldo, M.L.M., Rodrigo, I., Behrens, J., Birchmeier, W. and Cano, A.
Molecular Carcinogenesis 20 : 33-47. 1 January 1997

Molecular and Cellular Biology

The MEK1 scaffolding protein MP1 regulates cell spreading by integrating PAK1 and Rho signals.
Pullikuth, A., McKinnon, E., Schaeffer, H.J. and Catling, A.D.
Molecular and Cellular Biology 25 (12): 5119-5133. 1 June 2005

beta-catenin-dependent and -independent effects of deltaN-plakoglobin on epidermal growth and differentiation.
Teuliere, J., Faraldo, M.M., Shtutman, M., Birchmeier, W., Huelsken, J., Thiery, J.P. and Glukhova, M.A.
Molecular and Cellular Biology 24 (19): 8649-8661. 1 October 2004

Rap1 regulates the formation of E-cadherin-based cell-cell contacts.
Hogan, C., Serpente, N., Cogram, P., Hosking, C.R., Bialucha, C.U., Feller, S.M., Braga, V.M.M., Birchmeier, W. and Fujita, Y.
Molecular and Cellular Biology 24 (15): 6690-6700. 1 January 2004

The docking protein Gab1 is an essential component of an indirect mechanism for fibroblast growth factor stimulation of the phosphatidylinositol 3-kinase/Akt antiapoptotic pathway.
Lamothe, B., Yamada, M., Schaeper, U., Birchmeier, W., Lax, I. and Schlessinger, J.
Molecular and Cellular Biology 24 (13): 5657-5666. 1 January 2004

Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors.
Lustig, B., Jerchow, B., Sachs, M., Weiler, S., Pietsch, T., Karsten, U., van de Wetering, M., Clevers, H., Schlag, P.M., Birchmeier, W. and Behrens, J.
Molecular and Cellular Biology 22 (4): 1184-1193. 1 February 2002

Nature

Stem cells: Orphan receptors find a home.
Birchmeier, W.
Nature 476 (7360): 287-288. 18 August 2011

Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling.
Malanchi, I., Peinado, H., Kassen, D., Hussenet, T., Metzger, D., Chambon, P., Huber, M., Hohl, D., Cano, A., Birchmeier, W. and Huelsken, J.
Nature 452 (7187): 650-653. 3 April 2008

Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis.
Weidner, K.M., Dicesare, S., Sachs, M., Brinkmann, V., Behrens, J. and Birchmeier, W.
Nature 384 (6605): 173-176. 14 November 1996

Functional interaction of beta-catenin with the transcription factor LEF-1.
Behrens, J., von Kries, J.P., Kuehl, M., Bruhn, L., Wedlich, D., Grosschedl, R. and Birchmeier, W.
Nature 382 (6592): 638-642. 15 August 1996

Nature Cell Biology

Orchestrating Wnt signalling for metabolic liver zonation.
Birchmeier, W.
Nature Cell Biology 18 (5): 463-465. May 2016

Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex.
Fujita, Y., Krause, G., Scheffner, M., Zechner, D., Leddy, H.E.M., Behrens, J., Sommer, T. and Birchmeier, W.
Nature Cell Biology 4 (3): 222-231. 1 March 2002

Nature Communications

Impaired Plakophilin-2 in obesity breaks cell cycle dynamics to breed adipocyte senescence.
Lluch, A., Latorre, J., Serena-Maione, A., Espadas, I., Caballano-Infantes, E., Moreno-Navarrete, J.M., Oliveras-Cañellas, N., Ricart, W., Malagón, M.M., Martin-Montalvo, A., Birchmeier, W., Szymanski, W., Graumann, J., Gómez-Serrano, M., Sommariva, E., Fernández-Real, J.M. and Ortega, F.J.
Nature Communications 14 (1): 5106. 22 August 2023

The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness.
Grinat, J., Heuberger, J., Vidal, R., Goveas, N., Kosel, F., Berenguer-Llergo, A., Kranz, A., Wulf-Goldenberg, A., Behrens, D., Melcher, B., Sauer, S., Vieth, M., Batlle, E., Stewart, A. and Birchmeier, W.
Nature Communications 11 (1): 6422. 21 December 2020

Tracing tumorigenesis in a solid tumor model at single-cell resolution.
Praktiknjo, S.D., Obermayer, B., Zhu, Q., Fang, L., Liu, H., Quinn, H., Stoeckius, M., Kocks, C., Birchmeier, W. and Rajewsky, N.
Nature Communications 11 (1): 991. 20 February 2020

Inhibiting WNT and NOTCH in renal cancer stem cells and the implications for human patients.
Fendler, A., Bauer, D., Busch, J., Jung, K., Wulf-Goldenberg, A., Kunz, S., Song, K., Myszczyszyn, A., Elezkurtaj, S., Erguen, B., Jung, S., Chen, W. and Birchmeier, W.
Nature Communications 11 (1): 929. 17 February 2020

Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells.
Niogret, C., Miah, S.M.S., Rota, G., Fonta, N.P., Wang, H., Held, W., Birchmeier, W., Sexl, V., Yang, W., Vivier, E., Ho, P.C., Brossay, L. and Guarda, G.
Nature Communications 10 (1): 1444. 29 March 2019

The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis.
Zehender, A., Huang, J., Györfi, A.H., Matei, A.E., Trinh-Minh, T., Xu, X., Li, Y.N., Chen, C.W., Lin, J., Dees, C., Beyer, C., Gelse, K., Zhang, Z.Y., Bergmann, C., Ramming, A., Birchmeier, W., Distler, O., Schett, G. and Distler, J.H.W.
Nature Communications 9 (1): 3259. 14 August 2018

Nature Genetics

Mutations in the desmosomal protein plakophilin-2 are common in arrhythmogenic right ventricular cardiomyopathy.
Gerull, B., Heuser, A., Wichter, T., Paul, M., Basson, C.T., McDermott, D.A., Lerman, B.B., Markowitz, S.M., Ellinor, P.T., MacRae, C.A., Peters, S., Grossmann, K.S., Drenckhahn, J., Michely, B., Sasse-Klaassen, S., Birchmeier, W., Dietz, R., Breithardt, G., Schulze-Bahr, E. and Thierfelder, L.
Nature Genetics 36 (11): 1162-1164. November 2004

Nature Immunology

Hematopoietic stem cell and multilineage defects generated by constitutive beta-catenin activation.
Scheller, M., Huelsken, J., Rosenbauer, F., Taketo, M.M., Birchmeier, W., Tenen, D.G. and Leutz, A.
Nature Immunology 7 (10): 1037-1047. October 2006

Deletion of beta-catenin impairs T cell development.
Xu, Y., Banerjee, D., Huelsken, J., Birchmeier, W. and Sen, J.M.
Nature Immunology 4 (12): 1177-1182. 1 January 2003

Nature Medicine

Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase.
Ruess, D.A., Heynen, G.J., Ciecielski, K.J., Ai, J., Berninger, A., Kabacaoglu, D., Görgülü, K., Dantes, Z., Wörmann, S.M., Diakopoulos, K.N., Karpathaki, A.F., Kowalska, M., Kaya-Aksoy, E., Song, L., Zeeuw van der Laan, E.A., López-Alberca, M.P., Nazaré, M., Reichert, M., Saur, D., Erkan, M.M., Hopt, U.T., Sainz, B., Birchmeier, W., Schmid, R.M., Lesina, M. and Algül, H.
Nature Medicine 24 (7): 954-960. July 2018

MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis.
Stein, U., Walther, W., Arlt, F., Schwabe, H., Smith, J., Fichtner, I., Birchmeier, W. and Schlag, P.M.
Nature Medicine 15 (1): 59-67. January 2009

Nature Reviews Cancer

Targeting MET in cancer: rationale and progress.
Gherardi, E., Birchmeier, W., Birchmeier, C. and Woude, G.V.
Nature Reviews Cancer 12 (2): 89-103. February 2012

Wnt signalling and its impact on development and cancer.
Klaus, A. and Birchmeier, W.
Nature Reviews Cancer 8 (5): 387-398. May 2008

Nature Reviews Molecular Cell Biology

Met, metastasis, motility and more.
Birchmeier, C., Birchmeier, W., Gherardi, E. and Vande Woude, G.F.
Nature Reviews Molecular Cell Biology 4 (12): 915-925. December 2003

Nature Reviews Urology

The translational potential of microRNAs as biofluid markers of urological tumours.
Fendler, A., Stephan, C., Yousef, G.M., Kristiansen, G. and Jung, K.
Nature Reviews Urology 13 (12): 734-752. December 2016

Nature Structural Biology

Hot spots in beta-catenin for interactions with LEF-1, conductin and APC.
von Kries, J.P., Winbeck, G., Asbrand, C., Schwarz-Romond, T., Sochnikova, N., Dell'Oro, A., Behrens, J. and Birchmeier, W.
Nature Structural Biology 7 : 800-807. 1 January 2000

Neurochemical Research

Expression of multidrug resistance proteins (Mrps) in astrocytes of the mouse brain: a single cell rt-PCR study.
Hirrlinger, J., Moeller, H., Kirchhoff, F. and Dringen, R.
Neurochemical Research 30 (10): 1237-1244. 1 October 2005

Neuron

Wnt-Fzd signaling sensitizes peripheral sensory neurons via distinct noncanonical pathways.
Simonetti, M., Agarwal, N., Stösser, S., Bali, K.K., Karaulanov, E., Kamble, R., Pospisilova, B., Kurejova, M., Birchmeier, W., Niehrs, C., Heppenstall, P. and Kuner, R.
Neuron 83 (1): 104-121. 2 July 2014

Role of β-catenin in synaptic vesicle localization and presynaptic assembly.
Bamji, S.X., Shimazu, K., Kimes, N., Huelsken, J., Birchmeier, W., Lu, B. and Reichardt, L.F.
Neuron 40 (4): 719-731. November 2003

Nucleic Acids Research

Homogeneity and persistence of transgene expression by omitting antibiotic selection in cell line isolation.
Kaufman, W.L., Kocman, I., Agrawal, V., Rahn, H.P., Besser, D. and Gossen, M.
Nucleic Acids Research 36 (17): e111. October 2008

Oncogene

The C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motif.
Lewitzky, M., Kardinal, C., Gehring, N.H., Schmidt, E.K., Konkol, B., Eulitz, M., Birchmeier, W., Schaeper, U. and Feller, S.M.
Oncogene 20 (9): 1052-1062. 1 January 2001

Tumour-associated E-cadherin mutations alter cellular morphology, decrease cellular adhesion and increase cellular motility.
Handschuh, G., Candidus, S., Luber, B., Reich, U., Schott, C., Oswald, S., Becke, H., Hutzler, P., Birchmeier, W., Hoefler, H. and Becker, K.F.
Oncogene 18 : 4301-4312. 29 July 1999

Role of morphogenetic factors in metastasis of mammary carcinoma cells.
Meiners, S., Brinkmann, V., Naundorf, H. and Birchmeier, W.
Oncogene 16 : 9-20. 1 January 1998

Progression of carcinoma cells is associated with alterations in chromatin structure and factor binding at the E-cadherin promoter in vivo.
Hennig, G., Behrens, J., Truss, M., Frisch, S., Reichmann, E. and Birchmeier, W.
Oncogene 11 : 475-484. 1 January 1995

Oncotarget

Heregulin-HER3-HER2 signaling promotes matrix metalloproteinase-dependent blood-brain-barrier transendothelial migration of human breast cancer cell lines.
Momeny, M., Saunus, J.M., Marturana, F., McCart Reed, A.E., Black, D., Sala, G., Iacobelli, S., Holland, J.D., Yu, D., Da Silva, L., Simpson, P.T., Khanna, K.K., Chenevix-Trench, G. and Lakhani, S.R.
Oncotarget 6 (6): 3932-3946. 19 February 2015

The BCL9-2 proto-oncogene governs estrogen receptor alpha expression in breast tumorigenesis.
Zatula, N., Wiese, M., Bunzendahl, J., Birchmeier, W., Perske, C., Bleckmann, A. and Brembeck, F.H.
Oncotarget 5 (16): 6770-6787. 30 August 2014

PLoS Genetics

MLL1 is required for maintenance of intestinal stem cells.
Goveas, N., Waskow, C., Arndt, K., Heuberger, J., Zhang, Q., Alexopoulou, D., Dahl, A., Birchmeier, W., Anastassiadis, K., Stewart, A.F. and Kranz, A.
PLoS Genetics 17 (12): e1009250. 3 December 2021

Identification of Y-box binding protein 1 as a core regulator of MEK/ERK pathway-dependent gene signatures in colorectal cancer cells.
Juerchott, K., Kuban, R.J., Krech, T., Blüthgen, N., Stein, U., Walther, W., Friese, C., Kielbasa, S.M., Ungethuem, U., Lund, P., Knoesel, T., Kemmner, W., Morkel, M., Fritzmann, J., Schlag, P.M., Birchmeier, W., Krueger, T., Sperling, S., Sers, C., Royer, H.D., Herzel, H. and Schaefer, R.
PLoS Genetics 6 (12): e1001231. 2 December 2010

PLoS ONE

Mice with renal-specific alterations 1 of stem cell-associated signaling develop symptoms of chronic kidney disease but surprisingly no tumors.
Myszczyszyn, A., Popp, O., Kunz, S., Sporbert, A., Jung, S., Penning, L.C., Fendler, A., Mertins, P. and Birchmeier, W.
PLoS ONE 19 (3): e0282938. 21 March 2024

Beneficial effect of voluntary physical exercise in Plakophilin2 transgenic mice.
Hammer, K.P., Mustroph, J., Stauber, T., Birchmeier, W., Wagner, S. and Maier, L.S.
PLoS ONE 16 (6): e0252649. 4 June 2021

Pediatric Cardiology

Developmental signaling in myocardial progenitor cells: A comprehensive view of Bmp- and Wnt/beta-catenin signaling.
Klaus, A. and Birchmeier, W.
Pediatric Cardiology 30 (5): 609-616. July 2009

Proceedings of the National Academy of Sciences of the United States of America

High Yap and Mll1 promote a persistent regenerative cell state induced by Notch signaling and loss of p53.
Heuberger, J., Grinat, J., Kosel, F., Liu, L., Kunz, S., Vidal, R.O., Keil, M., Haybaeck, J., Robine, S., Louvard, D., Regenbrecht, C., Sporbert, A., Sauer, S., von Eyss, B., Sigal, M. and Birchmeier, W.
Proceedings of the National Academy of Sciences of the United States of America 118 (22): e2019699118. 1 June 2021

Shp2/MAPK signaling controls goblet/paneth cell fate decisions in the intestine.
Heuberger, J., Kosel, F., Qi, J., Grossmann, K.S., Rajewsky, K. and Birchmeier, W.
Proceedings of the National Academy of Sciences of the United States of America 111 (9): 3472-3477. 4 March 2014

Wnt/Rspondin/β-catenin signals control axonal sorting and lineage progression in Schwann cell development.
Grigoryan, T., Stein, S., Qi, J., Wende, H., Garratt, A.N., Nave, K.A., Birchmeier, C. and Birchmeier, W.
Proceedings of the National Academy of Sciences of the United States of America 110 (45): 18174-18179. 5 November 2013

Wnt/beta-catenin and Bmp signals control distinct sets of transcription factors in cardiac progenitor cells.
Klaus, A., Mueller, M., Schulz, H., Saga, Y., Martin, J.F. and Birchmeier, W.
Proceedings of the National Academy of Sciences of the United States of America 109 (27): 10921-10926. 3 July 2012

Two isoforms of human RNA polymerase III with specific functions in cell growth and transformation.
Haurie, V., Durrieu-Gaillard, S., Dumay-Odelot, H., Da Silva, D., Rey, C., Prochazkova, M., Roeder, R.G., Besser, D. and Teichmann, M.
Proceedings of the National Academy of Sciences of the United States of America 107 (9): 4176-4181. 2 March 2010

The tyrosine phosphatase Shp2 (PTPN11) directs neuregulin-1/ErbB signaling throughout schwann cell development.
Grossmann, K.S., Wende, H., Paul, F.E., Cheret, C., Garratt, A.N., Zurborg, S., Feinberg, K., Besser, D., Schulz, H., Peles, E., Selbach, M., Birchmeier, W. and Birchmeier, C.
Proceedings of the National Academy of Sciences of the United States of America 106 (39): 16704-16709. 29 September 2009

Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking.
Hellmuth, K., Grosskopf, S., Lum, C.T., Wuertele, M., Roeder, N., von Kries, J.P., Rosario, M., Rademann, J. and Birchmeier, W.
Proceedings of the National Academy of Sciences of the United States of America 105 (20): 7275-7280. 20 May 2008

Distinct roles of Wnt/beta-catenin and Bmp signaling during early cardiogenesis.
Klaus, A., Saga, Y., Taketo, M.M., Tzahor, E. and Birchmeier, W.
Proceedings of the National Academy of Sciences of the United States of America 104 (47): 18531-18536. 20 November 2007

Distinct requirements for Gab1 in Met and EGF receptor signaling in vivo.
Schaeper, U., Vogel, R., Chmielowiec, J., Huelsken, J., Rosario, M. and Birchmeier, W.
Proceedings of the National Academy of Sciences of the United States of America 104 (39): 15376-15381. 25 September 2007

Continuous tooth generation in mouse is induced by activated epithelial Wnt/β-catenin signaling.
Jaervinen, E., Salazar-Ciudad, I., Birchmeier, W., Taketo, M.M., Jernvall, J. and Thesleff, I.
Proceedings of the National Academy of Sciences of the United States of America 103 (49): 18627-18632. 5 December 2006

Diversin regulates heart formation and gastrulation movements in development.
Moeller, H., Jenny, A., Schaeffer, H.J., Schwarz-Romond, T., Mlodzik, M., Hammerschmidt, M. and Birchmeier, W.
Proceedings of the National Academy of Sciences of the United States of America 103 (43): 15900-15905. 24 October 2006

Aberrant Wnt/beta-catenin signaling can induce chromosomal instability in colon cancer.
Hadjihannas, M.V., Brueckner, M., Jerchow, B., Birchmeier, W., Dietmaier, W. and Behrens, J.
Proceedings of the National Academy of Sciences of the United States of America 103 (28): 10747-10752. 11 July 2006

Mutation of juxtamembrane tyrosine residue 1001 suppresses loss-of-function mutations of the met receptor in epithelial cells.
Weidner, K.M., Sachs, M., Riethmacher, D. and Birchmeier, W.
Proceedings of the National Academy of Sciences of the United States of America 92 : 2597-2601. 1 January 1995

E-cadherin gene mutations in human gastric carcinoma cell lines.
Oda, T., Kanai, Y., Oyama, T., Yoshiura, K., Shimoyama, Y., Birchmeier, W., Sugimura, T. and Hirohashi, S.
Proceedings of the National Academy of Sciences of the United States of America 91 (5): 1858-1862. 1 March 1994

A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesis.
Hartmann, G., Naldini, L., Weidner, K.M., Sachs, M., Vigna, E., Comoglio, P.M. and Birchmeier, W.
Proceedings of the National Academy of Sciences of the United States of America 89 : 11574-11578. 1 January 1992

Research Square

Establishment of kidney cancer organoid cultures.
Bauer, D., Birchmeier, W. and Fendler, A.
Research Square : rs.3.pex-911. 12 May 2020

Science

Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta.
Behrens, J., Jerchow, B.A., Wuertele, M., Grimm, J., Asbrand, C., Wirtz, R., Kuehl, M., Wedlich, D. and Birchmeier, W.
Science 280 (5363): 596-599. 24 April 1998

Scientific Reports

Characterization and structural determination of a new anti-MET function-blocking antibody with binding epitope distinct from the ligand binding domain.
DiCara, D.M., Chirgadze, D.Y., Pope, A.R., Karatt-Vellatt, A., Winter, A., Slavny, P., van den Heuvel, J., Parthiban, K., Holland, J., Packman, L.C., Mavria, G., Hoffmann, J., Birchmeier, W., Gherardi, E. and McCafferty, J.
Scientific Reports 7 (1): 9000. 21 August 2017

Scientist

Hot papers in cell biology - J. Behrens, J.P. von Kries, M. Kuehl, L. Bruhn, D. Wedlich, R. Grosschedl, W. Birchmeier: "Functional interaction of beta-catenin with the transcription factor LEF-1" - Comments by Walter Birchmeier.
Birchmeier, W.
Scientist 13(8) : 15. 12 April 1999

Seminars in Cancer Biology

Molecular mechanisms leading to cell junction (cadherin) deficiency in invasive carcinomas.
Birchmeier, W., Weidner, K.M., Huelsken, J. and Behrens, J.
Seminars in Cancer Biology 4 (4): 231-239. 1 August 1993

Seminars in Cell & Developmental Biology

Wnt signaling in stem and cancer stem cells.
Wend, P., Holland, J.D., Ziebold, U. and Birchmeier, W.
Seminars in Cell & Developmental Biology 21 (8): 855-863. October 2010

Seminars in Cell Biology

Cell adhesion in invasion and metastasis.
Behrens, J., Frixen, U., Schipper, J., Weidner, K.M. and Birchmeier, W.
Seminars in Cell Biology 3 : 169-178. 1 January 1992

Theranostics

Instability of circular RNAs in clinical tissue samples impairs their reliable expression analysis using RT-qPCR: from the myth of their advantage as biomarkers to reality.
Rochow, H., Franz, A., Jung, M., Weickmann, S., Ralla, B., Kilic, E., Stephan, C., Fendler, A. and Jung, K.
Theranostics 10 (20): 9268-9279. 23 July 2020

Translational Andrology and Urology

Identification of miR-21-5p and miR-210-3p serum levels as biomarkers for patients with papillary renal cell carcinoma: a multicenter analysis.
Kalogirou, C., Ellinger, J., Kristiansen, G., Hatzichristodoulou, G., Kübler, H., Kneitz, B., Busch, J. and Fendler, A.
Translational Andrology and Urology 9 (3): 1314-1322. June 2020

Trends in Cardiovascular Medicine

The plakoglobin knock-out mouse: A paradigm for the molecular analysis of cardiac cell junction formation.
Ruiz, P. and Birchmeier, W.
Trends in Cardiovascular Medicine 8 (3): 97-101. April 1998

Trends in Cell Biology

How to make tubes: signaling by the Met receptor tyrosine kinase.
Rosario, M. and Birchmeier, W.
Trends in Cell Biology 13 (6): 328-335. June 2003

Tumor Biology

Effects of silibinin on growth and invasive properties of human ovarian carcinoma cells through suppression of heregulin/HER3 pathway.
Momeny, M., Ghasemi, R., Valenti, G., Miranda, M., Zekri, A., Zarrinrad, G., Javadikooshesh, S., Yaghmaie, M., Alimoghaddam, K., Ghavamzadeh, A. and Ghaffari, S.H.
Tumor Biology 37 (3): 3913-3923. March 2016

Urologe

UroFors: Konstituierung eines Interessensverbundes fuer Naturwissenschaftler in der urologischen Forschung [UroFors: establishment of an interest group for natural scientists in urological research].
Stope, M.B., Dansranjavin, T., Erb, H., Erdmann, K., Fendler, A., Hoelters, S., Juengel, E., Nitschke, K., Salomo, K., Seidel, P., Skowron, M.A., Wach, S. and Becker, C.
Urologe 56 (4): 515-518. April 2017

Virchows Archiv

E-Cadherin in human brain tumours: loss of immunoreactivity in malignant meningiomas.
Schwechheimer, K., Zhou, L. and Birchmeier, W.
Virchows Archiv 432 : 163-167. 1 January 1998

Zellbiologie Aktuell

Deciphering the function of signaling pathways by tissue specific gene modification in mice.
Zechner, D., Soshnikova, N. and Birchmeier, W.
Zellbiologie Aktuell 30 (1): 6-8. January 2004

bioRxiv

YAP and β-catenin co-operate to drive oncogenesis in basal breast cancer.
Quinn, H., Koren, E., Vogel, R., Popp, O., Mertins, P., Messerschmidt, C., Marangoni, E., Fuchs, Y. and Birchmeier, W.
bioRxiv : 2020.06.05.115881. 6 June 2020

Loss of the Wnt/β-catenin pathway in microglia of the developing brain drives pro-inflammatory activation leading to white matter injury.
Van Steenwinckel, J., Schang, A.L., Krishnan, M.L., Degos, V., Delahaye-Duriez, A., Bokobza, C., Verdonk, F., Montane, A., Sigaut, S., Hennebert, O., Lebon, S., Schwendimann, L., Le Charpentier, T., Hassan-Abdi, R., Ball, G., Aljabar, P., Saxena, A., Holloway, R.K., Birchmeier, W., Miron, V., Rowitch, D., Chretien, F., Leconte, C., Besson, V.C., Petretto, E.G., Edwards, A.D., Hagberg, H., Soussi-Yanicostas, N., Fleiss, B. and Gressens, P.
bioRxiv : 334359. 31 May 2018