2024
Mice with renal-specific alterations 1 of stem cell-associated signaling develop symptoms of chronic kidney disease but surprisingly no tumors.
Myszczyszyn, A. and Popp, O. and Kunz, S. and Sporbert, A. and Jung, S. and Penning, L.C. and Fendler, A. and Mertins, P. and Birchmeier, W.
PLoS ONE 19
(3): e0282938.
21 March 2024
2023
Impaired Plakophilin-2 in obesity breaks cell cycle dynamics to breed adipocyte senescence.
Lluch, A. and Latorre, J. and Serena-Maione, A. and Espadas, I. and Caballano-Infantes, E. and Moreno-Navarrete, J.M. and Oliveras-Cañellas, N. and Ricart, W. and Malagón, M.M. and Martin-Montalvo, A. and Birchmeier, W. and Szymanski, W. and Graumann, J. and Gómez-Serrano, M. and Sommariva, E. and Fernández-Real, J.M. and Ortega, F.J.
Nature Communications 14
(1): 5106.
22 August 2023
2022
Concomitant deletion of Ptpn6 and Ptpn11 in T cells fails to improve anticancer responses.
Ventura, P.M.O. and Gakovic, M. and Fischer, B.A. and Spinelli, L. and Rota, G. and Pathak, S. and Khameneh, H.J. and Zenobi, A. and Thomson, S. and Birchmeier, W. and Cantrell, D.A. and Guarda, G.
EMBO Reports 23
(11): e55399.
7 November 2022
Targeting Wnt/β-catenin signaling by TET1/FOXO4 inhibits metastatic spreading and self-renewal of cancer stem cells in gastric cancer.
Qi, J. and Cui, D. and Wu, Q.N. and Zhao, Q. and Chen, Z.H. and Li, L. and Birchmeier, W. and Yu, Y. and Tao, R.
Cancers 14
(13): 3232.
30 June 2022
Targeting SHP2 phosphatase in breast cancer overcomes RTK-mediated resistance to PI3K inhibitors.
Heynen, G.J.J.E. and Lisek, K. and Vogel, R. and Wulf-Goldenberg, A. and Alcaniz, J. and Montaudon, E. and Marangoni, E. and Birchmeier, W.
Breast Cancer Research 24
(1): 23.
1 April 2022
2021
MLL1 is required for maintenance of intestinal stem cells.
Goveas, N. and Waskow, C. and Arndt, K. and Heuberger, J. and Zhang, Q. and Alexopoulou, D. and Dahl, A. and Birchmeier, W. and Anastassiadis, K. and Stewart, A.F. and Kranz, A.
PLoS Genetics 17
(12): e1009250.
3 December 2021
NF-κB determines Paneth versus goblet cell fate decision in the small intestine.
Brischetto, C. and Krieger, K. and Klotz, C. and Krahn, I. and Kunz, S. and Kolesnichenko, M. and Mucka, P. and Heuberger, J. and Scheidereit, C. and Schmidt-Ullrich, R.
Development 148
(21): dev199683.
November 2021
Oxidized LDL-dependent pathway as new pathogenic trigger in arrhythmogenic cardiomyopathy.
Sommariva, E. and Stadiotti, I. and Casella, M. and Catto, V. and Dello Russo, A. and Carbucicchio, C. and Arnaboldi, L. and De Metrio, S. and Milano, G. and Scopece, A. and Casaburo, M. and Andreini, D. and Mushtaq, S. and Conte, E. and Chiesa, M. and Birchmeier, W. and Cogliati, E. and Paolin, A. and König, E. and Meraviglia, V. and De Musso, M. and Volani, C. and Cattelan, G. and Rauhe, W. and Turnu, L. and Porro, B. and Pedrazzini, M. and Camera, M. and Corsini, A. and Tondo, C. and Rossini, A. and Pompilio, G.
EMBO Molecular Medicine 13
(9): e14365.
7 September 2021
Beneficial effect of voluntary physical exercise in Plakophilin2 transgenic mice.
Hammer, K.P. and Mustroph, J. and Stauber, T. and Birchmeier, W. and Wagner, S. and Maier, L.S.
PLoS ONE 16
(6): e0252649.
4 June 2021
Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling.
Kamdem, N. and Roske, Y. and Kovalskyy, D. and Platonov, M.O. and Balinskyi, O. and Kreuchwig, A. and Saupe, J. and Fang, L. and Diehl, A. and Schmieder, P. and Krause, G. and Rademann, J. and Heinemann, U. and Birchmeier, W. and Oschkinat, H.
Magnetic Resonance 2
(1): 355-374.
2 June 2021
High Yap and Mll1 promote a persistent regenerative cell state induced by Notch signaling and loss of p53.
Heuberger, J. and Grinat, J. and Kosel, F. and Liu, L. and Kunz, S. and Vidal, R.O. and Keil, M. and Haybaeck, J. and Robine, S. and Louvard, D. and Regenbrecht, C. and Sporbert, A. and Sauer, S. and von Eyss, B. and Sigal, M. and Birchmeier, W.
Proceedings of the National Academy of Sciences of the United States of America 118
(22): e2019699118.
1 June 2021
The discriminative ability of Prostate Health Index to detect prostate cancer is enhanced in combination with miR-222-3p.
Tölle, A. and Jung, K. and Friedersdorff, F. and Maxeiner, A. and Lein, M. and Fendler, A. and Stephan, C.
Cancer Biomarkers 30
(4): 381-393.
9 April 2021
YAP and β-catenin cooperate to drive oncogenesis in basal breast cancer.
Quinn, H.M. and Vogel, R. and Popp, O. and Mertins, P. and Lan, L. and Messerschmidt, C. and Landshammer, A. and Lisek, K. and Château-Joubert, S. and Marangoni, E. and Koren, E. and Fuchs, Y. and Birchmeier, W.
Cancer Research 81
(8): 2116-2127.
April 2021
2020
The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness.
Grinat, J. and Heuberger, J. and Vidal, R. and Goveas, N. and Kosel, F. and Berenguer-Llergo, A. and Kranz, A. and Wulf-Goldenberg, A. and Behrens, D. and Melcher, B. and Sauer, S. and Vieth, M. and Batlle, E. and Stewart, A. and Birchmeier, W.
Nature Communications 11
(1): 6422.
21 December 2020
From pyrazolones to azaindoles: evolution of active-site SHP2 inhibitors based on scaffold hopping and bioisosteric replacement.
Mostinski, Y. and Heynen, G.J.J.E. and López-Alberca, M.P. and Paul, J. and Miksche, S. and Radetzki, S. and Schaller, D. and Shanina, E. and Seyffarth, C. and Kolomeets, Y. and Ziebart, N. and de Schryver, J. and Oestreich, S. and Neuenschwander, M. and Roske, Y. and Heinemann, U. and Rademacher, C. and Volkamer, A. and von Kries, J.P. and Birchmeier, W. and Nazaré, M.
Journal of Medicinal Chemistry 63
(23): 14780-14804.
10 December 2020
MLL1 is required for maintenance of intestinal stem cells and the expression of the cell adhesion molecule JAML.
Goveas, N. and Waskow, C. and Arndt, K. and Heuberger, J. and Zhang, Q. and Alexopoulou, D. and Dahl, A. and Birchmeier, W. and Anastassiadis, K. and Stewart, A.F. and Kranz, A.
bioRxiv
: 2020.11.19.389528.
19 November 2020
Circular RNAs and their linear transcripts as diagnostic and prognostic tissue biomarkers in prostate cancer after prostatectomy in combination with clinicopathological factors.
Rochow, H. and Jung, M. and Weickmann, S. and Ralla, B. and Stephan, C. and Elezkurtaj, S. and Kilic, E. and Zhao, Z. and Jung, K. and Fendler, A. and Franz, A.
International Journal of Molecular Sciences 21
(21): E7812.
22 October 2020
Instability of circular RNAs in clinical tissue samples impairs their reliable expression analysis using RT-qPCR: from the myth of their advantage as biomarkers to reality.
Rochow, H. and Franz, A. and Jung, M. and Weickmann, S. and Ralla, B. and Kilic, E. and Stephan, C. and Fendler, A. and Jung, K.
Theranostics 10
(20): 9268-9279.
23 July 2020
YAP and β-catenin co-operate to drive oncogenesis in basal breast cancer.
Quinn, H. and Koren, E. and Vogel, R. and Popp, O. and Mertins, P. and Messerschmidt, C. and Marangoni, E. and Fuchs, Y. and Birchmeier, W.
bioRxiv
: 2020.06.05.115881.
6 June 2020
Identification of miR-21-5p and miR-210-3p serum levels as biomarkers for patients with papillary renal cell carcinoma: a multicenter analysis.
Kalogirou, C. and Ellinger, J. and Kristiansen, G. and Hatzichristodoulou, G. and Kübler, H. and Kneitz, B. and Busch, J. and Fendler, A.
Translational Andrology and Urology 9
(3): 1314-1322.
June 2020
Establishment of kidney cancer organoid cultures.
Bauer, D. and Birchmeier, W. and Fendler, A.
Research Square
: rs.3.pex-911.
12 May 2020
Tracing tumorigenesis in a solid tumor model at single-cell resolution.
Praktiknjo, S.D. and Obermayer, B. and Zhu, Q. and Fang, L. and Liu, H. and Quinn, H. and Stoeckius, M. and Kocks, C. and Birchmeier, W. and Rajewsky, N.
Nature Communications 11
(1): 991.
20 February 2020
Inhibiting WNT and NOTCH in renal cancer stem cells and the implications for human patients.
Fendler, A. and Bauer, D. and Busch, J. and Jung, K. and Wulf-Goldenberg, A. and Kunz, S. and Song, K. and Myszczyszyn, A. and Elezkurtaj, S. and Erguen, B. and Jung, S. and Chen, W. and Birchmeier, W.
Nature Communications 11
(1): 929.
17 February 2020
2019
Decreased microglial Wnt/β-catenin signalling drives microglial pro-inflammatory activation in the developing brain.
Van Steenwinckel, J. and Schang, A.L. and Krishnan, M.L. and Degos, V. and Delahaye-Duriez, A. and Bokobza, C. and Csaba, Z. and Verdonk, F. and Montané, A. and Sigaut, S. and Hennebert, O. and Lebon, S. and Schwendimann, L. and Le Charpentier, T. and Hassan-Abdi, R. and Ball, G. and Aljabar, P. and Saxena, A. and Holloway, R.K. and Birchmeier, W. and Baud, O. and Rowitch, D. and Miron, V. and Chretien, F. and Leconte, C. and Besson, V.C. and Petretto, E.G. and Edwards, A.D. and Hagberg, H. and Soussi-Yanicostas, N. and Fleiss, B. and Gressens, P.
Brain 142
(12): 3806-3833.
December 2019
SHP-2 in lymphocytes' cytokine and inhibitory receptor signaling.
Niogret, C. and Birchmeier, W. and Guarda, G.
Frontiers in Immunology 10
: 2468.
25 October 2019
A novel predictor tool of biochemical recurrence after radical prostatectomy based on a five-microRNA tissue signature.
Zhao, Z. and Weickmann, S. and Jung, M. and Lein, M. and Kilic, E. and Stephan, C. and Erbersdobler, A. and Fendler, A. and Jung, K.
Cancers 11
(10): 1603.
21 October 2019
Circular RNAs in clear cell renal cell carcinoma: their microarray-based identification, analytical validation, and potential use in a clinico-genomic model to improve prognostic accuracy.
Franz, A. and Ralla, B. and Weickmann, S. and Jung, M. and Rochow, H. and Stephan, C. and Erbersdobler, A. and Kilic, E. and Fendler, A. and Jung, K.
Cancers 11
(10): 1473.
30 September 2019
Spatially restricted stromal Wnt signaling restrains prostate epithelial progenitor growth through direct and indirect mechanisms.
Wei, X. and Zhang, L. and Zhou, Z. and Kwon, O.J. and Zhang, Y. and Nguyen, H. and Dumpit, R. and True, L. and Nelson, P. and Dong, B. and Xue, W. and Birchmeier, W. and Taketo, M.M. and Xu, F. and Creighton, C.J. and Ittmann, M.M. and Xin, L.
Cell Stem Cell 24
(5): 753-768.
2 May 2019
KLF4 functions as an oncogene in promoting cancer stem cell-like characteristics in osteosarcoma cells.
Qi, X.T. and Li, Y.L. and Zhang, Y.Q. and Xu, T. and Lu, B. and Fang, L. and Gao, J.Q. and Yu, L.S. and Zhu, D.F. and Yang, B. and He, Q.J. and Ying, M.D.
Acta Pharmacologica Sinica 40
(4): 546-555.
April 2019
Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells.
Niogret, C. and Miah, S.M.S. and Rota, G. and Fonta, N.P. and Wang, H. and Held, W. and Birchmeier, W. and Sexl, V. and Yang, W. and Vivier, E. and Ho, P.C. and Brossay, L. and Guarda, G.
Nature Communications 10
(1): 1444.
29 March 2019
A C/EBPα-Wnt connection in gut homeostasis and carcinogenesis.
Heuberger, J. and Hill, U. and Förster, S. and Zimmermann, K. and Malchin, V. and Kühl, A.A. and Stein, U. and Vieth, M. and Birchmeier, W. and Leutz, A.
Life Science Alliance 2
(1): e201800173.
February 2019
The Wnt-driven Mll1 epigenome regulates salivary gland and head and neck cancer.
Zhu, Q. and Fang, L. and Heuberger, J. and Kranz, A. and Schipper, J. and Scheckenbach, K. and Oliveira Vidal, R. and Sunaga-Franze, D.Y. and Müller, M. and Wulf-Goldenberg, A. and Sauer, S. and Birchmeier, W.
Cell Reports 26
(2): 415-428.
8 January 2019
2018
Circular RNAs: a new class of biomarkers as a rising interest in laboratory medicine.
Franz, A. and Rabien, A. and Stephan, C. and Ralla, B. and Fuchs, S. and Jung, K. and Fendler, A.
Clinical Chemistry and Laboratory Medicine 56
(12): 1992-2003.
December 2018
Keratinocyte-specific ablation of protease-activated receptor-2 prevents gingival inflammation and bone loss in a mouse model of periodontal disease.
Francis, N. and Ayodele, B.A. and O'Brien-Simpson, N.M. and Birchmeier, W. and Pike, R.N. and Pagel, C.N. and Mackie, E.J.
Cellular Microbiology 20
(11): e12891.
November 2018
miR-9-5p in nephrectomy specimens is a potential predictor of primary resistance to first-line treatment with tyrosine kinase inhibitors in patients with metastatic renal cell carcinoma.
Ralla, B. and Busch, J. and Flörcken, A. and Westermann, J. and Zhao, Z. and Kilic, E. and Weickmann, S. and Jung, M. and Fendler, A. and Jung, K.
Cancers 10
(9): 321.
10 September 2018
The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis.
Zehender, A. and Huang, J. and Györfi, A.H. and Matei, A.E. and Trinh-Minh, T. and Xu, X. and Li, Y.N. and Chen, C.W. and Lin, J. and Dees, C. and Beyer, C. and Gelse, K. and Zhang, Z.Y. and Bergmann, C. and Ramming, A. and Birchmeier, W. and Distler, O. and Schett, G. and Distler, J.H.W.
Nature Communications 9
(1): 3259.
14 August 2018
Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase.
Ruess, D.A. and Heynen, G.J. and Ciecielski, K.J. and Ai, J. and Berninger, A. and Kabacaoglu, D. and Görgülü, K. and Dantes, Z. and Wörmann, S.M. and Diakopoulos, K.N. and Karpathaki, A.F. and Kowalska, M. and Kaya-Aksoy, E. and Song, L. and Zeeuw van der Laan, E.A. and López-Alberca, M.P. and Nazaré, M. and Reichert, M. and Saur, D. and Erkan, M.M. and Hopt, U.T. and Sainz, B. and Birchmeier, W. and Schmid, R.M. and Lesina, M. and Algül, H.
Nature Medicine 24
(7): 954-960.
July 2018
Loss of the Wnt/β-catenin pathway in microglia of the developing brain drives pro-inflammatory activation leading to white matter injury.
Van Steenwinckel, J. and Schang, A.L. and Krishnan, M.L. and Degos, V. and Delahaye-Duriez, A. and Bokobza, C. and Verdonk, F. and Montane, A. and Sigaut, S. and Hennebert, O. and Lebon, S. and Schwendimann, L. and Le Charpentier, T. and Hassan-Abdi, R. and Ball, G. and Aljabar, P. and Saxena, A. and Holloway, R.K. and Birchmeier, W. and Miron, V. and Rowitch, D. and Chretien, F. and Leconte, C. and Besson, V.C. and Petretto, E.G. and Edwards, A.D. and Hagberg, H. and Soussi-Yanicostas, N. and Fleiss, B. and Gressens, P.
bioRxiv
: 334359.
31 May 2018
Shp-2 is dispensable for establishing T cell exhaustion and for PD-1 signaling in vivo.
Rota, G. and Niogret, C. and Dang, A.T. and Barros, C.R. and Fonta, N.P. and Alfei, F. and Morgado, L. and Zehn, D. and Birchmeier, W. and Vivier, E. and Guarda, G.
Cell Reports 23
(1): 39-49.
3 April 2018
Lenalidomide regulates CNS autoimmunity by promoting M2 macrophages polarization.
Weng, Q. and Wang, J. and Wang, J. and Wang, J. and Sattar, F. and Zhang, Z. and Zheng, J. and Xu, Z. and Zhao, M. and Liu, X. and Yang, L. and Hao, G. and Fang, L. and Lu, Q.R. and Yang, B. and He, Q.
Cell Death & Disease 9
(2): 251.
14 February 2018
2017
Characterization and structural determination of a new anti-MET function-blocking antibody with binding epitope distinct from the ligand binding domain.
DiCara, D.M. and Chirgadze, D.Y. and Pope, A.R. and Karatt-Vellatt, A. and Winter, A. and Slavny, P. and van den Heuvel, J. and Parthiban, K. and Holland, J. and Packman, L.C. and Mavria, G. and Hoffmann, J. and Birchmeier, W. and Gherardi, E. and McCafferty, J.
Scientific Reports 7
(1): 9000.
21 August 2017
Cancer stem cells regulate cancer-associated fibroblasts via activation of Hedgehog signaling in mammary gland tumors.
Valenti, G. and Quinn, H.M. and Heynen, G.J.J.E. and Lan, L. and Holland, J.D. and Vogel, R. and Wulf-Goldenberg, A. and Birchmeier, W.
Cancer Research 77
(8): 2134-2147.
15 April 2017
UroFors: Konstituierung eines Interessensverbundes fuer Naturwissenschaftler in der urologischen Forschung [UroFors: establishment of an interest group for natural scientists in urological research].
Stope, M.B. and Dansranjavin, T. and Erb, H. and Erdmann, K. and Fendler, A. and Hoelters, S. and Juengel, E. and Nitschke, K. and Salomo, K. and Seidel, P. and Skowron, M.A. and Wach, S. and Becker, C.
Urologe 56
(4): 515-518.
April 2017
2016
The translational potential of microRNAs as biofluid markers of urological tumours.
Fendler, A. and Stephan, C. and Yousef, G.M. and Kristiansen, G. and Jung, K.
Nature Reviews Urology 13
(12): 734-752.
December 2016
New Wnt/β-catenin target genes promote experimental metastasis and migration of colorectal cancer cells through different signals.
Qi, J. and Yu, Y. and Akilli Öztürk, Ö. and Holland, J.D. and Besser, D. and Fritzmann, J. and Wulf-Goldenberg, A. and Eckert, K. and Fichtner, I. and Birchmeier, W.
Gut 65
(10): 1690-1701.
October 2016
RNF4-dependent oncogene activation by protein stabilization.
Thomas, J.J. and Abed, M. and Heuberger, J. and Novak, R. and Zohar, Y. and Beltra-Lopez, A.P. and Trausch-Azar, J.S. and Ilagan, M.X.G. and Benhamou, D. and Dittmar, G. and Kopan, R. and Birchmeier, W. and Schwartz, A.L. and Orian, A.
Cell Reports 16
(12): 3388-3400.
20 September 2016
The A-kinase anchoring protein (AKAP) glycogen synthase kinase 3β interaction protein (GSKIP) regulates β-catenin through its interactions with both protein kinase A (PKA) and GSK3β.
Dema, A. and Schröter, M.F. and Perets, E. and Skroblin, P. and Moutty, M.C. and Deàk, V.A. and Birchmeier, W. and Klussmann, E.
Journal of Biological Chemistry 291
(37): 19618-19630.
9 September 2016
Orchestrating Wnt signalling for metabolic liver zonation.
Birchmeier, W.
Nature Cell Biology 18
(5): 463-465.
May 2016
Effects of silibinin on growth and invasive properties of human ovarian carcinoma cells through suppression of heregulin/HER3 pathway.
Momeny, M. and Ghasemi, R. and Valenti, G. and Miranda, M. and Zekri, A. and Zarrinrad, G. and Javadikooshesh, S. and Yaghmaie, M. and Alimoghaddam, K. and Ghavamzadeh, A. and Ghaffari, S.H.
Tumor Biology 37
(3): 3913-3923.
March 2016
A small-molecule antagonist of the β-catenin/TCF4 interaction blocks the self-renewal of cancer stem cells and suppresses tumorigenesis.
Fang, L. and Zhu, Q. and Neuenschwander, M. and Specker, E. and Wulf-Goldenberg, A. and Weis, W.I. and von Kries, J.P. and Birchmeier, W.
Cancer Research 76
(4): 891-901.
15 February 2016
Diagnostic and prognostic potential of circulating cell-free genomic and mitochondrial DNA fragments in clear cell renal cell carcinoma patients.
Lu, H. and Busch, J. and Jung, M. and Rabenhorst, S. and Ralla, B. and Kilic, E. and Mergemeier, S. and Budach, N. and Fendler, A. and Jung, K.
Clinica Chimica Acta 452
: 109-119.
15 January 2016
Developing antagonists for the Met-HGF/SF protein-protein interaction using a fragment-based approach.
Winter, A. and Sigurdardottir, A.G. and DiCara, D. and Valenti, G. and Blundell, T.L. and Gherardi, E.
Molecular Cancer Therapeutics 15
(1): 3-14.
January 2016
2015
Gab1 and Mapk signaling are essential in the hair cycle and hair follicle stem cell quiescence.
Akilli Öztürk, Ö. and Pakula, H. and Chmielowiec, J. and Qi, J. and Stein, S. and Lan, L. and Sasaki, Y. and Rajewsky, K. and Birchmeier, W.
Cell Reports 13
(3): 561-572.
20 October 2015
Piwi-interacting RNAs as novel prognostic markers in clear cell renal cell carcinomas.
Busch, J. and Ralla, B. and Jung, M. and Wotschofsky, Z. and Trujillo-Arribas, E. and Schwabe, P. and Kilic, E. and Fendler, A. and Jung, K.
Journal of Experimental & Clinical Cancer Research 34
(1): 61.
14 June 2015
Shp2 signaling suppresses senescence in PyMT-induced mammary gland cancer in mice.
Lan, L. and Holland, J.D. and Qi, J. and Grosskopf, S. and Rademann, J. and Vogel, R. and Gyoerffy, B. and Wulf-Goldenberg, A. and Birchmeier, W.
EMBO Journal 34
(11): 1493-1508.
3 June 2015
Molecular signaling mechanisms of axon-glia communication in the peripheral nervous system.
Grigoryan, T. and Birchmeier, W.
BioEssays 37
(5): 502-513.
May 2015
Selective inhibitors of the protein tyrosine phosphatase SHP2 block cellular motility and growth of cancer cells in vitro and in vivo.
Grosskopf, S. and Eckert, C. and Arkona, C. and Radetzki, S. and Böhm, K. and Heinemann, U. and Wolber, G. and von Kries, J.P. and Birchmeier, W. and Rademann, J.
ChemMedChem 10
(5): 815-826.
May 2015
Heregulin-HER3-HER2 signaling promotes matrix metalloproteinase-dependent blood-brain-barrier transendothelial migration of human breast cancer cell lines.
Momeny, M. and Saunus, J.M. and Marturana, F. and McCart Reed, A.E. and Black, D. and Sala, G. and Iacobelli, S. and Holland, J.D. and Yu, D. and Da Silva, L. and Simpson, P.T. and Khanna, K.K. and Chenevix-Trench, G. and Lakhani, S.R.
Oncotarget 6
(6): 3932-3946.
19 February 2015
Global increase of p16INK4a in APC-deficient mouse liver drives clonal growth of p16INK4a negative tumors.
Ueberham, E. and Glöckner, P. and Göhler, C. and Straub, B.K. and Teupser, D. and Schönig, K. and Braeuning, A. and Höhn, A.K. and Jerchow, B. and Birchmeier, W. and Gaunitz, F. and Arendt, T. and Sansom, O. and Gebhardt, R. and Ueberham, U.
Molecular Cancer Research 13
(2): 239-249.
February 2015
2014
Afadin requirement for cytokine expressions in keratinocytes during chemically induced inflammation in mice.
Yoshida, T. and Iwata, T. and Takai, Y. and Birchmeier, W. and Yamato, M. and Okano, T.
Genes to Cells 19
(11): 842-852.
November 2014
The BCL9-2 proto-oncogene governs estrogen receptor alpha expression in breast tumorigenesis.
Zatula, N. and Wiese, M. and Bunzendahl, J. and Birchmeier, W. and Perske, C. and Bleckmann, A. and Brembeck, F.H.
Oncotarget 5
(16): 6770-6787.
30 August 2014
Wnt-Fzd signaling sensitizes peripheral sensory neurons via distinct noncanonical pathways.
Simonetti, M. and Agarwal, N. and Stösser, S. and Bali, K.K. and Karaulanov, E. and Kamble, R. and Pospisilova, B. and Kurejova, M. and Birchmeier, W. and Niehrs, C. and Heppenstall, P. and Kuner, R.
Neuron 83
(1): 104-121.
2 July 2014
Shp2/MAPK signaling controls goblet/paneth cell fate decisions in the intestine.
Heuberger, J. and Kosel, F. and Qi, J. and Grossmann, K.S. and Rajewsky, K. and Birchmeier, W.
Proceedings of the National Academy of Sciences of the United States of America 111
(9): 3472-3477.
4 March 2014
Activation of MAPK overrides the termination of myelin growth and replaces Nrg1/ErbB3 signals during Schwann cell development and myelination.
Sheean, M.E. and McShane, E. and Cheret, C. and Walcher, J. and Müller, T. and Wulf-Goldenberg, A. and Hoelper, S. and Garratt, A.N. and Krüger, M. and Rajewsky, K. and Meijer, D. and Birchmeier, W. and Lewin, G.R. and Selbach, M. and Birchmeier, C.
Genes & Development 28
(3): 290-303.
1 February 2014
2013
Combined Wnt/β-catenin, met, and CXCL12/CXCR4 signals characterize basal breast cancer and predict disease outcome.
Holland, J.D. and Györffy, B. and Vogel, R. and Eckert, K. and Valenti, G. and Fang, L. and Lohneis, P. and Elezkurtaj, S. and Ziebold, U. and Birchmeier, W.
Cell Reports 5
(5): 1214-1227.
12 December 2013
Wnt/Rspondin/β-catenin signals control axonal sorting and lineage progression in Schwann cell development.
Grigoryan, T. and Stein, S. and Qi, J. and Wende, H. and Garratt, A.N. and Nave, K.A. and Birchmeier, C. and Birchmeier, W.
Proceedings of the National Academy of Sciences of the United States of America 110
(45): 18174-18179.
5 November 2013
MicroRNA signature helps distinguish early from late biochemical failure in prostate cancer.
Lichner, Z. and Fendler, A. and Saleh, C. and Nasser, A.N. and Boles, D. and Al-Haddad, S. and Kupchak, P. and Dharsee, M. and Nuin, P.S. and Evans, K.R. and Jung, K. and Stephan, C. and Fleshner, N.E. and Yousef, G.M.
Clinical Chemistry 59
(11): 1595-1603.
November 2013
Loss of epidermal Evi/Wls results in a phenotype resembling psoriasiform dermatitis.
Augustin, I. and Gross, J. and Baumann, D. and Korn, C. and Kerr, G. and Grigoryan, T. and Mauch, C. and Birchmeier, W. and Boutros, M.
Journal of Experimental Medicine 210
(9): 1761-1777.
26 August 2013
Wnt/β-catenin signalling induces MLL to create epigenetic changes in salivary gland tumours.
Wend, P. and Fang, L. and Zhu, Q. and Schipper, J.H. and Loddenkemper, C. and Kosel, F. and Brinkmann, V. and Eckert, K. and Hindersin, S. and Holland, J.D. and Lehr, S. and Kahn, M. and Ziebold, U. and Birchmeier, W.
EMBO Journal 32
(14): 1977-1989.
17 July 2013
Wnt signaling in stem and cancer stem cells.
Holland, J.D. and Klaus, A. and Garratt, A.N. and Birchmeier, W.
Current Opinion in Cell Biology 25
(2): 254-264.
April 2013
2012
Sodium current deficit and arrhythmogenesis in a murine model of plakophilin-2 haploinsufficiency.
Cerrone, M. and Noorman, M. and Lin, X. and Chkourko, H. and Liang, F.X. and van der Nagel, R. and Hund, T. and Birchmeier, W. and Mohler, P. and van Veen, T.A. and van Rijen, H.V. and Delmar, M.
Cardiovascular Research 95
(4): 460-468.
1 September 2012
Specific paucity of unmyelinated C-fibers in cutaneous peripheral nerves of the African naked-mole rat: comparative analysis using six species of bathyergidae.
Smith, E.S.J. and Purfürst, B. and Grigoryan, T. and Park, T.J. and Bennett, N.C. and Lewin, G.R.
Journal of Comparative Neurology 520
(12): 2785-2803.
15 August 2012
Neocortical dendritic complexity is controlled during development by NOMA-GAP-dependent inhibition of Cdc42 and activation of cofilin.
Rosario, M. and Schuster, S. and Juettner, R. and Parthasarathy, S. and Tarabykin, V. and Birchmeier, W.
Genes & Development 26
(15): 1743-1757.
1 August 2012
Wnt/beta-catenin and Bmp signals control distinct sets of transcription factors in cardiac progenitor cells.
Klaus, A. and Mueller, M. and Schulz, H. and Saga, Y. and Martin, J.F. and Birchmeier, W.
Proceedings of the National Academy of Sciences of the United States of America 109
(27): 10921-10926.
3 July 2012
The role of Irf6 in tooth epithelial invagination.
Blackburn, J. and Ohazama, A. and Kawasaki, K. and Otsuka-Tanaka, Y. and Liu, B. and Honda, K. and Rountree, R.B. and Hu, Y. and Kawasaki, M. and Birchmeier, W. and Schmidt-Ullrich, R. and Kinoshita, A. and Schutte, B.C. and Hammond, N.L. and Dixon, M.J. and Sharpe, P.T.
Developmental Biology 365
(1): 61-70.
1 May 2012
The miRNA-kallikrein axis of interaction: a new dimension in the pathogenesis of prostate cancer.
White, N.M.A. and Youssef, Y.M. and Fendler, A. and Stephan, C. and Jung, K. and Yousef, G.M.
Biological Chemistry 393
(5): 379-389.
May 2012
Targeting MET in cancer: rationale and progress.
Gherardi, E. and Birchmeier, W. and Birchmeier, C. and Woude, G.V.
Nature Reviews Cancer 12
(2): 89-103.
February 2012
Where do you come from; where do you go? Pluripotency, differentiation and malfunction of stem cells.
Spagnoli, F.M. and Besser, D. and Benitah, S.A.
EMBO Reports 13
(1): 9-11.
January 2012
2011
The tyrosine phosphatase Shp2 acts downstream of GDNF/Ret in branching morphogenesis of the developing mouse kidney.
Willecke, R. and Heuberger, J. and Grossmann, K. and Michos, O. and Schmidt-Ott, K. and Walentin, K. and Costantini, F. and Birchmeier, W.
Developmental Biology 360
(2): 310-307.
15 December 2011
BCL9-2 promotes early stages of intestinal tumor progression.
Brembeck, F.H. and Wiese, M. and Zatula, N. and Grigoryan, T. and Dai, Y. and Fritzmann, J. and Birchmeier, W.
Gastroenterology 141
(4): 1359-1370.
October 2011
Stem cells: Orphan receptors find a home.
Birchmeier, W.
Nature 476
(7360): 287-288.
18 August 2011
E-cadherin is crucial for embryonic stem cell pluripotency and can replace OCT4 during somatic cell reprogramming.
Redmer, T. and Diecke, S. and Grigoryan, T. and Quiroga-Negreira, A. and Birchmeier, W. and Besser, D.
EMBO Reports 12
(7): 720-726.
1 July 2011
Epicatechin gallate and catechin gallate are superior to epigallocatechin gallate in growth suppression and anti-inflammatory activities in pancreatic tumor cells.
Kuerbitz, C. and Heise, D. and Redmer, T. and Goumas, F. and Arlt, A. and Lemke, J. and Rimbach, G. and Kalthoff, H. and Trauzold, A.
Cancer Science 102
(4): 728-734.
April 2011
2010
Identification of Y-box binding protein 1 as a core regulator of MEK/ERK pathway-dependent gene signatures in colorectal cancer cells.
Juerchott, K. and Kuban, R.J. and Krech, T. and Blüthgen, N. and Stein, U. and Walther, W. and Friese, C. and Kielbasa, S.M. and Ungethuem, U. and Lund, P. and Knoesel, T. and Kemmner, W. and Morkel, M. and Fritzmann, J. and Schlag, P.M. and Birchmeier, W. and Krueger, T. and Sperling, S. and Sers, C. and Royer, H.D. and Herzel, H. and Schaefer, R.
PLoS Genetics 6
(12): e1001231.
2 December 2010
Wnt signaling in stem and cancer stem cells.
Wend, P. and Holland, J.D. and Ziebold, U. and Birchmeier, W.
Seminars in Cell & Developmental Biology 21
(8): 855-863.
October 2010
Bone morphogenetic protein-7 release from endogenous neural precursor cells suppresses the tumourigenicity of stem-like glioblastoma cells.
Chirasani, S.R. and Sternjak, A. and Wend, P. and Momma, S. and Campos, B. and Herrmann, I.M. and Graf, D. and Mitsiadis, T. and Herold-Mende, C. and Besser, D. and Synowitz, M. and Kettenmann, H. and Glass, R.
Brain 133
(Pt 7): 1961-1972.
July 2010
Two isoforms of human RNA polymerase III with specific functions in cell growth and transformation.
Haurie, V. and Durrieu-Gaillard, S. and Dumay-Odelot, H. and Da Silva, D. and Rey, C. and Prochazkova, M. and Roeder, R.G. and Besser, D. and Teichmann, M.
Proceedings of the National Academy of Sciences of the United States of America 107
(9): 4176-4181.
2 March 2010
Interplay of cadherin-mediated cell adhesion and canonical wnt signaling.
Heuberger, J. and Birchmeier, W.
Cold Spring Harbor Perspectives in Biology 2
(2): a002915.
February 2010
Role of Epiprofin, a zinc-finger transcription factor, in limb development.
Talamillo, A. and Delgado, I. and Nakamura, T. and de-Vega, S. and Yoshitomi, Y. and Unda, F. and Birchmeier, W. and Yamada, Y. and Ros, M.A.
Developmental Biology 337
(2): 363-374.
15 January 2010
The tyrosine phosphatase Shp2 in development and cancer.
Grossmann, K.S. and Rosario, M. and Birchmeier, C. and Birchmeier, W.
Advances in Cancer Research 106
: 53-89.
2010
2009
The LIM domain protein Wtip interacts with the receptor tyrosine kinase Ror2 and inhibits canonical Wnt signalling.
Wijk, N.V. and Witte, F. and Feike, A.C. and Schambony, A. and Birchmeier, W. and Mundlos, S. and Stricker, S.
Biochemical and Biophysical Research Communications 390
(2): 211-216.
11 December 2009
The tyrosine phosphatase Shp2 (PTPN11) directs neuregulin-1/ErbB signaling throughout schwann cell development.
Grossmann, K.S. and Wende, H. and Paul, F.E. and Cheret, C. and Garratt, A.N. and Zurborg, S. and Feinberg, K. and Besser, D. and Schulz, H. and Peles, E. and Selbach, M. and Birchmeier, W. and Birchmeier, C.
Proceedings of the National Academy of Sciences of the United States of America 106
(39): 16704-16709.
29 September 2009
Reciprocal requirements for EDA/EDAR/NF-κB and Wnt/β-catenin signaling pathways in hair follicle induction.
Zhang, Y. and Tomann, P. and Andl, T. and Gallant, N.M. and Huelsken, J. and Jerchow, B. and Birchmeier, W. and Paus, R. and Piccolo, S. and Mikkola, M.L. and Morrisey, E.E. and Overbeek, P.A. and Scheidereit, C. and Millar, S.E. and Schmidt-Ullrich, R.
Developmental Cell 17
(1): 49-61.
21 July 2009
A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential.
Fritzmann, J. and Morkel, M. and Besser, D. and Budczies, J. and Kosel, F. and Brembeck, F.H. and Stein, U. and Fichtner, I. and Schlag, P.M. and Birchmeier, W.
Gastroenterology 137
(11): 165-175.
July 2009
Developmental signaling in myocardial progenitor cells: A comprehensive view of Bmp- and Wnt/beta-catenin signaling.
Klaus, A. and Birchmeier, W.
Pediatric Cardiology 30
(5): 609-616.
July 2009
Embryonic hair follicle fate change by augmented β-catenin through Shh and Bmp signaling.
Suzuki, K. and Yamaguchi, Y. and Villacorte, M. and Mihara, K. and Akiyama, M. and Shimizu, H. and Taketo, M.M. and Nakagata, N. and Tsukiyama, T. and Yamaguchi, T.P. and Birchmeier, W. and Kato, S. and Yamada, G.
Development 136
(3): 367-372.
February 2009
MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis.
Stein, U. and Walther, W. and Arlt, F. and Schwabe, H. and Smith, J. and Fichtner, I. and Birchmeier, W. and Schlag, P.M.
Nature Medicine 15
(1): 59-67.
January 2009
2008
Homogeneity and persistence of transgene expression by omitting antibiotic selection in cell line isolation.
Kaufman, W.L. and Kocman, I. and Agrawal, V. and Rahn, H.P. and Besser, D. and Gossen, M.
Nucleic Acids Research 36
(17): e111.
October 2008
Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice.
Grigoryan, T. and Wend, P. and Klaus, A. and Birchmeier, W.
Genes & Development 22
(17): 2308-2341.
1 September 2008
FGF2 signaling in mouse embryonic fibroblasts is crucial for self-renewal of embryonic stem cells.
Diecke, S. and Quiroga-Negreira, A. and Redmer, T. and Besser, D.
Cells Tissues Organs 188
(1-2): 52-61.
July 2008
Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking.
Hellmuth, K. and Grosskopf, S. and Lum, C.T. and Wuertele, M. and Roeder, N. and von Kries, J.P. and Rosario, M. and Rademann, J. and Birchmeier, W.
Proceedings of the National Academy of Sciences of the United States of America 105
(20): 7275-7280.
20 May 2008
Wnt signalling and its impact on development and cancer.
Klaus, A. and Birchmeier, W.
Nature Reviews Cancer 8
(5): 387-398.
May 2008
Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling.
Malanchi, I. and Peinado, H. and Kassen, D. and Hussenet, T. and Metzger, D. and Chambon, P. and Huber, M. and Hohl, D. and Cano, A. and Birchmeier, W. and Huelsken, J.
Nature 452
(7187): 650-653.
3 April 2008
Sustained epithelial beta-catenin activity induces precocious hair development but disrupts hair follicle down-growth and hair shaft formation.
Naerhi, K. and Jaervinen, E. and Birchmeier, W. and Taketo, M.M. and Mikkola, M.L. and Thesleff, I.
Development 135
(6): 1019-1028.
March 2008
Long-term, multilineage hematopoiesis occurs in the combined absence of beta-catenin and gamma-catenin.
Jeannet, G. and Scheller, M. and Scarpellino, L. and Duboux, S. and Gardiol, N. and Back, J. and Kuttler, F. and Malanchi, I. and Birchmeier, W. and Leutz, A. and Huelsken, J. and Held, W.
Blood 111
(1): 142-149.
1 January 2008
2007
Distinct roles of Wnt/beta-catenin and Bmp signaling during early cardiogenesis.
Klaus, A. and Saga, Y. and Taketo, M.M. and Tzahor, E. and Birchmeier, W.
Proceedings of the National Academy of Sciences of the United States of America 104
(47): 18531-18536.
20 November 2007
Distinct requirements for Gab1 in Met and EGF receptor signaling in vivo.
Schaeper, U. and Vogel, R. and Chmielowiec, J. and Huelsken, J. and Rosario, M. and Birchmeier, W.
Proceedings of the National Academy of Sciences of the United States of America 104
(39): 15376-15381.
25 September 2007
The neurite outgrowth multiadaptor RhoGAP, NOMA-GAP, regulates neurite extension through SHP2 and Cdc42.
Rosario, M. and Franke, R. and Bednarski, C. and Birchmeier, W.
Journal of Cell Biology 178
(3): 503-516.
30 July 2007
Mutations of the Wnt antagonist AXIN2 (Conductin) result in TCF-dependent transcription in medulloblastomas.
Koch, A. and Hrychyk, A. and Hartmann, W. and Waha, A. and Mikeska, T. and Waha, A. and Schueller, U. and Soerensen, N. and Berthold, F. and Goodyer, C.G. and Wiestler, O.D. and Birchmeier, W. and Behrens, J. and Pietsch, T.
International Journal of Cancer 121
(2): 284-291.
15 July 2007
Beta-catenin downregulation is required for adaptive cardiac remodeling.
Baurand, A. and Zelarayan, L. and Betney, R. and Gehrke, C. and Dunger, S. and Noack, C. and Busjahn, A. and Huelsken, J. and Taketo, M.M. and Birchmeier, W. and Dietz, R. and Bergmann, M.W.
Circulation Research 100
(9): 1353-1362.
11 May 2007
The transcriptional repressor Glis2 is a novel binding partner for p120 catenin.
Hosking, C.R. and Ulloa, F. and Hogan, C. and Ferber, E. and Figueroa, A. and Gevaert, K. and Birchmeier, W. and Briscoe, J. and Fujita, Y.
Molecular Biology of the Cell 18
(5): 1918-1927.
1 May 2007
c-Met is essential for wound healing in the skin.
Chmielowiec, J. and Borowiak, M. and Morkel, M. and Stradal, T. and Munz, B. and Werner, S. and Wehland, J. and Birchmeier, C. and Birchmeier, W.
Journal of Cell Biology 177
(1): 151-162.
9 April 2007
Beta-catenin regulates P-cadherin expression in mammary basal epithelial cells.
Faraldo, M.M. and Teuliere, J. and Deugnier, M.A. and Birchmeier, W. and Huelsken, J. and Thiery, J.P. and Cano, A. and Glukhova, M.A.
FEBS Letters 581
(5): 831-836.
6 March 2007
Bmp and Wnt/beta-catenin signals control expression of the transcription factor Olig3 and the specification of spinal cord neurons.
Zechner, D. and Muller, T. and Wende, H. and Walther, I. and Taketo, M.M. and Crenshaw, E.B. and Treier, M. and Birchmeier, W. and Birchmeier, C.
Developmental Biology 303
(1): 181-190.
1 March 2007
2006
Shp-2 inhibitors, pharmaceutical compositions comprising them and their use for treating phosphatase-mediated diseases [Shp-2-Inhibitoren, Arzneimittel, die sie enthalten sowie deren Verwendung zur Behandlung von Phosphatasen-vermittelten Krankheiten].
Hellmuth, K. and Birchmeier, W.
EP1728790 ; WO06128909.
6 December 2006
Continuous tooth generation in mouse is induced by activated epithelial Wnt/β-catenin signaling.
Jaervinen, E. and Salazar-Ciudad, I. and Birchmeier, W. and Taketo, M.M. and Jernvall, J. and Thesleff, I.
Proceedings of the National Academy of Sciences of the United States of America 103
(49): 18627-18632.
5 December 2006
The metastasis-associated gene S100A4 is a novel target of beta-catenin/T-cell factor (TCF) signaling in colon cancer.
Stein, U. and Arlt, F. and Walther, W. and Smith, J. and Waldman, T. and Harris, E.D. and Mertins, S.D. and Heizmann, C.W. and Allard, D. and Birchmeier, W. and Schlag, P.M. and Shoemaker, R.H.
Gastroenterology 131
(5): 1486-1500.
November 2006
Diversin regulates heart formation and gastrulation movements in development.
Moeller, H. and Jenny, A. and Schaeffer, H.J. and Schwarz-Romond, T. and Mlodzik, M. and Hammerschmidt, M. and Birchmeier, W.
Proceedings of the National Academy of Sciences of the United States of America 103
(43): 15900-15905.
24 October 2006
Hematopoietic stem cell and multilineage defects generated by constitutive beta-catenin activation.
Scheller, M. and Huelsken, J. and Rosenbauer, F. and Taketo, M.M. and Birchmeier, W. and Tenen, D.G. and Leutz, A.
Nature Immunology 7
(10): 1037-1047.
October 2006
Aberrant Wnt/beta-catenin signaling can induce chromosomal instability in colon cancer.
Hadjihannas, M.V. and Brueckner, M. and Jerchow, B. and Birchmeier, W. and Dietmaier, W. and Behrens, J.
Proceedings of the National Academy of Sciences of the United States of America 103
(28): 10747-10752.
11 July 2006
Arrhythmogenic right ventricular cardiomyopathy: moving toward mechanism.
MacRae, C.A. and Birchmeier, W. and Thierfelder, L.
Journal of Clinical Investigation 116
(7): 1825-1828.
July 2006
Multiple roles of mesenchymal beta-catenin during murine limb patterning.
Hill, T.P. and Taketo, M.M. and Birchmeier, W. and Hartmann, C.
Development 133
(7): 1219-1229.
1 April 2006
Balancing cell adhesion and Wnt signaling, the key role of beta-catenin.
Brembeck, F.H. and Rosario, M. and Birchmeier, W.
Current Opinion in Genetics & Development 16
(1): 51-59.
February 2006
Limb development.
Soshnikova, N. and Birchmeier, W.
In:
Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine ; Vol. 1.
Springer, Berlin [u.a.], 976-981.
ISBN 3-540-44244-8
2006
Tyrosine kinases.
Schaeper, U. and Grossmann, K.S.
In:
Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine ; Vol. 2.
Springer, Berlin [u.a.], 1951-1959.
ISBN 3-540-44244-8
2006
2005
Expression of multidrug resistance proteins (Mrps) in astrocytes of the mouse brain: a single cell rt-PCR study.
Hirrlinger, J. and Moeller, H. and Kirchhoff, F. and Dringen, R.
Neurochemical Research 30
(10): 1237-1244.
1 October 2005
A human protein-protein interaction network: a resource for annotating the proteome.
Stelzl, U. and Worm, U. and Lalowski, M. and Haenig, C. and Brembeck, F.H. and Goehler, H. and Stroedicke, M. and Zenkner, M. and Schoenherr, A. and Koeppen, S. and Timm, J. and Mintzlaff, S. and Abraham, C. and Bock, N. and Kietzmann, S. and Goedde, A. and Toksoez, E. and Droege, A. and Krobitsch, S. and Korn, B. and Birchmeier, W. and Lehrach, H. and Wanker, E.E.
Cell 122
(6): 957-968.
23 September 2005
The MEK1 scaffolding protein MP1 regulates cell spreading by integrating PAK1 and Rho signals.
Pullikuth, A. and McKinnon, E. and Schaeffer, H.J. and Catling, A.D.
Molecular and Cellular Biology 25
(12): 5119-5133.
1 June 2005
Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes.
Hill, T.P. and Spaeter, D. and Taketo, M.M. and Birchmeier, W. and Hartmann, C.
Developmental Cell 8
(5): 727-738.
1 May 2005
Cell adhesion and signal transduction in cancer.
Birchmeier, W.
EMBO Reports 6
(5): 413-417.
1 January 2005
HGF/SF c-Met signaling in the epithelial-mesenchymal transition and migration of muscle progenitor cells.
Schaeper, U. and Birchmeier, W.
In:
Cell Migration in Development and Disease.
Wiley-VCH, Weinheim, 191-204.
ISBN 3-527-30587-4
1 January 2005
MEK Partner 1 (MP1): Regulation of oligomerization in MAP kinase signaling.
Sharma, C. and Vomastek, T. and Tarcsafalvi, A. and Catling, A.D. and Schaeffer, H.J. and Eblen, S.T. and Weber, M.J.
Journal of Cellular Biochemistry 94
(4): 708-719.
1 January 2005
The role of Axin2 in calvarial morphogenesis and craniosynostosis.
Yu, H.M. and Jerchow, B. and Sheu, T.J. and Liu, B. and Costantini, F. and Puzas, J.E. and Birchmeier, W. and Hsu, W.
Development 132
(8): 1995-2005.
1 January 2005
Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung.
Shu, W. and Guttentag, S. and Wang, Z. and Andl, T. and Ballard, P. and Lu, M.M. and Piccolo, S. and Birchmeier, W. and Whitsett, J.A. and Millar, S.E. and Morrisey, E.E.
Developmental Biology 283
(1): 226-239.
1 January 2005
2004
The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells.
Schuetz, G. and Rosario, M. and Grimm, J. and Boeckers, T.M. and Gundelfinger, E.D. and Birchmeier, W.
Journal of Cell Biology 167
(5): 945-952.
6 December 2004
Mutations in the desmosomal protein plakophilin-2 are common in arrhythmogenic right ventricular cardiomyopathy.
Gerull, B. and Heuser, A. and Wichter, T. and Paul, M. and Basson, C.T. and McDermott, D.A. and Lerman, B.B. and Markowitz, S.M. and Ellinor, P.T. and MacRae, C.A. and Peters, S. and Grossmann, K.S. and Drenckhahn, J. and Michely, B. and Sasse-Klaassen, S. and Birchmeier, W. and Dietz, R. and Breithardt, G. and Schulze-Bahr, E. and Thierfelder, L.
Nature Genetics 36
(11): 1162-1164.
November 2004
Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation.
Grossmann, K.S. and Grund, C. and Huelsken, J. and Behrend, M. and Erdmann, B. and Franke, W.W. and Birchmeier, W.
Journal of Cell Biology 167
(1): 149-160.
11 October 2004
beta-catenin-dependent and -independent effects of deltaN-plakoglobin on epidermal growth and differentiation.
Teuliere, J. and Faraldo, M.M. and Shtutman, M. and Birchmeier, W. and Huelsken, J. and Thiery, J.P. and Glukhova, M.A.
Molecular and Cellular Biology 24
(19): 8649-8661.
1 October 2004
Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions.
Brembeck, F.H. and Schwarz-Romond, T. and Bakkers, J. and Wilhelm, S. and Hammerschmidt, M. and Birchmeier, W.
Genes & Development 18
(18): 2225-2230.
15 September 2004
Making tubes: Step by step.
Rosario, M. and Birchmeier, W.
Developmental Cell 7
(1): 3-5.
1 July 2004
Expression of nodal, lefty-A, and lefty-B in undifferentiated human embryonic stem cells requires activation of Smad2/3.
Besser, D.
Journal of Biological Chemistry 279
(43): 45076-45084.
1 January 2004
Mutations and elevated transcriptional activity of conductin (AXIN2) in hepatoblastomas.
Koch, A. and Weber, N. and Waha, A. and Hartmann, W. and Denkhaus, D. and Behrens, J. and Birchmeier, W. and von Schweinitz, D. and Pietsch, T.
Journal of Pathology 204
(5): 546-554.
1 January 2004
Rap1 regulates the formation of E-cadherin-based cell-cell contacts.
Hogan, C. and Serpente, N. and Cogram, P. and Hosking, C.R. and Bialucha, C.U. and Feller, S.M. and Braga, V.M.M. and Birchmeier, W. and Fujita, Y.
Molecular and Cellular Biology 24
(15): 6690-6700.
1 January 2004
The docking protein Gab1 is an essential component of an indirect mechanism for fibroblast growth factor stimulation of the phosphatidylinositol 3-kinase/Akt antiapoptotic pathway.
Lamothe, B. and Yamada, M. and Schaeper, U. and Birchmeier, W. and Lax, I. and Schlessinger, J.
Molecular and Cellular Biology 24
(13): 5657-5666.
1 January 2004
Tyrosine kinase receptor RON functions downstream of the erythropoietin receptor to induce expansion of erythroid progenitors.
van den Akker, E. and van Dijk, T. and Parren-van Amelsvoort, M. and Grossmann, K.S. and Schaeper, U. and Toney-Earley, K. and Waltz, S.E. and Loewenberg, B. and von Lindern, M.
Blood 103
(12): 4457-4465.
1 January 2004
Deciphering the function of signaling pathways by tissue specific gene modification in mice.
Zechner, D. and Soshnikova, N. and Birchmeier, W.
Zellbiologie Aktuell 30
(1): 6-8.
January 2004
2003
Met, metastasis, motility and more.
Birchmeier, C. and Birchmeier, W. and Gherardi, E. and Vande Woude, G.F.
Nature Reviews Molecular Cell Biology 4
(12): 915-925.
December 2003
Role of β-catenin in synaptic vesicle localization and presynaptic assembly.
Bamji, S.X. and Shimazu, K. and Kimes, N. and Huelsken, J. and Birchmeier, W. and Lu, B. and Reichardt, L.F.
Neuron 40
(4): 719-731.
November 2003
β-catenin is required for specification of proximal/distal cell fate during lung morphogenesis.
Mucenski, M.L. and Wert, S.E. and Nation, J.M. and Loudy, D.E. and Huelsken, J. and Birchmeier, W. and Morrisey, E.E. and Whitsett, J.A.
Journal of Biological Chemistry 278
(41): 40231-40238.
10 October 2003
beta-catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system.
Zechner, D. and Fujita, Y. and Huelsken, J. and Mueller, T. and Walther, I. and Taketo, M.M. and Crenshaw, E.B. and Birchmeier, W. and Birchmeier, C.
Developmental Biology 258
(2): 406-418.
15 June 2003
How to make tubes: signaling by the Met receptor tyrosine kinase.
Rosario, M. and Birchmeier, W.
Trends in Cell Biology 13
(6): 328-335.
June 2003
Genetische Analyse von Conductin durch zielgerichtete Mutagenese in der Maus.
Jerchow, B.
UNSPECIFIED thesis, UNSPECIFIED.
6 May 2003
Helicobacter pylori CagA protein targets the c-Met receptor and enhances the motogenic response.
Churin, Y. and Al Ghoul, L. and Kepp, O. and Meyer, T.E. and Birchmeier, W. and Naumann, M.
Journal of Cell Biology 161
(2): 249-255.
28 April 2003
Deletion of beta-catenin impairs T cell development.
Xu, Y. and Banerjee, D. and Huelsken, J. and Birchmeier, W. and Sen, J.M.
Nature Immunology 4
(12): 1177-1182.
1 January 2003
Genetic interaction between Wnt/β-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb.
Soshnikova, N. and Zechner, D. and Huelsken, J. and Mishina, Y. and Behringer, R.R. and Taketo, M.M. and Crenshaw, E.B. and Birchmeier, W.
Genes & Development 17
(16): 1963-1968.
1 January 2003
β-Catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation.
Morkel, M. and Huelsken, J. and Wakamiya, M. and Ding, J. and van de Wetering, M. and Clevers, H. and Taketo, M.M. and Behringer, R.R. and Shen, M.M. and Birchmeier, W.
Development 130
(25): 6283-6294.
1 January 2003
2002
The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling.
Schwarz-Romond, T. and Asbrand, C. and Bakkers, J. and Kuehl, M. and Schaeffer, H.J. and Huelsken, J. and Behrens, J. and Hammerschmidt, M. and Birchmeier, W.
Genes & Development 16
(16): 2073-2084.
15 August 2002
Selection of multipotent stem cells during morphogenesis of small intestinal crypts of Lieberkuehn is perturbed by stimulation of Lef-1/β-catenin signaling.
Wong, M.H. and Huelsken, J. and Birchmeier, W. and Gordon, J.I.
Journal of Biological Chemistry 277
(18): 15843-15850.
3 May 2002
Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex.
Fujita, Y. and Krause, G. and Scheffner, M. and Zechner, D. and Leddy, H.E.M. and Behrens, J. and Sommer, T. and Birchmeier, W.
Nature Cell Biology 4
(3): 222-231.
1 March 2002
Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors.
Lustig, B. and Jerchow, B. and Sachs, M. and Weiler, S. and Pietsch, T. and Karsten, U. and van de Wetering, M. and Clevers, H. and Schlag, P.M. and Birchmeier, W. and Behrens, J.
Molecular and Cellular Biology 22
(4): 1184-1193.
1 February 2002
Expression of deltaNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours.
Niemann, C. and Owens, D.M. and Huelsken, J. and Birchmeier, W. and Watt, F.M.
Development 129
: 95-109.
1 January 2002
The impact of c-met/scatter factor receptor on dendritic cell migration.
Kurz, S.M. and Diebold, S.S. and Hieronymus, T. and Gust, T.C. and Bartunek, P. and Sachs, M. and Birchmeier, W. and Zenke, M.
European Journal of Immunology 32
(7): 1832-1838.
1 January 2002
2001
New aspects of Wnt signaling pathways in higher vertebrates.
Huelsken, J. and Birchmeier, W.
Current Opinion in Genetics & Development 11
(5): 547-553.
1 October 2001
Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation.
Grimm, J. and Sachs, M. and Britsch, S. and Di Cesare, S. and Schwarz-Romond, T. and Birchmeier, W.
Journal of Cell Biology 154
(2): 345-354.
23 July 2001
beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin.
Huelsken, J. and Vogel, R. and Erdmann, B. and Cotsarelis, G. and Birchmeier, W.
Cell 105
(4): 533-545.
18 May 2001
Mittel zur Therapie von menschlichen Erkrankungen, insbesondere fuer die Therapie von Tumoren wie Kolonkarzinomen und Melanomen oder zur Geweberegeneration und Foerderung des Haarwuchses [Agents for treating human diseases, especially for treating tumors such as colonic cancers and melanomas or for regenerating tissue and promoting hair growth].
Birchmeier, W. and Kries, J.P.
DE19944404A1 ; EP1214345 ; WO0119353.
22 March 2001
Negative regulation of Ros receptor tyrosine kinase signaling: An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1.
Keilhack, H. and Mueller, M. and Boehmer, S.A. and Frank, C. and Weidner, K.M. and Birchmeier, W. and Ligensa, T. and Berndt, A. and Kosmehl, H. and Gunther, B. and Mueller, T. and Birchmeier, C. and Boehmer, F.D.
Journal of Cell Biology 152
(2): 325-334.
22 January 2001
Deletions of AXIN1, a component of the WNT/wingless pathway, in sporadic medulloblastomas.
Dahmen, R.P. and Koch, A. and Denkhaus, D. and Tonn, J.C. and Soerensen, N. and Berthold, F. and Behrens, J. and Birchmeier, W. and Wiestler, O.D. and Pietsch, T.
Cancer Research 61
: 7039-7043.
1 January 2001
Requirement of NF-kappaB/Rel for the development of hair follicles and other epidermal appendices.
Schmidt-Ullrich, R. and Aebischer, T. and Huelsken, J. and Birchmeier, W. and Klemm, U. and Scheidereit, C.
Development 128
(19): 3843-3853.
1 January 2001
The C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motif.
Lewitzky, M. and Kardinal, C. and Gehring, N.H. and Schmidt, E.K. and Konkol, B. and Eulitz, M. and Birchmeier, W. and Schaeper, U. and Feller, S.M.
Oncogene 20
(9): 1052-1062.
1 January 2001
2000
Cytochrome P450-dependent renal arachidonic acid metabolism in desoxycorticosterone acetate-salt hypertensive mice.
Honeck, H. and Gross, V. and Erdmann, B. and Kaergel, E. and Neunaber, R. and Milia, A.F. and Schneider, W. and Luft, F.C. and Schunck, W.H.
Hypertension 36
: 610-616.
1 October 2000
E-cadherin and adenomatous polyposis coli mutations are synergistic in intestinal tumor initiation in mice.
Smits, R. and Ruiz, P. and Diaz-Cano, S. and Luz, A. and Jagmohan-Changur, S. and Breukel, C. and Birchmeier, C. and Birchmeier, W. and Fodde, R.
Gastroenterology 119
(4): 1045-1053.
1 October 2000
Conductinprotein und verwandtes Mittel zur Diagnose und zur Therapie von Tumorerkrankungen [Conductine protein and a related agent for diagnosing and treating tumor illnesses].
Behrens, J. and Birchmeier, W.
EP1029047 ; WO9911780.
28 September 2000
Essential role of Gab1 for signaling by the c-Met receptor in vivo.
Sachs, M. and Brohmann, H. and Zechner, D. and Mueller, T. and Huelsken, J. and Walther, I. and Schaeper, U. and Birchmeier, C. and Birchmeier, W.
Journal of Cell Biology 150
(6): 1375-1384.
18 September 2000
Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses.
Schaeper, U. and Gehring, N.H. and Fuchs, K.P. and Sachs, M. and Kempkes, B. and Birchmeier, W.
Journal of Cell Biology 149
(7): 1419-1432.
26 June 2000
Control of beta-catenin signaling in tumor development.
Behrens, J.
Annals of the New York Academy of Sciences 910
: 21-35.
June 2000
Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL.
Sakkab, D. and Lewitzky, M. and Posern, G. and Schaeper, U. and Sachs, M. and Birchmeier, W. and Feller, S.M.
Journal of Biological Chemistry 275
(15): 10772-10778.
14 April 2000
HGF polypeptides and their use in therapy [HGF Polypeptide und deren therapeutische Verwendungen].
Gherardi, E. and Birchmeier, W. and Hartmann, G.
EP0981620 ; DE69821930T2.
6 April 2000
Requirement for beta-catenin in anterior-posterior axis formation in mice.
Huelsken, J. and Vogel, R. and Brinkmann, V. and Erdmann, B. and Birchmeier, C. and Birchmeier, W.
Journal of Cell Biology 148
(3): 567-578.
7 February 2000
Hepatocyte growth factor and neuregulin in mammary gland cell morphogenesis.
Niemann, C. and Brinkmann, V. and Birchmeier, W.
Advances in Experimental Medicine and Biology 480
: 9-18.
1 January 2000
Hot spots in beta-catenin for interactions with LEF-1, conductin and APC.
von Kries, J.P. and Winbeck, G. and Asbrand, C. and Schwarz-Romond, T. and Sochnikova, N. and Dell'Oro, A. and Behrens, J. and Birchmeier, W.
Nature Structural Biology 7
: 800-807.
1 January 2000
1999
Differential cross-talk of estrogen and growth factor receptors in two human mammary tumor cell lines.
Lichtner, R.B. and Parczyk, K. and Birchmeier, W. and Schneider, M.R.
Journal of Steroid Biochemistry and Molecular Biology 71
(5-6): 181-189.
31 December 1999
Mittel zur Therapie von menschlichen Erkrankungen, ausgehend von b-Catenin, seine Herstellung und seine Verwendung.
Birchmeier, W. and Kries, J.P.
DE19909251A1 ; EP1054899 ; US7,067,474.
26 August 1999
Tumour-associated E-cadherin mutations alter cellular morphology, decrease cellular adhesion and increase cellular motility.
Handschuh, G. and Candidus, S. and Luber, B. and Reich, U. and Schott, C. and Oswald, S. and Becke, H. and Hutzler, P. and Birchmeier, W. and Hoefler, H. and Becker, K.F.
Oncogene 18
: 4301-4312.
29 July 1999
Mittel zur Diagnose und zur Therapie von Tumorerkrankungen.
Behrens, J. and Birchmeier, W.
DE19840875A1.
12 May 1999
Hot papers in cell biology - J. Behrens, J.P. von Kries, M. Kuehl, L. Bruhn, D. Wedlich, R. Grosschedl, W. Birchmeier: "Functional interaction of beta-catenin with the transcription factor LEF-1" - Comments by Walter Birchmeier.
Birchmeier, W.
Scientist 13(8)
: 15.
12 April 1999
10. Tyrosine kinase receptors as driving forces for growth, motility and differentiation of epithelial cells.
Birchmeier, W. and Birchmeier, C. and Brinkmann, V. and Niemann, C.
In:
Epithelial Morphogenesis in Development and Disease.
Cell Adhesion and Communication
.
Harwood Acad. Publ., Amsterdam [u.a.], 217-231.
1 January 1999
Epithelial Morphogenesis in Development and Disease.
Birchmeier, W. and Birchmeier, C.
Cell Adhesion and Communication
.
Harwood Acad. Publ., Amsterdam [u.a.].
1 January 1999
Plakoglobin is essential for myocardial compliance but dispensable for myofibril insertion into adherens junctions.
Isac, C.M. and Ruiz, P. and Pfitzmaier, B. and Haase, H. and Birchmeier, W. and Morano, I.
Journal of Cellular Biochemistry 72
(1): 8-15.
1 January 1999
Immunohistological analysis of E-cadherin, alpha-, beta- and gamma-catenin expression in colorectal cancer: Implications for cell adhesion and signaling.
Ghadimi, B.M. and Behrens, J. and Hoffmann, I. and Haensch, W. and Birchmeier, W. and Schlag, P.M.
European Journal of Cancer 35
(1): 60-65.
January 1999
Introduction.
Birchmeier, W.
In:
Guidebook to the Extracellular Matrix, Anchor, and Adhesion Proteins.
Oxford University Press, New York, 121-125.
1999
1998
Reconstitution of mammary gland development in vitro: Requirement of c-met and c-erbB2 signaling for branching and alveolar morphogenesis.
Niemann, C. and Brinkmann, V. and Spitzer, E. and Hartmann, G. and Sachs, M. and Naundorf, H. and Birchmeier, W.
Journal of Cell Biology 143
(2): 533-545.
19 October 1998
Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta.
Behrens, J. and Jerchow, B.A. and Wuertele, M. and Grimm, J. and Asbrand, C. and Wirtz, R. and Kuehl, M. and Wedlich, D. and Birchmeier, W.
Science 280
(5363): 596-599.
24 April 1998
The plakoglobin knock-out mouse: A paradigm for the molecular analysis of cardiac cell junction formation.
Ruiz, P. and Birchmeier, W.
Trends in Cardiovascular Medicine 8
(3): 97-101.
April 1998
Engineered mutants of HGF/SF with reduced binding to heparan sulphate proteoglycans, decreased clearance and enhanced activity in vivo.
Hartmann, G. and Prospero, T. and Brinkmann, V. and Ozcelik, O. and Winter, G. and Hepple, J. and Batley, S. and Bladt, F. and Sachs, M. and Birchmeier, C. and Birchmeier, W. and Gherardi, E.
Current Biology 8
(3): 125-134.
29 January 1998
C-met activation is necessary but not sufficient for liver colonization by B16 murine melanoma cells.
Lin, S. and Rusciano, D. and Lorenzoni, P. and Hartmann, G. and Birchmeier, W. and Giordano, S. and Comoglio, P. and Burger, M.M.
Clinical and Experimental Metastasis 16
: 253-265.
1 January 1998
E-Cadherin in human brain tumours: loss of immunoreactivity in malignant meningiomas.
Schwechheimer, K. and Zhou, L. and Birchmeier, W.
Virchows Archiv 432
: 163-167.
1 January 1998
Role of morphogenetic factors in metastasis of mammary carcinoma cells.
Meiners, S. and Brinkmann, V. and Naundorf, H. and Birchmeier, W.
Oncogene 16
: 9-20.
1 January 1998
The spread and uptake pattern of intracerebrally administered oligonucleotides in nerve and glial cell populations of the rat brain.
Sommer, W. and Cui, X. and Erdmann, B. and Wiklund, L. and Bricca, G. and Heilig, M. and Fuxe, K.
Antisense and Nucleic Acid Drug Development 8
: 75-85.
1 January 1998
Functional involvement of CD44, a family of cell adhesion molecules, in immune responses, tumour progression and haematopoiesis.
Guenthert, U. and Schwaerzler, C. and Wittig, B. and Laman, J. and Ruiz, P. and Stauder, R. and Bloem, A. and Smadja-Joffe, F. and Zoeller, M. and Rolink, A.
Advances in Experimental Medicine and Biology 451
: 43-49.
1998
1997
From totipotent embryonic stem cells to spontaneously contracting smooth muscle cells: a retinoic acid and db-cAMP in vitro differentiation model.
Drab, M. and Haller, H. and Bychkov, R. and Erdmann, B. and Lindschau, C. and Haase, H. and Morano, I. and Luft, F.C. and Wobus, A.M.
FASEB Journal 11
(11): 905-915.
September 1997
Analysis of the E-cadherin and P-cadherin promoters in murine keratinocyte cell lines from different stages of mouse skin carcinogenesis.
Faraldo, M.L.M. and Rodrigo, I. and Behrens, J. and Birchmeier, W. and Cano, A.
Molecular Carcinogenesis 20
: 33-47.
1 January 1997
Expression of E-cadherin and catenins in invasive mammary carcinomas.
Zschiesche, W. and Schoenborn, I. and Behrens, J. and Herrenknecht, K. and Hartveit, F. and Lilleng, P. and Birchmeier, W.
Anticancer Research 17
: 561-567.
1 January 1997
Expression of E-cadherin/catenin complexes in breast cancer: correlation with favourable prognostic factors and survival.
Schoenborn, I. and Zschiesche, W. and Behrens, J. and Herrenknecht, K. and Birchmeier, W.
International Journal of Oncology 11
: 1327-1334.
1 January 1997
Hepatocyte growth factor/ scatter factor (HGF/SF) signals via the STAT3/APRF transcription factor in human hepatoma cells and hepatocytes.
Schaper, F. and Siewert, E. and Gomez-Lechon, M.J. and Gatsios, P. and Sachs, M. and Birchmeier, W. and Heinrich, P.C. and Castell, J.
FEBS Letters 405
: 99-103.
1 January 1997
Role of HGF/SF and c-Met in morphogenesis and metastasis of epithelial cells.
Birchmeier, W. and Brinkmann, V. and Niemann, C. and Meiners, S. and Dicesare, S. and Naundorf, H. and Sachs, M.
Ciba Foundation Symposia 212
: 230-240.
1 January 1997
1996
Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis.
Weidner, K.M. and Dicesare, S. and Sachs, M. and Brinkmann, V. and Behrens, J. and Birchmeier, W.
Nature 384
(6605): 173-176.
14 November 1996
Effects of intracellular angiotensin II in vascular smooth muscle cells.
Haller, H. and Lindschau, C. and Erdmann, B. and Quass, P. and Luft, F.C.
Circulation Research 79
(4): 765-772.
1 October 1996
Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart.
Ruiz, P. and Brinkmann, V. and Ledermann, B. and Behrend, M. and Grund, C. and Thalhammer, C. and Vogel, F. and Birchmeier, C. and Guenthert, U. and Franke, W.W. and Birchmeier, W.
Journal of Cell Biology 135
(1): 215-225.
October 1996
Mittel zur Beeinflussung der Zelldifferenzierung und seine Verwendung.
Birchmeier, W.
DE19509792A1.
19 September 1996
Functional interaction of beta-catenin with the transcription factor LEF-1.
Behrens, J. and von Kries, J.P. and Kuehl, M. and Bruhn, L. and Wedlich, D. and Grosschedl, R. and Birchmeier, W.
Nature 382
(6592): 638-642.
15 August 1996
Motogenic and morphogenic activity of epithelial receptor tyrosine kinases.
Sachs, M. and Weidner, K.M. and Brinkmann, V. and Walther, I. and Obermeier, A. and Ullrich, A. and Birchmeier, W.
Journal of Cell Biology 133
(5): 1095-1107.
3 June 1996
Attempts to Understand Metastasis Formation I - III. Part 1: Metastasis-Related Molecules.
Guenthert, U. and Birchmeier, W.
Springer, Berlin [u.a.].
1 January 1996
Attempts to Understand Metastasis Formation I - III. Part 2: Regulatory Factors.
Guenthert, U. and Birchmeier, W.
Springer, Berlin [u.a.].
1 January 1996
Attempts to Understand Metastasis Formation I - III. Part 3: Therapeutic Approaches to Metastasis Treatment.
Guenthert, U. and Schlag, P.M. and Birchmeier, W.
Springer, Berlin [u.a.].
1 January 1996
Epithelial differentiation and the control of metastasis in carcinomas.
Birchmeier, W. and Behrens, J. and Weidner, K.M. and Huelsken, J. and Birchmeier, C.
Current Topics in Microbiology and Immunology
: 117-135.
1 January 1996
Epithelial-mesenchymal transitions in cancer progression.
Birchmeier, C. and Birchmeier, W. and Brand-Saberi, B.
Acta Anatomica 156
: 217-226.
1 January 1996
Expression of cytochrome P45011B1 mRNA in the brain of normal and hypertensive transgenic rats.
Erdmann, B. and Gerst, H. and Lippoldt, A. and Buelow, H. and Ganten, D. and Fuxe, K. and Bernhardt, R.
Brain Research 733
: 73-82.
1 January 1996
Mechanisms identified in the transcriptional control of epithelial gene expression.
Hennig, G. and Loewrick, O. and Birchmeier, W. and Behrens, J.
Journal of Biological Chemistry 271
: 595-602.
1 January 1996
Prognostic value of E-cadherin expression in 413 gastric carcinomas.
Gabbert, H.E. and Mueller, W. and Schneiders, A. and Meier, S. and Moll, R. and Birchmeier, W. and Hommel, G.
International Journal of Cancer 69
: 184-189.
1 January 1996
Subcellular localization of angiotensin II immunoreactivity in the rat cerebellar cortex.
Erdmann, B. and Fuxe, K. and Ganten, D.
Hypertension 28
: 818-824.
1 January 1996
1995
Hepatocyte growth factor/scatter factor induces a variety of tissue-specific morphogenic programs in epithelial cells.
Brinkmann, V. and Foroutan, H. and Sachs, M. and Weidner, K.M. and Birchmeier, W.
Journal of Cell Biology 131
(6 Pt. 1): 1573-1586.
December 1995
V-src kinase shifts the cadherin-based cell adhesion from the strong to the weak state and beta-catenin is not required for the shift.
Takeda, H. and Nagafuchi, A. and Yonemura, S. and Tsukita, S. and Behrens, J. and Birchmeier, W. and Tsukita, S.
Journal of Cell Biology 131
(6 Pt. 2): 1839-1847.
December 1995
Sequential requirement of hepatocyte growth factor and neuregulin in the morphogenesis and differentiation of the mammary gland.
Yang, Y. and Spitzer, E. and Meyer, D. and Sachs, M. and Niemann, C. and Hartmann, G. and Weidner, K.M. and Birchmeier, C. and Birchmeier, W.
Journal of Cell Biology 131
(1): 215-226.
October 1995
Adherens junction proteins in tumour progression.
Birchmeier, W. and Huelsken, J. and Behrens, J.
Cancer Surveys 24
: 129-140.
1 January 1995
Characterization of the scatter factor/hepatocyte growth factor gene promoter - positive and negative regulatory elements direct gene expression to mesenchymal cells.
Plaschke-Schluetter, A. and Behrens, J. and Gherardi, E. and Birchmeier, W.
Journal of Biological Chemistry 270
: 830-836.
1 January 1995
Clinical significance of e-cadherin as a prognostic marker in thyroid carcinomas.
Scheumman, G.F.W. and Hoangvu, C. and Cetin, Y. and Gimm, O. and Behrens, J. and von Wasielewski, R. and Georgii, A. and Birchmeier, W. and von zur Muehlen, A. and Dralle, H. and Brabant, G.
Journal of Clinical Endocrinology and Metabolism 80
(7): 2168-2172.
1 January 1995
E-cadherin as a tumor (invasion) suppressor gene.
Birchmeier, W.
BioEssays 17
: 97-99.
1 January 1995
E-cadherin as an invasion suppressor.
Birchmeier, W. and Huelsken, J. and Behrens, J.
Ciba Foundation Symposia 189
: 124-136, discussion 136-41, 174-6.
1 January 1995
EGF and TGFalpha modulate structural and functional differentiation of the mammary gland from pregnant mice in vitro: Possible role of the arachidomic pathway.
Spitzer, E. and Zschiesche, W. and Binas, B. and Grosse, R. and Erdmann, B.
Journal of Cellular Biochemistry 57
: 495-508.
1 January 1995
Epithelial-mesenchymal transitions in development and tumor progression.
Birchmeier, W. and Birchmeier, C.
In:
Epithelial-Mesenchymal Interactions in Cancer.
Birkhaeuser, Basel, 1-15.
1 January 1995
Human adrenal CYP11B1: localization by in situ-hybridization and functional expression in cell cultures.
Erdmann, B. and Denner, K. and Gerst, H. and Lenz, D. and Bernhardt, R.
Endocrine Research 21
: 425-435.
1 January 1995
Mutation of juxtamembrane tyrosine residue 1001 suppresses loss-of-function mutations of the met receptor in epithelial cells.
Weidner, K.M. and Sachs, M. and Riethmacher, D. and Birchmeier, W.
Proceedings of the National Academy of Sciences of the United States of America 92
: 2597-2601.
1 January 1995
Progression of carcinoma cells is associated with alterations in chromatin structure and factor binding at the E-cadherin promoter in vivo.
Hennig, G. and Behrens, J. and Truss, M. and Frisch, S. and Reichmann, E. and Birchmeier, W.
Oncogene 11
: 475-484.
1 January 1995
Surgical and multimodal approaches to liver metastases.
Schlag, P.M. and Huenerbein, M. and Hohenberger, P.
In:
Attempts to Understand Metastasis Formation.
Springer, Berlin [u.a.], 241-256.
1 January 1995
Zone-specific localization of cytochrome P45011B1 in human adrenal tissue by PCR-derived riboprobes.
Erdmann, B. and Gerst, H. and Buelow, H. and Lenz, D. and Baehr, V. and Bernhardt, R.
Histochemistry and Cell Biology 104
: 301-307.
1 January 1995
1994
E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton.
Huelsken, J. and Birchmeier, W. and Behrens, J.
Journal of Cell Biology 127
(6 Pt. 2): 2061-2069.
December 1994
Inverse relation of E-cadherin and autocrine motility factor receptor expression as a prognostic factor in patients with bladder carcinomas.
Otto, T. and Birchmeier, W. and Schmidt, U. and Hinke, A. and Schipper, J. and Ruebben, H. and Raz, A.
Cancer Research 54
(12): 3120-3123.
15 June 1994
Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness.
Birchmeier, W. and Behrens, J.
Biochimica et Biophysica Acta 1198
(1): 11-26.
27 May 1994
E-cadherin gene mutations in human gastric carcinoma cell lines.
Oda, T. and Kanai, Y. and Oyama, T. and Yoshiura, K. and Shimoyama, Y. and Birchmeier, W. and Sugimura, T. and Hirohashi, S.
Proceedings of the National Academy of Sciences of the United States of America 91
(5): 1858-1862.
1 March 1994
Cell-cell adhesion in invasion and metastasis of carcinomas.
Behrens, J. and Birchmeier, W.
In:
Mammary Tumorigenesis and Malignant Progression.
Kluwer Acad. Publ., Norwell, MA, 251-266.
1 January 1994
Differences of E-cadherin expression levels and patterns in primary and metastatic human lung cancer.
Boehm, M. and Totzeck, B. and Birchmeier, W. and Wieland, I.
Clinical and Experimental Metastasis 12
: 55-62.
1 January 1994
Immunocytochemical localization of heterologously expressed adrenodoxin and its electron acceptor cytochrome P45011B1 in Escherichia coli.
Erdmann, B. and Henning, M. and Uhlmann, H. and Beckert, V. and Grunau, C. and Bernhardt, R.
European Journal of Cell Biology 65
: 220-228.
1 January 1994
Localization of mammary-derived growth inhibitor in capillary endothelial cells of the bovine mammary gland.
Breter, H. and Erdmann, B.
Cell and Tissue Research 277
: 457-464.
1 January 1994
Localization of the human beta-catenin gene (CTNNB1) to 3p21: A region implicated in tumor development.
Kraus, C. and Liehr, T. and Huelsken, J. and Behrens, J. and Birchmeier, W. and Grzeschik, K.H. and Ballhausen, W.G.
Genomics 23
: 272-274.
1 January 1994
Mesenchymal-epithelial transitions.
Birchmeier, W. and Birchmeier, C.
BioEssays 16
: 305-307.
1 January 1994
Molecular aspects of the loss of cell adhesion and gain of invasiveness in carcinomas.
Birchmeier, W.
In:
Proceedings of the international symposium of the Princess Takamatsu Cancer Research Fund.
Princess Takamatsu Symposia ; 24
.
University of Tokyo Press, Tokyo, 214-232.
1 January 1994
The motility signal of scatter factor /hepatocyte growth factor mediated through the receptor tyrosine kinase Met requires intracellular action of Ras.
Hartmann, G. and Weidner, K.M. and Schwarz, H. and Birchmeier, W.
Journal of Biological Chemistry 269
: 21936-21939.
1 January 1994
Tumor-suppressor gene products in cell contacts: the cadherin-APC-armadillo connection.
Huelsken, J. and Behrens, J. and Birchmeier, W.
Current Opinion in Cell Biology 6
: 711-716.
1 January 1994
1993
Differential loss of E-Cadherin expression in infiltrating ductal and lobular breast carcinomas.
Moll, R. and Mitze, M. and Frixen, U.H. and Birchmeier, W.
American Journal of Pathology 143
(6): 1731-1742.
1 December 1993
Deletion of the e-Cadherin gene in hepatitis-B virus-positive chinese hepatocellular carcinomas.
Slagle, B.L. and Zhou, Y.Z. and Birchmeier, W. and Scorsone, K.A.
Hepatology 18
(4): 757-762.
1 October 1993
Molecular mechanisms leading to cell junction (cadherin) deficiency in invasive carcinomas.
Birchmeier, W. and Weidner, K.M. and Huelsken, J. and Behrens, J.
Seminars in Cancer Biology 4
(4): 231-239.
1 August 1993
E-cadherin expression in primary and metastatic gastric cancer: down-regulation correlates with cellular dedifferentiation and glandular disintegration.
Mayer, B. and Johnson, J.P. and Leitl, F. and Jauch, K.W. and Heiss, M.M. and Schildberg, F.W. and Birchmeier, W. and Funke, I.
Cancer Research 53
(7): 1690-1695.
1 April 1993
The Met receptor tyrosine kinase transduces motility, proliferation, andmorphogenic signals of scatter factor/ hepatocyte growth factor in epithelial cells.
Weidner, K.M. and Sachs, M. and Birchmeier, W.
Journal of Cell Biology 121
(1): 145-154.
April 1993
Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/?catenin complex in cells transformed with a temperature-sensitive v-SRC gene.
Behrens, J. and Vakaet, L. and Friis, R. and Winterhager, E. and van Roy, F. and Mareel, M.M. and Birchmeier, W.
Journal of Cell Biology 120
(3): 757-766.
February 1993
Irregular distribution of mammary-derived growth inhibitor in the bovine mammary epithelium.
Erdmann, B. and Breter, H.
Cell and Tissue Research 272
: 383-389.
1 January 1993
Molecular characteristics of HGF-SF and its role in cell motility and invasion.
Weidner, K.M. and Hartmann, G. and Naldini, L. and Comoglio, P.M. and Sachs, M. and Fonatsch, C. and Rieder, H. and Birchmeier, W.
In:
Hepatocyte Growth Factor (HGF-SF) and the C-Met Receptor.
Birkhaeuser, Basel, 311-328.
1 January 1993
Molecular mechanisms leading to loss of differentiation and gain of invasiveness in epithelial cells.
Birchmeier, W. and Weidner, K.M. and Behrens, J.
Journal of Cell Science Suppl. 17
: 159-164.
1 January 1993
Properties and functions of scatter factor/hepatocyte growth factor and its receptor c-Met.
Weidner, K.M. and Hartmann, G. and Sachs, M. and Birchmeier, W.
American Journal of Respiratory Cell and Molecular Biology 8
: 229-237.
1 January 1993
Suitability of different protein a-gold markers for immunogold- silver staining in paraffin sections.
Breter, H. and Erdmann, B.
Biotechnic and Histochemistry 68
: 206-210.
1 January 1993
Undercoat-constitutive proteins of cell-cell adherens junctions.
Birchmeier, W.
Japanese Journal of Cancer Research 84
: 1332-1333.
1 January 1993
Molecular aspects of mesenchymal-epithelial interactions.
Birchmeier, C. and Birchmeier, W.
Annual Review of Cell Biology 9
: 511-540.
1993
1992
Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor.
Naldini, L. and Tamagnone, L. and Vigna, E. and Sachs, M. and Hartmann, G. and Birchmeier, W. and Daikuhara, Y. and Tsubouchi, H. and Blasi, F. and Comoglio, P.M.
EMBO Journal 11
(13): 4825-4833.
1 December 1992
Verfahren zum Nachweis der Differenzierung und der Invasivitaet von Karzinomzellen.
Birchmeier, W. and Frixen, U. and Behrens, J.
DE4110405A1 ; EP0582582A1 ; EP0582582B1.
1 October 1992
Hormonal induction of functional differentiation and mammary-derived growth inhibitor expression in cultured mouse mammary gland explants.
Binas, B. and Spitzer, E. and Zschiesche, W. and Erdmann, B. and Kurtz, A. and Mueller, T. and Niemann, C. and Blenau, W. and Grosse, R.
In Vitro Cellular & Developmental Biology 28A
(9-10): 625-634.
September 1992
A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesis.
Hartmann, G. and Naldini, L. and Weidner, K.M. and Sachs, M. and Vigna, E. and Comoglio, P.M. and Birchmeier, W.
Proceedings of the National Academy of Sciences of the United States of America 89
: 11574-11578.
1 January 1992
Cell adhesion in invasion and metastasis.
Behrens, J. and Frixen, U. and Schipper, J. and Weidner, K.M. and Birchmeier, W.
Seminars in Cell Biology 3
: 169-178.
1 January 1992
Molecular aspects of the invasion of carcinoma cells.
Birchmeier, W. and Weidner, K.M. and Behrens, J.
In:
Metastasis : Basic Research and its Clinical Application.
Karger, Basel, 95-107.
1 January 1992
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