Helmholtz Gemeinschaft


Molecular mechanisms leading to cell junction (cadherin) deficiency in invasive carcinomas

Item Type:Article
Title:Molecular mechanisms leading to cell junction (cadherin) deficiency in invasive carcinomas
Creators Name:Birchmeier, W., Weidner, K.M., Huelsken, J. and Behrens, J.
Abstract:It has been realized for some time that the loss of epithelial differentiation in carcinomas, which is accompanied by higher mobility and invasiveness of the tumor cells, is a consequence of reduced intercellular adhesion. A variety of recent reports have indicated that the primary cause for the 'scattering' of the cells in invasive carcinomas is a loss of the integrity of intercellular adherens junctions often involving loss of a functional cell-cell adhesion molecule E-cadherin. In the present review, permanent and transient molecular mechanisms are discussed which lead to the impairment of junctional integrity of cells and thus the progression of carcinomas toward a more metastatic state.
Keywords:Base Sequence, Cadherins, Cell Adhesion, Cell Movement, Neoplasm DNA, Neoplastic Gene Expression Regulation, Hepatocyte Growth Factor, Intercellular Junctions, Molecular Sequence Data, Neoplasm Metastasis, Neoplasms, Genetic Promoter Regions, Cultured Tumor Cells, Animals, Chickens, Mice, Rats
Source:Seminars in Cancer Biology
Publisher:Elsevier / Academic Press
Page Range:231-239
Date:1 August 1993
PubMed:View item in PubMed

Repository Staff Only: item control page

Open Access
MDC Library