Preprint

Kidney disease reprograms microbiome-host signaling to promote heart failure.
Yarritu, Alex ORCID: https://orcid.org/0000-0002-1724-0559, Anders, Wibke ORCID: https://orcid.org/0009-0000-6069-4233, Thiele, Arne ORCID: https://orcid.org/0000-0003-0786-2239, Potapenko, Olena ORCID: https://orcid.org/0000-0002-4397-568X, Schumacher, Fabian ORCID: https://orcid.org/0000-0001-8703-3275, Szijártó, István A. ORCID: https://orcid.org/0000-0002-0796-9450, Matz-Rauch, Ariana ORCID: https://orcid.org/0000-0002-5152-5830, Versnjak, Jakob ORCID: https://orcid.org/0009-0009-6179-1014, Gebremedhin, Natnael ORCID: https://orcid.org/0009-0001-2250-9436, McParland, Victoria ORCID: https://orcid.org/0000-0003-0731-3272, Heckscher, Simon, Kamboj, Sakshi ORCID: https://orcid.org/0000-0001-9618-012X, Trimarchi, Giuseppe ORCID: https://orcid.org/0009-0009-5558-3112, Anandakumar, Harithaa ORCID: https://orcid.org/0009-0000-3326-5126, Fuckert, Franziska ORCID: https://orcid.org/0009-0000-1371-2929, Hoffmann, Carina ORCID: https://orcid.org/0009-0004-3653-3607, Hassan, Sara A. ORCID: https://orcid.org/0009-0003-1210-5045, Bonnekoh, Paul M. ORCID: https://orcid.org/0009-0009-3483-1041, Wimmer, Moritz I. ORCID: https://orcid.org/0009-0004-5793-0249, Behrens, Felix ORCID: https://orcid.org/0000-0002-6841-4192, Voelkl, Jakob ORCID: https://orcid.org/0000-0002-6318-5087, Kramann, Rafael ORCID: https://orcid.org/0000-0003-4048-6351, Kintscher, Ulrich ORCID: https://orcid.org/0000-0001-7386-0990, Kuehne, Titus ORCID: https://orcid.org/0009-0002-1849-4013, Kleuser, Burkhard ORCID: https://orcid.org/0000-0002-1888-9595, Zernecke, Alma ORCID: https://orcid.org/0000-0001-8551-4729, Oefner, Peter J. ORCID: https://orcid.org/0000-0002-1499-3977, Gronwald, Wolfram ORCID: https://orcid.org/0000-0003-3646-0060, Dettmer, Katja ORCID: https://orcid.org/0000-0001-7337-2380, Eckardt, Kai-Uwe ORCID: https://orcid.org/0000-0003-3823-0920, Müller, Dominik N. ORCID: https://orcid.org/0000-0003-3650-5644, Kelm, Marcus ORCID: https://orcid.org/0000-0003-4971-0452, Holle, Johannes ORCID: https://orcid.org/0000-0001-8032-4096, Bartolomaeus, Hendrik ORCID: https://orcid.org/0000-0003-4288-3828 and Wilck, Nicola ORCID: https://orcid.org/0000-0003-3189-5364
bioRxiv : 2026.01.10.698142. 8 June 2026

Endothelin-1 signaling regulates chamber-specific mouse atrial cardiomyocyte cytokinesis and polyploidy.
Lan, Tian, Kaminsky, Sabrina, Rinck, Lorna, Andrasch, Yannik ORCID: https://orcid.org/0009-0004-6019-2574, Zickgraf, Eva, Singhal, Mahak ORCID: https://orcid.org/0000-0002-7303-9585 and Wu, Chi-Chung ORCID: https://orcid.org/0000-0003-3903-2512
bioRxiv : 2026.05.26.727795. 28 May 2026

Pre-existing chromatin accessibility primes δ-cells for injury-induced endocrine plasticity.
Gräßlin, Jo ORCID: https://orcid.org/0000-0003-0641-9913, Chawla, Prateek, Subramanian, Padmapriya, Rajendran, Anuradha, Walda, Emilie Ida Christine, Froschauer, Alexander, Ninov, Nikolay and Junker, Jan Philipp ORCID: https://orcid.org/0000-0002-2826-8290
bioRxiv : 2026.05.24.727280. 27 May 2026

mehari: high-performance, strict HGVS-first variant effect prediction.
Hartmann, Till ORCID: https://orcid.org/0000-0002-6993-347X, Zhao, Max ORCID: https://orcid.org/0000-0001-7259-1901, Beule, Dieter ORCID: https://orcid.org/0000-0002-3284-0632 and Holtgrewe, Manuel ORCID: https://orcid.org/0000-0002-3051-1763
bioRxiv : 2026.05.12.724271. 14 May 2026

Global quantification of mammalian gene expression noise.
Welter, Anna Sophie ORCID: https://orcid.org/0009-0003-9846-3889, Mutschler, Florian ORCID: https://orcid.org/0009-0002-0992-7171, Simon, Mareike ORCID: https://orcid.org/0000-0001-7213-9499, Giacomelli, Chiara ORCID: https://orcid.org/0000-0003-1466-1371, Branscheid, Ann-Christin, Manukyan, Artur ORCID: https://orcid.org/0000-0002-0441-9517, Teixeira Alves, Luiz Gustavo ORCID: https://orcid.org/0000-0002-5822-4168, Gerwien, Maximilian ORCID: https://orcid.org/0000-0002-2884-4155, Kerridge, Robert, Landthaler, Markus ORCID: https://orcid.org/0000-0002-1075-8734, Wolf, Jana ORCID: https://orcid.org/0000-0003-3254-5868 and Selbach, Matthias ORCID: https://orcid.org/0000-0003-2454-8751
bioRxiv : 2026.05.11.724258. 14 May 2026

Endothelial YAP/TAZ rewiring under cardiometabolic stress drives sex-divergent vascular remodeling in heart failure with preserved ejection fraction.
Klaus-Bergmann, Alexandra ORCID: https://orcid.org/0000-0002-1164-3322, Sievers, Laura Katharina, Versnjak, Jakob, Koch, Katharina, Nawara, Tomasz ORCID: https://orcid.org/0000-0002-4801-4095, Bartels-Klein, Eireen, Popp, Oliver ORCID: https://orcid.org/0000-0001-6240-4666, Weiner 3rd, January ORCID: https://orcid.org/0000-0003-1438-7819, Meier, Katja, Hollfinger, Irene ORCID: https://orcid.org/0000-0002-6233-8395, Kamer, Ilona, Taube, Martin, Heuser, Arnd ORCID: https://orcid.org/0000-0002-3334-960X, Borodina, Tatiana ORCID: https://orcid.org/0000-0002-6978-016X, Beule, Dieter ORCID: https://orcid.org/0000-0002-3284-0632, Potente, Michael ORCID: https://orcid.org/0000-0002-5689-0036, Landmesser, Ulf ORCID: https://orcid.org/0000-0002-0214-3203, Mertins, Philipp ORCID: https://orcid.org/0000-0002-2245-528X, Kelm, Marcus, Muller, Dominik N. ORCID: https://orcid.org/0000-0003-3650-5644 and Gerhardt, Holger ORCID: https://orcid.org/0000-0002-3030-0384
bioRxiv : 2026.05.07.723127. 13 May 2026

Epithelial mesenchymal transition initiates precancer states in BRCA1 mutation carriers.
Bar-Hai, Neta, Ben-Yishay, Rakefet, Arbili-Yarhi, Sheli, Bernstein-Molho, Rinat, Goldinger, Gil, Balint-Lahat, Nora, Menes, Tehillah, Herman, Naama, Noy, Vered, Mansour, Aiham, Globus, Opher, Hilman, Pnina, Zehavi, Yonathan, Eizenberg-Magar, Inbal, Mahammadov, Elmir ORCID: https://orcid.org/0000-0003-0008-1413, Conrad, Thomas ORCID: https://orcid.org/0000-0001-5618-6295, Rajewsky, Nikolaus ORCID: https://orcid.org/0000-0002-4785-4332, Antebi, Yaron E., Berger, Raanan and Ishay-Ronen, Dana
bioRxiv : 2026.05.06.723061. 11 May 2026

InterScale reveals multi-scale cellular interaction programs in spatial transcriptomics.
Drummer, Francesca K. ORCID: https://orcid.org/0009-0002-7156-9125, Jimenez, Sara ORCID: https://orcid.org/0000-0001-7103-7474, Marco, Federico Di ORCID: https://orcid.org/0000-0003-0376-1342, Schaar, Anna C. ORCID: https://orcid.org/0000-0003-1063-005X, Pentimalli, Tancredi Massimo ORCID: https://orcid.org/0000-0002-8461-7918, Beckmann, Julia, Rajewsky, Nikolaus ORCID: https://orcid.org/0000-0002-4785-4332 and Theis, Fabian J. ORCID: https://orcid.org/0000-0002-2419-1943
bioRxiv : 2026.05.07.723456. 11 May 2026

pyTrance finds co-localizing RNAs in subcellular spatial transcriptomics data.
Strenger, Leon ORCID: https://orcid.org/0009-0005-0354-8631, Cerda-Jara, Cledi Alicia ORCID: https://orcid.org/0000-0003-1783-5533, Karaiskos, Nikos ORCID: https://orcid.org/0000-0001-7771-3947 and Rajewsky, Nikolaus ORCID: https://orcid.org/0000-0002-4785-4332
bioRxiv : 2026.05.07.723470. 11 May 2026

Novel mouse reporter models for the detection of genome editing events in vivo.
Snow, Kathy J. ORCID: https://orcid.org/0009-0006-5565-0619, Saville, Ethan ORCID: https://orcid.org/0009-0001-6564-5753, Heffner, Caleb ORCID: https://orcid.org/0000-0002-2631-6201, Gaitan, Yaned ORCID: https://orcid.org/0009-0002-4356-1812, Duryea, Jeffrey ORCID: https://orcid.org/0000-0001-7692-9340, Davis, Tiffany L. ORCID: https://orcid.org/0009-0001-3643-9977, Bechtel, Lawrence, Hannigan, Seth ORCID: https://orcid.org/0009-0004-7521-7439, Low, Benjamin E. ORCID: https://orcid.org/0000-0003-0350-4602, Rossius, Jana ORCID: https://orcid.org/0009-0000-6011-9714, Dang, Tu ORCID: https://orcid.org/0009-0001-0138-7599, Kulhankova, Katarina ORCID: https://orcid.org/0000-0001-7189-2323, Cheng, Anna X. ORCID: https://orcid.org/0000-0003-1727-9485, Wiles, Michael V. ORCID: https://orcid.org/0000-0002-3620-8386, Wurst, Wolfgang ORCID: https://orcid.org/0000-0003-4422-7410, McCray, Paul B. ORCID: https://orcid.org/0000-0002-4067-577X, Guay, David ORCID: https://orcid.org/0000-0003-0508-1703, Lutz, Cathleen M. ORCID: https://orcid.org/0000-0003-2502-1900, Bergstrom, David E. ORCID: https://orcid.org/0000-0003-0352-5411, Kuehn, Ralf ORCID: https://orcid.org/0000-0003-1694-9803 and Murray, Stephen A. ORCID: https://orcid.org/0000-0002-0594-1702
bioRxiv : 2026.04.29.721708. 2 May 2026

Spatial single-cell proteomics reveals molecular trajectories of tangle-bearing neurons in Alzheimer’s disease.
Foiani, M.S. ORCID: https://orcid.org/0000-0003-4157-2606, Bourdenx, M. ORCID: https://orcid.org/0000-0002-9799-9222, Kraller, L. ORCID: https://orcid.org/0009-0006-9785-3596, Nirujogi, R.S. ORCID: https://orcid.org/0000-0002-3177-8566, Yiu, A., Davies, H., Patel, S., Damoc, L.S., Mitchener, L., Jaunmuktane, Z. ORCID: https://orcid.org/0000-0001-7738-8881, Coscia, F. ORCID: https://orcid.org/0000-0002-2244-5081 and Duff, K.E. ORCID: https://orcid.org/0000-0002-6177-868X
bioRxiv : 2026.04.26.720932. 29 April 2026

A generative AI framework for disease-specific lung microtissue bioengineering.
Bahry, Ella ORCID: https://orcid.org/0000-0002-6358-2576, Pestoni, Jeanine C., Hirzel, Kai, Savchyn, Taras, Porras-Gonzalez, Diana, Getmanchuk-Zaporoshchenko, Vera, Gregor, Martin, Conlon, Thomas M, Önder Yildirim, Ali, Harrington, Kyle ORCID: https://orcid.org/0000-0002-7237-1973, Schmidt, Deborah ORCID: https://orcid.org/0000-0002-8621-9438, Burgstaller, Gerald and Heymann, Michael
bioRxiv : 2026.04.15.718723. 16 April 2026

A bio-orthogonal and covalent 5 kDa small protein tag.
Pabst, Ulrich ORCID: https://orcid.org/0009-0007-0529-0720, Rossius, Jana ORCID: https://orcid.org/0009-0000-6011-9714, Olesen, Christina Holmboe ORCID: https://orcid.org/0000-0002-0575-1597, Birol, Melissa ORCID: https://orcid.org/0000-0003-3397-8446 and Broichhagen, Johannes ORCID: https://orcid.org/0000-0003-3084-6595
bioRxiv : 2026.04.10.717487. 10 April 2026

MicroRNAs are required within a critical time window to define neural patterning during early human brain development.
Emmenegger, Lisa ORCID: https://orcid.org/0000-0003-2165-7944, Cerda Jara, Cledi Alicia ORCID: https://orcid.org/0000-0003-1783-5533, Ercolano, Matilde ORCID: https://orcid.org/0009-0009-5966-2141, Loebert, Jaden, Morando, Nicolas, Bhaskar, Poojashree ORCID: https://orcid.org/0009-0006-0027-7239, Legnini, Ivano ORCID: https://orcid.org/0000-0002-8984-5215, Rybak-Wolf, Agnieszka ORCID: https://orcid.org/0000-0002-1192-5290 and Rajewsky, Nikolaus ORCID: https://orcid.org/0000-0002-4785-4332
bioRxiv : 2026.03.30.715268. 1 April 2026

HAP40 functions as a proteostasis regulator by controlling huntingtin interactions and its release into the extracellular space.
Silva Ramos, Eduardo ORCID: https://orcid.org/0000-0002-8520-9107, Boeddrich, Annett ORCID: https://orcid.org/0000-0001-9118-050X, Haenig, Christian ORCID: https://orcid.org/0000-0003-1973-7646, Trepte, Philipp ORCID: https://orcid.org/0000-0002-8141-6272, Ammar, Orchid ORCID: https://orcid.org/0009-0003-5341-4434, Secker, Christopher ORCID: https://orcid.org/0000-0002-7222-536X, Popp, Oliver ORCID: https://orcid.org/0000-0001-6240-4666, Ivanov, Andranik ORCID: https://orcid.org/0000-0002-4824-1925, Keith, Brandon, Harding, Rachel J. ORCID: https://orcid.org/0000-0002-1134-391X, Schindler, Franziska ORCID: https://orcid.org/0000-0002-3320-8284, Koudelka, Tomas ORCID: https://orcid.org/0009-0008-2895-6051, Roth, Leonard, Scharek, Nadine, Zenkner, Martina, Neuendorf, Nancy, Golusik, Sabrina, Beetz, Stephanie, Mertins, Philipp ORCID: https://orcid.org/0000-0002-2245-528X, Piazza, Ilaria ORCID: https://orcid.org/0000-0001-5895-6134, Schnoegl, Sigrid and Wanker, Erich E. ORCID: https://orcid.org/0000-0001-8072-1630
bioRxiv : 2026.03.31.715351. 1 April 2026

Mitochondrial heteroplasmy disrupts osteoclast differentiation and bone resorption by impairing respiratory complex I.
Leng, Houfu ORCID: https://orcid.org/0000-0002-4023-8588, Jiang, Jiahao ORCID: https://orcid.org/0009-0009-5712-5289, Gassner, Katja, Midha, Swati, Justo-Méndez, Raquel, Zheng, Jianqing, Hall, Timothy, Luo, Lin ORCID: https://orcid.org/0000-0003-2300-5448, West, Suzanne D., Vincent, Tonia L., Wann, Angus, Patel, Kashyap A., Poulton, Joanna, O'Callaghan, Chris A., Lechuga-Vieco, Ana Victoria ORCID: https://orcid.org/0000-0001-5546-9752 and Simon, Anna Katharina ORCID: https://orcid.org/0000-0002-4077-7995
bioRxiv : 2025.05.02.651799v4. 25 March 2026

Interferon-independent STING enforces epithelial genome-integrity checkpoint to restrain tumor evolution.
Xiang, Hang, Macino, Martina ORCID: https://orcid.org/0000-0002-8730-9005, Woitaske-Proske, Clemens, Bodenstein, Nicholas, Bernardes, Joana P., Tran, Florian, Schmid, Nicole A., Martini, Gabriela Rios, Wotawa, Felix, Bornhaeuser, Johanna, Kakavand, Nassim, Dyck Dionisi, Oliver ORCID: https://orcid.org/0000-0002-0410-1736, van den Bossche, Silke, Yang, Guang, Wu, Qicong, Kugler, Julia, Welz, Lina, Konukiewitz, Bjorn, Fischer, Julius C., Peifer, Christian, Schreiber, Stefan, Rosenstiel, Philip, Tschurtschenthaler, Markus ORCID: https://orcid.org/0000-0002-0060-4790, Sanders, Ashley D. ORCID: https://orcid.org/0000-0003-3945-0677 and Aden, Konrad ORCID: https://orcid.org/0000-0003-3482-7316
bioRxiv : 2026.02.17.706442v2. 25 March 2026

Cardiomyocyte autophagy promotes a pro-regenerative immune response during cardiac regeneration.
Constanty, Florian, Wu, Bailin ORCID: https://orcid.org/0000-0001-5234-6773, Shekhar, Srishti, Bektimirova, Alina, Bakali, Vasiliki, Blasco Almodovar, Lucia, Senger, Frauke, Frey, Norbert and Beisaw, Arica ORCID: https://orcid.org/0000-0002-6658-6978
bioRxiv : 2026.03.16.712191. 18 March 2026

FYCO1 improves postischemic cardiac remodeling via enhanced autophagic flux and attenuation of proinflammatory signaling.
Senger, Frauke, Hille, Susanne S., Remes, Anca Kliesow, Baral, Tapan K., Martin-Garrido, Abel, Schmiedel, Nesrin, Kuhn, Christian, Müller, Oliver J., Rangrez, Ashraf Y., Backs, Johannes ORCID: https://orcid.org/0000-0002-2322-2699, Beisaw, Arica ORCID: https://orcid.org/0000-0002-6658-6978, Heineke, Jörg and Frey, Norbert
bioRxiv : 2026.03.17.712297. 18 March 2026

Context-dependent reshaping of defensive responses to predators in head-fixed and freely moving mice.
Ritter, Marti ORCID: https://orcid.org/0009-0004-7819-4818, Barreira, Lara Mariel Chirich, Sach, Lara ORCID: https://orcid.org/0009-0008-0376-7959, Hakus, Aileen ORCID: https://orcid.org/0000-0002-5355-8660, Öktem, Sanra Kumsal, Bergmann, Ronny, Voigt, Anne, Schmitz, Dietmar ORCID: https://orcid.org/0000-0003-2741-5241, Poirazi, Panayiota ORCID: https://orcid.org/0000-0001-6152-595X, Larkum, Matthew E. ORCID: https://orcid.org/0000-0001-9799-2656 and Sachdev, Robert N.S. ORCID: https://orcid.org/0000-0002-6627-0199
bioRxiv : 2025.06.09.658679v3. 16 March 2026

Mind the translational gap: human microglia differ from mouse microglia in their regulation of Kv and Kir2.1 channels.
Schilling, Simone ORCID: https://orcid.org/0000-0001-9850-5530, Felk, Jessica, Kikhia, Majed, Podesta, Alice, Hintze, Johanna, Fidzinski, Pawel, Holtkamp, Martin, Onken, Julia, Sauvigny, Thomas, Kalbhenn, Thilo, Simon, Matthias, Kettenmann, Helmut ORCID: https://orcid.org/0000-0001-8208-0291, Endres, Matthias, Goettert, Ria ORCID: https://orcid.org/0000-0003-4756-7381 and Gertz, Karen ORCID: https://orcid.org/0000-0002-1203-641X
bioRxiv : 2026.03.10.710589. 10 March 2026

Oncogene inactivation-induced senescence facilitates tumor relapse.
Schmitt, P., Hönig, K., Norcia, M.T., Nogueira, M.F. ORCID: https://orcid.org/0000-0002-7607-4570, Flore, V. ORCID: https://orcid.org/0009-0001-3023-433X, Vesperinas, I.S., Villoro-Agud, M., Peng, L., Safyürek, Z. ORCID: https://orcid.org/0009-0004-8412-5069, Tariq, M. ORCID: https://orcid.org/0009-0003-5217-2226, Milojkovic, A., Anders, K. ORCID: https://orcid.org/0000-0002-0429-200X, Schröck, E., Sauer, S. ORCID: https://orcid.org/0000-0002-4794-3693, Uyar, B. ORCID: https://orcid.org/0000-0002-3170-4890, Akalin, A. ORCID: https://orcid.org/0000-0002-0468-0117, Willimsky, G. ORCID: https://orcid.org/0000-0002-9693-948X, Haas, S. ORCID: https://orcid.org/0000-0001-9227-2051, Martínez-Reyes, I. ORCID: https://orcid.org/0000-0003-0479-1535 and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
bioRxiv : 2024.07.13.603369. 5 March 2026

Atomic structure and plasticity of the CTX-MthK complex investigated by cryo-EM, NMR, and MD simulations.
Qoraj, Denis, Mohr, Swantje, Aldakul, Yessenbek K., Sprink, Thiemo ORCID: https://orcid.org/0000-0002-0760-6828, Öster, Carl, Xiao, Taoran, Schmieder, Peter ORCID: https://orcid.org/0000-0001-9968-9327, Lange, Sascha, Utesch, Tillmann, Roderer, Daniel ORCID: https://orcid.org/0000-0002-7276-3467, Chen, Shanshuang, Sun, Han and Lange, Adam
bioRxiv : 2026.02.20.706983v2. 3 March 2026

Quantification of the effects of single nucleotide variants in NKX2.1 transcription factor binding sites.
Lenihan-Geels, Freyda ORCID: https://orcid.org/0000-0002-4984-674X, Proft, Sebastian, Bommer, Martin ORCID: https://orcid.org/0000-0003-3195-9129, Heinemann, Udo ORCID: https://orcid.org/0000-0002-8191-3850, Seelow, Dominik ORCID: https://orcid.org/0000-0002-9746-4412, Opitz, Robert ORCID: https://orcid.org/0000-0003-3143-0997, Krude, Heiko ORCID: https://orcid.org/0000-0002-1169-0348, Schuelke, Markus ORCID: https://orcid.org/0000-0003-2824-3891 and Małecka, Maria ORCID: https://orcid.org/0000-0001-8339-3230
bioRxiv : 2026.02.27.708450v2. 2 March 2026

Bradykinin contributes to vasogenic edema in murine experimental cerebral malaria.
Pinheiro, Alessandro de Sa ORCID: https://orcid.org/0009-0003-2384-8733, Teixeira, Douglas E., Silva-Aguiar, Rodrigo P. ORCID: https://orcid.org/0000-0003-1975-8033, Shim, Young Jun, Merkulova, Alona, Silbak, Sadiq ORCID: https://orcid.org/0000-0002-4042-2828, Skomorovska-Prokvolit, Yelenna, Midem, David, Ogolla, Sidney ORCID: https://orcid.org/0000-0003-1570-6164, Burckhardt, Bjoern B. ORCID: https://orcid.org/0000-0002-1782-9937, Gangnus, Tanja ORCID: https://orcid.org/0009-0005-7573-6631, Scharfstein, Julio ORCID: https://orcid.org/0000-0002-7510-7625, Caruso-Neves, Celso ORCID: https://orcid.org/0000-0002-2415-7753, McCarty, Owen J.T. ORCID: https://orcid.org/0000-0001-9481-0124, Gailani, David ORCID: https://orcid.org/0000-0001-8142-8014, Bader, Michael ORCID: https://orcid.org/0000-0003-4780-4164, Rosenthal, Phillip, Dent, Arlene E. ORCID: https://orcid.org/0000-0003-2265-7938, Janse, Chris J. ORCID: https://orcid.org/0000-0002-6410-6205, McCrae, Keith ORCID: https://orcid.org/0000-0001-7340-475X, Acacia de Sa Pinheiro, Ana, Kazura, James W. ORCID: https://orcid.org/0000-0002-6390-634X and Schmaier, Alvin H. ORCID: https://orcid.org/0000-0002-3884-6234
bioRxiv : 2026.02.23.704410. 26 February 2026

Cell surface remodeling caused by the loss of TMEM30A in immune cells.
Gurdap, Cenk O., Ragaller, Franziska, Muller, Marion, Sjule, Ellen, Sych, Taras, Blomén, Linnea, Thoren, Fredrik, Levental, Ilya, Levental, Kandice R., Sattentau, Quentin ORCID: https://orcid.org/0000-0001-7170-1937 and Sezgin, Erdinc
bioRxiv : 2026.02.21.707187. 23 February 2026

Towards crystal structures of filament forming proteins.
Roske, Yvette ORCID: https://orcid.org/0000-0001-6237-388X, Leidert, Martina, Rehbein, Kristina and Diehl, Anne ORCID: https://orcid.org/0000-0001-7295-9972
bioRxiv : 2026.02.22.707290. 22 February 2026

Extrachromosomal DNA micronucleation constrains tumour fitness and improves patient survival.
Brückner, L. ORCID: https://orcid.org/0000-0002-6155-2277, Xu, R. ORCID: https://orcid.org/0000-0002-5618-246X, Tang, J., Gnanasekar, A., Herrmann, A., Wong, I.T.L., Zhang, S., Tu, F., Pilon, M., Kukalev, A. ORCID: https://orcid.org/0000-0001-5847-3773, Pardon, K., Sidorova, O. ORCID: https://orcid.org/0009-0004-1459-1662, Atta, J., Yu, Q. ORCID: https://orcid.org/0000-0002-2151-9624, Montouri, G., Pradella, D., Ilić, M., Suina, K., Novais-Cruz, M., Kaltenbach, S., Treue, D., Giurgiu-Kraljič, M. ORCID: https://orcid.org/0000-0001-5007-7442, Herzog, S., Hollinger, A.S., Wittstruck, N., Fernandez, M., Wolozyn, N., Becker, F., Louma, V.R., Yan, X., Schmargon, R. ORCID: https://orcid.org/0009-0009-3535-7185, Dörr, J. ORCID: https://orcid.org/0000-0002-4927-6548, Gamlin, D., Lehmann, A., Gürgen, D. ORCID: https://orcid.org/0000-0001-9241-6537, Richter, M. ORCID: https://orcid.org/0000-0002-5339-0781, Dubois, F. ORCID: https://orcid.org/0000-0002-7654-6208, Simeoni, F., Pennycook, B.R., Hamilton, A., Lindemann, R.K., Dawes, C., Balmus, G., Hero, B., Fischer, M., Bafna, V., Verhaak, R., Wahl, G., Liu, Y., Koche, R.P., Papathanasiou, S., Medema, R., Spanjaard, B. ORCID: https://orcid.org/0000-0003-1309-8839, Ventura, A., Pombo, A. ORCID: https://orcid.org/0000-0002-7493-6288, Huang, W., Scheer, M., Werner, B., Chang, H.Y., Mischel, P.S. and Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X
bioRxiv : 2025.04.15.648906. 19 February 2026

Loss of cardiomyocyte eukaryotic elongation factor 1A2 in mice triggers cardiomyopathy due to defective proteostasis.
Martin-Garrido, Abel, Weyrauch, Nadine, Ruiz-Orera, Jorge ORCID: https://orcid.org/0000-0002-8317-0034, Eresch, Jeanette, Reitter, Sonja, Cordero, Julio, Senger, Frauke, Scheich, Viktoria, Grund, Andrea, Keles, Merve ORCID: https://orcid.org/0000-0002-5212-3753, Weinzierl, Nina, Hofmann, Ellen, Trogisch, Felix A., Hemanna, Shruthi, Buettner, Michael, Poschet, Gernot, Rettel, Mandy, Stein, Frank, Rog-Zielinska, Eva A., Frey, Norbert, Stoecklin, Georg, Voelkers, Mirko, Hubner, Norbert ORCID: https://orcid.org/0000-0002-1218-6223, Dobreva, Gergana ORCID: https://orcid.org/0000-0002-4814-9416 and Heineke, Joerg ORCID: https://orcid.org/0000-0002-1541-3030
bioRxiv : 2026.01.14.699518v2. 18 February 2026

c-MAF transduces fast motor neuron firing to sustain fast-glycolytic myofibers and neuromuscular junctions.
Jauliac, Edgar ORCID: https://orcid.org/0009-0007-5049-6525, Backer, Stephanie, Sadaki, Shunya, Gondin, Julien, Fessard, Aurelie, Escoffier, Hugues, Roullat, Maeva, Di Gallo, Maxime, Levesque, Adrien, Pereira, Doriane, Dos Santos, Mattieu, Vuong, Vincent, Ham, Alexander S., Letourneur, Franck, Pierre, Rémi, Rüegg, Markus A. ORCID: https://orcid.org/0000-0002-4974-9384, Birchmeier, Carmen ORCID: https://orcid.org/0000-0002-2041-8872, Fujita, Ryo, Sotiropoulos, Athanassia and Maire, Pascal ORCID: https://orcid.org/0000-0001-7795-0029
bioRxiv : 2026.02.05.703983v2. 17 February 2026

Human ADA2 deficiency is characterized by the absence of an intracellular hypoglycosylated form of adenosine deaminase 2.
Ehlers, L. ORCID: https://orcid.org/0000-0001-8737-001X, Wouters, M. ORCID: https://orcid.org/0000-0002-4675-1665, Hombrouck, A. ORCID: https://orcid.org/0009-0003-5236-6063, Pillay, B. ORCID: https://orcid.org/0000-0001-7964-544X, Delafontaine, S. ORCID: https://orcid.org/0000-0002-8985-8155, Bucciol, G. ORCID: https://orcid.org/0000-0001-5004-0738, Baggio, M. ORCID: https://orcid.org/0000-0001-6708-9925, Dzhus, M. ORCID: https://orcid.org/0000-0002-2077-4295, Francés Rabanal, E., Damerau, A. ORCID: https://orcid.org/0000-0001-6651-2963, Neugebauer, J. ORCID: https://orcid.org/0000-0002-2576-1012, Ebstein, F. ORCID: https://orcid.org/0000-0002-3729-7878, Jacquemyn, M. ORCID: https://orcid.org/0000-0003-2626-4189, De Somer, L. ORCID: https://orcid.org/0000-0002-8488-5090, Schrijvers, R. ORCID: https://orcid.org/0000-0002-4261-6220, Vanderschueren, S. ORCID: https://orcid.org/0000-0002-4003-5465, Cassiman, D. ORCID: https://orcid.org/0000-0002-6154-0970, Kirchner, M. ORCID: https://orcid.org/0000-0002-7049-534X, Mertins, P. ORCID: https://orcid.org/0000-0002-2245-528X, Mashreghi, M.F., Kallinich, T. ORCID: https://orcid.org/0000-0003-2404-9397, Daelemans, D. ORCID: https://orcid.org/0000-0001-7092-1153, Agostinis, P. ORCID: https://orcid.org/0000-0003-1314-2115, Moens, L. ORCID: https://orcid.org/0000-0002-5347-6526 and Meyts, I. ORCID: https://orcid.org/0000-0003-1214-0302
bioRxiv : 2023.10.25.564037. 16 February 2026

Multi-omics insight into cardiac myofibril remodeling in post-prandial burmese pythons.
Martin, Thomas G. ORCID: https://orcid.org/0000-0002-1300-4890, Suarez-Artiles, Lorena ORCID: https://orcid.org/0000-0001-7991-5446, Woulfe, Kathleen C., Melhedegaard, Elise G., Tan, Yuxiao, Hunt, Dakota R., Kirkpatrick, Bruce E., Nguyen, Lia, Lee, Joseph, Laskey, Isabella, Anseth, Kristi S., Ochala, Julien, Gotthardt, Michael ORCID: https://orcid.org/0000-0003-1788-3172, Mertins, Philipp ORCID: https://orcid.org/0000-0002-2245-528X and Leinwand, Leslie A. ORCID: https://orcid.org/0000-0003-1470-4810
bioRxiv : 2026.02.02.703272. 4 February 2026

Flexibility of cell fates and functions across sex determination systems revealed by comparative single-cell analyses.
Acemel, Rafael D. ORCID: https://orcid.org/0000-0003-4120-0140, Tezak, Boris ORCID: https://orcid.org/0000-0002-2621-4272, Chung, Vicky Wai Yee, Hurtado, Alicia ORCID: https://orcid.org/0000-0001-6267-704X, Albertson, Scarlett, Weber, Ceri J. ORCID: https://orcid.org/0000-0001-8541-0110, Capel, Blanche ORCID: https://orcid.org/0000-0002-6587-0969 and Lupiáñez, Darío G. ORCID: https://orcid.org/0000-0002-3165-036X
bioRxiv : 2026.01.29.701242. 30 January 2026

Integrative modelling reveals the structure of the human Mic60-Mic19 subcomplex and its role as a diffusion barrier in mitochondria.
Nathanail, Evangelia ORCID: https://orcid.org/0009-0004-9579-8074, Rolando, Edoardo ORCID: https://orcid.org/0009-0001-8276-1406, Ruwolt, Max ORCID: https://orcid.org/0009-0000-7220-406X, Zaporozhets, Iryna, Liu, Fan ORCID: https://orcid.org/0000-0002-2358-549X, Clementi, Cecilia ORCID: https://orcid.org/0000-0001-9221-2358 and Daumke, Oliver ORCID: https://orcid.org/0000-0002-6190-1414
bioRxiv : 2026.01.30.702776. 30 January 2026

Integrating UHPLC-MS and MALDI-MSI for spatial nucleoside profiling in FFPE breast cancer: a multimodal molecular pathology framework.
Wu, Jierong ORCID: https://orcid.org/0000-0002-2413-0411, Geisberger, Sabrina Y. ORCID: https://orcid.org/0000-0001-6477-1312, Mastrobuoni, Guido ORCID: https://orcid.org/0000-0003-4509-1295, Lisek, Kamil ORCID: https://orcid.org/0000-0002-2406-8830, Raimundo, Sandra ORCID: https://orcid.org/0009-0000-3353-5456, Nebrich, Grit, Grzeski, Marta, Rajewsky, Nikolaus ORCID: https://orcid.org/0000-0002-4785-4332, Klauschen, Frederick ORCID: https://orcid.org/0000-0002-9131-2389, Klein, Oliver ORCID: https://orcid.org/0000-0001-7984-7607 and Kempa, Stefan ORCID: https://orcid.org/0000-0002-0696-9299
bioRxiv : 2026.01.28.701949. 30 January 2026

Human T cells from resistant hypertension patients promote hypertension via TNF in humanized mice.
Rahman, Masudur, Bartolomaeus, Hendrik ORCID: https://orcid.org/0000-0003-4288-3828, Hering, Lydia, Yakoub, Mina ORCID: https://orcid.org/0009-0002-3405-2864, Yang, Guang ORCID: https://orcid.org/0000-0001-5271-7079, Holle, Johannes ORCID: https://orcid.org/0000-0001-8032-4096, Streese, Lukas, Arifaj, Denada ORCID: https://orcid.org/0009-0004-2759-6999, Hahn, Milena, Müller, Marta, Grüner, Tim Felix, Meister, Jaroslawna ORCID: https://orcid.org/0000-0003-4634-1815, Wilck, Nicola ORCID: https://orcid.org/0000-0003-3189-5364, Kleinewietfeld, Markus ORCID: https://orcid.org/0000-0002-2832-3149, Rump, Lars Christian, Müller, Dominik N. ORCID: https://orcid.org/0000-0003-3650-5644, Temme, Sebastian and Stegbauer, Johannes ORCID: https://orcid.org/0000-0001-8994-8102
bioRxiv : 2026.01.23.701431. 25 January 2026

TENM4 is an essential transduction component for touch.
Khallaf, Mohammed A. ORCID: https://orcid.org/0000-0002-1402-3858, Huang, Angela Tzu-Lun ORCID: https://orcid.org/0000-0003-3471-192X, Dalmasso, Letizia, Chakrabarti, Sampurna ORCID: https://orcid.org/0000-0002-2750-3877, Groeneveld, Rowena ORCID: https://orcid.org/0009-0009-1898-9957, Sierra, Yinth Andrea Bernal, Garcia-Contreras, Jonathan Alexis, Nello, Emilie ORCID: https://orcid.org/0009-0001-3622-9849, Schütz, Anja ORCID: https://orcid.org/0000-0002-0606-2574, Bégay, Valérie ORCID: https://orcid.org/0000-0002-9002-4211, Santuz, Alessandro ORCID: https://orcid.org/0000-0002-6577-5101, Hedtrich, Sarah ORCID: https://orcid.org/0000-0001-6770-3657, Zhong, Wei, Schiel, Christina, Middleton, Steven J. ORCID: https://orcid.org/0000-0002-0708-7335, Popp, Oliver ORCID: https://orcid.org/0000-0001-6240-4666, Zampieri, Niccolò ORCID: https://orcid.org/0000-0002-2228-9453, Mertins, Philipp ORCID: https://orcid.org/0000-0002-2245-528X, Kunz, Severine ORCID: https://orcid.org/0000-0002-0131-3506 and Lewin, Gary R. ORCID: https://orcid.org/0000-0002-2890-6352
bioRxiv : 2024.10.10.617546v2. 18 January 2026

OpenDVP: an experimental and computational framework for community-empowered deep visual proteomics.
Nimo, Jose ORCID: https://orcid.org/0000-0002-1565-7799, Fritzsche, Sonja ORCID: https://orcid.org/0000-0003-3335-3534, Valdes, Daniela S. ORCID: https://orcid.org/0000-0002-1309-5147, Trinh, Minh Tien ORCID: https://orcid.org/0009-0000-2727-8449, Pentimalli, Tancredi ORCID: https://orcid.org/0000-0002-8461-7918, Klingeberg, Melissa ORCID: https://orcid.org/0009-0002-4778-2874, Schallenberg, Simon ORCID: https://orcid.org/0000-0002-7897-7116, Klauschen, Frederick ORCID: https://orcid.org/0000-0002-9131-2389, Herse, Florian ORCID: https://orcid.org/0000-0002-9305-8134, Florian, Stefan ORCID: https://orcid.org/0000-0002-0193-1320, Rajewsky, Nikolaus ORCID: https://orcid.org/0000-0002-4785-4332 and Coscia, Fabian ORCID: https://orcid.org/0000-0002-2244-5081
bioRxiv : 2025.07.13.662099v2. 15 January 2026

Selective class IIa HDAC inhibition reverses diastolic dysfunction in cardiometabolic HFpEF.
Huang, Jiale, Schreiter, Friederike, Fan, Junyu, Chen, Zihao, Paluvai, Harikrishnareddy, Withaar, Coenraad, Oeing, Christian U., Saadatmand, Ali Reza, Schoger, Eric ORCID: https://orcid.org/0000-0002-5485-9828, Haydar, Shaza, Elsherbiny, Adel, Hagenmüller, Marco, Lapouge, Karine, Guimarães-Camboa, Nuno, Falcão-Pires, Inês, Hamdani, Nazha, Schulze, Almut, Jansen, Sepp, Nolan, Michael A., Gilsbach, Ralf, de Boer, Rudolf A., Dewenter, Matthias and Backs, Johannes ORCID: https://orcid.org/0000-0002-2322-2699
bioRxiv : 2026.01.14.699428. 14 January 2026

HDAC inhibition via suberoylanilide hydroxamic acid (SAHA) ameliorates Doxorubicin-induced cardiotoxicity.
Eksi, Benay, Finke, Daniel, Michel, Synje, Brauer, Jannek, Heckmann, Markus B., Valadan, Mohsen, Schanze, Leonard M., Sunder, Vighnesh, Katus, Hugo A., Frey, Norbert, Backs, Johannes ORCID: https://orcid.org/0000-0002-2322-2699 and Lehmann, Lorenz H.
bioRxiv : 2026.01.12.698976. 12 January 2026

Platelet C5aR1 aggravates myocardial infarction through platelet–neutrophil interactions and CXCL4-dependent NET release.
Schommer, Nicolas ORCID: https://orcid.org/0000-0001-9568-9426, Zhang, Shanshan, Nording, Henry ORCID: https://orcid.org/0000-0003-2784-8573, Sauter, Manuela ORCID: https://orcid.org/0000-0002-6411-5697, von Esebeck, Jacob ORCID: https://orcid.org/0009-0000-3813-0423, Schilf, Paul ORCID: https://orcid.org/0000-0003-3015-656X, Sadik, Christian D. ORCID: https://orcid.org/0000-0001-6701-048X, Schanze, Nancy ORCID: https://orcid.org/0000-0002-4012-103X, Gauchel, Nadine ORCID: https://orcid.org/0000-0002-1276-9920, Hamad, Muataz Ali ORCID: https://orcid.org/0009-0009-8298-0500, Krauel, Krystin ORCID: https://orcid.org/0000-0002-2030-1332, Burkhard, Niklas ORCID: https://orcid.org/0000-0002-8435-0301, Heger, Lukas A. ORCID: https://orcid.org/0000-0002-9419-5675, Langer, Harald F. ORCID: https://orcid.org/0000-0003-2224-0518 and Duerschmied, Daniel ORCID: https://orcid.org/0000-0001-5249-4012
bioRxiv : 2026.01.12.699090. 12 January 2026

Complex human hear bearing skin organoids reveal cell type specific susceptibility and innate immune responses to Herpes Simplex Virus 1.
Wyler, Emanuel ORCID: https://orcid.org/0000-0002-9884-1806, Albertini, Silvia ORCID: https://orcid.org/0000-0002-8540-5378, Friedel, Caroline C. ORCID: https://orcid.org/0000-0003-3569-4877, Manukyan, Artür ORCID: https://orcid.org/0000-0002-0441-9517, Winterfeldt, Annalena, Bracker, Nina, Huang, Jiabin ORCID: https://orcid.org/0000-0002-3480-7115, Krasemann, Susanne ORCID: https://orcid.org/0000-0001-8795-818X, Plumbon, Izabela ORCID: https://orcid.org/0009-0006-3720-3700, Altmüller, Janine ORCID: https://orcid.org/0000-0003-4372-1521, Conrad, Thomas ORCID: https://orcid.org/0000-0001-5618-6295, Reimer, Rudolph, Schneider, Carola, Radbruch, Helena ORCID: https://orcid.org/0000-0001-6941-3397, Hafezi, Wali, Hansen, Arne, Grundhoff, Adam ORCID: https://orcid.org/0000-0003-0940-7045, Landthaler, Markus ORCID: https://orcid.org/0000-0002-1075-8734, Fischer, Nicole ORCID: https://orcid.org/0000-0002-5092-8179 and Czech-Sioli, Manja ORCID: https://orcid.org/0000-0002-7720-3282
bioRxiv : 2025.02.10.637415v2. 12 January 2026

Design of combination therapeutics from protein response to drugs in ovarian cancer cells.
Franz, A., Shen, C., Coscia, F. ORCID: https://orcid.org/0000-0002-2244-5081, Munroe, K., Charaoui, L., Korkut, A. ORCID: https://orcid.org/0000-0001-8072-9026, Mann, M. ORCID: https://orcid.org/0000-0003-1292-4799, Luna, A. ORCID: https://orcid.org/0000-0001-5709-371X and Sander, C. ORCID: https://orcid.org/0000-0001-6059-6270
bioRxiv : 2025.04.28.651139. 8 January 2026

Structural studies suggest CCDC127 as a novel membrane contact site protein in the mitochondrial intermembrane space.
Bock-Bierbaum, Tobias ORCID: https://orcid.org/0000-0003-0843-2716, von der Malsburg, Karina, Natarajan, Ashwin Karthick ORCID: https://orcid.org/0000-0001-7897-708X, Zarges, Christine, Akkaya, Kerem Can, Aladawi, Amjad, Noll, Katja, Jungbluth, Sibylle, Schirra, Claudia, Zhu, Ying, Cremer, Nils, Bernert, Carola, Liu, Fan ORCID: https://orcid.org/0000-0002-2358-549X, Lehmann, Martin ORCID: https://orcid.org/0000-0002-8370-6353, Riemer, Jan ORCID: https://orcid.org/0000-0002-7574-8457, van der Laan, Martin ORCID: https://orcid.org/0000-0003-0789-9912 and Daumke, Oliver ORCID: https://orcid.org/0000-0002-6190-1414
bioRxiv : 2025.12.11.693622. 16 December 2025

Genomic G quadruplexes regulate mRNA splicing.
Mauz, Victoria, Britto-Borges, Thiago ORCID: https://orcid.org/0000-0002-6218-4429, Merkel, Tobias, Gjerga, Enio, Hartmann, Joshua, Snaebjörnsson, Marteinn Thor, Schreiter, Friederike, Oeing, Christian U., Sticht, Carsten, Sossalla, Samuel, Okun, Jürgen Günther, Stoecklin, Georg, Hentze, Matthias W., Furlong, Eileen E.M., Schulze, Almut, Dewenter, Matthias, Dieterich, Christoph and Backs, Johannes ORCID: https://orcid.org/0000-0002-2322-2699
bioRxiv : 2025.12.15.693900. 16 December 2025

Topology control by a conserved cysteine pair in the OMM-protein CCDC127 enables MICOS interaction.
Zarges, Christine, Schepsky, Pauline, Rothemann, Robin Alexander, Bock-Bierbaum, Tobias ORCID: https://orcid.org/0000-0003-0843-2716, von der Malsburg, Alexander, Baumann, Linda, Trifunovic, Aleksandra ORCID: https://orcid.org/0000-0002-5472-3517, Daumke, Oliver ORCID: https://orcid.org/0000-0002-6190-1414, van der Laan, Martin ORCID: https://orcid.org/0000-0003-0789-9912, von der Malsburg, Karina and Riemer, Jan ORCID: https://orcid.org/0000-0002-7574-8457
bioRxiv : 2025.12.12.693940. 15 December 2025

Multi-omics analysis reveals vitamin D metabolism, hyper-IgE genes, and epithelial barrier dysfunction in hazelnut allergy.
Jeanrenaud, Alexander C.S.N. ORCID: https://orcid.org/0000-0002-4230-9976, Arnau-Soler, Aleix ORCID: https://orcid.org/0000-0001-9768-0513, Ghauri, Ahla ORCID: https://orcid.org/0000-0003-4665-3624, Marenholz, Ingo ORCID: https://orcid.org/0009-0007-6933-3849, Mertins, Philipp ORCID: https://orcid.org/0000-0002-2245-528X, Beyer, Kirsten ORCID: https://orcid.org/0000-0003-1859-0419, Worm, Margitta ORCID: https://orcid.org/0000-0002-3449-1245 and Lee, Young-Ae ORCID: https://orcid.org/0000-0002-1817-9163
bioRxiv : 2025.12.11.692994. 13 December 2025

Anthropogenic land use exerts selection pressures on the resistome of a wild rodent.
Gicquel, M. ORCID: https://orcid.org/0000-0002-0823-1239, Planillo, A. ORCID: https://orcid.org/0000-0001-6763-9923, Heitlinger, E. ORCID: https://orcid.org/0000-0002-7139-3425, Forslund-Startceva, S.K. ORCID: https://orcid.org/0000-0003-4285-6993, Kramer-Schadt, S. ORCID: https://orcid.org/0000-0002-9269-4446, Ferreira, S.C.M. ORCID: https://orcid.org/0000-0003-0265-0210 and Jarquín-Díaz, V.H. ORCID: https://orcid.org/0000-0003-3758-1091
bioRxiv : 2025.12.12.693898. 12 December 2025

Global analysis of infant gut microbiota revealed distinctive maturation dynamics across lifestyles.
Bücking, Robert ORCID: https://orcid.org/0000-0002-0180-5551, Pasquali, Greta, Löber, Ulrike ORCID: https://orcid.org/0000-0001-7468-9531, Buss, Claudia ORCID: https://orcid.org/0000-0002-8738-3133, Viemann, Dorothee ORCID: https://orcid.org/0000-0002-9009-3559, Jarquín-Díaz, Víctor Hugo ORCID: https://orcid.org/0000-0003-3758-1091 and Forslund-Startceva, Sofia Kirke ORCID: https://orcid.org/0000-0003-4285-6993
bioRxiv : 2025.12.11.693638. 11 December 2025

A human missense variant in BSX decouples circadian behaviour from metabolic rhythmicity while preserving lifespan in mice.
Treier, Anna-Corina ORCID: https://orcid.org/0000-0003-1309-6446, Klasen, Christian, Kramer, Madlen, Schmidt, Deborah ORCID: https://orcid.org/0000-0002-8621-9438, Block, Franziska, Gebhardt, Janine, Rusak, Fabio Rojas ORCID: https://orcid.org/0000-0002-0637-9467, Farooqi, I. Sadaf ORCID: https://orcid.org/0000-0001-7609-3504 and Treier, Mathias ORCID: https://orcid.org/0000-0002-8751-1246
bioRxiv : 2025.12.05.692520. 9 December 2025

IgLON5 autoimmune antibodies activate Tau via neuronal hyperactivity.
Askin, B., Kilic, C., Cordero Gómez, C., Duong, S.L.L., Domingues-Baquero, A., Goihl, A., Nalbach, K., Petuschi, J., Grundschöttel, P., Wagner, J., Thomas, V., Lamberty, J., Withers, E., Huber, H., Huebschmann, S., Semenova, E., Turko, P., Newman, A.G. ORCID: https://orcid.org/0000-0002-0222-9162, Diez, L. ORCID: https://orcid.org/0000-0003-3101-0191, De Domenico, E., Körtvelyessy, P. ORCID: https://orcid.org/0000-0003-1262-6169, Reinhold, D., Schneider, A., Neher, J.J., Ulas, T., Lichtenthaler, S.F., Rost, B.R., Schmitz, D. ORCID: https://orcid.org/0000-0003-2741-5241, Prüss, H. ORCID: https://orcid.org/0000-0002-8283-7976 and Wegmann, S. ORCID: https://orcid.org/0000-0002-5388-2479
bioRxiv : 2024.03.10.584272v2. 5 December 2025

StemCNV-check: a pipeline for human pluripotent stem cell (hPSC) genomic integrity control using SNP array data and copy number variant scoring.
von Kuegelgen, Nicolai ORCID: https://orcid.org/0000-0001-8116-9032, Fernandez Vallone, Valeria, Ludwik, Katarzyna A. ORCID: https://orcid.org/0000-0002-9436-7270, Babaeva, Mariia, Diecke, Sebastian ORCID: https://orcid.org/0000-0002-5219-5992, Beule, Dieter ORCID: https://orcid.org/0000-0002-3284-0632 and Stachelscheid, Harald
bioRxiv : 2025.12.01.691615. 3 December 2025

Calbindin-containing CA1 pyramidal cells support cognitive flexibility in spatial task in mice.
Voigt, Anne ORCID: https://orcid.org/0009-0006-0360-2463, Metodieva, Verjinia D., Alevi, Denis ORCID: https://orcid.org/0000-0001-8514-7199, Tukker, John J. ORCID: https://orcid.org/0000-0002-4394-199X, Stumpf, Alexander, Parthier, Daniel ORCID: https://orcid.org/0000-0001-8775-024X and Schmitz, Dietmar ORCID: https://orcid.org/0000-0003-2741-5241
bioRxiv : 2025.11.30.691413. 2 December 2025

Butyrate rescues cardiac metabolic dysfunction in hypertensive heart failure with preserved ejection fraction.
Kedziora, Sarah M. ORCID: https://orcid.org/0000-0003-0124-2557, Geisberger, Sabrina Y. ORCID: https://orcid.org/0000-0001-6477-1312, Popp, Oliver ORCID: https://orcid.org/0000-0001-6240-4666, Frolova, Alina ORCID: https://orcid.org/0000-0001-5469-7366, Uhrbach, Alisa, Kräker, Kristin ORCID: https://orcid.org/0000-0002-4032-5382, Tagiyeva, Nurana ORCID: https://orcid.org/0009-0006-7918-1220, Kelm, Marcus, Berndt, Nikolaus, Zhang, Yiming D. ORCID: https://orcid.org/0009-0003-9465-2033, Mastrobuoni, Guido ORCID: https://orcid.org/0000-0003-4509-1295, Escrihuela-Branz, Raquel, Bartolomaeus, Theda U.P. ORCID: https://orcid.org/0000-0002-5156-7184, Pixner, Lorenz, Fahjen, Pauline ORCID: https://orcid.org/0000-0002-5015-0643, Kaufhold, Gelsomina N. ORCID: https://orcid.org/0009-0009-0868-3284, Parakkat, Pragati ORCID: https://orcid.org/0000-0003-2691-791X, Chitroceanu, Alexandra Maria, Tschöpe, Carsten, Edelmann, Frank, Schiattarella, Gabriele G. ORCID: https://orcid.org/0000-0002-7582-7171, Forslund, Sofia K. ORCID: https://orcid.org/0000-0003-4285-6993, Wilck, Nicola ORCID: https://orcid.org/0000-0003-3189-5364, Gotthardt, Michael ORCID: https://orcid.org/0000-0003-1788-3172, Mertins, Philipp ORCID: https://orcid.org/0000-0002-2245-528X, Dechend, Ralf ORCID: https://orcid.org/0000-0001-6636-3080, Sawamiphak, Suphansa ORCID: https://orcid.org/0000-0003-2298-3565, Müller, Dominik N. ORCID: https://orcid.org/0000-0003-3650-5644, Kempa, Stefan ORCID: https://orcid.org/0000-0002-0696-9299 and Haase, Nadine ORCID: https://orcid.org/0000-0003-0727-1738
bioRxiv : 2025.11.28.690152. 30 November 2025

Disrupted endothelial cell-cell dynamics in ALK1 and SMAD4 deficiency drive arteriovenous malformations.
Hardman, David ORCID: https://orcid.org/0000-0001-9903-4443, Oppenheim, Olya ORCID: https://orcid.org/0000-0002-5299-3193, Giese, Wolfgang ORCID: https://orcid.org/0000-0003-0872-0929, Gerhardt, Holger ORCID: https://orcid.org/0000-0002-3030-0384 and Bernabeu, Miguel Oscar ORCID: https://orcid.org/0000-0002-6456-3756
bioRxiv : 2025.11.26.690643. 29 November 2025

Ferroptosis governs lymphatic vessel growth and regression.
Drekolia, Maria-Kyriaki, Wang, Daiyu, Chen, Yunyun, Du, Yali, Wittig, Janina, Xu, Ran, Schilling, Danny, Aliraj, Blerina, Mettner, Janina, Gupta, Lavanya, Xu, Cong, Günther, Stefan, Cetin, Ronay, Matthess, Yves, Fleming, Ingrid, Kaulich, Manuel ORCID: https://orcid.org/0000-0002-9528-8822, Dobreva, Gergana ORCID: https://orcid.org/0000-0002-4814-9416, Weigert, Andreas, Dick, Tobias P., Dikic, Ivan, Stolz, Alexandra ORCID: https://orcid.org/0000-0002-3340-439X, Yaniv, Karina ORCID: https://orcid.org/0000-0001-5638-7150, Linkermann, Andreas, Hu, Jiong and Bibli, Sofia-Iris ORCID: https://orcid.org/0000-0001-7153-6628
bioRxiv : 2025.11.18.689033. 24 November 2025

Myeloid cell recruitment propels right ventricular dysfunction in HFpEF via sterile inflammation.
Jaeschke, Lara ORCID: https://orcid.org/0009-0004-1847-5378, Kocana, Ceren, Chitroceanu, Alexandra Maria, Winkler, Annika, Kleitke, Hannah, Fahjen, Pauline ORCID: https://orcid.org/0000-0002-5015-0643, Faidel, David ORCID: https://orcid.org/0000-0001-9606-9595, Asmus, Erik ORCID: https://orcid.org/0000-0003-4740-7724, Meiser, Martin, Stamatiades, Efstathios G., Hublitz, Karolin W, Zach, Veronika, Kretzler, Lucie, Zurkan, Daniela, Perret, Paul-Lennard, von der Ohe, Leonardo Axel, Simmons, Szandor ORCID: https://orcid.org/0000-0002-5309-9863, Gillan, Jonathan L. ORCID: https://orcid.org/0000-0002-9017-253X, Franz, Kristina ORCID: https://orcid.org/0000-0002-3819-9671, Alasfar, Lina, Hahn, Virginia Shalkey ORCID: https://orcid.org/0000-0002-0578-2668, Sharma, Kavita ORCID: https://orcid.org/0000-0002-3012-1765, Reynolds, Edwardo, Schiattarella, Gabriele G. ORCID: https://orcid.org/0000-0002-7582-7171, Van Linthout, Sophie ORCID: https://orcid.org/0000-0002-7581-7870, Pieske, Burkert ORCID: https://orcid.org/0000-0002-6466-5306, Hegemann, Niklas ORCID: https://orcid.org/0000-0002-2898-0798, Mertins, Philipp ORCID: https://orcid.org/0000-0002-2245-528X, Edelmann, Frank, Kuebler, Wolfgang M. ORCID: https://orcid.org/0000-0003-4100-2961 and Grune, Jana ORCID: https://orcid.org/0000-0001-6209-7416
bioRxiv : 2025.11.21.689863. 23 November 2025

Interleukin enhancer binding factor 2 (Ilf2) and kidney epithelial stress resilience.
Cao, Shuang ORCID: https://orcid.org/0000-0001-7195-8193, López-Cayuqueo, Karen I. ORCID: https://orcid.org/0000-0001-8409-7345, Leiz, Janna ORCID: https://orcid.org/0000-0002-6531-7047, Boivin, Felix J. ORCID: https://orcid.org/0000-0003-2325-0830, Markó, Lajos ORCID: https://orcid.org/0000-0003-1888-5575, Hinze, Christian ORCID: https://orcid.org/0000-0003-2526-1621, Schmitz, Jessica, Bräsen, Jan Hinrich and Schmidt-Ott, Kai ORCID: https://orcid.org/0000-0002-7700-7142
bioRxiv : 2025.08.12.667599v3. 21 November 2025

Interleukin-17A mediates cardiorenal injury in oxalate nephropathy.
Wimmer, Moritz I. ORCID: https://orcid.org/0009-0004-5793-0249, Reichel, Martin ORCID: https://orcid.org/0000-0001-7886-2784, Thiele, Arne ORCID: https://orcid.org/0000-0003-0786-2239, Yarritu, Alex ORCID: https://orcid.org/0000-0002-1724-0559, Matz-Rauch, Ariana ORCID: https://orcid.org/0000-0002-5152-5830, Anandakumar, Harithaa ORCID: https://orcid.org/0009-0000-3326-5126, Götz, Luisa Hernandez ORCID: https://orcid.org/0009-0001-0560-1548, Lesker, Till Robin ORCID: https://orcid.org/0000-0002-3085-6438, Potapenko, Olena ORCID: https://orcid.org/0000-0002-4397-568X, Gebremedhin, Natnael ORCID: https://orcid.org/0009-0001-2250-9436, Anders, Wibke ORCID: https://orcid.org/0009-0000-6069-4233, Liévano Contreras, Sarah V. ORCID: https://orcid.org/0009-0000-9967-0108, Wang, Rongling ORCID: https://orcid.org/0000-0001-8719-938X, Nonn, Olivia ORCID: https://orcid.org/0000-0001-6385-2866, Schiattarella, Gabriele G. ORCID: https://orcid.org/0000-0002-7582-7171, Schaefer, Franz ORCID: https://orcid.org/0000-0001-7564-9937, Holle, Johannes ORCID: https://orcid.org/0000-0001-8032-4096, Strowig, Till ORCID: https://orcid.org/0000-0003-0185-1459, Zernecke, Alma ORCID: https://orcid.org/0000-0001-8551-4729, Eckardt, Kai-Uwe ORCID: https://orcid.org/0000-0003-3823-0920, Knauf, Felix ORCID: https://orcid.org/0000-0001-5762-1404, Wilck, Nicola ORCID: https://orcid.org/0000-0003-3189-5364 and Bartolomaeus, Hendrik ORCID: https://orcid.org/0000-0003-4288-3828
bioRxiv : 2025.11.17.687153. 18 November 2025

BIRC5 dependency defines a targetable vulnerability in TP53 mutant acute myeloid leukemia.
Mamdouh, Ahmed M., Lim, Fang Qi, Mi, Yang, Olesinski, Elyse A., Jasdanwala, Shaista, Lin, Xiao Xian, Ayoub, Edward, Tan, Jordan Yong Ming, Bhatia, Karanpreet Singh, Wang, Yichen, Garnaik, Shradha, Tomar, Kunal, Sapozhnikova, Valeriia, Chan, Cheryl Gek Teng, Wang, Chuqi, Mahesh, Aarthi Nivasini, Mertins, Philipp ORCID: https://orcid.org/0000-0002-2245-528X, Brown, Brandon D., Haferlach, Torsten, Ooi, Melissa, Lobry, Camille, Puissant, Alexandre, Taylor, Justin, Abbas, Hussein, Kornblau, Steven M., Miller, Peter G., Das, Sanjukta, Krönke, Jan, Itahana, Koji, Andreeff, Michael and Bhatt, Shruti
bioRxiv : 2025.05.17.654633v2. 15 November 2025

Paw posture is a robust indicator for injury, pain, and age.
Pritz, Christian Oliver ORCID: https://orcid.org/0009-0002-3227-0630, Dotta, Sofia ORCID: https://orcid.org/0009-0006-3647-5480, Freund, Philip Alexander ORCID: https://orcid.org/0000-0003-0021-3850, Musso, Giada ORCID: https://orcid.org/0009-0002-3713-4910, Bader, Michael ORCID: https://orcid.org/0000-0003-4780-4164, Okladnikov, Nataliya ORCID: https://orcid.org/0000-0002-7429-5644, Rother, Franziska ORCID: https://orcid.org/0000-0002-4417-2192 and Marvaldi, Letizia ORCID: https://orcid.org/0000-0002-2021-3949
bioRxiv : 2025.11.13.688005. 13 November 2025

The cortical microenvironment drives early immune organization and controls early osteoclastogenesis in bone healing.
Noom, Anne ORCID: https://orcid.org/0009-0006-8589-5350, Oktay, Hulya Zeynep ORCID: https://orcid.org/0000-0002-1333-2122, Morgan, Duncan M. ORCID: https://orcid.org/0000-0002-3253-1362, Kroh, Sandy ORCID: https://orcid.org/0000-0002-3736-3361, Ellinghaus, Agnes, Kochan, Merle, Bolaji, Olufemi A., Uecker, Ralf, Guenther, Robert, Bucher, Christian H. ORCID: https://orcid.org/0000-0002-3900-088X, Triantafyllopoulou, Antigoni ORCID: https://orcid.org/0000-0003-0123-7117, Haas, Simon ORCID: https://orcid.org/0000-0001-9227-2051, Schmidt-Bleek, Katharina ORCID: https://orcid.org/0000-0002-5719-0867, Hauser, Anja E. ORCID: https://orcid.org/0000-0002-7725-9526, Sawitzki, Birgit ORCID: https://orcid.org/0000-0001-8166-8579 and Duda, Georg N. ORCID: https://orcid.org/0000-0001-7605-3908
bioRxiv : 2025.11.03.684298. 4 November 2025

Kidney-specific Wdr72 deletion leads to incomplete distal renal tubular acidosis through impaired V-ATPase B1 subunit localization.
Al-Shebel, Amr ORCID: https://orcid.org/0000-0001-7459-3839, Mossmann, Phoebe, Wendlinger, Sarah ORCID: https://orcid.org/0000-0001-6771-4794, Breiderhoff, Tilman ORCID: https://orcid.org/0000-0002-1676-7498, Kaminski, Michael M. ORCID: https://orcid.org/0000-0003-0429-7027, Müller, Dominik ORCID: https://orcid.org/0000-0002-3478-1576, Bufler, Philip ORCID: https://orcid.org/0000-0002-5742-8273 and Klämbt, Verena ORCID: https://orcid.org/0000-0003-1180-0794
bioRxiv : 2025.10.29.684588v2. 3 November 2025

Evolutionarily conserved transcriptional regulators control monoaminergic neuron development.
Lewis, Clifton ORCID: https://orcid.org/0000-0002-3077-8150, Goulty, Matthew ORCID: https://orcid.org/0009-0001-5731-6722, Wroblewska, Aniela, Croxall, Nicola ORCID: https://orcid.org/0009-0003-1061-6909, Onion, David ORCID: https://orcid.org/0000-0002-4522-2307, Robinson, Sue, Zinzen, Robert P. ORCID: https://orcid.org/0000-0002-8638-5102, Solana, Jordi ORCID: https://orcid.org/0000-0002-6770-3929, Kyriacou, Charalambos P. ORCID: https://orcid.org/0000-0003-4889-7606, Rosato, Ezio ORCID: https://orcid.org/0000-0001-7297-4697 and Feuda, Roberto ORCID: https://orcid.org/0000-0003-0857-1732
bioRxiv : 2025.10.29.685200v2. 31 October 2025

Guided maturation of human neuromuscular organoids via electrical stimulation.
Moysidou, Chrysanthi-Maria ORCID: https://orcid.org/0000-0001-9809-2764, Afonso Martins, Inês ORCID: https://orcid.org/0009-0007-6147-2975, El-Shimy, Ismail Amr ORCID: https://orcid.org/0000-0003-0587-5140, Cea, Donatella, Bukas, Christina, Mekki, Isra, Lahmann, Ines ORCID: https://orcid.org/0000-0003-0640-4519, Piraud, Marie, Klotzsch, Enrico and Gouti, Mina ORCID: https://orcid.org/0000-0001-7422-1605
bioRxiv : 2025.10.30.685366. 31 October 2025

Cryo-EM structure of the naked mole-rat ribosome reveals a stabilized split 28S rRNA.
Gül, Mehmet ORCID: https://orcid.org/0000-0001-5513-1866, Rossi, Alice ORCID: https://orcid.org/0000-0002-8819-9813, Spahn, Christian M.T. ORCID: https://orcid.org/0000-0002-2939-9487, Lewin, Gary R. ORCID: https://orcid.org/0000-0002-2890-6352 and Kudryashev, Mikhail ORCID: https://orcid.org/0000-0003-3550-6274
bioRxiv : 2025.10.26.684699. 27 October 2025

Self-organized vascularized human liver spheroids: Serum-free culture conditions and use as tissue building blocks.
Filatova, Alina ORCID: https://orcid.org/0000-0002-2731-1963, Valentirovic Dann, Olivera, Schwarzkopf, Jennifer Bianca ORCID: https://orcid.org/0000-0001-9552-0794, Gerhardus, Jamina Sofie ORCID: https://orcid.org/0000-0001-6771-4145, Kaysan, Leon, Blaeser, Andreas, Straub, Beate Katharina, Gerhardt, Holger ORCID: https://orcid.org/0000-0002-3030-0384 and Nuber, Ulrike A.
bioRxiv : 2025.10.25.684548. 26 October 2025

Similar fecal SCFA patterns despite diverse gut microbiota in Polish and Japanese children during the first two years of life. The longitudinal, comparative, validated study.
Łoniewski, Igor ORCID: https://orcid.org/0000-0002-5398-4985, Kaczmarczyk, Mariusz ORCID: https://orcid.org/0000-0002-0180-644X, Podsiadło, Konrad ORCID: https://orcid.org/0000-0002-4061-2103, Cembrowska-Lech, Danuta ORCID: https://orcid.org/0000-0002-1503-0064, Löber, Ulrike ORCID: https://orcid.org/0000-0001-7468-9531, Bücking, Robert ORCID: https://orcid.org/0000-0002-0180-5551, Skonieczna-Żydecka, Karolina ORCID: https://orcid.org/0000-0002-3430-9079, Forslund-Startceva, Sofia Kirke ORCID: https://orcid.org/0000-0003-4285-6993 and Łoniewska, Beata ORCID: https://orcid.org/0000-0002-0482-9014
bioRxiv : 2025.10.23.684084. 23 October 2025

Gene-specific endothelial programs drive AVM pathogenesis in SMAD4 and ALK1 loss-of-function.
Oppenheim, O. ORCID: https://orcid.org/0000-0002-5299-3193, Giese, W. ORCID: https://orcid.org/0000-0003-0872-0929, Park, H. ORCID: https://orcid.org/0000-0002-3671-8618, Baumann, E. ORCID: https://orcid.org/0000-0002-7804-4885, Ivanov, A. ORCID: https://orcid.org/0000-0002-4824-1925, Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Eichmann, A. ORCID: https://orcid.org/0000-0001-5563-210X and Gerhardt, H. ORCID: https://orcid.org/0000-0002-3030-0384
bioRxiv : 2025.01.03.631070v3. 18 October 2025

CAMK2-NR4A1 signaling initiates metabolic substrate switching to induce heart failure with reduced ejection fraction.
Saadatmand, Alireza, Pepin, Mark ORCID: https://orcid.org/0000-0003-0114-560X, Chen, Zihao, Hartmann, Joshua, Sun, Qiang, Dewenter, Matthias, Nazir, Sumra, Paluvai, Harikrishnareddy, Hagenmüller, Marco, Haberkorn, Uwe, Schlicker, Lisa, Frias-Soler, Roberto Carlos, Tyedmers, Jens, Maack, Christoph, Schulze, Almut and Backs, Johannes ORCID: https://orcid.org/0000-0002-2322-2699
bioRxiv : 2025.10.16.682731. 16 October 2025

Isogenic monocytes improve the responsiveness of hiPSC cardiac spheroids to cardiac stressors.
Strässler, Elisabeth T. ORCID: https://orcid.org/0000-0002-5286-9686, Kessler, Elise L., van Vliet, Emile F., Chirico, Nino, Na, Ellen, Cai, Qingqing, van Mil, Alain, Schiattarella, Gabriele G. ORCID: https://orcid.org/0000-0002-7582-7171, Gerhardt, Holger ORCID: https://orcid.org/0000-0002-3030-0384, Kränkel, Nicolle, de Jager, Saskia C.A., Sluijter, Joost P.G. and Landmesser, Ulf ORCID: https://orcid.org/0000-0002-0214-3203
bioRxiv : 2025.10.16.682827. 16 October 2025

Somatic Hdac4-902fs mutations lead to loss of HDAC4 function through nonsensemediated mRNA degradation.
Paluvai, Harikrishnareddy, Pepin, Mark E. ORCID: https://orcid.org/0000-0003-0114-560X, Schreiter, Friederike, Saadatmand, Alireza, Hagenmueller, Marco and Backs, Johannes ORCID: https://orcid.org/0000-0002-2322-2699
bioRxiv : 2025.10.14.682279. 15 October 2025

Lineage origin and microenvironment shape neuroblastoma transcriptional state and plasticity.
Fresmann, Nora ORCID: https://orcid.org/0000-0002-9233-5101, Koeppke, Julia, Gauert, Anton ORCID: https://orcid.org/0000-0002-3013-5374, Senoussi, Anis ORCID: https://orcid.org/0000-0002-7066-8917, Olivares-Chauvet, Pedro ORCID: https://orcid.org/0009-0008-4684-255X, Schott, Marie ORCID: https://orcid.org/0009-0000-7393-2421, Hoefer, Lennart, Henssen, Anton G. ORCID: https://orcid.org/0000-0003-1534-778X, Rajewsky, Nikolaus ORCID: https://orcid.org/0000-0002-4785-4332, Spanjaard, Bastiaan ORCID: https://orcid.org/0000-0003-1309-8839, Hagemann, Anja I.H. ORCID: https://orcid.org/0000-0001-5491-4607 and Junker, Jan Philipp ORCID: https://orcid.org/0000-0002-2826-8290
bioRxiv : 2025.10.13.682025. 14 October 2025

Unravelling drug resistant proteotypes through phenotype-resolved proteomics of single-cell derived colonies.
Qin, Di ORCID: https://orcid.org/0000-0002-9730-4072, Das, Ridhima ORCID: https://orcid.org/0009-0007-0238-5935, Schallenberg, Simon ORCID: https://orcid.org/0000-0002-7897-7116, Riecken, Kristoffer ORCID: https://orcid.org/0000-0001-9050-6766, Tinhofer, Ingeborg ORCID: https://orcid.org/0000-0002-0512-549X and Coscia, Fabian ORCID: https://orcid.org/0000-0002-2244-5081
bioRxiv : 2025.10.11.681009v2. 14 October 2025

The lncRNA landscape of cardiac resident macrophages and identification of Schlafenlnc as a regulator of macrophage migratory function.
Dueck, A. ORCID: https://orcid.org/0000-0002-7956-6327, Althaus, L., Heise, K., Esfandyari, D., Baygün, S., Brandes, R.P., Gagneur, J. ORCID: https://orcid.org/0000-0002-8924-8365, Jaé, N., Knolle, P., Leisegang, M.S. ORCID: https://orcid.org/0000-0003-3692-7142, Maegdefessel, L., Meitinger, T. ORCID: https://orcid.org/0000-0002-8838-8403, Niessing, D., Petzold, N., Ramanujam, D., Sager, H., Schulz, C., Theodorakis, E., Uzonyi, A., Weinberger, T., Wittig, I., Bader, M. ORCID: https://orcid.org/0000-0003-4780-4164, Schmidt-Supprian, M. and Engelhardt, S.
bioRxiv : 2022.11.30.518576v3. 2 October 2025

Staufen2 modulates the temporal dynamics of human neurogenesis in vitro.
Ganesh, Akshay Jaya ORCID: https://orcid.org/0009-0005-7579-2924, Fernández-Moya, Sandra Maria ORCID: https://orcid.org/0000-0002-5894-4296, Gutiérrez-Franco, Ana, Ferreira, Natalie Chaves ORCID: https://orcid.org/0000-0002-0905-2670, Tur-Guasch, Rafael, Romero-Moya, Damia ORCID: https://orcid.org/0000-0001-9947-3577, Giorgetti, Alessandra ORCID: https://orcid.org/0000-0001-5803-3567, Mularoni, Loris ORCID: https://orcid.org/0000-0001-7053-7717, Piwecka, Monika ORCID: https://orcid.org/0000-0003-4104-6577, Rybak-Wolf, Agnieszka ORCID: https://orcid.org/0000-0002-1192-5290 and Plass, Mireya ORCID: https://orcid.org/0000-0002-9891-2723
bioRxiv : 2025.10.02.679988. 2 October 2025

A specialized cold sensing system in the naked mole-rat.
Wang, Lin ORCID: https://orcid.org/0000-0002-8395-6184, Gomez-Restrepo, Alejandro, Niqula, Amanda ORCID: https://orcid.org/0000-0003-3141-2967, Jouhanneau, Jean-Sebastien ORCID: https://orcid.org/0000-0001-8804-5198, Mendez-Aranda, Daniel ORCID: https://orcid.org/0000-0001-9668-941X, Luo, Wenhan ORCID: https://orcid.org/0000-0001-5202-8855, Poulet, James F.A. ORCID: https://orcid.org/0000-0003-0296-5415, de la Pena, Elvira ORCID: https://orcid.org/0000-0001-5961-5067, Viana, Felix, Bégay, Valérie ORCID: https://orcid.org/0000-0002-9002-4211 and Lewin, Gary R. ORCID: https://orcid.org/0000-0002-2890-6352
bioRxiv : 2025.09.25.678629. 25 September 2025

Refined enterotyping reveals dysbiosis in global fecal metagenomes.
Keller, Marisa Isabell ORCID: https://orcid.org/0000-0002-1485-415X, Nishijima, Suguru ORCID: https://orcid.org/0000-0002-8444-9272, Podlesny, Daniel ORCID: https://orcid.org/0000-0002-5685-0915, Kim, Chan Yeong ORCID: https://orcid.org/0000-0002-0868-9872, Robbani, Shahriyar Mahdi ORCID: https://orcid.org/0000-0003-0161-0559, Schudoma, Christian ORCID: https://orcid.org/0000-0003-1157-1354, Fullam, Anthony ORCID: https://orcid.org/0000-0002-0884-8124, Schiller, Jonas, Letunic, Ivica ORCID: https://orcid.org/0000-0003-3560-4288, Akanni, Wasiu ORCID: https://orcid.org/0000-0002-2075-2387, Orakov, Askarbek ORCID: https://orcid.org/0000-0001-6823-5269, Schmidt, Thomas Sebastian ORCID: https://orcid.org/0000-0001-8587-4177, Marotta, Federico ORCID: https://orcid.org/0000-0002-0174-3901, Telzerow, Anja, Hazenbrink, Diënty H.M. ORCID: https://orcid.org/0000-0003-0368-1764, Hercog, Rajna, Kandels, Stefanie, Schierwagen, Robert, Klein, Sabine, Brol, Maximilian Joseph, Gu, Wenyi, Uschner, Frank Erhard, Papp, Maria, Laleman, Wim, Shawcross, Debbie, Conraad, Minneke J., Jalan, Rajiv, Holtz Thorhauge, Katrine, Johansen, Stine, Thiele, Maja, Krag, Aleksander, Trebicka, Jonel, Kuhn, Michael ORCID: https://orcid.org/0000-0002-2841-872X, Van Rossum, Thea ORCID: https://orcid.org/0000-0002-3598-5001 and Bork, Peer ORCID: https://orcid.org/0000-0002-2627-833X
bioRxiv : 2024.08.13.607711v3. 23 September 2025

Memory dysfunction and psychiatric outcomes in anti-NMDA receptor encephalitis are linked to altered structural brain complexity.
Krohn, Stephan ORCID: https://orcid.org/0000-0003-0683-5386, Camma, Guido, Zhao, Wei ORCID: https://orcid.org/0009-0000-9615-9558, Romanello, Amy ORCID: https://orcid.org/0000-0003-1257-9593, Wurdack, Katharina ORCID: https://orcid.org/0000-0003-0952-5658, Boeken, Ole Jonas, Rekers, Sophia ORCID: https://orcid.org/0000-0002-6161-6621, Paul, Friedemann ORCID: https://orcid.org/0000-0002-6378-0070, Pruess, Harald ORCID: https://orcid.org/0000-0002-8283-7976, Madan, Christopher R ORCID: https://orcid.org/0000-0003-3228-6501 and Finke, Carsten ORCID: https://orcid.org/0000-0002-7665-1171
bioRxiv : 2025.09.22.677264. 22 September 2025

Aberrant inheritance of extrachromosomal DNA amplifications promotes cancer evolution.
Marom, Shir, Lifshits Dayan, Inbar, Narasimha Kadali, Venkata, Giurgiu-Kraljič, Mădălina ORCID: https://orcid.org/0000-0001-5007-7442, Koifman, Gabriela ORCID: https://orcid.org/0000-0002-7728-5214, Hakeny, Karen, Chaurasia, Madhuri, Benamozig, Orlena, Nevo, Reinat ORCID: https://orcid.org/0009-0000-3327-4022, Azuri, Ido ORCID: https://orcid.org/0000-0002-2891-1514, Ryvkin, Julia ORCID: https://orcid.org/0000-0002-1172-8350, Rotkopf, Ron ORCID: https://orcid.org/0000-0001-9503-7348, Stelzer, Gil ORCID: https://orcid.org/0000-0001-9368-4912, Oniashvili, Nino, Mardoukh, Jacques, Pollock, Sarah, Iremadze, Nika, Shipony, Zohar ORCID: https://orcid.org/0000-0003-2110-8822, Kupervaser, Meital ORCID: https://orcid.org/0000-0002-1068-937X, Wigoda, Noa ORCID: https://orcid.org/0000-0002-4496-881X, Leshkowitz, Dena ORCID: https://orcid.org/0000-0002-4703-2830, Elazar, Zvulun ORCID: https://orcid.org/0000-0002-3231-4464, Berko, Esther ORCID: https://orcid.org/0000-0001-7181-1378, Henssen, Anton G. ORCID: https://orcid.org/0000-0003-1534-778X and Shoshani, Ofer ORCID: https://orcid.org/0000-0001-8918-9935
bioRxiv : 2025.09.19.677276. 21 September 2025

Cryo-mtscATAC-seq for single-cell mitochondrial DNA genotyping and clonal tracing in archived human tissues.
Salla, Maren ORCID: https://orcid.org/0009-0003-8453-2935, Obermayer, Benedikt ORCID: https://orcid.org/0000-0002-9116-630X, Cotta, Marie ORCID: https://orcid.org/0000-0002-2589-3189, Friebel, Ekaterina ORCID: https://orcid.org/0000-0003-1419-2376, Campo-Garcia, Juliana, Charalambous, Georgia, Bueno, Roemel Jeusep, Lieu, Dustin, Dabek, Patryk, Helmuth, Ashley, Tellides, George, Assi, Roland, Bankov, Katrin, Lodrini, Marco, Deubzer, Hedwig ORCID: https://orcid.org/0000-0002-6115-4893, Beule, Dieter ORCID: https://orcid.org/0000-0002-3284-0632, Chung, Hattie ORCID: https://orcid.org/0000-0001-8417-5606, Radbruch, Helena ORCID: https://orcid.org/0000-0001-6941-3397, Capper, David, Heppner, Frank ORCID: https://orcid.org/0000-0001-9816-8917, Starossom, Sarah C. ORCID: https://orcid.org/0000-0001-7935-9910, Lareau, Caleb A. ORCID: https://orcid.org/0000-0003-4179-4807, Liu, Ilon ORCID: https://orcid.org/0000-0002-6186-3630 and Ludwig, Leif S. ORCID: https://orcid.org/0000-0002-2916-2164
bioRxiv : 2025.09.17.675534. 20 September 2025

Capturing global pet dog gut microbial diversity and hundreds of near-finished bacterial genomes by using long-read metagenomics in a Shanghai cohort.
Cusco, Anna ORCID: https://orcid.org/0000-0002-9574-5755, Duan, Yiqian ORCID: https://orcid.org/0000-0002-8046-9831, Gil, Fernando, Chklovski, Alexei, Kruthi, Nithya ORCID: https://orcid.org/0000-0002-4149-0400, Pan, Shaojun, Forslund, Sofia ORCID: https://orcid.org/0000-0003-4285-6993, Lau, Susanne ORCID: https://orcid.org/0000-0002-5189-4265, Löber, Ulrike ORCID: https://orcid.org/0000-0001-7468-9531, Zhao, Xinmging and Coelho, Luis Pedro ORCID: https://orcid.org/0000-0002-9280-7885
bioRxiv : 2025.09.17.676595. 17 September 2025

Exovelo: cell states velocity estimation without parameter fitting.
Kolb, Yiftach Josef ORCID: https://orcid.org/0009-0002-3752-3326 and Haghverdi, Laleh ORCID: https://orcid.org/0000-0001-9280-9170
bioRxiv : 2025.07.02.662720v2. 12 September 2025

Contextualizing models: deriving a kinetic model of cancer metabolism including growth via stoichiometric reduction.
Komkova, Daria, Simon, Mareike ORCID: https://orcid.org/0000-0001-7213-9499, Wolf, Jana ORCID: https://orcid.org/0000-0003-3254-5868 and Steuer, Ralf ORCID: https://orcid.org/0000-0003-2217-1655
bioRxiv : 2025.08.29.672875. 3 September 2025

Slice-PASEF: maximising ion utilisation in LC-MS proteomics.
Sinn, Ludwig R. ORCID: https://orcid.org/0000-0003-4692-0681, Szyrwiel, Lukasz ORCID: https://orcid.org/0000-0003-1983-2950, Grossmann, Justus, Lau, Kate, Faisst, Katharina, Qin, Di ORCID: https://orcid.org/0000-0002-9730-4072, Mutschler, Florian ORCID: https://orcid.org/0009-0002-0992-7171, Khoury, Luke ORCID: https://orcid.org/0000-0001-7794-6812, Leduc, Andrew ORCID: https://orcid.org/0000-0001-6234-0623, Ralser, Markus ORCID: https://orcid.org/0000-0001-9535-7413, Coscia, Fabian ORCID: https://orcid.org/0000-0002-2244-5081, Selbach, Matthias ORCID: https://orcid.org/0000-0003-2454-8751, Slavov, Nikolai ORCID: https://orcid.org/0000-0003-2035-1820, Nagaraj, Nagarjuna, Steger, Martin ORCID: https://orcid.org/0000-0003-1637-8190 and Demichev, Vadim ORCID: https://orcid.org/0000-0002-2424-9412
bioRxiv : 2022.10.31.514544v3. 2 September 2025

Cellular dynamics and epidermal specialization during Arabidopsis floral development at single-cell resolution.
Chen, Siye ORCID: https://orcid.org/0009-0001-3521-5955, Neumann, Manuel ORCID: https://orcid.org/0000-0002-7883-0843, He, Zhaohui ORCID: https://orcid.org/0000-0002-8976-9494, Carew, Frederic ORCID: https://orcid.org/0009-0003-8387-7149, Smaczniak, Cezary ORCID: https://orcid.org/0000-0002-4663-8275, Braeuning, Caroline ORCID: https://orcid.org/0009-0007-1439-9920, Richter, Sarah, Zhang, Yingjue ORCID: https://orcid.org/0009-0001-7787-131X, Zhou, Xinkai ORCID: https://orcid.org/0000-0001-8791-294X and Kaufmann, Kerstin ORCID: https://orcid.org/0000-0001-7960-6256
bioRxiv : 2025.09.01.672611. 1 September 2025

Developmental changes in the carotid body transcriptome accompanying the maturation of chemosensitivity.
Hodson, Emma J. ORCID: https://orcid.org/0000-0003-3646-9348, Sugimoto, Yoichiro ORCID: https://orcid.org/0000-0003-1646-7679, Manamperige, Rahul S., Ford, Sage G., Botting-Lawford, Kimberley J., Niu, Youguo, Nathan, James A. ORCID: https://orcid.org/0000-0002-0248-1632, Giussani, Dino A. and Ratcliffe, Peter J.
bioRxiv : 2025.08.21.671502. 25 August 2025

GeneSys: generative modeling of developmental system.
Hsu, Che-Wei ORCID: https://orcid.org/0000-0003-3709-9748, Chen, Chia-Yu ORCID: https://orcid.org/0000-0003-1765-7132, Nolan, Trevor M. ORCID: https://orcid.org/0000-0003-1362-2557, Benfey, Philip N. ORCID: https://orcid.org/0000-0001-5302-758X and Ohler, Uwe ORCID: https://orcid.org/0000-0002-0881-3116
bioRxiv : 2025.08.20.671385. 25 August 2025

Detergent-free reconstitution of transmembrane proteins in giant liposomes of complex curvature by the Synthetic Membrane Transfer.
Meena, Hemraj, Zdanowicz, Rafal ORCID: https://orcid.org/0009-0005-5694-2704, Bock-Bierbaum, Tobias ORCID: https://orcid.org/0000-0003-0843-2716, Stephan, Till ORCID: https://orcid.org/0000-0002-4032-7644, Ottsen Knudsen, Sofie Dorothea, Jakobs, Stefan ORCID: https://orcid.org/0000-0002-8028-3121, Daumke, Oliver ORCID: https://orcid.org/0000-0002-6190-1414, Pedersen, Per A. and De Franceschi, Nicola ORCID: https://orcid.org/0000-0002-7221-613X
bioRxiv : 2025.08.23.671895. 23 August 2025

The establishment of cell-type specific gene regulation in the sea urchin embryo.
Brandenburg, Jonas Maurice, Trinks, Alexandra ORCID: https://orcid.org/0000-0001-9983-1506, Voijtasova, Dominika ORCID: https://orcid.org/0009-0007-4557-2490, Monaco, Anna Alessandra ORCID: https://orcid.org/0009-0000-5779-3505, Chang, William, Arsie, Roberto ORCID: https://orcid.org/0000-0002-7869-7624, Hu, Marian, Hamdoun, Amro ORCID: https://orcid.org/0000-0003-2568-048X, Jenniches, Chloe, Landthaler, Markus ORCID: https://orcid.org/0000-0002-1075-8734, Blüthgen, Nils ORCID: https://orcid.org/0000-0002-0171-7447 and Garfield, David Aaron ORCID: https://orcid.org/0000-0002-8790-797X
bioRxiv : 2025.08.12.669999. 13 August 2025

Specialised super-enhancer networks in stem cells and neurons.
Harabula, Izabela ORCID: https://orcid.org/0000-0002-9094-0519, Speakman, Liam ORCID: https://orcid.org/0009-0003-8950-6146, Musella, Francesco ORCID: https://orcid.org/0000-0002-2174-5840, Forillo, Luca ORCID: https://orcid.org/0000-0003-2967-0123, Zea-Redondo, Luna ORCID: https://orcid.org/0000-0001-9064-9126, Kukalev, Alexander ORCID: https://orcid.org/0000-0001-5847-3773, Beagrie, Robert A. ORCID: https://orcid.org/0000-0003-1076-5595, Morris, Kelly J., Fernandes, Lucas ORCID: https://orcid.org/0009-0004-6471-8713, Irastorza-Azcarate, Ibai ORCID: https://orcid.org/0000-0001-5245-2322, Fernandes, Ana M., Carvalho, Silvia ORCID: https://orcid.org/0000-0001-6436-205X, Szabó, Dominik ORCID: https://orcid.org/0000-0001-8109-5088, Ferrai, Carmelo ORCID: https://orcid.org/0000-0002-8088-2757, Nicodemi, Mario ORCID: https://orcid.org/0000-0002-8416-6416, Welch, Lonnie ORCID: https://orcid.org/0000-0001-6419-9416 and Pombo, Ana ORCID: https://orcid.org/0000-0002-7493-6288
bioRxiv : 2025.08.13.670083. 13 August 2025

Non-autonomous Vnd acts with autonomous Appl during mushroom body axon growth in Drosophila.
Marquilly, Claire, Boulanger, Ana, Busto, Germain U., Zinzen, Robert P. ORCID: https://orcid.org/0000-0002-8638-5102, Hassan, Bassem A., Fradkin, Lee G. and Dura, Jean-Maurice
bioRxiv : 2023.09.01.555727v2. 31 July 2025

TGFb-induced SMAD1/5 activation drives transient epithelial-to-mesenchymal transition in trophoblasts.
Mähr, Sophia, Ingolfsdottir, Hallfridur, Alexdottir, Marta Sorokina, Hartmann, Sunhild ORCID: https://orcid.org/0009-0001-0269-0565, Nonn, Olivia ORCID: https://orcid.org/0000-0001-6385-2866, Gunnarsdottir, Johanna, Steingrimsdottir, Þóra, Jatzlau, Jerome ORCID: https://orcid.org/0000-0002-1757-0267, Knaus, Petra ORCID: https://orcid.org/0000-0003-2492-1667 and Valdimarsdottir, Gudrun
bioRxiv : 2025.07.21.665880. 25 July 2025

Spatiotemporal dynamics of tumor microenvironment remodeling.
Lisek, Kamil ORCID: https://orcid.org/0000-0002-2406-8830, Theurillat, Ilan ORCID: https://orcid.org/0000-0002-1125-1951, Pentimalli, Tancredi Massimo ORCID: https://orcid.org/0000-0002-8461-7918, Beier, Svea ORCID: https://orcid.org/0009-0006-6473-8487, León-Periñán, Daniel ORCID: https://orcid.org/0000-0002-7970-0362, Antonatou, Anna, Dubnov, Serafima, Müller, Marion, Hubl, Florian, Xhuri, Artemis, Romanowicz, Hanna, Smolarz, Beata, Montaudon, Elodie, Raimundo, Sandra ORCID: https://orcid.org/0009-0000-3353-5456, Margineanu, Anca ORCID: https://orcid.org/0000-0002-6634-9729, Schott, Marie ORCID: https://orcid.org/0009-0000-7393-2421, Kunz, Séverine ORCID: https://orcid.org/0000-0002-0131-3506, Marangoni, Elisabetta, Karaiskos, Nikos ORCID: https://orcid.org/0000-0001-7771-3947, Nitzan, Mor, Birchmeier, Walter ORCID: https://orcid.org/0000-0003-1173-0829 and Rajewsky, Nikolaus ORCID: https://orcid.org/0000-0002-4785-4332
bioRxiv : 2025.07.15.662972. 18 July 2025

Spatiotemporal dynamics of tumor microenvironment remodeling.
Lisek, Kamil ORCID: https://orcid.org/0000-0002-2406-8830, Theurillat, Ilan ORCID: https://orcid.org/0000-0002-1125-1951, Pentimalli, Tancredi Massimo ORCID: https://orcid.org/0000-0002-8461-7918, Beier, Svea ORCID: https://orcid.org/0009-0006-6473-8487, León-Periñán, Daniel ORCID: https://orcid.org/0000-0002-7970-0362, Antonatou, Anna, Dubnov, Serafima, Müller, Marion, Hubl, Florian, Xhuri, Artemis, Romanowicz, Hanna, Smolarz, Beata, Montaudon, Elodie, Raimundo, Sandra ORCID: https://orcid.org/0009-0000-3353-5456, Margineanu, Anca ORCID: https://orcid.org/0000-0002-6634-9729, Schott, Marie ORCID: https://orcid.org/0009-0000-7393-2421, Kunz, Séverine ORCID: https://orcid.org/0000-0002-0131-3506, Marangoni, Elisabetta, Karaiskos, Nikos ORCID: https://orcid.org/0000-0001-7771-3947, Nitzan, Mor, Birchmeier, Walter ORCID: https://orcid.org/0000-0003-1173-0829 and Rajewsky, Nikolaus ORCID: https://orcid.org/0000-0002-4785-4332
bioRxiv : 2025.07.15.662972. 18 July 2025

Maternal smoking in early pregnancy disrupts placental function through syncytiotrophoblast and macrophage dysregulation.
Valdes, Daniela S. ORCID: https://orcid.org/0000-0002-1309-5147, Nimo, Jose ORCID: https://orcid.org/0000-0002-1565-7799, Nonn, Olivia ORCID: https://orcid.org/0000-0001-6385-2866, Ulrich, Juliane, Forstner, Désirée ORCID: https://orcid.org/0000-0001-5451-7580, Haider, Sandra ORCID: https://orcid.org/0000-0003-2409-1317, Ressler, Miriam ORCID: https://orcid.org/0000-0002-8669-9451, Pignitter, Marc ORCID: https://orcid.org/0000-0002-5793-8572, Müller, Dominik N. ORCID: https://orcid.org/0000-0003-3650-5644, Dechend, Ralf ORCID: https://orcid.org/0000-0001-6636-3080, Gauster, Martin ORCID: https://orcid.org/0000-0003-0386-6857, Coscia, Fabian ORCID: https://orcid.org/0000-0002-2244-5081 and Herse, Florian ORCID: https://orcid.org/0000-0002-9305-8134
bioRxiv : 2025.07.10.664172. 15 July 2025

DNA virus infections shape transposable elements activity in vitro and in vivo.
Tan, J., Franke, V. ORCID: https://orcid.org/0000-0003-3606-6792, Neugebauer, E., Pennisi, S., Schächtle, M.A., Lagisquet, J., Kuderna, A.K., Walter, S., Welker, I., Ensser, A., Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Stamminger, T., Gramberg, T., Akalin, A. ORCID: https://orcid.org/0000-0002-0468-0117, Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806 and Full, F.
bioRxiv : 2024.04.18.589901v2. 30 June 2025

Integrative structural interactomics reveals protein organization and structure in a giant virus.
Mühlberg, L. ORCID: https://orcid.org/0009-0008-8046-007X, Ruta, J. ORCID: https://orcid.org/0009-0007-0524-6885, Mikirtumov, V. ORCID: https://orcid.org/0009-0004-6849-4825, Burton-Smith, R. ORCID: https://orcid.org/0000-0002-1535-6419, Murata, K. ORCID: https://orcid.org/0000-0001-9446-3652, Kudryashev, M. ORCID: https://orcid.org/0000-0003-3550-6274, Okamoto, K. ORCID: https://orcid.org/0000-0002-4858-1196, Bogdanow, B. ORCID: https://orcid.org/0000-0002-9634-7353 and Liu, F. ORCID: https://orcid.org/0000-0002-2358-549X
bioRxiv : 2025.06.16.659922. 18 June 2025

High-throughput single-cell CRISPRi screens stratify neurodevelopmental functions of schizophrenia-associated genes.
Yildiz, U. ORCID: https://orcid.org/0000-0002-7175-362X, Claringbould, A. ORCID: https://orcid.org/0000-0002-9201-6557, Marttinen, M. ORCID: https://orcid.org/0000-0001-5861-4601, Campos-Fornés, V. ORCID: https://orcid.org/0000-0001-9992-1106, Lamprousi, M. ORCID: https://orcid.org/0000-0002-9149-9972, Saraswat, M. ORCID: https://orcid.org/0000-0002-1472-8049, Saver, M., Bunina, D. ORCID: https://orcid.org/0000-0002-5885-7440, Dorrity, M.W. ORCID: https://orcid.org/0000-0002-7691-6504, Zaugg, J. ORCID: https://orcid.org/0000-0001-8324-4040 and Noh, K.M. ORCID: https://orcid.org/0000-0002-0708-787X
bioRxiv : 2025.06.13.659629. 16 June 2025

Structures of EHD2 filaments on curved membranes provide a model for caveolar neck stabilization.
Vázquez-Sarandeses, E., Mikirtumov, V. ORCID: https://orcid.org/0009-0004-6849-4825, Noel, J.K. ORCID: https://orcid.org/0000-0003-3168-6036, Kudryashev, M. ORCID: https://orcid.org/0000-0003-3550-6274 and Daumke, O. ORCID: https://orcid.org/0000-0002-6190-1414
bioRxiv : 2025.06.05.658037. 7 June 2025

Erlotinib induces 3D genome rearrangements in lung cancer cells activating tumor suppressor genes through FOXA2-bound Epromoters.
Swaminathan, Guruprasadh ORCID: https://orcid.org/0009-0005-4727-2032, Cordero, Julio, Günther, Stefan, Graumann, Johannes ORCID: https://orcid.org/0000-0002-3015-5850, Braun, Thomas ORCID: https://orcid.org/0000-0002-6165-4804, Dobreva, Gergana ORCID: https://orcid.org/0000-0002-4814-9416 and Barreto, Guillermo ORCID: https://orcid.org/0000-0002-7777-4712
bioRxiv : 2025.05.13.653883. 14 May 2025

Reconfiguration of genome-lamina interactions marks the commissioning of limb cell-fates.
Chudzik, K. ORCID: https://orcid.org/0000-0002-7606-8381, Guerreiro, I. ORCID: https://orcid.org/0000-0003-1390-3535, Kefalopoulou, S. ORCID: https://orcid.org/0000-0002-7565-9614, Abraham, A. ORCID: https://orcid.org/0000-0003-3533-6543, Schindler, M. ORCID: https://orcid.org/0000-0003-3363-1864, Ringel, A. ORCID: https://orcid.org/0000-0002-6392-6076, Nicodemi, M. ORCID: https://orcid.org/0000-0002-8416-6416, Solovei, I. ORCID: https://orcid.org/0000-0002-6813-7279, Chiariello, A.M. ORCID: https://orcid.org/0000-0002-6112-0167, Mundlos, S. ORCID: https://orcid.org/0000-0002-9788-3166, Kind, J. ORCID: https://orcid.org/0000-0001-7538-2638 and Robson, M.I. ORCID: https://orcid.org/0000-0003-1126-3538
bioRxiv : 2025.05.05.651267. 7 May 2025

UBE3C links ubiquitin signaling to epitranscriptomic control of cortical neurogenesis.
Borisova, Ekaterina, Cuthill, Katherine J. ORCID: https://orcid.org/0000-0003-3328-3249, Dannenberg, Rike, Koch, Janina, Nowaczyk, Julius ORCID: https://orcid.org/0009-0009-7068-4958, Schaub, Theres, Schwark, Manuela ORCID: https://orcid.org/0009-0008-1711-457X, Kastelic, N., Kupryianchyk-Schultz, I. ORCID: https://orcid.org/0009-0007-6442-4469, Kirchner, M. ORCID: https://orcid.org/0000-0002-7049-534X, Pentimalli, T.M. ORCID: https://orcid.org/0000-0002-8461-7918, Fokkens, T.J. ORCID: https://orcid.org/0009-0005-4689-4024, Stein, F., Dietrich, C., Quedenau, C. ORCID: https://orcid.org/0000-0002-6846-4915, Borodina, T. ORCID: https://orcid.org/0000-0002-6978-016X, Schwefel, D. ORCID: https://orcid.org/0000-0002-2945-0908, Conrad, T. ORCID: https://orcid.org/0000-0001-5618-6295, Rybak-Wolf, A. ORCID: https://orcid.org/0000-0002-1192-5290, Rajewsky, N. ORCID: https://orcid.org/0000-0002-4785-4332, Mertins, P. ORCID: https://orcid.org/0000-0002-2245-528X, Haberkant, P. ORCID: https://orcid.org/0000-0002-5608-9062, Lorenz, S. ORCID: https://orcid.org/0000-0002-9639-2381, Brose, N. ORCID: https://orcid.org/0000-0003-0938-8534, Kawabe, H. ORCID: https://orcid.org/0000-0001-5650-8696, Tarabykin, V. ORCID: https://orcid.org/0000-0001-8931-7263 and Ambrozkiewicz, M.C. ORCID: https://orcid.org/0000-0001-5225-5230
bioRxiv : 2025.04.09.646620v2. 29 April 2025

Familial Alzheimer disease mutation identifies novel role of SORLA in release of neurotrophic exosomes.
Juul-Madsen, K. ORCID: https://orcid.org/0000-0002-5309-5221, Rudolph, I.M. ORCID: https://orcid.org/0000-0002-3903-0755, Gomes, J.P., Meyer, K. ORCID: https://orcid.org/0000-0002-8244-6887, Ovesen, P.L. ORCID: https://orcid.org/0000-0001-8801-4711, Gorniak-Walas, M. ORCID: https://orcid.org/0000-0003-1236-8622, Kokoli, M. ORCID: https://orcid.org/0000-0002-1411-3730, Telugu, N.S. ORCID: https://orcid.org/0000-0003-4509-7056, Sivertsen, M.V.T., Sutherland, D., Palmfeldt, J.S, Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Andersen, O. ORCID: https://orcid.org/0000-0003-4226-3354, Selbach, M. ORCID: https://orcid.org/0000-0003-2454-8751 and Willnow, T.E. ORCID: https://orcid.org/0000-0001-9515-7921
bioRxiv : 2025.04.22.649924. 25 April 2025

An integrated landscape of mRNA and protein isoforms.
Kedan, A., Zauber, H. ORCID: https://orcid.org/0000-0003-2595-1147, Wang, M.R., Zhu, Q., Fang, L. ORCID: https://orcid.org/0000-0003-4502-1756, Chen, W. ORCID: https://orcid.org/0000-0003-3263-1627 and Selbach, M. ORCID: https://orcid.org/0000-0003-2454-8751
bioRxiv : 2025.04.16.648713. 19 April 2025

Ab-trapping - a peripheral staining artifact in antibody-based microscopy and genomics.
Chudzik, K. ORCID: https://orcid.org/0000-0002-7606-8381, Sato, Y. ORCID: https://orcid.org/0000-0002-7805-9171, Yan, X. ORCID: https://orcid.org/0000-0003-3525-0942, Ullrich, S. ORCID: https://orcid.org/0000-0002-1765-1251, Trakarnphornsombat, W. ORCID: https://orcid.org/0000-0002-3287-746X, Schermelleh, L. ORCID: https://orcid.org/0000-0002-1612-9699, Fudenberg, G. ORCID: https://orcid.org/0000-0001-5905-6517, Kimura, H. ORCID: https://orcid.org/0000-0003-0854-083X, Robson, M.I. ORCID: https://orcid.org/0000-0003-1126-3538 and Solovei, I. ORCID: https://orcid.org/0000-0002-6813-7279
bioRxiv : 2025.04.09.648027. 10 April 2025

Profilin promotes lamellipodium protrusion by tuning the antagonistic activities of CP and VASP.
Tang, Y., Schaks, M., Mietkowska, M., Scholz, J., Benavente-Naranjo, R., Korber, S., Li, Z., Lambert, C. ORCID: https://orcid.org/0000-0002-1899-8214, Stradal, T.E.B. ORCID: https://orcid.org/0000-0002-0352-9474, Karlsson, R., Bieling, P. ORCID: https://orcid.org/0000-0002-7458-4358, Faix, J., Falcke, M. ORCID: https://orcid.org/0000-0001-7137-1114 and Rottner, K. ORCID: https://orcid.org/0000-0003-4244-4198
bioRxiv : 2025.03.26.645585. 27 March 2025

LINC01503-MP is a mitochondrial microprotein that promotes cell proliferation and oxidative metabolism.
Dewani, N. ORCID: https://orcid.org/0000-0002-2287-6674, Ruiz-Orera, J. ORCID: https://orcid.org/0000-0002-8317-0034, Popp, O. ORCID: https://orcid.org/0000-0001-6240-4666, Liang, N. ORCID: https://orcid.org/0009-0008-8137-6873, Sugarawa, M. ORCID: https://orcid.org/0000-0001-7146-533X, Schulz, J.F. ORCID: https://orcid.org/0000-0002-8157-2224, Witte, F., Sandmann, C. ORCID: https://orcid.org/0000-0002-3847-0708, Tsuji, T. ORCID: https://orcid.org/0000-0001-9810-7305, Blachut, S. ORCID: https://orcid.org/0009-0007-0102-9867, Katagiri, T., Kondova, I., Owada, S., Yoshii, S., Kataoka, H. ORCID: https://orcid.org/0000-0002-2502-8304, Kurtz, A. ORCID: https://orcid.org/0000-0003-3301-6546, Nakase, H. ORCID: https://orcid.org/0000-0003-2848-6586, van Heesch, S. ORCID: https://orcid.org/0000-0001-9593-1980, Mertins, P. ORCID: https://orcid.org/0000-0002-2245-528X, Hübner, N. ORCID: https://orcid.org/0000-0002-1218-6223 and Kanda (Hübner), M. ORCID: https://orcid.org/0000-0003-3468-3586
bioRxiv : 2025.03.19.644091. 19 March 2025

3D epigenome evolution underlies divergent gene regulatory programs in primate neural development.
Vangelisti, S., Chong, F., Dietl, T., Zywitza, V. ORCID: https://orcid.org/0000-0003-3055-8569, Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Enard, W. and Bonev, B.
bioRxiv : 2025.03.11.642620. 12 March 2025

Bimodal nonlinear dendrites in PV+ basket cells drive distinct memory-related oscillations.
Tzilivaki, A. ORCID: https://orcid.org/0000-0003-0140-2864, Larkum, M.E. and Schmitz, D. ORCID: https://orcid.org/0000-0003-2741-5241
bioRxiv : 2024.09.11.612262v3. 21 February 2025

Dissecting the role of RNA-binding proteins in early herpes simplex virus 1 transcription using acute protein depletion.
Barke, N ORCID: https://orcid.org/0009-0004-5862-6628, Masser, S., Stalling, D., Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Zinzen, R.P. ORCID: https://orcid.org/0000-0002-8638-5102, Schreiner, S., Bosse, J. and Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734
bioRxiv : 2025.02.10.637450. 11 February 2025

Formation of amyloid-like HTTex1 aggregates in neurons, downregulation of synaptic proteins and early mortality of Huntington's disease flies are causally linked.
Ast, A. ORCID: https://orcid.org/0000-0002-2312-1257, Roth, L., Brusendorf, L., Schindler, F. ORCID: https://orcid.org/0000-0002-3320-8284, Ammar, O.W.M. ORCID: https://orcid.org/0009-0003-5341-4434, Berberich, S., Edel, J., Bonsor, M., Georgii, E., Hänig, C. ORCID: https://orcid.org/0000-0003-1973-7646, Langnick, C., Ivanov, A. ORCID: https://orcid.org/0000-0002-4824-1925, Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Piraud, M., Kunz, S. ORCID: https://orcid.org/0000-0002-0131-3506, Popp, O. ORCID: https://orcid.org/0000-0001-6240-4666, Mertins, P. ORCID: https://orcid.org/0000-0002-2245-528X, Petzoldt, A.G. and Wanker, E.E. ORCID: https://orcid.org/0000-0001-8072-1630
bioRxiv : 2025.02.06.636778. 7 February 2025

Esophageal adenocarcinoma relapse after chemoradiation is dominated by a basal-like subtype.
Hoppe, S., Noseir, S., Yazbeck, A., Zaburannyi, N., Grossbach, J., Lyu, S.I., Velazquez Camacho, O., Müller, S., Gebauer, F., Richartz, V., Holz, B., Berg, J., Achter, V., Altmüller, J. ORCID: https://orcid.org/0000-0003-4372-1521, Becker, K., Arolt, C., Meder, L., Zhao, Y., Schlößer, H., Baus, W.W., Kamp, F., Baues, C., Beyer, A. ORCID: https://orcid.org/0000-0002-3891-2123, Odenthal, M., Quaas, A., Buettner, R. and Hillmer, A.M. ORCID: https://orcid.org/0000-0002-3381-7266
bioRxiv : 2025.01.28.635332. 1 February 2025

Transcriptional dosage of oncogenic KRAS drives lung adenocarcinoma cell states, progression and metastasis.
Serresi, M. ORCID: https://orcid.org/0000-0001-6839-8658, Cetin, A.O. ORCID: https://orcid.org/0000-0001-9142-253X, Dramaretska, Y. ORCID: https://orcid.org/0000-0002-9792-0465, Kertalli, S., Schmitt, M.J. ORCID: https://orcid.org/0000-0001-8296-5858, Naumann, H. ORCID: https://orcid.org/0000-0003-3883-0432, Zschummel, M. ORCID: https://orcid.org/0000-0002-4778-8742, Liesse-Labat, M. ORCID: https://orcid.org/0000-0001-7082-6076, Maciel, L.F. ORCID: https://orcid.org/0000-0003-2220-7072, Declercq, J. ORCID: https://orcid.org/0000-0002-1244-7729, Marine, J.C. ORCID: https://orcid.org/0000-0003-2433-9837 and Gargiulo, G. ORCID: https://orcid.org/0000-0001-5414-4251
bioRxiv : 2024.12.29.630643. 30 December 2024

Tissue-specific apparent mtDNA heteroplasmy and its relationship with ageing and mtDNA gene expression.
Wengert, S., Giannoulis, X., Kreitmaier, P., Kautz, P. ORCID: https://orcid.org/0000-0002-9658-1676, Ludwig, L.S. ORCID: https://orcid.org/0000-0002-2916-2164, Prokisch, H. ORCID: https://orcid.org/0000-0003-2379-6286, Casale, F.P. ORCID: https://orcid.org/0000-0002-5450-1981, Heinig, M. ORCID: https://orcid.org/0000-0002-5612-1720 and Cai, N. ORCID: https://orcid.org/0000-0001-7496-2075
bioRxiv : 2024.12.11.627989. 16 December 2024

Poxviruses induce a nuclear environment in the cytoplasm to promote viral replication.
Veratti, P., Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Read, C., Scherer, M., Tan, J., Walther, P., Wider, S., Weidl, D. and Full, F.
bioRxiv : 2024.11.21.624458. 22 November 2024

Cell-type specific prediction of RNA stability from RNA-protein interactions.
Saran, S. ORCID: https://orcid.org/0009-0001-0561-6328, Lebedeva, S. ORCID: https://orcid.org/0000-0003-0857-8256, Hirsekorn, A. and Ohler, U. ORCID: https://orcid.org/0000-0002-0881-3116
bioRxiv : 2024.11.19.624283. 19 November 2024

Interlaboratory comparison of standardised metabolomics and lipidomics analyses in human and rodent blood using the MxP® Quant 500 kit.
Zararsiz, G.E., Lintelmann, J., Cecil, A., Kirwan, J. ORCID: https://orcid.org/0000-0002-5423-1651, Poschet, G., Gegner, H.M., Schuchardt, S., Guan, X.L., Saigusa, D., Wishart, D., Zheng, J., Mandal, R., Adams, K., Thompson, J.W., Snyder, M.P., Contrepois, K., Chen, S., Ashrafi, N., Akyol, S., Yilmaz, A., Graham, S.F., O'Connell, T.M., Kalecký, K., Bottiglieri, T., Limonciel, A., Pham, H.T., Koal, T., Adamski, J. and Kastenmüller, G. ORCID: https://orcid.org/0000-0002-2368-7322
bioRxiv : 2024.11.13.619447. 14 November 2024

Targeted H3K9 acetylation at lncSox1 promoter by cell type-specific epigenome editing promotes intermediate progenitor proliferation in developing mouse cortex.
Sokpor, Godwin ORCID: https://orcid.org/0000-0002-7120-0793, Ulmke, P.A. ORCID: https://orcid.org/0000-0001-6960-9859, Nguyen, H.D., Pham, L., Kakani, P., Chu, V.T. ORCID: https://orcid.org/0000-0003-1327-8696, Arnold, S.J. ORCID: https://orcid.org/0000-0002-2688-9210, Brand-Saberi, B. ORCID: https://orcid.org/0000-0003-3309-9724, Nguyen, H.P. and Tuoc, T. ORCID: https://orcid.org/0000-0003-2079-7259
bioRxiv : 2024.11.05.621758. 5 November 2024

Artifacts in single-cell mitochondrial DNA mutation analyses misinform phylogenetic inference.
Lareau, C.A. ORCID: https://orcid.org/0000-0003-4179-4807, Chapman, M.S. ORCID: https://orcid.org/0000-0002-5320-8193, Penter, L. ORCID: https://orcid.org/0000-0002-9060-0207, Nawy, T. ORCID: https://orcid.org/0000-0003-3720-3699, Pe’er, D. ORCID: https://orcid.org/0000-0002-9259-8817 and Ludwig, L.S. ORCID: https://orcid.org/0000-0002-2916-2164
bioRxiv : 2024.07.28.605517v2. 5 October 2024

Sociality shapes mitochondrial adaptations supporting hypoxia tolerance.
Rossi, A. ORCID: https://orcid.org/0000-0002-8819-9813, Ruwolt, M. ORCID: https://orcid.org/0009-0000-7220-406X, Kakouri, P., Kosten, T., Kunz, S. ORCID: https://orcid.org/0000-0002-0131-3506, Puchkov, D. ORCID: https://orcid.org/0000-0001-8341-4847, Reznick, J. ORCID: https://orcid.org/0000-0001-7921-5466, Purfürst, B. ORCID: https://orcid.org/0000-0002-9887-7577, Omerbašić, D. ORCID: https://orcid.org/0000-0003-1839-4856, Méndez Aranda, D. ORCID: https://orcid.org/0000-0001-9668-941X, Carai, G., Mastrobuoni, G. ORCID: https://orcid.org/0000-0003-4509-1295, Hart, D.W. ORCID: https://orcid.org/0000-0002-4592-558X, Carraro, M. ORCID: https://orcid.org/0000-0002-4573-9306, Tommasin, L. ORCID: https://orcid.org/0000-0002-6029-0375, Bennett, N.C. ORCID: https://orcid.org/0000-0001-9748-2947, Bégay, V. ORCID: https://orcid.org/0000-0002-9002-4211, Faelber, K., Daumke, O. ORCID: https://orcid.org/0000-0002-6190-1414, Bernardi, P. ORCID: https://orcid.org/0000-0001-9187-3736, Park, T.J. ORCID: https://orcid.org/0000-0002-2447-2948, Kempa, S. ORCID: https://orcid.org/0000-0002-0696-9299, Liu, F. and Lewin, G.R. ORCID: https://orcid.org/0000-0002-2890-6352
bioRxiv : 2024.09.30.615914. 2 October 2024

YAP/TAZ signaling in allantois-derived cells is required for placental vascularization.
Gao, S., Thillaikumaran, T., Dominguez, M.H., Giang, W., Hayes, K. ORCID: https://orcid.org/0000-0002-4858-7846, Chen, X., Pace, J., Bockman, J., Jathan, D., Sung, D., Narayan, S., Frankfurter, M., Mericko-Ishizuka, P., Yang, J., Castro, M. ORCID: https://orcid.org/0000-0001-7851-7446, Potente, M. ORCID: https://orcid.org/0000-0002-5689-0036 and Kahn, M.L. ORCID: https://orcid.org/0000-0002-6489-7086
bioRxiv : 2024.09.15.613151. 16 September 2024

Pyjacker identifies enhancer hijacking events in acute myeloid leukemia including MNX1 activation via deletion 7q.
Sollier, E. ORCID: https://orcid.org/0000-0002-3612-8562, Riedel, A. ORCID: https://orcid.org/0000-0002-0626-3894, Toprak, U.H. ORCID: https://orcid.org/0009-0009-6923-6816, Wierzbinska, J.A., Weichenhan, D. ORCID: https://orcid.org/0000-0002-7915-412X, Schmid, J.P. ORCID: https://orcid.org/0009-0001-3869-8868, Hakobyan, M. ORCID: https://orcid.org/0000-0003-4719-5186, Touzart, A. ORCID: https://orcid.org/0000-0002-8888-2292, Jahn, E. ORCID: https://orcid.org/0009-0001-0741-1166, Vick, B. ORCID: https://orcid.org/0000-0003-1956-2778, Brown-Burke, F. ORCID: https://orcid.org/0000-0001-6692-8678, Kelly, K., Kelekci, S. ORCID: https://orcid.org/0000-0002-4896-0110, Pejkovska, A. ORCID: https://orcid.org/0000-0002-8727-544X, Goyal, A. ORCID: https://orcid.org/0000-0002-9830-3987, Baehr, M., Breuer, K. ORCID: https://orcid.org/0000-0003-3716-7739, Chen, M.J.M. ORCID: https://orcid.org/0000-0002-8721-0304, Llamazares-Prada, M. ORCID: https://orcid.org/0000-0001-6559-9374, Hartmann, M. ORCID: https://orcid.org/0000-0002-4072-4658, Schoenung, M. ORCID: https://orcid.org/0000-0002-9778-9698, Correia, N., Trumpp, A. ORCID: https://orcid.org/0000-0002-6212-3466, Abdullah, Y. ORCID: https://orcid.org/0000-0002-5694-0910, Klingmueller, U. ORCID: https://orcid.org/0000-0001-9845-3099, Mughal, S.S. ORCID: https://orcid.org/0000-0003-3468-8467, Brors, B. ORCID: https://orcid.org/0000-0001-5940-3101, Westermann, F. ORCID: https://orcid.org/0000-0003-1584-3636, Schlesner, M. ORCID: https://orcid.org/0000-0002-5896-4086, Vosberg, S. ORCID: https://orcid.org/0000-0002-8464-1483, Herold, T. ORCID: https://orcid.org/0000-0002-9615-9432, Greif, P.A. ORCID: https://orcid.org/0000-0002-3744-7936, Pfeifer, D., Luebbert, M., Fischer, T., Heidel, F. ORCID: https://orcid.org/0000-0003-2438-1955, Gebhard, C. ORCID: https://orcid.org/0000-0002-5459-8381, Walter, W., Haferlach, T. ORCID: https://orcid.org/0000-0003-0196-2837, Eisfeld, A.K. ORCID: https://orcid.org/0000-0001-6442-1419, Mrozek, K., Nicolet, D. ORCID: https://orcid.org/0000-0001-7796-0251, Bullinger, L. ORCID: https://orcid.org/0000-0002-5890-5510, Smeenk, L. ORCID: https://orcid.org/0000-0001-7025-8515, Erpelinck, C. ORCID: https://orcid.org/0000-0002-3965-4488, Mulet-Lazaro, R. ORCID: https://orcid.org/0000-0003-0298-7948, Delwel, R. ORCID: https://orcid.org/0000-0001-6903-3271, Ernst, A. ORCID: https://orcid.org/0000-0002-8082-3677, Scherer, M. ORCID: https://orcid.org/0000-0001-7990-6179, Lutsik, P. ORCID: https://orcid.org/0000-0001-9383-8555, Jeremias, I. ORCID: https://orcid.org/0000-0003-1773-7677, Doehner, K. ORCID: https://orcid.org/0000-0002-2261-9862, Doehner, H. ORCID: https://orcid.org/0000-0003-2116-5536, Lipka, D.B. ORCID: https://orcid.org/0000-0001-5081-7869 and Plass, C. ORCID: https://orcid.org/0000-0003-2554-3952
bioRxiv : 2024.09.11.611224. 13 September 2024

IGF1R is protective in pneumococcal pneumonia.
Felten, M. ORCID: https://orcid.org/0000-0001-5808-5025, Teixeira Alves, L.G. ORCID: https://orcid.org/0000-0002-5822-4168, Letsiou, E., Arnedo, E.A., Piñeiro-Hermida, S., López, I.P., Dietert, K., Firsching, T., Gruber, A.D., Fatykhova, D., Hocke, A., Lingscheid, T., Lienau, J., Rohde, G., Pichel, J.G. and Witzenrath, M.
bioRxiv : 2024.09.11.612370. 11 September 2024

Renal proximal tubules are sensitive to metabolic acidosis.
Hennings, J.C. ORCID: https://orcid.org/0000-0002-0375-5682, Murthy, K.S., Picard, N., Cabrita, I., Böhm, D., Krause, M.E., Shah, V., Baraka-Vidot, J., Khundadze, M., Stauber, T. ORCID: https://orcid.org/0000-0003-0727-6109, Böckenhauer, D., Jentsch, T.J. ORCID: https://orcid.org/0000-0002-3509-2553, Bachmann, S., Schermer, B., Eladari, D., Chambrey, R. and Hübner, C.A.
bioRxiv : 10.1101/2024.08.19.608649. 19 August 2024

Ultraslow serotonin oscillations in the hippocampus delineate substates across NREM and waking.
Cooper, C., Parthier, D. ORCID: https://orcid.org/0000-0001-8775-024X, Sibille, J., Tukker, J.J. ORCID: https://orcid.org/0000-0002-4394-199X, Tritsch, N.X. ORCID: https://orcid.org/0000-0003-3181-7681 and Schmitz, D. ORCID: https://orcid.org/0000-0003-2741-5241
bioRxiv : 2024.07.09.602643. 13 July 2024

Reporter-based screening identifies RAS-RAF mutations as drivers of resistance to active-state RAS inhibition in colorectal cancer.
Aust, O., Blanc, E. ORCID: https://orcid.org/0000-0002-4369-0254, Lüthen, M. ORCID: https://orcid.org/0000-0001-5557-6419, Hollek, V. ORCID: https://orcid.org/0000-0001-9768-5568, Astaburuaga-García, R. ORCID: https://orcid.org/0000-0003-1179-4080, Klinger, B. ORCID: https://orcid.org/0000-0003-0242-1506, Trinks, A. ORCID: https://orcid.org/0000-0001-9983-1506, Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Papke, B. ORCID: https://orcid.org/0000-0001-8156-7508, Horst, D. ORCID: https://orcid.org/0000-0003-4755-5743, Blüthgen, N. ORCID: https://orcid.org/0000-0002-0171-7447, Sers, C. ORCID: https://orcid.org/0000-0002-6219-1514, Der, C.J. ORCID: https://orcid.org/0000-0002-7751-2747 and Morkel, M. ORCID: https://orcid.org/0000-0002-2553-9999
bioRxiv : 2024.07.01.601542v2. 12 July 2024

Polycystin-1 loss of function increases susceptibility to atrial fibrillation through impaired DNA damage response.
Hendrickson, T. ORCID: https://orcid.org/0000-0001-6773-4410, Giese, A., Fiedler, M., Perez, W., Reyes-Sanchez, E., Reyes-Lozano, M., Wang, S., Venegas-Zamora, L., Provasek, V. ORCID: https://orcid.org/0000-0002-5893-0230, El-Essawi, A., Breitenbach, I., Fakuade, F.E. ORCID: https://orcid.org/0000-0001-6683-6079, Kutschka, I., Schiattarella, G.G. ORCID: https://orcid.org/0000-0002-7582-7171, Voigt, N. ORCID: https://orcid.org/0000-0001-8230-2341, Valderrabano, M. ORCID: https://orcid.org/0000-0002-8401-1684 and Altamirano, F. ORCID: https://orcid.org/0000-0002-1612-2729
bioRxiv : 2024.07.08.602618. 12 July 2024

Deep learning-driven neuromorphogenesis screenings identify repurposable drugs for mitochondrial disease.
Menacho, C., Okawa, S., Alvarez-Merz, I., Wittich, A., Muñoz-Oreja, M., Lisowski, P. ORCID: https://orcid.org/0000-0002-3634-1072, Pentimalli, T.M. ORCID: https://orcid.org/0000-0002-8461-7918, Rybak-Wolf, A. ORCID: https://orcid.org/0000-0002-1192-5290, Inak, G., Zakin, S., Thevandavakkam, M., Petersilie, L., Zaliani, A., Mlody, B. ORCID: https://orcid.org/0000-0001-5184-1772, Seibt, A., Donnelly, J., Woleben, K., Fernandez-Checa, J., Herebian, D., Mayatepek, E., Rajewsky, N. ORCID: https://orcid.org/0000-0002-4785-4332, Spinazzola, A., Schuelke, M. ORCID: https://orcid.org/0000-0003-2824-3891, Perlstein, E. ORCID: https://orcid.org/0000-0002-4734-4391, Rossi, A., Distelmaier, F., Holt, I.J., Pless, O. ORCID: https://orcid.org/0000-0002-1468-316X, Rose, C., Del Sol, A. and Prigione, A. ORCID: https://orcid.org/0000-0001-9457-1952
bioRxiv : 2024.07.08.602501. 12 July 2024

Mechanical strain activates planar cell polarity signaling to coordinate vascular cell dynamics.
Golbach, L., Saha, T., Odenthal-Schnittler, M. ORCID: https://orcid.org/0000-0001-8467-7585, Lücking, J., Velic, A., Akmeric, E.B. ORCID: https://orcid.org/0000-0003-4463-8017, Bornhorst, D. ORCID: https://orcid.org/0000-0003-4084-0250, Popp, O. ORCID: https://orcid.org/0000-0001-6240-4666, Mertins, P. ORCID: https://orcid.org/0000-0002-2245-528X, Gunawan, F. ORCID: https://orcid.org/0000-0002-5592-9680, Gerhardt, H. ORCID: https://orcid.org/0000-0002-3030-0384, Macek, B. ORCID: https://orcid.org/0000-0002-1206-2458, Trappmann, B. ORCID: https://orcid.org/0000-0002-6260-4075, Schnittler, H.J. ORCID: https://orcid.org/0000-0001-6807-3343, Galic, M. ORCID: https://orcid.org/0000-0002-4493-2542 and Matis, M. ORCID: https://orcid.org/0000-0003-3972-1983
bioRxiv : 2024.06.25.600357. 26 June 2024

Single-cell variations of circadian clock and immune gene expression in microglia and neurodegeneration.
Ouk, K., Yalcin, M., Rigat, L., Keren-Shaul, H., David, E., Knop, A., Böttcher, C. ORCID: https://orcid.org/0000-0002-6226-586X, Kramer, A., Amit, I., Relógio, A. and Priller, J. ORCID: https://orcid.org/0000-0001-7596-0979
bioRxiv : 2024.06.16.599193. 16 June 2024

Perinatal brain group 3 innate lymphoid cells are involved in the formation of murine dural lymphatics.
del Rio Serrato, A. ORCID: https://orcid.org/0000-0002-3706-3449, Latorre Hernández, B., Bartl, E., Stehle, C., Hölsken, O., Diefenbach, A., Romagnani, C. and Infante-Duarte, C. ORCID: https://orcid.org/0000-0003-3005-351X
bioRxiv : 2024.06.12.597323. 14 June 2024

Liver-like glycogen metabolism supports glycolysis in naked mole-rat heart during ischaemia.
Bundgaard, A. ORCID: https://orcid.org/0000-0001-9716-8333, Wang, N., Vyshkvorkina, I. ORCID: https://orcid.org/0000-0002-3144-6086, Jacome Burbano, M.S. ORCID: https://orcid.org/0000-0001-8770-9378, Cherevatenko, M. ORCID: https://orcid.org/0009-0003-0938-1233, Georgomanolis, T. ORCID: https://orcid.org/0000-0002-4066-9257, Dethloff, F., Giavalisco, P. ORCID: https://orcid.org/0000-0002-4636-1827, Lackmann, J.W., Lewin, G.R. ORCID: https://orcid.org/0000-0002-2890-6352, Frezza, C. ORCID: https://orcid.org/0000-0002-3293-7397 and Reznick, J. ORCID: https://orcid.org/0000-0001-7921-5466
bioRxiv : 2024.06.09.598072. 9 June 2024

Targeting complement C3a receptor resolves mitochondrial hyperfusion and subretinal microglial activation in progranulin-deficient frontotemporal dementia.
Tan, L.X., Oertel, F.C. ORCID: https://orcid.org/0000-0003-4906-5983, Cheng, A., Cobigo, Y. ORCID: https://orcid.org/0000-0002-0354-4092, Keihani, A., Bennett, D.J., Abdelhak, A. ORCID: https://orcid.org/0000-0001-9731-4169, Montes, S.C. ORCID: https://orcid.org/0000-0003-1211-6046, Chapman, M., Chen, R.Y., Cordano, C., Ward, M.E. ORCID: https://orcid.org/0000-0002-5296-8051, Casaletto, K., Kramer, J.H., Rosen, H.J., Boxer, A., Miller, B.L., Green, A.J., Elahi, F.M. and Lakkaraju, A.
bioRxiv : 2024.05.29.595206. 1 June 2024