2025
Gonadal sex and temperature independently influence germ cell differentiation and meiotic progression in Trachemys scripta.
Hatkevich, T., Tezak, B.M., Acemel, R.D., Yee Chung, V.W., Lupiáñez, D.G. and Capel, B.
Proceedings of the National Academy of Sciences of the United States of America 122
(1): e2413191121.
7 January 2025
2024
Architecture of the Sap S-layer of Bacillus anthracis revealed by integrative structural biology.
Sogues, A., Leigh, K., Halingstad, E.V., Van der Verren, S.E., Cecil, A.J., Fioravanti, A., Pak, A.J., Kudryashev, M. and Remaut, H.
Proceedings of the National Academy of Sciences of the United States of America 121
(51): e2415351121.
17 December 2024
Molecular architecture of synaptic vesicles.
Kravčenko, U., Ruwolt, M., Kroll, J., Yushkevich, A., Zenkner, M., Ruta, J., Lotfy, R., Wanker, E.E., Rosenmund, C., Liu, F. and Kudryashev, M.
Proceedings of the National Academy of Sciences of the United States of America 121
(49): e2407375121.
3 December 2024
Arabidopsis uses a molecular grounding mechanism and a biophysical circuit breaker to limit floral abscission signaling.
Taylor, I.W., Patharkar, O.R., Mijar, M., Hsu, C.W., Baer, J., Niederhuth, C.E., Ohler, U., Benfey, P.N. and Walker, J.C.
Proceedings of the National Academy of Sciences of the United States of America 121
(44): e2405806121.
29 October 2024
Incomplete transcriptional dosage compensation of chicken and platypus sex chromosomes is balanced by post-transcriptional compensation.
Lister, N.C., Milton, A.M., Patel, H.R., Waters, S.A., Hanrahan, B.J., McIntyre, K.L., Livernois, A.M., Horspool, W.B., Wee, L.K., Ringel, A.R., Mundlos, S., Robson, M.I., Shearwin-Whyatt, L., Grützner, F., Graves, J.A.M., Ruiz-Herrera, A. and Waters, P.D.
Proceedings of the National Academy of Sciences of the United States of America 121
(32): e2322360121.
6 August 2024
IL-33 controls IL-22-dependent antibacterial defense by modulating the microbiota.
Röwekamp, I., Maschirow, L., Rabes, A., Fiocca Vernengo, F., Hamann, L., Heinz, G.A., Mashreghi, M.F., Caesar, S., Milek, M., Fagundes Fonseca, A.C., Wienhold, S.M., Nouailles, G., Yao, L., Mousavi, S., Bruder, D., Boehme, J.D., Puzianowska-Kuznicka, M., Beule, D., Witzenrath, M., Löhning, M., Klose, C.S.N., Heimesaat, M.M., Diefenbach, A. and Opitz, B.
Proceedings of the National Academy of Sciences of the United States of America 121
(22): e2310864121.
28 May 2024
Structure and function of the hippocampal CA3 module.
Sammons, R.P., Vezir, M., Moreno-Velasquez, L., Cano, G., Orlando, M., Sievers, M., Grasso, E., Metodieva, V.D., Kempter, R., Schmidt, H. and Schmitz, D.
Proceedings of the National Academy of Sciences of the United States of America 121
(6): e2312281120.
6 February 2024
A recent gibbon ape leukemia virus germline integration in a rodent from New Guinea.
Mottaghinia, S., Stenzel, S., Tsangaras, K., Nikolaidis, N., Laue, M., Müller, K., Hölscher, H., Löber, U., McEwen, G.K., Donnellan, S.C., Rowe, K.C., Aplin, K.P., Goffinet, C. and Greenwood, A.D.
Proceedings of the National Academy of Sciences of the United States of America 121
(6): e2220392121.
1 February 2024
2023
Germline C1GALT1C1 mutation causes a multisystem chaperonopathy.
Erger, F., Aryal, R.P., Reusch, B., Matsumoto, Y., Meyer, R., Zeng, J., Knopp, C., Noel, M., Muerner, L., Wenzel, A., Kohl, S., Tschernoster, N., Rappl, G., Rouvet, I., Schröder-Braunstein, J., Seibert, F.S., Thiele, H., Häusler, M.G., Weber, L.T., Büttner-Herold, M., Elbracht, M., Cummings, S.F., Altmüller, J., Habbig, S., Cummings, R.D. and Beck, B.B.
Proceedings of the National Academy of Sciences of the United States of America 120
(22): e2211087120.
30 May 2023
TapA acts as specific chaperone in TasA filament formation by strand complementation.
Roske, Y., Lindemann, F., Diehl, A., Cremer, N., Higman, V.A., Schlegel, B., Leidert, M., Driller, K., Turgay, K., Schmieder, P., Heinemann, U. and Oschkinat, H.
Proceedings of the National Academy of Sciences of the United States of America 120
(17): e2217070120.
25 April 2023
Mouse models of human multiple myeloma subgroups.
Winkler, W., Farré Díaz, C., Blanc, E., Napieczynska, H., Langner, P., Werner, M., Walter, B., Wollert-Wulf, B., Yasuda, T., Heuser, A., Beule, D., Mathas, S., Anagnostopoulos, I., Rosenwald, A., Rajewsky, K. and Janz, M.
Proceedings of the National Academy of Sciences of the United States of America 120
(10): e2219439120.
7 March 2023
Structural remodeling of AAA+ ATPase p97 by adaptor protein ASPL facilitates posttranslational methylation by METTL21D.
Petrović, S., Roske, Y., Rami, B., Phan, M.H.Q., Panakova, D. and Heinemann, U.
Proceedings of the National Academy of Sciences of the United States of America 120
(4): e2208941120.
24 January 2023
2022
Different classes of genomic inserts contribute to human antibody diversity.
Lebedin, M., Foglierini, M., Khorkova, S., Vázquez García, C., Ratswohl, C., Davydov, A.N., Turchaninova, M.A., Daubenberger, C., Chudakov, D.M., Lanzavecchia, A. and de la Rosa, K.
Proceedings of the National Academy of Sciences of the United States of America 119
(36): e2205470119.
6 September 2022
Widespread hydroxylation of unstructured lysine-rich protein domains by JMJD6.
Cockman, M.E., Sugimoto, Y., Pegg, H.B., Masson, N., Salah, E., Tumber, A., Flynn, H.R., Kirkpatrick, J.M., Schofield, C.J. and Ratcliffe, P.J.
Proceedings of the National Academy of Sciences of the United States of America 119
(32): e2201483119.
9 August 2022
Functional modulation of PTH1R activation and signaling by RAMP2.
Nemec, K., Schihada, H., Kleinau, G., Zabel, U., Grushevsky, E.O., Scheerer, P., Lohse, M.J. and Maiellaro, I.
Proceedings of the National Academy of Sciences of the United States of America 119
(32): e2122037119.
9 August 2022
Ablation of lysophosphatidic acid receptor 1 attenuates hypertrophic cardiomyopathy in a mouse model.
Axelsson Raja, A., Wakimoto, H., DeLaughter, D.M., Reichart, D., Gorham, J., Conner, D.A., Lun, M., Probst, C.K., Sakai, N., Knipe, R.S., Montesi, S.B., Shea, B., Adam, L.P., Leinwand, L.A., Wan, W., Choi, E.S., Lindberg, E.L., Patone, G., Noseda, M., Hübner, N., Seidman, C.E., Tager, A.M., Seidman, J.G. and Ho, C.Y.
Proceedings of the National Academy of Sciences of the United States of America 119
(28): e2204174119.
12 July 2022
Brain-wide interactions during hippocampal sharp wave ripples.
Nitzan, N., Swanson, R., Schmitz, D. and Buzsáki, G.
Proceedings of the National Academy of Sciences of the United States of America 119
(20): e2200931119.
17 May 2022
NOXA expression drives synthetic lethality to RUNX1 inhibition in pancreatic cancer.
Doffo, J., Bamopoulos, S.A., Köse, H., Orben, F., Zang, C., Pons, M., den Dekker, A.T., Brouwer, R.W.W., Baluapuri, A., Habringer, S., Reichert, M., Illendula, A., Krämer, O.H., Schick, M., Wolf, E., van IJcken, W.F.J., Esposito, I., Keller, U., Schneider, G. and Wirth, M.
Proceedings of the National Academy of Sciences of the United States of America 119
(9): e2105691119.
1 March 2022
2021
ENHANCED GRAVITROPISM 2 encodes a STERILE ALPHA MOTIF–containing protein that controls root growth angle in barley and wheat.
Kirschner, G.K., Rosignoli, S., Guo, L., Vardanega, I., Imani, J., Altmüller, J., Milner, S.G., Balzano, R:, Nagel, K.A., Pflugfelder, D., Forestan, C., Bovina, R., Koller, R., Stöcker, T.G., Mascher, M., Simmonds, J., Uauy, C., Schoof, H., Tuberosa, R., Salvi, S. and Hochholdinger, F.
Proceedings of the National Academy of Sciences of the United States of America 118
(35): e2101526118.
31 August 2021
The magnitude of germinal center reactions is restricted by a fixed number of preexisting niches.
Avancena, P., Song, T., Yao, Y., Fehlner-Peach, H., Diamond, B., Gu, H., Rajewsky, K. and Zou, Y.R.
Proceedings of the National Academy of Sciences of the United States of America 118
(30): e2100576118.
27 July 2021
Quantification and demonstration of the collective constriction-by-ratchet mechanism in the dynamin molecular motor.
Ganichkin, O.M., Vancraenenbroeck, R., Rosenblum, G., Hofmann, H., Mikhailov, A.S., Daumke, O. and Noel, J.K.
Proceedings of the National Academy of Sciences of the United States of America 118
(28): e2101144118.
13 July 2021
Skin sodium is increased in male patients with multiple sclerosis and related animal models.
Huhn, K., Linz, P., Pemsel, F., Michalke, B., Seyferth, S., Kopp, C., Chaudri, M.A., Rothhammer, V., Dörfler, A., Uder, M., Nagel, A.M., Müller, D.N., Waschbisch, A., Lee, D.H., Bäuerle, T., Linker, R.A. and Haase, S.
Proceedings of the National Academy of Sciences of the United States of America 118
(28): e2102549118.
13 July 2021
Visualization of β-adrenergic receptor dynamics and differential localization in cardiomyocytes.
Bathe-Peters, M., Gmach, P., Boltz, H.H., Einsiedel, J., Gotthardt, M., Hübner, H., Gmeiner, P., Lohse, M.J. and Annibale, P.
Proceedings of the National Academy of Sciences of the United States of America 118
(23): e2101119118.
8 June 2021
High Yap and Mll1 promote a persistent regenerative cell state induced by Notch signaling and loss of p53.
Heuberger, J., Grinat, J., Kosel, F., Liu, L., Kunz, S., Vidal, R.O., Keil, M., Haybaeck, J., Robine, S., Louvard, D., Regenbrecht, C., Sporbert, A., Sauer, S., von Eyss, B., Sigal, M. and Birchmeier, W.
Proceedings of the National Academy of Sciences of the United States of America 118
(22): e2019699118.
1 June 2021
Reconstitution of β-adrenergic regulation of Ca(V)1.2: Rad-dependent and Rad-independent protein kinase A mechanisms.
Katz, M., Subramaniam, S., Chomsky-Hecht, O., Tsemakhovich, V., Flockerzi, V., Klussmann, E., Hirsch, J.A., Weiss, S. and Dascal, N.
Proceedings of the National Academy of Sciences of the United States of America 118
(21): e2100021118.
17 May 2021
Enhanced Ca(2+) signaling, mild primary aldosteronism, and hypertension in a familial hyperaldosteronism mouse model (Cacna1h(M1560V/+)).
Seidel, E., Schewe, J., Zhang, J., Dinh, H.A., Forslund, S.K., Markó, L., Hellmig, N., Peters, J., Muller, D.N., Lifton, R.P., Nottoli, T., Stölting, G. and Scholl, U.I.
Proceedings of the National Academy of Sciences of the United States of America 118
(17): e2014876118.
27 April 2021
DNA origami demonstrate the unique stimulatory power of single pMHCs as T cell antigens.
Hellmeier, J., Platzer, R., Eklund, A.S., Schlichthaerle, T., Karner, A., Motsch, V., Schneider, M.C., Kurz, E., Bamieh, V., Brameshuber, M., Preiner, J., Jungmann, R., Stockinger, H., Schütz, G.J., Huppa, J.B. and Sevcsik, E.
Proceedings of the National Academy of Sciences of the United States of America 118
(4): e2016857118.
26 January 2021
On the adhesion-velocity relation and length adaptation of motile cells on stepped fibronectin lanes.
Schreiber, C., Amiri, B., Heyn, J.C.J., Rädler, J.O. and Falcke, M.
Proceedings of the National Academy of Sciences of the United States of America 118
(4): e2009959118.
26 January 2021
A CRISPR-Cas9-engineered mouse model for GPI-anchor deficiency mirrors human phenotypes and exhibits hippocampal synaptic dysfunctions.
Rodríguez de los Santos, M., Rivalan, M., David, F.S., Stumpf, A., Pitsch, J., Tsortouktzidis, D., Velasquez, L.M., Voigt, A., Schilling, K., Mattei, D., Long, M., Vogt, G., Knaus, A., Fischer-Zirnsak, B., Wittler, L., Timmermann, B., Robinson, P.N., Horn, D., Mundlos, S., Kornak, U., Becker, A.J., Schmitz, D., Winter, Y. and Krawitz, P.M.
Proceedings of the National Academy of Sciences of the United States of America 118
(2): e2014481118.
12 January 2021
Sunlight exposure exerts immunomodulatory effects to reduce multiple sclerosis severity.
Ostkamp, P., Salmen, A., Pignolet, B., Görlich, D., Andlauer, T.F.M., Schulte-Mecklenbeck, A., Gonzalez-Escamilla, G., Bucciarelli, F., Gennero, I., Breuer, J., Antony, G., Schneider-Hohendorf, T., Mykicki, N., Bayas, A., Then Bergh, F., Bittner, S., Hartung, H.P., Friese, M.A., Linker, R.A., Luessi, F., Lehmann-Horn, K., Mühlau, M., Paul, F., Stangel, M., Tackenberg, B., Tumani, H., Warnke, C., Weber, F., Wildemann, B., Zettl, U.K., Ziemann, U., Müller-Myhsok, B., Kümpfel, T., Klotz, L., Meuth, S.G., Zipp, F., Hemmer, B., Hohlfeld, R., Brassat, D., Gold, R., Gross, C.C., Lukas, C., Groppa, S., Loser, K., Wiendl, H. and Schwab, N.
Proceedings of the National Academy of Sciences of the United States of America 118
(1): e2018457118.
5 January 2021
2020
Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells.
Barone, M., Müller, M., Chiha, S., Ren, J., Albat, D., Soicke, A., Dohmen, S., Klein, M., Bruns, J., van Dinther, M., Opitz, R., Lindemann, P., Beerbaum, M., Motzny, K., Roske, Y., Schmieder, P., Volkmer, R., Nazaré, M., Heinemann, U., Oschkinat, H., Ten Dijke, P., Schmalz, H.G. and Kühne, R.
Proceedings of the National Academy of Sciences of the United States of America 117
(47): 29684-29690.
24 November 2020
Advanced fluorescence microscopy reveals disruption of dynamic CXCR4 dimerization by subpocket-specific inverse agonists.
Işbilir, A., Möller, J., Arimont, M., Bobkov, V., Perpiñá-Viciano, C., Hoffmann, C., Inoue, A., Heukers, R., de Graaf, C., Smit, M.J., Annibale, P. and Lohse, M.J.
Proceedings of the National Academy of Sciences of the United States of America 117
(46): 29144-29154.
17 November 2020
The transcription factor C/EBPβ orchestrates dendritic cell maturation and functionality under homeostatic and malignant conditions.
Scholz, F., Grau, M., Menzel, L., Graband, A., Zapukhlyak, M., Leutz, A., Janz, M., Lenz, G., Rehm, A. and Höpken, U.E.
Proceedings of the National Academy of Sciences of the United States of America 117
(42): 26328-26339.
20 October 2020
Functional interplay of Epstein-Barr virus oncoproteins in a mouse model of B cell lymphomagenesis.
Sommermann, T., Yasuda, T., Ronen, J., Wirtz, T., Weber, T., Sack, U., Caeser, R., Zhang, J., Li, X., Chu, V.T., Jauch, A., Unger, K., Hodson, D.J., Akalin, A. and Rajewsky, K.
Proceedings of the National Academy of Sciences of the United States of America 117
(25): 14421-14432.
23 June 2020
EHD2-mediated restriction of caveolar dynamics regulates cellular fatty acid uptake.
Matthaeus, C., Lahmann, I., Kunz, S., Jonas, W., Melo, A.A., Lehmann, M., Larsson, E., Lundmark, R., Kern, M., Blüher, M., Olschowski, H., Kompa, J., Brügger, B., Müller, D.N., Haucke, V., Schürmann, A., Birchmeier, C. and Daumke, O.
Proceedings of the National Academy of Sciences of the United States of America 117
(13): 7471-7481.
31 March 2020
Impaired endothelium-mediated cerebrovascular reactivity promotes anxiety and respiration disorders in mice.
Wenzel, J., Hansen, C.E., Bettoni, C., Vogt, M.A., Lembrich, B., Natsagdorj, R., Huber, G., Brands, J., Schmidt, K., Assmann, J.C., Stölting, I., Saar, K., Sedlacik, J., Fiehler, J., Ludewig, P., Wegmann, M., Feller, N., Richter, M., Müller-Fielitz, H., Walther, T., König, G.M., Kostenis, E., Raasch, W., Hübner, N., Gass, P., Offermanns, S., de Wit, C., Wagner, C.A. and Schwaninger, M.
Proceedings of the National Academy of Sciences of the United States of America 117
(3): 1753-1761.
21 January 2020
2019
Resolving titin's lifecycle and the spatial organization of protein turnover in mouse cardiomyocytes.
Rudolph, F., Hüttemeister, J., da Silva Lopes, K., Jüttner, R., Yu, L., Bergmann, N., Friedrich, D., Preibisch, S., Wagner, E., Lehnart, S.E., Gregorio, C.C. and Gotthardt, M.
Proceedings of the National Academy of Sciences of the United States of America 116
(50): 25126-25136.
10 December 2019
Human-specific tandem repeat expansion and differential gene expression during primate evolution.
Sulovari, A., Li, R., Audano, P.A., Porubsky, D., Vollger, M.R., Logsdon, G.A., Warren, W.C., Pollen, A.A., Chaisson, M.J.P. and Eichler, E.E.
Proceedings of the National Academy of Sciences of the United States of America 116
(46): 23243-23253.
12 November 2019
Atp6ap2 deletion causes extensive vacuolation that consumes the insulin content of pancreatic β cells.
Binger, K.J., Neukam, M., Tattikota, S.G., Qadri, F., Puchkov, D., Willmes, D.M., Wurmsee, S., Geisberger, S., Dechend, R., Raile, K., Kurth, T., Nguyen, G., Poy, M.N., Solimena, M., Muller, D.N. and Birkenfeld, A.L.
Proceedings of the National Academy of Sciences of the United States of America 116
(40): 19983-19988.
1 October 2019
How drag sharpens a T cell's view on antigen.
Schütz, G.J. and Huppa, J.B.
Proceedings of the National Academy of Sciences of the United States of America 116
(34): 16669-16671.
20 August 2019
Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases.
Omar, F., Findlay, J.E., Carfray, G., Allcock, R.W., Jiang, Z., Moore, C., Muir, A.L., Lannoy, M., Fertig, B.A., Mai, D., Day, J.P., Bolger, G., Baillie, G.S., Schwiebert, E., Klussmann, E., Pyne, N.J., Ong, A.C.M., Bowers, K., Adam, J.M., Adams, D.R., Houslay, M.D. and Henderson, D.J.P.
Proceedings of the National Academy of Sciences of the United States of America 116
(27): 13320-13329.
2 July 2019
Preformed chromatin topology assists transcriptional robustness of Shh during limb development.
Paliou, C., Guckelberger, P., Schöpflin, R., Heinrich, V., Esposito, A., Chiariello, A.M., Bianco, S., Annunziatella, C., Helmuth, J., Haas, S., Jerković, I., Brieske, N., Wittler, L., Timmermann, B., Nicodemi, M., Vingron, M., Mundlos, S. and Andrey, G.
Proceedings of the National Academy of Sciences of the United States of America 116
(25): 12390-12399.
18 June 2019
Insights into IgM-mediated complement activation based on in situ structures of IgM-C1-C4b.
Sharp, T.H., Boyle, A.L., Diebolder, C.A., Kros, A., Koster, A. and Gros, P.
Proceedings of the National Academy of Sciences of the United States of America 116
(24): 11900-11905.
11 June 2019
Stepwise activation of a class C GPCR begins with millisecond dimer rearrangement.
Grushevskyi, E.O., Kukaj, T., Schmauder, R., Bock, A., Zabel, U., Schwabe, T., Benndorf, K. and Lohse, M.J.
Proceedings of the National Academy of Sciences of the United States of America 116
(20): 10150-10155.
14 May 2019
MAPK pathway and B cells overactivation in multiple sclerosis revealed by phosphoproteomics and genomic analysis.
Kotelnikova, E., Kiani, N.A., Messinis, D., Pertsovskaya, I., Pliaka, V., Bernardo-Faura, M., Rinas, M., Vila, G., Zubizarreta, I., Pulido-Valdeolivas, I., Sakellaropoulos, T., Faigle, W., Silberberg, G., Masso, M., Stridh, P., Behrens, J., Olsson, T., Martin, R., Paul, F., Alexopoulos, L.G., Saez-Rodriguez, J., Tegner, J. and Villoslada, P.
Proceedings of the National Academy of Sciences of the United States of America 116
(19): 9671-9676.
7 May 2019
2018
Mutation in LBX1/Lbx1 precludes transcription factor cooperativity and causes congenital hypoventilation in humans and mice.
Hernandez-Miranda, L.R., Ibrahim, D.M., Ruffault, P.L., Larrosa, M., Balueva, K., Müller, T., de Weerd, W., Stolte-Dijkstra, I., Hostra, R.M.W., Brunet, J.F., Fortin, G., Mundlos, S. and Birchmeier, C.
Proceedings of the National Academy of Sciences of the United States of America 115
(51): 13021-13026.
18 December 2018
Atomistic simulations indicate the functional loop-to-coiled-coil transition in influenza hemagglutinin is not downhill.
Lin, X., Noel, J.K., Wang, Q., Ma, J. and Onuchic, J.N.
Proceedings of the National Academy of Sciences of the United States of America 115
(34): E7905-E7913.
21 August 2018
Degradation and remobilization of endogenous retroviruses by recombination during the earliest stages of a germ-line invasion.
Löber, U., Hobbs, M., Dayaram, A., Tsangaras, K., Jones, K., Alquezar-Planas, D.E., Ishida, Y., Meers, J., Mayer, J., Quedenau, C., Chen, W., Johnson, R.N., Timms, P., Young, P.R., Roca, A.L. and Greenwood, A.D.
Proceedings of the National Academy of Sciences of the United States of America 115
(34): 8609-8614.
21 August 2018
Structural changes of TasA in biofilm formation of Bacillus subtilis.
Diehl, A., Roske, Y., Ball, L., Chowdhury, A., Hiller, M., Molière, N., Kramer, R., Stöppler, D., Worth, C.L., Schlegel, B., Leidert, M., Cremer, N., Erdmann, N., Lopez, D., Stephanowitz, H., Krause, E., van Rossum, B.J., Schmieder, P., Heinemann, U., Turgay, K., Akbey, Ü. and Oschkinat, H.
Proceedings of the National Academy of Sciences of the United States of America 115
(13): 3237-3242.
27 March 2018
Karyopherin α-3 is a key protein in the pathogenesis of spinocerebellar ataxia type 3 controlling the nuclear localization of ataxin-3.
Sowa, A.S., Martin, E., Martins, I.M., Schmidt, J., Depping, R., Weber, J.J., Rother, F., Hartmann, E., Bader, M., Riess, O., Tricoire, H. and Schmidt, T.
Proceedings of the National Academy of Sciences of the United States of America 115
(11): E2624-E2633.
13 March 2018
Signaling by the Epstein-Barr virus LMP1 protein induces potent cytotoxic CD4(+) and CD8(+) T cell responses.
Choi, I.K., Wang, Z., Ke, Q., Hong, M., Qian, Y., Zhao, X., Liu, Y., Kim, H.J., Ritz, J., Cantor, H., Rajewsky, K., Wucherpfennig, K.W. and Zhang, B.
Proceedings of the National Academy of Sciences of the United States of America 115
(4): E686-E695.
January 2018
2017
Dual origin of enteric neurons in vagal Schwann cell precursors and the sympathetic neural crest.
Espinosa-Medina, I., Jevans, B., Boismoreau, F., Chettouh, Z., Enomoto, H., Müller, T., Birchmeier, C., Burns, Alan J and Brunet, J.F.
Proceedings of the National Academy of Sciences of the United States of America 114
(45): 11980-11985.
7 November 2017
Necroptosis controls NET generation and mediates complement activation, endothelial damage, and autoimmune vasculitis.
Schreiber, A., Rousselle, A., Becker, J.U., von Mässenhausen, A., Linkermann, A. and Kettritz, R.
Proceedings of the National Academy of Sciences of the United States of America 114
(45): E9618-E9625.
7 November 2017
Identification of individuals by trait prediction using
whole-genome sequencing data.
Lippert, C., Sabatini, R., Maher, M.C., Kang, E.Y., Lee, S., Arikan, O., Harley, A., Bernal, A., Garst, P., Lavrenko, V., Yocum, K., Wong, T., Zhu, M., Yang, W.Y., Chang, C., Lu, T., Lee, C.W.H., Hicks, B., Ramakrishnan, S., Tang, H., Xie, C., Piper, J., Brewerton, S., Turpaz, Y., Telenti, A., Roby, R.K., Och, F.J. and Venter, J.C.
Proceedings of the National Academy of Sciences of the United States of America 114
(38): 10166-10171.
19 September 2017
Cytochrome P450 monooxygenase lipid metabolites are significant second messengers in the resolution of choroidal neovascularization.
Hasegawa, E., Inafuku, S., Mulki, L., Okunuki, Y., Yanai, R., Smith, K.E., Kim, C.B., Klokman, G., Bielenberg, D.R., Puli, N., Falck, J.R., Husain, D., Miller, J.W., Edin, M.L., Zeldin, D.C., Lee, K.S.S., Hammock, B.D., Schunck, W.H. and Connor, K.M.
Proceedings of the National Academy of Sciences of the United States of America 114
(36): E7545-E7553.
5 September 2017
Genetic identification of a hindbrain nucleus essential for innate vocalization.
Hernandez-Miranda, L.R., Ruffault, P.L., Bouvier, J.C., Murray, A.J., Morin-Surun, M.P., Zampieri, N., Cholewa-Waclaw, J.B., Ey, E., Brunet, J.F., Champagnat, J., Fortin, G. and Birchmeier, C.
Proceedings of the National Academy of Sciences of the United States of America 114
(30): 8095-8100.
25 July 2017
Structural insights into the activation mechanism of dynamin-like EHD ATPases.
Melo, A.A., Hegde, B.G., Shah, C., Larsson, E., Isas, J.M., Kunz, S., Lundmark, R., Langen, R. and Daumke, O.
Proceedings of the National Academy of Sciences of the United States of America 114
(22): 5629-5634.
30 May 2017
Probing the lithium-response pathway in hiPSCs implicates the phosphoregulatory set-point for a cytoskeletal modulator in bipolar pathogenesis.
Tobe, B.T.D., Crain, A.M., Winquist, A.M., Calabrese, B., Makihara, H., Zhao, W.N., Lalonde, J., Nakamura, H., Konopaske, G., Sidor, M., Pernia, C.D., Yamashita, N., Wada, M., Inoue, Y., Nakamura, F., Sheridan, S.D., Logan, R.W., Brandel, M., Wu, D., Hunsberger, J., Dorsett, L., Duerr, C., Basa, R.C.B., McCarthy, M.J., Udeshi, N.D., Mertins, P., Carr, S.A., Rouleau, G.A., Mastrangelo, L., Li, J., Gutierrez, G.J., Brill, L.M., Venizelos, N., Chen, G., Nye, J.S., Manji, H., Price, J.H., McClung, C.A., Akiskal, H.S., Alda, M., Chuang, D.M.M., Coyle, J.T., Liu, Y., Teng, Y.D., Ohshima, T., Mikoshiba, K., Sidman, R.L., Halpain, S., Haggarty, S.J., Goshima, Y. and Snyder, E.Y.
Proceedings of the National Academy of Sciences of the United States of America 114
(22): E4462-E4471.
30 May 2017
Data-based modeling of drug penetration relates human skin barrier function to the interplay of diffusivity and free-energy profiles.
Schulz, R., Yamamoto, K., Klossek, A., Flesch, R., Hönzke, S., Rancan, F., Vogt, A., Blume-Peytavi, U., Hedtrich, S., Schäfer-Korting, M., Rühl, E. and Netz, R.R.
Proceedings of the National Academy of Sciences of the United States of America 114
(14): 3631-3636.
4 April 2017
George Klein: 1925-2016.
Rajewsky, K.
National Academy of Sciences.
28 March 2017
2016
Role of the receptor Mas in macrophage-mediated inflammation in vivo.
Hammer, A., Yang, G., Friedrich, J., Kovacs, A., Lee, D.H., Grave, K., Jörg, S., Alenina, N., Grosch, J., Winkler, J., Gold, R., Bader, M., Manzel, A., Rump, L.C., Müller, D.N., Linker, R.A. and Stegbauer, J.
Proceedings of the National Academy of Sciences of the United States of America 113
(49): 14109-14114.
6 December 2016
Mouse model for acute Epstein-Barr virus infection.
Wirtz, T., Weber, T., Kracker, S., Sommermann, T., Rajewsky, K. and Yasuda, T.
Proceedings of the National Academy of Sciences of the United States of America 113
(48): 13821-13826.
29 November 2016
Stress-induced brain activity, brain atrophy, and clinical disability in multiple sclerosis.
Weygandt, M., Meyer-Arndt, L., Behrens, J.R., Wakonig, K., Bellmann-Strobl, J., Ritter, K., Scheel, M., Brandt, A.U., Labadie, C., Hetzer, S., Gold, S.M., Paul, F. and Haynes, J.D.
Proceedings of the National Academy of Sciences of the United States of America 113
(47): 13444-13449.
22 November 2016
Super-resolution ribosome profiling reveals unannotated translation events in Arabidopsis.
Hsu, P.Y., Calviello, L., Wu, H.Y.L., Li, F.W., Rothfels, C.J., Ohler, U. and Benfey, P.N.
Proceedings of the National Academy of Sciences of the United States of America 113
(45): E7126-E7135.
8 November 2016
Efficient CRISPR-mediated mutagenesis in primary immune cells using CrispRGold and a C57BL/6 Cas9 transgenic mouse line.
Chu, V.T., Graf, R., Wirtz, T., Weber, T., Favret, J., Li, X., Petsch, K., Tran, N.T., Sieweke, M.H., Berek, C., Kühn, R. and Rajewsky, K.
Proceedings of the National Academy of Sciences of the United States of America 113
(44): 12514-12519.
1 November 2016
RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses.
Grauel, M.K., Maglione, M., Reddy-Alla, S., Willmes, C.G., Brockmann, M.M., Trimbuch, T., Rosenmund, T., Pangalos, M., Vardar, G., Stumpf, A., Walter, A.M., Rost, B.R., Eickholt, B.J., Haucke, V., Schmitz, D., Sigrist, S.J. and Rosenmund, C.
Proceedings of the National Academy of Sciences of the United States of America 113
(41): 11615-11620.
11 October 2016
Numerous proteins with unique characteristics are degraded by the 26S proteasome following monoubiquitination.
Braten, O., Livneh, I., Ziv, T., Admon, A., Kehat, I., Caspi, L.H., Gonen, H., Bercovich, B., Godzik, A., Jahandideh, S., Jaroszewski, L., Sommer, T., Kwon, Y.T., Guharoy, M., Tompa, P. and Ciechanover, A.
Proceedings of the National Academy of Sciences of the United States of America 113
(32): E4639-E4647.
9 August 2016
Superpriming of synaptic vesicles as a common basis for intersynapse variability and modulation of synaptic strength.
Taschenberger, H., Woehler, A. and Neher, E.
Proceedings of the National Academy of Sciences of the United States of America 113
(31): E4548-E4557.
2 August 2016
Canonical NF-κB signaling is uniquely required for the long-term persistence of functional mature B cells.
Derudder, E., Herzog, S., Labi, V., Yasuda, T., Köchert, K., Janz, M., Villunger, A., Schmidt-Supprian, M. and Rajewsky, K.
Proceedings of the National Academy of Sciences of the United States of America 113
(18): 5065-5070.
3 May 2016
Tissue-specific DNA demethylation is required for proper B-cell differentiation and function.
Orlanski, S., Labi, V., Reizel, Y., Spiro, A., Lichtenstein, M., Levin-Klein, R., Koralov, S.B., Skversky, Y., Rajewsky, K., Cedar, H. and Bergman, Y.
Proceedings of the National Academy of Sciences of the United States of America 113
(18): 5018-5023.
3 May 2016
Insight into GATA1 transcriptional activity through interrogation of cis elements disrupted in human erythroid disorders.
Wakabayashi, A., Ulirsch, J.C., Ludwig, L.S., Fiorini, C., Yasuda, M., Choudhuri, A., McDonel, P., Zon, L.I. and Sankaran, V.G.
Proceedings of the National Academy of Sciences of the United States of America 113
(16): 4434-4439.
19 April 2016
Extracardiac septum transversum/proepicardial endothelial cells pattern embryonic coronary arterio-venous connections.
Cano, E., Carmona, R., Ruiz-Villalba, A., Rojas, A., Chau, Y.Y., Wagner, K.D., Wagner, N., Hastie, N.D., Munoz-Chapuli, R. and Perez-Pomares, J.M.
Proceedings of the National Academy of Sciences of the United States of America 113
(3): 656-661.
19 January 2016
2015
The B-cell antigen receptor integrates adaptive and innate immune signals.
Otipoby, K.L., Waisman, A., Derudder, E., Srinivasan, L., Franklin, A. and Rajewsky, K.
Proceedings of the National Academy of Sciences of the United States of America 112
(39): 12145-12150.
29 September 2015
A modular toolkit to inhibit proline-rich motif-mediated protein-protein interactions.
Opitz, R., Mueller, M., Reuter, C., Barone, M., Soicke, A., Roske, Y., Piotukh, K., Huy, P., Beerbaum, M., Wiesner, B., Beyermann, M., Schmieder, P., Freund, C., Volkmer, R., Oschkinat, H., Schmalz, H.G. and Kuehne, R.
Proceedings of the National Academy of Sciences of the United States of America 112
(16): 5011-5016.
21 April 2015
VH replacement in primary immunoglobulin repertoire diversification.
Sun, A., Novobrantseva, T.I., Coffre, M., Hewitt, S.L., Jensen, K., Skok, J.A., Rajewsky, K. and Koralov, S.B.
Proceedings of the National Academy of Sciences of the United States of America 112
(5): E458-E466.
3 February 2015
2014
Essential role for autophagy during invariant NKT cell development.
Salio, M., Puleston, D.J., Mathan, T.S.M., Shepherd, D., Stranks, A.J., Adamopoulou, E., Veerapen, N., Besra, G.S., Hollander, G.A., Simon, A.K. and Cerundolo, V.
Proceedings of the National Academy of Sciences of the United States of America 111
(52): E5678-E5687.
30 December 2014
Mapping of transcription factor motifs in active chromatin identifies IRF5 as key regulator in classical Hodgkin lymphoma.
Kreher, S., Bouhlel, M.A., Cauchy, P., Lamprecht, B., Li, S., Grau, M., Hummel, F., Köchert, K., Anagnostopoulos, I., Jöhrens, K., Hummel, M., Hiscott, J., Wenzel, S.S., Lenz, P., Schneider, M., Küppers, R., Scheidereit, C., Giefing, M., Siebert, R., Rajewsky, K., Lenz, G., Cockerill, P.N., Janz, M., Dörken, B., Bonifer, C. and Mathas, S.
Proceedings of the National Academy of Sciences of the United States of America 111
(42): E4513-E4522.
21 October 2014
IKK phosphorylates RelB to modulate its promoter specificity and promote fibroblast migration downstream of TNF receptors.
Authier, H., Billot, K., Derudder, E., Bordereaux, D., Riviere, P., Rodrigues-Ferreira, S., Nahmias, C. and Baud, V.
Proceedings of the National Academy of Sciences of the United States of America 111
(41): 14794-14799.
14 October 2014
Prion-like proteins sequester and suppress the toxicity of huntingtin exon 1.
Kayatekin, C., Matlack, K.E.S., Hesse, W.R., Guan, Y., Chakrabortee, S., Russ, J., Wanker, E.E., Shah, J.V. and Lindquist, S.
Proceedings of the National Academy of Sciences of the United States of America 111
(33): 12085-12090.
19 August 2014
Cytochrome P450-generated metabolites derived from ω-3 fatty acids attenuate neovascularization.
Yanai, R., Mulki, L., Hasegawa, E., Takeuchi, K., Sweigard, H., Suzuki, J., Gaissert, P., Vavvas, D.G., Sonoda, K.H., Rothe, M., Schunck, W.H., Miller, J.W. and Connor, K.M.
Proceedings of the National Academy of Sciences of the United States of America 111
(26): 9603-9608.
1 July 2014
Shp2/MAPK signaling controls goblet/paneth cell fate decisions in the intestine.
Heuberger, J., Kosel, F., Qi, J., Grossmann, K.S., Rajewsky, K. and Birchmeier, W.
Proceedings of the National Academy of Sciences of the United States of America 111
(9): 3472-3477.
4 March 2014
Michael S. Neuberger 1953-2013.
Rajewsky, K.
Proceedings of the National Academy of Sciences of the United States of America 111
(8): 2862-2863.
25 February 2014
Clostridium difficile toxin CDT hijacks microtubule organization and reroutes vesicle traffic to increase pathogen adherence.
Schwan, C., Kruppke, A.S., Nölke, T., Schumacher, L., Koch-Nolte, F., Kudryashev, M., Stahlberg, H. and Aktories, K.
Proceedings of the National Academy of Sciences of the United States of America 111
(6): 2313-2318.
11 February 2014
Electroconvulsive therapy-induced brain plasticity determines therapeutic outcome in mood disorders.
Dukart, J., Regen, F., Kherif, F., Colla, M., Bajbouj, M., Heuser, I., Frackowiak, R.S. and Draganski, B.
Proceedings of the National Academy of Sciences of the United States of America 111
(3): 1156-1161.
21 January 2014
2013
Sox9 plays multiple roles in the lung epithelium during branching morphogenesis.
Rockich, B.E., Hrycaj, S.M., Shih, H.P., Nagy, M.S., Ferguson, M.A.H., Kopp, J.L., Sander, M., Wellik, D.M. and Spence, J.R.
Proceedings of the National Academy of Sciences of the United States of America 110
(47): E4456-64.
19 November 2013
Wnt/Rspondin/β-catenin signals control axonal sorting and lineage progression in Schwann cell development.
Grigoryan, T., Stein, S., Qi, J., Wende, H., Garratt, A.N., Nave, K.A., Birchmeier, C. and Birchmeier, W.
Proceedings of the National Academy of Sciences of the United States of America 110
(45): 18174-18179.
5 November 2013
Reexposure to nicotine during withdrawal increases the pacemaking activity of cholinergic habenular neurons.
Goerlich, A., Antolin-Fontes, B., Ables, J.L., Frahm, S., Slimak, M.A., Dougherty, J.D. and Ibanez-Tallon, I.
Proceedings of the National Academy of Sciences of the United States of America 110
(42): 17077-17082.
15 October 2013
Using machine learning to identify disease-relevant regulatory RNAs.
Ohler, U.
Proceedings of the National Academy of Sciences of the United States of America 110
(39): 15516-15517.
24 September 2013
GABA(B) autoreceptor-mediated cell type-specific reduction of inhibition in epileptic mice.
Dugladze, T., Maziashvili, N., Boergers, C., Gurgenidze, S., Haeussler, U., Winkelmann, A., Haas, C.A., Meier, J.C., Vida, I., Kopell, N.J. and Gloveli, T.
Proceedings of the National Academy of Sciences of the United States of America 110
(37): 15073-15078.
10 September 2013
Neurokinin3 receptor as a target to predict and improve learning and memory in the aged organism.
de Souza Silva, M.A., Lenz, B., Rotter, A., Biermann, T., Peters, O., Ramirez, A., Jessen, F., Maier, W., Huell, M., Schroeder, J., Froelich, L., Teipel, S., Gruber, O., Kornhuber, J., Huston, J.P., Mueller, C.P. and Schaeble, S.
Proceedings of the National Academy of Sciences of the United States of America 110
(37): 15097-15102.
10 September 2013
PTEN loss defines a PI3K/AKT pathway-dependent germinal center subtype of diffuse large B-cell lymphoma.
Pfeifer, M., Grau, M., Lenze, D., Wenzel, S.S., Wolf, A., Wollert-Wulf, B., Dietze, K., Nogai, H., Storek, B., Madle, H., Dörken, B., Janz, M., Dirnhofer, S., Lenz, P., Hummel, M., Tzankov, A. and Lenz, G.
Proceedings of the National Academy of Sciences of the United States of America 110
(30): 12420-12425.
23 July 2013
Interfering with Gal-1-mediated angiogenesis contributes to the pathogenesis of preeclampsia.
Freitag, N., Tirado-González, I., Barrientos, G., Herse, F., Thijssen, V.L.J.L., Weedon-Fekjær, S.M., Schulz, H., Wallukat, G., Klapp, B.F., Nevers, T., Sharma, S., Staff, A.C., Dechend, R. and Blois, S.M.
Proceedings of the National Academy of Sciences of the United States of America 110
(28): 11451-11456.
9 July 2013
Histone deacetylase 10 promotes autophagy-mediated cell survival.
Oehme, I., Linke, J.P., Böck, B.C., Milde, T., Lodrini, M., Hartenstein, B., Wiegand, I., Eckert, C., Roth, W., Kool, M., Kaden, S., Gröne, H.J., Schulte, J.H., Lindner, S., Hamacher-Brady, A., Brady, N.R., Deubzer, H.E. and Witt, O.
Proceedings of the National Academy of Sciences of the United States of America 110
(28): E2592-E2601.
9 July 2013
Inhibition of TFG function causes hereditary axon degeneration by impairing endoplasmic reticulum structure.
Beetz, C., Johnson, A., Schuh, A.L., Thakur, S., Varga, R.E., Fothergill, T., Hertel, N., Bomba-Warczak, E., Thiele, H., Nürnberg, G., Altmüller, J., Saxena, R., Chapman, E.R., Dent, E.W., Nürnberg, P. and Audhya, A.
Proceedings of the National Academy of Sciences of the United States of America 110
(13): 5091-5096.
26 March 2013
Recruitment of oriens-lacunosum-moleculare interneurons during hippocampal ripples.
Pangalos, M., Donoso, J.R., Winterer, J., Zivkovic, A.R., Kempter, R., Maier, N. and Schmitz, D.
Proceedings of the National Academy of Sciences of the United States of America 110
(11): 4398-4403.
12 March 2013
Colony-forming cells in the adult mouse pancreas are expandable in Matrigel and form endocrine/acinar colonies in laminin hydrogel.
Jin, L., Feng, T., Shih, H.P., Zerda, R., Luo, A., Hsu, J., Mahdavi, A., Sander, M., Tirrell, D.A., Riggs, A.D. and Ku, H.T.
Proceedings of the National Academy of Sciences of the United States of America 110
(10): 3907-12.
5 March 2013
Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides.
Wefers, B., Meyer, M., Ortiz, O., Hrabé de Angelis, M., Hansen, J., Wurst, W. and Kühn, R.
Proceedings of the National Academy of Sciences of the United States of America 110
(10): 3782-3787.
5 March 2013
Compromised fidelity of endocytic synaptic vesicle protein sorting in the absence of stonin 2.
Kononenko, N.L., Diril, M.K., Puchkov, D., Kintscher, M., Koo, S.J., Pfuhl, G., Winter, Y., Wienisch, M., Klingauf, J., Breustedt, J., Schmitz, D., Maritzen, T. and Haucke, V.
Proceedings of the National Academy of Sciences of the United States of America 110
(6): E526-E535.
5 February 2013
Fas expression by tumor stroma is required for cancer eradication.
Listopad, J.J., Kammertoens, T., Anders, K., Silkenstedt, B., Willimsky, G., Schmidt, K., Kuehl, A.A., Loddenkemper, C. and Blankenstein, T.
Proceedings of the National Academy of Sciences of the United States of America 110
(6): 2276-2281.
5 February 2013
Borna disease virus-induced neuronal degeneration dependent on host genetic background and prevented by soluble factors.
Wu, Y.J., Schulz, H., Lin, C.C., Saar, K., Patone, G., Fischer, H., Hübner, N., Heimrich, B. and Schwemmle, M.
Proceedings of the National Academy of Sciences of the United States of America 110
(5): 1899-1904.
29 January 2013
Insights into the regulation of the human COP9 signalosome catalytic subunit, CSN5/Jab1.
Echalier, A., Pan, Y., Birol, M., Tavernier, N., Pintard, L., Hoh, F., Ebel, C., Galophe, N., Claret, F.X. and Dumas, C.
Proceedings of the National Academy of Sciences of the United States of America 110
(4): 1273-1278.
22 January 2013
2012
Complexity of chromatin folding is captured by the strings and binders switch model.
Barbieri, M., Chotalia, M., Fraser, J., Lavitas, L.M., Dostie, J., Pombo, A. and Nicodemi, M.
Proceedings of the National Academy of Sciences of the United States of America 109
(40): 16173-16178.
2 October 2012
Dependence on nuclear factor of activated T-cells (NFAT) levels discriminates conventional T cells from Foxp3+ regulatory T cells.
Vaeth, M., Schliesser, U., Mueller, G., Reissig, S., Satoh, K., Tuettenberg, A., Jonuleit, H., Waisman, A., Mueller, M.R., Serfling, E., Sawitzki, B.S. and Berberich-Siebelt, F.
Proceedings of the National Academy of Sciences of the United States of America 109
(40): 16258-16263.
2 October 2012
Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2.
Greulich, H., Kaplan, B., Mertins, P., Chen, T.H., Tanaka, K.E., Yun, C.H., Zhang, X., Lee, S.H., Cho, J., Ambrogio, L., Liao, R., Imielinski, M., Banerji, S., Berger, A.H., Lawrence, M.S., Zhang, J., Pho, N.H., Walker, S.R., Winckler, W., Getz, G., Frank, D., Hahn, W.C., Eck, M.J., Mani, D.R., Jaffe, J.D., Carr, S.A., Wong, K.K. and Meyerson, M.
Proceedings of the National Academy of Sciences of the United States of America 109
(36): 14476-14481.
4 September 2012
Deletion of claudin-10 (Cldn10) in the thick ascending limb impairs paracellular sodium permeability and leads to hypermagnesemia and nephrocalcinosis.
Breiderhoff, T., Himmerkus, N., Stuiver, M., Mutig, K., Will, C., Meij, I.C., Bachmann, S., Bleich, M., Willnow, T.E. and Mueller, D.
Proceedings of the National Academy of Sciences of the United States of America 109
(35): 14241-14246.
28 August 2012
Cholinergic interneurons in the nucleus accumbens regulate depression-like behavior.
Warner-Schmidt, J.L., Schmidt, E.F., Marshall, J.J., Rubin, A.J., Arango-Lievano, M., Kaplitt, M.G., Ibanez-Tallon, I., Heintz, N. and Greengard, P.
Proceedings of the National Academy of Sciences of the United States of America 109
(28): 11360-11365.
10 July 2012
Wnt/beta-catenin and Bmp signals control distinct sets of transcription factors in cardiac progenitor cells.
Klaus, A., Mueller, M., Schulz, H., Saga, Y., Martin, J.F. and Birchmeier, W.
Proceedings of the National Academy of Sciences of the United States of America 109
(27): 10921-10926.
3 July 2012
Modeling disease mutations by gene targeting in one-cell mouse embryos.
Meyer, M., Ortiz, O., Hrabe de Angelis, M., Wurst, W. and Kuehn, R.
Proceedings of the National Academy of Sciences of the United States of America 109
(24): 9354-9359.
12 June 2012
Amorfrutins are potent antidiabetic dietary natural products.
Weidner, C., de Groot, J.C., Prasad, A., Freiwald, A., Quedenau, C., Kliem, M., Witzke, A., Kodelja, V., Han, C.T., Giegold, S., Baumann, M., Klebl, B., Siems, K., Müller-Kuhrt, L., Schürmann, A., Schüler, R., Pfeiffer, A.F.H., Schroeder, F.C., Büssow, K. and Sauer, S.
Proceedings of the National Academy of Sciences of the United States of America 109
(19): 7257-7262.
8 May 2012
The protein expression landscape of the Arabidopsis root.
Petricka, J.J., Schauer, M.A., Megraw, M., Breakfield, N.W., Thompson, J.W., Georgiev, S., Soderblom, E.J., Ohler, U., Moseley, M.A., Grossniklaus, U. and Benfey, P.N.
Proceedings of the National Academy of Sciences of the United States of America 109
(18): 6811-6818.
1 May 2012
Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages.
Schroder, K., Irvine, K.M., Taylor, M.S., Bokil, N.J., Le Cao, K.A., Masterman, K.A., Labzin, L.I., Semple, C.A., Kapetanovic, R., Fairbairn, L., Akalin, A., Faulkner, G.J., Baillie, J.K., Gongora, M., Daub, C.O., Kawaji, H., McLachlan, G.J., Goldman, N., Grimmond, S.M., Carninci, P., Suzuki, H., Hayashizaki, Y., Lenhard, B., Hume, D.A. and Sweet, M.J.
Proceedings of the National Academy of Sciences of the United States of America 109
(16): E944-E953.
17 April 2012
Phosphorylation-regulated axonal dependent transport of syntaxin 1 is mediated by a Kinesin-1 adapter.
Chua, J.J.E., Butkevich, E., Worseck, J.M., Kittelmann, M., Gronborg, M., Behrmann, E., Stelzl, U., Pavlos, N.J., Lalowski, M.M., Eimer, S., Wanker, E.E., Klopfenstein, D.R. and Jahn, R.
Proceedings of the National Academy of Sciences of the United States of America 109
(15): 5862-5867.
10 April 2012
Ectodysplasin regulates hormone-independent mammary ductal morphogenesis via NF-κB.
Voutilainen, M., Lindfors, P.H., Lefebvre, S., Ahtiainen, L., Fliniaux, I., Rysti, E., Murtoniemi, M., Schneider, P., Schmidt-Ullrich, R. and Mikkola, M.L.
Proceedings of the National Academy of Sciences of the United States of America 109
(15): 5744-5749.
10 April 2012
2011
Homeoprotein Phox2b commands a somatic-to-visceral switch in cranial sensory pathways.
D'Autreaux, F., Coppola, E., Hirsch, M.R., Birchmeier, C. and Brunet, J.F.
Proceedings of the National Academy of Sciences of the United States of America 108
(50): 20018-20023.
13 December 2011
Interaction of complexes I, III, and IV within the bovine respirasome by single particle cryoelectron tomography.
Dudkina, N.V., Kudryashev, M., Stahlberg, H. and Boekema, E.J.
Proceedings of the National Academy of Sciences of the United States of America 108
(37): 15196-15200.
13 September 2011
Cellular correlate of assembly formation in oscillating hippocampal networks in vitro.
Baehner, F., Weiss, E.K., Birke, G., Maier, N., Schmitz, D., Rudolph, U., Frotscher, M., Traub, R.D., Both, M. and Draguhn, A.
Proceedings of the National Academy of Sciences of the United States of America 108
(35): E607-E616.
30 August 2011
Malt1-dependent RelB cleavage promotes canonical NF-κB activation in lymphocytes and lymphoma cell lines.
Hailfinger, S., Nogai, H., Pelzer, C., Jaworski, M., Cabalzar, K., Charton, J.E., Guzzardi, M., Decaillet, C., Grau, M., Doerken, B., Lenz, P., Lenz, G. and Thome, M.
Proceedings of the National Academy of Sciences of the United States of America 108
(35): 14596-14601.
30 August 2011
SNARE motif-mediated sorting of synaptobrevin by the endocytic adaptors clathrin assembly lymphoid myeloid leukemia (CALM) and AP180 at synapses.
Koo, S.J., Markovic, S., Puchkov, D., Mahrenholz, C.C., Beceren-Braun, F., Maritzen, T., Dernedde, J., Volkmer, R., Oschkinat, H. and Haucke, V.
Proceedings of the National Academy of Sciences of the United States of America 108
(33): 13540-13545.
16 August 2011
Cholinergic chemosensory cells in the trachea regulate breathing.
Krasteva, G., Canning, B.J., Hartmann, P., Veres, T.Z., Papadakis, T., Muehlfeld, C., Schliecker, K., Tallini, Y.N., Braun, A., Hackstein, H., Baal, N., Weihe, E., Schuetz, B., Kotlikoff, M., Ibanez-Tallon, I. and Kummer, W.
Proceedings of the National Academy of Sciences of the United States of America 108
(23): 9478-9483.
7 June 2011
Structural insights into membrane fusion at the endoplasmic reticulum.
Daumke, O. and Praefcke, G.J.
Proceedings of the National Academy of Sciences of the United States of America 108
(6): 2175-2176.
8 February 2011
Critical role of PI3K signaling for NF-κB-dependent survival in a subset of activated B-cell-like diffuse large B-cell lymphoma cells.
Kloo, B., Nagel, D., Pfeifer, M., Grau, M., Duewel, M., Vincendeau, M., Doerken, B., Lenz, P., Lenz, G. and Krappmann, D.
Proceedings of the National Academy of Sciences of the United States of America 108
(1): 272-277.
4 January 2011
Derivation of Ca2+ signals from puff properties reveals that pathway function is robust against cell variability but sensitive for control.
Thurley, K. and Falcke, M.
Proceedings of the National Academy of Sciences of the United States of America 108
(1): 427-432.
4 January 2011
2010
Bidirectional binding of invariant chain peptides to an MHC class II molecule.
Guenther, S., Schlundt, A., Sticht, J., Roske, Y., Heinemann, U., Wiesmueller, K.H., Jung, G., Falk, K., Roetzschke, O. and Freund, C.
Proceedings of the National Academy of Sciences of the United States of America 107
(51): 22219-22224.
21 December 2010
Impacting our young.
Marder, E., Kettenmann, H. and Grillner, S.
Proceedings of the National Academy of Sciences of the United States of America 107
(50): 21233.
14 December 2010
Structural basis of oligomerization in septin-like GTPase of immunity-associated protein 2 (GIMAP2).
Schwefel, D., Froehlich, C., Eichhorst, J., Wiesner, B., Behlke, J., Aravind, L. and Daumke, O.
Proceedings of the National Academy of Sciences of the United States of America 107
(47): 20299-20304.
23 November 2010
A synthetic-natural hybrid oscillator in human cells.
Toettcher, J.E., Mock, C., Batchelor, E., Loewer, A. and Lahav, G.
Proceedings of the National Academy of Sciences of the United States of America 107
(39): 17047-17052.
28 September 2010
Highly aneuploid zebrafish malignant peripheral nerve sheath tumors have genetic alterations similar to human cancers.
Zhang, G., Hoersch, S., Amsterdam, A., Whittaker, C.A., Lees, J.A. and Hopkins, N.
Proceedings of the National Academy of Sciences of the United States of America 107
(39): 16940-16945.
28 September 2010
Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases.
Meyer, M., de Angelis, M.H., Wurst, W. and Kühn, R.
Proceedings of the National Academy of Sciences of the United States of America 107
(34): 15022-15026.
24 August 2010
The KCNQ5 potassium channel mediates a component of the afterhyperpolarization current in mouse hippocampus.
Tzingounis, A.V., Heidenreich, M., Kharkovets, T., Spitzmaul, G., Jensen, H.S., Nicoll, R.A. and Jentsch, T.J.
Proceedings of the National Academy of Sciences of the United States of America 107
(22): 10232-10237.
1 June 2010
EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity.
Bieschke, J., Russ, J., Friedrich, R.P., Ehrnhoefer, D.E., Wobst, H., Neugebauer, K. and Wanker, E.E.
Proceedings of the National Academy of Sciences of the United States of America 107
(17): 7710-7715.
27 April 2010
Evidence for a functional sidedness to the (α)(β)TCR.
Kuhns, M.S., Girvin, A.T., Klein, L.O., Chen, R., Jensen, K.D.C., Newell, E.W., Huppa, J.B., Lillemeier, B.F., Huse, M., Chien, Y.H., Garcia, K.C. and Davis, M.M.
Proceedings of the National Academy of Sciences of the United States of America 107
(11): 5094-9.
16 March 2010
Two isoforms of human RNA polymerase III with specific functions in cell growth and transformation.
Haurie, V., Durrieu-Gaillard, S., Dumay-Odelot, H., Da Silva, D., Rey, C., Prochazkova, M., Roeder, R.G., Besser, D. and Teichmann, M.
Proceedings of the National Academy of Sciences of the United States of America 107
(9): 4176-4181.
2 March 2010
Establishment of a neuroepithelial barrier by Claudin5a is essential for zebrafish brain ventricular lumen expansion.
Zhang, J., Piontek, J., Wolburg, H., Piehl, C., Liss, M., Otten, C., Christ, A., Willnow, T.E., Blasig, I.E. and Abdelilah-Seyfried, S.
Proceedings of the National Academy of Sciences of the United States of America 107
(4): 1425-1430.
26 January 2010
Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo.
Mortensen, M., Ferguson, D.J.P., Edelmann, M., Kessler, B., Morten, K.J., Komatsu, M. and Simon, A.K.
Proceedings of the National Academy of Sciences of the United States of America 107
(2): 832-7.
12 January 2010
NCLX is an essential component of mitochondrial Na+/Ca2+ exchange.
Palty, R., Silverman, W.F., Hershfinkel, M., Caporale, T., Sensi, S.L., Parnis, J., Nolte, C., Fishman, D., Shoshan-Barmatz, V., Herrmann, S., Khananshvili, D. and Sekler, I.
Proceedings of the National Academy of Sciences of the United States of America 107
(1): 436-441.
5 January 2010
2009
CCR7-mediated migration of developing thymocytes to the medulla is essential for negative selection to tissue-restricted antigens.
Nitta, T., Nitta, S., Lei, Y., Lipp, M. and Takahama, Y.
Proceedings of the National Academy of Sciences of the United States of America 106
(40): 17129-17133.
6 October 2009
The tyrosine phosphatase Shp2 (PTPN11) directs neuregulin-1/ErbB signaling throughout schwann cell development.
Grossmann, K.S., Wende, H., Paul, F.E., Cheret, C., Garratt, A.N., Zurborg, S., Feinberg, K., Besser, D., Schulz, H., Peles, E., Selbach, M., Birchmeier, W. and Birchmeier, C.
Proceedings of the National Academy of Sciences of the United States of America 106
(39): 16704-16709.
29 September 2009
C-type natriuretic peptide (CNP) is a bifurcation factor for sensory neurons.
Schmidt, H., Stonkute, A., Juettner, R., Koesling, D., Friebe, A. and Rathjen, F.G.
Proceedings of the National Academy of Sciences of the United States of America 106
(39): 16847-16852.
29 September 2009
Role of the renin-angiotensin system in autoimmune inflammation of the central nervous system.
Stegbauer, J., Lee, D.H., Seubert, S., Ellrichmann, G., Manzel, A., Kvakan, H., Mueller, D.N., Gaupp, S., Rump, L.C., Gold, R. and Linker, R.A.
Proceedings of the National Academy of Sciences of the United States of America 106
(35): 14942-14947.
1 September 2009
Single-molecule force spectroscopy distinguishes target binding modes of calmodulin.
Junker, J.P. and Rief, M.
Proceedings of the National Academy of Sciences of the United States of America 106
(34): 14361-14366.
25 August 2009
Host-derived glucose and its transporter in the obligate intracellular pathogen Toxoplasma gondii are dispensable by glutaminolysis.
Blume, M., Rodriguez-Contreras, D., Landfear, S., Fleige, T., Soldati-Favre, D., Lucius, R. and Gupta, N.
Proceedings of the National Academy of Sciences of the United States of America 106
(31): 12998-13003.
4 August 2009
Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion.
Markovic, D.S., Vinnakota, K., Chirasani, S., Synowitz, M., Raguet, H., Stock, K., Sliwa, M., Lehmann, S., Kaelin, R., van Rooijen, N., Holmbeck, K., Heppner, F.L., Kiwit, J., Matyash, V., Lehnardt, S., Kaminska, B., Glass, R. and Kettenmann, H.
Proceedings of the National Academy of Sciences of the United States of America 106
(30): 12530-12535.
28 July 2009
High-resolution profiling and discovery of planarian small RNAs.
Friedlaender, M.R., Adamidi, C., Han, T., Lebedeva, S., Isenbarger, T.A., Hirst, M., Marra, M., Nusbaum, C., Lee, W.L., Jenkin, J.C., Alvarado, A.S., Kim, J.K. and Rajewsky, N.
Proceedings of the National Academy of Sciences of the United States of America 106
(28): 11546-11551.
14 July 2009
Growth retardation and altered autonomic control in mice lacking brain serotonin.
Alenina, N., Kikic, D., Todiras, M., Mosienko, V., Qadri, F., Plehm, R., Boye, P., Vilianovitch, L., Sohr, R., Tenner, K., Hoertnagl, H. and Bader, M.
Proceedings of the National Academy of Sciences of the United States of America 106
(25): 10332-10337.
23 June 2009
Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function.
Wang, S., Jensen, J.N., Seymour, P.A., Hsu, W., Dor, Y., Sander, M., Magnuson, M.A., Serup, P. and Gu, G.
Proceedings of the National Academy of Sciences of the United States of America 106
(24): 9715-20.
16 June 2009
The small G-proteins Rac1 and Cdc42 are essential for myoblast fusion in the mouse.
Vasyutina, E., Martarelli, B., Brakebusch, C., Wende, H. and Birchmeier, C.
Proceedings of the National Academy of Sciences of the United States of America 106
(22): 8935-8940.
2 June 2009
Gene deregulation and spatial genome reorganization near breakpoints prior to formation of translocations in anaplastic large cell lymphoma.
Mathas, S., Kreher, S., Meaburn, K.J., Joehrens, K., Lamprecht, B., Assaf, C., Sterry, W., Kadin, M.E., Daibata, M., Joos, S., Hummel, M., Stein, H., Janz, M., Anagnostopoulos, I., Schrock, E., Misteli, T. and Doerken, B.
Proceedings of the National Academy of Sciences of the United States of America 106
(14): 5831-5836.
7 April 2009
miR-375 maintains normal pancreatic α- and β-cell mass.
Poy, M.N., Hausser, J., Trajkovski, M., Braun, M., Collins, S., Rorsman, P., Zavolan, M. and Stoffel, M.
Proceedings of the National Academy of Sciences of the United States of America 106
(14): 5813-5818.
7 April 2009
A role for LYNX2 in anxiety-related behavior.
Tekinay, A.B., Nong, Y., Miwa, J.M., Lieberam, I., Ibanez-Tallon, I., Greengard, P. and Heintz, N.
Proceedings of the National Academy of Sciences of the United States of America 106
(11): 4477-4482.
17 March 2009
Quantifying environmental adaptation of metabolic pathways in metagenomics.
Gianoulis, T.A., Raes, J., Patel, P.V., Bjornson, R., Korbel, J.O., Letunic, I., Yamada, T., Paccanaro, A., Jensen, L.J., Snyder, M., Bork, P. and Gerstein, M.B.
Proceedings of the National Academy of Sciences of the United States of America 106
(5): 1374-1379.
3 February 2009
Distinct mechanisms act in concert to mediate cell cycle arrest.
Toettcher, J.E., Loewer, A., Ostheimer, G.J., Yaffe, M.B., Tidor, B. and Lahav, G.
Proceedings of the National Academy of Sciences of the United States of America 106
(3): 785-790.
20 January 2009
DGCR8-dependent microRNA biogenesis is essential for skin development.
Yi, R., Pasolli, H.A., Landthaler, M., Hafner, M., Ojo, T., Sheridan, R., Sander, C., O'Carroll, D., Stoffel, M., Tuschl, T. and Fuchs, E.
Proceedings of the National Academy of Sciences of the United States of America 106
(2): 498-502.
13 January 2009
2008
Identification of gene 3' ends by automated EST cluster analysis.
Muro, E.M., Herrington, R., Janmohamed, S., Frelin, C., Andrade-Navarro, M.A. and Iscove, N.N.
Proceedings of the National Academy of Sciences of the United States of America 105
(51): 20286-20290.
23 December 2008
β-catenin downregulation attenuates ischemic cardiac remodeling through enhanced resident precursor cell differentiation.
Zelarayan, L.C., Noack, C., Sekkali, B., Kmecova, J., Gehrke, C., Renger, A., Zafiriou, M.P., van der Nagel, R., Dietz, R., de Windt, L.J., Balligand, J.L. and Bergmann, M.W.
Proceedings of the National Academy of Sciences of the United States of America 105
(50): 19762-19767.
16 December 2008
ATP release through connexin hemichannels and gap junction transfer of second messengers propagate Ca2+ signals across the inner ear.
Anselmi, F., Hernandez, V.H., Crispino, G., Seydel, A., Ortolano, S., Roper, S.D., Kessaris, N., Richardson, W., Rickheit, G., Filippov, M.A., Monyer, H. and Mammano, F.
Proceedings of the National Academy of Sciences of the United States of America 105
(48): 18770-18775.
2 December 2008
Engineering antigen-specific primary human NK cells against HER-2 positive carcinomas.
Kruschinski, A., Moosmann, A., Poschke, I., Norell, H., Chmielewski, M., Seliger, B., Kiessling, R., Blankenstein, T., Abken, H. and Charo, J.
Proceedings of the National Academy of Sciences of the United States of America 105
(45): 17481-17486.
11 November 2008
Evolution of the phospho-tyrosine signaling machinery in premetazoan lineages.
Pincus, D., Letunic, I., Bork, P. and Lim, W.A.
Proceedings of the National Academy of Sciences of the United States of America 105
(28): 9680-9684.
15 July 2008
Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking.
Hellmuth, K., Grosskopf, S., Lum, C.T., Wuertele, M., Roeder, N., von Kries, J.P., Rosario, M., Rademann, J. and Birchmeier, W.
Proceedings of the National Academy of Sciences of the United States of America 105
(20): 7275-7280.
20 May 2008
Protein phosphatase 2A controls the activity of histone deacetylase 7 during T cell apoptosis and angiogenesis.
Martin, M., Potente, M., Janssens, V., Vertommen, D., Twizere, J.C., Rider, M.H., Goris, J., Dimmeler, S., Kettmann, R. and Dequiedt, F.
Proceedings of the National Academy of Sciences of the United States of America 105
(12): 4727-4732.
25 March 2008
Transposition of a reconstructed Harbinger element in human cells and functional homology with two transposon-derived cellular genes.
Sinzelle, L., Kapitonov, V.V., Grzela, D.P., Jursch, T., Jurka, J., Izsvak, Z. and Ivics, Z.
Proceedings of the National Academy of Sciences of the United States of America 105
(12): 4715-4720.
25 March 2008
Temporal compression mediated by short-term synaptic plasticity.
Leibold, C., Gundlfinger, A., Schmidt, R., Thurley, K., Schmitz, D. and Kempter, R.
Proceedings of the National Academy of Sciences of the United States of America 105
(11): 4417-4422.
18 March 2008
Requirement of protein kinase D1 for pathological cardiac remodeling.
Fielitz, J., Kim, M.S., Shelton, J.M., Qi, X., Hill, J.A., Richardson, J.A., Bassel-Duby, R. and Olson, E.N.
Proceedings of the National Academy of Sciences of the United States of America 105
(8): 3059-3063.
26 February 2008
A safeguard eliminates T cell receptor gene-modified autoreactive T cells after adoptive transfer.
Kieback, E., Charo, J., Sommermeyer, D., Blankenstein, T. and Uckert, W.
Proceedings of the National Academy of Sciences of the United States of America 105
(2): 623-628.
15 January 2008
2007
Distinct roles of Wnt/beta-catenin and Bmp signaling during early cardiogenesis.
Klaus, A., Saga, Y., Taketo, M.M., Tzahor, E. and Birchmeier, W.
Proceedings of the National Academy of Sciences of the United States of America 104
(47): 18531-18536.
20 November 2007
Distinct requirements for Gab1 in Met and EGF receptor signaling in vivo.
Schaeper, U., Vogel, R., Chmielowiec, J., Huelsken, J., Rosario, M. and Birchmeier, W.
Proceedings of the National Academy of Sciences of the United States of America 104
(39): 15376-15381.
25 September 2007
Proteasomal selection of multiprotein complexes recruited by LIM homeodomain transcription factors.
Guengoer, C., Taniguchi-Ishigaki, N., Ma, H., Drung, A., Tursun, B., Ostendorff, H.P., Bossenz, M., Becker, C.G., Becker, T. and Bach, I.
Proceedings of the National Academy of Sciences of the United States of America 104
(38): 15000-15005.
18 September 2007
Quantitative assessment of protein function prediction from metagenomics shotgun sequences.
Harrington, E.D., Singh, A.H., Doerks, T., Letunic, I., von Mering, C., Jensen, L.J., Raes, J. and Bork, P.
Proceedings of the National Academy of Sciences of the United States of America 104
(35): 13913-13918.
28 August 2007
TRPA1 mediates formalin-induced pain.
McNamara, C.R., Mandel-Brehm, J., Bautista, D.M., Siemens, J., Deranian, K.L., Zhao, M., Hayward, N.J., Chong, J.A., Julius, D., Moran, M.M. and Fanger, C.M.
Proceedings of the National Academy of Sciences of the United States of America 104
(33): 13525-13530.
14 August 2007
4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1.
Trevisani, M., Siemens, J., Materazzi, S., Bautista, D.M., Nassini, R., Campi, B., Imamachi, N., Andre, E., Patacchini, R., Cottrell, G.S., Gatti, R., Basbaum, A.I., Bunnett, N.W., Julius, D. and Geppetti, P.
Proceedings of the National Academy of Sciences of the United States of America 104
(33): 13519-13524.
14 August 2007
Cellular cofactors affecting hepatitis C virus infection and replication.
Randall, G., Panis, M., Cooper, J.D., Tellinghuisen, T.L., Sukhodolets, K.E., Pfeffer, S., Landthaler, M., Landgraf, P., Kan, S., Lindenbach, B.D., Chien, M., Weir, D.B., Russo, J.J., Ju, J., Brownstein, M.J., Sheridan, R., Sander, C., Zavolan, M., Tuschl, T. and Rice, C.M.
Proceedings of the National Academy of Sciences of the United States of America 104
(31): 12884-12889.
31 July 2007
Multimerized T cell epitopes protect from experimental autoimmune diabetes by inducing dominant tolerance.
Piaggio, E., Mars, L.T., Cassan, C., Cabarrocas, J., Hofstätter, M., Desbois, S., Bergereau, E., Roetzschke, O., Falk, K. and Liblau, R.S.
Proceedings of the National Academy of Sciences of the United States of America 104
(22): 9393-9398.
29 May 2007
Endocytosis provides a major alternative pathway for lysosomal biogenesis in kidney proximal tubular cells.
Nielsen, R., Courtoy, P.J., Jacobsen, C., Dom, G., Lima, W.R., Jadot, M., Willnow, T.E., Devuyst, O. and Christensen, E.I.
Proceedings of the National Academy of Sciences of the United States of America 104
(13): 5407-5412.
27 March 2007
Loss of muscle-specific RING-finger 3 predisposes the heart to cardiac rupture after myocardial infarction.
Fielitz, J., van Rooij, E., Spencer, J.A., Shelton, J.M., Latif, S., van der Nagel, R., Bezprozvannaya, S., de Windt, L., Richardson, J.A., Bassel-Duby, R. and Olson, E.N.
Proceedings of the National Academy of Sciences of the United States of America 104
(11): 4377-4382.
13 March 2007
RBP-J (Rbpsuh) is essential to maintain muscle progenitor cells and to generate satellite cells.
Vasyutina, E., Lenhard, D.C., Wende, H., Erdmann, B., Epstein, J.A. and Birchmeier, C.
Proceedings of the National Academy of Sciences of the United States of America 104
(11): 4443-4448.
13 March 2007
Targeted deletion of titin N2B region leads to diastolic dysfunction and cardiac atrophy.
Radke, M.H., Peng, J., Wu, Y., McNabb, M., Nelson, O.L., Granzier, H. and Gotthardt, M.
Proceedings of the National Academy of Sciences of the United States of America 104
(9): 3444-3449.
27 February 2007
The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching.
Suchting, S., Freitas, C., le Noble, F., Benedito, R., Breant, C., Duarte, A. and Eichmann, A.
Proceedings of the National Academy of Sciences of the United States of America 104
(9): 3225-3230.
27 February 2007
SOX9 is required for maintenance of the pancreatic progenitor cell pool.
Seymour, P.A., Freude, K.K., Tran, M.N., Mayes, E.E., Jensen, J., Kist, R., Scherer, G. and Sander, M.
Proceedings of the National Academy of Sciences of the United States of America 104
(6): 1865-70.
6 February 2007
2006
Continuous tooth generation in mouse is induced by activated epithelial Wnt/β-catenin signaling.
Jaervinen, E., Salazar-Ciudad, I., Birchmeier, W., Taketo, M.M., Jernvall, J. and Thesleff, I.
Proceedings of the National Academy of Sciences of the United States of America 103
(49): 18627-18632.
5 December 2006
Diversin regulates heart formation and gastrulation movements in development.
Moeller, H., Jenny, A., Schaeffer, H.J., Schwarz-Romond, T., Mlodzik, M., Hammerschmidt, M. and Birchmeier, W.
Proceedings of the National Academy of Sciences of the United States of America 103
(43): 15900-15905.
24 October 2006
Secondary lymphoid tissue chemokine (SLC/CCL21)/CCR7 signaling regulates fibrocytes in renal fibrosis.
Sakai, N., Wada, T., Yokoyama, H., Lipp, M., Ueha, S., Matsushima, K. and Kaneko, S.
Proceedings of the National Academy of Sciences of the United States of America 103
(38): 14098-14103.
19 September 2006
Lysosomal storage disease upon disruption of the neuronal chloride transport protein ClC-6.
Poet, M., Kornak, U., Schweizer, M., Zdebik, A.A., Scheel, O., Hoelter, S., Wurst, W., Schmitt, A., Fuhrmann, J.C., Planells-Cases, R., Mole, S.E., Huebner, C.A. and Jentsch, T.J.
Proceedings of the National Academy of Sciences of the United States of America 103
(37): 13854-13859.
12 September 2006
Unique self-palmitoylation activity of the transport protein particle component Bet3: A mechanism required for protein stability.
Kuemmel, D., Heinemann, U. and Veit, M.
Proceedings of the National Academy of Sciences of the United States of America 103
(34): 12701-12706.
22 August 2006
Aberrant Wnt/beta-catenin signaling can induce chromosomal instability in colon cancer.
Hadjihannas, M.V., Brueckner, M., Jerchow, B., Birchmeier, W., Dietmaier, W. and Behrens, J.
Proceedings of the National Academy of Sciences of the United States of America 103
(28): 10747-10752.
11 July 2006
Calcium-sensing receptor abrogates secretagogue- induced increases in intestinal net fluid secretion by enhancing cyclic nucleotide destruction.
Geibel, J., Sritharan, K., Geibel, R., Geibel, P., Persing, J.S., Seeger, A., Roepke, T.K., Deichstetter, M., Prinz, C., Cheng, S.X., Martin, D. and Hebert, S.C.
Proceedings of the National Academy of Sciences of the United States of America 103
(25): 9390-9397.
20 June 2006
Absence of the transcription factor CCAAT enhancer binding protein alpha results in loss of myeloid identity in bcr/abl-induced malignancy.
Wagner, K., Zhang, P., Rosenbauer, F., Drescher, B., Kobayashi, S., Radomska, H.S., Kutok, J.L., Gilliland, D.G., Krauter, J. and Tenen, D.G.
Proceedings of the National Academy of Sciences of the United States of America 103
(16): 6338-6343.
18 April 2006
Transcriptional and posttranscriptional regulation of transcription factor expression in Arabidopsis roots.
Lee, J.Y., Colinas, J., Wang, J.Y., Mace, D., Ohler, U. and Benfey, P.N.
Proceedings of the National Academy of Sciences of the United States of America 103
(15): 6055-6060.
11 April 2006
A structural role for ATP in the formation and stability of the human origin recognition complex.
Ranjan, A. and Gossen, M.
Proceedings of the National Academy of Sciences of the United States of America 103
(13): 4864-4869.
28 March 2006
Cardiac hypertrophy in transgenic rats expressing a dominant-negative mutant of the natriuretic peptide receptor B.
Langenickel, T.H., Buttgereit, J., Pagel-Langenickel, I., Lindner, M., Monti, J., Beuerlein, K., Al-Saadi, N., Plehm, R., Popova, E., Tank, J., Dietz, R., Willenbrock, R. and Bader, M.
Proceedings of the National Academy of Sciences of the United States of America 103
(12): 4735-4740.
21 March 2006
Sleeping Beauty transposase modulates cell-cycle progression through interaction with Miz-1.
Walisko, O., Izsvak, Z., Szabo, K., Kaufman, C.D., Herold, S. and Ivics, Z.
Proceedings of the National Academy of Sciences of the United States of America 103
(11): 4062-4067.
14 March 2006
Running in pregnancy transiently increases postnatal hippocampal neurogenesis in the offspring.
Bick-Sander, A., Steiner, B., Wolf, S.A., Babu, H. and Kempermann, G.
Proceedings of the National Academy of Sciences of the United States of America 103
(10): 3852-3857.
7 March 2006
Cell type specific signatures of microRNAs on target mRNA expression.
Sood, P., Krek, A., Zavolan, M., Macino, G. and Rajewsky, N.
Proceedings of the National Academy of Sciences of the United States of America 103
(8): 2746-2751.
21 February 2006
13C isotopologue perturbation studies of Listeria monocytogenes carbon metabolism and its modulation by the virulence regulator PrfA.
Eisenreich, W., Slaghuis, J., Laupitz, R., Bussemer, J., Stritzker, J., Schwarz, C., Schwarz, R., Dandekar, T., Goebel, W. and Bacher, A.
Proceedings of the National Academy of Sciences of the United States of America 103
(7): 2040-2045.
14 February 2006
Natural variation and genetic covariance in adult hippocampal neurogenesis.
Kempermann, G., Chesler, E.J., Lu, L., Williams, R.W. and Gage, F.H.
Proceedings of the National Academy of Sciences of the United States of America 103
(3): 780-785.
17 January 2006
2005
Spatial regulation of microRNA gene expression in the Drosophila embryo.
Biemar, F., Zinzen, R.P., Ronshaugen, M., Sementchenko, V., Manak, J.R. and Levine, M.S.
Proceedings of the National Academy of Sciences of the United States of America 102
(44): 15907-15911.
1 November 2005
Auditory orientation in crickets: pattern recognition controls reactive steering.
Poulet, J.F.A. and Hedwig, B.
Proceedings of the National Academy of Sciences of the United States of America 102
(43): 15665-15669.
25 October 2005
Viral targeting of the interferon-beta-inducing Traf family member-associated NF-kappaB activator (TANK)-binding kinase-1.
Unterstab, G., Ludwig, S., Anton, A., Planz, O., Dauber, B., Krappmann, D., Heins, G., Ehrhardt, C. and Wolff, T.
Proceedings of the National Academy of Sciences of the United States of America 102
(38): 13640-13645.
9 September 2005
Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.
Andersen, O.M., Reiche, J., Schmidt, V., Gotthardt, M., Spoelgen, R., Behlke, J., von Arnim, C.A.F., Breiderhoff, T., Jansen, P., Wu, X., Bales, K.R., Cappai, R., Masters, C.L., Gliemann, J., Mufson, E.J., Hyman, B.T., Paul, S.M., Nykjaer, A. and Willnow, T.E.
Proceedings of the National Academy of Sciences of the United States of America 102
(38): 13461-13466.
7 September 2005
The chaperones MPP11 and Hsp70L1 form the mammalian ribosome-associated complex.
Otto, H., Conz, C., Maier, P., Woelfle, T., Suzuki, C.K., Jenoe, P., Ruecknagel, P., Stahl, J. and Rospert, S.
Proceedings of the National Academy of Sciences of the United States of America 102
(29): 10064-10069.
19 July 2005
Recruitment of DNA methyltransferase I to DNA repair sites.
Mortusewicz, O., Schermelleh, L., Walter, J., Cardoso, M.C. and Leonhardt, H.
Proceedings of the National Academy of Sciences of the United States of America 102
(25): 8905-8909.
21 June 2005
A Mendelian locus on chromosome 16 determines susceptibility to doxorubicin nephropathy in the mouse.
Zheng, Z., Schmidt-Ott, K.M., Chua, S., Foster, K.A., Frankel, R.Z., Pavlidis, P., Barasch, J., D'Agati, V.D. and Gharavi, A.G.
Proceedings of the National Academy of Sciences of the United States of America 102
(7): 2502-2507.
15 February 2005
A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo.
Zhang, X., Smith, D.L., Meriin, A.B., Engemann, S., Russel, D.E., Roark, M., Washington, S.L., Maxwell, M.M., Marsh, J.L., Thompson, L.M., Wanker, E.E., Young, A.B., Housman, D.E., Bates, G.P., Sherman, M.Y. and Kazantsev, A.G.
Proceedings of the National Academy of Sciences of the United States of America 102
(3): 892-897.
18 January 2005
2004
Activating Met mutations produce unique tumor profiles in mice with selective duplication of the mutant allele.
Graveel, C., Su, Y., Koeman, J., Wang, L.M., Tessarollo, L., Fiscella, M., Birchmeier, C., Swiatek, P., Bronson, R. and Vande Woude, G.F.
Proceedings of the National Academy of Sciences of the United States of America 101
(49): 17198-17203.
7 December 2004
Loss of chondroitin 6-O-sulfotransferase-1 function results in severe human chondrodysplasia with progressive spinal involvement.
Thiele, H., Sakano, M., Kitagawa, H., Sugahara, K., Rajab, A., Hoehne, W., Ritter, H., Leschik, G., Nuernberg, P. and Mundlos, S.
Proceedings of the National Academy of Sciences of the United States of America 101
(27): 10155-10160.
23 June 2004
A small molecular activator of cardiac hypertrophy uncovered in a chemical screen for modifiers of the calcineurin signaling pathway.
Bush, E., Fielitz, J., Melvin, L., Martinez-Arnold, M., McKinsey, T.A., Plichta, R. and Olson, E.N.
Proceedings of the National Academy of Sciences of the United States of America 101
(9): 2870-2875.
2 March 2004
The MafA transcription factor appears to be responsible for tissue-specific expression of insulin.
Matsuoka, T., Artner, I., Henderson, E., Means, A., Sander, M. and Stein, R.
Proceedings of the National Academy of Sciences of the United States of America 101
(9): 2930-3.
2 March 2004
Met provides essential signals for liver regeneration.
Borowiak, M., Garratt, A.N., Wuestefeld, T., Strehle, M., Trautwein, C. and Birchmeier, C.
Proceedings of the National Academy of Sciences of the United States of America 101
(29): 10608-10613.
1 January 2004
2003
Adenosine gates synaptic plasticity at hippocampal mossy fiber synapses.
Moore, K.A., Nicoll, R.A. and Schmitz, D.
Proceedings of the National Academy of Sciences of the United States of America 100
(24): 14397-14402.
25 November 2003
α1E-containing Ca2+ channels are involved in synaptic plasticity.
Breustedt, J., Vogt, K.E., Miller, R.J., Nicoll, R.A. and Schmitz, D.
Proceedings of the National Academy of Sciences of the United States of America 100
(21): 12450-12455.
14 October 2003
Mutations in bone morphogenetic protein receptor 1B cause brachydactyly type A2.
Lehmann, K., Seemann, P., Stricker, S., Sammar, M., Meyer, B., Suering, K., Majewski, F., Tinschert, S., Grzeschik, K.H., Mueller, D., Knaus, P., Nuernberg, P. and Mundlos, S.
Proceedings of the National Academy of Sciences of the United States of America 100
(21): 12277-12282.
14 October 2003
Insulin regulates the activity of forkhead transcription factor Hnf-3beta/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization.
Wolfrum, C., Besser, D., Luca, E. and Stoffel, M.
Proceedings of the National Academy of Sciences of the United States of America 100
(20): 11624-11629.
30 September 2003
Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas.
Santos, R.A.S., e Silva, A.C.S., Maric, C., Silva, D.M.R., Machado, R.P., de Buhr, I., Heringer-Walther, S., Pinheiro, S.V.B., Lopes, M.T., Bader, M., Mendes, E.P., Lemos, V.S., Campagnole-Santos, M.J., Schultheiss, H.P., Speth, R. and Walther, T.
Proceedings of the National Academy of Sciences of the United States of America 100
(14): 8258-8263.
8 July 2003
Polyglutamine fibrillogenesis: The pathway unfolds.
Ross, C.A., Poirier, M.A., Wanker, E.E. and Amzel, M.
Proceedings of the National Academy of Sciences of the United States of America 100
(1): 1-3.
7 January 2003
Preferential megalin-mediated transcytosis of low-hormonogenic thyroglobulin: A control mechanism for thyroid hormone release.
Lisi, S., Pinchera, A., McCluskey, R.T., Willnow, T.E., Refetoff, S., Marcocci, C., Vitti, P., Menconi, F., Grasso, L., Luchetti, F., Collins, A.B. and Marino, M.
Proceedings of the National Academy of Sciences of the United States of America 100
(25): 14858-14863.
1 January 2003
Genome evolution reveals biochemical networks and functional modules.
von Mering, C., Zdobnov, E.M., Tsoka, S., Ciccarelli, F.D., Pereira-Leal, J.B., Ouzounis, C.A. and Bork, P.
Proceedings of the National Academy of Sciences of the United States of America 100
(26): 15428-15433.
1 January 2003
2002
A pH-sensitive histidine residue as control element for ligand release from HLA-DR molecules.
Roetzschke, O., Lau, J.M., Hofstätter, M., Falk, K. and Strominger, J.L.
Proceedings of the National Academy of Sciences of the United States of America 99
(26): 16946-16950.
24 December 2002
Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington's disease by using an automated filter retardation assay.
Heiser, V., Engemann, S., Broecker, W., Dunkel, I., Boeddrich, A., Waelter, S., Nordhoff, E., Lurz, R., Schugardt, N., Rautenberg, S., Herhaus, C., Barnickel, G., Boettcher, H., Lehrach, H. and Wanker, E.E.
Proceedings of the National Academy of Sciences of the United States of America 99
(Suppl 4): 16400-16406.
10 December 2002
The Usher syndrome proteins cadherin 23 and harmonin form a complex by means of PDZ-domain interactions.
Siemens, J., Kazmierczak, P., Reynolds, A., Sticker, M., Littlewood-Evans, A. and Mueller, U.
Proceedings of the National Academy of Sciences of the United States of America 99
(23): 14946-14951.
12 November 2002
Functional characterization and immunolocalization of the transporter encoded by the life-extending gene Indy.
Knauf, F., Rogina, B., Jiang, Z., Aronson, P.S. and Helfand, S.L.
Proceedings of the National Academy of Sciences of the United States of America 99
: 14315-14319.
29 October 2002
The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract.
Schell, M.A., Karmirantzou, M., Snel, B., Vilanova, D., Berger, B., Pessi, G., Zwahlen, M.C., Desiere, F., Bork, P., Delley, M., Pridmore, R.D. and Arigoni, F.
Proceedings of the National Academy of Sciences of the United States of America 99
(22): 14422-14427.
29 October 2002
Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy.
Özcelik, C., Erdmann, B., Pilz, B., Wettschureck, N., Britsch, S., Hübner, N., Chien, K.R., Birchmeier, C. and Garratt, A.N.
Proceedings of the National Academy of Sciences of the United States of America 99
(13): 8880-8885.
25 June 2002
Comparative genomic analysis in the region of a major Plasmodium-refractoriness locus of Anopheles gambiae.
Thomasova, D., Ton, L.Q., Copley, R.R., Zdobnov, E.M., Wang, X., Hong, Y.S., Sim, C., Bork, P., Kafatos, F.C. and Collins, F.H.
Proceedings of the National Academy of Sciences of the United States of America 99
: 8179-8184.
11 June 2002
Probabilistic clustering of sequences: inferring new bacterial regulons by comparative genomics.
van Nimwegen, E., Zavolan, M., Rajewsky, N. and Siggia, E.D.
Proceedings of the National Academy of Sciences of the United States of America 99
(11): 7323-7328.
28 May 2002
Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure.
Holtwick, R., Gotthardt, M., Skryabin, B., Steinmetz, M., Potthast, R., Zetsche, B., Hammer, R.E., Herz, J. and Kuhn, M.
Proceedings of the National Academy of Sciences of the United States of America 99
: 7142-7147.
14 May 2002
The identification of functional modules from the genomic association of genes.
Snel, B., Bork, P. and Huynen, M.A.
Proceedings of the National Academy of Sciences of the United States of America 99
: 5890-5895.
30 April 2002
Aggregation of proteins with expanded glutamine and alanine repeats of the glutamine-rich and asparagine-rich domains of Sup35 and of the amyloid β-peptide of amyloid plaques.
Perutz, M.F., Pope, B.J., Owen, D., Wanker, E.E. and Scherzinger, E.
Proceedings of the National Academy of Sciences of the United States of America 99
(8): 5596-5600.
16 April 2002
Evidence for a NOD2-independent susceptibility locus for inflammatory bowel disease on chromosome 16p.
Hampe, J., Frenzel, H., Mirza, M.M., Croucher, P.J., Cuthbert, A., Mascheretti, S., Huse, K., Platzer, M., Bridger, S., Meyer, B., Nuernberg, P., Stokkers, P., Krawczak, M., Mathew, C.G., Curran, M. and Schreiber, S.
Proceedings of the National Academy of Sciences of the United States of America 99
(1): 321-326.
8 January 2002
2001
Bazooka and atypical protein kinase C are required to regulate oocyte differentiation in the Drosophila ovary.
Cox, D.N., Seyfried, S.A., Jan, L.Y. and Jan, Y.N.
Proceedings of the National Academy of Sciences of the United States of America 98
: 14475-14480.
4 December 2001
Vaccination, prevention, and treatment of experimental autoimmune neuritis (EAN) by an oligomerized T cell epitope.
Stienekemeier, M., Falk, K., Roetzschke, O., Weishaupt, A., Schneider, C., Toyka, K.V., Gold, R. and Strominger, J.L.
Proceedings of the National Academy of Sciences of the United States of America 98
(24): 13872-13877.
1 November 2001
Myokymia and neonatal epilepsy caused by a mutation in the voltage sensor of the KCNQ2 K+ channel.
Dedek, K., Kunath, B., Kananura, C., Reuner, U., Jentsch, T.J. and Steinlein, O.K.
Proceedings of the National Academy of Sciences of the United States of America 98
(21): 12272-12277.
9 October 2001
Presynaptic kainate receptors at hippocampal mossy fiber synapses.
Schmitz, D., Mellor, J., Frerking, M. and Nicoll, R.A.
Proceedings of the National Academy of Sciences of the United States of America 98
(20): 11003-11008.
25 September 2001
When genetic distance matters: measuring genetic differentiation at microsatellite loci in whole-genome scans of recent and incipient mosquito species.
Wang, R., Zheng, L., Toure, Y.T., Dandekar, T. and Kafatos, F.C.
Proceedings of the National Academy of Sciences of the United States of America 98
(19): 10769-10774.
11 September 2001
The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia.
Fuchs, U., Rehkamp, G., Haas, O.A., Slany, R., Konig, M., Bojesen, S., Bohle, R.M., Damm-Welk, C., Ludwig, W.D., Harbott, J. and Borkhardt, A.
Proceedings of the National Academy of Sciences of the United States of America 98
(15): 8756-8761.
17 July 2001
BDNF but not NT-4 is required for normal flexion reflex plasticity and function.
Heppenstall, P.A. and Lewin, G.R.
Proceedings of the National Academy of Sciences of the United States of America 98
(14): 8107-8112.
3 July 2001
Tumor necrosis factor-related apoptosis-inducing ligand in T cell development: sensitivity of human thymocytes.
Simon, A.K., Williams, O., Mongkolsapaya, J., Jin, B., Xu, X.N., Walczak, H. and Screaton, G.R.
Proceedings of the National Academy of Sciences of the United States of America 98
(9): 5158-63.
24 April 2001
Megalin-dependent cubilin-mediated endocytosis is a major pathway for the apical uptake of transferrin in polarized epithelia.
Kozyraki, R., Fyfe, J., Verroust, P.J., Jacobsen, C., Dautry-Varsat, A., Gburek, J., Willnow, T.E., Christensen, E.I. and Moestrup, S.K.
Proceedings of the National Academy of Sciences of the United States of America 98
(22): 12491-12496.
1 January 2001
S100A1: A regulator of myocardial contractility.
Most, P., Bernotat, J., Ehlermann, P., Pleger, S.T., Reppel, M., Boerries, M., Niroomand, F., Pieske, B., Janssen, P.M.L., Eschenhagen, T., Karczewski, P., Smith, G.L., Koch, W.J.K., Katus, H.A. and Remppis, A.
Proceedings of the National Academy of Sciences of the United States of America 98
(24): 13889-13894.
1 January 2001
Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D-3.
Nykjaer, A., Fyfe, J.C., Kozyraki, R., Leheste, J.R., Jacobsen, C., Nielsen, M.S., Verroust, P.J., Aminoff, M., de la Chapelle, A., Moestrup, S.K., Ray, R., Gliemann, J., Willnow, T.E. and Christensen, E.I.
Proceedings of the National Academy of Sciences of the United States of America 98
(24): 13895-13900.
1 January 2001
Paternal relatedness and age proximity regulate social relationships among adult female rhesus macaques.
Widdig, A., Nuernberg, P., Krawczak, M., Streich, W.J. and Bercovitch, F.B.
Proceedings of the National Academy of Sciences of the United States of America 98
(24): 13769-13773.
1 January 2001
2000
Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils.
Muchowski, P.J., Schaffar, G., Sittler, A., Wanker, E.E., Hayer-Hartl, M.K. and Hartl, F.U.
Proceedings of the National Academy of Sciences of the United States of America 97
(14): 7841-7846.
5 July 2000
Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2.
Nylandsted, J., Rohde, M., Brand, K., Bastholm, L., Elling, F. and Jaattela, M.
Proceedings of the National Academy of Sciences of the United States of America 97
(14): 7871-7876.
5 July 2000
Hypoalgesia and altered inflammatory responses in mice lacking kinin B1 receptors.
Pesquero, J.B., Araujo, R.C., Heppenstall, P.A., Stucky, C.L., Silva, J.A., Walther, T., Oliveira, S.M., Pesquero, J.L., Paiva, A.C.M., Calixto, J.B., Lewin, G.R. and Bader, M.
Proceedings of the National Academy of Sciences of the United States of America 97
(14): 8140-8145.
5 July 2000
Anopheles gambiae pilot gene discovery project: Identification of mosquito innate immunity genes from expressed sequence tags generated from immune-competent cell lines.
Dimopoulos, G., Casavant, T.L., Chang, S.R., Scheetz, T., Roberts, C., Donohue, M., Schultz, J., Benes, V., Bork, P., Ansorge, W., Soares, M.B. and Kafatos, F.C.
Proceedings of the National Academy of Sciences of the United States of America 97
(12): 6619-6624.
6 June 2000
Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: implications for Huntington's disease therapy.
Heiser, V., Scherzinger, E., Boeddrich, A., Nordhoff, E., Lurz, R., Schugardt, N., Lehrach, H. and Wanker, E.E.
Proceedings of the National Academy of Sciences of the United States of America 97
(12): 6739-6744.
6 June 2000
The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription.
Steffan, J.S., Kazantsev, A., Spasic-Boskovic, O., Greenwald, M., Zhu, Y.Z., Gohler, H., Wanker, E.E., Bates, G.P., Housman, D.E. and Thompson, L.M.
Proceedings of the National Academy of Sciences of the United States of America 97
: 6763-6768.
6 June 2000
KCNQ4, a K+ channel mutated in a form of dominant deafness, is expressed in the inner ear and the central auditory pathway.
Kharkovets, T., Hardelin, J.P., Safieddine, S., Schweizer, M., El-Amraoui, A., Petit, C. and Jentsch, T.J.
Proceedings of the National Academy of Sciences of the United States of America 97
(8): 4333-4338.
11 April 2000
1999
Two-dimensional IR correlation spectroscopy: Sequential events in the unfolding process of the lamda Cro-V55C repressor protein.
Fabian, H., Mantsch, H.H. and Schultz, C.P.
Proceedings of the National Academy of Sciences of the United States of America 96
: 13153-13158.
9 November 1999
Neutral evolution of mutational robustness.
van Nimwegen, E., Crutchfield, J.P. and Huynen, M.
Proceedings of the National Academy of Sciences of the United States of America 96
: 9716-9720.
17 August 1999
Herpes simplex virus thymidine kinase/ganciclovir-induced apoptosis involves ligand-independent death receptor aggregation and activation of caspases.
Beltinger, C., Fulda, S., Kammertoens, T., Meyer, E., Uckert, W. and Debatin, K.M.
Proceedings of the National Academy of Sciences of the United States of America 96
: 8699-8704.
20 July 1999
Separation of C/EBP alpha-mediated proliferation arrest and differentiation pathways.
Mueller, C., Alunni-Fabroni, M., Kowenz-Leutz, E., Mo, X.M., Tommasino, M. and Leutz, A.
Proceedings of the National Academy of Sciences of the United States of America 96
: 7276-7281.
22 June 1999
Conformational variants of class II MHC/peptide complexes induced by N- and C-terminal extensions of minimal peptide epitopes.
Roetzschke, O., Falk, K., Mack, J., Lau, J.M., Jung, G. and Strominger, J.L.
Proceedings of the National Academy of Sciences of the United States of America 96
: 7445-7450.
22 June 1999
Unexpected abundance of self-splicing introns in the genome of bacteriophage Twort: introns in multiple genes, a single gene with three introns, and exon skipping by group I ribozymes.
Landthaler, M. and Shub, D.A.
Proceedings of the National Academy of Sciences of the United States of America 96
(12): 7005-7010.
8 June 1999
Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: implications for Huntington's disease pathology.
Scherzinger, E., Sittler, A., Schweiger, K., Heiser, V., Lurz, R., Hasenbank, R., Bates, G.P., Lehrach, H. and Wanker, E.E.
Proceedings of the National Academy of Sciences of the United States of America 96
(8): 4604-4609.
13 April 1999
Blood pressure reduction and diabetes insipidus in transgenic rats deficient in brain angiotensinogen.
Schinke, M., Baltatu, O., Boehm, M., Peters, J., Rascher, W., Bricca, G., Lippoldt, A., Ganten, D. and Bader, M.
Proceedings of the National Academy of Sciences of the United States of America 96
: 3975-3980.
30 March 1999
The Opitz syndrome gene product, MID1, associates with microtubules.
Schweiger, S., Foerster, J., Lehman, T., Suckow, V., Muller, Y.A., Walter, G., Davies, T., Porter, H., van Bokhoven, H., Lunt, P.W., Traub, P. and Ropers, H.H.
Proceedings of the National Academy of Sciences of the United States of America 96
: 2794-2799.
16 March 1999
Generation of conditional mutants in higher eukaryotes by switching between the expression of two genes.
Baron, U., Schnappinger, D., Helbl, V., Gossen, M., Hillen, W. and Bujard, H.
Proceedings of the National Academy of Sciences of the United States of America 96
: 1013-1018.
2 February 1999
1998
A pyrimidine-rich exonic splicing suppressor binds multiple RNA splicing factors and inhibits spliceosome assembly.
Zheng, Z.M., Huynen, M. and Baker, C.C.
Proceedings of the National Academy of Sciences of the United States of America 95
(24): 14088-14093.
24 November 1998
Peptide design by artificial neural networks and computer-based evolutionary search.
Schneider, G., Schrodl, W., Wallukat, G., Mueller, J., Nissen, E., Roenspeck, W., Wrede, P. and Kunze, R.
Proceedings of the National Academy of Sciences of the United States of America 95
(21): 12179-12184.
13 October 1998
Copy number control of a transposable element, the I factor, a LINE-like element in Drosophila.
Chaboissiert, M.C., Bucheton, A. and Finnegan, D.J.
Proceedings of the National Academy of Sciences of the United States of America 95
(20): 11781-11785.
29 September 1998
A novel glucose-responsive element in the human insulin gene functions uniquely in primary cultured islets.
Sander, M., Griffen, S.C., Huang, J. and German, M.S.
Proceedings of the National Academy of Sciences of the United States of America 95
(20): 11572-7.
29 September 1998
Chromosomal transposition of a Tc1/mariner-like element in mouse embryonic stem cells.
Luo, G., Ivics, Z., Izsvak, Z. and Bradley, A.
Proceedings of the National Academy of Sciences of the United States of America 95
(18): 10769-10773.
1 September 1998
Deletion of long-range regulatory elements upstream of SOX9 causes campomelic dysplasia.
Wunderle, V.M., Critcher, R., Hastie, N., Goodfellow, P.N. and Schedl, A.
Proceedings of the National Academy of Sciences of the United States of America 95
(18): 10649-10654.
1 September 1998
The Drosophila LIM-only gene, dLMO, is mutated in Beadex alleles and might represent an evolutionarily conserved function in appendage development.
Zeng, C., Justice, N.J., Abdelilah, S., Chan, Y.M., Jan, L.Y. and Jan, Y.N.
Proceedings of the National Academy of Sciences of the United States of America 95
(18): 10637-10642.
1 September 1998
ClC-5, the chloride channel mutated in Dent's disease, colocalizes with the proton pump in endocytotically active kidney cells.
Guenther, W., Luechow, A., Cluzeaud, F., Vandewalle, A. and Jentsch, T.J.
Proceedings of the National Academy of Sciences of the United States of America 95
(14): 8075-8080.
7 July 1998
Structure and function of the Bacillus hybrid enzyme GluXyn-1: Native-like jellyroll fold preserved after insertion of autonomous globular domain.
Ay, J., Goetz, F., Borriss, R. and Heinemann, U.
Proceedings of the National Academy of Sciences of the United States of America 95
(12): 6613-6618.
9 June 1998
Huntingtin aggregation monitored by dynamic light scattering.
Georgalis, Y., Starikov, E.B., Hollenbach, B., Lurz, R., Scherzinger, E., Saenger, W., Lehrach, H. and Wanker, E.E.
Proceedings of the National Academy of Sciences of the United States of America 95
(11): 6118-6121.
26 May 1998
Measuring genome evolution.
Huynen, M.A. and Bork, P.
Proceedings of the National Academy of Sciences of the United States of America 95
(11): 5849-5856.
26 May 1998
SMART, a simple modular architecture research tool: Identification of signaling domains.
Schultz, J., Milpetz, F., Bork, P. and Ponting, C.P.
Proceedings of the National Academy of Sciences of the United States of America 95
(11): 5857-5864.
26 May 1998
A substrate of the centisome 63 type III protein secretion system of Salmonella typhimurium is encoded by a cryptic bacteriophage.
Hardt, W.D., Urlaub, H. and Galan, J.E.
Proceedings of the National Academy of Sciences of the United States of America 95
(5): 2574-2579.
3 March 1998
1997
Superactivation of an immune response triggered by oligomerized T cell epitopes.
Roetzschke, O., Falk, K. and Strominger, J.L.
Proceedings of the National Academy of Sciences of the United States of America 94
(26): 14642-14647.
23 December 1997
Insulin-like growth factors-I and -II differentially regulate endogenous acetylcholine release from the rat hippocampal formation.
Kar, S., Seto, D., Dore, S., Hanisch, U. and Quirion, R.
Proceedings of the National Academy of Sciences of the United States of America 94
(25): 14054-14059.
9 December 1997
Corepressor SMRT binds the BTB/POZ repressing domain of the LAZ3/BCL6 oncoprotein.
Dhordain, P., Albagli, O., Lin, R.J., Ansieau, S., Quief, S., Leutz, A., Kerckaert, J.P., Evans, R.M. and Leprince, D.
Proceedings of the National Academy of Sciences of the United States of America 94
(20): 10762-10767.
30 September 1997
Genetic influence on neurogenesis in the dentate gyrus of adult mice.
Kempermann, G., Kuhn, H.G. and Gage, F.H.
Proceedings of the National Academy of Sciences of the United States of America 94
(19): 10409-10414.
16 September 1997
Transmembrane topology of a CLC chloride channel.
Schmidt-Rose, T. and Jentsch, T.J.
Proceedings of the National Academy of Sciences of the United States of America 94
(14): 7633-7638.
8 July 1997
Frequency-domain techniques enhance optical mammography. Initial clinical results.
Franceschini, M.A., Moesta, K.T., Fantini, S., Gaida, G., Gratton, E., Jess, H., Mantulin, W.W., Seeber, M., Schlag, P.M. and Kaschke, M.
Proceedings of the National Academy of Sciences of the United States of America 94
(12): 6468-6473.
10 June 1997
Positionally cloned human disease genes: patterns of evolutionary conservation and functional motifs.
Mushegian, A.R., Bassett, D.E., Boguski, M.S., Bork, P. and Koonin, E.V.
Proceedings of the National Academy of Sciences of the United States of America 94
: 5831-5836.
1 January 1997
1996
Intrastriatally injected c-fos antisense oligonucleotide interferes with striatonigral but not striatopallidal gamma-aminobutyric acid transmission in the conscious rat.
Sommer, W., Rimondini, R., O'Connor, W., Hansson, A., Ungerstedt, U. and Fuxe, K.
Proceedings of the National Academy of Sciences of the United States of America 93
(24): 14134-14139.
26 November 1996
Heteromultimeric CLC chloride channels with novel properties.
Lorenz, C., Pusch, M. and Jentsch, T.J.
Proceedings of the National Academy of Sciences of the United States of America 93
(23): 13362-13366.
12 November 1996
Complementation of methylation deficiency in embryonic stem cells by a DNA methyltransferase minigene.
Tucker, K.L., Talbot, D., Lee, M.A., Leonhardt, H. and Jaenisch, R.
Proceedings of the National Academy of Sciences of the United States of America 93
(23): 12920-12925.
12 November 1996
Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice.
Kistner, A., Gossen, M., Zimmermann, F., Jerecic, J., Ullmer, C., Lubbert, H. and Bujard, H.
Proceedings of the National Academy of Sciences of the United States of America 93
(20): 10933-10938.
1 October 1996
Defective forebrain development in mice lacking gp330/megalin.
Willnow, T.E., Hilpert, J., Armstrong, S.A., Rohlmann, A., Hammer, R.E., Burns, D.K. and Herz, J.
Proceedings of the National Academy of Sciences of the United States of America 93
(16): 8460-8464.
6 August 1996
Identification of functional domains and evolution of Tc1-like transposable elements.
Ivics, Z., Izsvak, Z., Minter, A. and Hackett, P.B.
Proceedings of the National Academy of Sciences of the United States of America 93
(10): 5008-5013.
14 May 1996
Induction of cellular immunity in chimpanzees to human tumor associated antigen mucin by vaccination with MUC-1 cDNA-transfected Epstein-Barr virus-immortalized autologous B cells.
Pecher, G. and Finn, O.J.
Proceedings of the National Academy of Sciences of the United States of America 93
(4): 1699-1704.
20 February 1996
DANA elements: a family of composite, tRNA-derived short interspersed DNA elements associated with mutational activities in zebrafish (Danio rerio).
Izsvak, Z., Ivics, Z., Garcia-Estefania, D., Fahrenkrug, S.C. and Hackett, P.B.
Proceedings of the National Academy of Sciences of the United States of America 93
(3): 1077-1081.
6 February 1996
1995
Efficient gene transfer into human hepatocytes by baculovirus vectors.
Hofmann, C., Sandig, V., Jennings, G., Rudolph, M., Schlag, P.M. and Strauss, M.
Proceedings of the National Academy of Sciences of the United States of America 92
(22): 10099-10103.
24 October 1995
VIP21/caveolin is a cholesterol-binding protein.
Murata, M., Peraenen, J., Schreiner, R., Wieland, F., Kurzchalia, T.V. and Simons, K.
Proceedings of the National Academy of Sciences of the United States of America 92
(22): 10339-10343.
24 October 1995
Dissection of a quantitative trait locus for genetic hypertension on rat chromosome 10.
Kreutz, R., Hübner, N., James, M.R., Bihoreau, M.T., Gauguier, D., Lathrop, G.M., Ganten, D. and Lindpaintner, K.
Proceedings of the National Academy of Sciences of the United States of America 92
(19): 8778-8782.
12 September 1995
Functional expression of low density lipoprotein receptor- related protein is controlled by receptor-associated protein in vivo.
Willnow, T.E., Armstrong, S.A., Hammer, R.E. and Herz, J.
Proceedings of the National Academy of Sciences of the United States of America 92
(10): 4537-4541.
9 May 1995
Lactation is disrupted by alpha-lactalbumin deficiency and can by restored by human alpha-lactalbumin gene replacement in mice.
Stacey, A., Schnieke, A., Kerr, M., Scott, A., McKee, C., Cottingham, I., Binas, B., Wilde, C. and Colman, A.
Proceedings of the National Academy of Sciences of the United States of America 92
(7): 2835-2839.
28 March 1995
A targeted mutation in the mouse E-cadherin gene results in defective preimplantation development.
Riethmacher, D., Brinkmann, V. and Birchmeier, C.
Proceedings of the National Academy of Sciences of the United States of America 92
(3): 855-859.
31 January 1995
Mutation of juxtamembrane tyrosine residue 1001 suppresses loss-of-function mutations of the met receptor in epithelial cells.
Weidner, K.M., Sachs, M., Riethmacher, D. and Birchmeier, W.
Proceedings of the National Academy of Sciences of the United States of America 92
: 2597-2601.
1 January 1995
1994
Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter.
Furth, P.A., Onge, S.T., Boger, H., Gruss, P., Gossen, M., Kistner, A., Bujard, H. and Hennighausen, L.
Proceedings of the National Academy of Sciences of the United States of America 91
(20): 9302-9306.
27 September 1994
Divergent T-cell cytokine patterns in inflammatory arthritis.
Simon, A.K., Seipelt, E. and Sieper, J.
Proceedings of the National Academy of Sciences of the United States of America 91
(18): 8562-6.
30 August 1994
Two highly homologous members of the ClC chloride channel family in both rat and human kidney.
Kieferle, S., Fong, P., Bens, M., Vandewalle, A. and Jentsch, T.J.
Proceedings of the National Academy of Sciences of the United States of America 91
(15): 6943-6947.
19 July 1994
Crystal structure of CspA, the major cold shock protein of Escherichia coli.
Schindelin, H., Jiang, W., Inouye, M. and Heinemann, U.
Proceedings of the National Academy of Sciences of the United States of America 91
(11): 5119-5123.
24 May 1994
Cyclin D1 expression is regulated by the retinoblastoma protein.
Mueller, H., Lukas, J., Schneider, A., Warthoe, P., Bartek, J., Eilers, M. and Strauss, M.
Proceedings of the National Academy of Sciences of the United States of America 91
(8): 2945-2949.
12 April 1994
E-cadherin gene mutations in human gastric carcinoma cell lines.
Oda, T., Kanai, Y., Oyama, T., Yoshiura, K., Shimoyama, Y., Birchmeier, W., Sugimura, T. and Hirohashi, S.
Proceedings of the National Academy of Sciences of the United States of America 91
(5): 1858-1862.
1 March 1994
Role of adrenal renin in the regulation of adrenal steroidogenesis corticotropin.
Sander, M., Ganten, D. and Mellon, S.H.
Proceedings of the National Academy of Sciences of the United States of America 91
(1): 148-152.
4 January 1994
Native-like in vivo folding of a circularly permuted jellyroll protein shown by crystal structure analysis.
Hahn, M., Piotukh, K., Borriss, R. and Heinemann, U.
Proceedings of the National Academy of Sciences of the United States of America 91
: 10417-10421.
1 January 1994
Distinct isoforms of neuregulin are expressed in mesenchymal and neuronal cells during mouse development.
Meyer, D. and Birchmeier, C.
Proceedings of the National Academy of Sciences of the United States of America 91
: 1064-1068.
1 January 1994
1993
Allele-specific peptide ligand motifs of HLA-C molecules.
Falk, K., Roetzschke, O., Grahovac, B., Schendel, D., Stevanovic, S., Gnau, V., Jung, G., Strominger, J.L. and Rammensee, H.G.
Proceedings of the National Academy of Sciences of the United States of America 90
(24): 12005-12009.
15 December 1993
Acute leukemias of different lineages have similar MLL gene fusions encoding related chimeric proteins resulting from chromosomal translocation.
Corral, J., Forster, A., Thompson, S., Lampert, F., Kaneko, Y., Slater, R., Kroes, W.G., van der Schoot, C.E., Ludwig, W.D., Karpas, A., Pocock, C., Cotter, F. and Rabitts, T.H.
Proceedings of the National Academy of Sciences of the United States of America 90
(18): 8538-8542.
15 September 1993
A familial hypertrophic cardiomyopathy locus maps to chromosome 15q2.
Thierfelder, L.H., MacRae, C., Watkins, H., Tomfohrde, J., Williams, M., McKenna, W., Bohm, K., Noeske, G., Schlepper, M. and Bowcock, A.
Proceedings of the National Academy of Sciences of the United States of America 90
(13): 6270-6274.
1 July 1993
Mechanisms of rejection induced by tumor cell-targeted gene transfer of interleukin 2, interleukin 4, interleukin 7, tumor necrosis factor, or interferon-gamma.
Hock, H., Dorsch, M., Kunzendorf, U., Qin, Z., Diamantstein, T. and Blankenstein, T.
Proceedings of the National Academy of Sciences of the United States of America 90
(7): 2774-2778.
1 April 1993
Molecular and active-site structure of a Bacillus (1-3,1-4)-beta-glucanase.
Keitel, T., Simon, O., Borriss, R. and Heinemann, U.
Proceedings of the National Academy of Sciences of the United States of America 90
: 5287-5291.
1 January 1993
1992
An ATPase domain common to prokaryotic cell cycle proteins, sugar kinases, actin, and hsp70 heat shock proteins.
Bork, P., Sander, C. and Valencia, A.
Proceedings of the National Academy of Sciences of the United States of America 89
(16): 7290-7294.
15 August 1992
Species specificity of renin kinetics in transgenic rats harboring the human renin and angiotensinogen genes.
Ganten, D., Wagner, J., Zeh, K., Bader, M., Michel, J.B., Paul, M., Zimmermann, F., Ruf, P., Hilgenfeldt, U., Ganten, U., Kaling, M., Bachmann, S., Fukamizu, A., Mullins, J.J. and Murakami, K.
Proceedings of the National Academy of Sciences of the United States of America 89
: 7806-7810.
August 1992
Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.
Gossen, M. and Bujard, H.
Proceedings of the National Academy of Sciences of the United States of America 89
(12): 5547-5551.
15 June 1992
Proposed acquisition of an animal protein domain by bacteria.
Bork, P. and Doolittle, R.F.
Proceedings of the National Academy of Sciences of the United States of America 89
: 8990-8994.
1 January 1992
A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesis.
Hartmann, G., Naldini, L., Weidner, K.M., Sachs, M., Vigna, E., Comoglio, P.M. and Birchmeier, W.
Proceedings of the National Academy of Sciences of the United States of America 89
: 11574-11578.
1 January 1992
The ankyrin repeat domains of the NF-kappa B precursor p105 and the protooncogene bcl-3 act as specific inhibitors of NF-kappaB DNA binding.
Hatada, E.N., Nieters, A., Wulczyn, F.G., Naumann, M., Meyer, R., Nucifora, G., McKeithan, T.W. and Scheidereit, C.
Proceedings of the National Academy of Sciences of the United States of America 89
(6): 2489-2493.
1 January 1992
1991
Completely functional double-barreled chloride channel expressed from a single Torpedo cDNA.
Bauer, C.K., Steinmeyer, K., Schwarz, J.R. and Jentsch, T.J.
Proceedings of the National Academy of Sciences of the United States of America 88
(24): 11052-11056.
15 December 1991
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