Browse by Journal Title

2024

Genetic determinants of micronucleus formation in vivo.
Adams, D.J. and Barlas, B. and McIntyre, R.E. and Salguero, I. and van der Weyden, L. and Barros, A. and Vicente, J.R. and Karimpour, N. and Haider, A. and Ranzani, M. and Turner, G. and Thompson, N.A. and Harle, V. and Olvera-León, R. and Robles-Espinoza, C.D. and Speak, A.O. and Geisler, N. and Weninger, W.J. and Geyer, S.H. and Hewinson, J. and Karp, N.A. and Fu, B. and Yang, F. and Kozik, Z. and Choudhary, J. and Yu, L. and van Ruiten, M.S. and Rowland, B.D. and Lelliott, C.J. and Del Castillo Velasco-Herrera, M. and Verstraten, R. and Bruckner, L. and Henssen, A.G. and Rooimans, M.A. and de Lange, J. and Mohun, T.J. and Arends, M.J. and Kentistou, K.A. and Coelho, P.A. and Zhao, Y. and Zecchini, H. and Perry, J.R.B. and Jackson, S.P. and Balmus, G.
Nature 627 (8002): 130–136. 7 March 2024

Functional and evolutionary significance of unknown genes from uncultivated taxa.
Rodríguez Del Río, Á. and Giner-Lamia, J. and Cantalapiedra, C.P. and Botas, J. and Deng, Z. and Hernández-Plaza, A. and Munar-Palmer, M. and Santamaría-Hernando, S. and Rodríguez-Herva, J.J. and Ruscheweyh, H.J. and Paoli, L. and Schmidt, T.S.B. and Sunagawa, S. and Bork, P. and López-Solanilla, E. and Coelho, L.P. and Huerta-Cepas, J.
Nature 626 (7998): 377-384. 8 February 2024

2023

Single-cell, whole-embryo phenotyping of mammalian developmental disorders.
Huang, X. and Henck, J. and Qiu, C. and Sreenivasan, V.K.A. and Balachandran, S. and Amarie, O.V. and Hrabě de Angelis, M. and Behncke, R.Y. and Chan, W.L. and Despang, A. and Dickel, D.E. and Duran, M. and Feuchtinger, A. and Fuchs, H. and Gailus-Durner, V. and Haag, N. and Hägerling, R. and Hansmeier, N. and Hennig, F. and Marshall, C. and Rajderkar, S. and Ringel, A. and Robson, M. and Saunders, L.M. and da Silva-Buttkus, P. and Spielmann, N. and Srivatsan, S.R. and Ulferts, S. and Wittler, L. and Zhu, Y. and Kalscheuer, V.M. and Ibrahim, D.M. and Kurth, I. and Kornak, U. and Visel, A. and Pennacchio, L.A. and Beier, D.R. and Trapnell, C. and Cao, J. and Shendure, J. and Spielmann, M.
Nature 623 (7988): 772-781. 23 November 2023

Latent human herpesvirus 6 is reactivated in CAR T cells.
Lareau, C.A. and Yin, Y. and Maurer, K. and Sandor, K.D. and Daniel, B. and Yagnik, G. and Peña, J. and Crawford, J.C. and Spanjaart, A.M. and Gutierrez, J.C. and Haradhvala, N.J. and Riberdy, J.M. and Abay, T. and Stickels, R.R. and Verboon, J.M. and Liu, V. and Buquicchio, F.A. and Wang, F. and Southard, J. and Song, R. and Li, W. and Shrestha, A. and Parida, L. and Getz, G. and Maus, M.V. and Li, S. and Moore, A. and Roberts, Z.J. and Ludwig, L.S. and Talleur, A.C. and Thomas, P.G. and Dehghani, H. and Pertel, T. and Kundaje, A. and Gottschalk, S. and Roth, T.L. and Kersten, M.J. and Wu, C.J. and Majzner, R.G. and Satpathy, A.T.
Nature 623 : 608-615. 16 November 2023

Inhibition of fatty acid oxidation enables heart regeneration in adult mice.
Li, X. and Wu, F. and Günther, S. and Looso, M. and Kuenne, C. and Zhang, T. and Wiesnet, M. and Klatt, S. and Zukunft, S. and Fleming, I. and Poschet, G. and Wietelmann, A. and Atzberger, A. and Potente, M. and Yuan, X. and Braun, T.
Nature 622 (7983): 619-626. 19 October 2023

Spatially resolved multiomics of human cardiac niches.
Kanemaru, K. and Cranley, J. and Muraro, D. and Miranda, A.M.A. and Ho, S.Y. and Wilbrey-Clark, A. and Patrick Pett, J. and Polanski, K. and Richardson, L. and Litvinukova, M. and Kumasaka, R. and Qin, Y. and Jablonska, Z. and Semprich, C.I. and Mach, L. and Dabrowska, M. and Richoz, R. and Bolt, L. and Mamanova, L. and Kapuge, R. and Barnett, S.N. and Perera, S. and Talavera-López, C. and Mulas, I. and Mahbubani, K.T. and Tuck, Liz and Wang, Lu and Huang, M.M. and Prete, M. and Pritchard, S. and Dark, J. and Saeb-Parsy, K. and Patel, M. and Clatworthy, M.R. and Hübner, N. and Chowdhury, R.A. and Noseda, M. and Teichmann, S.A.
Nature 619 : 801-810. 27 July 2023

Recombination between heterologous human acrocentric chromosomes.
Guarracino, A. and Buonaiuto, S. and de Lima, L.G. and Potapova, T. and Rhie, A. and Koren, S. and Rubinstein, B. and Fischer, C. and Gerton, J.L. and Phillippy, A.M. and Colonna, V. and Garrison, E.
Nature 617 (7960): 335-343. 11 May 2023

A draft human pangenome reference.
Liao, W.W. and Asri, M. and Ebler, J. and Doerr, D. and Haukness, M. and Hickey, G. and Lu, S. and Lucas, J.K. and Monlong, J. and Abel, H.J. and Buonaiuto, S. and Chang, X.H. and Cheng, H. and Chu, J. and Colonna, V. and Eizenga, J.M. and Feng, X. and Fischer, C. and Fulton, R.S. and Garg, S. and Groza, C. and Guarracino, A. and Harvey, W.T. and Heumos, S. and Howe, K. and Jain, M. and Lu, T.Y. and Markello, C. and Martin, F.J. and Mitchell, M.W. and Munson, K.M. and Mwaniki, M.N. and Novak, A.M. and Olsen, H.E. and Pesout, T. and Porubsky, D. and Prins, P. and Sibbesen, J.A. and Sirén, J. and Tomlinson, C. and Villani, F. and Vollger, M.R. and Antonacci-Fulton, L.L. and Baid, G. and Baker, C.A. and Belyaeva, A. and Billis, K. and Carroll, A. and Chang, P.C. and Cody, S. and Cook, D.E. and Cook-Deegan, R.M. and Cornejo, O.E. and Diekhans, M. and Ebert, P. and Fairley, S. and Fedrigo, O. and Felsenfeld, A.L. and Formenti, G. and Frankish, A. and Gao, Yan and Garrison, N.A. and Giron, C.G. and Green, R.E. and Haggerty, L. and Hoekzema, K. and Hourlier, T. and Ji, H.P. and Kenny, E.E. and Koenig, B.A. and Kolesnikov, A. and Korbel, J.O. and Kordosky, J. and Koren, S. and Lee, H.J. and Lewis, A.P. and Magalhães, H. and Marco-Sola, S. and Marijon, P. and McCartney, A. and McDaniel, J. and Mountcastle, J. and Nattestad, M. and Nurk, S. and Olson, N.D. and Popejoy, A.B. and Puiu, D. and Rautiainen, M. and Regier, A.A. and Rhie, A. and Sacco, S. and Sanders, A.D. and Schneider, V.A. and Schultz, B.I. and Shafin, K. and Smith, M.W. and Sofia, H.J. and Abou Tayoun, A.N. and Thibaud-Nissen, F. and Tricomi, F.F. and Wagner, J. and Walenz, B. and Wood, J.M.D. and Zimin, A.V. and Bourque, G. and Chaisson, M.J P and Flicek, Paul and Phillippy, A.M. and Zook, J.M. and Eichler, E.E. and Haussler, D. and Wang, T. and Jarvis, E.D. and Miga, K.H. and Garrison, E. and Marschall, T. and Hall, I.M. and Li, H. and Paten, B.
Nature 617 (7960): 312-324. 11 May 2023

Increased mutation and gene conversion within human segmental duplications.
Vollger, M.R. and Dishuck, P.C. and Harvey, W.T. and DeWitt, W.S. and Guitart, X. and Goldberg, M.E. and Rozanski, A.N. and Lucas, J. and Asri, M. and Munson, K.M. and Lewis, A.P. and Hoekzema, K. and Logsdon, G.A. and Porubsky, D. and Paten, B. and Harris, K. and Hsieh, P.H. and Eichler, E.E.
Nature 617 (7960): 325-334. 11 May 2023

Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA.
Abbosh, C. and Frankell, A.M. and Harrison, T. and Kisistok, J. and Garnett, A. and Johnson, L. and Veeriah, S. and Moreau, M. and Chesh, A. and Chaunzwa, T.L. and Weiss, J. and Schroeder, M.R. and Ward, S. and Grigoriadis, K. and Shahpurwalla, A. and Litchfield, K. and Puttick, C. and Biswas, D. and Karasaki, T. and Black, J.R.M. and Martínez-Ruiz, C. and Bakir, M.A.l. and Pich, O. and Watkins, T.B.K. and Lim, E.L. and Huebner, A. and Moore, D.A. and Godin-Heymann, N. and L'Hernault, A. and Bye, H. and Odell, A. and Roberts, P. and Gomes, F. and Patel, A.J. and Manzano, E. and Hiley, C.T. and Carey, N. and Riley, J. and Cook, D.E. and Hodgson, D. and Stetson, D. and Barrett, J.C. and Kortlever, R.M. and Evan, G.I. and Hackshaw, A. and Daber, R.D. and Shaw, J.A. and Aerts, H.J.W.L. and Licon, A. and Stahl, J. and Jamal-Hanjani, M. and Birkbak, N.J. and McGranahan, N. and Swanton, C.
Nature 616 (7957): 553-562. 20 April 2023

The evolution of lung cancer and impact of subclonal selection in TRACERx.
Frankell, A.M. and Dietzen, M. and Al Bakir, M. and Lim, E.L. and Karasaki, T. and Ward, S. and Veeriah, S. and Colliver, E. and Huebner, A. and Bunkum, A. and Hill, M.S. and Grigoriadis, K. and Moore, D.A. and Black, J.R.M. and Liu, W.K. and Thol, K. and Pich, O. and Watkins, T.B.K. and Naceur-Lombardelli, C. and Cook, D.E. and Salgado, R. and Wilson, G.A. and Bailey, C. and Angelova, M. and Bentham, R. and Martínez-Ruiz, C. and Abbosh, C. and Nicholson, A.G. and Le Quesne, J. and Biswas, D. and Rosenthal, R. and Puttick, C. and Hessey, S. and Lee, C. and Prymas, P. and Toncheva, A. and Smith, J. and Xing, W. and Nicod, J. and Price, G. and Kerr, K.M. and Naidu, B. and Middleton, G. and Blyth, K.G. and Fennell, D.A. and Forster, M.D. and Lee, S.M. and Falzon, M. and Hewish, M. and Shackcloth, M.J. and Lim, E. and Benafif, S. and Russell, P. and Boleti, E. and Krebs, M.G. and Lester, J.F. and Papadatos-Pastos, D. and Ahmad, T. and Thakrar, R.M. and Lawrence, D. and Navani, N. and Janes, S.M. and Dive, C. and Blackhall, F.H and Summers, Y. and Cave, J. and Marafioti, T. and Herrero, J. and Quezada, S.A. and Peggs, K.S. and Schwarz, R.F. and Van Loo, P. and Miedema, D.M. and Birkbak, N.J. and Hiley, C.T. and Hackshaw, A. and Zaccaria, S. and Jamal-Hanjani, M. and McGranahan, N. and Swanton, C.
Nature 616 (7957): 525-533. 20 April 2023

The little skate genome and the evolutionary emergence of wing-like fins.
Marlétaz, F. and de la Calle-Mustienes, E. and Acemel, R.D. and Paliou, C. and Naranjo, S. and Martínez-García, P.M. and Cases, I. and Sleight, V.A. and Hirschberger, C. and Marcet-Houben, M. and Navon, D. and Andrescavage, A. and Skvortsova, K. and Duckett, P.Ed. and González-Rajal, Á. and Bogdanovic, O. and Gibcus, J.H. and Yang, L. and Gallardo-Fuentes, L. and Sospedra, I. and Lopez-Rios, J. and Darbellay, F. and Visel, A. and Dekker, J. and Shubin, N. and Gabaldón, T. and Nakamura, T. and Tena, J.J. and Lupianez, D.G. and Rokhsar, D.S. and Gómez-Skarmeta, J.L.
Nature 616 (7957): 495-503. 20 April 2023

Genomic–transcriptomic evolution in lung cancer and metastasis.
Martínez-Ruiz, C. and Black, J.R.M. and Puttick, C. and Hill, M.S. and Demeulemeester, J. and Larose Cadieux, E. and Thol, K. and Jones, T.P. and Veeriah, S. and Naceur-Lombardelli, C. and Toncheva, A. and Prymas, P. and Rowan, A. and Ward, S. and Cubitt, L. and Athanasopoulou, F. and Pich, O. and Karasaki, T. and Moore, D.A. and Salgado, R. and Colliver, E. and Castignani, C. and Dietzen, M. and Huebner, A. and Al Bakir, M. and Tanić, M. and Watkins, T.B.K. and Lim, E.L. and Al-Rashed, A.M. and Lang, D. and Clements, J. and Cook, D.E. and Rosenthal, R. and Wilson, G. A. and Frankell, A.M. and de Carné Trécesson, S. and East, P. and Kanu, N. and Litchfield, K. and Birkbak, N.J. and Hackshaw, A. and Beck, S. and Van Loo, P. and Jamal-Hanjani, M. and McGranahan, N. and Swanton, C.
Nature 616 (7957): 543-552. 20 April 2023

Antibodies against endogenous retroviruses promote lung cancer immunotherapy.
Ng, K.W. and Boumelha, J. and Enfield, K.S.S. and Almagro, J. and Cha, H. and Pich, O. and Karasaki, T. and Moore, D.A. and Salgado, R. and Sivakumar, M. and Young, G. and Molina-Arcas, M. and de Carné Trécesson, S. and Anastasiou, P. and Fendler, A. and Au, L. and Shepherd, S.T.C. and Martínez-Ruiz, C. and Puttick, C. and Black, J.R.M. and Watkins, T.B.K. and Kim, H. and Shim, S. and Faulkner, N. and Attig, J. and Veeriah, S. and Magno, N. and Ward, S. and Frankell, A.M. and Al Bakir, M. and Lim, E.L. and Hill, M.S. and Wilson, G.A. and Cook, D.E. and Birkbak, N.J. and Behrens, A. and Yousaf, N. and Popat, S. and Hackshaw, A. and Hiley, C.T. and Litchfield, K. and McGranahan, N. and Jamal-Hanjani, M. and Larkin, J. and Lee, S.H. and Turajlic, S. and Swanton, C. and Downward, J. and Kassiotis, G.
Nature 616 (7957): 563-573. 20 April 2023

Lung adenocarcinoma promotion by air pollutants.
Hill, W. and Lim, E.L. and Weeden, C.E. and Lee, C. and Augustine, M. and Chen, K. and Kuan, F.C. and Marongiu, F. and Evans, E.J. and Moore, D.A. and Rodrigues, F.S. and Pich, O. and Bakker, B. and Cha, H. and Myers, R. and van Maldegem, F. and Boumelha, J. and Veeriah, S. and Rowan, A. and Naceur-Lombardelli, C. and Karasaki, T. and Sivakumar, M. and De, S. and Caswell, D.R. and Nagano, A. and Black, J.R.M. and Martínez-Ruiz, C. and Ryu, M.H. and Huff, R.D. and Li, S. and Favé, M.J. and Magness, A. and Suárez-Bonnet, A. and Priestnall, S.L. and Lüchtenborg, M. and Lavelle, K. and Pethick, J. and Hardy, S. and McRonald, F.E. and Lin, M.H. and Troccoli, C.I. and Ghosh, M. and Miller, Y.E. and Merrick, D.T. and Keith, R.L. and Al Bakir, M. and Bailey, C. and Hill, M.S. and Saal, L.H. and Chen, Y. and George, A.M. and Abbosh, C. and Kanu, N. and Lee, S.H. and McGranahan, N. and Berg, C.D. and Sasieni, P. and Houlston, R. and Turnbull, C. and Lam, S. and Awadalla, P. and Grönroos, E. and Downward, J. and Jacks, T. and Carlsten, C. and Malanchi, I. and Hackshaw, A. and Litchfield, K. and DeGregori, J. and Jamal-Hanjani, M. and Swanton, C.
Nature 616 (7955): 159-167. 6 April 2023

The evolution of non-small cell lung cancer metastases in TRACERx.
Al Bakir, M. and Huebner, A. and Martínez-Ruiz, C. and Grigoriadis, K. and Watkins, T.B.K. and Pich, O. and Moore, D.A. and Veeriah, S. and Ward, S. and Laycock, J. and Johnson, D. and Rowan, A. and Razaq, M. and Akther, M. and Naceur-Lombardelli, C. and Prymas, P. and Toncheva, A. and Hessey, S. and Dietzen, M. and Colliver, E. and Frankell, A.M. and Bunkum, A. and Lim, E.L. and Karasaki, T. and Abbosh, C. and Hiley, C.T. and Hill, M.S. and Cook, D.E. and Wilson, G.A. and Salgado, R. and Nye, E. and Stone, R.K. and Fennell, D.A. and Price, G. and Kerr, K.M. and Naidu, B. and Middleton, G. and Summers, Y. and Lindsay, C.R. and Blackhall, F.H. and Cave, J. and Blyth, K.G. and Nair, A. and Ahmed, A. and Taylor, M.N. and Procter, A.J. and Falzon, M. and Lawrence, D. and Navani, N. and Thakrar, R.M. and Janes, S.M. and Papadatos-Pastos, D. and Forster, M.D. and Lee, S.M. and Ahmad, T. and Quezada, S.A. and Peggs, K.S. and Van Loo, P. and Dive, C. and Hackshaw, A. and Birkbak, N.J. and Zaccaria, S. and Jamal-Hanjani, M. and McGranahan, N. and Swanton, C.
Nature 616 (7957): 534-542. April 2023

The cellular coding of temperature in the mammalian cortex.
Vestergaard, M. and Carta, M. and Güney, G. and Poulet, J.F.A.
Nature 614 (7949): 725-731. 23 February 2023

The brain's encoding of warm and cool.
Vestergaard, M. and Poulet, J.
Nature 8 February 2023 (In Press)

Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studies.
Kennedy, K.M. and de Goffau, M.C. and Perez-Muñoz, M.E. and Arrieta, M.C. and Bäckhed, F. and Bork, P. and Braun, T. and Bushman, F.D. and Dore, J. and de Vos, W.M. and Earl, A.M. and Eisen, J.A. and Elovitz, M.A. and Ganal-Vonarburg, S.C. and Gänzle, M.G. and Garrett, W.S. and Hall, L.J. and Hornef, M.W. and Huttenhower, C. and Konnikova, L. and Lebeer, S. and Macpherson, A.J. and Massey, R.C. and McHardy, A.C. and Koren, O. and Lawley, T.D. and Ley, R.E. and O'Mahony, L. and O'Toole, P.W. and Pamer, E.G. and Parkhill, J. and Raes, J. and Rattei, T. and Salonen, A. and Segal, E. and Segata, N. and Shanahan, F. and Sloboda, D.M. and Smith, G.C.S. and Sokol, H. and Spector, T.D. and Surette, M.G. and Tannock, G.W. and Walker, A.W. and Yassour, M. and Walter, J.
Nature 613 (7945): 639-649. 26 January 2023

2022

Non-redundant functions of group 2 innate lymphoid cells.
Jarick, K.J. and Topczewska, P.M. and Jakob, M.O. and Yano, H. and Arifuzzaman, M. and Gao, X. and Boulekou, S. and Stokic-Trtica, V. and Leclère, P.S. and Preußer, A. and Rompe, Z.A. and Stamm, A. and Tsou, A.M. and Chu, C. and Heinrich, F.R. and Guerra, G.M. and Durek, P. and Ivanov, A. and Beule, D. and Helfrich, S. and Duerr, C.U. and Kühl, A.A. and Stehle, C. and Romagnani, C. and Mashreghi, M.F. and Diefenbach, A. and Artis, D. and Klose, C.S.N.
Nature 611 (7937): 794-800. 24 November 2022

Identification of environmental factors that promote intestinal inflammation.
Sanmarco, L.M. and Chao, C.C. and Wang, Y.C. and Kenison, J.E. and Li, Z. and Rone, J.M. and Rejano-Gordillo, C.M. and Polonio, C.M. and Gutierrez-Vazquez, C. and Piester, G. and Plasencia, A. and Li, L. and Giovannoni, F. and Lee, H.G. and Faust Akl, C. and Wheeler, M.A. and Mascanfroni, I. and Jaronen, M. and Alsuwailm, M. and Hewson, P. and Yeste, A. and Andersen, B.M. and Franks, D.G. and Huang, C.J. and Ekwudo, M. and Tjon, E.C. and Rothhammer, V. and Takenaka, M. and de Lima, K.A. and Linnerbauer, M. and Guo, L. and Covacu, R. and Queva, H. and Fonseca-Castro, P.H. and Bladi, M.A. and Cox, L.M. and Hodgetts, K.J. and Hahn, M.E. and Mildner, A. and Korzenik, J. and Hauser, R. and Snapper, S.B. and Quintana, F.J.
Nature 611 (7937): 801-809. 24 November 2022

Semi-automated assembly of high-quality diploid human reference genomes.
Jarvis, E.D. and Formenti, G. and Rhie, A. and Guarracino, A. and Yang, C. and Wood, J. and Tracey, A. and Thibaud-Nissen, F. and Vollger, M.R. and Porubsky, D. and Cheng, H. and Asri, M. and Logsdon, G.A. and Carnevali, P. and Chaisson, M.J.P. and Chin, C.S. and Cody, S. and Collins, J. and Ebert, P. and Escalona, M. and Fedrigo, O. and Fulton, R.S. and Fulton, L.L. and Garg, S. and Gerton, J.L. and Ghurye, J. and Granat, A. and Green, R.E. and Harvey, W. and Hasenfeld, P. and Hastie, A. and Haukness, M. and Jaeger, E.B. and Jain, M. and Kirsche, M. and Kolmogorov, M. and Korbel, J.O. and Koren, S. and Korlach, J. and Lee, J. and Li, D. and Lindsay, T. and Lucas, J. and Luo, F. and Marschall, T. and Mitchell, M.W. and McDaniel, J. and Nie, F. and Olsen, H.E. and Olson, N.D. and Pesout, T. and Potapova, T. and Puiu, D. and Regier, A. and Ruan, J. and Salzberg, S.L. and Sanders, A.D. and Schatz, M.C. and Schmitt, A. and Schneider, V.A. and Selvaraj, S. and Shafin, K. and Shumate, A. and Stitziel, N.O. and Stober, C. and Torrance, J. and Wagner, J. and Wang, J. and Wenger, A. and Xiao, C. and Zimin, A.V. and Zhang, G. and Wang, T. and Li, H. and Garrison, E. and Haussler, D. and Hall, I. and Zook, J.M. and Eichler, E.E. and Phillippy, A.M. and Paten, B. and Howe, K. and Miga, K.H.
Nature 611 (7936): 519-531. 17 November 2022

Biosynthetic potential of the global ocean microbiome.
Paoli, L. and Ruscheweyh, H.J. and Forneris, C.C. and Hubrich, F. and Kautsar, S. and Bhushan, A. and Lotti, A. and Clayssen, Q. and Salazar, G. and Milanese, A. and Carlström, C.I. and Papadopoulou, C. and Gehrig, D. and Karasikov, M. and Mustafa, H. and Larralde, M. and Carroll, L.M. and Sánchez, P. and Zayed, A.A. and Cronin, D.R. and Acinas, S.G. and Bork, P. and Bowler, C. and Delmont, T.O. and Gasol, J.M. and Gossert, A.D. and Kahles, A. and Sullivan, M.B. and Wincker, P. and Zeller, G. and Robinson, S.L. and Piel, J. and Sunagawa, S.
Nature 607 (7917): 111-118. 7 July 2022

Towards the biogeography of prokaryotic genes.
Coelho, L.P. and Alves, R. and Del Río, Á.R. and Myers, P.N. and Cantalapiedra, C.P. and Giner-Lamia, J. and Schmidt, T.S. and Mende, D.R. and Orakov, A. and Letunic, I. and Hildebrand, F. and Van Rossum, T. and Forslund, S.K. and Khedkar, S. and Maistrenko, O.M. and Pan, S. and Jia, L. and Ferretti, P. and Sunagawa, S. and Zhao, X.M. and Nielsen, H.B. and Huerta-Cepas, J. and Bork, P.
Nature 601 (7892): 252-256. 13 January 2022

2021

ecDNA hubs drive cooperative intermolecular oncogene expression.
Hung, K.L. and Yost, K.E. and Xie, L. and Shi, Q. and Helmsauer, K. and Luebeck, J. and Schöpflin, R. and Lange, J.T. and Chamorro González, R. and Weiser, N.E. and Chen, C. and Valieva, M.E. and Wong, I.T.L. and Wu, S. and Dehkordi, S.R. and Duffy, C.V. and Kraft, K. and Tang, J. and Belk, J.A. and Rose, J.C. and Corces, M.R. and Granja, J.M. and Li, R. and Rajkumar, U. and Friedlein, J. and Bagchi, A. and Satpathy, A.T. and Tjian, R. and Mundlos, S. and Bafna, V. and Henssen, A.G. and Mischel, P.S. and Liu, Z. and Chang, H.Y.
Nature 600 (7890): 731-736. 23 December 2021

Combinatorial, additive and dose-dependent drug-microbiome associations.
Forslund, S.K. and Chakaroun, R. and Zimmermann-Kogadeeva, M. and Markó, L. and Aron-Wisnewsky, J. and Nielsen, T. and Moitinho-Silva, L. and Schmidt, T.S.B. and Falony, G. and Vieira-Silva, S. and Adriouch, S. and Alves, R.J. and Assmann, K. and Bastard, J.P. and Birkner, T. and Caesar, R. and Chilloux, J. and Coelho, L.P. and Fezeu, L. and Galleron, N. and Helft, G. and Isnard, R. and Ji, B. and Kuhn, M. and Le Chatelier, E. and Myridakis, A. and Olsson, L. and Pons, N. and Prifti, E. and Quinquis, B. and Roume, H. and Salem, J.E. and Sokolovska, N. and Tremaroli, V. and Valles-Colomer, M. and Lewinter, C. and Søndertoft, N.B. and Pedersen, H.K. and Hansen, T.H. and Gøtze, J.P. and Køber, L. and Vestergaard, H. and Hansen, T. and Zucker, J.D. and Hercberg, S. and Oppert, J.M. and Letunic, I. and Nielsen, J. and Bäckhed, F. and Ehrlich, S.D. and Dumas, M.E. and Raes, J. and Pedersen, O. and Clément, K. and Stumvoll, M. and Bork, P.
Nature 600 : 500-505. 16 December 2021

Mapping the human genetic architecture of COVID-19.

Nature 600 (7889): 472-477. December 2021

Cell-type specialization is encoded by specific chromatin topologies.
Winick-Ng, W. and Kukalev, A. and Harabula, I. and Zea-Redondo, L. and Szabó, D. and Meijer, M. and Serebreni, L. and Zhang, Y. and Bianco, S. and Chiariello, A.M. and Irastorza-Azcarate, I. and Thieme, C.J. and Sparks, T.M. and Carvalho, S. and Fiorillo, L. and Musella, F. and Irani, E. and Triglia, E.T. and Kolodziejczyk, A.A. and Abentung, A. and Apostolova, G. and Paul, E.J. and Franke, V. and Kempfer, R. and Akalin, A. and Teichmann, S.A. and Dechant, G. and Ungless, M.A. and Nicodemi, M. and Welch, L. and Castelo-Branco, G. and Pombo, A.
Nature 599 (7886): 684-691. 25 November 2021

Virus-induced senescence is driver and therapeutic target in COVID-19.
Lee, S. and Yu, Y. and Trimpert, J. and Benthani, F. and Mairhofer, M. and Richter-Pechanska, P. and Wyler, E. and Belenki, D. and Kaltenbrunner, S. and Pammer, M. and Kausche, L. and Firsching, T.C. and Dietert, K. and Schotsaert, M. and Martínez-Romero, C. and Singh, G. and Kunz, S. and Niemeyer, D. and Ghanem, R. and Salzer, H.J.F. and Paar, C. and Mülleder, M. and Uccellini, M. and Michaelis, E.G. and Khan, A. and Lau, A. and Schönlein, M. and Habringer, A. and Tomasits, J. and Adler, J.M. and Kimeswenger, S. and Gruber, A.D. and Hoetzenecker, W. and Steinkellner, H. and Purfuerst, B. and Motz, R. and Di Pierro, F. and Lamprecht, B. and Osterrieder, N. and Landthaler, M. and Drosten, C. and García-Sastre, A. and Langer, R. and Ralser, M. and Eils, R. and Reimann, M. and Fan, D.N.Y. and Schmitt, C.A.
Nature 599 : 283-289. 11 November 2021

Unravelling the collateral damage of antibiotics on gut bacteria.
Maier, L. and Goemans, C.V. and Wirbel, J. and Kuhn, M. and Eberl, C. and Pruteanu, M. and Müller, P. and Garcia-Santamarina, S. and Cacace, E. and Zhang, B. and Gekeler, C. and Banerjee, T. and Anderson, E.E. and Milanese, A. and Löber, U. and Forslund, S.K. and Patil, K.R. and Zimmermann, M. and Stecher, B. and Zeller, G. and Bork, P. and Typas, A.
Nature 599 : 120-124. 4 November 2021

Using DNA sequencing data to quantify T cell fraction and therapy response.
Bentham, R. and Litchfield, K. and Watkins, T.B.K. and Lim, E.L. and Rosenthal, R. and Martínez-Ruiz, C. and Hiley, C.T. and Bakir, M.A. and Salgado, R. and Moore, D.A. and Jamal-Hanjani, M. and Swanton, C. and McGranahan, N.
Nature 597 (7877): 555-560. 23 September 2021

Bioaccumulation of therapeutic drugs by human gut bacteria.
Klünemann, M. and Andrejev, S. and Blasche, S. and Mateus, A. and Phapale, P. and Devendran, S. and Vappiani, J. and Simon, B. and Scott, T.A. and Kafkia, E. and Konstantinidis, D. and Zirngibl, K. and Mastrorilli, E. and Banzhaf, M. and Mackmull, M.T. and Hövelmann, F. and Nesme, L. and Brochado, A.R. and Maier, L. and Bock, T. and Periwal, V. and Kumar, M. and Kim, Y. and Tramontano, M. and Schultz, C. and Beck, M. and Hennig, J. and Zimmermann, M. and Sévin, D.C. and Cabreiro, F. and Savitski, M.M. and Bork, P. and Typas, A. and Patil, K.R.
Nature 597 : 533-538. 23 September 2021

Quantitative lineage analysis identifies a hepato-pancreato-biliary progenitor niche.
Willnow, D. and Benary, U. and Margineanu, A. and Vignola, M.L. and Konrath, F. and Pongrac, I.M. and Karimaddini, Z. and Vigilante, A. and Wolf, J. and Spagnoli, F.M.
Nature 597 (7874): 87-91. 2 September 2021

Interpreting type 1 diabetes risk with genetics and single-cell epigenomics.
Chiou, J. and Geusz, R.J. and Okino, M.L. and Han, J.Y. and Miller, M. and Melton, R. and Beebe, E. and Benaglio, P. and Huang, S. and Korgaonkar, K. and Heller, S. and Kleger, A. and Preissl, S. and Gorkin, D.U. and Sander, M. and Gaulton, K.J.
Nature 594 (7863): 398-402. 17 June 2021

PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism.
Ren, A.A. and Snellings, D.A. and Su, Y.S. and Hong, C.C. and Castro, M. and Tang, A.T. and Detter, M.R. and Hobson, N. and Girard, R. and Romanos, S. and Lightle, R. and Moore, T. and Shenkar, R. and Benavides, C. and Beaman, M.M. and Mueller-Fielitz, H. and Chen, M. and Mericko, P. and Yang, J. and Sung, D.C. and Lawton, M.T. and Ruppert, M. and Schwaninger, M. and Körbelin, J. and Potente, M. and Awad, I.A. and Marchuk, D.A. and Kahn, M.L.
Nature 594 (7862): :271-276. 10 June 2021

Swarm Learning for decentralized and confidential clinical machine learning.
Warnat-Herresthal, S. and Schultze, H. and Shastry, K.L. and Manamohan, S. and Mukherjee, S. and Garg, V. and Sarveswara, R. and Händler, K. and Pickkers, P. and Aziz, N.A. and Ktena, S. and Tran, F. and Bitzer, M. and Ossowski, S. and Casadei, N. and Herr, C. and Petersheim, D. and Behrends, U. and Kern, F. and Fehlmann, T. and Schommers, P. and Lehmann, C. and Augustin, M. and Rybniker, J. and Altmüller, J. and Mishra, N. and Bernardes, J.P. and Krämer, B. and Bonaguro, L. and Schulte-Schrepping, J. and De Domenico, E. and Siever, C. and Kraut, M. and Desai, M. and Monnet, B. and Saridaki, M. and Siegel, C.M. and Drews, A. and Nuesch-Germano, M. and Theis, H. and Heyckendorf, J. and Schreiber, S. and Kim-Hellmuth, S. and Nattermann, J. and Skowasch, D. and Kurth, I. and Keller, A. and Bals, R. and Nürnberg, P. and Rieß, O. and Rosenstiel, P. and Netea, M.G. and Theis, F. and Mukherjee, S. and Backes, M. and Aschenbrenner, A.C. and Ulas, T. and Breteler, M.M.B. and Giamarellos-Bourboulis, E.J. and Kox, M. and Becker, M. and Cheran, S. and Woodacre, M.S. and Goh, E.L. and Schultze, J.L.
Nature 594 (7862): 265-270. 10 June 2021

Non-coding deletions identify Maenli lncRNA as a limb-specific En1 regulator.
Allou, L. and Balzano, S. and Magg, A. and Quinodoz, M. and Royer-Bertrand, B. and Schöpflin, R. and Chan, W.L. and Speck-Martins, C.E. and Carvalho, D.R. and Farage, L. and Lourenço, C.M. and Albuquerque, R. and Rajagopal, S. and Nampoothiri, S. and Campos-Xavier, B. and Chiesa, C. and Niel-Bütschi, F. and Wittler, L. and Timmermann, B. and Spielmann, M. and Robson, M.I. and Ringel, A. and Heinrich, V. and Cova, G. and Andrey, G. and Prada-Medina, C.A. and Pescini-Gobert, R. and Unger, S. and Bonafé, L. and Grote, P. and Rivolta, C. and Mundlos, S. and Superti-Furga, A.
Nature 592 (7852): 93-98. 1 April 2021

Skin-resident innate lymphoid cells converge on a pathogenic effector state.
Bielecki, P. and Riesenfeld, S.J. and Hütter, J.C. and Torlai Triglia, E. and Kowalczyk, M.S. and Ricardo-Gonzalez, R.R. and Lian, M. and Amezcua Vesely, M.C. and Kroehling, L. and Xu, H. and Slyper, M. and Muus, C. and Ludwig, L.S. and Christian, E. and Tao, L. and Kedaigle, A.J. and Steach, H.R. and York, A.G. and Skadow, M.H. and Yaghoubi, P. and Dionne, D. and Jarret, A. and McGee, H.M. and Porter, C.B.M. and Licona-Limón, P. and Bailis, W. and Jackson, R. and Gagliani, N. and Gasteiger, G. and Locksley, R.M. and Regev, A. and Flavell, R.A.
Nature 592 (7852): 128-132. 1 April 2021

Systematic analysis of binding of transcription factors to noncoding variants.
Yan, J. and Qiu, Y. and Ribeiro Dos Santos, A.M. and Yin, Y. and Li, Y.E. and Vinckier, N. and Nariai, N. and Benaglio, P. and Raman, A. and Li, X. and Fan, S. and Chiou, J. and Chen, F. and Frazer, K.A. and Gaulton, K.J. and Sander, M. and Taipale, Ju. and Ren, B.
Nature 591 (7848): 147-151. March 2021

Arterialization requires the timely suppression of cell growth.
Luo, W. and Garcia-Gonzalez, I. and Fernández-Chacón, M. and Casquero-Garcia, V. and Sanchez-Muñoz, M.S. and Mühleder, S. and Garcia-Ortega, L. and Andrade, J. and Potente, M. and Benedito, R.
Nature 589 (7842): 437-441. 21 January 2021

2020

Cells of the adult human heart.
Litviňuková, M. and Talavera-López, C. and Maatz, H. and Reichart, D. and Worth, C.L. and Lindberg, E.L. and Kanda, M. and Polanski, K. and Heinig, M. and Lee, M.l and Nadelmann, E.R. and Roberts, K. and Tuck, L. and Fasouli, E.S. and DeLaughter, D.M. and McDonough, B. and Wakimoto, H. and Gorham, J.M. and Samari, S. and Mahbubani, K.T. and Saeb-Parsy, K. and Patone, G. and Boyle, J.J. and Zhang, H. and Zhang, H. and Viveiros, A. and Oudit, G.Y. and Bayraktar, O. and Seidman, J.G. and Seidman, C.E. and Noseda, M. and Hubner, N. and Teichmann, S.A.
Nature 588 (7838): 466-472. 17 December 2020

Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms.
Jayavelu, A.K. and Schnöder, T.M. and Perner, F. and Herzog, C. and Meiler, A. and Krishnamoorthy, G. and Huber, N. and Mohr, J. and Edelmann-Stephan, B. and Austin, R. and Brandt, S. and Palandri, F. and Schröder, N. and Isermann, B. and Edlich, F. and Sinha, A.U. and Ungelenk, M. and Hübner, C.A. and Zeiser, R. and Rahmig, S. and Waskow, C. and Coldham, I. and Ernst, T. and Hochhaus, A. and Jilg, S. and Jost, P.J. and Mullally, A. and Bullinger, L. and Mertens, P.R. and Lane, S.W. and Mann, M. and Heidel, F.H.
Nature 588 (7836): 157-163. 3 December 2020

LifeTime and improving European healthcare through cell-based interceptive medicine.
Rajewsky, N. and Almouzni, G. and Gorski, S.A. and Aerts, S. and Amit, I. and Bertero, M.G. and Bock, C. and Bredenoord, A.L. and Cavalli, G. and Chiocca, S. and Clevers, H. and De Strooper, B. and Eggert, A. and Ellenberg, J. and Fernández, X.M. and Figlerowicz, M. and Gasser, S.M. and Hubner, N. and Kjems, J. and Knoblich, J.A. and Krabbe, G. and Lichter, P. and Linnarsson, S. and Marine, J.C. and Marioni, J. and Marti-Renom, M.A. and Netea, M.G. and Nickel, D. and Nollmann, M. and Novak, H.R. and Parkinson, H. and Piccolo, S. and Pinheiro, I. and Pombo, A. and Popp, C. and Reik, W. and Roman-Roman, S. and Rosenstiel, P. and Schultze, J.L. and Stegle, O. and Tanay, A. and Testa, G. and Thanos, D. and Theis, F.J. and Torres-Padilla, M.E. and Valencia, A. and Vallot, C. and van Oudenaarden, A. and Vidal, M. and Voet, T.
Nature 587 (7834): 377-386. 19 November 2020

Pervasive chromosomal instability and karyotype order in tumour evolution.
Watkins, T.B.K. and Lim, E.L. and Petkovic, M. and Elizalde, S. and Birkbak, N.J. and Wilson, G.A. and Moore, D.A. and Grönroos, E. and Rowan, A. and Dewhurst, S.M. and Demeulemeester, J. and Dentro, S.C. and Horswell, S. and Au, L. and Haase, K. and Escudero, M. and Rosenthal, R. and Bakir, M.A. and Xu, H. and Litchfield, K. and Lu, W.T. and Mourikis, T.P. and Dietzen, M. and Spain, L. and Cresswell, G.D. and Biswas, D. and Lamy, P. and Nordentoft, I. and Harbst, K. and Castro-Giner, F. and Yates, L.R. and Caramia, F. and Jaulin, F. and Vicier, C. and Tomlinson, I.P.M. and Brastianos, P.K. and Cho, R.J. and Bastian, B.C. and Dyrskjøt, L. and Jönsson, G.B. and Savas, P. and Loi, S. and Campbell, P.J. and Andre, F. and Luscombe, N.M. and Steeghs, N. and Tjan-Heijnen, V.C.G. and Szallasi, Z. and Turajlic, S. and Jamal-Hanjani, M. and Van Loo, P. and Bakhoum, S.F. and Schwarz, R.F. and McGranahan, N. and Swanton, C.
Nature 587 (7832): 126-132. 5 November 2020

Rescue of oxytocin response and social behaviour in a mouse model of autism.
Hörnberg, H. and Pérez-Garci, E. and Schreiner, D. and Hatstatt-Burklé, L. and Magara, F. and Baudouin, S. and Matter, A. and Nacro, K. and Pecho-Vrieseling, E. and Scheiffele, P.
Nature 584 (7820): 252-256. 13 August 2020

Epigenetic regulator function through mouse gastrulation.
Grosswendt, S. and Kretzmer, H. and Smith, Z.D. and Kumar, A.S. and Hetzel, S. and Wittler, L. and Klages, S. and Timmermann, B. and Mukherji, S. and Meissner, A.
Nature 584 (7819): 102-108. 6 August 2020

Statin therapy is associated with lower prevalence of gut microbiota dysbiosis.
Vieira-Silva, S. and Falony, G. and Belda, E. and Nielsen, T. and Aron-Wisnewsky, J. and Chakaroun, R. and Forslund, S.K. and Assmann, K. and Valles-Colomer, M. and Nguyen, T..D. and Proost, S. and Prifti, E. and Tremaroli, V. and Pons, N. and Le Chatelier, E. and Andreelli, F. and Bastard, J.P. and Coelho, L.P. and Galleron, N. and Hansen, T.H. and Hulot, J.S. and Lewinter, C. and Pedersen, H.K. and Quinquis, B. and Rouault, C. and Roume, H. and Salem, J.E. and Søndertoft, N.B. and Touch, S. and Dumas, M.E. and Ehrlich, S.D. and Galan, P. and Gøtze, J.P. and Hansen, T. and Holst, J.J. and Køber, L. and Letunic, I. and Nielsen, J. and Oppert, J.M. and Stumvoll, M. and Vestergaard, H. and Zucker, J.D. and Bork, P. and Pedersen, O. and Bäckhed, F. and Clément, K. and Raes, J.
Nature 581 (7808): 310-315. 21 May 2020

Pan-cancer analysis of whole genomes.

Nature 578 (7793): 82-93. 6 February 2020

Genomic basis for RNA alterations in cancer.
Calabrese, C. and Davidson, N.R. and Demircioğlu, D. and Fonseca, N.A. and He, Y. and Kahles, A. and Lehmann, K.V. and Liu, F. and Shiraishi, Y. and Soulette, C.M. and Urban, L. and Greger, L. and Li, S. and Liu, D. and Perry, M.D. and Xiang, Q. and Zhang, F. and Zhang, J. and Bailey, P. and Erkek, S. and Hoadley, K.A. and Hou, Y. and Huska, M.R. and Kilpinen, H. and Korbel, J.O. and Marin, M.G. and Markowski, J. and Nandi, T. and Pan-Hammarström, Q. and Pedamallu, C.S. and Siebert, R. and Stark, S.G. and Su, H. and Tan, P. and Waszak, S.M. and Yung, C. and Zhu, S. and Awadalla, P. and Creighton, C.J. and Meyerson, M. and Ouellette, B.F.F. and Wu, K. and Yang, H. and Brazma, A. and Brooks, A.N. and Göke, J. and Rätsch, G. and Schwarz, R.F. and Stegle, O. and Zhang, Z.
Nature 578 (7793): 129-136. 6 February 2020

2019

Gene expression cartography.
Nitzan, M. and Karaiskos, N. and Friedman, N. and Rajewsky, N.
Nature 576 (7785): 132-137. 5 December 2019

The advent and rise of monoclonal antibodies.
Rajewsky, K.
Nature 575 (7781): 47-49. November 2019

Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy.
Lee, J. and Termglinchan, V. and Diecke, S. and Itzhaki, I. and Lam, C.K. and Garg, P. and Lau, E. and Greenhaw, M. and Seeger, T. and Wu, H. and Zhang, J.Z and Chen, X. and Gil, I.P. and Ameen, M. and Sallam, K. and Rhee, J.W. and Churko, J.M. and Chaudhary, R. and Chour, T. and Wang, P.J. and Snyder, M.P. and Chang, H.Y. and Karakikes, I. and Wu, J.C.
Nature 572 (7769): 335-340. 15 August 2019

Structure and assembly of the mitochondrial membrane remodelling GTPase Mgm1.
Faelber, K. and Dietrich, L. and Noel, J.K. and Wollweber, F. and Pfitzner, A.K. and Mühleip, A. and Sánchez, R. and Kudryashev, M. and Chiaruttini, N. and Lilie, H. and Schlegel, J. and Rosenbaum, E. and Hessenberger, M. and Matthaeus, C. and Kunz, S. and von der Malsburg, A. and Noé, F. and Roux, A. and van der Laan, M. and Kühlbrandt, W. and Daumke, O.
Nature 571 (7765): 429-433. 18 July 2019

Molecular recording of mammalian embryogenesis.
Chan, M.M. and Smith, Z.D. and Grosswendt, S. and Kretzmer, H. and Norman, T.M. and Adamson, B. and Jost, M. and Quinn, J.J. and Yang, D. and Jones, M.G. and Khodaverdian, A. and Yosef, N. and Meissner, A. and Weissman, J.S.
Nature 570 (7759): 77-82. 6 June 2019

Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts.
Eckert, M.A. and Coscia, F. and Chryplewicz, A. and Chang, J.W. and Hernandez, K.M. and Pan, S. and Tienda, S.M. and Nahotko, D.A. and Li, G. and Blaženović, I. and Lastra, R.R. and Curtis, M. and Yamada, S.D. and Perets, R. and McGregor, S.M. and Andrade, J. and Fiehn, O. and Moellering, R.E. and Mann, M. and Lengyel, E.
Nature 569 (7758): 723-728. 30 May 2019

Nitrosative stress drives heart failure with preserved ejection fraction.
Schiattarella, G.G. and Altamirano, F. and Tong, D. and French, K.M. and Villalobos, E. and Kim, S.Y. and Luo, X. and Jiang, N. and May, H.I. and Wang, Z.V. and Hill, T.M. and Mammen, P.P.A. and Huang, J. and Lee, D.I. and Hahn, V.S. and Sharma, K. and Kass, D.A. and Lavandero, S. and Gillette, T.G. and Hill, J.A.
Nature 568 (7752): 351-356. 18 April 2019

Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3.
Farrelly, L.A. and Thompson, R.E. and Zhao, S. and Lepack, A.E. and Lyu, Y. and Bhanu, N.V. and Zhang, B. and Loh, Y.H.E. and Ramakrishnan, A. and Vadodaria, K.C. and Heard, K.J. and Erikson, G. and Nakadai, T. and Bastle, R.M. and Lukasak, B.J. and Zebroski, H. and Alenina, N. and Bader, M. and Berton, O. and Roeder, R.G. and Molina, H. and Gage, F.H. and Shen, L. and Garcia, B.A. and Li, H. and Muir, T.W. and Maze, I.
Nature 567 (7749): 535-539. 28 March 2019

Tissue curvature and apicobasal mechanical tension imbalance instruct cancer morphogenesis.
Messal, H.A. and Alt, S. and Ferreira, R.M.M. and Gribben, C. and Wang, V.M.Y. and Cotoi, C.G. and Salbreux, G. and Behrens, A.
Nature 566 (7742): 126-130. 7 February 2019

2018

Structure and function of the global topsoil microbiome.
Bahram, M. and Hildebrand, F. and Forslund, S.K. and Anderson, J.L. and Soudzilovskaia, N.A. and Bodegom, P.M. and Bengtsson-Palme, J. and Anslan, S. and Coelho, L.P. and Harend, H. and Huerta-Cepas, J. and Medema, M.H. and Maltz, M.R. and Mundra, S. and Olsson, P.A. and Pent, M. and Põlme, S. and Sunagawa, S. and Ryberg, M. and Tedersoo, L. and Bork, P.
Nature 560 (7717): 233-237. 9 August 2018

Species-specific activity of antibacterial drug combinations.
Brochado, A.R. and Telzerow, A. and Bobonis, J. and Banzhaf, M. and Mateus, A. and Selkrig, J. and Huth, E. and Bassler, S. and Zamarreño Beas, J. and Zietek, M. and Ng, N. and Foerster, S. and Ezraty, B. and Py, B. and Barras, F. and Savitski, M.M. and Bork, P. and Göttig, S. and Typas, A.
Nature 559 (7713): 259-263. July 2018

Kinase-controlled phase transition of membraneless organelles in mitosis.
Rai, A.K. and Chen, J.X. and Selbach, M. and Pelkmans, L.
Nature 559 (7713): 211-216. July 2018

Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice.
Fernández, Á.F. and Sebti, S. and Wei, Y. and Zou, Z. and Shi, M. and McMillan, K.L. and He, C. and Ting, T. and Liu, Y. and Chiang, W.C. and Marciano, D.K. and Schiattarella, G.G. and Bhagat, G. and Moe, O.W. and Hu, M.C. and Levine, B.
Nature 558 (7708): 136-140. 7 June 2018

Extensive impact of non-antibiotic drugs on human gut bacteria.
Maier, L. and Pruteanu, M. and Kuhn, M. and Zeller, G. and Telzerow, A. and Anderson, E.E. and Brochado, A.R. and Fernandez, K.C. and Dose, H. and Mori, H. and Patil, K.R. and Bork, P. and Typas, A.
Nature 555 (7698): 623-628. 29 March 2018

Senescence-associated reprogramming promotes cancer stemness.
Milanovic, M. and Fan, D.N.Y. and Belenki, D. and Däbritz, J.H.M. and Zhao, Z. and Yu, Y. and Dörr, J.R. and Dimitrova, L. and Lenze, D. and Monteiro Barbosa, I.A. and Mendoza-Parra, M.A. and Kanashova, T. and Metzner, M. and Pardon, K. and Reimann, M. and Trumpp, A. and Dörken, B. and Zuber, J. and Gronemeyer, H. and Hummel, M. and Dittmar, G. and Lee, S. and Schmitt, C.A.
Nature 553 (7686): 96-100. 4 January 2018

2017

IL11 is a crucial determinant of cardiovascular fibrosis.
Schafer, S. and Viswanathan, S. and Widjaja, A.A. and Lim, W.W. and Moreno-Moral, A. and DeLaughter, D.M. and Ng, B. and Patone, G. and Chow, K. and Khin, E. and Tan, J. and Chothani, S.P. and Ye, L. and Rackham, O.J. and Ko, N.S. and Sahib, N.E. and Pua, C.J. and Zhen, N.T. and Xie, C. and Wang, M. and Maatz, H. and Lim, S. and Saar, K. and Blachut, S. and Petretto, E. and Schmidt, S. and Putoczki, T. and Guimarães-Camboa, N. and Wakimoto, H. and van Heesch, S. and Sigmundsson, K. and Lim, S.L. and Soon, J.L. and Chao, V.T. and Chua, Y.L. and Tan, T.E. and Evans, S.M. and Loh, Y.J. and Jamal, M.H. and Ong, K.K. and Chua, K.C. and Ong, B.H. and Chakaramakkil, M.J. and Seidman, J.G. and Seidman, C.E. and Hubner, N. and Sin, K.Y. and Cook, S.A.
Nature 552 (7683): 110-115. 7 December 2017

Salt-responsive gut commensal modulates T(H)17 axis and disease.
Wilck, N. and Matus, M.G. and Kearney, S.M. and Olesen, S.W. and Forslund, K. and Bartolomaeus, H. and Haase, S. and Mähler, A. and Balogh, A. and Markó, L. and Vvedenskaya, O. and Kleiner, F.H. and Tsvetkov, D. and Klug, L. and Costea, P.I. and Sunagawa, S. and Maier, L. and Rakova, N. and Schatz, V. and Neubert, P. and Frätzer, C. and Krannich, A. and Gollasch, M. and Grohme, D.A. and Côrte-Real, B.F. and Gerlach, R.G. and Basic, M. and Typas, A. and Wu, C. and Titze, J.M. and Jantsch, J. and Boschmann, M. and Dechend, R. and Kleinewietfeld, M. and Kempa, S. and Bork, P. and Linker, R.A. and Alm, E.J. and Müller, D.N.
Nature 551 (7682): 585-589. 30 November 2017

BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation.
Raffel, S. and Falcone, M. and Kneisel, N. and Hansson, J. and Wang, W. and Lutz, C. and Bullinger, L. and Poschet, G. and Nonnenmacher, Y. and Barnert, A. and Bahr, C. and Zeisberger, P. and Przybylla, A. and Sohn, M. and Tönjes, M. and Erez, A. and Adler, L. and Jensen, P. and Scholl, C. and Fröhling, S. and Cocciardi, S. and Wuchter, P. and Thiede, C. and Flörcken, A. and Westermann, J. and Ehninger, G. and Lichter, P. and Hiller, K. and Hell, R. and Herrmann, C. and Ho, A.D. and Krijgsveld, J. and Radlwimmer, B. and Trumpp, A.
Nature 551 (7680): 384-388. 16 November 2017

Single-molecule imaging reveals receptor-G protein interactions at cell surface hot spots.
Sungkaworn, T. and Jobin, M.L. and Burnecki, K. and Weron, A. and Lohse, M.J. and Calebiro, D.
Nature 550 (7677): 543-547. 26 October 2017

A reversible haploid mouse embryonic stem cell biobank resource for functional genomics.
Elling, U. and Wimmer, R.A. and Leibbrandt, A. and Burkard, T. and Michlits, G. and Leopoldi, A. and Micheler, T. and Abdeen, D. and Zhuk, S. and Aspalter, I.M. and Handl, C. and Liebergesell, J. and Hubmann, M. and Husa, A.M. and Kinzer, M. and Schuller, N. and Wetzel, E. and van de Loo, N. and Martinez, J.A.Z. and Estoppey, D. and Riedl, R. and Yang, F. and Fu, B. and Dechat, T. and Ivics, Z. and Agu, C.A. and Bell, O. and Blaas, D. and Gerhardt, H. and Hoepfner, D. and Stark, A. and Penninger, J.M.
Nature 550 (7674): 114-118. 5 October 2017

The 4D nucleome project.
Dekker, J. and Belmont, A.S. and Guttman, M. and Leshyk, V.O. and Lis, J.T. and Lomvardas, S. and Mirny, L.A. and O'Shea, C.C. and Park, P.J. and Ren, B. and Politz, J.C.R. and Shendure, J. and Zhong, S.
Nature 549 (7671): 219-226. 14 September 2017

Public antibodies to malaria antigens generated by two LAIR1 insertion modalities.
Pieper, K. and Tan, J. and Piccoli, L. and Foglierini, M. and Barbieri, S. and Chen, Y. and Silacci-Fregni, C. and Wolf, T. and Jarrossay, D. and Anderle, M. and Abdi, A. and Ndungu, F.M. and Doumbo, O.K. and Traore, B. and Tran, T.M. and Jongo, S. and Zenklusen, I. and Crompton, P.D. and Daubenberger, C. and Bull, P.C. and Sallusto, F. and Lanzavecchia, A.
Nature 548 (7669): 597-601. 31 August 2017

Polylox barcoding reveals haematopoietic stem cell fates realized in vivo.
Pei, W. and Feyerabend, T.B. and Rössler, J. and Wang, X. and Postrach, D. and Busch, K. and Rode, I. and Klapproth, K. and Dietlein, N. and Quedenau, C. and Chen, W. and Sauer, S. and Wolf, S. and Höfer, T. and Rodewald, H.Re.
Nature 548 (7668): 456-460. 24 August 2017

Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis.
Sigal, M. and Logan, C.Y. and Kapalczynska, M. and Mollenkopf, H.J. and Berger, H. and Wiedenmann, B. and Nusse, R. and Amieva, M.R. and Meyer, T.F.
Nature 548 (7668): 451-455. 24 August 2017

Cell cycle: continuous chromatin changes.
Beagrie, R.A. and Pombo, A.
Nature 547 (7661): 34-35. 6 July 2017

The B-cell receptor controls fitness of MYC-driven lymphoma cells via GSK3β inhibition.
Varano, G. and Raffel, S. and Sormani, M. and Zanardi, F. and Lonardi, S. and Zasada, C. and Perucho, L. and Petrocelli, V. and Haake, A. and Lee, A.K. and Bugatti, M. and Paul, U. and Van Anken, E. and Pasqualucci, L. and Rabadan, R. and Siebert, R. and Kempa, S. and Ponzoni, M. and Facchetti, F. and Rajewsky, K. and Casola, S.
Nature 546 (7657): 302-306. 8 June 2017

Phylogenetic ctDNA analysis depicts early stage lung cancer evolution.
Abbosh, C. and Birkbak, N.J. and Wilson, G.A. and Jamal-Hanjani, M. and Constantin, T. and Salari, R. and Quesne, J.L. and Moore, D.A. and Veeriah, S. and Rosenthal, R. and Marafioti, T. and Kirkizlar, E. and Watkins, T.B.K. and McGranahan, N. and Ward, S. and Martinson, L. and Riley, J. and Fraioli, F. and Bakir, M.A. and Grönroos, E. and Zambrana, F. and Endozo, R. and Bi, W.L. and Fennessy, F.M. and Sponer, N. and Johnson, D. and Laycock, J. and Shafi, S. and Czyzewska-Khan, J. and Rowan, A. and Chambers, T. and Matthews, N. and Turajlic, S. and Hiley, C. and Lee, S.M. and Forster, M.D. and Ahmad, T. and Falzon, M. and Borg, E. and Lawrence, D. and Hayward, M. and Kolvekar, S. and Panagiotopoulos, N. and Janes, S.M. and Thakrar, R. and Ahmed, A. and Blackhall, F. and Summers, Y. and Hafez, D. and Naik, A. and Ganguly, A. and Kareht, S. and Shah, R. and Joseph, L. and Quinn, A.M. and Crosbie, P. and Naidu, B. and Middleton, G. and Langman, G. and Trotter, S. and Nicolson, M. and Remmen, H. and Kerr, K. and Chetty, M. and Gomersall, L. and Fennell, D.A. and Nakas, A. and Rathinam, S. and Anand, G. and Khan, S. and Russell, P. and Ezhil, V. and Ismail, B. and Irvin-Sellers, M. and Prakash, V. and Lester, J.F. and Kornaszewska, M. and Attanoos, R. and Adams, H. and Davies, H. and Oukrif, D. and Akarca, A.U. and Hartley, J.A. and Lowe, H.L. and Lock, S. and Iles, N. and Bell, H. and Ngai, Y. and Elgar, G. and Szallasi, Z. and Schwarz, R.F. and Herrero, J. and Stewart, A. and Quezada, S.A. and Van Loo, P. and Dive, C. and Lin, C.J. and Rabinowitz, M. and Aerts, H.J.W.L. and Hackshaw, A. and Shaw, J.A. and Zimmermann, B.G. and Swanton, C.
Nature 545 (7655): 446-451. 25 May 2017

FGF-dependent metabolic control of vascular development.
Yu, P. and Wilhelm, K. and Dubrac, A. and Tung, J.K. and Alves, T.C. and Fang, J.S. and Xie, Y. and Zhu, Ji. and Chen, Z. and De Smet, F. and Zhang, J. and Jin, S.W. and Sun, L. and Sun, H. and Kibbey, R.G. and Hirschi, K.K. and Hay, N. and Carmeliet, P. and Chittenden, T.W. and Eichmann, A. and Potente, M. and Simons, M.
Nature 545 (7653): 224-228. 11 May 2017

Tumour ischaemia by interferon-γ resembles physiological blood vessel regression.
Kammertoens, T. and Friese, C. and Arina, A. and Idel, C. and Briesemeister, D. and Rothe, M. and Ivanov, A. and Szymborska, A. and Patone, G. and Kunz, S. and Sommermeyer, D. and Engels, B. and Leisegang, M. and Textor, A. and Fehling, H.J. and Fruttiger, M. and Lohoff, M. and Herrmann, A. and Yu, H. and Weichselbaum, R. and Uckert, W. and Hübner, N. and Gerhardt, H. and Beule, D. and Schreiber, H. and Blankenstein, T.
Nature 545 (7652): 98-102. 4 May 2017

Complex multi-enhancer contacts captured by genome architecture mapping.
Beagrie, R.A. and Scialdone, A. and Schueler, M. and Kraemer, D.C.A. and Chotalia, M. and Xie, S.Q. and Barbieri, M. and de Santiago, I. and Lavitas, L.M. and Branco, M.R. and Fraser, J. and Dostie, J. and Game, L. and Dillon, N. and Edwards, P.A.W. and Nicodemi, M. and Pombo, A.
Nature 543 (7646): 519-524. 23 March 2017

Hypoxia induces heart regeneration in adult mice.
Nakada, Y. and Canseco, D.C. and Thet, S. and Abdisalaam, S. and Asaithamby, A. and Santos, C.X. and Shah, A.M. and Zhang, Hua and Faber, J.E. and Kinter, M.T. and Szweda, L.I. and Xing, C. and Hu, Z. and Deberardinis, R.J. and Schiattarella, G. and Hill, J.A. and Oz, O. and Lu, Z. and Zhang, C.C. and Kimura, W. and Sadek, H.A.
Nature 541 (7636): 222-227. 12 January 2017

2016

Formation of new chromatin domains determines pathogenicity of genomic duplications.
Franke, M. and Ibrahim, D.M. and Andrey, G. and Schwarzer, W. and Heinrich, V. and Schoepflin, R. and Kraft, K. and Kempfer, R. and Jerkovic, I. and Chan, W.L. and Spielmann, M. and Timmermann, B. and Wittler, L. and Kurth, I. and Cambiaso, P. and Zuffardi, O. and Houge, G. and Lambie, L. and Brancati, F. and Pombo, A. and Vingron, M. and Spitz, F. and Mundlos, S.
Nature 538 (7624): 265-269. 13 October 2016

Ecogenomics and potential biogeochemical impacts of globally abundant ocean viruses.
Roux, S. and Brum, J.R. and Dutilh, B.E. and Sunagawa, S. and Duhaime, M.B. and Loy, A. and Poulos, B.T. and Solonenko, N. and Lara, E. and Poulain, J. and Pesant, S. and Kandels-Lewis, S. and Dimier, C. and Picheral, M. and Searson, S. and Cruaud, C. and Alberti, A. and Duarte, C.M. and Gasol, J.M. and Vaque, D. and Bork, P. and Acinas, S.G. and Wincker, P. and Sullivan, M.B.
Nature 537 (7622): 689-693. 29 September 2016

Human gut microbes impact host serum metabolome and insulin sensitivity.
Pedersen, H.K. and Gudmundsdottir, V. and Nielsen, H.B. and Hyotylainen, T. and Nielsen, T. and Jensen, B.A.H. and Forslund, K. and Hildebrand, F. and Prifti, E. and Falony, G. and Le Chatelier, E. and Levenez, F. and Doré, J. and Mattila, I. and Plichta, D.R. and Pöhö, P. and Hellgren, L.I. and Arumugam, M. and Sunagawa, S. and Vieira-Silva, S. and Jørgensen, T. and Holm, J.B. and Trošt, K. and Kristiansen, K. and Brix, S. and Raes, J. and Wang, J. and Hansen, T. and Bork, P. and Brunak, S. and Oresic, M. and Ehrlich, S.D. and Pedersen, O.
Nature 535 (7612): 376-381. 21 July 2016

Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma.
Fox, R.G. and Lytle, N.K. and Jaquish, D.V. and Park, F.D. and Ito, T. and Bajaj, J. and Koechlein, C.S. and Zimdahl, B. and Yano, M. and Kopp, J. and Kritzik, M. and Sicklick, J. and Sander, M. and Grandgenett, P.M. and Hollingsworth, M.A. and Shibata, S. and Pizzo, D. and Valasek, M. and Sasik, R. and Scadeng, M. and Okano, H. and Kim, Y. and MacLeod, A.R. and Lowy, A.M. and Reya, T.
Nature 534 (7607): 407-411. 16 June 2016

Proteogenomics connects somatic mutations to signalling in breast cancer.
Mertins, P. and Mani, D.R. and Ruggles, K.V. and Gillette, M.A. and Clauser, K.R. and Wang, P. and Wang, X. and Qiao, J.W. and Cao, S. and Petralia, F. and Kawaler, E. and Mundt, F. and Krug, K. and Tu, Z. and Lei, J.T. and Gatza, M.L. and Wilkerson, M. and Perou, C.M. and Yellapantula, V. and Huang, K.L. and Lin, C. and McLellan, M.D. and Yan, P. and Davies, S.R. and Townsend, R.R. and Skates, S.J. and Wang, J. and Zhang, B. and Kinsinger, C.R. and Mesri, M. and Rodriguez, H. and Ding, L. and Paulovich, A.G. and Fenyoe, D. and Ellis, M.J. and Carr, S.A.
Nature 534 (7605): 55-62. 2 June 2016

Plankton networks driving carbon export in the oligotrophic ocean.
Guidi, L. and Chaffron, S. and Bittner, L. and Eveillard, D. and Larhlimi, A. and Roux, S. and Darzi, Y. and Audic, S. and Berline, L. and Brum, J. and Coelho, L.P. and Espinoza, J.C.I. and Malviya, S. and Sunagawa, S. and Dimier, C. and Kandels-Lewis, S. and Picheral, M. and Poulain, J. and Searson, S. and Stemmann, L. and Not, F. and Hingamp, P. and Speich, S. and Follows, M. and Karp-Boss, L. and Boss, E. and Ogata, H. and Pesant, S. and Weissenbach, J. and Wincker, P. and Acinas, S.G. and Bork, P. and de Vargas, C. and Iudicone, D. and Sullivan, M.B. and Raes, J. and Karsenti, E. and Bowler, C. and Gorsky, G.
Nature 532 (7600): 465-470. 28 April 2016

FOXO1 couples metabolic activity and growth state in the vascular endothelium.
Wilhelm, K. and Happel, K. and Eelen, G. and Schoors, S. and Oellerich, M.F. and Lim, R. and Zimmermann, B. and Aspalter, I.M. and Franco, C.A. and Boettger, T. and Braun, T. and Fruttiger, M. and Rajewsky, K. and Keller, C. and Brüning, J.C. and Gerhardt, H. and Carmeliet, P. and Potente, M.
Nature 529 (7585): 216-220. 14 January 2016

A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens.
Tan, J. and Pieper, K. and Piccoli, L. and Abdi, A. and Foglierini, M. and Geiger, R. and Tully, C.M. and Jarrossay, D. and Ndungu, F.M. and Wambua, J. and Bejon, P. and Silacci Fregni, C. and Fernandez-Rodriguez, B. and Barbieri, S. and Bianchi, S. and Marsh, K. and Thathy, V. and Corti, D. and Sallusto, F. and Bull, P. and Lanzavecchia, A.
Nature 529 (7584): 105-109. 7 January 2016

2015

Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota.
Forslund, K. and Hildebrandt, F. and Nielsen, T. and Falony, G. and Le Chatelier, E. and Sunagawa, S. and Prifti, E. and Vieira-Silva, S. and Gudmundsdottir, V. and Pedersen, H.K. and Arumugam, M. and Kristiansen, K. and Voigt, A.Y. and Vestergaard, H. and Hercog, R. and Costea, P.I. and Kultima, J.R. and Li, J. and Jørgensen, T. and Levenez, F. and Dore, J. and Nielsen, H.B. and Brunak, S. and Raes, J. and Hansen, T. and Wang, J. and Ehrlich, S.D. and Bork, P. and Pedersen, O.
Nature 528 (7581): 262-266. 10 December 2015

Telomerase activation by genomic rearrangements in high-risk neuroblastoma.
Peifer, M. and Hertwig, F. and Roels, F. and Dreidax, D. and Gartlgruber, M. and Menon, R. and Krämer, A. and Roncaioli, J.L. and Sand, F. and Heuckmann, J.M. and Ikram, F. and Schmidt, R. and Ackermann, S. and Engesser, A. and Kahlert, Y. and Vogel, W. and Altmüller, J. and Nürnberg, P. and Thierry-Mieg, J. and Thierry-Mieg, D. and Mariappan, A. and Heynck, S. and Mariotti, E. and Henrich, K.O. and Gloeckner, C. and Bosco, G. and Leuschner, I. and Schweiger, M.R. and Savelyeva, L. and Watkins, S.C. and Shao, C. and Bell, E. and Höfer, T. and Achter, V. and Lang, U. and Theissen, J. and Volland, R. and Saadati, M. and Eggert, A. and de Wilde, B. and Berthold, F. and Peng, Z. and Zhao, C. and Shi, L. and Ortmann, M. and Büttner, R. and Perner, S. and Hero, B. and Schramm, A. and Schulte, J.H. and Herrmann, C. and O'Sullivan, R.J. and Westermann, F. and Thomas, R.K. and Fischer, M.
Nature 526 (7575): 700-704. 29 October 2015

Crystal structure of the dynamin tetramer.
Reubold, T.F. and Faelber, K. and Plattner, N. and Posor, Y. and Ketel, K. and Curth, U. and Schlegel, J. and Anand, R. and Manstein, D.J. and Noé, F. and Haucke, V. and Daumke, O. and Eschenburg, S.
Nature 525 (7569): 404-408. 17 September 2015

Comprehensive genomic profiles of small cell lung cancer.
George, J. and Lim, J.S. and Jang, S.J. and Cun, Y. and Ozretić, L. and Kong, G. and Leenders, F. and Lu, X. and Fernández-Cuesta, L. and Bosco, G. and Müller, C. and Dahmen, I. and Jahchan, N.S. and Park, K.S. and Yang, D. and Karnezis, A.N. and Vaka, D. and Torres, A. and Wang, M.S. and Korbel, J.O. and Menon, R. and Chun, S.M. and Kim, D. and Wilkerson, M. and Hayes, N. and Engelmann, D. and Pützer, B. and Bos, M. and Michels, S. and Vlasic, I. and Seidel, D. and Pinther, B. and Schaub, P. and Becker, C. and Altmüller, J. and Yokota, J. and Kohno, T. and Iwakawa, R. and Tsuta, K. and Noguchi, M. and Muley, T. and Hoffmann, H. and Schnabel, P.A. and Petersen, I. and Chen, Y. and Soltermann, A. and Tischler, V. and Choi, C.M. and Kim, Y.H. and Massion, P.P. and Zou, Y. and Jovanovic, D. and Kontic, M. and Wright, G.M. and Russell, P.A. and Solomon, B. and Koch, I. and Lindner, M. and Muscarella, L.A. and la Torre, A. and Field, J.K. and Jakopovic, M. and Knezevic, J. and Castaños-Vélez, E. and Roz, L. and Pastorino, U. and Brustugun, O.T. and Lund-Iversen, M. and Thunnissen, E. and Köhler, J. and Schuler, M. and Botling, J. and Sandelin, M. and Sanchez-Cespedes, M. and Salvesen, H.B. and Achter, V. and Lang, U. and Bogus, M. and Schneider, P.M. and Zander, T. and Ansén, S. and Hallek, M. and Wolf, J. and Vingron, M. and Yatabe, Y. and Travis, W.D. and Nürnberg, P. and Reinhardt, C. and Perner, S. and Heukamp, L. and Büttner, R. and Haas, S.A. and Brambilla, E. and Peifer, M. and Sage, J. and Thomas, R.K.
Nature 524 (7563): 47-53. 6 August 2015

Genomic profiling of DNA methyltransferases reveals a role for DNMT3B in genic methylation.
Baubec, T. and Colombo, D.F. and Wirbelauer, C. and Schmidt, J. and Burger, L. and Krebs, A.R. and Akalin, A. and Schübeler, D.
Nature 520 (7546): 243-247. 9 April 2015

Fatty acid carbon is essential for dNTP synthesis in endothelial cells.
Schoors, S. and Bruning, U. and Missiaen, R. and Queiroz, K.C.S. and Borgers, G. and Elia, I. and Zecchin, A. and Cantelmo, A.R. and Christen, S. and Goveia, J. and Heggermont, W. and Goddé, L. and Vinckier, S. and Van Veldhoven, P.P. and Eelen, G. and Schoonjans, L. and Gerhardt, H. and Dewerchin, M. and Baes, M. and De Bock, K. and Ghesquière, B. and Lunt, S.Y. and Fendt, S.M. and Carmeliet, P.
Nature 520 (7546): 192-197. 9 April 2015

PLD3 in non-familial Alzheimer's disease.
Heilmann, S. and Drichel, D. and Clarimon, J. and Fernández, V. and Lacour, A. and Wagner, H. and Thelen, M. and Hernández, I. and Fortea, J. and Alegret, M. and Blesa, R. and Mauleón, A. and Roca, M.R. and Kornhuber, J. and Peters, O. and Heun, R. and Frölich, L. and Hüll, M. and Heneka, M.T. and Rüther, E. and Riedel-Heller, S. and Scherer, M. and Wiltfang, J. and Jessen, F. and Becker, T. and Tárraga, L. and Boada, M. and Maier, W. and Lleó, A. and Ruiz, A. and Nöthen, M.M. and Ramirez, A.
Nature 520 (7545): E3-E5. 2 April 2015

hiCLIP reveals the in vivo atlas of mRNA secondary structures recognized by Staufen 1.
Sugimoto, Y. and Vigilante, A. and Darbo, E. and Zirra, A. and Militti, C. and D'Ambrogio, A. and Luscombe, N.M. and Ule, J.
Nature 519 (7544): 491-494. 26 March 2015

2014

Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells.
Wang, J. and Xie, G. and Singh, M. and Ghanbarian, A.T. and Raskó, T. and Szvetnik, A. and Cai, H. and Besser, D. and Prigione, A. and Fuchs, N.V. and Schumann, G.G. and Chen, W. and Lorincz, M.C. and Ivics, Z. and Hurst, L.D. and Izsvák, Z.
Nature 516 (7531): 405-409. 18 December 2014

Piezo2 is the major transducer of mechanical forces for touch sensation in mice.
Ranade, S.S. and Woo, S.H. and Dubin, A.E. and Moshourab, R.A. and Wetzel, C. and Petrus, M. and Mathur, J. and Bégay, V. and Coste, B. and Mainquist, J. and Wilson, A.J. and Francisco, A.G. and Reddy, K. and Qiu, Z. and Wood, J.N. and Lewin, G.R. and Patapoutian, A.
Nature 516 (7529): 121-125. 4 December 2014

Proteogenomic characterization of human colon and rectal cancer.
Zhang, B. and Wang, J. and Wang, X. and Zhu, J. and Liu, Q. and Shi, Z. and Chambers, M.C. and Zimmerman, L.J. and Shaddox, K.F. and Kim, S. and Davies, S.R. and Wang, S. and Wang, P. and Kinsinger, C.R. and Rivers, R.C. and Rodriguez, H. and Townsend, R.R. and Ellis, M.J.C. and Carr, S.A. and Tabb, D.L. and Coffey, R.J. and Slebos, R.J.C. and Liebler, D.C.
Nature 513 (7518): 382-387. 18 September 2014

Gibbon genome and the fast karyotype evolution of small apes.
Carbone, L. and Harris, R.A. and Gnerre, S. and Veeramah, K.R. and Lorente-Galdos, B. and Huddleston, J. and Meyer, T.J. and Herrero, J. and Roos, C. and Aken, B. and Anaclerio, F. and Archidiacono, N. and Baker, C. and Barrell, D. and Batzer, M.A. and Beal, K. and Blancher, A. and Bohrson, C.L. and Brameier, M. and Campbell, M.S. and Capozzi, O. and Casola, C. and Chiatante, G. and Cree, A. and Damert, A. and de Jong, P.J. and Dumas, L. and Fernandez-Callejo, M. and Flicek, P. and Fuchs, N.V. and Gut, I. and Gut, M. and Hahn, M.W. and Hernandez-Rodriguez, J. and Hillier, L.W. and Hubley, R. and Ianc, B. and Izsvák, Z. and Jablonski, N.G. and Johnstone, L.M. and Karimpour-Fard, A. and Konkel, M.K. and Kostka, D. and Lazar, N.H. and Lee, S.L. and Lewis, L.R. and Liu, Y. and Locke, D.P. and Mallick, S. and Mendez, F.L. and Muffato, M. and Nazareth, L.V. and Nevonen, K.A. and O'Bleness, M. and Ochis, C. and Odom, D.T. and Pollard, K.S. and Quilez, J. and Reich, D. and Rocchi, M. and Schumann, G.G. and Searle, S. and Sikela, J.M. and Skollar, G. and Smit, A. and Sonmez, K. and ten Hallers, B. and Terhune, E. and Thomas, G.W.C. and Ullmer, B. and Ventura, M. and Walker, J.A. and Wall, J.D. and Walter, L. and Ward, M.C. and Wheelan, S.J. and Whelan, C.W. and White, S. and Wilhelm, L.J. and Woerner, A.E. and Yandell, M. and Zhu, B. and Hammer, M.F. and Marques-Bonet, T. and Eichler, E.E. and Fulton, L. and Fronick, C. and Muzny, D.M. and Warren, W.C. and Worley, K.C. and Rogers, J. and Wilson, R.K. and Gibbs, R.A.
Nature 513 (7517): 195-201. 11 September 2014

Developmental biology: it takes muscle to make blood cells.
Sawamiphak, S. and Stainier, D.Y.R.
Nature 512 (7514): 257-258. 21 August 2014

Two independent transcription initiation codes overlap on vertebrate core promoters.
Haberle, V. and Li, N. and Hadzhiev, Y. and Plessy, C. and Previti, C. and Nepal, C. and Gehrig, J. and Dong, X. and Akalin, A. and Suzuki, A.M. and van IJcken, W.F.J. and Armant, O. and Ferg, M. and Strähle, U. and Carninci, P. and Müller, F. and Lenhard, B.
Nature 507 (7492): 381-385. 20 March 2014

Bone biology: vessels of rejuvenation.
le Noble, F. and le Noble, J.
Nature 507 (7492): 313-314. 20 March 2014

2013

Synthetic lethal metabolic targeting of cellular senescence in cancer therapy.
Dörr, J.R. and Yu, Y. and Milanovic, M. and Beuster, G. and Zasada, C. and Däbritz, J.H.M. and Lisec, J. and Lenze, D. and Gerhardt, A. and Schleicher, K. and Kratzat, S. and Purfürst, B. and Walenta, S. and Mueller-Klieser, W. and Gräler, M. and Hummel, M. and Keller, U. and Buck, A.K. and Dörken, B. and Willmitzer, L. and Reimann, M. and Kempa, S. and Lee, S. and Schmitt, C.A.
Nature 501 (7467): 421-425. 19 September 2013

M-CSF instructs myeloid lineage fate in single haematopoietic stem cells.
Mossadegh-Keller, N. and Sarrazin, S. and Kandalla, P.K. and Espinosa, L. and Stanley, E.R. and Nutt, S.L. and Moore, J. and Sieweke, M.H.
Nature 497 (7448): 239-243. 9 May 2013

Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells.
Kleinewietfeld, M. and Manzel, A. and Titze, J. and Kvakan, H. and Yosef, N. and Linker, R.A. and Muller, D.N. and Hafler, D.A.
Nature 496 (7446): 518-522. 25 April 2013

Circular RNAs are a large class of animal RNAs with regulatory potency.
Memczak, S. and Jens, M. and Elefsinioti, A. and Torti, F. and Krueger, J. and Rybak, A. and Maier, L. and Mackowiak, S.D. and Gregersen, L.H. and Munschauer, M. and Loewer, A. and Ziebold, U. and Landthaler, M. and Kocks, C. and le Noble, F. and Rajewsky, N.
Nature 495 (7441): 333-338. 21 March 2013

MicroRNA-34a regulates cardiac ageing and function.
Boon, R.A. and Iekushi, K. and Lechner, S. and Seeger, T. and Fischer, A. and Heydt, S. and Kaluza, D. and Tréguer, K. and Carmona, G. and Bonauer, A. and Horrevoets, A.J.G. and Didier, N. and Girmatsion, Z. and Biliczki, P. and Ehrlich, J.R. and Katus, H.A. and Müller, O.J. and Potente, M. and Zeiher, A.M. and Hermeking, H. and Dimmeler, S.
Nature 495 (7439): 107-110. 7 March 2013

Genomic variation landscape of the human gut microbiome.
Schloissnig, S. and Arumugam, M. and Sunagawa, S. and Mitreva, M. and Tap, J. and Zhu, A. and Waller, A. and Mende, D.R. and Kultima, J.R. and Martin, J. and Kota, K. and Sunyaev, S.R. and Weinstock, G.M. and Bork, P.
Nature 493 (7430): 45-50. 3 January 2013

2012

FMRP targets distinct mRNA sequence elements to regulate protein expression.
Ascano, M. and Mukherjee, N. and Bandaru, P. and Miller, J.B. and Nusbaum, J.D. and Corcoran, D.L. and Langlois, C. and Munschauer, M. and Dewell, S. and Hafner, M. and Williams, Z. and Ohler, U. and Tuschl, T.
Nature 492 (7429): 382-386. 20 December 2012

Tissue engineering: Blood vessels on a chip.
Franco, C. and Gerhardt, H.
Nature 488 (7412): 465-466. 23 August 2012

The clonal and mutational evolution spectrum of primary triple-negative breast cancers.
Shah, S.P. and Roth, A. and Goya, R. and Oloumi, A. and Ha, G. and Zhao, Y. and Turashvili, G. and Ding, J. and Tse, K. and Haffari, G. and Bashashati, A. and Prentice, L.M. and Khattra, J. and Burleigh, A. and Yap, D. and Bernard, V. and McPherson, A. and Shumansky, K. and Crisan, A. and Giuliany, R. and Heravi-Moussavi, A. and Rosner, J. and Lai, D. and Birol, I. and Varhol, R. and Tam, A. and Dhalla, N. and Zeng, T. and Ma, K. and Chan, S.K. and Griffith, M. and Moradian, A. and Cheng, S.W.G. and Morin, G.B. and Watson, P. and Gelmon, K. and Chia, S. and Chin, S.F. and Curtis, C. and Rueda, O.M. and Pharoah, P.D. and Damaraju, S. and Mackey, J. and Hoon, K. and Harkins, T. and Tadigotla, V. and Sigaroudinia, M. and Gascard, P. and Tlsty, T. and Costello, J.F. and Meyer, I.M. and Eaves, C.J. and Wasserman, W.W. and Jones, S. and Huntsman, D. and Hirst, M. and Caldas, C. and Marra, M.A. and Aparicio, S.
Nature 486 (7403): 395-399. 21 June 2012

Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2.
Schmeisser, M.J. and Ey, E. and Wegener, S. and Bockmann, J. and Stempel, A.V. and Kuebler, A. and Janssen, A.L. and Udvardi, P.T. and Shiban, E. and Spilker, C. and Balschun, D. and Skryabin, B.V. and Dieck, S.t. and Smalla, K.H. and Montag, D. and Leblond, C.S. and Faure, P. and Torquet, N. and Le Sourd, A.M. and Toro, R. and Grabrucker, A.M. and Shoichet, S.A. and Schmitz, D. and Kreutz, M.R. and Bourgeron, T. and Gundelfinger, E.D. and Boeckers, T.M.
Nature 486 (7402): 256-260. 29 April 2012

Deregulated MYC expression induces dependence upon AMPK-related kinase 5.
Liu, L. and Ulbrich, J. and Mueller, J. and Wuestefeld, T. and Aeberhard, L. and Kress, T.R. and Muthalagu, N. and Rycak, L. and Rudalska, R. and Moll, R. and Kempa, S. and Zender, L. and Eilers, M. and Murphy, D.J.
Nature 483 (7391): 608-612. 29 March 2012

2011

Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function.
McDermott-Roe, C. and Ye, J. and Ahmed, R. and Sun, X.M. and Serafin, A. and Ware, J. and Bottolo, L. and Muckett, P. and Canas, X. and Zhang, J. and Rowe, G.C. and Buchan, R. and Lu, H. and Braithwaite, A. and Mancini, M. and Hauton, D. and Marti, R. and Garcia-Arumi, E. and Hubner, N. and Jacob, H. and Serikawa, T. and Zidek, V. and Papousek, F. and Kolar, F. and Cardona, M. and Ruiz-Meana, M. and Garcia-Dorado, D. and Comella, J.X. and Felkin, L.E. and Barton, P.J. and Arany, Z. and Pravenec, M. and Petretto, E. and Sanchis, D. and Cook, S.A.
Nature 478 (7367): 114-118. 6 October 2011

Deep sequencing reveals 50 novel genes for recessive cognitive disorders.
Najmabadi, H. and Hu, H. and Garshasbi, M. and Zemojtel, T. and Abedini, S.S. and Chen, W. and Hosseini, M. and Behjati, F. and Haas, S. and Jamali, P. and Zecha, A. and Mohseni, M. and Puettmann, L. and Vahid, L.N. and Jensen, C. and Moheb, L.A. and Bienek, M. and Larti, F. and Mueller, I. and Weissmann, R. and Darvish, H. and Wrogemann, K. and Hadavi, V. and Lipkowitz, B. and Esmaeeli-Nieh, S. and Wieczorek, D. and Kariminejad, R. and Firouzabadi, S.G. and Cohen, M. and Fattahi, Z. and Rost, I. and Mojahedi, F. and Hertzberg, C. and Dehghan, A. and Rajab, A. and Banavandi, M.J.S. and Hoffer, J. and Falah, M. and Musante, L. and Kalscheuer, V. and Ullmann, R. and Kuss, A.W. and Tzschach, A. and Kahrizi, K. and Ropers, H.H.
Nature 478 (7367): 57-63. 6 October 2011

Crystal structure of nucleotide-free dynamin.
Faelber, K. and Posor, Y. and Gao, S. and Held, M. and Roske, Y. and Schulze, D. and Haucke, V. and Noe, F. and Daumke, O.
Nature 477 (7366): 556-560. 29 September 2011

Stem cells: Orphan receptors find a home.
Birchmeier, W.
Nature 476 (7360): 287-288. 18 August 2011

Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma.
Morin, R.D. and Mendez-Lago, M. and Mungall, A.J. and Goya, R. and Mungall, K.L. and Corbett, R.D. and Johnson, N.A. and Severson, T.M. and Chiu, R. and Field, M. and Jackman, S. and Krzywinski, M. and Scott, D.W. and Trinh, D.L. and Tamura-Wells, J. and Li, S. and Firme, M.R. and Rogic, S. and Griffith, M. and Chan, S. and Yakovenko, O. and Meyer, I.M. and Zhao, E.Y. and Smailus, D. and Moksa, M. and Chittaranjan, S. and Rimsza, L. and Brooks-Wilson, A. and Spinelli, J.J. and Ben-Neriah, S. and Meissner, B. and Woolcock, B. and Boyle, M. and McDonald, H. and Tam, A. and Zhao, Y. and Delaney, A. and Zeng, T. and Tse, K. and Butterfield, Y. and Birol, I. and Holt, R. and Schein, J. and Horsman, D.E. and Moore, R. and Jones, S.J.M. and Connors, J.M. and Hirst, M. and Gascoyne, R.D. and Marra, M.A.
Nature 476 (7360): 298-303. 18 August 2011

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
Sawcer, S. and Hellenthal, G. and Pirinen, M. and Spencer, C.C. and Patsopoulos, N.A. and Moutsianas, L. and Dilthey, A. and Su, Z. and Freeman, C. and Hunt, S.E. and Edkins, S. and Gray, E. and Booth, D.R. and Potter, S.C. and Goris, A. and Band, G. and Oturai, A.B. and Strange, A. and Saarela, J. and Bellenguez, C. and Fontaine, B. and Gillman, M. and Hemmer, B. and Gwilliam, R. and Zipp, F. and Jayakumar, A. and Martin, R. and Leslie, S. and Hawkins, S. and Giannoulatou, E. and D'alfonso, S. and Blackburn, H. and Boneschi, F.M. and Liddle, J. and Harbo, H.F. and Perez, M.L. and Spurkland, A. and Waller, M.J. and Mycko, M.P. and Ricketts, M. and Comabella, M. and Hammond, N. and Kockum, I. and McCann, O.T. and Ban, M. and Whittaker, P. and Kemppinen, A. and Weston, P. and Hawkins, C. and Widaa, S. and Zajicek, J. and Dronov, S. and Robertson, N. and Bumpstead, S.J. and Barcellos, L.F. and Ravindrarajah, R. and Abraham, R. and Alfredsson, L. and Ardlie, K. and Aubin, C. and Baker, A. and Baker, K. and Baranzini, S.E. and Bergamaschi, L. and Bergamaschi, R. and Bernstein, A. and Berthele, A. and Boggild, M. and Bradfield, J.P. and Brassat, D. and Broadley, S.A. and Buck, D. and Butzkueven, H. and Capra, R. and Carroll, W.M. and Cavalla, P. and Celius, E.G. and Cepok, S. and Chiavacci, R. and Clerget-Darpoux, F. and Clysters, K. and Comi, G. and Cossburn, M. and Cournu-Rebeix, I. and Cox, M.B. and Cozen, W. and Cree, B.A. and Cross, A.H. and Cusi, D. and Daly, M.J. and Davis, E. and de Bakker, P.I. and Debouverie, M. and D'hooghe, M.B. and Dixon, K. and Dobosi, R. and Dubois, B. and Ellinghaus, D. and Elovaara, I. and Esposito, F. and Fontenille, C. and Foote, S. and Franke, A. and Galimberti, D. and Ghezzi, A. and Glessner, J. and Gomez, R. and Gout, O. and Graham, C. and Grant, S.F. and Guerini, F.R. and Hakonarson, H. and Hall, P. and Hamsten, A. and Hartung, H.P. and Heard, R.N. and Heath, S. and Hobart, J. and Hoshi, M. and Infante-Duarte, C. and Ingram, G. and Ingram, W. and Islam, T. and Jagodic, M. and Kabesch, M. and Kermode, A.G. and Kilpatrick, T.J. and Kim, C. and Klopp, N. and Koivisto, K. and Larsson, M. and Lathrop, M. and Lechner-Scott, J.S. and Leone, M.A. and Leppa, V. and Liljedahl, U. and Bomfim, I.L. and Lincoln, R.R. and Link, J. and Liu, J. and Lorentzen, A.R. and Lupoli, S. and Macciardi, F. and Mack, T. and Marriott, M. and Martinelli, V. and Mason, D. and McCauley, J.L. and Mentch, F. and Mero, I.L. and Mihalova, T. and Montalban, X. and Mottershead, J. and Myhr, K.M. and Naldi, P. and Ollier, W. and Page, A. and Palotie, A. and Pelletier, J. and Piccio, L. and Pickersgill, T. and Piehl, F. and Pobywajlo, S. and Quach, H.L. and Ramsay, P.P. and Reunanen, M. and Reynolds, R. and Rioux, J.D. and Rodegher, M. and Roesner, S. and Rubio, J.P. and Ruckert, I.M. and Salvetti, M. and Salvi, E. and Santaniello, A. and Schaefer, C.A. and Schreiber, S. and Schulze, C. and Scott, R.J. and Sellebjerg, F. and Selmaj, K.W. and Sexton, D. and Shen, L. and Simms-Acuna, B. and Skidmore, S. and Sleiman, P.M. and Smestad, C. and Sorensen, P.S. and Sondergaard, H.B. and Stankovich, J. and Strange, R.C. and Sulonen, A.M. and Sundqvist, E. and Syvanen, A.C. and Taddeo, F. and Taylor, B. and Blackwell, J.M. and Tienari, P. and Bramon, E. and Tourbah, A. and Brown, M.A. and Tronczynska, E. and Casas, J.P. and Tubridy, N. and Corvin, A. and Vickery, J. and Jankowski, J. and Villoslada, P. and Markus, H.S. and Wang, K. and Mathew, C.G. and Wason, J. and Palmer, C.N. and Wichmann, H.E. and Plomin, R. and Willoughby, E. and Rautanen, A. and Winkelmann, J. and Wittig, M. and Trembath, R.C. and Yaouanq, J. and Viswanathan, A.C. and Zhang, H. and Wood, N.W. and Zuvich, R. and Deloukas, P. and Langford, C. and Duncanson, A. and Oksenberg, J.R. and Pericak-Vance, M.A. and Haines, J.L. and Olsson, T. and Hillert, J. and Ivinson, A.J. and De Jager, P.L. and Peltonen, L. and Stewart, G.J. and Hafler, D.A. and Hauser, S.L. and McVean, G. and Donnelly, P. and Compston, A.
Nature 476 (7359): 214-219. 10 August 2011

Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells.
Stefater, J.A. and Lewkowich, I. and Rao, S. and Mariggi, G. and Carpenter, A.C. and Burr, A.R. and Fan, J. and Ajima, R. and Molkentin, J.D. and Williams, B.O. and Wills-Karp, M. and Pollard, J.W. and Yamaguchi, T. and Ferrara, N. and Gerhardt, H. and Lang, R.A.
Nature 474 (7352): 511-515. 23 June 2011

Global quantification of mammalian gene expression control.
Schwanhaeusser, B. and Busse, D. and Li, N. and Dittmar, G. and Schuchhardt, J. and Wolf, J. and Chen, W. and Selbach, M.
Nature 473 (7347): 337-342. 19 May 2011

Enterotypes of the human gut microbiome.
Arumugam, M. and Raes, J. and Pelletier, E. and Le Paslier, D. and Yamada, T. and Mende, D.R. and Fernandes, G.R. and Tap, J. and Bruls, T. and Batto, J.M. and Bertalan, M. and Borruel, N. and Casellas, F. and Fernandez, L. and Gautier, L. and Hansen, T. and Hattori, M. and Hayashi, T. and Kleerebezem, M. and Kurokawa, K. and Leclerc, M. and Levenez, F. and Manichanh, C. and Nielsen, H.B. and Nielsen, T. and Pons, N. and Poulain, J. and Qin, J. and Sicheritz-Ponten, T. and Tims, S. and Torrents, D. and Ugarte, E. and Zoetendal, E.G. and Wang, J. and Guarner, F. and Pedersen, O. and de Vos, W.M. and Brunak, S. and Dore, J. and Weissenbach, J. and Ehrlich, S.D. and Bork, P.
Nature 473 (7346): 174-180. 12 May 2011

Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase.
Guarani, V. and Deflorian, G. and Franco, C.A. and Krüger, M. and Phng, L.K. and Bentley, K. and Toussaint, L. and Dequiedt, F. and Mostoslavsky, R. and Schmidt, M.H.H. and Zimmermann, B. and Brandes, R.P. and Mione, M. and Westphal, C.H. and Braun, T. and Zeiher, A.M. and Gerhardt, H. and Dimmeler, S. and Potente, M.
Nature 473 (7346): 234-238. 12 May 2011

2010

Gene expression divergence recapitulates the developmental hourglass model.
Kalinka, A.T. and Varga, K.M. and Gerrard, D.T. and Preibisch, S. and Corcoran, D.L. and Jarrells, J. and Ohler, U. and Bergman, C.M. and Tomancak, P.
Nature 468 (7325): 811-814. 9 December 2010

A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk.
Heinig, M. and Petretto, E. and Wallace, C. and Bottolo, L. and Rotival, M. and Lu, H. and Li, Y. and Sarwar, R. and Langley, S.R. and Bauerfeind, A. and Hummel, O. and Lee, Y.A. and Paskas, S. and Rintisch, C. and Saar, K. and Cooper, J. and Buchan, R. and Gray, E.E. and Cyster, J.G. and Braund, P. and Gracey, J. and Krishnan, U. and Moore, J.S. and Nelson, C.P. and Pollard, H. and Attwood, T. and Crisp-Hihn, A. and Foad, N. and Jolley, J. and Lloyd-Jones, H. and Muir, D. and Murray, E. and O'Leary, K. and Rankin, A. and Sambrook, J. and Godfroy, T. and Brocheton, J. and Proust, C. and Schmitz, G. and Heimerl, S. and Lugauer, I. and Belz, S. and Gulde, S. and Linsel-Nitschke, P. and Sager, H. and Schroeder, L. and Lundmark, P. and Syvannen, A.C. and Neudert, J. and Scholz, M. and Deloukas, P. and Gray, E. and Gwilliams, R. and Niblett, D. and Erdmann, J. and Hengstenberg, C. and Maouche, S. and Ouwehand, W.H. and Rice, C.M. and Samani, N.J. and Schunkert, H. and Goodall, A.H. and Schulz, H. and Roider, H.G. and Vingron, M. and Blankenberg, S. and Muenzel, T. and Zeller, T. and Szymczak, S. and Ziegler, A. and Tiret, L. and Smyth, D.J. and Pravenec, M. and Aitman, T.J. and Cambien, F. and Clayton, D. and Todd, J.A. and Huebner, N. and Cook, S.A.
Nature 467 (7314): 460-464. 23 September 2010

Wnt11 patterns a myocardial electrical gradient through regulation of the L-type Ca(2+) channel.
Panakova, D. and Werdich, A.A. and Macrae, C.A.
Nature 466 (7308): 874-878. 12 August 2010

Loss of fish actinotrichia proteins and the fin-to-limb transition.
Zhang, J. and Wagh, P. and Guay, D. and Sanchez-Pulido, L. and Padhi, B.K. and Korzh, V. and Andrade-Navarro, M.A. and Akimenko, M.A.
Nature 466 (7303): 234-237. 8 July 2010

Developmental sensory experience balances cortical excitation and inhibition.
Dorrn, A.L. and Yuan, K. and Barker, A.J. and Schreiner, C.E. and Froemke, R.C.
Nature 465 (7300): 932-936. 17 June 2010

Structural basis of oligomerization in the stalk region of dynamin-like MxA.
Gao, S. and von der Malsburg, A. and Paeschke, S. and Behlke, J. and Haller, O. and Kochs, G. and Daumke, O.
Nature 465 (7297): 502-506. 27 May 2010

Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis.
Sawamiphak, S. and Seidel, S. and Essmann, C.L. and Wilkinson, G.A. and Pitulescu, M.E. and Acker, T. and Acker-Palmer, A.
Nature 465 (7297): 487-491. 27 May 2010

The genome of a songbird.
Warren, W.C. and Clayton, D.F. and Ellegren, H. and Arnold, A.P. and Hillier, L.W. and Kuenstner, A. and Searle, S. and White, S. and Vilella, A.J. and Fairley, S. and Heger, A. and Kong, L. and Ponting, C.P. and Jarvis, E.D. and Mello, C.V. and Minx, P. and Lovell, P. and Velho, T.A. and Ferris, M. and Balakrishnan, C.N. and Sinha, S. and Blatti, C. and London, S.E. and Li, Y. and Lin, Y.C. and George, J. and Sweedler, J. and Southey, B. and Gunaratne, P. and Watson, M. and Nam, K. and Backstroem, N. and Smeds, L. and Nabholz, B. and Itoh, Y. and Whitney, O. and Pfenning, A.R. and Howard, J. and Voelker, M. and Skinner, B.M. and Griffin, D.K. and Ye, L. and McLaren, W.M. and Flicek, P. and Quesada, V. and Velasco, G. and Lopez-Otin, C. and Puente, X.S. and Olender, T. and Lancet, D. and Smit, A.F. and Hubley, R. and Konkel, M.K. and Walker, J.A. and Batzer, M.A. and Gu, W. and Pollock, D.D. and Chen, L. and Cheng, Z. and Eichler, E.E. and Stapley, J. and Slate, J. and Ekblom, R. and Birkhead, T. and Burke, T. and Burt, D. and Scharff, C. and Adam, I. and Richard, H. and Sultan, M. and Soldatov, A. and Lehrach, H. and Edwards, S.V. and Yang, S.P. and Li, X. and Graves, T. and Fulton, L. and Nelson, J. and Chinwalla, A. and Hou, S. and Mardis, E.R. and Wilson, R.K.
Nature 464 (7289): 757-762. 1 April 2010

Ancient animal microRNAs and the evolution of tissue identity.
Christodoulou, F. and Raible, F. and Tomer, R. and Simakov, O. and Trachana, K. and Klaus, S. and Snyman, H. and Hannon, G.J. and Bork, P. and Arendt, D.
Nature 463 (7284): 1084-1088. 25 February 2010

2009

Central control of fever and female body temperature by RANKL/RANK.
Hanada, R. and Leibbrandt, A. and Hanada, T. and Kitaoka, S. and Furuyashiki, T. and Fujihara, H. and Trichereau, J. and Paolino, M. and Qadri, F. and Plehm, R. and Klaere, S. and Komnenovic, V. and Mimata, H. and Yoshimatsu, H. and Takahashi, N. and von Haeseler, A. and Bader, M. and Kilic, S.S. and Ueta, Y. and Pifl, C. and Narumiya, S. and Penninger, J.M.
Nature 462 (7272): 505-509. 26 November 2009

Combinatorial binding predicts spatio-temporal cis-regulatory activity.
Zinzen, R.P. and Girardot, C. and Gagneur, J. and Braun, M. and Furlong, E.E.
Nature 462 (7269): 65-70. 5 November 2009

CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia.
Buonamici, S. and Trimarchi, T. and Ruocco, M.G. and Reavie, L. and Cathelin, S. and Mar, B.G. and Klinakis, A. and Lukyanov, Y. and Tseng, J.C. and Sen, F. and Gehrie, E. and Li, M. and Newcomb, E. and Zavadil, J. and Meruelo, D. and Lipp, M. and Ibrahim, S. and Efstratiadis, A. and Zagzag, D. and Bromberg, J.S. and Dustin, M.L. and Aifantis, I.
Nature 459 (7249): 1000-1004. 18 June 2009

Clustering of InsP3 receptors by InsP3 retunes their regulation by InsP3 and Ca2+.
Taufiq-Ur-Rahman, and Skupin, A. and Falcke, M. and Taylor, C.W.
Nature 458 (7238): 655-659. 2 April 2009

The ubiquitylation machinery of the endoplasmic reticulum.
Hirsch, C. and Gauss, R. and Horn, S.C. and Neuber, O. and Sommer, T.
Nature 458 (7237): 453-460. 26 March 2009

2008

The genome of the simian and human malaria parasite Plasmodium knowlesi.
Pain, A. and Boehme, U. and Berry, A.E. and Mungall, K. and Finn, R.D. and Jackson, A.P. and Mourier, T. and Mistry, J. and Pasini, E.M. and Aslett, M.A. and Balasubrammaniam, S. and Borgwardt, K. and Brooks, K. and Carret, C. and Carver, T.J. and Cherevach, I. and Chillingworth, T. and Clark, T.G. and Galinski, M.R. and Hall, N. and Harper, D. and Harris, D. and Hauser, H. and Ivens, A. and Janssen, C.S. and Keane, T. and Larke, N. and Lapp, S. and Marti, M. and Moule, S. and Meyer, I.M. and Ormond, D. and Peters, N. and Sanders, M. and Sanders, S. and Sargeant, T.J. and Simmonds, M. and Smith, F. and Squares, R. and Thurston, S. and Tivey, A.R. and Walker, D. and White, B. and Zuiderwijk, E. and Churcher, C. and Quail, M.A. and Cowman, A.F. and Turner, C.M.R. and Rajandream, MA and Kocken, C.H.M. and Thomas, A.W. and Newbold, C.I. and Barrell, B.G. and Berriman, M.
Nature 455 (7214): 799-803. 9 October 2008

Widespread changes in protein synthesis induced by microRNAs.
Selbach, M. and Schwanhaeusser, B. and Thierfelder, N. and Fang, Z. and Khanin, R. and Rajewsky, N.
Nature 455 (7209): 58-63. 4 September 2008

Internal brain state regulates membrane potential synchrony in barrel cortex of behaving mice.
Poulet, J.F.A. and Petersen, C.C.
Nature 454 (7206): 881-885. 14 August 2008

Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migration.
Graupera, M. and Guillermet-Guibert, J. and Foukas, L.C. and Phng, L.K. and Cain, R.J. and Salpekar, A. and Pearce, W. and Meek, S. and Millan, J. and Cutillas, P.R. and Smith, A.J.H. and Ridley, A.J. and Ruhrberg, C. and Gerhardt, H. and Vanhaesebroeck, B.
Nature 453 (7195): 662-666. 29 May 2008

Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population.
Yang, L. and Soonpaa, M.H. and Adler, E.D. and Roepke, T.K. and Kattman, S.J. and Kennedy, M. and Henckaerts, E. and Bonham, K. and Abbott, G.W. and Linden, R.M. and Field, L.J. and Keller, G.M.
Nature 453 (7194): 524-528. 22 May 2008

The genome of the model beetle and pest tribolium castaneum.

Nature 452 (7190): 949-955. 24 April 2008

Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling.
Malanchi, I. and Peinado, H. and Kassen, D. and Hussenet, T. and Metzger, D. and Chambon, P. and Huber, M. and Hohl, D. and Cano, A. and Birchmeier, W. and Huelsken, J.
Nature 452 (7187): 650-653. 3 April 2008

The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans.
King, N. and Westbrook, M.J. and Young, S.L. and Kuo, A. and Abedin, M. and Chapman, J. and Fairclough, S. and Hellsten, U. and Isogai, Y. and Letunic, I. and Marr, M. and Pincus, D. and Putnam, N. and Rokas, A. and Wright, K.J. and Zuzow, R. and Dirks, W. and Good, M. and Goodstein, D. and Lemons, D. and Li, W. and Lyons, J.B. and Morris, A. and Nichols, S. and Richter, D.J. and Salamov, A. and Sequencing, J.G.I. and Bork, P. and Lim, W.A. and Manning, G. and Miller, W.T. and McGinnis, W. and Shapiro, H. and Tjian, R. and Grigoriev, I.V. and Rokhsar, D.
Nature 451 (7180): 783-788. 14 February 2008

2007

A viral microRNA functions as an orthologue of cellular miR-155.
Gottwein, E. and Mukherjee, N. and Sachse, C. and Frenzel, C. and Majoros, W.H. and Chi, J.T.A. and Braich, R. and Manoharan, M. and Soutschek, J. and Ohler, U. and Cullen, B.R.
Nature 450 (7172): 1096-1099. 13 December 2007

Helicobacter exploits integrin for type IV secretion and kinase activation.
Kwok, T. and Zabler, D. and Urman, S. and Rohde, M. and Hartig, R. and Wessler, S. and Misselwitz, R. and Berger, J.M. and Sewald, N. and Koenig, W. and Backert, S.
Nature 449 (7164): 862-866. 18 October 2007

Architectural and mechanistic insights into an EHD ATPase involved in membrane remodelling.
Daumke, O. and Lundmark, R. and Vallis, Y. and Martens, S. and Butler, P.J.G. and McMahon, H.T.
Nature 449 (7164): 923-927. 3 October 2007

The menthol receptor TRPM8 is the principal detector of environmental cold.
Bautista, D.M. and Siemens, J. and Glazer, J.M. and Tsuruda, P.R. and Basbaum, A.I. and Stucky, C.L. and Jordt, S.E. and Julius, D.
Nature 448 (7150): 204-208. 12 July 2007

The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks.
Kruhlak, M. and Crouch, E.E. and Orlov, M. and Montaño, C. and Gorski, S.A. and Nussenzweig, A. and Misteli, T. and Phair, R.D. and Casellas, R.
Nature 447 (7145): 730-734. 7 June 2007

Neuroscience: The brain's garbage men.
Kettenmann, H.
Nature 446 (7139): 987-989. 26 April 2007

Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis.
Hellström, M. and Phng, L.K. and Hofmann, J.J. and Wallgard, E. and Coultas, L. and Lindblom, P. and Alva, J. and Nilsson, A.K. and Karlsson, L. and Gaiano, N. and Yoon, K. and Rossant, J. and Iruela-Arispe, M.L. and Kalén, M. and Gerhardt, H. and Betsholtz, C.
Nature 445 (7129): 776-780. 15 February 2007

A stomatin-domain protein essential for touch sensation in the mouse.
Wetzel, C. and Hu, J. and Riethmacher, D. and Benckendorff, A. and Harder, L. and Eilers, A. and Moshourab, R. and Kozlenkov, A. and Labuz, D. and Caspani, O. and Erdmann, B. and Machelska, H. and Heppenstall, P.A. and Lewin, G.R.
Nature 445 (7124): 206-209. 11 January 2007

2006

Spider toxins activate the capsaicin receptor to produce inflammatory pain.
Siemens, J.E. and Zhou, S. and Piskorowski, R. and Nikai, T. and Lumpkin, E.A. and Basbaum, A.I. and King, D. and Julius, D.
Nature 444 (7116): 208-212. 9 November 2006

Insights into social insects from the genome of the honeybee Apis mellifera.

Nature 443 (7114): 931-949. 26 October 2006

Co-evolution of transcriptional and post-translational cell-cycle regulation.
Jensen, L.J. and Jensen, T.S. and de Lichtenberg, U. and Brunak, S. and Bork, P.
Nature 443 (7111): 594-597. 4 October 2006

Hungary's 'reforms' are threatening basic science.
Izsvak, Z. and Ivics, Z. and Mates, L.
Nature 443 (7110): 394. 28 September 2006

Proteome survey reveals modularity of the yeast cell machinery.
Gavin, A.C. and Aloy, P. and Grandi, P. and Krause, R. and Boesche, M. and Marzioch, M. and Rau, C. and Jensen, L.J. and Bastuck, S. and Duempelfeld, B. and Edelmann, A. and Heurtier, M.A. and Hoffman, V. and Hoefert, C. and Klein, K. and Hudak, M. and Michon, A.M. and Schelder, M. and Schirle, M. and Remor, M. and Rudi, T. and Hooper, S. and Bauer, A. and Bouwmeester, T. and Casari, G. and Drewes, G. and Neubauer, G. and Rick, J.M. and Kuster, B. and Bork, P. and Russell, R.B. and Superti-Furga, G.
Nature 440 (7084): 631-636. 30 March 2006

Robust Salmonella metabolism limits possibilities for new antimicrobials.
Becker, D. and Selbach, M. and Rollenhagen, C. and Ballmaier, M. and Meyer, T.F. and Mann, M. and Bumann, D.
Nature 440 (7082): 303-307. 16 March 2006

ClC-7 requires Ostm1 as a beta-subunit to support bone resorption and lysosomal function.
Lange, P.F. and Wartosch, L. and Jentsch, T.J. and Fuhrmann, J.C.
Nature 440 (7081): 220-223. 9 March 2006

2005

Silencing of microRNAs in vivo with 'antagomirs'.
Krutzfeldt, J. and Rajewsky, N. and Braich, R. and Rajeev, K.G. and Tuschl, T. and Manoharan, M. and Stoffel, M.
Nature 438 (7068): 685-689. 1 December 2005

Initial sequence of the chimpanzee genome and comparison with the human genome.
Mikkelsen, T.S. and Hillier, L.W. and Eichler, E.E. and Zody, M.C. and Jaffe, D.B. and Yang, S.P. and Enard, W. and Hellmann, I. and Lindblad-Toh, K. and Altheide, T.K. and Archidiacono, N. and Bork, P. and Butler, J. and Chang, J.L. and Cheng, Z. and Chinwalla, A.T. and de Jong, P. and Delehaunty, K.D. and Fronick, C.C. and Fulton, L.L. and Gilad, Y. and Glusman, G. and Gnerre, S. and Graves, T.A. and Hayakawa, T. and Hayden, K.E. and Huang, X.Q. and Ji, H.K. and Kent, W.J. and King, M.C. and Kulbokas, E.J. and Lee, M.K. and Liu, G. and Lopez-Otin, C. and Makova, K.D. and Man, O. and Mardis, E.R. and Mauceli, E. and Miner, T.L. and Nash, W.E. and Nelson, J.O. and Paeaebo, S. and Patterson, N.J. and Pohl, C.S. and Pollard, K.S. and Pruefer, K. and Puente, X.S. and Reich, D. and Rocchi, M. and Rosenbloom, K. and Ruvolo, M. and Richter, D.J. and Schaffner, S.F. and Smit, A.F.A. and Smith, S.M. and Suyama, M. and Taylor, J. and Torrents, D. and Tuzun, E. and Varki, A. and Velasco, G. and Ventura, M. and Wallis, J.W. and Wendl, M.C. and Wilson, R.K. and Lander, E.S. and Waterston, R.H.
Nature 437 (7055): 69-87. 1 September 2005

Sporadic immunogenic tumours avoid destruction by inducing T-cell tolerance.
Willimsky, G. and Blankenstein, T.
Nature 437 (7055): 141-146. 1 September 2005

Oncogene-induced senescence as an initial barrier in lymphoma development.
Braig, M. and Lee, S. and Loddenkemper, C. and Rudolph, C. and Peters, A.H. and Schlegelberger, B. and Stein, H. and Doerken, B. and Jenuwein, T. and Schmitt, C.A.
Nature 436 (7051): 660-665. 4 August 2005

Voltage-dependent electrogenic chloride/proton exchange by endosomal CLC proteins.
Scheel, O. and Zdebik, A.A. and Lourdel, S. and Jentsch, T.J.
Nature 436 (7049): 424-427. 21 July 2005

Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
Hillier, L.W. and Graves, T.A. and Fulton, R.S. and Fulton, L.A. and Pepin, K.H. and Minx, P. and Wagner-McPherson, C. and Layman, D. and Wylie, K. and Sekhon, M. and Becker, M.C. and Fewell, G.A. and Delehaunty, K.D. and Miner, T.L. and Nash, W.E. and Kremitzki, C. and Oddy, L. and Du, H. and Sun, H. and Bradshaw-Cordum, H. and Ali, J. and Carter, J. and Cordes, M. and Harris, A. and Isak, A. and van Brunt, A. and Nguyen, C. and Du, F. and Courtney, L. and Kalicki, J. and Ozersky, P. and Abbott, S. and Armstrong, J. and Belter, E.A. and Caruso, L. and Cedroni, M. and Cotton, M. and Davidson, T. and Desai, A. and Elliott, G. and Erb, T. and Fronick, C. and Gaige, T. and Haakenson, W. and Haglund, K. and Holmes, A. and Harkins, R. and Kim, K. and Kruchowski, S.S. and Strong, C.M. and Grewal, N. and Goyea, E. and Hou, S. and Levy, A. and Martinka, S. and Mead, K. and McLellan, M.D. and Meyer, R. and Randall-Maher, J. and Tomlinson, C. and uphin-Kohlberg, S. and Kozlowicz-Reilly, A. and Shah, N. and Swearengen-Shahid, S. and Snider, J. and Strong, J.T. and Thompson, J. and Yoakum, M. and Leonard, S. and Pearman, C. and Trani, L. and Radionenko, M. and Waligorski, J.E. and Wang, C. and Rock, S.M. and Tin-Wollam, A.M. and Maupin, R. and Latreille, P. and Wendl, M.C. and Yang, S.P. and Pohl, C. and Wallis, J.W. and Spieth, J. and Bieri, T.A. and Berkowicz, N. and Nelson, J.O. and Osborne, J. and Ding, L. and Meyer, R. and Sabo, A. and Shotland, Y. and Sinha, P. and Wohldmann, P.E. and Cook, L.L. and Hickenbotham, M.T. and Eldred, J. and Williams, D. and Jones, T.A. and She, X. and Ciccarelli, F.D. and Izaurralde, E. and Taylor, J. and Schmutz, J. and Myers, R.M. and Cox, D.R. and Huang, X. and McPherson, J.D. and Mardis, E.R. and Clifton, S.W. and Warren, W.C. and Chinwalla, A.T. and Eddy, S.R. and Marra, M.A. and Ovcharenko, I. and Furey, T.S. and Miller, W. and Eichler, E.E. and Bork, P. and Suyama, M. and Torrents, D. and Waterston, R.H. and Wilson, R.K.
Nature 434 : 724-731. 1 January 2005

2004

Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution.
Hillier, L.W. and Miller, W. and Birney, E. and Warren, W. and Hardison, R.C. and Ponting, C.P. and Bork, P. and Burt, D.W. and Groenen, M.A.M. and Delany, M.E. and Dodgson, J.B. and Chinwalla, A.T. and Cliften, P.F. and Clifton, S.W. and Delehaunty, K.D. and Fronick, C. and Fulton, R.S. and Graves, T.A. and Kremitzki, C. and Layman, D. and Magrini, V. and McPherson, J.D. and Miner, T.L. and Minx, P. and Nash, W.E. and Nhan, M.N. and Nelson, J.O. and Oddy, L.G. and Pohl, C.S. and Randall-Maher, J. and Smith, S.M. and Wallis, J.W. and Yang, S.P. and Romanov, M.N. and Rondelli, C.M. and Paton, B. and Smith, J. and Morrice, D. and Daniels, L. and Tempest, H.G. and Robertson, L. and Masabanda, J.S. and Griffin, D.K. and Vignal, A. and Fillon, V. and Jacobbson, L. and Kerje, S. and Andersson, L. and Crooijmans, R.P.M. and Aerts, J. and van der Poel, J.J. and Ellegren, H. and Caldwell, R.B. and Hubbard, S.J. and Grafham, D.V. and Kierzek, A.M. and McLaren, S.R. and Overton, I.M. and Arakawa, H. and Beattie, K.J. and Bezzubov, Y. and Boardman, P.E. and Bonfield, J.K. and Croning, M.D.R. and Davies, R.M. and Francis, M.D. and Humphray, S.J. and Scott, C.E. and Taylor, R.G. and Tickle, C. and Brown, W.R.A. and Rogers, J. and Buerstedde, J.M. and Wilson, S.A. and Stubbs, L. and Ovcharenko, I. and Gordon, L. and Lucas, S. and Miller, M.M. and Inoko, H. and Shiina, T. and Kaufman, J. and Salomonsen, J. and Skjoedt, K. and Wong, G.K.S. and Wang, J. and Liu, B. and Wang, J. and Yu, J. and Yang, H.M. and Nefedov, M. and Koriabine, M. and de Jong, P.J. and Goodstadt, L. and Webber, C. and Dickens, N.J. and Letunic, I. and Suyama, M. and Torrents, D. and von Mering, C. and Zdobnov, E.M. and Makova, K. and Nekrutenko, A. and Elnitski, L. and Eswara, P. and King, D.C. and Yang, S. and Tyekucheva, S. and Radakrishnan, A. and Harris, R.S. and Chiaromonte, F. and Taylor, J. and He, J.B. and Rijnkels, M. and Griffiths-Jones, S. and Ureta-Vidal, A. and Hoffman, M.M. and Severin, J. and Searle, S.M.J. and Law, A.S. and Speed, D. and Waddington, D. and Cheng, Z. and Tuzun, E. and Eichler, E. and Bao, Z.R. and Flicek, P. and Shteynberg, D.D. and Brent, M.R. and Bye, J.M. and Huckle, E.J. and Chatterji, S. and Dewey, C. and Pachter, L. and Kouranov, A. and Mourelatos, Z. and Hatzigeorgiou, A.G. and Paterson, A.H. and Ivarie, R. and Brandstrom, M. and Axelsson, E. and Backstrom, N. and Berlin, S. and Webster, M.T. and Pourquie, O. and Reymond, A. and Ucla, C. and Antonarakis, S.E. and Long, M.Y. and Emerson, J.J. and Betran, E. and Dupanloup, I. and Kaessmann, H. and Hinrichs, A.S. and Bejerano, G. and Furey, T.S. and Harte, R.A. and Raney, B. and Siepel, A. and Kent, W.J. and Haussler, D. and Eyras, E. and Castelo, R. and Abril, J.F. and Castellano, S. and Camara, F. and Parra, G. and Guigo, R. and Bourque, G. and Tesler, G. and Pevzner, P.A. and Smit, A. and Fulton, L.A. and Mardis, E.R. and Wilson, R.K.
Nature 432 (7018): 695-716. 9 December 2004

The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system.
Lu, X. and le Noble, F. and Yuan, L. and Jiang, Q. and de Lafarge, B. and Sugiyama, D. and Breant, C. and Claes, F. and de Smet, F. and Thomas, J.L. and Autiero, M. and Carmeliet, P. and Tessier-Lavigne, M. and Eichmann, A.
Nature 432 (7014): 179-186. 11 November 2004

A pancreatic islet-specific microRNA regulates insulin secretion.
Poy, M.N. and Eliasson, L. and Krutzfeldt, J. and Kuwajima, S. and Ma, X. and Macdonald, P.E. and Pfeffer, S. and Tuschl, T. and Rajewsky, N. and Rorsman, P. and Stoffel, M.
Nature 432 (7014): 226-230. 11 November 2004

Complex auditory behaviour emerges from simple reactive steering.
Hedwig, B. and Poulet, J.F.A.
Nature 430 (7001): 781-785. 12 August 2004

The GTPase-activating protein Rap1GAP uses a catalytic asparagine.
Daumke, O. and Weyand, M. and Chakrabarti, P.P. and Vetter, I.R. and Wittinghofer, A.
Nature 429 (6988): 197-201. 13 May 2004

Cadherin 23 is a component of the tip link in hair-cell stereocilia.
Siemens, J. and Lillo, C. and Dumont, R.A. and Reynolds, A. and Williams, D.S. and Gillespie, P.G. and Mueller, U.
Nature 428 (6986): 950-955. 29 April 2004

Mutations in cadherin 23 affect tip links in zebrafish sensory hair cells.
Soellner, C. and Rauch, G.J. and Siemens, J. and Geisler, R. and Schuster, S.C. and Mueller, U. and Nicolson, T.
Nature 428 (6986): 955-959. 29 April 2004

Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs, R.A. and Weinstock, G.M. and Metzker, M.L. and Muzny, D.M. and Sodergren, E.J. and Scherer, S. and Scott, G. and Steffen, D. and Worley, K.C. and Burch, P.E. and Okwuonu, G. and Hines, S. and Lewis, L. and DeRamo, C. and Delgado, O. and Dugan-Rocha, S. and Miner, G. and Morgan, M. and Hawes, A. and Gill, R. and Holt, R.A. and Adams, M.D. and Amanatides, P.G. and Baden-Tillson, H. and Barnstead, M. and Chin, S. and Evans, C.A. and Ferriera, S. and Fosler, C. and Glodek, A. and Gu, Z. and Jennings, D. and Kraft, C.L. and Nguyen, T. and Pfannkoch, C.M. and Sitter, C. and Sutton, G.G. and Venter, J.C. and Woodage, T. and Smith, D. and Lee, H.M. and Gustafson, E. and Cahill, P. and Kana, A. and Doucette-Stamm, L. and Weinstock, K. and Fechtel, K. and Weiss, R.B. and Dunn, D.M. and Green, E.D. and Blakesley, R.W. and Bouffard, G.G. and de Jong, P.J. and Osoegawa, K. and Zhu, B. and Marra, M. and Schein, J. and Bosdet, I. and Fjell, C. and Jones, S. and Krzywinski, M. and Mathewson, C. and Siddiqui, A. and Wye, N. and McPherson, J. and Zhao, S. and Fraser, C.M. and Shetty, J. and Shatsman, S. and Geer, K. and Chen, Y. and Abramzon, S. and Nierman, W.C. and Havlak, P.H. and Chen, R. and Durbin, K.J. and Egan, A. and Ren, Y. and Song, X.Z. and Li, B. and Liu, Y. and Qin, X. and Cawley, S. and Worley, K.C. and Cooney, A.J. and D'Souza, L.M. and Martin, K. and Wu, J.Q. and Gonzalez-Garay, M.L. and Jackson, A.R. and Kalafus, K.J. and McLeod, M.P. and Milosavljevic, A. and Virk, D. and Volkov, A. and Wheeler, D.A. and Zhang, Z. and Bailey, J.A. and Eichler, E.E. and Tuzun, E. and Birney, E. and Mongin, E. and Ureta-Vidal, A. and Woodwark, C. and Zdobnov, E. and Bork, P. and Suyama, M. and Torrents, D. and Alexandersson, M. and Trask, B.J. and Young, J.M. and Huang, H. and Wang, H. and Xing, H. and Daniels, S. and Gietzen, D. and Schmidt, J. and Stevens, K. and Vitt, U. and Wingrove, J. and Camara, F. and Alba, M.M. and Abril, J.F. and Guigo, R. and Smit, A. and Dubchak, I. and Rubin, E.M. and Couronne, O. and Poliakov, A. and Hübner, N. and Ganten, D. and Goesele, C. and Hummel, O. and Kreitler, T. and Lee, Y.A. and Monti, J. and Schulz, H. and Zimdahl, H. and Himmelbauer, H. and Lehrach, H. and Jacob, H.J. and Bromberg, S. and Gullings-Handley, J. and Jensen-Seaman, M.I. and Kwitek, A.E. and Lazar, J. and Pasko, D. and Tonellato, P.J. and Twigger, S. and Ponting, C.P. and Duarte, J.M. and Rice, S. and Goodstadt, L. and Beatson, S.A. and Emes, R.D. and Winter, E.E. and Webber, C. and Brandt, P. and Nyakatura, G. and Adetobi, M. and Chiaromonte, F. and Elnitski, L. and Eswara, P. and Hardison, R.C. and Hou, M. and Kolbe, D. and Makova, K. and Miller, W. and Nekrutenko, A. and Riemer, C. and Schwartz, S. and Taylor, J. and Yang, S. and Zhang, Y. and Lindpaintner, K. and Andrews, T.D. and Caccamo, M. and Clamp, M. and Clarke, L. and Curwen, V. and Durbin, R. and Eyras, E. and Searle, S.M. and Cooper, G.M. and Batzoglou, S. and Brudno, M. and Sidow, A. and Stone, E.A. and Venter, J.C. and Payseur, B.A. and Bourque, G. and Lopez-Otin, C. and Puente, X.S. and Chakrabarti, K. and Chatterji, S. and Dewey, C. and Pachter, L. and Bray, N. and Yap, V.B. and Caspi, A. and Tesler, G. and Pevzner, P.A. and Haussler, D. and Roskin, K.M. and Baertsch, R. and Clawson, H. and Furey, T.S. and Hinrichs, A.S. and Karolchik, D. and Kent, W.J. and Rosenbloom, K.R. and Trumbower, H. and Weirauch, M. and Cooper, D.N. and Stenson, P.D. and Ma, B. and Brent, M. and Arumugam, M. and Shteynberg, D. and Copley, R.R. and Taylor, M.S. and Riethman, H. and Mudunuri, U. and Peterson, J. and Guyer, M. and Felsenfeld, A. and Old, S. and Mockrin, S. and Collins, F.
Nature 428 (6982): 493-521. 1 April 2004

Sortilin is essential for proNGF-induced neuronal cell death.
Nykjaer, A. and Lee, R. and Teng, K.K. and Jansen, P. and Madsen, P. and Nielsen, M.S. and Jacobsen, C. and Kliemannel, M. and Schwarz, E. and Willnow, T.E. and Hempstead, B.L. and Petersen, C.M.
Nature 427 (6977): 843-848. 26 February 2004

2003

Positioning of follicular dendritic cells within the spleen controls prion neuroinvasion.
Prinz, M. and Heikenwalder, M. and Junt, T. and Schwarz, P. and Glatzel, M. and Heppner, F.L. and Fu, Y.X. and Lipp, M. and Aguzzi, A.
Nature 425 (6961): 957-962. 30 October 2003

The DNA sequence of human chromosome 7.
Hillier, L.W. and Fulton, R.S. and Fulton, L.A. and Graves, T.A. and Pepin, K.H. and Wagner-McPherson, C. and Layman, D. and Maas, J. and Jaeger, S. and Walker, R. and Wylie, K. and Sekhon, M. and Becker, M.C. and O'Laughlin, M.D. and Schaller, M.E. and Fewell, G.A. and Delehaunty, K.D. and Miner, T.L. and Nash, W.E. and Cordes, M. and Du, H. and Sun, H. and Edwards, J. and Bradshaw-Cordum, H. and Ali, J. and Andrews, S. and Isak, A. and VanBrunt, A. and Nguyen, C. and Du, F.Y. and Lamar, B. and Courtney, L. and Kalicki, J. and Ozersky, P. and Bielicki, L. and Scott, K. and Holmes, A. and Harkins, R. and Harris, A. and Strong, C.M. and Hou, S.F. and Tomlinson, C. and Dauphin-Kohlberg, S. and Kozlowicz-Reilly, A. and Leonard, S. and Rohlfing, T. and Rock, S.M. and Tin-Wollam, A.M. and Abbott, A. and Minx, P. and Maupin, R. and Strowmatt, C. and Latreille, P. and Miller, N. and Johnson, D. and Murray, J. and Woessner, J.P. and Wendl, M.C. and Yang, S.P. and Schultz, B.R. and Wallis, J.W. and Spieth, J. and Bieri, T.A. and Nelson, J.O. and Berkowicz, N. and Wohldmann, P.E. and Cook, L.L. and Hickenbotham, M.T. and Eldred, J. and Williams, D. and Bedell, J.A. and Mardis, E.R. and Clifton, S.W. and Chissoe, S.L. and Marra, M.A. and Raymond, C. and Haugen, E. and Gillett, W. and Zhou, Y. and James, R. and Phelps, K. and Iadanoto, S. and Bubb, K. and Simms, E. and Levy, R. and Clendenning, J. and Kaul, R. and Kent, W.J. and Furey, T.S. and Baertsch, R.A. and Brent, M.R. and Keibler, E. and Flicek, P. and Bork, P. and Suyama, M. and Bailey, J.A. and Portnoy, M.E. and Torrents, D. and Chinwalla, A.T. and Gish, W.R. and Eddy, S.R. and McPherson, J.D. and Olson, M.V. and Eichler, E.E. and Green, E.D. and Waterston, R.H. and Wilson, R.K.
Nature 424 : 157-164. 1 January 2003

2002

Initial sequencing and comparative analysis of the mouse genome.
Waterston, R.H. and Lindblad-Toh, K. and Birney, E. and Rogers, J. and Abril, J.F. and Agarwal, P. and Agarwala, R. and Ainscough, R. and Alexandersson, M. and An, P. and Antonarakis, S.E. and Attwood, J. and Baertsch, R. and Bailey, J. and Barlow, K. and Beck, S. and Berry, E. and Birren, B. and Bloom, T. and Bork, P. and Botcherby, M. and Bray, N. and Brent, M.R. and Brown, D.G. and Brown, S.D. and Bult, C. and Burton, J. and Butler, J. and Campbell, R.D. and Carninci, P. and Cawley, S. and Chiaromonte, F. and Chinwalla, A.T. and Church, D.M. and Clamp, M. and Clee, C. and Collins, F.S. and Cook, L.L. and Copley, R.R. and Coulson, A. and Couronne, O. and Cuff, J. and Curwen, V. and Cutts, T. and Daly, M. and David, R. and Davies, J. and Delehaunty, K.D. and Deri, J. and Dermitzakis, E.T. and Dewey, C. and Dickens, N.J. and Diekhans, M. and Dodge, S. and Dubchak, I. and Dunn, D.M. and Eddy, S.R. and Elnitski, L. and Emes, R.D. and Eswara, P. and Eyras, E. and Felsenfeld, A. and Fewell, G.A. and Flicek, P. and Foley, K. and Frankel, W.N. and Fulton, L.A. and Fulton, R.S. and Furey, T.S. and Gage, D. and Gibbs, R.A. and Glusman, G. and Gnerre, S. and Goldman, N. and Goodstadt, L. and Grafham, D. and Graves, T.A. and Green, E.D. and Gregory, S. and Guigo, R. and Guyer, M. and Hardison, R.C. and Haussler, D. and Hayashizaki, Y. and Hillier, L.W. and Hinrichs, A. and Hlavina, W. and Holzer, T. and Hsu, F. and Hua, A. and Hubbard, T. and Hunt, A. and Jackson, I. and Jaffe, D.B. and Johnson, L.S. and Jones, M. and Jones, T.A. and Joy, A. and Kamal, M. and Karlsson, E.K. and Karolchik, D. and Kasprzyk, A. and Kawai, J. and Keibler, E. and Kells, C. and Kent, W.J. and Kirby, A. and Kolbe, D.L. and Korf, I. and Kucherlapati, R.S. and Kulbokas, E.J. and Kulp, D. and Landers, T. and Leger, J.P. and Leonard, S. and Letunic, I. and LeVine, R. and Li, J. and Li, M. and Lloyd, C. and Lucas, S. and Ma, B. and Maglott, D.R. and Mardis, E.R. and Matthews, L. and Mauceli, E. and Mayer, J.H. and McCarthy, M. and McCombie, W.R. and McLaren, S. and McLay, K. and McPherson, J.D. and Meldrim, J. and Meredith, B. and Mesirov, J.P. and Miller, W. and Miner, T.L. and Mongin, E. and Montgomery, K.T. and Morgan, M. and Mott, R. and Mullikin, J.C. and Muzny, D.M. and Nash, W.E. and Nelson, J.O. and Nhan, M.N. and Nicol, R. and Ning, Z. and Nusbaum, C. and O'Connor, M.J. and Okazaki, Y. and Oliver, K. and Overton-Larty, E. and Pachter, L. and Parra, G. and Pepin, K.H. and Peterson, J. and Pevzner, P. and Plumb, R. and Pohl, C.S. and Poliakov, A. and Ponce, T.C. and Ponting, C.P. and Potter, S. and Quail, M. and Reymond, A. and Roe, B.A. and Roskin, K.M. and Rubin, E.M. and Rust, A.G. and Santos, R. and Sapojnikov, V. and Schultz, B. and Schultz, J. and Schwartz, M.S. and Schwartz, S. and Scott, C. and Seaman, S. and Searle, S. and Sharpe, T. and Sheridan, A. and Shownkeen, R. and Sims, S. and Singer, J.B. and Slater, G. and Smit, A. and Smith, D.R. and Spencer, B. and Stabenau, A. and Stange-Thomann, N. and Sugnet, C. and Suyama, M. and Tesler, G. and Thompson, J. and Torrents, D. and Trevaskis, E. and Tromp, J. and Ucla, C. and Ureta-Vidal, A. and Vinson, J.P. and von Niederhausern, A.C. and Wade, C.M. and Wall, M. and Weber, R.J. and Weiss, R.B. and Wendl, M.C. and West, A.P. and Wetterstrand, K. and Wheeler, R. and Whelan, S. and Wierzbowski, J. and Willey, D. and Williams, S. and Wilson, R.K. and Winter, E. and Worley, K.C. and Wyman, D. and Yang, S. and Yang, S.P. and Zdobnov, E.M. and Zody, M.C. and Lander, E.S.
Nature 420 (6915): 520-562. 5 December 2002

Metabolic network structure determines key aspects of functionality and regulation.
Stelling, J. and Klamt, S. and Bettenbrock, K. and Schuster, S. and Gilles, E.D.
Nature 420 (6912): 190-193. 14 November 2002

A corollary discharge maintains auditory sensitivity during sound production.
Poulet, J.F.A. and Hedwig, B.
Nature 418 (6900): 872-876. 22 August 2002

Genome organization: Teamed up for transcription.
von Mering, C. and Bork, P.
Nature 417 (6891): 797-798. 20 June 2002

Comparative assessment of large-scale data sets of protein-protein interactions.
von Mering, C. and Krause, R. and Snel, B. and Cornell, M. and Oliver, S.G. and Fields, S. and Bork, P.
Nature 417 (6887): 399-403. 23 May 2002

Deafness and renal tubular acidosis in mice lacking the K-Cl co-transporter Kcc4.
Boettger, T. and Huebner, C.A. and Maier, H. and Rust, M.B. and Beck, F.X. and Jentsch, T.J.
Nature 416 (6883): 874-878. 25 April 2002

Chloride channels are different.
Jentsch, T.J.
Nature 415 (6869): 276-277. 17 January 2002

Functional organization of the yeast proteome by systematic analysis of protein complexes.
Gavin, A.C. and Boesche, M. and Krause, R. and Grandi, P. and Marzioch, M. and Bauer, A. and Schultz, J. and Rick, J.M. and Michon, A.M. and Cruciat, C.M. and Remor, M. and Hoefert, C. and Schelder, M. and Brajenovic, M. and Ruffner, H. and Merino, A. and Klein, K. and Hudak, M. and Dickson, D. and Rudi, T. and Gnau, V. and Bauch, A. and Bastuck, S. and Huhse, B. and Leutwein, C. and Heurtier, M.A. and Copley, R.R. and Edelmann, A. and Querfurth, E. and Rybin, V. and Drewes, G. and Raida, M. and Bouwmeester, T. and Bork, P. and Seraphin, B. and Kuester, B. and Neubauer, G. and Superti-Furga, G.
Nature 415 (6868): 141-147. 10 January 2002

Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position.
Reif, K. and Ekland, E.H. and Ohl, L. and Nakano, H. and Lipp, M. and Foerster, R. and Cyster, J.G.
Nature 416 : 94-99. 1 January 2002

2001

Barttin is a Cl- channel beta-subunit crucial for renal Cl- reabsorption and inner ear K+ secretion.
Estevez, R. and Boettger, T. and Stein, V. and Birkenhaeger, R. and Otto, E. and Hildebrandt, F. and Jentsch, T.J.
Nature 414 (6863): 558-561. 29 November 2001

Planned law could put German research at risk.
Jentsch, T.
Nature 413 (6858): 772. 25 October 2001

Hero or villain? Stasi archives shed light on russian scientist.
Hossfeld, U. and Walker, M.
Nature 411 (6835): 237. 17 May 2001

Skewed maturation of memory HIV-specific CD8 T lymphocytes.
Champagne, P. and Ogg, G.S. and King, A.S. and Knabenhans, C. and Ellefsen, K. and Nobile, M. and Appay, V. and Rizzardi, G.P. and Fleury, S. and Lipp, M. and Foerster, R. and Rowland-Jones, S. and Sekaly, R.P. and McMichael, A.J. and Pantaleo, G.
Nature 410 (6824): 106-111. 1 March 2001

The draft sequences. Filling in the gaps.
Bork, P. and Copley, R.
Nature 409 (6822): 818-820. 15 February 2001

Initial sequencing and analysis of the human genome.
Lander, E.S. and Linton, L.M. and Birren, B. and Nusbaum, C. and Zody, M.C. and Baldwin, J. and Devon, K. and Dewar, K. and Doyle, M. and FitzHugh, W. and Funke, R. and Gage, D. and Harris, K. and Heaford, A. and Howland, J. and Kann, L. and Lehoczky, J. and LeVine, R. and McEwan, P. and McKernan, K. and Meldrim, J. and Mesirov, J.P. and Miranda, C. and Morris, W. and Naylor, J. and Raymond, C. and Rosetti, M. and Santos, R. and Sheridan, A. and Sougnez, C. and Stange-Thomann, N. and Stojanovic, N. and Subramanian, A. and Wyman, D. and Rogers, J. and Sulston, J. and Ainscough, R. and Beck, S. and Bentley, D. and Burton, J. and Clee, C. and Carter, N. and Coulson, A. and Deadman, R. and Deloukas, P. and Dunham, A. and Dunham, I. and Durbin, R. and French, L. and Grafham, D. and Gregory, S. and Hubbard, T. and Humphray, S. and Hunt, A. and Jones, M. and Lloyd, C. and McMurray, A. and Matthews, L. and Mercer, S. and Milne, S. and Mullikin, J.C. and Mungall, A. and Plumb, R. and Ross, M. and Shownkeen, R. and Sims, S. and Waterston, R.H. and Wilson, R.K. and Hillier, L.W. and McPherson, J.D. and Marra, M.A. and Mardis, E.R. and Fulton, L.A. and Chinwalla, A.T. and Pepin, K.H. and Gish, W.R. and Chissoe, S.L. and Wendl, M.C. and Delehaunty, K.D. and Miner, T.L. and Delehaunty, A. and Kramer, J.B. and Cook, L.L. and Fulton, R.S. and Johnson, D.L. and Minx, P.J. and Clifton, S.W. and Hawkins, T. and Branscomb, E. and Predki, P. and Richardson, P. and Wenning, S. and Slezak, T. and Doggett, N. and Cheng, J.F. and Olsen, A. and Lucas, S. and Elkin, C. and Uberbacher, E. and Frazier, M. and Gibbs, R.A. and Muzny, D.M. and Scherer, S.E. and Bouck, J.B. and Sodergren, E.J. and Worley, K.C. and Rives, C.M. and Gorrell, J.H. and Metzker, M.L. and Naylor, S.L. and Kucherlapati, R.S. and Nelson, D.L. and Weinstock, G.M. and Sakaki, Y. and Fujiyama, A. and Hattori, M. and Yada, T. and Toyoda, A. and Itoh, T. and Kawagoe, C. and Watanabe, H. and Totoki, Y. and Taylor, T. and Weissenbach, J. and Heilig, R. and Saurin, W. and Artiguenave, F. and Brottier, P. and Bruls, T. and Pelletier, E. and Robert, C. and Wincker, P. and Rosenthal, A. and Platzer, M. and Nyakatura, G. and Taudien, S. and Rump, A. and Yang, H.M. and Yu, J. and Wang, J. and Huang, G.Y. and Gu, J. and Hood, L. and Rowen, L. and Madan, A. and Qin, S.Z. and Davis, R.W. and Federspiel, N.A. and Abola, A.P. and Proctor, M.J. and Myers, R.M. and Schmutz, J. and Dickson, M. and Grimwood, J. and Cox, D.R. and Olson, M.V.
Nature 409 (6822): 860-921. 15 February 2001

Genome speak.
Bork, P. and Copley, R.
Nature 409 : 815. 1 January 2001

2000

Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III.
Gonczy, P. and Echeverri, G. and Oegema, K. and Coulson, A. and Jones, S.J. and Copley, R.R. and Duperon, J. and Oegema, J. and Brehm, M. and Cassin, E. and Hannak, E. and Kirkham, M. and Pichler, S. and Flohrs, K. and Goessen, A. and Leidel, S. and Alleaume, A.M. and Martin, C. and Ozlu, N. and Bork, P. and Hyman, A.A.
Nature 408 (6810): 331-336. 16 November 2000

ClC-5 Cl- -channel disruption impairs endocytosis in a mouse model for Dent's disease.
Piwon, N. and Guenther, W. and Schwake, M. and Boesl, M.R. and Jentsch, T.J.
Nature 408 (6810): 369-373. 16 November 2000

The mammalian sodium channel BNC1 is required for normal touch sensation.
Price, M.P. and Lewin, G.R. and McIlwrath, S.L. and Cheng, C. and Xie, J.H. and Heppenstall, P.A. and Stucky, C.L. and Mannsfeldt, A.G. and Brennan, T.J. and Drummond, H.A. and Qiao, J. and Benson, C.J. and Tarr, D.E. and Hrstka, R.F. and Yang, B.L. and Williamson, R.A. and Welsh, M.J.
Nature 407 (6807): 1007-1011. 26 October 2000

Kainate receptors and synaptic plasticity.
Nicoll, R.A. and Mellor, J. and Frerking, M. and Schmitz, D.
Nature 406 (6799): 957. 31 August 2000

A chemokine-driven positive feedback loop organizes lymphoid follicles.
Ansel, K.M. and Ngo, V.N. and Hyman, P.L. and Luther, S.A. and Foerster, R. and Sedgwick, J.D. and Browning, J.L. and Lipp, M. and Cyster, J.G.
Nature 406 (6793): 309-314. 20 July 2000

A function for dysfunction - Ion channels and disease.
Jentsch, T.J.
Nature 406 (6793): 236-237. 20 July 2000

Distinguished scientists back Germany's DFG . .
Jahn, R. and Boeck, A. and Breiner, K.M. and Breunig, K.D. and Bujard, H. and Campos-Ortega, J. and Ganten, D. and Grummt, I. and Gruss, P. and Goridis, C. and Huber, R. and Hoch, M. and Jaeckle, H. and Kahmann, R. and Koch-Brandt, C. and Leptin, M. and Michel, H. and Noegel, A. and Neher, E. and Nuesslein-Volhard, C. and Pfanner, N. and Sandhoff, K. and Schoen, A. and Schwille, P. and Simons, K. and Zrenner, E.
Nature 404 : 922-922. 27 April 2000

A constitutively open potassium channel formed by KCNQ1 and KCNE3.
Schroeder, B.C. and Waldegger, S. and Fehr, S. and Bleich, M. and Warth, R. and Greger, R. and Jentsch, T.J.
Nature 403 (6766): 196-199. 13 January 2000

1999

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions.
Sallusto, F. and Lenig, D. and Foerster, R. and Lipp, M. and Lanzavecchia, A.
Nature 401 (6754): 708-712. 14 October 1999

Cytochrome P450 2C is an EDHF synthase in coronary arteries.
Fisslthaler, B. and Popp, R. and Kiss, L. and Potente, M. and Harder, D.R. and Fleming, I. and Busse, R.
Nature 401 (6752): 493-497. 30 September 1999

Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP.
Yeung, K. and Seitz, T. and Li, S.F. and Janosch, P. and McFerran, B. and Kaiser, C. and Fee, F. and Katsanakis, K.D. and Rose, D.W. and Mischak, H. and Sedivy, J.M. and Kolch, W.
Nature 401 (6749): 173-177. 9 September 1999

The mahogany protein is a receptor involved in suppression of obesity.
Nagle, D.L. and McGrail, S.H. and Vitale, J. and Wolf, E.A. and Dussault, B.J. and DiRocco, L. and Holmgren, L. and Montagno, J. and Bork, P. and Huszar, D. and Fairchild-Huntress, V. and Ge, P. and Keilty, J. and Ebeling, C. and Baldini, L. and Gilchrist, J. and Burn, P. and Carlson, G.A. and Moore, K.J.
Nature 398 : 148-152. 11 March 1999

ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28.
Hutloff, A. and Dittrich, A.M. and Beier, K.C. and Eljaschewitsch, B. and Kraft, R. and Anagnostopoulos, I. and Kroczek, R.A.
Nature 397 (6716): 263-266. 21 January 1999

1998

Moderate loss of function of cyclic-AMP-modulated KCNQ2/KCNQ3 K+ channels causes epilepsy.
Schroeder, B.C. and Kubisch, C. and Stein, V. and Jentsch, T.J.
Nature 396 (6712): 687-690. 17 December 1998

Signal transduction. Docking IkappaB kinases.
Scheidereit, C.
Nature 395 : 225-226. 17 September 1998

Csk controls antigen receptor-mediated development and selection of T-lineage cells.
Schmedt, C. and Saijo, K. and Niidome, T. and Kühn, R. and Aizawa, S. and Tarakhovsky, A.
Nature 394 (6696): 901-904. 27 August 1998

Microdomains of GPI-anchored proteins in living cells revealed by crosslinking.
Friedrichson, T. and Kurzchalia, T.V.
Nature 394 (6695): 802-805. 20 August 1998

Electrical coupling underlies high-frequency oscillations in the hippocampus in vitro.
Draguhn, A. and Traub, R.D. and Schmitz, D. and Jefferys, J.G.R.
Nature 394 (6689): 189-192. 9 July 1998

CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells.
Henn, V. and Slupsky, J.R. and Graefe, M. and Anagnostopoulos, I. and Foerster, R. and Mueller-Berghaus, G. and Kroczek, R.A.
Nature 391 (667): 591-594. 1 January 1998

1997

Severe neuropathies in mice with targeted mutations in the ErbB3 receptor.
Riethmacher, D. and Sonnenberg-Riethmacher, E. and Brinkmann, V. and Yamaai, T. and Lewin, G.R. and Birchmeier, C.
Nature 389 (6652): 725-730. 16 October 1997

More hippocampal neurons in adult mice living in an enriched environment.
Kempermann, G. and Kuhn, H.G. and Gage, F.H.
Nature 386 (6624): 493-495. 3 April 1997

Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation.
Plemper, R.K. and Bohmler, S. and Bordallo, J. and Sommer, T. and Wolf, D.H.
Nature 388 : 891-895. 1 January 1997

1996

Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis.
Weidner, K.M. and Dicesare, S. and Sachs, M. and Brinkmann, V. and Behrens, J. and Birchmeier, W.
Nature 384 (6605): 173-176. 14 November 1996

Two physically distinct pores in the dimeric ClC-0 chloride channel.
Ludewig, U. and Pusch, M. and Jentsch, T.J.
Nature 383 (6598): 340-343. 26 September 1996

The C5a chemoattractant receptor mediates mucosal defence to infection.
Höpken, U.E. and Lu, B. and Gerard, N.P. and Gerard, C.
Nature 383 (6595): 86-89. 5 September 1996

Functional interaction of beta-catenin with the transcription factor LEF-1.
Behrens, J. and von Kries, J.P. and Kuehl, M. and Bruhn, L. and Wedlich, D. and Grosschedl, R. and Birchmeier, W.
Nature 382 (6592): 638-642. 15 August 1996

A common molecular basis for three inherited kidney stone diseases.
Lloyd, S.E. and Pearce, S.H. and Fisher, S.E. and Steinmeyer, K. and Schwappach, B. and Scheinman, S.J. and Harding, B. and Bolino, A. and Devoto, M. and Goodyer, P. and Rigden, S.P. and Wrong, O. and Jentsch, T.J. and Craig, I.W. and Thakker, R.V.
Nature 379 (6564): 445-449. 1 February 1996

Requirement of mammalian DNA polymerase-beta in base-excision repair.
Sobol, R.W. and Horton, J.K. and Kühn, R. and Gu, H. and Singhal, R.K. and Prasad, R. and Rajewsky, K. and Wilson, S.H.
Nature 379 (6561): 183-186. 11 January 1996

Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein.
Brocke, S. and Gijbels, K. and Allegretta, M. and Ferber, I. and Piercy, C. and Blankenstein, T. and Martin, R. and Utz, U. and Karin, N. and Mitchell, D. and Veromaa, T. and Waisman, A. and Gaur, A. and Conlon, P. and Ling, N. and Fairchild, P.J. and Wraith, D.C. and Ogarra, A. and Fathman, C.G. and Steinman, L.
Nature 379 (6563): 343-346. 1 January 1996

1995

Multiple essential functions of neuregulin in development.
Meyer, D. and Birchmeier, C.
Nature 378 (6555): 386-390. 23 November 1995

Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud.
Bladt, F. and Riethmacher, D. and Isenmann, S. and Aguzzi, A. and Birchmeier, C.
Nature 376 (6543): 768-771. 31 August 1995

Scatter factor/hepatocyte growth factor is essential for liver development.
Schmidt, C. and Bladt, F. and Goedecke, S. and Brinkmann, V. and Zschiesche, W. and Sharpe, M. and Gherardi, E. and Birchmeier, C.
Nature 373 (6515): 699-702. 23 February 1995

Gating of the voltage-dependent chloride channel CIC-0 by the permeant anion.
Pusch, M. and Ludewig, U. and Rehfeldt, A. and Jentsch, T.J.
Nature 373 (6514): 527-531. 9 February 1995

Challenging times for bioinformatics.
Casari, G. and Andrade, M.A. and Bork, P. and Daruvar, A. and Ouzounis, C. and Schneider, R. and Tamames, J. and Valencia, A. and Sander, C.
Nature 376 : 647-648. 1 January 1995

Distinct functions for the two importin subunits in nuclear protein import.
Goerlich, D. and Vogel, F. and Mills, A.D. and Hartmann, E. and Laskey, R.A.
Nature 377 : 246-248. 1 January 1995

1994

Implications for dorsoventral axis determination from the zebrafish mutation janus.
Abdelilah, S. and Solnica-Krezel, L. and Stainier, D.Y. and Driever, W.
Nature 370 (6489): 468-471. 11 August 1994

NMDA receptors and activity-dependent tuning of the receptive fields of spinal cord neurons.
Lewin, G.R. and Mckintosh, E. and McMahon, S.B.
Nature 369 (6480): 482-485. 9 June 1994

Trinity of cation channels.
Jentsch, T.J.
Nature 367 (6462): 412-413. 3 February 1994

Evolutionary conservation of components of the protein translocation complex.
Hartmann, E. and Sommer, T. and Prehn, S. and Goerlich, D. and Jentsch, S. and Rapoport, T.A.
Nature 367 : 654-657. 1 January 1994

1993

Universal nucleic acid-binding domain revealed by crystal structure of the B. subtilis major cold-shock protein.
Schindelin, H. and Marahiel, M.A. and Heinemann, U.
Nature 364 (6433): 164-168. 8 July 1993

Inhibition of neurotransmitter release by C2-domain peptides implicates synaptotagmin in exocytosis.
Bommert, K. and Charlton, M.P. and DeBello, W.M. and Chin, G.J. and Betz, H. and Augustine, G.J.
Nature 363 (6425): 163-165. 13 May 1993

A yeast artificial chromosome covering the tyrosinase gene confers copy number-dependent expression in transgenic mice.
Schedl, A. and Montoliu, L. and Kelsey, G. and Schutz, G.
Nature 362 (6417): 258-261. 18 March 1993

Qa-2 molecules are peptide receptors of higher stringency than ordinary class I molecules.
Roetzschke, O. and Falk, K. and Stevanovic, S. and Grahovac, B. and Soloski, M.J. and Jung, G. and Rammensee, H.G.
Nature 361 (6413): 642-644. 18 February 1993

Benzodiazepine-induced motor impairment linked to point mutation in cerebellar GABAA receptor.
Korpi, E.R. and Kleingoor, C. and Kettenmann, H. and Seeburg, P.H.
Nature 361 : 356-359. 1 January 1993

A protein translocation defect linked to ubiquitin conjugation at the endoplasmic reticulum.
Sommer, T. and Jentsch, S.
Nature 365 : 176-179. 1 January 1993

1992

Regions involved in the opening of CIC-2 chloride channel by voltage and cell volume.
Gruender, S. and Thiemann, A. and Pusch, M. and Jentsch, T.J.
Nature 360 (6406): 759-762. 24 December 1992

Molecular identification of the gene responsible for congenital nephrogenic diabetes insipidus.
Rosenthal, W. and Seibold, A. and Antaramian, A. and Lonergan, M. and Arthus, M.F. and Hendy, G.N. and Birnbaumer, M. and Bichet, D.G.
Nature 359 (6392): 233-235. 17 September 1992

Molecular cloning of the receptor for human antidiuretic hormone.
Birnbaumer, M. and Seibold, A. and Gilbert, S. and Ishido, M. and Barberis, C. and Antaramian, A. and Brabet, P. and Rosenthal, W.
Nature 357 (6376): 333-335. 28 May 1992

A chloride channel widely expressed in epithelial and non-epithelial cells.
Thiemann, A. and Gruender, S. and Pusch, M. and Jentsch, T.J.
Nature 356 (6364): 57-60. 5 March 1992

What's in a genome?
Bork, P. and Ouzounis, C. and Sander, C. and Scharf, M. and Schneider, R. and Sonnhammer, E.
Nature 358 : 287. 1 January 1992

A protein of the endoplasmic reticulum involved early in polypeptide translocation.
Goerlich, D. and Hartmann, E. and Prehn, S. and Rapoport, T.A.
Nature 357 : 47-52. 1 January 1992

Signal sequence identified.
Hartmann, E. and Rapoport, T.A. and Prehn, S.
Nature 358 : 198. 1 January 1992

Candidate proto-oncogene bcl-3 encodes a subunit-specific inhibitor of transcription factor NF-kappaB.
Wulczyn, F.G. and Naumann, M. and Scheidereit, C.
Nature 358 (6387): 597-599. 1 January 1992

1991

Inactivation of muscle chloride channel by transposon insertion in myotonic mice.
Steinmeyer, K. and Klocke, R. and Ortland, C. and Gronemeier, M. and Jockusch, H. and Gruender, S. and Jentsch, T.J.
Nature 354 (6351): 304-308. 28 November 1991

Primary structure and functional expression of a developmentally regulated skeletal muscle chloride channel.
Steinmeyer, K. and Ortland, C. and Jentsch, T.J.
Nature 354 (6351): 301-304. 28 November 1991

Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats.
Hilbert, P. and Lindpaintner, K. and Beckmann, J.S. and Serikawa, T. and Soubrier, F. and Dubay, C.J. and Cartwright, P. and De Gouyon, B. and Julier, C. and Takahashi, S. and Vincent, M. and Ganten, D. and Georges, M. and Lathrop, G.M.
Nature 353 (6344): 521-529. 10 October 1991

Assignment of G-protein subtypes to specific receptors inducing inhibition of calcium currents.
Kleuss, C. and Hescheler, J. and Ewel, C. and Rosenthal, W. and Schultz, G. and Wittig, B.
Nature 353 (6339): 43-48. 5 September 1991

A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene.
Kitamura, D. and Roes, J. and Kühn, R. and Rajewsky, K.
Nature 350 (6317): 423-426. 4 April 1991

Protein translocation. A bacterium catches up.
Rapoport, T.A.
Nature 349 : 107-108. 1 January 1991

1990

Primary structure of Torpedo marmorata chloride channel isolated by expression cloning in Xenopus oocytes.
Jentsch, T.J. and Steinmeyer, K. and Schwarz, G.
Nature 348 (6301): 510-514. 6 December 1990

1987

The GTP-binding protein, Go, regulates neuronal calcium channels.
Hescheler, J. and Rosenthal, W. and Trautwein, W. and Schultz, G.
Nature 325 (6103): 445-447. 29 January 1987