Browse by Research Team

2024

In preprints: keeping endothelial cell specification and vascular development in check.
Petzold, T. and Gerhardt, H.
Development 151 (18): dev204338. September 2024

Intramyocardial sprouting tip cells specify coronary arterialization.
Cano, E., Schwarzkopf, J., Kanda, M., Lindberg, E.L., Hollfinger, I., Pogontke, C., Braeuning, C., Fischer, C., Hübner, N. and Gerhardt, H.
Circulation Research 135 (6): 671-684. 30 August 2024

Converting PROMIS®-29 v2.0 profile data to SF-36 physical and mental component summary scores in patients with cardiovascular disorders.
Liegl, G., Fischer, F.H., Martin, C.N., Rönnefarth, M., Blumrich, A., Ahmadi, M., Boldt, L.H., Eckardt, K.U., Endres, M., Edelmann, F., Gerhardt, H., Grittner, U., Haghikia, A., Hübner, N., Landmesser, U., Leistner, D., Mai, K., Kollmus-Heege, J., Müller, D.N., Nolte, C.H., Piper, S.K., Schmidt-Ott, K.M., Pischon, T., Rattan, S., Rohrpasser-Napierkowski, Ira, Schönrath, K., Schulz-Menger, J., Schweizerhof, O., Spranger, J., Weber, J.E., Witzenrath, M., Schmidt, S. and Rose, M.
Health and Quality of Life Outcomes 22 (1): 64. 15 August 2024

External mechanical stability regulates hematoma vascularization in bone healing rather than endothelial YAP/TAZ mechanotransduction.
Mehl, J., Farahani, S.K., Brauer, E., Klaus-Bergmann, A., Thiele, T., Ellinghaus, A., Bartels-Klein, E., Koch, K., Schmidt-Bleek, K., Petersen, A., Gerhardt, H., Vogel, V. and Duda, G.N.
Advanced Science 11 (13): e2307050. 3 April 2024

Pial collaterals develop through mosaic colonization of capillaries by arterial and microvascular endothelial cells.
Perovic, T., Hollfinger, I., Mayer, S., Lips, J., Dopatka, M., Harms, C. and Gerhardt, H.
bioRxiv : 2023.10.09.561542v3. 7 February 2024

2023

External mechanical loading overrules cell-cell mechanical communication in sprouting angiogenesis during early bone regeneration.
Dazzi, C., Mehl, J., Benamar, M., Gerhardt, H., Knaus, P., Duda, G.N. and Checa, S.
PLoS Computational Biology 19 (11): e1011647. 13 November 2023

Single-cell profiling and zebrafish avatars reveal LGALS1 as immunomodulating target in glioblastoma.
Finotto, L., Cole, B., Giese, W., Baumann, E., Claeys, A., Vanmechelen, M., Decraene, B., Derweduwe, M., Dubroja Lakic, N., Shankar, G., Nagathihalli Kantharaju, M., Albrecht, J.P., Geudens, I., Stanchi, F., Ligon, K.L., Boeckx, B., Lambrechts, D., Harrington, K., Van Den Bosch, L., De Vleeschouwer, S., De Smet, F. and Gerhardt, H.
EMBO Molecular Medicine 15 (11): e18144. 8 November 2023

Protocol of the Berlin Long-term Observation of Vascular Events (BeLOVE): a prospective cohort study with deep phenotyping and long-term follow up of cardiovascular high-risk patients.
Weber, J.E., Ahmadi, M., Boldt, L.H., Eckardt, K.U., Edelmann, F., Gerhardt, H., Grittner, U., Haubold, K., Hübner, N., Kollmus-Heege, J., Landmesser, U., Leistner, D.M., Mai, K., Müller, D.N., Nolte, C.H., Pieske, B., Piper, S.K., Rattan, S., Rauch, G., Schmidt, S., Schmidt-Ott, K.M., Schönrath, K., Schulz-Menger, J., Schweizerhof, O., Siegerink, B., Spranger, J., Ramachandran, V.S., Witzenrath, M., Endres, M. and Pischon, T.
BMJ Open 13 (10): e076415. 31 October 2023

A 96-wells fluidic system for high-throughput screenings under laminar high wall shear stress conditions.
Fonseca, C.G., Silvério, V., Barata, D., Giese, W., Gerhardt, H., Cardoso, S. and Franco, C.A.
Microsystems & Nanoengineering 9 : 114. 15 September 2023

Influence of phosphorylation on intermediate filaments.
Kraxner, J. and Köster, S.
Biological Chemistry 404 (8-9): 821-827. 20 April 2023

2022

Tyrosine-protein kinase Yes controls endothelial junctional plasticity and barrier integrity by regulating VE-cadherin phosphorylation and endocytosis.
Jin, Y., Ding, Y., Richards, M., Kaakinen, M., Giese, W., Baumann, E., Szymborska, A., Rosa, A., Nordling, S., Schimmel, L., Akmeriç, E.B., Pena, A., Nwadozi, E., Jamalpour, M., Holstein, K., Sáinz-Jaspeado, M., Bernabeu, M.O., Welsh, M., Gordon, E., Franco, C.A., Vestweber, D., Eklund, L., Gerhardt, H. and Claesson-Welsh, L.
Nature Cardiovascular Research 1 (12): 1156–1173. December 2022

Vascular and liver homeostasis in juvenile mice require endothelial cyclic AMP-dependent protein kinase A.
Nedvetsky, P.I., Cornelissen, I., Mathivet, T., Bouleti, C., Ou, P., Baatsen, P., Zhao, X., Schuit, F., Stanchi, F., Mostov, K.E. and Gerhardt, H.
International Journal of Molecular Sciences 23 (19): 11419. 27 September 2022

Blood flow meets mitophagy.
Akmeriç, E.B. and Gerhardt, H.
Journal of Cell Biology 221 (7): e202206033. 4 July 2022

A YAP/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth.
Ong, Y.T., Andrade, J., Armbruster, M., Shi, C., Castro, M., Costa, A.S.H., Sugino, T., Eelen, G., Zimmermann, B., Wilhelm, K., Lim, J., Watanabe, S., Guenther, S., Schneider, A., Zanconato, F., Kaulich, M., Pan, D., Braun, T., Gerhardt, H., Efeyan, A., Carmeliet, P., Piccolo, S., Grosso, A.R. and Potente, M.
Nature Metabolism 4 (6): 672-682. June 2022

Brief research report: Quantitative analysis of potential coronary microvascular disease in suspected long-COVID syndrome.
Doeblin, P., Steinbeis, F., Scannell, C.M., Goetze, C., Al-Tabatabaee, S., Erley, J., Faragli, A., Pröpper, F., Witzenrath, M., Zoller, T., Stehning, C., Gerhardt, H., Sánchez-González, J., Alskaf, E., Kühne, T., Pieske, B., Tschöpe, C., Chiribiri, A. and Kelle, S.
Frontiers in Cardiovascular Medicine 9 : 877416. 31 May 2022

Svep1 stabilises developmental vascular anastomosis in reduced flow conditions.
Coxam, B., Collins, R.T., Hußmann, M., Huisman, Y., Meier, K., Jung, S., Bartels-Klein, E., Szymborska, A., Finotto, L., Helker, C.S.M., Stainier, D.Y.R., Schulte-Merker, S. and Gerhardt, H.
Development 149 (6): dev199858. 24 March 2022

Formation and maintenance of the natural bypass vessels of the brain.
Perovic, T., Harms, C. and Gerhardt, H.
Frontiers in Cardiovascular Medicine 9 : 778773. 22 March 2022

The genetic basis of Moyamoya disease.
Mertens, R., Graupera, M., Gerhardt, H., Bersano, A., Tournier-Lasserve, E., Mensah, M.A., Mundlos, S. and Vajkoczy, P.
Translational Stroke Research 13 (1): 25-45. February 2022

WASp controls oriented migration of endothelial cells to achieve functional vascular patterning.
Rosa, A., Giese, W., Meier, K., Alt, S., Klaus-Bergmann, A., Edgar, L.T., Bartels, E., Collins, R., Szymborska, A., Coxam, B., Bernabeu, M.O. and Gerhardt, H.
Development 149 (3): dev200195. February 2022

2021

A backward-mode optical-resolution photoacoustic microscope for 3D imaging using a planar Fabry-Pérot sensor.
Baumann, E., Pohle, U., Zhang, E., Allen, T., Villringer, C., Pulwer, S., Gerhardt, H. and Laufer, J.
Photoacoustics 24 : 100293. December 2021

Pericyte insulin receptors modulate retinal vascular remodeling and endothelial angiopoietin signaling.
Warmke, N., Platt, F., Bruns, A.F., Ozber, C.H., Haywood, N.J., Abudushalamu, Y., Slater, C., Palin, V., Sukumar, P., Wheatcroft, S.B., Yuldasheva, N.Y., Kearney, M.T., Griffin, K.J. and Cubbon, R.M.
Endocrinology 162 (11): bqab182. 1 November 2021

Three-dimensional superresolution fluorescence microscopy maps the variable molecular architecture of the nuclear pore complex.
Sabinina, V.J., Hossain, M.J., Hériché, J.K., Hoess, P., Nijmeijer, B., Mosalaganti, S., Kueblbeck, M., Callegari, A., Szymborska, A., Beck, M., Ries, J. and Ellenberg, J.
Molecular Biology of the Cell 32 (17): 1523-1533. 15 August 2021

Emerging single cell endothelial heterogeneity supports sprouting tumour angiogenesis and growth.
Matsumoto, K., Rambow, F., Stanchi, F., Mathivet, T., Qian, J., Giese, W., He, L., Lambrechts, D., Zhou, B., Betsholtz, C., Marine, J.C. and Gerhardt, H.
bioRxiv : 2021.06.09.447719. 11 June 2021

Association between erythrocyte dynamics and vessel remodelling in developmental vascular networks.
Zhou, Q., Perovic, T., Fechner, I., Edgar, L.T., Hoskins, P.R., Gerhardt, H., Krüger, T. and Bernabeu, M.O.
Journal of the Royal Society Interface 18 (179): 20210113. June 2021

Remodeling of an in vitro microvessel exposed to cyclic mechanical stretch.
Zeinali, S., Thompson, E.K., Gerhardt, H., Geiser, T. and Guenat, O.T.
APL Bioengineering 5 (2): 026102. June 2021

Astrocyte-derived Wnt growth factors are required for endothelial blood-brain barrier maintenance.
Guérit, S., Fidan, E., Macas, J., Czupalla, C.J., Figueiredo, R., Vijikumar, A., Yalcin, B.H., Thom, S., Winter, P., Gerhardt, H., Devraj, K. and Liebner, S.
Progress in Neurobiology 199 : 101937. April 2021

Endothelial cell orientation and polarity are controlled by shear stress and VEGF through distinct signaling pathways.
Vion, A.C., Perovic, T., Petit, C., Hollfinger, I., Bartels-Klein, E., Frampton, E., Gordon, E., Claesson-Welsh, L. and Gerhardt, H.
Frontiers in Physiology 11 : 623769. 2 March 2021

Vasohibin-1 selectively regulates secondary sprouting and lymphangiogenesis in the zebrafish trunk.
Bastos de Oliveira, M., Meier, K., Jung, S., Bartels-Klein, E., Coxam, B., Geudens, I., Szymborska, A., Skoczylas, R., Fechner, I., Koltowska, K. and Gerhardt, H.
Development 148 (4): dev194993. 19 February 2021

On the preservation of vessel bifurcations during flow-mediated angiogenic remodelling.
Edgar, L.T., Franco, C.A., Gerhardt, H. and Bernabeu, M.O.
PLoS Computational Biology 17 (2): e1007715. 4 February 2021

2020

Long-lived tumor-associated macrophages in glioma.
Georgieva, P.B., Mathivet, T., Alt, S., Giese, W., Riva, M., Balcer, M. and Gerhardt, H.
Neuro-Oncology Advances 2 (1): vdaa127. 9 November 2020

Intron with transgenic marker (InTraM) facilitates high-throughput screening of endogenous gene reporter lines.
Collins, R.T., Coxam, B., Fechner, I., Unterweger, I., Szymborska, A., Meier, K. and Gerhardt, H.
Genesis 58 (10-11): e23391. November 2020

Lymphoma angiogenesis is orchestrated by noncanonical signaling pathways.
Gloger, M., Menzel, L., Grau, M., Vion, A.C., Anagnostopoulos, I., Zapukhlyak, M., Gerlach, K., Kammertöns, T., Hehlgans, T., Zschummel, M., Lenz, G., Gerhardt, H., Höpken, U.E. and Rehm, A.
Cancer Research 80 (6): 1316-1329. March 2020

DLC1 is a direct target of activated YAP/TAZ that drives collective migration and sprouting angiogenesis.
van der Stoel, M., Schimmel, L., Nawaz, K., van Stalborch, A.M., de Haan, A., Klaus-Bergmann, A., Valent, E.T., Koenis, D.S., van Nieuw Amerongen, G.P., de Vries, C.J., de Waard, V., Gloerich, M., van Buul, J.D. and Huveneers, S.
Journal of Cell Science 133 (3): jcs239947. 12 February 2020

Opposite macrophage polarization in different subsets of ovarian cancer: observation from a pilot study.
Vankerckhoven, A., Wouters, R., Mathivet, T., Ceusters, J., Baert, T., Van Hoylandt, A., Gerhardt, H., Vergote, I. and Coosemans, A.
Cells 9 (2): 305. 27 January 2020

2019

Endothelial PKA activity regulates angiogenesis by limiting autophagy through phosphorylation of ATG16L1.
Zhao, X., Nedvetsky, P., Stanchi, F., Vion, A.C., Popp, O., Zühlke, K., Dittmar, G., Klussmann, E. and Gerhardt, H.
eLife 8 : e46380. 3 October 2019

Artery-vein specification in the zebrafish trunk is pre-patterned by heterogeneous Notch activity and balanced by flow-mediated fine tuning.
Geudens, I., Coxam, B., Alt, S., Gebala, V., Vion, A.C., Meier, K., Rosa, A. and Gerhardt, H.
Development 146 (16): dev.181024. 27 August 2019

Mesothelial-mesenchymal transitions in embryogenesis.
Carmona, R., Ariza, L., Cano, E., Jiménez-Navarro, M. and Muñoz-Chápuli, R.
Seminars in Cell & Developmental Biology 92 : 37-44. August 2019

Disease overarching mechanisms that explain and predict outcome of patients with high cardiovascular risk: rationale and design of the Berlin Long-term Observation of vascular events (BeLOVE) study.
Siegerink, B., Weber, J., Ahmadi, M., Eckardt, K.U., Edelmann, F., Endres, M., Gerhardt, H., Haubold, K., Hübner, N., Landmesser, U., Leistner, D., Mai, K., Müller, D.N., Pieske, B., Rauch, G., Schmidt, S., Schmidt-Ott, K., Schulz-Menger, J., Spranger, J. and Pischon, T.
medRxiv : 19001024. 15 July 2019

ATTRACT: arterial flow as attractor for endothelial cell migration.
Georgieva, P.B., Marchuk, D.A. and Gerhardt, H.
Circulation Research 125 (3): 262-264. July 2019

GPIHBP1 expression in gliomas promotes utilization of lipoprotein-derived nutrients.
Hu, X., Matsumoto, K., Jung, R.S., Weston, T.A., Heizer, P.J., He, C., Sandoval, N.P., Allan, C.M., Tu, Y., Vinters, H.V., Liau, L.M., Ellison, R.M., Morales, J.E., Baufeld, L.J., Bayley, N.A., He, L., Betsholtz, C., Beigneux, A.P., Nathanson, D.A., Gerhardt, H., Young, S.G., Fong, L.G. and Jiang, H.
eLife 8 : e47178. 6 June 2019

Development of a backward-mode photoacoustic microscope using a Fabry-Pérot sensor.
Pohle, U., Baumann, E., Pulwer, S., Villringer, C., Zhang, E.Z., Gerhardt, H. and Laufer, J.
In: SPIE BiOS 2019, 2-7 Feb 2019, San Francisco, CA, USA. 6 March 2019

Tissue curvature and apicobasal mechanical tension imbalance instruct cancer morphogenesis.
Messal, H.A., Alt, S., Ferreira, R.M.M., Gribben, C., Wang, V.M.Y., Cotoi, C.G., Salbreux, G. and Behrens, A.
Nature 566 (7742): 126-130. 7 February 2019

Endothelial calcineurin signaling restrains metastatic outgrowth by regulating Bmp2.
Hendrikx, S., Coso, S., Prat-Luri, B., Wetterwald, L., Sabine, A., Franco, C.A., Nassiri, S., Zangger, N., Gerhardt, H., Delorenzi, M. and Petrova, T.V.
Cell Reports 26 (5): 1227-1241. 29 January 2019

Imaging glioma progression by intravital microscopy.
Stanchi, F., Matsumoto, K. and Gerhardt, H.
Methods in Molecular Biology 1862 : 227-243. 2019

2018

Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility.
Angulo-Urarte, A., Casado, P., Castillo, S.D., Kobialka, P., Kotini, M.P., Figueiredo, A.M., Castel, P., Rajeeve, V., Milà-Guasch, M., Millan, J., Wiesner, C., Serra, H., Muixi, L., Casanovas, O., Viñals, F., Affolter, M., Gerhardt, H., Huveneers, S., Belting, H.G., Cutillas, P.R. and Graupera, M.
Nature Communications 9 (1): 4826. 16 November 2018

NanoSIMS imaging reveals unexpected heterogeneity in nutrient uptake by brown adipocytes.
He, C., Hu, X., Weston, T.A., Jung, R.S., Heizer, P., Tu, Y., Ellison, R., Matsumoto, K., Gerhardt, H., Tontonoz, P., Fong, L.G., Young, S.G. and Jiang, H.
Biochemical and Biophysical Research Communications 504 (4): 899-902. 12 October 2018

Mutations in disordered regions can cause disease by creating dileucine motifs.
Meyer, K., Kirchner, M., Uyar, B., Cheng, J.Y., Russo, G., Hernandez-Miranda, L.R., Szymborska, A., Zauber, H., Rudolph, I.M., Willnow, T.E., Akalin, A., Haucke, V., Gerhardt, H., Birchmeier, C., Kühn, R., Krauss, M., Diecke, S., Pascual, J.M. and Selbach, M.
Cell 175 (1): 239-253. 20 September 2018

PAR-3 controls endothelial planar polarity and vascular inflammation under laminar flow.
Hikita, T., Mirzapourshafiyi, F., Barbacena, P., Riddell, M., Pasha, A., Li, M., Kawamura, T., Brandes, R.P., Hirose, T., Ohno, S., Gerhardt, H., Matsuda, M., Franco, C.A. and Nakayama, M.
EMBO Reports 19 (9): e45253. 1 September 2018

Hold me, but not too tight - endothelial cell-cell junctions in angiogenesis.
Szymborska, A. and Gerhardt, H.
Cold Spring Harbor Perspectives in Biology 10 (8): a029223. August 2018

Apical and basal matrix remodeling control epithelial morphogenesis.
Diaz-de-la-Loza, M.D.C., Ray, R.P., Ganguly, P.S., Alt, S., Davis, J.R., Hoppe, A., Tapon, N., Salbreux, G. and Thompson, B.J.
Developmental Cell 46 (1): 23-39. 2 July 2018

PolNet: a tool to quantify network-level cell polarity and blood flow in vascular remodeling.
Bernabeu, M.O., Jones, M.L., Nash, R.W., Pezzarossa, A., Coveney, P.V., Gerhardt, H. and Franco, C.A.
Biophysical Journal 114 (9): 2052-2058. 8 May 2018

Primary cilia sensitize endothelial cells to BMP and prevent excessive vascular regression.
Vion, A.C., Alt, S., Klaus-Bergmann, A., Szymborska, A., Zheng, T., Perovic, T., Hammoutene, A., Oliveira, M.B., Bartels-Klein, E., Hollfinger, I., Rautou, P.E., Bernabeu, M.O. and Gerhardt, H.
Journal of Cell Biology 217 (5): 1651-1665. 7 May 2018

YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development.
Neto, F., Klaus-Bergmann, A., Ong, Y.T., Alt, S., Vion, A.C., Szymborska, A., Carvalho, J.R., Hollfinger, I., Bartels-Klein, E., Franco, C.A., Potente, M. and Gerhardt, H.
eLife 7 : e31037. 5 February 2018

Imaging of endothelial cell dynamic behavior in zebrafish.
Coxam, B. and Gerhardt, H.
Methods in Molecular Biology 1846 : 181-195. 2018

2017

Dynamic stroma reorganization drives blood vessel dysmorphia during glioma growth.
Mathivet, T., Bouleti, C., Van Woensel, M., Stanchi, F., Verschuere, T., Phng, L.K., Dejaegher, J., Balcer, M., Matsumoto, K., Georgieva, P.B., Belmans, J., Sciot, R., Stockmann, C., Mazzone, M., De Vleeschouwer, S. and Gerhardt, H.
EMBO Molecular Medicine 9 (12): 1629-1645. 1 December 2017

Mouse cutaneous melanoma induced by mutant BRaf arises from expansion and dedifferentiation of mature pigmented melanocytes.
Köhler, C., Nittner, D., Rambow, F., Radaelli, E., Stanchi, F., Vandamme, N., Baggiolini, A., Sommer, L., Berx, G., van den Oord, J.J., Gerhardt, H., Blanpain, C. and Marine, J.C.
Cell Stem Cell 21 (5): 679-693.e6. 2 November 2017

A map of human circular RNAs in clinically relevant tissues.
Maass, P.G., Glažar, P., Memczak, S., Dittmar, G., Hollfinger, I., Schreyer, L., Sauer, A.V., Toka, O., Aiuti, A., Luft, F.C. and Rajewsky, N.
Journal of Molecular Medicine 95 (11): 1179-1189. November 2017

A reversible haploid mouse embryonic stem cell biobank resource for functional genomics.
Elling, U., Wimmer, R.A., Leibbrandt, A., Burkard, T., Michlits, G., Leopoldi, A., Micheler, T., Abdeen, D., Zhuk, S., Aspalter, I.M., Handl, C., Liebergesell, J., Hubmann, M., Husa, A.M., Kinzer, M., Schuller, N., Wetzel, E., van de Loo, N., Martinez, J.A.Z., Estoppey, D., Riedl, R., Yang, F., Fu, B., Dechat, T., Ivics, Z., Agu, C.A., Bell, O., Blaas, D., Gerhardt, H., Hoepfner, D., Stark, A. and Penninger, J.M.
Nature 550 (7674): 114-118. 5 October 2017

The endothelial transcription factor ERG mediates angiopoietin-1-dependent control of notch signalling and vascular stability.
Shah, A.V., Birdsey, G.M., Peghaire, C., Pitulescu, M.E., Dufton, N.P., Yang, Y., Weinberg, I., Osuna Almagro, L., Payne, L., Mason, J.C., Gerhardt, H., Adams, R.H. and Randi, A.M.
Nature Communications 8 : 16002. 11 July 2017

Morph or move? How distinct endothelial cell responses to blood flow shape vascular networks.
Franco, C.A. and Gerhardt, H.
Developmental Cell 41 (6): 574-576. 19 June 2017

Tumour ischaemia by interferon-γ resembles physiological blood vessel regression.
Kammertoens, T., Friese, C., Arina, A., Idel, C., Briesemeister, D., Rothe, M., Ivanov, A., Szymborska, A., Patone, G., Kunz, S., Sommermeyer, D., Engels, B., Leisegang, M., Textor, A., Fehling, H.J., Fruttiger, M., Lohoff, M., Herrmann, A., Yu, H., Weichselbaum, R., Uckert, W., Hübner, N., Gerhardt, H., Beule, D., Schreiber, H. and Blankenstein, T.
Nature 545 (7652): 98-102. 4 May 2017

Sensitization of glioblastoma tumor micro-environment to chemo- and immunotherapy by Galectin-1 intranasal knock-down strategy.
Van Woensel, M., Mathivet, T., Wauthoz, N., Rosière, R., Garg, A.D., Agostinis, P., Mathieu, V., Kiss, R., Lefranc, F., Boon, L., Belmans, J., Van Gool, S.W., Gerhardt, H., Amighi, K. and De Vleeschouwer, S.
Scientific Reports 7 (1): 1217. 27 April 2017

Pericytes or mesenchymal stem cells: is that the question?
Cano, E., Gebala, V. and Gerhardt, H.
Cell Stem Cell 20 (3): 296-297. 2 March 2017

Role of vitamin A/retinoic acid in regulation of embryonic and adult hematopoiesis.
Canete, A., Cano, E., Munoz-Chapuli, R. and Carmona, R.
Nutrients 9 (2): 159. 20 February 2017

2016

cAMP-dependent protein kinase A (PKA) regulates angiogenesis by modulating tip cell behavior in a Notch-independent manner.
Nedvetsky, P.I., Zhao, X., Mathivet, T., Aspalter, I.M., Stanchi, F., Metzger, R.J., Mostov, K.E. and Gerhardt, H.
Development 143 (19): 3582-3590. 4 October 2016

Blood flow boosts BMP signaling to keep vessels in shape.
Franco, C.A. and Gerhardt, H.
Journal of Cell Biology 214 (7): 793-795. 26 September 2016

Conditional deletion of WT1 in the septum transversum mesenchyme causes congenital diaphragmatic hernia in mice.
Carmona, R., Canete, A., Cano, E., Ariza, L., Rojas, A. and Munoz-Chapuli, R.
eLife 5 : e16009. 19 September 2016

Glycolytic regulation of cell rearrangement in angiogenesis.
Cruys, B., Wong, B.W., Kuchnio, A., Verdegem, D., Cantelmo, A. R., Conradi, L.C., Vandekeere, S., Bouché, A., Cornelissen, I., Vinckier, S., Merks, R.M.H., Dejana, E., Gerhardt, H., Dewerchin, M., Bentley, K. and Carmeliet, P.
Nature Communications 7 : 12240. 20 July 2016

Integrin signalling regulates YAP and TAZ to control skin homeostasis.
Elbediwy, A., Vincent-Mistiaen, Z.I., Spencer-Dene, B., Stone, R.K., Boeing, S., Wculek, S.K., Cordero, J., Tan, E.H., Ridgway, R., Brunton, V.G., Sahai, E., Gerhardt, H., Behrens, A., Malanchi, I., Sansom, O.J. and Thompson, B.J.
Development 143 (10): 1674-1687. 15 May 2016

Synchronization of endothelial Dll4-Notch dynamics switch blood vessels from branching to expansion.
Ubezio, B., Blanco, R.A., Geudens, I., Stanchi, F., Mathivet, T., Jones, M.L., Ragab, A., Bentley, K. and Gerhardt, H.
eLife 5 : e12167. 13 April 2016

Development of siRNA-loaded chitosan nanoparticles targeting Galectin-1 for the treatment of glioblastoma multiforme via intranasal administration.
Van Woensel, M., Wauthoz, N., Rosière, R., Mathieu, V., Kiss, R., Lefranc, F., Steelant, B., Dilissen, E., Van Gool, S.W., Mathivet, T., Gerhardt, H., Amighi, K. and De Vleeschouwer, S.
Journal of Controlled Release 227 : 71-81. 10 April 2016

Blood flow drives lumen formation by inverse membrane blebbing during angiogenesis in vivo.
Gebala, V., Collins, R., Geudens, I., Phng, L.K. and Gerhardt, H.
Nature Cell Biology 18 (4): 443-450. April 2016

Coelomic epithelium-derived cells in visceral morphogenesis.
Ariza, L., Carmona, R., Canete, A., Cano, E. and Munoz-Chapuli, R.
Developmental Dynamics 245 (3): 307-322. March 2016

Non-canonical Wnt signalling modulates the endothelial shear stress flow sensor in vascular remodelling.
Franco, C.A., Jones, M.L., Bernabeu, M.O., Vion, A.C., Barbacena, P., Fan, J., Mathivet, T., Fonseca, C.G., Ragab, A., Yamaguchi, T.P., Coveney, P.V., Lang, R.A. and Gerhardt, H.
eLife 5 : e07727. 4 February 2016

Knockout of the PKN family of Rho effector kinases reveals a non-redundant role for PKN2 in developmental mesoderm expansion.
Quétier, I., Marshall, J.J.T., Spencer-Dene, B., Lachmann, S., Casamassima, A., Franco, C., Escuin, S., Worrall, J.T., Baskaran, P., Rajeeve, V., Howell, M., Copp, A.J., Stamp, G., Rosewell, I., Cutillas, P., Gerhardt, H., Parker, P.J. and Cameron, A.J.M.
Cell Reports 14 (3): 440-448. 26 January 2016

Extracardiac septum transversum/proepicardial endothelial cells pattern embryonic coronary arterio-venous connections.
Cano, E., Carmona, R., Ruiz-Villalba, A., Rojas, A., Chau, Y.Y., Wagner, K.D., Wagner, N., Hastie, N.D., Munoz-Chapuli, R. and Perez-Pomares, J.M.
Proceedings of the National Academy of Sciences of the United States of America 113 (3): 656-661. 19 January 2016

FOXO1 couples metabolic activity and growth state in the vascular endothelium.
Wilhelm, K., Happel, K., Eelen, G., Schoors, S., Oellerich, M.F., Lim, R., Zimmermann, B., Aspalter, I.M., Franco, C.A., Boettger, T., Braun, T., Fruttiger, M., Rajewsky, K., Keller, C., Brüning, J.C., Gerhardt, H., Carmeliet, P. and Potente, M.
Nature 529 (7585): 216-220. 14 January 2016

2015

PTEN mediates Notch-dependent stalk cell arrest in angiogenesis.
Serra, H., Chivite, I., Angulo-Urarte, A., Soler, A., Sutherland, J.D., Arruabarrena-Aristorena, A., Ragab, A., Lim, R., Malumbres, M., Fruttiger, M., Potente, M., Serrano, M., Fabra, A., Vinals, F., Casanovas, O., Pandolfi, P.P., Bigas, A., Carracedo, A., Gerhardt, H. and Graupera, M.
Nature Communications 6 : 7935. 31 July 2015

Wiring the vascular network with neural cues: a CNS perspective.
Waächli, T., Wacker, A., Frei, K., Regli, L., Schwab, M.E., Hoerstrup, S.P., Gerhardt, H. and Engelhardt, B.
Neuron 87 (2): 271-296. 15 July 2015

Endothelial alpha-parvin controls integrity of developing vasculature and is required for maintenance of cell-cell junctions.
Fraccaroli, A., Pitter, B., Taha, A.A., Seebach, J., Huveneers, S., Kirsch, J., Casaroli-Marano, R.P., Zahler, S., Pohl, U., Gerhardt, H., Schnittler, H.J. and Montanez, E.
Circulation Research 117 (1): 29-40. 19 June 2015

Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch.
Aspalter, I.M., Gordon, E., Dubrac, A., Ragab, A., Narloch, J., Vizán, P., Geudens, I., Collins, R.T., Franco, C.A., Abrahams, C.L., Thurston, G., Fruttiger, M., Rosewell, I., Eichmann, A. and Gerhardt, H.
Nature Communications 6 : 7264. 17 June 2015

Dynamic endothelial cell rearrangements drive developmental vessel regression.
Franco, C.A., Jones, M.L., Bernabeu, M.O., Geudens, I., Mathivet, T., Rosa, A., Lopes, F.M., Lima, A.P., Ragab, A., Collins, R.T., Phng, L.K., Coveney, P.V. and Gerhardt, H.
PLoS Biology 13 (4): e1002125. 17 April 2015

Fatty acid carbon is essential for dNTP synthesis in endothelial cells.
Schoors, S., Bruning, U., Missiaen, R., Queiroz, K.C.S., Borgers, G., Elia, I., Zecchin, A., Cantelmo, A.R., Christen, S., Goveia, J., Heggermont, W., Goddé, L., Vinckier, S., Van Veldhoven, P.P., Eelen, G., Schoonjans, L., Gerhardt, H., Dewerchin, M., Baes, M., De Bock, K., Ghesquière, B., Lunt, S.Y., Fendt, S.M. and Carmeliet, P.
Nature 520 (7546): 192-197. 9 April 2015

Formin-mediated actin polymerization at endothelial junctions is required for vessel lumen formation and stabilization.
Phng, L.K., Gebala, V., Bentley, K., Philippides, A., Wacker, A., Mathivet, T., Sauteur, L., Stanchi, F., Belting, H.G., Affolter, M. and Gerhardt, H.
Developmental Cell 32 (1): 123-132. 12 January 2015

The endothelial transcription factor ERG promotes vascular stability and growth through Wnt/β-catenin signaling.
Birdsey, G.M., Shah, A.V., Dufton, N., Reynolds, L.E., Osuna Almagro, L., Yang, Y., Aspalter, I.M., Khan, S.T., Mason, J.C., Dejana, E., Göttgens, B., Hodivala-Dilke, K., Gerhardt, H., Adams, R.H. and Randi, A.M.
Developmental Cell 32 (1): 82-96. 12 January 2015

Quantitative assessment of angiogenesis, perfused blood vessels and endothelial tip cells in the postnatal mouse brain.
Wälchli, T., Mateos, J.M., Weinman, O., Babic, D., Regli, L., Hoerstrup, S.P., Gerhardt, H., Schwab, M.E. and Vogel, J.
Nature Protocols 10 (1): 53-74. January 2015

2014

Lack of CCM1 induces hypersprouting and impairs response to flow.
Mleynek, T.M., Chan, A.C., Redd, M., Gibson, C.C., Davis, C.T., Shi, D.S., Chen, T., Carter, K.L., Ling, J., Blanco, R., Gerhardt, H., Whitehead, K. and Li, D.Y.
Human Molecular Genetics 23 (23): 6223-6234. 1 December 2014

Computer simulations reveal complex distribution of haemodynamic forces in a mouse retina model of angiogenesis.
Bernabeu, M.O., Jones, M.L., Nielsen, J.H., Krüger, T., Nash, R.W., Groen, D., Schmieschek, S., Hetherington, J., Gerhardt, H., Franco, C.A. and Coveney, P.V.
Journal of the Royal Society Interface 11 (99): 20140543. 6 October 2014

Tumor vessel normalization by chloroquine independent of autophagy.
Maes, H., Kuchnio, A., Peric, A., Moens, S., Nys, K., De Bock, K., Quaegebeur, A., Schoors, S., Georgiadou, M., Wouters, J., Vinckier, S., Vankelecom, H., Garmyn, M., Vion, A.C., Radtke, F., Boulanger, C., Gerhardt, H., Dejana, E., Dewerchin, M., Ghesquière, B., Annaert, W., Agostinis, P. and Carmeliet, P.
Cancer Cell 26 (2): 190-206. 11 August 2014

Tissue guidance without filopodia.
Wacker, A., Gerhardt, H. and Phng, L.K.
Communicative & Integrative Biology 7 (1): e28820. 9 April 2014

The role of differential VE-cadherin dynamics in cell rearrangement during angiogenesis.
Bentley, K., Franco, C.A., Philippides, A., Blanco, R., Dierkes, M., Gebala, V., Stanchi, F., Jones, M., Aspalter, I.M., Cagna, G., Weström, S., Claesson-Welsh, L., Vestweber, D. and Gerhardt, H.
Nature Cell Biology 16 (4): 309-321. April 2014

Glioma-derived galectin-1 regulates innate and adaptive antitumor immunity.
Verschuere, T., Toelen, J., Maes, W., Poirier, F., Boon, L., Tousseyn, T., Mathivet, T., Gerhardt, H., Mathieu, V., Kiss, R., Lefranc, F., Van Gool, S.W. and De Vleeschouwer, S.
International Journal of Cancer 134 (4): 873-884. 15 February 2014

Partial and transient reduction of glycolysis by PFKFB3 blockade reduces pathological angiogenesis.
Schoors, S., De Bock, K., Cantelmo, A.R., Georgiadou, M., Ghesquière, B., Cauwenberghs, S., Kuchnio, A., Wong, B.W., Quaegebeur, A., Goveia, J., Bifari, F., Wang, X., Blanco, R., Tembuyser, B., Cornelissen, I., Bouché, A., Vinckier, S., Diaz-Moralli, S., Gerhardt, H., Telang, S., Cascante, M., Chesney, J., Dewerchin, M. and Carmeliet, P.
Cell Metabolism 19 (1): 37-48. 7 January 2014

Crim1 maintains retinal vascular stability during development by regulating endothelial cell Vegfa autocrine signaling.
Fan, J., Ponferrada, V.G., Sato, T., Vemaraju, S., Fruttiger, M., Gerhardt, H., Ferrara, N. and Lang, R. A.
Development 141 (2): 448-459. January 2014

2013

Filopodia are dispensable for endothelial tip cell guidance.
Phng, L.K., Stanchi, F. and Gerhardt, H.
Development 140 (19): 4031-4040. October 2013

Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis.
Soler, A., Serra, H., Pearce, W., Angulo, A., Guillermet-Guibert, J., Friedman, L.S., Viñals, F., Gerhardt, H., Casanovas, O., Graupera, M. and Vanhaesebroeck, B.
Journal of Experimental Medicine 210 (10): 1937-1945. 23 September 2013

PP2A regulatory subunit Bα controls endothelial contractility and vessel lumen integrity via regulation of HDAC7.
Martin, M., Geudens, I., Bruyr, J., Potente, M., Bleuart, A., Lebrun, M., Simonis, N., Deroanne, C., Twizere, J.C., Soubeyran, P., Peixoto, P., Mottet, D., Janssens, V., Hofmann, W.K., Claes, F., Carmeliet, P., Kettmann, R., Gerhardt, H. and Dequiedt, F.
EMBO Journal 32 (18): 2491-2503. 11 September 2013

Role of PFKFB3-driven glycolysis in vessel sprouting.
De Bock, K., Georgiadou, M., Schoors, S., Kuchnio, A., Wong, B.W., Cantelmo, A.R., Quaegebeur, A., Ghesquière, B., Cauwenberghs, S., Eelen, G., Phng, L.K., Betz, I., Tembuyser, B., Brepoels, K., Welti, J., Geudens, I., Segura, I., Cruys, B., Bifari, F., Decimo, I., Blanco, R., Wyns, S., Vangindertael, J., Rocha, S., Collins, R.T., Munck, S., Daelemans, D., Imamura, H., Devlieger, R., Rider, M., Van Veldhoven, P.P., Schuit, F., Bartrons, R., Hofkens, J., Fraisl, P., Telang, S., DeBerardinis, R.J., Schoonjans, L., Vinckier, S., Chesney, J., Gerhardt, H., Dewerchin, M. and Carmeliet, P.
Cell 154 (3): 651-663. 1 August 2013

SRF selectively controls tip cell invasive behavior in angiogenesis.
Franco, C.A., Blanc, J., Parlakian, A., Blanco, R., Aspalter, I.M., Kazakova, N., Diguet, N., Mylonas, E., Gao-Li, J., Vaahtokari, A., Penard-Lacronique, V., Fruttiger, M., Rosewell, I., Mericskay, M., Gerhardt, H. and Li, Z.
Development 140 (11): 2321-2333. June 2013

Introduction to the ECR special angiogenesis issue.
Claesson-Welsh, L. and Gerhardt, H.
Experimental Cell Research 319 (9): 1239. 15 May 2013

A truncation allele in vascular endothelial growth factor c reveals distinct modes of signaling during lymphatic and vascular development.
Villefranc, J.A., Nicoli, S., Bentley, K., Jeltsch, M., Zarkada, G., Moore, J.C., Gerhardt, H., Alitalo, K. and Lawson, N.D.
Development 140 (7): 1497-1506. April 2013

VEGF and Notch in tip and stalk cell selection.
Blanco, R. and Gerhardt, H.
Cold Spring Harbor Perspectives in Medicine 3 (1): a006569. 1 January 2013

2012

Visualization of endothelial actin cytoskeleton in the mouse retina.
Fraccaroli, A., Franco, C.A., Rognoni, E., Neto, F., Rehberg, M., Aszodi, A., Wedlich-Söldner, R., Pohl, U., Gerhardt, H. and Montanez, E.
PLoS ONE 7 (10): e47488. 24 October 2012

Tissue engineering: Blood vessels on a chip.
Franco, C. and Gerhardt, H.
Nature 488 (7412): 465-466. 23 August 2012

Kidins220/ARMS mediates the integration of the neurotrophin and VEGF pathways in the vascular and nervous systems.
Cesca, F., Yabe, A., Spencer-Dene, B., Scholz-Starke, J., Medrihan, L., Maden, C.H., Gerhardt, H., Orriss, I.R., Baldelli, P., Al-Qatari, M., Koltzenburg, M., Adams, R.H., Benfenati, F. and Schiavo, G.
Cell Death and Differentiation 19 (2): 194-208. February 2012

2011

Endothelial development taking shape.
Wacker, A. and Gerhardt, H.
Current Opinion in Cell Biology 23 (6): 676-685. December 2011

Endothelial basement membrane limits tip cell formation by inducing Dll4/Notch signalling in vivo.
Stenzel, D., Franco, C.A., Estrach, S., Mettouchi, A., Sauvaget, D., Rosewell, I., Schertel, A., Armer, H., Domogatskaya, A., Rodin, S., Tryggvason, K., Collinson, L., Sorokin, L. and Gerhardt, H.
EMBO Reports 12 (11): 1135-1143. 1 November 2011

Coordinating cell behaviour during blood vessel formation.
Geudens, I. and Gerhardt, H.
Development 138 (21): 4569-4583. November 2011

N-CAM exhibits a regulatory function in pathological angiogenesis in oxygen induced retinopathy.
Håkansson, J., Ståhlberg, A., Wolfhagen Sand, F., Gerhardt, H. and Semb, H.
PLoS ONE 6 (10): e26026. 17 October 2011

Integrin-dependent and -independent functions of astrocytic fibronectin in retinal angiogenesis.
Stenzel, D., Lundkvist, A., Sauvaget, D., Busse, M., Graupera, M., van der Flier, A., Wijelath, E.S., Murray, J., Sobel, M., Costell, M., Takahashi, S., Fässler, R., Yamaguchi, Y., Gutmann, D.H., Hynes, R.O. and Gerhardt, H.
Development 138 (20): 4451-4463. 15 October 2011

Basic and therapeutic aspects of angiogenesis.
Potente, M., Gerhardt, H. and Carmeliet, P.
Cell 146 (6): 873-887. 16 September 2011

VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling.
Tammela, T., Zarkada, G., Nurmi, H., Jakobsson, L., Heinolainen, K., Tvorogov, D., Zheng, W., Franco, C.A., Murtomäki, A., Aranda, E., Miura, N., Ylä-Herttuala, S., Fruttiger, M., Mäkinen, T., Eichmann, A., Pollard, J.W., Gerhardt, H. and Alitalo, K.
Nature Cell Biology 13 (10): 1202-1213. 11 September 2011

Laminin-binding integrins induce Dll4 expression and Notch signaling in endothelial cells.
Estrach, S., Cailleteau, L., Franco, C.A., Gerhardt, H., Stefani, C., Lemichez, E., Gagnoux-Palacios, L., Meneguzzi, G. and Mettouchi, A.
Circulation Research 109 (2): 172-182. 8 July 2011

Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells.
Stefater, J.A., Lewkowich, I., Rao, S., Mariggi, G., Carpenter, A.C., Burr, A.R., Fan, J., Ajima, R., Molkentin, J.D., Williams, B.O., Wills-Karp, M., Pollard, J.W., Yamaguchi, T., Ferrara, N., Gerhardt, H. and Lang, R.A.
Nature 474 (7352): 511-515. 23 June 2011

Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase.
Guarani, V., Deflorian, G., Franco, C.A., Krüger, M., Phng, L.K., Bentley, K., Toussaint, L., Dequiedt, F., Mostoslavsky, R., Schmidt, M.H.H., Zimmermann, B., Brandes, R.P., Mione, M., Westphal, C.H., Braun, T., Zeiher, A.M., Gerhardt, H., Dimmeler, S. and Potente, M.
Nature 473 (7346): 234-238. 12 May 2011

A two-way communication between microglial cells and angiogenic sprouts regulates angiogenesis in aortic ring cultures.
Rymo, S.F., Gerhardt, H., Wolfhagen Sand, F., Lang, R., Uv, A. and Betsholtz, C.
PLoS ONE 6 (1): e15846. 10 January 2011

2010

Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting.
Jakobsson, L., Franco, C.A., Bentley, K., Collins, R.T., Ponsioen, B., Aspalter, I.M., Rosewell, I., Busse, M., Thurston, G., Medvinsky, A., Schulte-Merker, S. and Gerhardt, H.
Nature Cell Biology 12 (10): 943-953. October 2010

Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish.
Geudens, I., Herpers, R., Hermans, K., Segura, I., Ruiz de Almodovar, C., Bussmann, J., De Smet, F., Vandevelde, W., Hogan, B.M., Siekmann, A., Claes, F., Moore, J.C., Pistocchi, A.S., Loges, S., Mazzone, M., Mariggi, G., Bruyère, F., Cotelli, F., Kerjaschki, D., Noël, A., Foidart, J.M., Gerhardt, H., Ny, A., Langenberg, T., Lawson, N.D., Duckers, H.J., Schulte-Merker, S., Carmeliet, P. and Dewerchin, M.
Arteriosclerosis Thrombosis and Vascular Biology 30 (9): 1695-1702. September 2010

2009

Cyclic Nrarp mRNA expression is regulated by the somitic oscillator but Nrarp protein levels do not oscillate.
Wright, D., Ferjentsik, Z., Chong, S.W., Qiu, X., Yun-Jin, J., Malapert, P., Pourquié, O., Van Hateren, N., Wilson, S.A., Franco, C., Gerhardt, H., Dale, J.K. and Maroto, M.
Developmental Dynamics 238 (12): 3043-3055. December 2009

VEGFRs and Notch: a dynamic collaboration in vascular patterning.
Jakobsson, L., Bentley, K. and Gerhardt, H.
Biochemical Society Transactions 37 (Pt 6): 1233-1236. December 2009

Imaging transient blood vessel fusion events in zebrafish by correlative volume electron microscopy.
Armer, H.E.J., Mariggi, G., Png, K.M.Y., Genoud, C., Monteith, A.G., Bushby, A.J., Gerhardt, H. and Collinson, L.M.
PLoS ONE 4 (11): e7716. 6 November 2009

Tipping the balance: robustness of tip cell selection, migration and fusion in angiogenesis.
Bentley, K., Mariggi, G., Gerhardt, H. and Bates, P.A.
PLoS Computational Biology 5 (10): e1000549. 30 October 2009

Vascular morphogenesis: a Wnt for every vessel?
Franco, C.A., Liebner, S. and Gerhardt, H.
Current Opinion in Genetics & Development 19 (5): 476-483. October 2009

Peripheral mural cell recruitment requires cell-autonomous heparan sulfate.
Stenzel, D., Nye, E., Nisancioglu, M., Adams, R.H., Yamaguchi, Y. and Gerhardt, H.
Blood 114 (4): 915-924. 23 July 2009

Angiogenesis: a team effort coordinated by notch.
Phng, L.K. and Gerhardt, H.
Developmental Cell 16 (2): 196-208. 17 February 2009

Nrarp coordinates endothelial Notch and Wnt signaling to control vessel density in angiogenesis.
Phng, L.K., Potente, M., Leslie, J.D., Babbage, J., Nyqvist, D., Lobov, I., Ondr, J.K., Rao, S., Lang, R.A., Thurston, G. and Gerhardt, H.
Developmental Cell 16 (1): 70-82. 20 January 2009

2008

Wnt/β-catenin signaling controls development of the blood-brain barrier.
Liebner, S., Corada, M., Bangsow, T., Babbage, J., Taddei, A., Czupalla, C.J., Reis, M., Felici, A., Wolburg, H., Fruttiger, M., Taketo, M.M., von Melchner, H., Plate, K.H., Gerhardt, H. and Dejana, E.
Journal of Cell Biology 183 (3): 409-417. 3 November 2008

Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice.
Fu, J., Gerhardt, H., McDaniel, J.M., Xia, B., Liu, X., Ivanciu, L., Ny, A., Hermans, K., Silasi-Mansat, R., McGee, S., Nye, E., Ju, T., Ramirez, M.I., Carmeliet, P., Cummings, R.D., Lupu, F. and Xia, L.
Journal of Clinical Investigation 118 (11): 3725-3737. November 2008

VEGF and endothelial guidance in angiogenic sprouting.
Gerhardt, H.
Organogenesis 4 (4): 241-246. October 2008

Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migration.
Graupera, M., Guillermet-Guibert, J., Foukas, L.C., Phng, L.K., Cain, R.J., Salpekar, A., Pearce, W., Meek, S., Millan, J., Cutillas, P.R., Smith, A.J.H., Ridley, A.J., Ruhrberg, C., Gerhardt, H. and Vanhaesebroeck, B.
Nature 453 (7195): 662-666. 29 May 2008

Dendritic cell expression of the Notch ligand jagged2 is not essential for Th2 response induction in vivo.
Worsley, A.G.F., LeibundGut-Landmann, S., Slack, E., Phng, L.K., Gerhardt, H., Reis e Sousa, C. and MacDonald, A.S.
European Journal of Immunology 38 (4): 1043-1049. April 2008

Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability.
Jones, C.A., London, N.R., Chen, H., Park, K.W., Sauvaget, D., Stockton, R.A., Wythe, J.D., Suh, W., Larrieu-Lahargue, F., Mukouyama, Y.S., Lindblom, P., Seth, P., Frias, A., Nishiya, N., Ginsberg, M.H., Gerhardt, H., Zhang, K. and Li, D.Y.
Nature Medicine 14 (4): 448-453. April 2008

Therapeutic antibodies targeting angiomotin inhibit angiogenesis in vivo.
Levchenko, T., Veitonmäki, N., Lundkvist, A., Gerhardt, H., Ming, Y., Berggren, K., Kvanta, A., Carlsson, R. and Holmgren, L.
FASEB Journal 22 (3): 880-889. March 2008

Pericytes: gatekeepers in tumour cell metastasis?
Gerhardt, H. and Semb, H.
Journal of Molecular Medicine 86 (2): 135-144. February 2008

Agent-based simulation of notch-mediated tip cell selection in angiogenic sprout initialisation.
Bentley, K., Gerhardt, H. and Bates, P.A.
Journal of Theoretical Biology 250 (1): 25-36. 7 January 2008

2007

Growth factor gradients in vascular patterning.
Lundkvist, A., Lee, S., Iruela-Arispe, L., Betsholtz, C. and Gerhardt, H.
Novartis Foundation Symposium 283 : 194-201. 20 July 2007

VEGF and Notch signaling: the yin and yang of angiogenic sprouting.
Hellström, M., Phng, L.K. and Gerhardt, H.
Cell Adhesion & Migration 1 (3): 133-136. July 2007

Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis.
Hellström, M., Phng, L.K., Hofmann, J.J., Wallgard, E., Coultas, L., Lindblom, P., Alva, J., Nilsson, A.K., Karlsson, L., Gaiano, N., Yoon, K., Rossant, J., Iruela-Arispe, M.L., Kalén, M., Gerhardt, H. and Betsholtz, C.
Nature 445 (7129): 776-780. 15 February 2007

Defective N-sulfation of heparan sulfate proteoglycans limits PDGF-BB binding and pericyte recruitment in vascular development.
Abramsson, A., Kurup, S., Busse, M., Yamada, S., Lindblom, P., Schallmeiner, E., Stenzel, D., Sauvaget, D., Ledin, J., Ringvall, M., Landegren, U., Kjellén, L., Bondjers, G., Li, J.P., Lindahl, U., Spillmann, D., Betsholtz, C. and Gerhardt, H.
Genes & Development 21 (3): 316-331. 1 February 2007

2006

Unique vascular phenotypes following over-expression of individual VEGFA isoforms from the developing lens.
Mitchell, C.A., Rutland, C.S., Walker, M., Nasir, M., Foss, A.J.E., Stewart, C., Gerhardt, H., Konerding, M.A., Risau, W. and Drexler, H.C.A.
Angiogenesis 9 (4): 209-224. December 2006

Heparan sulphate requirement in platelet-derived growth factor B-mediated pericyte recruitment.
Kurup, S., Abramsson, A., Li, J.P., Lindahl, U., Kjellen, L., Betsholtz, C., Gerhardt, H. and Spillmann, D.
Biochemical Society Transactions 34 (3): 454-455. 1 June 2006

Pericytes limit tumor cell metastasis.
Xian, X., Håkansson, J., Ståhlberg, A., Lindblom, P., Betsholtz, C., Gerhardt, H. and Semb, H.
Journal of Clinical Investigation 116 (3): 642-651. 1 March 2006

2005

How do endothelial cells orientate?
Gerhardt, H. and Betsholtz, C.
Experientia Supplementum 94 : 3-15. 2005

Role of pericytes in vascular morphogenesis.
Betsholtz, C., Lindblom, P. and Gerhardt, H.
Experientia Supplementum 94 : 115-125. 2005

2004

Neuropilin-1 is required for endothelial tip cell guidance in the developing central nervous system.
Gerhardt, H., Ruhrberg, C., Abramsson, A., Fujisawa, H., Shima, D. and Betsholtz, C.
Developmental Dynamics 231 (3): 503-509. November 2004

Role of platelet-derived growth factor in mesangium development and vasculopathies: lessons from platelet-derived growth factor and platelet-derived growth factor receptor mutations in mice.
Betsholtz, C., Lindblom, P., Bjarnegard, M., Enge, M., Gerhardt, H. and Lindahl, P.
Current Opinion in Nephrology and Hypertension 13 (1): 45-52. January 2004

2003

Cortical and retinal defects caused by dosage-dependent reductions in VEGF-A paracrine signaling.
Haigh, J.J., Morelli, P.I., Gerhardt, H., Haigh, K., Tsien, J., Damert, A., Miquerol, L., Muhlner, U., Klein, R., Ferrara, N., Wagner, E.F., Betsholtz, C. and Nagy, A.
Developmental Biology 262 (2): 225-241. 15 October 2003

Endothelial-pericyte interactions in angiogenesis.
Gerhardt, H. and Betsholtz, C.
Cell and Tissue Research 314 (1): 15-23. October 2003

Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall.
Lindblom, P., Gerhardt, H., Liebner, S., Abramsson, A., Enge, M., Hellstrom, M., Backstrom, G., Fredriksson, S., Landegren, U., Nystrom, H.C., Bergstrom, G., Dejana, E., Ostman, A., Lindahl, P. and Betsholtz, C.
Genes & Development 17 (15): 1835-1840. 1 August 2003

VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia.
Gerhardt, H., Golding, M., Fruttiger, M., Ruhrberg, C., Lundkvist, A., Abramsson, A., Jeltsch, M., Mitchell, C., Alitalo, K., Shima, D. and Betsholtz, C.
Journal of Cell Biology 161 (6): 1163-1177. 23 June 2003

2002

Defective associations between blood vessels and brain parenchyma lead to cerebral hemorrhage in mice lacking αv integrins.
McCarty, J.H., Monahan-Earley, R.A., Brown, L.F., Keller, M., Gerhardt, H., Rubin, K., Shani, M., Dvorak, H.F., Wolburg, H., Bader, B.L., Dvorak, A.M. and Hynes, R.O.
Molecular and Cellular Biology 22 (21): 7667-7677. November 2002

Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis.
Ruhrberg, C., Gerhardt, H., Golding, M., Watson, R., Ioannidou, S., Fujisawa, H., Betsholtz, C. and Shima, D.T.
Genes & Development 16 (20): 2684-2698. 15 October 2002

A new method for large scale isolation of kidney glomeruli from mice.
Takemoto, M., Asker, N., Gerhardt, H., Lundkvist, A., Johansson, B.R., Saito, Y. and Betsholtz, C.
American Journal of Pathology 161 (3): 799-805. September 2002

Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy.
Enge, M., Bjarnegård, M., Gerhardt, H., Gustafsson, E., Kalén, M., Asker, N., Hammes, H.-P., Shani, M., Fässler, R. and Betsholtz, C.
EMBO Journal 21 (16): 4307-4316. 15 August 2002

2001

Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis.
Hellström, M., Gerhardt, H., Kalén, M., Li, X., Eriksson, U., Wolburg, H. and Betsholtz, C.
Journal of Cell Biology 153 (3): 543-553. 30 April 2001

2000

Localization of Legionella bacteria within ribosome-studded phagosomes is not restricted to Legionella pneumophila.
Gerhardt, H., Walz, M.J., Faigle, M., Northoff, H., Wolburg, H. and Neumeister, B.
FEMS Microbiology Letters 192 (1): 145-152. 1 November 2000

R- and B-cadherin expression defines subpopulations of glial cells involved in axonal guidance in the optic nerve head of the chicken.
Gerhardt, H., Rascher, G., Schuck, J., Weigold, U., Redies, C. and Wolburg, H.
Glia 31 (2): 131-143. August 2000

The peripapillary glia of the optic nerve head in the chicken retina.
Schuck, J., Gerhardt, H. and Wolburg, H.
Anatomical Record 259 (3): 263-275. 1 July 2000

N-cadherin mediates pericytic-endothelial interaction during brain angiogenesis in the chicken.
Gerhardt, H., Wolburg, H. and Redies, C.
Developmental Dynamics 218 (3): 472-479. July 2000

Differential expression of endothelial β-catenin and plakoglobin during development and maturation of the blood-brain and blood-retina barrier in the chicken.
Liebner, S., Gerhardt, H. and Wolburg, H.
Developmental Dynamics 217 (1): 86-98. January 2000

Legionella species of different human prevalence induce different rates of apoptosis in human monocytic cells.
Walz, J.M., Gerhardt, H., Faigle, M., Wolburg, H. and Neumeister, B.
APMIS 108 (6): 398-408. January 2000

1999

Differentiation of a unique macroglial cell type in the pecten oculi of the chicken.
Gerhardt, H., Schuck, J. and Wolburg, H.
Glia 28 (3): 201-214. December 1999

N-cadherin expression in endothelial cells during early angiogenesis in the eye and brain of the chicken: relation to blood-retina and blood-brain barrier development.
Gerhardt, H., Liebner, S., Redies, C. and Wolburg, H.
European Journal of Neuroscience 11 (4): 1191-1201. April 1999

Ultrastructural localization of adhesion molecules in the healthy and inflamed choroid plexus of the mouse.
Wolburg, K., Gerhardt, H., Schulz, M., Wolburg, H. and Engelhardt, B.
Cell and Tissue Research 296 (2): 259-269. April 1999

The pecten oculi of the chicken: a model system for vascular differentiation and barrier maturation.
Wolburg, H., Liebner, S., Reichenbach, A. and Gerhardt, H.
International Review of Cytology 187 : 111-159. 1999

1997

Maturation of the blood-retina barrier in the developing pecten oculi of the chicken.
Liebner, S., Gerhardt, H. and Wolburg, H.
Brain Research Developmental Brain Research 100 (2): 205-219. 18 June 1997

1996

The pecten oculi of the chicken as a new in vivo model of the blood-brain barrier.
Gerhardt, H., Liebner, S. and Wolburg, H.
Cell and Tissue Research 285 (1): 91-100. June 1996