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Mesothelial-mesenchymal transitions in embryogenesis

Item Type:Review
Title:Mesothelial-mesenchymal transitions in embryogenesis
Creators Name:Carmona, R., Ariza, L., Cano, E., Jiménez-Navarro, M. and Muñoz-Chápuli, R.
Abstract:Most animals develop coelomic cavities lined by an epithelial cell layer called the mesothelium. Embryonic mesothelial cells have the ability to transform into mesenchymal cells which populate many developing organs contributing to their connective and vascular tissues, and also to organ-specific cell types. Furthermore, embryonic mesothelium and mesothelial-derived cells produce essential signals for visceral morphogenesis. We review the most relevant literature about the mechanisms regulating the embryonic mesothelial-mesenchymal transition, the developmental fate of the mesothelial-derived cells and other functions of the embryonic mesothelium, such as its contribution to the establishment of left-right visceral asymmetries or its role in limb morphogenesis.
Keywords:Mesothelium, Coelomic Epithelium, Epithelial-Mesenchymal Transition, Organogenesis, Animals
Source:Seminars in Cell & Developmental Biology
Publisher:Elsevier / Academic Press
Page Range:37-44
Date:August 2019
Official Publication:https://doi.org/10.1016/j.semcdb.2018.09.006
PubMed:View item in PubMed

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