Helmholtz Gemeinschaft


Coordinating cell behaviour during blood vessel formation

Item Type:Review
Title:Coordinating cell behaviour during blood vessel formation
Creators Name:Geudens, I. and Gerhardt, H.
Abstract:The correct development of blood vessels is crucial for all aspects of tissue growth and physiology in vertebrates. The formation of an elaborate hierarchically branched network of endothelial tubes, through either angiogenesis or vasculogenesis, relies on a series of coordinated morphogenic events, but how individual endothelial cells adopt specific phenotypes and how they coordinate their behaviour during vascular patterning is unclear. Recent progress in our understanding of blood vessel formation has been driven by advanced imaging techniques and detailed analyses that have used a combination of powerful in vitro, in vivo and in silico model systems. Here, we summarise these models and discuss their advantages and disadvantages. We then review the different stages of blood vessel development, highlighting the cellular mechanisms and molecular players involved at each step and focusing on cell specification and coordination within the network.
Keywords:Angiogenic Sprouting, Model Systems, Vascular Network, Angiogenesis, Animals
Publisher:Company of Biologists
Page Range:4569-4583
Date:November 2011
Official Publication:https://doi.org/10.1242/dev.062323
PubMed:View item in PubMed

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