2024
A phase I study of MAGE-A1-targeted T1367 T-cell receptor-based cell therapy in patients with advanced multiple myeloma.
Krüger, J., Obenaus, M., Blau, I.W., Hoser, D., Vaegler, M., Rauschenbach, H., Anagnostopoulos, I., Jöhrens, K., Scheuplein, V., Kieback, E., Böhme, J., Von Brünneck, A.C., Krönke, J., Busse, A., Willimsky, G., Blankenstein, T., Pezzutto, A., Keller, U. and Nogai, A.
Haematologica
12 September 2024
(In Press)
Oncogene inactivation-induced senescence facilitates tumor relapse.
Schmitt, P., Hönig, K., Milojkovic, A., Anders, K., Schröck, E., Sauer, S., Uyar, B., Akalin, A., Martínez-Reyes, I. and Blankenstein, T.
bioRxiv
: 2024.07.13.603369.
17 July 2024
Virus-reactive T cells expanded in aplastic anemia eliminate hematopoietic progenitor cells by molecular mimicry.
Ben Hamza, A., Welters, C., Stadler, S., Brüggemann, M., Dietze, K., Brauns, O., Brümmendorf, T.H., Winkler, T.H., Bullinger, L., Blankenstein, T., Rosenberger, L., Leisegang, M., Kammertöns, T., Herr, W., Moosmann, A., Strobel, J., Hackstein, H., Dornmair, K., Beier, F. and Hansmann, L.
Blood 143
(14): 1365-1378.
4 April 2024
HLA-C*04:09N is expressed at the cell surface and triggers peptide-specific T-cell activation.
Welters, C., Welters, M.L., Stadler, S., Bullinger, L., Strobel, J., Hackstein, H., Dhamodaran, A., Blankenstein, T. and Hansmann, L.
Haematologica 109
(4): 1121-1127.
April 2024
2023
Response to: Correspondence on 'H3.3K27M mutation is not a suitable target for immunotherapy in HLA-A2+ patients with diffuse midline glioma' by Chheda et al.
Immisch, L., Papafotiou, G., Popp, O., Mertins, P., Blankenstein, T. and Willimsky, G.
Journal for ImmunoTherapy of Cancer 11
(3): e006784.
14 March 2023
IFNγ binding to extracellular matrix prevents fatal systemic toxicity.
Kemna, J., Gout, E., Daniau, L., Lao, J., Weißert, K., Ammann, S., Kühn, R., Richter, M., Molenda, C., Sporbert, A., Zocholl, D., Klopfleisch, R., Schütz, A., Lortat-Jacob, H., Aichele, P., Kammertoens, T. and Blankenstein, T.
Nature Immunology 24
(3): 414-422.
March 2023
Targeting the recurrent Rac1P29S neoepitope in melanoma with heterologous high-affinity T cell receptors.
Immisch, L., Papafotiou, G., Gallarín Delgado, N., Scheuplein, V., Paschen, A., Blankenstein, T. and Willimsky, G.
Frontiers in Immunology 14
: 1119498.
16 February 2023
Diverse effects of obesity on antitumor immunity and immunotherapy.
Dyck, L. and Lynch, L.
Trends in Molecular Medicine 29
(2): 112-123.
February 2023
Generation of TGFβR2(-1) neoantigen-specific HLA-DR4-restricted T cell receptors for cancer therapy.
Plewa, N., Poncette, L. and Blankenstein, T.
Journal for ImmunoTherapy of Cancer 11
(2): e006001.
February 2023
2022
Immune phenotypes and target antigens of clonally expanded bone marrow T cells in treatment-naïve multiple myeloma.
Welters, C., Lammoglia Cobo, M.F., Stein, C.A., Hsu, M.T., Ben Hamza, A., Penter, L., Chen, X., Buccitelli, C., Popp, O., Mertins, P., Dietze, K., Bullinger, L., Moosmann, A., Blanc, E., Beule, D., Gerbitz, A., Strobel, J., Hackstein, H., Rahn, H.P., Dornmair, K., Blankenstein, T. and Hansmann, L.
Cancer Immunology Research 10
(11): 1407-1419.
1 November 2022
H3.3K27M mutation is not a suitable target for immunotherapy in HLA-A2(+) patients with diffuse midline glioma.
Immisch, L., Papafotiou, G., Popp, O., Mertins, P., Blankenstein, T. and Willimsky, G.
Journal for ImmunoTherapy of Cancer 10
(10): e005535.
27 October 2022
Editorial: Mitochondria as a hub in cellular signaling.
Stoolman, J.S., Porcelli, A.M. and Martínez-Reyes, I.
Frontiers in Cell and Developmental Biology 10
: 981464.
15 August 2022
Rapid single-cell identification of Epstein-Barr virus-specific T-cell receptors for cellular therapy.
Lammoglia Cobo, M.F., Welters, C., Rosenberger, L., Leisegang, M., Dietze, K., Pircher, C., Penter, L., Gary, R., Bullinger, L., Takvorian, A., Moosmann, A., Dornmair, K., Blankenstein, T., Kammertöns, T., Gerbitz, A. and Hansmann, L.
Cytotherapy 24
(8): 818-826.
August 2022
IFN-γ-dependent tumor-antigen cross-presentation by lymphatic endothelial cells promotes their killing by T cells and inhibits metastasis.
Garnier, L., Pick, R., Montorfani, J., Sun, M., Brighouse, D., Liaudet, N., Kammertoens, T., Blankenstein, T., Page, N., Bernier-Latamani, J., Tran, N.L., Petrova, T.V., Merkler, D., Scheiermann, C. and Hugues, S.
Science Advances 8
(23): eabl5162.
8 June 2022
Isolation of neoantigen-specific human T cell receptors from different human and murine repertoires.
Grunert, C., Willimsky, G., Peuker, C.A., Rhein, S., Hansmann, L., Blankenstein, T., Blanc, E., Beule, D., Keller, U., Pezzutto, A. and Busse, A.
Cancers 14
(7): 1842.
6 April 2022
The role of CD4 T cells in rejection of solid tumors.
Poncette, L., Bluhm, J. and Blankenstein, T.
Current Opinion in Immunology 74
: 18-24.
February 2022
2021
Long-term in vitro expansion ensures increased yield of central memory T cells as perspective for manufacturing challenges.
Herda, S., Heimann, A., Obermayer, B., Ciraolo, E., Althoff, S., Ruß, J., Grunert, C., Busse, A., Bullinger, L., Pezzutto, A., Blankenstein, T., Beule, D. and Na, I.K.
International Journal of Cancer 148
(12): 3097-3110.
15 June 2021
Thyrotropin receptor-specific lymphocytes in adenovirus-TSHR-immunized native and human leukocyte antigen-DR3-transgenic mice and in Graves' disease patient blood.
Degen, H., Gavvovidis, I., Blankenstein, T., Uhland, K. and Ungerer, M.
Thyroid 31
(6): 950-963.
June 2021
In vitro proteasome processing of neo-splicetopes does not predict their presentation in vivo.
Willimsky, G., Beier, C., Immisch, L., Papafotiou, G., Scheuplein-Schlosser, V., Goede, A., Holzhütter, H.G., Blankenstein, T. and Kloetzel, P.M.
eLife 10
: e62019.
20 April 2021
CD28 co-stimulus achieves superior CAR T cell effector function against solid tumors than 4-1BB co-stimulus.
Textor, A., Grunewald, L., Anders, K., Klaus, A., Schwiebert, S., Winkler, A., Stecklum, M., Rolff, J., Henssen, A.G., Höpken, U.E., Eggert, A., Schulte, J.H., Jensen, M.C., Blankenstein, T. and Künkele, A.
Cancers 13
(5): 1050.
2 March 2021
2020
Early life stress regulates cardiac development through an IL4-glucocorticoid signaling balance.
Apaydin, D.C., Jaramillo, P.A.M., Corradi, L., Cosco, F., Rathjen, F.G., Kammertoens, T., Filosa, A. and Sawamiphak, S.
Cell Reports 33
(7): 108404.
17 November 2020
Stress hormones or general well-being are not altered in immune-deficient mice lacking either T- and B- lymphocytes or Interferon gamma signaling if kept under specific pathogen free housing conditions.
Jeuthe, S., Kemna, J., Kemna, C.P., Zocholl, D., Klopfleisch, R., Palme, R., Kirschbaum, C., Thoene-Reineke, C. and Kammertoens, T.
PLoS ONE 15
(9): e0239231.
30 September 2020
"Designer cytokines" targeting the tumor vasculature - think global and act local.
Kammertoens, T., Kemna, J. and Leisegang, M.
EMBO Molecular Medicine 12
(2): e11801.
7 February 2020
2019
Identification and ranking of recurrent neo-epitopes in cancer.
Blanc, E., Holtgrewe, M., Dhamodaran, A., Messerschmidt, C., Willimsky, G., Blankenstein, T. and Beule, D.
BMC Medical Genomics 12
: 171.
27 November 2019
SigsPack, a package for cancer mutational signatures.
Schumann, F., Blanc, E., Messerschmidt, C., Blankenstein, T., Busse, A. and Beule, D.
BMC Bioinformatics 20
(1): 450.
2 September 2019
High salt inhibits tumor growth by enhancing anti-tumor immunity.
Willebrand, R., Hamad, I., Van Zeebroeck, L., Kiss, M., Bruderek, K., Geuzens, A., Swinnen, D., Côrte-Real, B.F., Markó, L., Lebegge, E., Laoui, D., Kemna, J., Kammertoens, T., Brandau, S., Van Ginderachter, J.A. and Kleinewietfeld, M.
Frontiers in Immunology 10
: 1141.
4 June 2019
Intracellular expression of FLT3 in Purkinje cells: implications for adoptive T-cell therapies.
Çakmak-Görür, N., Radke, J., Rhein, S., Schumann, E., Willimsky, G., Heppner, F.L., Blankenstein, T. and Pezzutto, A.
Leukemia 33
(4): 1039-1043.
April 2019
Localization-associated immune phenotypes of clonally expanded tumor-infiltrating T cells and distribution of their target antigens in rectal cancer.
Penter, L., Dietze, K., Ritter, J., Lammoglia Cobo, M.F., Garmshausen, J., Aigner, F., Bullinger, L., Hackstein, H., Wienzek-Lischka, S., Blankenstein, T., Hummel, M., Dornmair, K. and Hansmann, L.
OncoImmunology 8
(6): e1586409.
24 March 2019
Interferon-γ receptor signaling in dendritic cells restrains spontaneous proliferation of CD4(+) T cells in chronic lymphopenic mice.
Knop, L., Frommer, C., Stoycheva, D., Deiser, K., Kalinke, U., Blankenstein, T., Kammertoens, T., Dunay, I.R. and Schüler, T.
Frontiers in Immunology 10
: 140.
7 February 2019
Effective NY-ESO-1-specific MHC II-restricted T cell receptors from antigen-negative hosts enhance tumor regression.
Poncette, L., Chen, X., Lorenz, F.K.M. and Blankenstein, T.
Journal of Clinical Investigation 129
(1): 324-335.
2 January 2019
2018
Oncogene-specific T cells fail to eradicate lymphoma-initiating B cells in mice.
Hoser, D., Schön, C., Loddenkemper, C., Lohneis, P., Kühl, A.A., Sommermann, T., Blankenstein, T. and Willimsky, G.
Blood 132
(9): 924-934.
30 August 2018
CAR T cells with enhanced sensitivity to B cell maturation antigen for the targeting of B cell non-Hodgkin's lymphoma and multiple myeloma.
Bluhm, J., Kieback, E., Marino, S.F., Oden, F., Westermann, J., Chmielewski, M., Abken, H., Uckert, W., Höpken, U.E. and Rehm, A.
Molecular Therapy 26
(8): 1906-1920.
1 August 2018
Targeting Merkel cell carcinoma by engineered T cells specific to T-antigens of Merkel cell polyomavirus.
Gavvovidis, I., Leisegang, M., Willimsky, G., Miller, N.J., Nghiem, P. and Blankenstein, T.
Clinical Cancer Research 24
(15): 3644-3655.
August 2018
ERAP1-dependent antigen cross-presentation determines efficacy of adoptive T cell therapy in mice.
Schmidt, K., Keller, C., Kühl, A.A., Textor, A., Seifert, U., Blankenstein, T., Willimsky, G. and Kloetzel, P.M.
Cancer Research 78
(12): 3243-3254.
June 2018
Efficient non-viral T cell engineering by Sleeping Beauty minicircles diminishing DNA toxicity and miRNAs silencing the endogenous TCR.
Clauss, J., Obenaus, M., Miskey, C., Ivics, Z., Izsvák, Z., Uckert, W. and Bunse, M.
Human Gene Therapy 29
(5): 569-584.
May 2018
A transgenic dual-luciferase reporter mouse for longitudinal and functional monitoring of T cells in vivo.
Szyska, M., Herda, S., Althoff, S., Heimann, A., Russ, J., D'Abundo, D., Dang, T.M., Durieux, I., Dörken, B., Blankenstein, T. and Na, I.K.
Cancer Immunology Research 6
(1): 110-120.
January 2018
2017
The immune system prevents recurrence of transplanted but not autochthonous antigenic tumors after oncogene inactivation therapy.
Anders, K., Kershaw, O., Larue, L., Gruber, A.D. and Blankenstein, T.
International Journal of Cancer 141
(12): 2551-2561.
15 December 2017
Human TCR-MHC coevolution after divergence from mice includes increased nontemplate-encoded CDR3 diversity.
Chen, X., Poncette, L. and Blankenstein, T.
Journal of Experimental Medicine 214
(11): 3417-3433.
6 November 2017
T cell receptors for clinical therapy: in vitro assessment of toxicity risk.
Kunert, A., Obenaus, M., Lamers, C.H.J., Blankenstein, T. and Debets, R.
Clinical Cancer Research 23
(20): 6012-6020.
15 October 2017
CTLA4 promotes Tyk2-STAT3 dependent B-cell oncogenecity.
Herrmann, A., Lahtz, C., Nagao, T., Song, J.Y., Chan, W.C., Lee, H., Yue, C., Look, T., Muelfarth, R., Li, W., Jenkins, K., Williams, J., Budde, L.E., Forman, S.J., Kwak, L.W., Blankenstein, T. and Yu, H.
Cancer Research 77
(18): 5118-5128.
15 September 2017
Tumour ischaemia by interferon-γ resembles physiological blood vessel regression.
Kammertoens, T., Friese, C., Arina, A., Idel, C., Briesemeister, D., Rothe, M., Ivanov, A., Szymborska, A., Patone, G., Kunz, S., Sommermeyer, D., Engels, B., Leisegang, M., Textor, A., Fehling, H.J., Fruttiger, M., Lohoff, M., Herrmann, A., Yu, H., Weichselbaum, R., Uckert, W., Hübner, N., Gerhardt, H., Beule, D., Schreiber, H. and Blankenstein, T.
Nature 545
(7652): 98-102.
4 May 2017
Recognition but no repair of abasic site in single-stranded DNA by human ribosomal uS3 protein residing within intact 40S subunit.
Grosheva, A.S., Zharkov, D.O., Stahl, J., Gopanenko, Al.V., Tupikin, A.E., Kabilov, M.R., Graifer, D.M. and Karpova, G.G.
Nucleic Acids Research 45
(7): 3833-3843.
20 April 2017
Tumor-infiltrating merkel cell polyomavirus-specific T cells are diverse and associated with improved patient survival.
Miller, N.J., Church, C.D., Dong, L., Crispin, D., Fitzgibbon, M.P., Lachance, K., Jing, L., Shinohara, M., Gavvovidis, I., Willimsky, G., McIntosh, M., Blankenstein, T., Koelle, D.M. and Nghiem, P.
Cancer Immunology Research 5
(2): 137-147.
February 2017
2016
Preventing tumor escape by targeting a post-proteasomal trimming independent epitope.
Textor, A., Schmidt, K., Kloetzel, P.M., Weißbrich, B., Perez, C., Charo, J., Anders, K., Sidney, J., Sette, A., Schumacher, T.N.M., Keller, C., Busch, D.H., Seifert, U. and Blankenstein, T.
Journal of Experimental Medicine 213
(11): 2333-2348.
17 October 2016
Interleukin-7 modulates anti-tumor CD8+ T cell responses via its action on host cells.
Deiser, K., Stoycheva, D., Bank, U., Blankenstein, T. and Schüler, T.
PLoS ONE 11
(7): e0159690.
22 July 2016
Thymus-derived regulatory T cells are positively selected on natural self-antigen through cognate interactions of high functional avidity.
Kieback, E., Hilgenberg, E., Stervbo, U., Lampropoulou, V., Shen, P., Bunse, M., Jaimes, Y., Boudinot, P., Radbruch, A., Klemm, U., Kühl, A.A., Liblau, R., Hoevelmeyer, N., Anderton, S.M., Uckert, W. and Fillatreau, S.
Immunity 44
(5): 1114-1126.
17 May 2016
Receptor combinations hone T-cell therapy.
Blankenstein, T.
Nature Biotechnology 34
(4): 389-391.
7 April 2016
Targeting human melanoma neoantigens by T cell receptor gene therapy.
Leisegang, M., Kammertoens, T., Uckert, W. and Blankenstein, T.
Journal of Clinical Investigation 126
(3): 854-858.
1 March 2016
2015
Molecular contacts of ribose-phosphate backbone of mRNA with human ribosome.
Sharifulin, D.E., Grosheva, A.S., Bartuli, Y.S., Malygin, A.A., Meschaninova, M.I., Ven'yaminova, A.G., Stahl, J., Graifer, D.M. and Karpova, G.G.
Biochimica et Biophysica Acta - Gene Regulatory Mechanisms 1849
(8): 930-939.
August 2015
Apoptosis resistance, mitotic catastrophe, and loss of ploidy control in Burkitt lymphoma.
Chumduri, C., Gillissen, B., Richter, A., Richter, A., Milojkovic, A., Overkamp, T., Mueller, A., Pott, C. and Daniel, P.T.
Journal of Molecular Medicine 93
(5): 559-572.
May 2015
Gene expression profiling of peripheral blood mononuclear cells during treatment with a gene-modified allogeneic tumor cell vaccine in advanced renal cell cancer: tumor-induced immunosuppression and a possible role for NF-κB.
Flörcken, A., Grau, M., Wolf, A., Weilemann, A., Kopp, J., Dörken, B., Blankenstein, T., Pezzutto, A., Lenz, P., Lenz, G. and Westermann, J.
International Journal of Cancer 136
(8): 1814-1826.
15 April 2015
Identification of human T-cell receptors with optimal affinity to cancer antigens using antigen-negative humanized mice.
Obenaus, M., Leitão, C., Leisegang, M., Chen, X., Gavvovidis, I., van der Bruggen, P., Uckert, W., Schendel, D.J. and Blankenstein, T.
Nature Biotechnology 33
(4): 402-407.
April 2015
Targeting cancer-specific mutations by T cell receptor gene therapy.
Blankenstein, T., Leisegang, M., Uckert, W. and Schreiber, H.
Current Opinion in Immunology 33
: 112-119.
April 2015
Visceral leishmaniasis diagnosis and reporting delays as an obstacle to timely response actions in Nepal and India.
Boettcher, J.P., Siwakoti, Y., Milojkovic, A., Siddiqui, N.A., Gurung, C.K., Rijal, S., Das, P., Kroeger, A. and Banjara, M.R.
BMC Infectious Diseases 15
(1): 43.
6 February 2015
MHCII-independent CD4(+) T cells protect injured CNS neurons via IL-4.
Walsh, J.T., Hendrix, S., Boato, F., Smirnov, I., Zheng, J., Lukens, J.R., Gadani, S., Hechler, D., Gölz, G., Rosenberger, K., Kammertöns, T., Vogt, J., Vogelaar, C., Siffrin, V., Radjavi, A., Fernandez-Castaneda, A., Gaultier, A., Gold, R., Kanneganti, T.D., Nitsch, R., Zipp, F. and Kipnis, J.
Journal of Clinical Investigation 125
(2): 699-714.
2 February 2015
2014
Efficacy of CAR T-cell therapy in large tumors relies upon stromal targeting by IFNγ.
Textor, A., Listopad, J.J., Wührmann, L.L., Perez, C., Kruschinski, A., Chmielewski, M., Abken, H., Blankenstein, T. and Charo, J.
Cancer Research 74
(23): 6796-6805.
1 December 2014
Misinitiation of intrathymic MART-1 transcription and biased TCR usage explain the high frequency of MART-1-specific T cells.
Pinto, S., Sommermeyer, D., Michel, C., Wilde, S., Schendel, D., Uckert, W., Blankenstein, T. and Kyewski, B.
European Journal of Immunology 44
(9): 2811-2821.
September 2014
Permissive expansion and homing of adoptively transferred T cells in tumor-bearing hosts.
Perez, C., Jukica, A., Listopad, J.J., Anders, K., Kühl, A.A., Loddenkemper, C., Blankenstein, T. and Charo, J.
International Journal of Cancer 137
(2): 359-371.
15 July 2014
2013
IL-13 but not IL-4 signaling via IL-4Rα protects mice from papilloma formation during DMBA/TPA two-step skin carcinogenesis.
Rothe, M., Quarcoo, D., Chashchina, A.A., Bozrova, S.V., Qin, Z., Nedospasov, S.A., Blankenstein, T., Kammertoens, T. and Drutskaya, M.S.
Cancer Medicine 2
(6): 815-825.
December 2013
High-throughput identification of antigen-specific TCRs by TCR gene capture.
Linnemann, C., Heemskerk, B., Kvistborg, P., Kluin, R.J.C., Bolotin, D.A., Chen, X., Bresser, K., Nieuwland, M., Schotte, R., Michels, S., Gomez-Eerland, R., Jahn, L., Hombrink, P., Legrand, N., Shu, C.J., Mamedov, I.Z., Velds, A., Blank, C.U., Haanen, J.B.A.G., Turchaninova, M.A., Kerkhoven, R.M., Spits, H., Hadrup, S.R., Heemskerk, M.H.M., Blankenstein, T., Chudakov, D.M., Bendle, G.M. and Schumacher, T.N.M.
Nature Medicine 19
(11): 1534-1541.
November 2013
Vaccine-instructed intratumoral IFN-γ enables regression of autochthonous mouse prostate cancer in allogeneic T cell transplantation.
Hess Michelini, R., Manzo, T., Sturmheit, T., Basso, V., Rocchi, M., Freschi, M., Listopad, J.J., Blankenstein, T., Bellone, M. and Mondino, A.
Cancer Research 73
(15): 4641-4652.
1 August 2013
Adoptive T-cell therapy to treat liver cancer: Is the liver microenvironment key?
Willimsky, G., Protzer, U., Knolle, P. and Heikenwalder, M.
Oncotarget 4
(8): 1117-1118.
August 2013
Generation of transgenic mice with megabase-sized human yeast artificial chromosomes by yeast spheroplast-embryonic stem cell fusion.
Li, L. and Blankenstein, T.
Nature Protocols 8
(8): 1567-1582.
August 2013
Fibroblast-specific protein 1/S100A4-positive cells prevent carcinoma through collagen production and encapsulation of carcinogens.
Zhang, J, Chen, L, Liu, X, Kammertoens, T., Blankenstein, T. and Qin, Z.
Cancer Research 73
(9): 2770-2781.
1 May 2013
It's the peptide-MHC affinity, stupid.
Kammertoens, T. and Blankenstein, T.
Cancer Cell 23
(4): 429-431.
15 April 2013
Differently immunogenic cancers in mice induce immature myeloid cells that suppress CTL in vitro but not in vivo following transfer.
Schmidt, K., Zilio, S., Schmollinger, J.C., Bronte, V., Blankenstein, T. and Willimsky, G.
Blood 121
(10): 1740-1748.
7 March 2013
Virus-induced hepatocellular carcinomas cause antigen-specific local tolerance.
Willimsky, G., Schmidt, K., Loddenkemper, C., Gellermann, J. and Blankenstein, T.
Journal of Clinical Investigation 123
(3): 1032-1043.
1 March 2013
High immune response rates and decreased frequencies of regulatory T cells in metastatic renal cell carcinoma patients after tumor cell vaccination.
Pohla, H., Buchner, A., Stadlbauer, B., Frankenberger, B., Stevanovic, S., Walter, S., Frank, R., Schwachula, T., Olek, S., Kopp, J., Willimsky, G., Stief, C.G., Hofstetter, A., Pezzutto, A., Blankenstein, T., Oberneder, R. and Schendel, D.J.
Molecular Medicine 18
: 1499-1508.
8 February 2013
Fas expression by tumor stroma is required for cancer eradication.
Listopad, J.J., Kammertoens, T., Anders, K., Silkenstedt, B., Willimsky, G., Schmidt, K., Kuehl, A.A., Loddenkemper, C. and Blankenstein, T.
Proceedings of the National Academy of Sciences of the United States of America 110
(6): 2276-2281.
5 February 2013
Molecular pathways: comparing the effects of drugs and T cells to effectively target oncogenes.
Anders, K. and Blankenstein, T.
Clinical Cancer Research 19
(2): 320-326.
15 January 2013
2012
Differences in serum cytokine levels between wild type mice and mice with a targeted mutation suggests necessity of using control littermates.
Briesemeister, D., Friese, C., Isern, C.C., Dietz, E., Blankenstein, T., Thoene-Reineke, C. and Kammertoens, T.
Cytokine 60
(3): 626-633.
December 2012
Spontaneous and therapy-induced T cell responses to cancer.
Blankenstein, T.
Arzneimittelforschung 62
(1): S9.
November 2012
B-cells and IL-4 promote methylcholanthrene-induced carcinogenesis but there is no evidence for a role of T/NKT-cells and their effector molecules (Fas-ligand, TNF-α, perforin).
Kammertoens, T., Qin, Z., Briesemeister, D., Bendelac, A. and Blankenstein, T.
International Journal of Cancer 131
(7): 1499-1508.
1 October 2012
Depot formation of doxycycline impairs Tet-regulated gene expression in vivo.
Anders, K., Buschow, C., Charo, J. and Blankenstein, T.
Transgenic Research 21
(5): 1099-1107.
October 2012
A novel MCPH1 isoform complements the defective chromosome condensation of human MCPH1-deficient cells.
Gavvovidis, I., Rost, I., Trimborn, M., Kaiser, F.J., Purps, J., Wiek, C., Hanenberg, H., Neitzel, H. and Schindler, D.
PLoS ONE 7
(8): e40387.
30 August 2012
The determinants of tumour immunogenicity.
Blankenstein, T., Coulie, P.G., Gilboa, E. and Jaffee, E.M.
Nature Reviews Cancer 12
(4): 307-313.
April 2012
Stromal interferon-γ signaling and cross-presentation are required to eliminate antigen-loss variants of B cell lymphomas in mice.
Gerbitz, A., Sukumar, M., Helm, F., Wilke, A., Friese, C., Fahrenwaldt, C., Lehmann, F.M., Loddenkemper, C., Kammertoens, T., Mautner, J., Schmitt, C.A., Blankenstein, T. and Bornkamm, G.W.
PLoS ONE 7
(3): e34552.
30 March 2012
2011
Oncogene-targeting T cells reject large tumors while oncogene inactivation selects escape variants in mouse models of cancer.
Anders, K., Buschow, C., Herrmann, A., Milojkovic, A., Loddenkemper, C., Kammertoens, T., Daniel, P., Yu, H., Charo, J. and Blankenstein, T.
Cancer Cell 20
(6): 755-767.
13 December 2011
Visualizing the dynamic of adoptively transferred T cells during the rejection of large established tumors.
Charo, J., Perez, C., Buschow, C., Jukica, A., Czeh, M. and Blankenstein, T.
European Journal of Immunology 41
(11): 3187-3197.
November 2011
The only proposed T-cell epitope derived from the TEL-AML1 translocation is not naturally processed.
Popovic, J., Li, L.P., Kloetzel, P.M., Leisegang, M., Uckert, W. and Blankenstein, T.
Blood 118
(4): 946-954.
28 July 2011
Allogeneic gene-modified tumor cells (RCC-26/IL-7/CD80) as a vaccine in patients with metastatic renal cell cancer: a clinical phase-I study.
Westermann, J., Floercken, A., Willimsky, G., van Lessen, A., Kopp, J., Takvorian, A., Joehrens, K., Lukowsky, A., Schoenemann, C., Sawitzki, B., Pohla, H., Frank, R., Doerken, B., Schendel, D.J., Blankenstein, T. and Pezzutto, A.
Gene Therapy 18
(4): 354-363.
April 2011
Tumor rejection by local interferon gamma induction in established tumors is associated with blood vessel destruction and necrosis.
Briesemeister, D., Sommermeyer, D., Loddenkemper, C., Loew, R., Uckert, W., Blankenstein, T. and Kammertoens, T.
International Journal of Cancer 128
(2): 371-378.
15 January 2011
2010
The immune response to sporadic colorectal cancer in a novel mouse model.
Czeh, M., Loddenkemper, C., Shalapour, S., Schoen, C., Robine, S., Goldscheid, E., Stein, H., Schueler, T., Willimsky, G. and Blankenstein, T.
Oncogene 29
(50): 6591-6602.
16 December 2010
Heat shock factor 1 ameliorates proteotoxicity in cooperation with the transcription factor NFAT.
Hayashida, N., Fujimoto, M., Tan, K., Prakasam, R., Shinkawa, T., Li, L., Ichikawa, H., Takii, R. and Nakai, A.
EMBO Journal 29
(20): 3459-3469.
20 October 2010
Commensal microflora and interferon-gamma promote steady-state interleukin-7 production in vivo.
Shalapour, S., Deiser, K., Sercan, O., Tuckermann, J., Minnich, K., Willimsky, G., Blankenstein, T., Haemmerling, G.J., Arnold, B. and Schueler, T.
European Journal of Immunology 40
(9): 2391-2400.
September 2010
Transgenic mice with a diverse human T cell antigen receptor repertoire.
Li, L.P., Lampert, J.C., Chen, X., Leitao, C., Popovic, J., Mueller, W. and Blankenstein, T.
Nature Medicine 16
(9): 1029-1034.
September 2010
Vaccination with a plasmid DNA encoding HER-2/neu together with low doses of GM-CSF and IL-2 in patients with metastatic breast carcinoma: a pilot clinical trial.
Norell, H., Poschke, I., Charo, J., Wei, W.Z., Erskine, C., Piechocki, M.P., Knutson, K.L., Bergh, J., Lidbrink, E. and Kiessling, R.
Journal of Translational Medicine 8
(1): 53.
7 June 2010
T-cell receptor gene-modified T cells with shared renal cell carcinoma specificity for adoptive T-cell therapy.
Leisegang, M., Turqueti-Neves, A., Engels, B., Blankenstein, T., Schendel, D.J., Uckert, W. and Noessner, E.
Clinical Cancer Research 16
(8): 2333-2343.
15 April 2010
In vivo imaging of an inducible oncogenic tumor antigen visualizes tumor progression and predicts CTL tolerance.
Buschow, C., Charo, J., Anders, K., Loddenkemper, C., Jukica, A., Alsamah, W., Perez, C., Willimsky, G. and Blankenstein, T.
Journal of Immunology 184
(6): 2930-2938.
15 March 2010
Leukemia-associated genetic aberrations in mesenchymal stem cells of children with acute lymphoblastic leukemia.
Shalapour, S., Eckert, C., Seeger, K., Pfau, M., Prada, J., Henze, G., Blankenstein, T. and Kammertoens, T.
Journal of Molecular Medicine 88
(3): 249-265.
March 2010
Phase I trial of an allogeneic gene-modified tumor cell vaccine (RCC-26/CD80/IL-2) in patients with metastatic renal cell carcinoma.
Buchner, A., Pohla, H., Willimsky, G., Frankenberger, B., Frank, R., Baur-Melnyk, A., Siebels, M., Stief, C.G., Hofstetter, A., Kopp, J., Pezzutto, A., Blankenstein, T., Oberneder, R. and Schendel, D.J.
Human Gene Therapy 21
(3): 285-297.
March 2010
2009
Adaptive peripheral immune response increases proliferation of neural precursor cells in the adult hippocampus.
Wolf, S.A., Steiner, B., Wengner, A.M., Lipp, M., Kammertoens, T. and Kempermann, G.
FASEB Journal 23
(9): 3121-3128.
September 2009
Making and circumventing tolerance to cancer.
Kammertoens, T. and Blankenstein, T.
European Journal of Immunology 39
(9): 2345-2353.
September 2009
HER-2/neu mediated down-regulation of MHC class I antigen processing prevents CTL-mediated tumor recognition upon DNA vaccination in HLA-A2 transgenic mice.
Vertuani, S., Triulzi, C., Roos, A.K., Charo, J., Norell, H., Lemonnier, F., Pisa, P., Seliger, B. and Kiessling, R.
Cancer Immunology Immunotherapy 58
(5): 653-664.
May 2009
CD4-positive T lymphocytes provide a neuroimmunological link in the control of adult hippocampal neurogenesis.
Wolf, S.A., Steiner, B., Akpinarli, A., Kammertoens, T., Nassenstein, C., Braun, A., Blankenstein, T. and Kempermann, G.
Journal of Immunology 182
(7): 3979-3984.
1 April 2009
Positioning of subdomain IIId and apical loop of domain II of the hepatitis C IRES on the human 40S ribosome.
Babaylova, E., Graifer, D., Malygin, A., Stahl, J., Shatsky, I. and Karpova, G.
Nucleic Acids Research 37
(4): 1141-1151.
March 2009
2008
Engineering antigen-specific primary human NK cells against HER-2 positive carcinomas.
Kruschinski, A., Moosmann, A., Poschke, I., Norell, H., Chmielewski, M., Seliger, B., Kiessling, R., Blankenstein, T., Abken, H. and Charo, J.
Proceedings of the National Academy of Sciences of the United States of America 105
(45): 17481-17486.
11 November 2008
Protein S3 fragments neighboring mRNA during elongation and termination of translation on the human ribosome.
Khairulina, Y.S., Molotkov, M.V., Bulygin, K.N., Graifer, D.M., Ven’yaminova, A.G., Frolova, L.Y., Stahl, J. and Karpova, G.G.
Russian Journal of Bioorganic Chemistry 34
(6): 691-697.
November 2008
SV40 large T antigen-transformed human primary normal and cancerous mammary epithelial cells are phenotypically similar but can be distinguished in 3D culture with selection medium.
Li, L.P., Willimsky, G., Seitz, S., Xu, Y., Li, Y., Schwarz, L.E., Schlag, P.M. and Blankenstein, T.
International Journal of Cancer 123
(7): 1516-1525.
1 October 2008
Ablation of TNF or lymphotoxin signaling and the frequency of spontaneous tumors in p53-deficient mice.
Kuprash, D.V., Qin, Z., Ito, D., Grivennikov, S.I., Abe, K., Drutskaya, L.N., Blankenstein, T. and Nedospasov, S.A.
Cancer Letters 268
(1): 70-75.
8 September 2008
Immunogenicity of premalignant lesions is the primary cause of general cytotoxic T lymphocyte unresponsiveness.
Willimsky, G., Czeh, M., Loddenkemper, C., Gellermann, J., Schmidt, K., Wust, P., Stein, H. and Blankenstein, T.
Journal of Experimental Medicine 205
(7): 1687-1700.
7 July 2008
A safeguard eliminates T cell receptor gene-modified autoreactive T cells after adoptive transfer.
Kieback, E., Charo, J., Sommermeyer, D., Blankenstein, T. and Uckert, W.
Proceedings of the National Academy of Sciences of the United States of America 105
(2): 623-628.
15 January 2008
2007
The adaptive immune response to sporadic cancer.
Willimsky, G. and Blankenstein, T.
Immunological Reviews 220
(1): 102-112.
December 2007
Neuroimmune crosstalk in asthma: dual role of the neurotrophin receptor p75NTR.
Nassenstein, C., Kammertoens, T., Veres, T.Z., Uckert, W., Spies, E., Fuchs, B., Krug, N. and Braun, A.
Journal of Allergy and Clinical Immunology 120
(5): 1089-1096.
November 2007
Dual T cell receptor expressing CD8+ T cells with tumor- and self-specificity can inhibit tumor growth without causing severe autoimmunity.
Weinhold, M., Sommermeyer, D., Uckert, W. and Blankenstein, T.
Journal of Immunology 179
(8): 5534-5542.
15 October 2007
In vivo splenic CD11c cells downregulate CD4 T-cell response thereby decreasing systemic immunity to gene-modified tumour cell vaccine.
Cayeux, S., Bukarica, B., Buschow, C., Charo, J., Bunse, M., Doerken, B. and Blankenstein, T.
Gene Therapy 14
(20): 1481-1491.
October 2007
Do autochthonous tumors interfere with effector T cell responses?
Blankenstein, T.
Seminars in Cancer Biology 17
(4): 267-274.
August 2007
IL-10 controls ultraviolet-induced carcinogenesis in mice.
Loser, K., Apelt, J., Voskort, M., Mohaupt, M., Balkow, S., Schwarz, T., Grabbe, S. and Beissert, S.
Journal of Immunology 179
(1): 365-371.
1 July 2007
Tumor necrosis factor receptor 2-mediated tumor suppression is nitric oxide dependent and involves angiostasis.
Zhao, X., Mohaupt, M., Jiang, J., Liu, S., Li, B. and Qin, Z.
Cancer Research 67
(9): 4443-4450.
1 May 2007
Active MAC-1 (CD11b/CD18) on DC is inhibitory for full T cell activation.
Varga, G., Balkow, S., Wild, M.K., Stadtbaeumer, A., Krummen, M., Rothoeft, T., Higuchi, T., Beissert, S., Wethmar, K., Scharffetter-Kochanek, K., Vestweber, D. and Grabbe, S.
Blood 109
(2): 661-669.
15 January 2007
Construction of a T cell line-based packaging cell line for the production of T cell receptor retroviruses by enriching of Cd3 expressing cells.
Uckert, W. and Blankenstein, T.
WO0700318.
4 January 2007
T cell homing to tumors detected by 3D-coordinated positron emission tomography and magnetic resonance imaging.
Agger, R., Petersen, M.S., Petersen, C.C., Hansen, S.B., Stodkilde-Jorgensen, H., Skands, U., Blankenstein, T., Andersen, T.E., Hulgaard, E.F., Jorgensen, J.T., Marqversen, J., Gundersen, H.J. and Hokland, M.E.
Journal of Immunotherapy 30
(1): 29-39.
January 2007
2006
Designer T cells by T cell receptor replacement.
Sommermeyer, D., Neudorfer, J., Weinhold, M., Leisegang, M., Engels, B., Noessner, E., Heemskerk, M.H., Charo, J., Schendel, D.J., Blankenstein, T., Bernhard, H. and Uckert, W.
European Journal of Immunology 36
(11): 3052-3059.
November 2006
Migration of immature mouse DC across resting endothelium is mediated by ICAM-2 but independent of beta2-integrins and murine DC-SIGN homologues.
Wethmar, K., Helmus, Y., Luehn, K., Jones, C., Laskowska, A., Varga, G., Grabbe, S., Lyck, R., Engelhardt, B., Bixel, M.G., Butz, S., Loser, K., Beissert, S., Ipe, U., Vestweber, D. and Wild, M.K.
European Journal of Immunology 36
(10): 2781-2794.
October 2006
2005
Sporadic immunogenic tumours avoid destruction by inducing T-cell tolerance.
Willimsky, G. and Blankenstein, T.
Nature 437
(7055): 141-146.
1 September 2005
Cell-based vaccines for renal cell carcinoma: genetically-engineered tumor cells and monocyte-derived dendritic cells.
Frankenberger, B., Regn, S., Geiger, C., Noessner, E., Falk, C.S., Pohla, H., Javorovic, M., Silberzahn, T., Wilde, S., Buchner, A., Siebels, M., Oberneder, R., Willimsky, G., Pezzutto, A., Blankenstein, T. and Schendel, D.J.
World Journal of Urology 23
(3): 166-174.
5 July 2005
Redirecting human T lymphocytes toward renal cell carcinoma specificity by retroviral transfer of T cell receptor genes.
Engels, B., Noessner, E., Frankenberger, B., Blankenstein, T., Schendel, D.J. and Uckert, W.
Human Gene Therapy 16
(7): 799-810.
1 July 2005
Gentherapie mit T-Zellrezeptor modifizierten Zellen.
Uckert, W. and Blankenstein, T.
BioForum 28
(3): 27-30.
20 May 2005
CY15, a malignant histiocytic tumor that is phenotypically similar to immature dendritic cells.
Kammertoens, T., Willebrand, R., Erdmann, B., Li, L., Li, Y., Engels, B., Uckert, W. and Blankenstein, T.
Cancer Research 65
: 2560-2564.
1 January 2005
Immunotherapy: target the stroma to hit the tumor.
Kammertoens, T., Schueler, T. and Blankenstein, T.
Trends in Molecular Medicine 11
(5): 225-231.
1 January 2005
Induction of PSA-specific CTLs and anti-tumor immunity by a genetic prostate cancer vaccine.
Roos, A.K., Pavlenko, M., Charo, J., Egevad, L. and Pisa, P.
Prostate 62
(3): 217-223.
1 January 2005
Influence of CD80, interleukin-2, and interleukin-7 expression in human renal cell carcinoma on the expansion, function, and survival of tumor-specific CTLs.
Frankenberger, B., Pohla, H., Noessner, E., Willimsky, G., Papier, B., Pezzutto, A., Kopp, J., Oberneder, R., Blankenstein, T. and Schendel, D.J.
Clinical Cancer Research 11
: 1733-1742.
1 January 2005
Necrotic death but not irradiation abolishes costimulation of T-cell effector functions and survival by CD80-expressing tumor cells.
Staerck, L., Scholz, C., Blankenstein, T., Doerken, B. and Daniel, P.T.
International Journal of Cancer 116
(1): 78-86.
1 January 2005
The role of tumor stroma in the interaction between tumor and immune system.
Blankenstein, T.
Current Opinion in Immunology 17
(2): 180-186.
1 January 2005
Tumor-induced antibodies resemble the response to tissue damage.
Preiss, S., Kammertoens, T., Lampert, C., Willimsky, G. and Blankenstein, T.
International Journal of Cancer 115
(3): 456-462.
1 January 2005
2004
CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions.
Ohl, L., Mohaupt, M., Czeloth, N., Hintzen, G., Kiafard, Z., Zwirner, J., Blankenstein, T., Henning, G. and Foerster, R.
Immunity 21
(2): 279-288.
1 August 2004
Dual T cell receptor T cells with two defined specificities mediate tumor suppression via both receptors.
Gladow, M., Uckert, W. and Blankenstein, T.
European Journal of Immunology 34
(7): 1882-1891.
1 July 2004
The role of inflammation for tumour growth and tumour suppression.
Blankenstein, T.
In:
Cancer and inflammation : Symposium on Cancer and Inflammation, held at the Novartis Foundation, London, 12-14 November 2002.
Novartis Foundation Symposium ; 256
.
Wiley, Hoboken, N.J., 205-210.
ISBN 0-470-85510-X
23 January 2004
A cancer immunosurveillance controversy.
Qin, Z.H. and Blankenstein, T.
Nature Immunology 5
(1): 3-4.
1 January 2004
A synthetic peptide homologous to functional domain of human IL-10 down-regulates expression of MHC class I and transporter associated with antigen processing 1/2 in human melanoma cells.
Kurte, M., Lopez, M., Aguirre, A., Escobar, A., Aguillon, J.C., Charo, J., Larsen, C.G., Kiessling, R. and Salazar-Onfray, F.
Journal of Immunology 173
(3): 1731-1737.
1 January 2004
CD4+ T cell-mediated HER-2/neu-specific tumor rejection in the absence of B cells.
Lindencrona, J.A., Preiss, S., Kammertoens, T., Schueler, T., Piechocki, M., Wei, W.Z., Seliger, B., Blankenstein, T. and Kiessling, R.
International Journal of Cancer 109
(2): 259-264.
1 January 2004
Establishment of early lymphoid organ infrastructure in transplanted tumors mediated by local production of lymphotoxin alpha and in the combined absence of functional B and T cells.
Kim, H.J., Kammertoens, T., Janke, M., Schmetzer, O., Qin, Z., Berek, C. and Blankenstein, T.
Journal of Immunology 172
(7): 4037-4047.
1 January 2004
Flt-3 ligand as adjuvant for DNA vaccination augments immune responses but does not skew TH1/TH2 polarization.
Westermann, J., Nguyen-Hoai, T., Mollweide, A., Richter, G., Schmetzer, O., Kim, H.J., Blankenstein, T., Doerken, B. and Pezzutto, A.
Gene Therapy 11
(13): 1048-1056.
1 January 2004
Graft-versus-host disease after allogeneic hematopoietic stem cell transplantation induces a CD8+ T cell-mediated graft-versus-tumor effect that is independent of the recognition of alloantigenic tumor targets.
Stelljes, M., Strothotte, R., Pauels, H.G., Poremba, C., Milse, M., Specht, C., Albring, J., Bisping, G., Scheffold, C., Kammertoens, T., Oelmann, E., Silling, G., Berdel, W.E. and Kienast, J.
Blood 104
(4): 1210-1216.
1 January 2004
Long-term suppression of tumor growth by TNF requires a Stat1- and IFN regulatory factor 1-dependent IFN-γ pathway but not IL-12 or IL-18.
Wu, T.H., Pabin, C.N., Qin, Z.H., Blankenstein, T., Philip, M., Dignam, J., Schreiber, K. and Schreiber, H.
Journal of Immunology 172
(5): 3243-3251.
1 January 2004
2003
Transduction efficiency of MLV but not of HIV-1 vectors is pseudotype dependent on human primary T lymphocytes.
Muehlebach, M.D., Schmitt, I., Steidl, S., Stitz, J., Schweizer, M., Blankenstein, T., Cichutek, K. and Uckert, W.
Journal of Molecular Medicine 81
(12): 801-810.
December 2003
Tumor rejection by modulation of tumor stromal fibroblasts.
Schueler, T., Koernig, S. and Blankenstein, T.
Journal of Experimental Medicine 198
(10): 1487-1493.
17 November 2003
Retroviral vectors for high-level transgene expression in T lymphocytes.
Engels, B., Cam, H., Schueler, T., Indraccolo, S., Gladow, M., Baum, C., Blankenstein, T. and Uckert, W.
Human Gene Therapy 14
(12): 1155-1168.
10 August 2003
Cutting edge: CD8+ effector T cells reject tumors by direct antigen recognition but indirect action on host cells.
Schueler, T. and Blankenstein, T.
Journal of Immunology 170
(9): 4427-4431.
1 May 2003
The role of IFN-gamma in tumor transplantation immunity and inhibition of chemical carcinogenesis.
Blankenstein, T. and Qin, Z.H.
Current Opinion in Immunology 15
(2): 148-154.
April 2003
Nicotine strongly activates dendritic cell-mediated adaptive immunity - Potential role for progression of atherosclerotic lesions.
Aicher, A., Heeschen, C., Mohaupt, M., Cooke, J.P., Zeiher, A.M. and Dimmeler, S.
Circulation 107
(4): 604-611.
4 February 2003
Overexpression of NPM-ALK induces different types of malignant lymphomas in IL-9 transgenic mice.
Lange, K., Uckert, W., Blankenstein, T., Nadrowitz, R., Bittner, C., Renauld, J.C., van Snick, J., Feller, A.C. and Merz, H.
Oncogene 22
(4): 517-527.
30 January 2003
A critical requirement of interferon gamma-mediated angiostasis for tumor rejection by CD8T cells.
Qin, Z.H., Schwartzkopff, J., Pradera, F., Kammertoens, T., Seliger, B., Pircher, H. and Blankenstein, T.
Cancer Research 63
(14): 4095-4100.
1 January 2003
Die Ueberexpression von NPM-ALK in haematopoietischen Stammzellen induziert verschiedene maligne Non-Hodgkin-Lymphome in der IL-9 transgenen Maus [Overexpression of NPM-ALK induces different types of malignant lymphomas in IL-9 transgenic mice].
Merz, H., Lange, K., Nadrowitz, R., Uckert, W., Blankenstein, T. and Feller, A.C.
Verhandlungen der Deutschen Gesellschaft fuer Pathologie 87
: 224-231.
1 January 2003
Chemical carcinogens as foreign bodies and some pitfalls regarding cancer immune surveillance.
Blankenstein, T. and Qin, Z.
Advances in Cancer Research 90
: 179-207.
2003
2002
Adenoviral transduction of tumor cells induces apoptosis in co-cultured T lymphocytes.
Scholz, C., Staerck, L., Willimsky, G., Blankenstein, T., Doerken, B. and Daniel, P.T.
Gene Therapy 9
(21): 1438-1446.
November 2002
Naive CD8+ but not CD4+ T cells induce maturation of dendritic cells.
Schueler, T. and Blankenstein, T.
Journal of Molecular Medicine 80
(8): 533-541.
August 2002
Inhibition of methylcholanthrene-induced carcinogenesis by an interferon gamma receptor-dependent foreign body reaction.
Qin, Z., Kim, H.J., Hemme, J. and Blankenstein, T.
Journal of Experimental Medicine 195
(11): 1479-1490.
3 June 2002
Increased tumorigenicity, but unchanged immunogenicity, of transporter for antigen presentation 1-deficient tumors.
Qin, Z., Harders, C., Cao, X., Huber, C., Blankenstein, T. and Seliger, B.
Cancer Research 62
(10): 2856-2860.
15 May 2002
Cross-priming versus cross-tolerance: are two signals enough?
Blankenstein, T. and Schueler, T.
Trends in Immunology 23
(4): 171-173.
1 April 2002
2001
Generation of tumor-associated cytotoxic T lymphocytes requires interleukin 4 from CD8+ T cells.
Schueler, T., Kammertoens, T., Preiss, S., Debs, P., Noben-Trauth, N. and Blankenstein, T.
Journal of Experimental Medicine 194
(12): 1767-1775.
17 December 2001
Tumor rejection by disturbing tumor stroma cell interactions.
Ibe, S., Qin, Z.H., Schueler, T., Preiss, S. and Blankenstein, T.
Journal of Experimental Medicine 194
(11): 1549-1559.
3 December 2001
The role of toll-like receptors (TLRs) in bacteria-induced maturation of murine dendritic cells (DCS). Peptidoglycan and lipoteichoic acid are inducers of DC maturation and require TLR2.
Michelsen, K.S., Aicher, A., Mohaupt, M., Hartung, T., Dimmeler, S., Kirschning, C.J. and Schumann, R.R.
Journal of Biological Chemistry 276
(28): 25680-25686.
13 July 2001
Adoptive tumor therapy with T lymphocytes enriched through an IFN-gamma capture assay.
Becker, C., Pohla, H., Frankenberger, B., Schueler, T., Assenmacher, M., Schendel, D.J. and Blankenstein, T.
Nature Medicine 7
(10): 1159-1162.
1 January 2001
Characterization of the major histocompatibility complex class I deficiencies in B16 melanoma cells.
Seliger, B., Wollscheid, U., Momburg, F., Blankenstein, T. and Huber, C.
Cancer Research 61
: 1095-1099.
1 January 2001
Decreased generation of anti-tumor immunity after intrasplenic immunization.
Cayeux, S., Qin, Z.H., Doerken, B. and Blankenstein, T.
European Journal of Immunology 31
(5): 1392-1399.
1 January 2001
Osteoprotegerin, a crucial regulator of bone metabolism, also regulates B cell development and function.
Yun, T.J., Tallquist, M.D., Aicher, A., Rafferty, K.L., Marshall, A.J., Moon, J.J., Ewings, M.K., Mohaupt, M., Herring, S.W. and Clark, E.A.
Journal of Immunology 166
: 1482-1491.
1 January 2001
Suicide gene therapy for pediatric tumors.
Beltinger, C., Uckert, W. and Debatin, K.M.
Journal of Molecular Medicine 78
(11): 598-612.
1 January 2001
2000
Expression of B7.1 (CD80) in a renal cell carcinoma line allows expansion of tumor-associated cytotoxic T lymphocytes in the presence of an alloresponse.
Schendel, D.J., Frankenberger, B., Jantzer, P., Cayeux, S., Noessner, E., Willimsky, G., Maget, B., Pohla, H. and Blankenstein, T.
Gene Therapy 7
(23): 2007-2014.
1 December 2000
Coordinate downregulation of multiple MHC class I antigen processing genes in chemical-induced murine tumor cell lines of distinct origin.
Seliger, B., Wollscheid, U., Momburg, F., Blankenstein, T. and Huber, C.
Tissue Antigens 56
(4): 327-336.
1 October 2000
CD4+ T cell-mediated tumor rejection involves inhibition of angiogenesis that is dependent on IFNgamma receptor expression by nonhematopoietic cells.
Qin, Z.H. and Blankenstein, T.
Immunity 12
(6): 677-686.
1 June 2000
Allogeneic vaccination for renal cell carcinoma: development and monitoring.
Pohla, H., Frankenberger, B., Stadlbauer, B., Oberneder, R., Hofstetter, A., Willimsky, G., Pezzutto, A., Doerken, B., Blankenstein, T. and Schendel, D.J.
Bone Marrow Transplantation 25 Suppl. 2
(3332): S83-S87.
1 May 2000
Bcr/abl+ autologous dendritic cells for vaccination in chronic myeloid leukemia.
Westermann, J., Kopp, J., Koerner, I., Richter, G., Qin, Z., Blankenstein, T., Doerken, B. and Pezzutto, A.
Bone Marrow Transplantation 25 Suppl. 2
(3332): S46-S49.
1 May 2000
Combined chemotherapy of murine mammary tumors by local activation of the prodrugs ifosfamide and 5-fluorocytosine.
Kammertoens, T., Gelbmann, W., Karle, P., Alton, K., Saller, R., Salmons, B., Guenzburg, W.H. and Uckert, W.
Cancer Gene Therapy 7
(4): 629-636.
1 April 2000
Interleukin-7/B7.1-encoding adenoviruses induce rejection of transplanted but not nontransplanted tumors.
Willimsky, G. and Blankenstein, T.
Cancer Research 60
(3): 685-692.
1 February 2000
Efficient gene transfer into primary human CD8+ T lymphocytes by MuLV-10A1 retrovirus pseudotype.
Uckert, W., Becker, C., Gladow, M., Klein, D., Kammertoens, T., Pedersen, L. and Blankenstein, T.
Human Gene Therapy 11
(7): 1005-1014.
1 January 2000
Green fluorescent protein retroviral vector. Generation of high-titer producer cells and virus supernatant.
Uckert, W., Pedersen, L. and Guenzburg, W.
In:
Gene Therapy of Cancer : Methods and Protocols.
Methods in Molecular Medicine. ; 35
.
Humana Press, Totowa,NJ, 275-285.
1 January 2000
Lentiviral vectors pseudotyped with envelope glycoproteins derived from gibbon ape leukemia virus and murine leukemia virus 10A1.
Stitz, J., Buchholz, C.J., Engelstaedter, M., Uckert, W., Bloemer, U., Schmitt, I. and Cichutek, K.
Virology 273
(1): 16-20.
1 January 2000
MLV-10A1 retrovirus pseudotype efficiently transduces primary human CD4+ T lymphocytes.
Gladow, M., Becker, C., Blankenstein, T. and Uckert, W.
Journal of Gene Medicine 2
(6): 409-415.
1 January 2000
Mitochondrial amplification of death signals determines thymidine kinase/ ganciclovir-triggered activation of apoptosis.
Beltinger, C., Fulda, S., Kammertoens, T., Uckert, W. and Debatin, K.M.
Cancer Research 60
(12): 3212-3217.
1 January 2000
Modulation of moloney leukemia virus long terminal repeat transcriptionalactivity by the murine CD4 silencer in retroviral vectors.
Indraccolo, S., Minuzzo, S., Habeler, W., Zamarchi, R., Fregonese, A., Guenzburg, W.H., Salmons, B., Uckert, W., Chieco-Bianchi, L. and Amadori, A.
Virology 276
: 83-92.
1 January 2000
1999
Herpes simplex virus thymidine kinase/ganciclovir-induced apoptosis involves ligand-independent death receptor aggregation and activation of caspases.
Beltinger, C., Fulda, S., Kammertoens, T., Meyer, E., Uckert, W. and Debatin, K.M.
Proceedings of the National Academy of Sciences of the United States of America 96
: 8699-8704.
20 July 1999
T helper cell type 1-associated and cytotoxic T lymphocyte-mediated tumor immunity is impaired in interleukin 4-deficient mice.
Schueler, T., Qin, Z., Ibe, S., Noben-Trauth, N. and Blankenstein, T.
Journal of Experimental Medicine 189
(5): 803-810.
1 March 1999
Konditionales Immortalisationsverfahren fuer humane Tumorzellen zur Herstellung einer Vakzine.
Blankenstein, T. and Li, L.P.
DE19626830A1.
8 January 1999
Direct and indirect T cell priming by dendritic cell vaccines.
Cayeux, S., Richter, G., Becker, C., Pezzutto, A., Doerken, B. and Blankenstein, T.
European Journal of Immunology 29
: 225-234.
1 January 1999
Gene Therapy of Familial Hypercholesterolemia.
Cichon, G. and Strauss, M.
In:
Gene therapy :Principles and Applications.
Birkhaeuser, Basel, 151-167.
ISBN 3-7643-5972-2
1 January 1999
Gene therapy :Principles and Applications.
Blankenstein, T.
Birkhaeuser, Basel.
ISBN 3-7643-5972-2
1 January 1999
Vaccines using gene-modified tumor cells.
Cayeux, S., Qin, Z., Doerken, B. and Blankenstein, T.
In:
Gene therapy :Principles and Applications.
Birkhaeuser, Basel, 283-298.
ISBN 3-7643-5972-2
1 January 1999
1998
Mittel zur Behandlung von Tumorerkrankungen durch Entfernen von B-Lymphozyten der Patienten.
Blankenstein, T. and Qin, Z.
DE19720154A1.
5 November 1998
Constitutive IL-10 production accounts for the high NK sensitivity, low MHC class I expression, and poor transporter associated with antigen processing (TAP)-1/2 function in the prototype NK target YAC-11.
Petersson, M., Charo, J., Salazar-Onfray, F., Noffz, G., Mohaupt, M., Qin, Z.H., Klein, G., Blankenstein, T. and Kiessling, R.
Journal of Immunology 161
: 2099-2105.
1 September 1998
Interleukin 4 gene-defective mice reconstituted with wild-type bone marrow fail to produce normal immunoglobulin E levels.
Lange, C., Schueler, T. and Blankenstein, T.
Journal of Experimental Medicine 187
(9): 1487-1493.
4 May 1998
B cells inhibit induction of T cell-dependent tumor immunity.
Qin, Z.H., Richter, G., Schueler, T., Ibe, S., Cao, X.T. and Blankenstein, T.
Nature Medicine 4
: 627-630.
1 January 1998
Double suicide gene (cytosine deaminase and herpes simplex virus thymidine kinase) but not single gene transfer allows reliable elimination of tumor cells in vivo.
Uckert, W., Kammertoens, T., Haack, K., Qin, Z., Gebert, J., Schendel, D.J. and Blankenstein, T.
Human Gene Therapy 9
: 855-865.
1 January 1998
Large and small scale RNA preparations from eukaryotic cells.
Uckert, W., Walther, W. and Stein, U.
In:
RNA Isolation and Characterization Protocols.
Methods in Molecular Biology ; 86
.
Humana Press, Totowa,NJ, 7-14.
1 January 1998
Neutrophils but not eosinophils are involved in growth suppression of IL-4-secreting tumors.
Noffz, G., Qin, Z.H., Kopf, M. and Blankenstein, T.
Journal of Immunology 160
: 345-350.
1 January 1998
RNA levels of human retrovirus receptors Pit1 and Pit2 do not correlate with infectibility by three retroviral vector pseudotypes.
Uckert, W., Willimsky, G., Pedersen, F.S., Blankenstein, T. and Pedersen, L.
Human Gene Therapy 9
: 2619-2627.
1 January 1998
Retroviral B7.1 gene transfer in cancer cells protects cytotoxic T cells from deletion by "veto" apoptosis.
Daniel, P.T., Kroidl, A., Cayeux, S., Scholz, C., Sturm, I., Blankenstein, T., Pezzutto, A. and Doerken, B.
Advances in Experimental Medicine and Biology 451
: 265-276.
1 January 1998
Retroviral interleukin-7 gene transfer into human dendritic cells enhances T cell activation.
Westermann, J., Aicher, A., Qin, Z., Cayeux, S., Daemen, K., Blankenstein, T., Doerken, B. and Pezzutto, A.
Gene Therapy 5
: 264-271.
1 January 1998
Strong immunogenic potential of a B7 retroviral expression vector: Generation of HLA-B7-restricted CTL response against selectable marker genes.
Jung, D., Jaeger, E., Cayeux, S., Blankenstein, T., Hilmes, C., Karbach, J., Moebius, U., Knuth, A., Huber, C. and Seliger, B.
Human Gene Therapy 9
: 53-62.
1 January 1998
1997
Costimulatory signals through B7.1/CD28 prevent T cell apoptosis during target cell lysis.
Daniel, P.T., Kroidl, A., Cayeux, S., Bargou, R.C., Blankenstein, T. and Doerken, B.
Journal of Immunology 159
(8): 3808-3815.
15 October 1997
Interleukin-10 prevents dendritic cell accumulation and vaccination with granulocyte- macrophage colony-stimulating factor gene-modified tumor cells.
Qin, Z., Noffz, G., Mohaupt, M. and Blankenstein, T.
Journal of Immunology 159
(2): 770-776.
15 July 1997
Lebendvakzine zur Behandlung von Tumorerkrankungen [Live vaccine for the treatment of tumour diseases].
T. Blankenstein, S. Cayeux.
EP0777499A1 ; EP0777499B1 ; WO9605866A2 ; WO9605866A3 ; US6,039,941.
11 June 1997
Down regulation of the expression and function of the transporter associated with antigen processing in murine tumor cell lines expressing IL-10.
Salazar-Onfray, F., Charo, J., Petersson, M., Freland, S., Noffz, G., Qin, Z.H., Blankenstein, T., Ljunggren, H.G. and Kiessling, R.
Journal of Immunology 159
: 3195-3202.
1 January 1997
Influence of gene modified (IL 7, IL 4, and B7) tumor cell vaccines on tumor antigen presentation.
Cayeux, S., Richter, G., Noffz, G., Doerken, B. and Blankenstein, T.
Journal of Immunology 158
: 2834-2841.
1 January 1997
Lack of correlation between rejection of tumor cells co-expressing interleukin 2 and B7.1 and vaccine efficiency.
Cayeux, S., Richter, G., Becker, C., Beck, C., Aicher, A., Pezzutto, A., Doerken, B. and Blankenstein, T.
European Journal of Immunology 27
: 1657-1662.
1 January 1997
Loss of retroviral gene expression in bone marrow reconstituted mice correlates with down regulation of gene expression in long term culture initiating cells.
Lange, C. and Blankenstein, T.
Gene Therapy 4
: 303-308.
1 January 1997
Regulated gene expression after retroviral vector-mediated delivery of cancer-relevant therapeutic genes.
Guenzburg, W.H., Karle, P., Mrochen, S., Sparmann, G., Saller, R., Klein, D., Uckert, W. and Salmons, B.
Recent Results in Cancer Research 144
: 116-126.
1 January 1997
Successful retroviral mediated transduction of a receptor gene in human dendritic cells: feasibility of therapy with gene-modified antigen presenting cells.
Aicher, A., Westermann, J., Cayeux, S., Willimsky, G., Daemen, K., Blankenstein, T., Uckert, W., Doerken, B. and Pezzutto, A.
Experimental Hematology 25
: 39-44.
1 January 1997
Transient expression of SV 40 large T antigen by Cre/LoxP mediated site specific deletion in primary human tumor cells.
Li, L.P., Schlag, P.M. and Blankenstein, T.
Human Gene Therapy 8
: 1695-1700.
1 January 1997
Tumor cell vaccines using genetically modified cells coexpressing cytokines and the T cell costimulatory molecule B7.
Cayeux, S., Doerken, B. and Blankenstein, T.
In:
Concepts in Gene Therapy.
de Gruyter, Berlin [u.a.], 487-503.
1 January 1997
Methods for use of cytokine gene-modified tumor cells in immunotherapy of cancer.
Qin, Z. and Blankenstein, T.
Methods in Molecular Medicine 7
: 339-348.
1997
1996
Lebendvakzine gegen Tumorerkrankungen.
Blankenstein, T. and Cayeux-Pezzutto, S.
DE4431401A1.
29 February 1996
Attenuation of collagen induced-arthritis in mice by treatment with vector cells engineered to secrete interleukin-13.
Bessis, N., Boissie, M.C., Ferrara, P., Blankenstein, T., Fradelizi, D. and Fournier, C.
European Journal of Immunology 26
: 2399-2403.
1 January 1996
Cancer vaccines in gene therapy.
Blankenstein, T. and Qin, Z.
Gene Therapy 3
(2): 95-96.
1 January 1996
Coexpression of interleukin-4 and B7.1 in murine tumor cells leads to improved tumor rejection and vaccine effect compared to single gene transfectants and a classical adjuvant.
Cayeux, S., Beck, C., Doerken, B. and Blankenstein, T.
Human Gene Therapy 7
(4): 525-529.
1 January 1996
Genetic approaches to cancer immunotherapy.
Blankenstein, T., Cayeux, S. and Qin, Z.
Reviews of Physiology Biochemistry and Pharmacology 129
: 1-49.
1 January 1996
The influence of local cytokines on tumor metastasis: using cytokine gene transfected tumor cells as experimental models.
Qin, Z. and Blankenstein, T.
Current Topics in Microbiology and Immunology 213/III
: 55-64.
1 January 1996
Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein.
Brocke, S., Gijbels, K., Allegretta, M., Ferber, I., Piercy, C., Blankenstein, T., Martin, R., Utz, U., Karin, N., Mitchell, D., Veromaa, T., Waisman, A., Gaur, A., Conlon, P., Ling, N., Fairchild, P.J., Wraith, D.C., Ogarra, A., Fathman, C.G. and Steinman, L.
Nature 379
(6563): 343-346.
1 January 1996
1995
European school of oncology position paper - gene therapy for the medical oncologist.
Blaese, M., Blankenstein, T., Brenner, M., Cohenhaguenauer, O., Gansbacher, B., Sorrentino, B. and Velu, T.
European Journal of Cancer 31A
(9): 1531-1537.
1 January 1995
Human lymphotoxin has at least equal antitumor activity in comparison to human tumor necrosis factor but is less toxic in mice.
Qin, Z., van Tits, L.J.H., Buurman, W.A. and Blankenstein, T.
Blood 85
: 2779-2785.
1 January 1995
IL-10 converts mouse lymphoma cells to a CTL-resistant, nk-sensitive phenotype with low but peptide-inducible MHC class I expression.
Salazar-Onfray, F., Petersson, M., Franksson, L., Matsuda, M., Blankenstein, T., Karre, K. and Kiessling, R.
Journal of Immunology 154
(12): 6291-6298.
1 January 1995
Influence of retrovirally transduced human tumor-necrosis-factor-alpha on the expression of C-myc, k-ras, C-jun, p53, tgf-alpha, and cea in human colon-carcinoma cell-lines.
Uckert, W., Walther, W. and Hummel, O.
International Journal of Oncology 6
: 1027-1031.
1 January 1995
Polymerase chain reaction to quantitate cytokine mRNA.
Platzer, C. and Blankenstein, T.
In:
Cytokines : A Practical Approach.
Oxford University Press, New York, 57-68.
1 January 1995
The rat interleukin-4 receptor: coevolution of ligand and receptor.
Richter, G., Hein, G., Blankenstein, T. and Diamantstein, T.
Cytokine 7
: 237-241.
1 January 1995
The thymidine kinase/ganciclovir-mediated "suicide" effect is highly variable in different tumor cells.
Beck, C., Cayeux, S., Lupton, S., Doerken, B. and Blankenstein, T.
Human Gene Therapy 6
(12): 1525-1530.
1 January 1995
Tumor cells cotransfected with interleukin-7 and B7.1 genes induce CD25 and CD28 on tumor-infiltrating T lymphocytes and are strong vaccines.
Cayeux, S., Beck, C., Aicher, A., Doerken, B. and Blankenstein, T.
European Journal of Immunology 25
(8): 2325-2331.
1 January 1995
Tumor growth inhibition mediated by lymphotoxin: evidence of B lymphocyte involvement in the antitumor response.
Qin, Z. and Blankenstein, T.
Cancer Research 55
(21): 4747-4751.
1 January 1995
Vectors in cancer therapy: how will they deliver.
Blaese, M., Blankenstein, T., Brenner, M., Cohen-Haguenauer, O., Gansbacher, B., Russell, S., Sorrentino, B. and Velu, T.
Cancer Gene Therapy 2
(4): 291-297.
1 January 1995
1994
Conditional expression of human TNF-alpha: a system for inducible cytotoxicity.
Sparmann, G., Walther, W., Guenzburg, W.H., Uckert, W. and Salmons, B.
International Journal of Cancer 59
: 103-107.
1 January 1994
Detection of cytokines induced by and involved in the anti-tumor response provoked by tumor cell derived interleukin-4.
Richter, G., Platzer, C., Blankenstein, T. and Diamantstein, T.
In:
Cytokines in Cancer Therapy.
Contributions to Oncology ; 46
.
Karger, Basel, 281-285.
1 January 1994
Expression of interleukin 10 in human melanoma.
Krueger-Krasagakes, S., Krasagakis, K., Garbe, C., Schmitt, E., Huels, C., Blankenstein, T. and Diamantstein, T.
British Journal of Cancer 70
: 1182-1185.
1 January 1994
Immunizing and curative potential of replicating and nonreplicating murine mammary adenocarcinoma cells engineered with interleukin (IL)-2, IL-4, IL-6, IL-7, IL- 10, tumor necrosis factor alpha, granulocyte-macrophage colony-stimulating factor, and gamma-interferon gene or admixed with conventional adjuvants.
Allione, A., Consalvo, M., Nanni, P., Lollini, P.L., Cavallo, F., Giovarelli, M., Forni, M., Gulino, A., Colombo, M.P., Dellabona, P., Hock, H., Blankenstein, T., Rosenthal, F.M., Gansbacher, B., Bosco, M.C., Musso, T., Gusella, L. and Forni, G.
Cancer Research 54
: 6022-6026.
1 January 1994
Increasing tumour immunogenicity by genetic modification.
Blankenstein, T.
European Journal of Cancer 30A
: 1182-1187.
1 January 1994
Influence of different promoters on the expression of tumor necrosis factor alpha in LS174T human colon carcinoma cells.
Uckert, W., Asche, O., Mahanty, B. and Fichtner, I.
International Journal of Oncology 5
: 865-871.
1 January 1994
Observations with tumour necrosis factor gene-transfected tumours.
Blankenstein, T.
Folia Biologica Prague 40
: 19-28.
1 January 1994
Rejection of IL-7 gene transfected tumors.
Blankenstein, T., Hock, H., Dorsch, M. and Diamantstein, T.
In:
Cytokine-Induced Tumor Immunogenicity: From Exogenous Molecules to Gene Therapy.
Acad.Press, New York, 217-231.
1 January 1994
Retrovirus-mediated gene transfer in cancer therapy.
Uckert, W. and Walther, W.
Pharmacology & Therapeutics 63
: 323-347.
1 January 1994
Tumor cell targeted IL7 gene transfer reveals T cell-dependent anti-tumor activity in vivo.
Hock, H., Dorsch, M., Blankenstein, T. and Diamantstein, T.
In:
Cytokines in Cancer Therapy.
Contributions to Oncology ; 46
.
Karger, Basel, 277-280.
1 January 1994
Tumor-cell-targeted cytokine gene transfer in experimental models for cancer therapy.
Hock, H., Dorsch, M., Richter, G., Kunzendorf, U., Krueger-Krasagakes, S., Blankenstein, T., Qin, Z.H. and Diamantstein, T.
Natural Immunity 13
: 85-92.
1 January 1994
1993
Interleukin 10 transfected into Chinese hamster ovary cells prevents tumor growth and macrophage infiltration.
Richter, G., Krueger-Krasagakes, S., Hein, G., Huels, C., Schmitt, E., Diamantstein, T. and Blankenstein, T.
Cancer Research 53
(18): 4134-4137.
15 September 1993
Lymphotoxin, tumour necrosis factor and interleukin-6 gene transcripts are present in Hodgkin and Reed-Sternberg cells of most Hodgkin's disease cases.
Foss, H.D., Herbst, H., Oelmann, E., Samol, J., Grebe, M., Blankenstein, T., Matthes, J., Qin, Z., Falini, B., Pileri, S., Diamantstein, T. and Stein, H.
British Journal of Haematology 84
(4): 627-635.
1 August 1993
Expression of tumor necrosis factor by different tumor cell lines results either in tumor suppression or augmented metastasis.
Qin, Z., Krueger-Krasagakes, S., Kunzendorf, U., Hock, H., Diamantstein, T. and Blankenstein, T.
Journal of Experimental Medicine 178
(1): 355-360.
1 July 1993
Rapid method of total RNA mini-preparation from eucaryotic cells.
Walther, W., Stein, U. and Uckert, W.
Nucleic Acids Research 21
(7): 1682.
11 April 1993
Mechanisms of rejection induced by tumor cell-targeted gene transfer of interleukin 2, interleukin 4, interleukin 7, tumor necrosis factor, or interferon-gamma.
Hock, H., Dorsch, M., Kunzendorf, U., Qin, Z., Diamantstein, T. and Blankenstein, T.
Proceedings of the National Academy of Sciences of the United States of America 90
(7): 2774-2778.
1 April 1993
Vaccinations with tumor cells genetically engineered to produce different cytokines: effectivity not superior to a classical adjuvant.
Hock, H., Dorsch, M., Kunzendorf, U., Ueberla, K., Qin, Z., Diamantstein, T. and Blankenstein, T.
Cancer Research 53
(4): 714-716.
15 February 1993
Cytokine involvement in tumor development and tumor suppression.
Dorsch, M., Diamantstein, T. and Blankenstein, T.
In:
Cytokines in Hemopoiesis, Oncology, and AIDS II.
Springer, Berlin, 87-92.
1 January 1993
Eosinophils infiltrating interleukin-5 gene-transfected tumors do not suppress tumor growth.
Krueger-Krasagakes, S., Li, W., Richter, G., Diamantstein, T. and Blankenstein, T.
European Journal of Immunology 23
: 992-995.
1 January 1993
Humaner Tumor-Nekrose-Faktor-alpha: Konzentrationsbestimmung in Kulturueberstaenden mittels ELISA.
Asche, O. and Uckert, W.
Biochemica-Information 90
: 20-22.
1 January 1993
Macrophage colony-stimulating factor gene transfer into tumor cells induces macrophage infiltration but not tumor suppression.
Dorsch, M., Hock, H., Kunzendorf, U., Diamantstein, T. and Blankenstein, T.
European Journal of Immunology 23
: 186-190.
1 January 1993
Retrovirus-mediated gene transfer of tumor necrosis factor alpha into colon carcinoma cells generates a growth inhibition.
Walther, W., Fichtner, I. and Uckert, W.
Anticancer Research 13
: 1565-1574.
1 January 1993
1992
Kinetic analysis of cytokine gene expression in the livers of naive and immune mice infected with Listeria monocytogenes. The immediate early phase in innate resistance and acquired immunity.
Ehlers, S., Mielke, M.E., Blankenstein, T. and Hahn, H.
Journal of Immunology 149
(9): 3016-3022.
1 November 1992
Abnormal TNF production in prediabetic BB rats is linked to defective CD45R expression.
Rothe, H., Schuller, I., Richter, G., Jongeneel, C.V., Kiesel, U., Diamantstein, T., Blankenstein, T. and Kolb, H.
Immunology 77
(1): 1-6.
1 January 1992
Analysis of cytokine mRNA levels in interleukin-4-transgenic mice by quantitative polymerase chain reaction.
Platzer, C., Richter, G., Ueberla, K., Mueller, W., Bloecker, H., Diamantstein, T. and Blankenstein, T.
European Journal of Immunology 22
(5): 1179-1184.
1 January 1992
Interleukin-4-mediated tumor suppression in nude mice involves interferon-gamma.
Platzer, C., Richter, G., Ueberla, K., Hock, H., Diamantstein, T. and Blankenstein, T.
European Journal of Immunology 22
(7): 1729-1733.
1 January 1992
Retroviral transduction of the human TNF alpha gene into tumour cells generates a growth inhibitory effect.
Walther, W., Huth, J., Sparmann, G. and Uckert, W.
In:
European Biotechnology Today.
INTERCEPT Ltd., Andover, 209-216.
1 January 1992
1991
Inhibition of the TPA-induction of simian sarcoma virus by an antisense v-jun oncogene.
Stein, U., Wunderlich, V. and Uckert, W.
Archiv fuer Geschwulstforschung 61
: 163-169.
1 January 1991
This list was generated on Wed Nov 20 19:51:38 2024 UTC.
![[feed]](/style/images/feed-icon-14x14.png){kind=icon}
