Browse by Research Team

Research Teams (255)
- Blankenstein, Thomas (255)

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Advances in Cancer Research

Chemical carcinogens as foreign bodies and some pitfalls regarding cancer immune surveillance.
Blankenstein, T. and Qin, Z.
Advances in Cancer Research 90 : 179-207. 2003

Advances in Experimental Medicine and Biology

Retroviral B7.1 gene transfer in cancer cells protects cytotoxic T cells from deletion by "veto" apoptosis.
Daniel, P.T., Kroidl, A., Cayeux, S., Scholz, C., Sturm, I., Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321, Pezzutto, A. ORCID: https://orcid.org/0000-0002-3246-4470 and Doerken, B. ORCID: https://orcid.org/0000-0001-7991-3643
Advances in Experimental Medicine and Biology 451 : 265-276. 1 January 1998

Anticancer Research

Retrovirus-mediated gene transfer of tumor necrosis factor alpha into colon carcinoma cells generates a growth inhibition.
Walther, W. ORCID: https://orcid.org/0000-0003-2884-0231, Fichtner, I. and Uckert, W.
Anticancer Research 13 : 1565-1574. 1 January 1993

Archiv fuer Geschwulstforschung

Inhibition of the TPA-induction of simian sarcoma virus by an antisense v-jun oncogene.
Stein, U. ORCID: https://orcid.org/0000-0001-7006-282X, Wunderlich, V. and Uckert, W.
Archiv fuer Geschwulstforschung 61 : 163-169. 1 January 1991

Arzneimittelforschung

Spontaneous and therapy-induced T cell responses to cancer.
Blankenstein, T.
Arzneimittelforschung 62 (1): S9. November 2012

BMC Bioinformatics

SigsPack, a package for cancer mutational signatures.
Schumann, F., Blanc, E. ORCID: https://orcid.org/0000-0002-4369-0254, Messerschmidt, C. ORCID: https://orcid.org/0000-0001-8632-656X, Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321, Busse, A. ORCID: https://orcid.org/0000-0002-3470-6947 and Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632
BMC Bioinformatics 20 (1): 450. 2 September 2019

BMC Infectious Diseases

Visceral leishmaniasis diagnosis and reporting delays as an obstacle to timely response actions in Nepal and India.
Boettcher, J.P., Siwakoti, Y., Milojkovic, A., Siddiqui, N.A., Gurung, C.K., Rijal, S., Das, P., Kroeger, A. and Banjara, M.R.
BMC Infectious Diseases 15 (1): 43. 6 February 2015

BMC Medical Genomics

Identification and ranking of recurrent neo-epitopes in cancer.
Blanc, E. ORCID: https://orcid.org/0000-0002-4369-0254, Holtgrewe, M. ORCID: https://orcid.org/0000-0002-3051-1763, Dhamodaran, A. ORCID: https://orcid.org/0000-0001-7711-9593, Messerschmidt, C. ORCID: https://orcid.org/0000-0001-8632-656X, Willimsky, G. ORCID: https://orcid.org/0000-0002-9693-948X, Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321 and Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632
BMC Medical Genomics 12 : 171. 27 November 2019

BioForum

Gentherapie mit T-Zellrezeptor modifizierten Zellen.
Uckert, W. and Blankenstein, T.
BioForum 28 (3): 27-30. 20 May 2005

Biochemica-Information

Humaner Tumor-Nekrose-Faktor-alpha: Konzentrationsbestimmung in Kulturueberstaenden mittels ELISA.
Asche, O. and Uckert, W.
Biochemica-Information 90 : 20-22. 1 January 1993

Biochimica et Biophysica Acta - Gene Regulatory Mechanisms

Molecular contacts of ribose-phosphate backbone of mRNA with human ribosome.
Sharifulin, D.E., Grosheva, A.S., Bartuli, Y.S., Malygin, A.A., Meschaninova, M.I., Ven'yaminova, A.G., Stahl, J., Graifer, D.M. and Karpova, G.G.
Biochimica et Biophysica Acta - Gene Regulatory Mechanisms 1849 (8): 930-939. August 2015

Blood

Virus-reactive T cells expanded in aplastic anemia eliminate hematopoietic progenitor cells by molecular mimicry.
Ben Hamza, A., Welters, C., Stadler, S., Brüggemann, M., Dietze, K., Brauns, O., Brümmendorf, T.H., Winkler, T.H., Bullinger, L. ORCID: https://orcid.org/0000-0002-5890-5510, Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321, Rosenberger, L., Leisegang, M., Kammertöns, T., Herr, W., Moosmann, A., Strobel, J., Hackstein, H., Dornmair, K., Beier, F. and Hansmann, L.
Blood 143 (14): 1365-1378. 4 April 2024

Oncogene-specific T cells fail to eradicate lymphoma-initiating B cells in mice.
Hoser, D., Schön, C., Loddenkemper, C., Lohneis, P., Kühl, A.A., Sommermann, T. ORCID: https://orcid.org/0000-0003-2899-0256, Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321 and Willimsky, G. ORCID: https://orcid.org/0000-0002-9693-948X
Blood 132 (9): 924-934. 30 August 2018

Differently immunogenic cancers in mice induce immature myeloid cells that suppress CTL in vitro but not in vivo following transfer.
Schmidt, K. ORCID: https://orcid.org/0000-0002-0572-6199, Zilio, S., Schmollinger, J.C., Bronte, V., Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321 and Willimsky, G. ORCID: https://orcid.org/0000-0002-9693-948X
Blood 121 (10): 1740-1748. 7 March 2013

The only proposed T-cell epitope derived from the TEL-AML1 translocation is not naturally processed.
Popovic, J., Li, L.P., Kloetzel, P.M., Leisegang, M. ORCID: https://orcid.org/0000-0003-3692-7142, Uckert, W. and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Blood 118 (4): 946-954. 28 July 2011

Active MAC-1 (CD11b/CD18) on DC is inhibitory for full T cell activation.
Varga, G., Balkow, S., Wild, M.K., Stadtbaeumer, A., Krummen, M., Rothoeft, T., Higuchi, T., Beissert, S., Wethmar, K., Scharffetter-Kochanek, K., Vestweber, D. and Grabbe, S.
Blood 109 (2): 661-669. 15 January 2007

Graft-versus-host disease after allogeneic hematopoietic stem cell transplantation induces a CD8+ T cell-mediated graft-versus-tumor effect that is independent of the recognition of alloantigenic tumor targets.
Stelljes, M., Strothotte, R., Pauels, H.G., Poremba, C., Milse, M., Specht, C., Albring, J., Bisping, G., Scheffold, C., Kammertoens, T. ORCID: https://orcid.org/0000-0003-3309-5141, Oelmann, E., Silling, G., Berdel, W.E. and Kienast, J.
Blood 104 (4): 1210-1216. 1 January 2004

Human lymphotoxin has at least equal antitumor activity in comparison to human tumor necrosis factor but is less toxic in mice.
Qin, Z., van Tits, L.J.H., Buurman, W.A. and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Blood 85 : 2779-2785. 1 January 1995

Bone Marrow Transplantation

Allogeneic vaccination for renal cell carcinoma: development and monitoring.
Pohla, H., Frankenberger, B., Stadlbauer, B., Oberneder, R., Hofstetter, A., Willimsky, G. ORCID: https://orcid.org/0000-0002-9693-948X, Pezzutto, A. ORCID: https://orcid.org/0000-0002-3246-4470, Doerken, B. ORCID: https://orcid.org/0000-0001-7991-3643, Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321 and Schendel, D.J.
Bone Marrow Transplantation 25 Suppl. 2 (3332): S83-S87. 1 May 2000

Bcr/abl+ autologous dendritic cells for vaccination in chronic myeloid leukemia.
Westermann, J., Kopp, J., Koerner, I., Richter, G., Qin, Z., Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321, Doerken, B. ORCID: https://orcid.org/0000-0001-7991-3643 and Pezzutto, A. ORCID: https://orcid.org/0000-0002-3246-4470
Bone Marrow Transplantation 25 Suppl. 2 (3332): S46-S49. 1 May 2000

British Journal of Cancer

Expression of interleukin 10 in human melanoma.
Krueger-Krasagakes, S., Krasagakis, K., Garbe, C., Schmitt, E., Huels, C., Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321 and Diamantstein, T.
British Journal of Cancer 70 : 1182-1185. 1 January 1994

British Journal of Haematology

Lymphotoxin, tumour necrosis factor and interleukin-6 gene transcripts are present in Hodgkin and Reed-Sternberg cells of most Hodgkin's disease cases.
Foss, H.D., Herbst, H., Oelmann, E., Samol, J., Grebe, M., Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321, Matthes, J., Qin, Z., Falini, B., Pileri, S., Diamantstein, T. and Stein, H.
British Journal of Haematology 84 (4): 627-635. 1 August 1993

Cancer Cell

It's the peptide-MHC affinity, stupid.
Kammertoens, T. ORCID: https://orcid.org/0000-0003-3309-5141 and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Cancer Cell 23 (4): 429-431. 15 April 2013

Oncogene-targeting T cells reject large tumors while oncogene inactivation selects escape variants in mouse models of cancer.
Anders, K. ORCID: https://orcid.org/0000-0002-0429-200X, Buschow, C., Herrmann, A., Milojkovic, A., Loddenkemper, C., Kammertoens, T. ORCID: https://orcid.org/0000-0003-3309-5141, Daniel, P., Yu, H., Charo, J. ORCID: https://orcid.org/0000-0002-5409-9160 and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Cancer Cell 20 (6): 755-767. 13 December 2011

Cancer Gene Therapy

Combined chemotherapy of murine mammary tumors by local activation of the prodrugs ifosfamide and 5-fluorocytosine.
Kammertoens, T. ORCID: https://orcid.org/0000-0003-3309-5141, Gelbmann, W., Karle, P., Alton, K., Saller, R., Salmons, B., Guenzburg, W.H. and Uckert, W.
Cancer Gene Therapy 7 (4): 629-636. 1 April 2000

Vectors in cancer therapy: how will they deliver.
Blaese, M., Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321, Brenner, M., Cohen-Haguenauer, O., Gansbacher, B., Russell, S., Sorrentino, B. and Velu, T.
Cancer Gene Therapy 2 (4): 291-297. 1 January 1995

Cancer Immunology Immunotherapy

HER-2/neu mediated down-regulation of MHC class I antigen processing prevents CTL-mediated tumor recognition upon DNA vaccination in HLA-A2 transgenic mice.
Vertuani, S., Triulzi, C., Roos, A.K., Charo, J. ORCID: https://orcid.org/0000-0002-5409-9160, Norell, H., Lemonnier, F., Pisa, P., Seliger, B. and Kiessling, R.
Cancer Immunology Immunotherapy 58 (5): 653-664. May 2009

Cancer Immunology Research

A transgenic dual-luciferase reporter mouse for longitudinal and functional monitoring of T cells in vivo.
Szyska, M. ORCID: https://orcid.org/0000-0002-4213-4600, Herda, S., Althoff, S., Heimann, A., Russ, J., D'Abundo, D., Dang, T.M., Durieux, I., Dörken, B. ORCID: https://orcid.org/0000-0001-7991-3643, Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321 and Na, I.K. ORCID: https://orcid.org/0000-0001-9902-5424
Cancer Immunology Research 6 (1): 110-120. January 2018

Tumor-infiltrating merkel cell polyomavirus-specific T cells are diverse and associated with improved patient survival.
Miller, N.J., Church, C.D., Dong, L., Crispin, D., Fitzgibbon, M.P., Lachance, K., Jing, L., Shinohara, M., Gavvovidis, I. ORCID: https://orcid.org/0000-0001-5644-9788, Willimsky, G. ORCID: https://orcid.org/0000-0002-9693-948X, McIntosh, M., Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321, Koelle, D.M. and Nghiem, P.
Cancer Immunology Research 5 (2): 137-147. February 2017

Cancer Letters

Ablation of TNF or lymphotoxin signaling and the frequency of spontaneous tumors in p53-deficient mice.
Kuprash, D.V., Qin, Z., Ito, D., Grivennikov, S.I., Abe, K., Drutskaya, L.N., Blankenstein, T. and Nedospasov, S.A.
Cancer Letters 268 (1): 70-75. 8 September 2008

Cancer Medicine

IL-13 but not IL-4 signaling via IL-4Rα protects mice from papilloma formation during DMBA/TPA two-step skin carcinogenesis.
Rothe, M. ORCID: https://orcid.org/0000-0002-6813-4705, Quarcoo, D., Chashchina, A.A., Bozrova, S.V. ORCID: https://orcid.org/0000-0001-7519-0900, Qin, Z., Nedospasov, S.A., Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321, Kammertoens, T. ORCID: https://orcid.org/0000-0003-3309-5141 and Drutskaya, M.S.
Cancer Medicine 2 (6): 815-825. December 2013

Cancer Research

ERAP1-dependent antigen cross-presentation determines efficacy of adoptive T cell therapy in mice.
Schmidt, K. ORCID: https://orcid.org/0000-0002-0572-6199, Keller, C., Kühl, A.A., Textor, A., Seifert, U., Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321, Willimsky, G. ORCID: https://orcid.org/0000-0002-9693-948X and Kloetzel, P.M.
Cancer Research 78 (12): 3243-3254. June 2018

CTLA4 promotes Tyk2-STAT3 dependent B-cell oncogenecity.
Herrmann, A., Lahtz, C., Nagao, T., Song, J.Y., Chan, W.C., Lee, H., Yue, C., Look, T., Muelfarth, R., Li, W., Jenkins, K., Williams, J., Budde, L.E., Forman, S.J., Kwak, L.W., Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321 and Yu, H.
Cancer Research 77 (18): 5118-5128. 15 September 2017

Efficacy of CAR T-cell therapy in large tumors relies upon stromal targeting by IFNγ.
Textor, A., Listopad, J.J., Wührmann, L.L., Perez, C., Kruschinski, A., Chmielewski, M., Abken, H., Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321 and Charo, J. ORCID: https://orcid.org/0000-0002-5409-9160
Cancer Research 74 (23): 6796-6805. 1 December 2014

Vaccine-instructed intratumoral IFN-γ enables regression of autochthonous mouse prostate cancer in allogeneic T cell transplantation.
Hess Michelini, R., Manzo, T., Sturmheit, T., Basso, V., Rocchi, M., Freschi, M., Listopad, J.J., Blankenstein, T., Bellone, M. and Mondino, A.
Cancer Research 73 (15): 4641-4652. 1 August 2013

Fibroblast-specific protein 1/S100A4-positive cells prevent carcinoma through collagen production and encapsulation of carcinogens.
Zhang, J, Chen, L, Liu, X, Kammertoens, T. ORCID: https://orcid.org/0000-0003-3309-5141, Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321 and Qin, Z.
Cancer Research 73 (9): 2770-2781. 1 May 2013

Tumor necrosis factor receptor 2-mediated tumor suppression is nitric oxide dependent and involves angiostasis.
Zhao, X., Mohaupt, M., Jiang, J., Liu, S., Li, B. and Qin, Z.
Cancer Research 67 (9): 4443-4450. 1 May 2007

CY15, a malignant histiocytic tumor that is phenotypically similar to immature dendritic cells.
Kammertoens, T. ORCID: https://orcid.org/0000-0003-3309-5141, Willebrand, R., Erdmann, B., Li, L., Li, Y., Engels, B., Uckert, W. and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Cancer Research 65 : 2560-2564. 1 January 2005

A critical requirement of interferon gamma-mediated angiostasis for tumor rejection by CD8T cells.
Qin, Z.H., Schwartzkopff, J., Pradera, F., Kammertoens, T. ORCID: https://orcid.org/0000-0003-3309-5141, Seliger, B., Pircher, H. and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Cancer Research 63 (14): 4095-4100. 1 January 2003

Increased tumorigenicity, but unchanged immunogenicity, of transporter for antigen presentation 1-deficient tumors.
Qin, Z., Harders, C., Cao, X., Huber, C., Blankenstein, T. and Seliger, B.
Cancer Research 62 (10): 2856-2860. 15 May 2002

Characterization of the major histocompatibility complex class I deficiencies in B16 melanoma cells.
Seliger, B., Wollscheid, U., Momburg, F., Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321 and Huber, C.
Cancer Research 61 : 1095-1099. 1 January 2001

Interleukin-7/B7.1-encoding adenoviruses induce rejection of transplanted but not nontransplanted tumors.
Willimsky, G. ORCID: https://orcid.org/0000-0002-9693-948X and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Cancer Research 60 (3): 685-692. 1 February 2000

Mitochondrial amplification of death signals determines thymidine kinase/ ganciclovir-triggered activation of apoptosis.
Beltinger, C., Fulda, S., Kammertoens, T. ORCID: https://orcid.org/0000-0003-3309-5141, Uckert, W. and Debatin, K.M.
Cancer Research 60 (12): 3212-3217. 1 January 2000

Tumor growth inhibition mediated by lymphotoxin: evidence of B lymphocyte involvement in the antitumor response.
Qin, Z. and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Cancer Research 55 (21): 4747-4751. 1 January 1995

Immunizing and curative potential of replicating and nonreplicating murine mammary adenocarcinoma cells engineered with interleukin (IL)-2, IL-4, IL-6, IL-7, IL- 10, tumor necrosis factor alpha, granulocyte-macrophage colony-stimulating factor, and gamma-interferon gene or admixed with conventional adjuvants.
Allione, A., Consalvo, M., Nanni, P., Lollini, P.L., Cavallo, F., Giovarelli, M., Forni, M., Gulino, A., Colombo, M.P., Dellabona, P., Hock, H., Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321, Rosenthal, F.M., Gansbacher, B., Bosco, M.C., Musso, T., Gusella, L. and Forni, G.
Cancer Research 54 : 6022-6026. 1 January 1994

Interleukin 10 transfected into Chinese hamster ovary cells prevents tumor growth and macrophage infiltration.
Richter, G., Krueger-Krasagakes, S., Hein, G., Huels, C., Schmitt, E., Diamantstein, T. and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Cancer Research 53 (18): 4134-4137. 15 September 1993

Vaccinations with tumor cells genetically engineered to produce different cytokines: effectivity not superior to a classical adjuvant.
Hock, H., Dorsch, M., Kunzendorf, U., Ueberla, K., Qin, Z., Diamantstein, T. and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Cancer Research 53 (4): 714-716. 15 February 1993

Cancers

CD28 co-stimulus achieves superior CAR T cell effector function against solid tumors than 4-1BB co-stimulus.
Textor, A., Grunewald, L., Anders, K. ORCID: https://orcid.org/0000-0002-0429-200X, Klaus, A., Schwiebert, S., Winkler, A., Stecklum, M., Rolff, J., Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X, Höpken, U.E. ORCID: https://orcid.org/0000-0002-0776-4893, Eggert, A., Schulte, J.H. ORCID: https://orcid.org/0000-0003-0671-1201, Jensen, M.C., Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321 and Künkele, A. ORCID: https://orcid.org/0000-0002-8406-5412
Cancers 13 (5): 1050. 2 March 2021

Cell Reports

Early life stress regulates cardiac development through an IL4-glucocorticoid signaling balance.
Apaydin, D.C., Jaramillo, P.A.M., Corradi, L. ORCID: https://orcid.org/0000-0001-8837-6544, Cosco, F., Rathjen, F.G. ORCID: https://orcid.org/0000-0001-5351-613X, Kammertoens, T. ORCID: https://orcid.org/0000-0003-3309-5141, Filosa, A. ORCID: https://orcid.org/0000-0003-2599-6951 and Sawamiphak, S. ORCID: https://orcid.org/0000-0003-2298-3565
Cell Reports 33 (7): 108404. 17 November 2020

Circulation

Nicotine strongly activates dendritic cell-mediated adaptive immunity - Potential role for progression of atherosclerotic lesions.
Aicher, A., Heeschen, C., Mohaupt, M., Cooke, J.P., Zeiher, A.M. and Dimmeler, S.
Circulation 107 (4): 604-611. 4 February 2003

Clinical Cancer Research

Targeting Merkel cell carcinoma by engineered T cells specific to T-antigens of Merkel cell polyomavirus.
Gavvovidis, I. ORCID: https://orcid.org/0000-0001-5644-9788, Leisegang, M. ORCID: https://orcid.org/0000-0003-3692-7142, Willimsky, G. ORCID: https://orcid.org/0000-0002-9693-948X, Miller, N.J., Nghiem, P. and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Clinical Cancer Research 24 (15): 3644-3655. August 2018

T cell receptors for clinical therapy: in vitro assessment of toxicity risk.
Kunert, A., Obenaus, M. ORCID: https://orcid.org/0000-0002-5090-9162, Lamers, C.H.J., Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321 and Debets, R.
Clinical Cancer Research 23 (20): 6012-6020. 15 October 2017

Molecular pathways: comparing the effects of drugs and T cells to effectively target oncogenes.
Anders, K. ORCID: https://orcid.org/0000-0002-0429-200X and Blankenstein, T.
Clinical Cancer Research 19 (2): 320-326. 15 January 2013

T-cell receptor gene-modified T cells with shared renal cell carcinoma specificity for adoptive T-cell therapy.
Leisegang, M. ORCID: https://orcid.org/0000-0003-3692-7142, Turqueti-Neves, A., Engels, B. ORCID: https://orcid.org/0000-0001-9682-2954, Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321, Schendel, D.J., Uckert, W. and Noessner, E.
Clinical Cancer Research 16 (8): 2333-2343. 15 April 2010

Influence of CD80, interleukin-2, and interleukin-7 expression in human renal cell carcinoma on the expansion, function, and survival of tumor-specific CTLs.
Frankenberger, B., Pohla, H., Noessner, E., Willimsky, G. ORCID: https://orcid.org/0000-0002-9693-948X, Papier, B., Pezzutto, A. ORCID: https://orcid.org/0000-0002-3246-4470, Kopp, J., Oberneder, R., Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321 and Schendel, D.J.
Clinical Cancer Research 11 : 1733-1742. 1 January 2005

Current Opinion in Immunology

The role of CD4 T cells in rejection of solid tumors.
Poncette, L. ORCID: https://orcid.org/0000-0001-8300-3968, Bluhm, J. and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Current Opinion in Immunology 74 : 18-24. February 2022

Targeting cancer-specific mutations by T cell receptor gene therapy.
Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321, Leisegang, M. ORCID: https://orcid.org/0000-0003-3692-7142, Uckert, W. and Schreiber, H.
Current Opinion in Immunology 33 : 112-119. April 2015

The role of tumor stroma in the interaction between tumor and immune system.
Blankenstein, T.
Current Opinion in Immunology 17 (2): 180-186. 1 January 2005

The role of IFN-gamma in tumor transplantation immunity and inhibition of chemical carcinogenesis.
Blankenstein, T. and Qin, Z.H.
Current Opinion in Immunology 15 (2): 148-154. April 2003

Current Topics in Microbiology and Immunology

The influence of local cytokines on tumor metastasis: using cytokine gene transfected tumor cells as experimental models.
Qin, Z. and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Current Topics in Microbiology and Immunology 213/III : 55-64. 1 January 1996

Cytokine

Differences in serum cytokine levels between wild type mice and mice with a targeted mutation suggests necessity of using control littermates.
Briesemeister, D., Friese, C., Isern, C.C., Dietz, E., Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321, Thoene-Reineke, C. and Kammertoens, T. ORCID: https://orcid.org/0000-0003-3309-5141
Cytokine 60 (3): 626-633. December 2012

The rat interleukin-4 receptor: coevolution of ligand and receptor.
Richter, G., Hein, G., Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321 and Diamantstein, T.
Cytokine 7 : 237-241. 1 January 1995

Cytotherapy

EMBO Journal

Heat shock factor 1 ameliorates proteotoxicity in cooperation with the transcription factor NFAT.
Hayashida, N., Fujimoto, M., Tan, K., Prakasam, R., Shinkawa, T., Li, L., Ichikawa, H., Takii, R. and Nakai, A.
EMBO Journal 29 (20): 3459-3469. 20 October 2010

EMBO Molecular Medicine

"Designer cytokines" targeting the tumor vasculature - think global and act local.
Kammertoens, T. ORCID: https://orcid.org/0000-0003-3309-5141, Kemna, J. ORCID: https://orcid.org/0000-0002-2172-4441 and Leisegang, M. ORCID: https://orcid.org/0000-0003-3692-7142
EMBO Molecular Medicine 12 (2): e11801. 7 February 2020

European Journal of Cancer

European school of oncology position paper - gene therapy for the medical oncologist.
Blaese, M., Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321, Brenner, M., Cohenhaguenauer, O., Gansbacher, B., Sorrentino, B. and Velu, T.
European Journal of Cancer 31A (9): 1531-1537. 1 January 1995

Increasing tumour immunogenicity by genetic modification.
Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
European Journal of Cancer 30A : 1182-1187. 1 January 1994

European Journal of Immunology

Misinitiation of intrathymic MART-1 transcription and biased TCR usage explain the high frequency of MART-1-specific T cells.
Pinto, S., Sommermeyer, D., Michel, C., Wilde, S., Schendel, D., Uckert, W., Blankenstein, T. and Kyewski, B.
European Journal of Immunology 44 (9): 2811-2821. September 2014

Visualizing the dynamic of adoptively transferred T cells during the rejection of large established tumors.
Charo, J. ORCID: https://orcid.org/0000-0002-5409-9160, Perez, C., Buschow, C., Jukica, A., Czeh, M. and Blankenstein, T.
European Journal of Immunology 41 (11): 3187-3197. November 2011

Commensal microflora and interferon-gamma promote steady-state interleukin-7 production in vivo.
Shalapour, S., Deiser, K., Sercan, O., Tuckermann, J., Minnich, K., Willimsky, G. ORCID: https://orcid.org/0000-0002-9693-948X, Blankenstein, T., Haemmerling, G.J., Arnold, B. and Schueler, T.
European Journal of Immunology 40 (9): 2391-2400. September 2010

Making and circumventing tolerance to cancer.
Kammertoens, T. ORCID: https://orcid.org/0000-0003-3309-5141 and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
European Journal of Immunology 39 (9): 2345-2353. September 2009

Designer T cells by T cell receptor replacement.
Sommermeyer, D., Neudorfer, J., Weinhold, M., Leisegang, M. ORCID: https://orcid.org/0000-0003-3692-7142, Engels, B. ORCID: https://orcid.org/0000-0001-9682-2954, Noessner, E., Heemskerk, M.H., Charo, J. ORCID: https://orcid.org/0000-0002-5409-9160, Schendel, D.J., Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321, Bernhard, H. and Uckert, W.
European Journal of Immunology 36 (11): 3052-3059. November 2006

Migration of immature mouse DC across resting endothelium is mediated by ICAM-2 but independent of beta2-integrins and murine DC-SIGN homologues.
Wethmar, K., Helmus, Y., Luehn, K., Jones, C., Laskowska, A., Varga, G., Grabbe, S., Lyck, R., Engelhardt, B., Bixel, M.G., Butz, S., Loser, K., Beissert, S., Ipe, U., Vestweber, D. and Wild, M.K.
European Journal of Immunology 36 (10): 2781-2794. October 2006

Dual T cell receptor T cells with two defined specificities mediate tumor suppression via both receptors.
Gladow, M., Uckert, W. and Blankenstein, T.
European Journal of Immunology 34 (7): 1882-1891. 1 July 2004

Decreased generation of anti-tumor immunity after intrasplenic immunization.
Cayeux, S., Qin, Z.H., Doerken, B. ORCID: https://orcid.org/0000-0001-7991-3643 and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
European Journal of Immunology 31 (5): 1392-1399. 1 January 2001

Direct and indirect T cell priming by dendritic cell vaccines.
Cayeux, S., Richter, G., Becker, C., Pezzutto, A. ORCID: https://orcid.org/0000-0002-3246-4470, Doerken, B. ORCID: https://orcid.org/0000-0001-7991-3643 and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
European Journal of Immunology 29 : 225-234. 1 January 1999

Lack of correlation between rejection of tumor cells co-expressing interleukin 2 and B7.1 and vaccine efficiency.
Cayeux, S., Richter, G., Becker, C., Beck, C., Aicher, A., Pezzutto, A. ORCID: https://orcid.org/0000-0002-3246-4470, Doerken, B. ORCID: https://orcid.org/0000-0001-7991-3643 and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
European Journal of Immunology 27 : 1657-1662. 1 January 1997

Attenuation of collagen induced-arthritis in mice by treatment with vector cells engineered to secrete interleukin-13.
Bessis, N., Boissie, M.C., Ferrara, P., Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321, Fradelizi, D. and Fournier, C.
European Journal of Immunology 26 : 2399-2403. 1 January 1996

Tumor cells cotransfected with interleukin-7 and B7.1 genes induce CD25 and CD28 on tumor-infiltrating T lymphocytes and are strong vaccines.
Cayeux, S., Beck, C., Aicher, A., Doerken, B. ORCID: https://orcid.org/0000-0001-7991-3643 and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
European Journal of Immunology 25 (8): 2325-2331. 1 January 1995

Eosinophils infiltrating interleukin-5 gene-transfected tumors do not suppress tumor growth.
Krueger-Krasagakes, S., Li, W., Richter, G., Diamantstein, T. and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
European Journal of Immunology 23 : 992-995. 1 January 1993

Macrophage colony-stimulating factor gene transfer into tumor cells induces macrophage infiltration but not tumor suppression.
Dorsch, M., Hock, H., Kunzendorf, U., Diamantstein, T. and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
European Journal of Immunology 23 : 186-190. 1 January 1993

Analysis of cytokine mRNA levels in interleukin-4-transgenic mice by quantitative polymerase chain reaction.
Platzer, C., Richter, G., Ueberla, K., Mueller, W., Bloecker, H., Diamantstein, T. and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
European Journal of Immunology 22 (5): 1179-1184. 1 January 1992

Interleukin-4-mediated tumor suppression in nude mice involves interferon-gamma.
Platzer, C., Richter, G., Ueberla, K., Hock, H., Diamantstein, T. and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
European Journal of Immunology 22 (7): 1729-1733. 1 January 1992

Experimental Hematology

Successful retroviral mediated transduction of a receptor gene in human dendritic cells: feasibility of therapy with gene-modified antigen presenting cells.
Aicher, A., Westermann, J., Cayeux, S., Willimsky, G. ORCID: https://orcid.org/0000-0002-9693-948X, Daemen, K., Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321, Uckert, W., Doerken, B. ORCID: https://orcid.org/0000-0001-7991-3643 and Pezzutto, A. ORCID: https://orcid.org/0000-0002-3246-4470
Experimental Hematology 25 : 39-44. 1 January 1997

FASEB Journal

Adaptive peripheral immune response increases proliferation of neural precursor cells in the adult hippocampus.
Wolf, S.A. ORCID: https://orcid.org/0000-0003-0922-8418, Steiner, B., Wengner, A.M. ORCID: https://orcid.org/0009-0009-5772-1945, Lipp, M. ORCID: https://orcid.org/0000-0002-0087-2672, Kammertoens, T. ORCID: https://orcid.org/0000-0003-3309-5141 and Kempermann, G. ORCID: https://orcid.org/0000-0002-5304-4061
FASEB Journal 23 (9): 3121-3128. September 2009

Folia Biologica Prague

Observations with tumour necrosis factor gene-transfected tumours.
Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Folia Biologica Prague 40 : 19-28. 1 January 1994

Frontiers in Cell and Developmental Biology

Editorial: Mitochondria as a hub in cellular signaling.
Stoolman, J.S., Porcelli, A.M. and Martínez-Reyes, I. ORCID: https://orcid.org/0000-0003-0479-1535
Frontiers in Cell and Developmental Biology 10 : 981464. 15 August 2022

Frontiers in Immunology

T cell receptors specific for an imatinib-induced mutation in BCR-ABL for adoptive T cell therapy.
Hsu, M.T. ORCID: https://orcid.org/0000-0002-5862-4305, Willimsky, G. ORCID: https://orcid.org/0000-0002-9693-948X, Hansmann, L. ORCID: https://orcid.org/0000-0003-3790-0128 and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Frontiers in Immunology 16 : 1518691. 27 January 2025

Generation of effective and specific human TCRs against tumor/testis antigen NY-ESO-1 in mice with humanized T cell recognition system.
Chen, X.T. ORCID: https://orcid.org/0000-0002-5614-1406, Leisegang, M. ORCID: https://orcid.org/0000-0003-3692-7142, Gavvovidis, I. ORCID: https://orcid.org/0000-0001-5644-9788, Pollack, S.M., Lorenz, F.K.M. ORCID: https://orcid.org/0000-0001-7826-0839, Schumacher, T.N., Daumke, O. ORCID: https://orcid.org/0000-0002-6190-1414 and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Frontiers in Immunology 15 : 1524629. 24 December 2024

Targeting the recurrent Rac1P29S neoepitope in melanoma with heterologous high-affinity T cell receptors.
Immisch, L., Papafotiou, G., Gallarín Delgado, N., Scheuplein, V., Paschen, A., Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321 and Willimsky, G. ORCID: https://orcid.org/0000-0002-9693-948X
Frontiers in Immunology 14 : 1119498. 16 February 2023

High salt inhibits tumor growth by enhancing anti-tumor immunity.
Willebrand, R., Hamad, I., Van Zeebroeck, L., Kiss, M., Bruderek, K., Geuzens, A., Swinnen, D., Côrte-Real, B.F., Markó, L. ORCID: https://orcid.org/0000-0003-1888-5575, Lebegge, E., Laoui, D., Kemna, J. ORCID: https://orcid.org/0000-0002-2172-4441, Kammertoens, T. ORCID: https://orcid.org/0000-0003-3309-5141, Brandau, S., Van Ginderachter, J.A. and Kleinewietfeld, M. ORCID: https://orcid.org/0000-0002-2832-3149
Frontiers in Immunology 10 : 1141. 4 June 2019

Interferon-γ receptor signaling in dendritic cells restrains spontaneous proliferation of CD4(+) T cells in chronic lymphopenic mice.
Knop, L., Frommer, C., Stoycheva, D., Deiser, K., Kalinke, U., Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321, Kammertoens, T. ORCID: https://orcid.org/0000-0003-3309-5141, Dunay, I.R. and Schüler, T.
Frontiers in Immunology 10 : 140. 7 February 2019

Gene Therapy

Allogeneic gene-modified tumor cells (RCC-26/IL-7/CD80) as a vaccine in patients with metastatic renal cell cancer: a clinical phase-I study.
Westermann, J., Floercken, A., Willimsky, G. ORCID: https://orcid.org/0000-0002-9693-948X, van Lessen, A., Kopp, J., Takvorian, A., Joehrens, K., Lukowsky, A., Schoenemann, C., Sawitzki, B., Pohla, H., Frank, R., Doerken, B. ORCID: https://orcid.org/0000-0001-7991-3643, Schendel, D.J., Blankenstein, T. and Pezzutto, A. ORCID: https://orcid.org/0000-0002-3246-4470
Gene Therapy 18 (4): 354-363. April 2011

In vivo splenic CD11c cells downregulate CD4 T-cell response thereby decreasing systemic immunity to gene-modified tumour cell vaccine.
Cayeux, S., Bukarica, B., Buschow, C., Charo, J. ORCID: https://orcid.org/0000-0002-5409-9160, Bunse, M. ORCID: https://orcid.org/0000-0002-7554-2520, Doerken, B. ORCID: https://orcid.org/0000-0001-7991-3643 and Blankenstein, T.
Gene Therapy 14 (20): 1481-1491. October 2007

Flt-3 ligand as adjuvant for DNA vaccination augments immune responses but does not skew TH1/TH2 polarization.
Westermann, J., Nguyen-Hoai, T., Mollweide, A., Richter, G., Schmetzer, O., Kim, H.J., Blankenstein, T., Doerken, B. ORCID: https://orcid.org/0000-0001-7991-3643 and Pezzutto, A. ORCID: https://orcid.org/0000-0002-3246-4470
Gene Therapy 11 (13): 1048-1056. 1 January 2004

Adenoviral transduction of tumor cells induces apoptosis in co-cultured T lymphocytes.
Scholz, C., Staerck, L., Willimsky, G. ORCID: https://orcid.org/0000-0002-9693-948X, Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321, Doerken, B. ORCID: https://orcid.org/0000-0001-7991-3643 and Daniel, P.T.
Gene Therapy 9 (21): 1438-1446. November 2002

Expression of B7.1 (CD80) in a renal cell carcinoma line allows expansion of tumor-associated cytotoxic T lymphocytes in the presence of an alloresponse.
Schendel, D.J., Frankenberger, B., Jantzer, P., Cayeux, S., Noessner, E., Willimsky, G. ORCID: https://orcid.org/0000-0002-9693-948X, Maget, B., Pohla, H. and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Gene Therapy 7 (23): 2007-2014. 1 December 2000

Retroviral interleukin-7 gene transfer into human dendritic cells enhances T cell activation.
Westermann, J., Aicher, A., Qin, Z., Cayeux, S., Daemen, K., Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321, Doerken, B. ORCID: https://orcid.org/0000-0001-7991-3643 and Pezzutto, A. ORCID: https://orcid.org/0000-0002-3246-4470
Gene Therapy 5 : 264-271. 1 January 1998

Loss of retroviral gene expression in bone marrow reconstituted mice correlates with down regulation of gene expression in long term culture initiating cells.
Lange, C. and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Gene Therapy 4 : 303-308. 1 January 1997

Cancer vaccines in gene therapy.
Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321 and Qin, Z.
Gene Therapy 3 (2): 95-96. 1 January 1996

Haematologica

A phase I study of MAGE-A1-targeted T1367 T-cell receptor-based cell therapy in patients with advanced multiple myeloma.
Krüger, J., Obenaus, M. ORCID: https://orcid.org/0000-0002-5090-9162, Blau, I.W., Hoser, D., Vaegler, M. ORCID: https://orcid.org/0009-0005-3852-4525, Rauschenbach, H., Anagnostopoulos, I., Jöhrens, K., Scheuplein, V., Kieback, E. ORCID: https://orcid.org/0000-0003-3831-2846, Böhme, J., Von Brünneck, A.C., Krönke, J., Busse, A. ORCID: https://orcid.org/0000-0002-3470-6947, Willimsky, G. ORCID: https://orcid.org/0000-0002-9693-948X, Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321, Pezzutto, A. ORCID: https://orcid.org/0000-0002-3246-4470, Keller, U. ORCID: https://orcid.org/0000-0002-8485-1958 and Nogai, A.
Haematologica 110 (1): 244-250. January 2025

HLA-C*04:09N is expressed at the cell surface and triggers peptide-specific T-cell activation.
Welters, C., Welters, M.L., Stadler, S., Bullinger, L. ORCID: https://orcid.org/0000-0002-5890-5510, Strobel, J., Hackstein, H., Dhamodaran, A. ORCID: https://orcid.org/0000-0001-7711-9593, Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321 and Hansmann, L. ORCID: https://orcid.org/0000-0003-3790-0128
Haematologica 109 (4): 1121-1127. April 2024

Human Gene Therapy

In remembrance of Professor Zelig Eshhar: a life committed to CAR-T.
Debets, Reno, Hawkins, Robert, Gilham, David, Gorochov, Guy, Schumacher, Ton, Uckert, Wolfgang, Blankenstein, Thomas ORCID: https://orcid.org/0000-0002-3357-4321, Crawford, Dorothy, Taylor, Naomi, Szöllösi, János, Stauss, Hans, Mondino, Anna, Allavena, Paola, Alarcón, Balbino, Büning, Hildegard and Abken, Hinrich
Human Gene Therapy 37 (1-2): 65-67. 1 January 2026

Efficient non-viral T cell engineering by Sleeping Beauty minicircles diminishing DNA toxicity and miRNAs silencing the endogenous TCR.
Clauss, J. ORCID: https://orcid.org/0000-0001-6783-1536, Obenaus, M. ORCID: https://orcid.org/0000-0002-5090-9162, Miskey, C. ORCID: https://orcid.org/0000-0002-7566-9556, Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Uckert, W. and Bunse, M. ORCID: https://orcid.org/0000-0002-7554-2520
Human Gene Therapy 29 (5): 569-584. May 2018

Phase I trial of an allogeneic gene-modified tumor cell vaccine (RCC-26/CD80/IL-2) in patients with metastatic renal cell carcinoma.
Buchner, A., Pohla, H., Willimsky, G. ORCID: https://orcid.org/0000-0002-9693-948X, Frankenberger, B., Frank, R., Baur-Melnyk, A., Siebels, M., Stief, C.G., Hofstetter, A., Kopp, J., Pezzutto, A. ORCID: https://orcid.org/0000-0002-3246-4470, Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321, Oberneder, R. and Schendel, D.J.
Human Gene Therapy 21 (3): 285-297. March 2010

Redirecting human T lymphocytes toward renal cell carcinoma specificity by retroviral transfer of T cell receptor genes.
Engels, B. ORCID: https://orcid.org/0000-0001-9682-2954, Noessner, E., Frankenberger, B., Blankenstein, T., Schendel, D.J. and Uckert, W.
Human Gene Therapy 16 (7): 799-810. 1 July 2005

Retroviral vectors for high-level transgene expression in T lymphocytes.
Engels, B. ORCID: https://orcid.org/0000-0001-9682-2954, Cam, H., Schueler, T., Indraccolo, S., Gladow, M., Baum, C., Blankenstein, T. and Uckert, W.
Human Gene Therapy 14 (12): 1155-1168. 10 August 2003

Efficient gene transfer into primary human CD8+ T lymphocytes by MuLV-10A1 retrovirus pseudotype.
Uckert, W., Becker, C., Gladow, M., Klein, D., Kammertoens, T. ORCID: https://orcid.org/0000-0003-3309-5141, Pedersen, L. and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Human Gene Therapy 11 (7): 1005-1014. 1 January 2000

Double suicide gene (cytosine deaminase and herpes simplex virus thymidine kinase) but not single gene transfer allows reliable elimination of tumor cells in vivo.
Uckert, W., Kammertoens, T. ORCID: https://orcid.org/0000-0003-3309-5141, Haack, K., Qin, Z., Gebert, J., Schendel, D.J. and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Human Gene Therapy 9 : 855-865. 1 January 1998

RNA levels of human retrovirus receptors Pit1 and Pit2 do not correlate with infectibility by three retroviral vector pseudotypes.
Uckert, W., Willimsky, G. ORCID: https://orcid.org/0000-0002-9693-948X, Pedersen, F.S., Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321 and Pedersen, L.
Human Gene Therapy 9 : 2619-2627. 1 January 1998

Strong immunogenic potential of a B7 retroviral expression vector: Generation of HLA-B7-restricted CTL response against selectable marker genes.
Jung, D., Jaeger, E., Cayeux, S., Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321, Hilmes, C., Karbach, J., Moebius, U., Knuth, A., Huber, C. and Seliger, B.
Human Gene Therapy 9 : 53-62. 1 January 1998

Transient expression of SV 40 large T antigen by Cre/LoxP mediated site specific deletion in primary human tumor cells.
Li, L.P., Schlag, P.M. and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Human Gene Therapy 8 : 1695-1700. 1 January 1997

Coexpression of interleukin-4 and B7.1 in murine tumor cells leads to improved tumor rejection and vaccine effect compared to single gene transfectants and a classical adjuvant.
Cayeux, S., Beck, C., Doerken, B. ORCID: https://orcid.org/0000-0001-7991-3643 and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Human Gene Therapy 7 (4): 525-529. 1 January 1996

The thymidine kinase/ganciclovir-mediated "suicide" effect is highly variable in different tumor cells.
Beck, C., Cayeux, S., Lupton, S., Doerken, B. ORCID: https://orcid.org/0000-0001-7991-3643 and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Human Gene Therapy 6 (12): 1525-1530. 1 January 1995

Immunity

Thymus-derived regulatory T cells are positively selected on natural self-antigen through cognate interactions of high functional avidity.
Kieback, E. ORCID: https://orcid.org/0000-0003-3831-2846, Hilgenberg, E., Stervbo, U. ORCID: https://orcid.org/0000-0002-2831-8868, Lampropoulou, V., Shen, P., Bunse, M. ORCID: https://orcid.org/0000-0002-7554-2520, Jaimes, Y., Boudinot, P., Radbruch, A., Klemm, U., Kühl, A.A., Liblau, R., Hoevelmeyer, N., Anderton, S.M., Uckert, W. and Fillatreau, S.
Immunity 44 (5): 1114-1126. 17 May 2016

CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions.
Ohl, L., Mohaupt, M., Czeloth, N., Hintzen, G., Kiafard, Z., Zwirner, J., Blankenstein, T., Henning, G. and Foerster, R.
Immunity 21 (2): 279-288. 1 August 2004

CD4+ T cell-mediated tumor rejection involves inhibition of angiogenesis that is dependent on IFNgamma receptor expression by nonhematopoietic cells.
Qin, Z.H. and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Immunity 12 (6): 677-686. 1 June 2000

Immunological Reviews

The adaptive immune response to sporadic cancer.
Willimsky, G. ORCID: https://orcid.org/0000-0002-9693-948X and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Immunological Reviews 220 (1): 102-112. December 2007

Immunology

Abnormal TNF production in prediabetic BB rats is linked to defective CD45R expression.
Rothe, H., Schuller, I., Richter, G., Jongeneel, C.V., Kiesel, U., Diamantstein, T., Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321 and Kolb, H.
Immunology 77 (1): 1-6. 1 January 1992

International Journal of Cancer

The immune system prevents recurrence of transplanted but not autochthonous antigenic tumors after oncogene inactivation therapy.
Anders, K. ORCID: https://orcid.org/0000-0002-0429-200X, Kershaw, O., Larue, L., Gruber, A.D. and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
International Journal of Cancer 141 (12): 2551-2561. 15 December 2017

Gene expression profiling of peripheral blood mononuclear cells during treatment with a gene-modified allogeneic tumor cell vaccine in advanced renal cell cancer: tumor-induced immunosuppression and a possible role for NF-κB.
Flörcken, A., Grau, M., Wolf, A., Weilemann, A., Kopp, J., Dörken, B. ORCID: https://orcid.org/0000-0001-7991-3643, Blankenstein, T., Pezzutto, A. ORCID: https://orcid.org/0000-0002-3246-4470, Lenz, P., Lenz, G. and Westermann, J.
International Journal of Cancer 136 (8): 1814-1826. 15 April 2015

Permissive expansion and homing of adoptively transferred T cells in tumor-bearing hosts.
Perez, C., Jukica, A., Listopad, J.J., Anders, K. ORCID: https://orcid.org/0000-0002-0429-200X, Kühl, A.A., Loddenkemper, C., Blankenstein, T. and Charo, J. ORCID: https://orcid.org/0000-0002-5409-9160
International Journal of Cancer 137 (2): 359-371. 15 July 2014

B-cells and IL-4 promote methylcholanthrene-induced carcinogenesis but there is no evidence for a role of T/NKT-cells and their effector molecules (Fas-ligand, TNF-α, perforin).
Kammertoens, T. ORCID: https://orcid.org/0000-0003-3309-5141, Qin, Z., Briesemeister, D., Bendelac, A. and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
International Journal of Cancer 131 (7): 1499-1508. 1 October 2012

Tumor rejection by local interferon gamma induction in established tumors is associated with blood vessel destruction and necrosis.
Briesemeister, D., Sommermeyer, D., Loddenkemper, C., Loew, R., Uckert, W., Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321 and Kammertoens, T. ORCID: https://orcid.org/0000-0003-3309-5141
International Journal of Cancer 128 (2): 371-378. 15 January 2011

SV40 large T antigen-transformed human primary normal and cancerous mammary epithelial cells are phenotypically similar but can be distinguished in 3D culture with selection medium.
Li, L.P., Willimsky, G. ORCID: https://orcid.org/0000-0002-9693-948X, Seitz, S., Xu, Y., Li, Y., Schwarz, L.E., Schlag, P.M. and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
International Journal of Cancer 123 (7): 1516-1525. 1 October 2008

Necrotic death but not irradiation abolishes costimulation of T-cell effector functions and survival by CD80-expressing tumor cells.
Staerck, L., Scholz, C., Blankenstein, T., Doerken, B. ORCID: https://orcid.org/0000-0001-7991-3643 and Daniel, P.T.
International Journal of Cancer 116 (1): 78-86. 1 January 2005

Tumor-induced antibodies resemble the response to tissue damage.
Preiss, S., Kammertoens, T. ORCID: https://orcid.org/0000-0003-3309-5141, Lampert, C., Willimsky, G. ORCID: https://orcid.org/0000-0002-9693-948X and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
International Journal of Cancer 115 (3): 456-462. 1 January 2005

CD4+ T cell-mediated HER-2/neu-specific tumor rejection in the absence of B cells.
Lindencrona, J.A., Preiss, S., Kammertoens, T. ORCID: https://orcid.org/0000-0003-3309-5141, Schueler, T., Piechocki, M., Wei, W.Z., Seliger, B., Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321 and Kiessling, R.
International Journal of Cancer 109 (2): 259-264. 1 January 2004

Conditional expression of human TNF-alpha: a system for inducible cytotoxicity.
Sparmann, G., Walther, W. ORCID: https://orcid.org/0000-0003-2884-0231, Guenzburg, W.H., Uckert, W. and Salmons, B.
International Journal of Cancer 59 : 103-107. 1 January 1994

International Journal of Oncology

Influence of retrovirally transduced human tumor-necrosis-factor-alpha on the expression of C-myc, k-ras, C-jun, p53, tgf-alpha, and cea in human colon-carcinoma cell-lines.
Uckert, W., Walther, W. ORCID: https://orcid.org/0000-0003-2884-0231 and Hummel, O.
International Journal of Oncology 6 : 1027-1031. 1 January 1995

Influence of different promoters on the expression of tumor necrosis factor alpha in LS174T human colon carcinoma cells.
Uckert, W., Asche, O., Mahanty, B. and Fichtner, I.
International Journal of Oncology 5 : 865-871. 1 January 1994

Journal for ImmunoTherapy of Cancer

Enhanced mutanome analysis towards the induction of neoepitope-reactive T-cell responses for personalized immunotherapy of pancreatic cancer.
Volkmar, M., Hoser, D., Lauenstein, C., Rebmann, J., Hotz-Wagenblatt, A., Rieger, J., Poschke, I. ORCID: https://orcid.org/0000-0002-4387-5566, Becker, J.P., Riemer, A.B., Sprick, M., Trumpp, A., Strobel, O., Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321, Willimsky, G. ORCID: https://orcid.org/0000-0002-9693-948X and Offringa, R. ORCID: https://orcid.org/0000-0001-6310-1026
Journal for ImmunoTherapy of Cancer 13 (6): e011802. June 2025

Selection of therapeutically effective T-cell receptors from the diverse tumor-bearing repertoire.
Rosenberger, L., Hansmann, L. ORCID: https://orcid.org/0000-0003-3790-0128, Anastasopoulou, V., Wolf, S.P. ORCID: https://orcid.org/0009-0008-2723-695X, Drousch, K., Moewes, C., Feng, X., Cao, G., Huang, J. ORCID: https://orcid.org/0000-0003-0271-4384, Yew, P.Y., Strønen, E. ORCID: https://orcid.org/0000-0001-9314-9389, Kato, T., Saligrama, N., Olweus, J., Nakamura, Y., Willimsky, G. ORCID: https://orcid.org/0000-0002-9693-948X, Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321, Schreiber, H. and Leisegang, M. ORCID: https://orcid.org/0000-0003-3692-7142
Journal for ImmunoTherapy of Cancer 13 (5): e011351. 2 May 2025

Response to: Correspondence on 'H3.3K27M mutation is not a suitable target for immunotherapy in HLA-A2+ patients with diffuse midline glioma' by Chheda et al.
Immisch, L. ORCID: https://orcid.org/0000-0001-5072-8583, Papafotiou, G., Popp, O. ORCID: https://orcid.org/0000-0001-6240-4666, Mertins, P. ORCID: https://orcid.org/0000-0002-2245-528X, Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321 and Willimsky, G. ORCID: https://orcid.org/0000-0002-9693-948X
Journal for ImmunoTherapy of Cancer 11 (3): e006784. 14 March 2023

Generation of TGFβR2(-1) neoantigen-specific HLA-DR4-restricted T cell receptors for cancer therapy.
Plewa, N. ORCID: https://orcid.org/0000-0002-5888-297X, Poncette, L. ORCID: https://orcid.org/0000-0001-8300-3968 and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Journal for ImmunoTherapy of Cancer 11 (2): e006001. February 2023

H3.3K27M mutation is not a suitable target for immunotherapy in HLA-A2(+) patients with diffuse midline glioma.
Immisch, L., Papafotiou, G., Popp, O. ORCID: https://orcid.org/0000-0001-6240-4666, Mertins, P. ORCID: https://orcid.org/0000-0002-2245-528X, Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321 and Willimsky, G. ORCID: https://orcid.org/0000-0002-9693-948X
Journal for ImmunoTherapy of Cancer 10 (10): e005535. 27 October 2022

Journal of Allergy and Clinical Immunology

Neuroimmune crosstalk in asthma: dual role of the neurotrophin receptor p75NTR.
Nassenstein, C., Kammertoens, T. ORCID: https://orcid.org/0000-0003-3309-5141, Veres, T.Z., Uckert, W., Spies, E., Fuchs, B., Krug, N. and Braun, A.
Journal of Allergy and Clinical Immunology 120 (5): 1089-1096. November 2007

Journal of Biological Chemistry

The role of toll-like receptors (TLRs) in bacteria-induced maturation of murine dendritic cells (DCS). Peptidoglycan and lipoteichoic acid are inducers of DC maturation and require TLR2.
Michelsen, K.S., Aicher, A., Mohaupt, M., Hartung, T., Dimmeler, S., Kirschning, C.J. and Schumann, R.R.
Journal of Biological Chemistry 276 (28): 25680-25686. 13 July 2001

Journal of Clinical Investigation

Effective NY-ESO-1-specific MHC II-restricted T cell receptors from antigen-negative hosts enhance tumor regression.
Poncette, L. ORCID: https://orcid.org/0000-0001-8300-3968, Chen, X. ORCID: https://orcid.org/0000-0002-5614-1406, Lorenz, F.K.M. ORCID: https://orcid.org/0000-0001-7826-0839 and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Journal of Clinical Investigation 129 (1): 324-335. 2 January 2019

Targeting human melanoma neoantigens by T cell receptor gene therapy.
Leisegang, M. ORCID: https://orcid.org/0000-0003-3692-7142, Kammertoens, T. ORCID: https://orcid.org/0000-0003-3309-5141, Uckert, W. and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Journal of Clinical Investigation 126 (3): 854-858. 1 March 2016

MHCII-independent CD4(+) T cells protect injured CNS neurons via IL-4.
Walsh, J.T., Hendrix, S., Boato, F., Smirnov, I., Zheng, J., Lukens, J.R., Gadani, S., Hechler, D., Gölz, G., Rosenberger, K., Kammertöns, T. ORCID: https://orcid.org/0000-0003-3309-5141, Vogt, J., Vogelaar, C., Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868, Radjavi, A., Fernandez-Castaneda, A., Gaultier, A., Gold, R., Kanneganti, T.D., Nitsch, R., Zipp, F. ORCID: https://orcid.org/0000-0002-1231-1928 and Kipnis, J.
Journal of Clinical Investigation 125 (2): 699-714. 2 February 2015

Virus-induced hepatocellular carcinomas cause antigen-specific local tolerance.
Willimsky, G. ORCID: https://orcid.org/0000-0002-9693-948X, Schmidt, K. ORCID: https://orcid.org/0000-0002-0572-6199, Loddenkemper, C., Gellermann, J. and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Journal of Clinical Investigation 123 (3): 1032-1043. 1 March 2013

Journal of Experimental Medicine

Human TCR-MHC coevolution after divergence from mice includes increased nontemplate-encoded CDR3 diversity.
Chen, X. ORCID: https://orcid.org/0000-0002-5614-1406, Poncette, L. ORCID: https://orcid.org/0000-0001-8300-3968 and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Journal of Experimental Medicine 214 (11): 3417-3433. 6 November 2017

Preventing tumor escape by targeting a post-proteasomal trimming independent epitope.
Textor, A., Schmidt, K. ORCID: https://orcid.org/0000-0002-0572-6199, Kloetzel, P.M., Weißbrich, B., Perez, C., Charo, J. ORCID: https://orcid.org/0000-0002-5409-9160, Anders, K. ORCID: https://orcid.org/0000-0002-0429-200X, Sidney, J., Sette, A., Schumacher, T.N.M., Keller, C., Busch, D.H., Seifert, U. and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Journal of Experimental Medicine 213 (11): 2333-2348. 17 October 2016

Immunogenicity of premalignant lesions is the primary cause of general cytotoxic T lymphocyte unresponsiveness.
Willimsky, G. ORCID: https://orcid.org/0000-0002-9693-948X, Czeh, M., Loddenkemper, C., Gellermann, J., Schmidt, K. ORCID: https://orcid.org/0000-0002-0572-6199, Wust, P., Stein, H. and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Journal of Experimental Medicine 205 (7): 1687-1700. 7 July 2008

Tumor rejection by modulation of tumor stromal fibroblasts.
Schueler, T., Koernig, S. and Blankenstein, T.
Journal of Experimental Medicine 198 (10): 1487-1493. 17 November 2003

Inhibition of methylcholanthrene-induced carcinogenesis by an interferon gamma receptor-dependent foreign body reaction.
Qin, Z., Kim, H.J., Hemme, J. and Blankenstein, T.
Journal of Experimental Medicine 195 (11): 1479-1490. 3 June 2002

Generation of tumor-associated cytotoxic T lymphocytes requires interleukin 4 from CD8+ T cells.
Schueler, T., Kammertoens, T. ORCID: https://orcid.org/0000-0003-3309-5141, Preiss, S., Debs, P., Noben-Trauth, N. and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Journal of Experimental Medicine 194 (12): 1767-1775. 17 December 2001

Tumor rejection by disturbing tumor stroma cell interactions.
Ibe, S., Qin, Z.H., Schueler, T., Preiss, S. and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Journal of Experimental Medicine 194 (11): 1549-1559. 3 December 2001

T helper cell type 1-associated and cytotoxic T lymphocyte-mediated tumor immunity is impaired in interleukin 4-deficient mice.
Schueler, T., Qin, Z., Ibe, S., Noben-Trauth, N. and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Journal of Experimental Medicine 189 (5): 803-810. 1 March 1999

Interleukin 4 gene-defective mice reconstituted with wild-type bone marrow fail to produce normal immunoglobulin E levels.
Lange, C., Schueler, T. and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Journal of Experimental Medicine 187 (9): 1487-1493. 4 May 1998

Expression of tumor necrosis factor by different tumor cell lines results either in tumor suppression or augmented metastasis.
Qin, Z., Krueger-Krasagakes, S., Kunzendorf, U., Hock, H., Diamantstein, T. and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Journal of Experimental Medicine 178 (1): 355-360. 1 July 1993

Journal of Gene Medicine

MLV-10A1 retrovirus pseudotype efficiently transduces primary human CD4+ T lymphocytes.
Gladow, M., Becker, C., Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321 and Uckert, W.
Journal of Gene Medicine 2 (6): 409-415. 1 January 2000

Journal of Immunology

In vivo imaging of an inducible oncogenic tumor antigen visualizes tumor progression and predicts CTL tolerance.
Buschow, C., Charo, J., Anders, K. ORCID: https://orcid.org/0000-0002-0429-200X, Loddenkemper, C., Jukica, A., Alsamah, W., Perez, C., Willimsky, G. ORCID: https://orcid.org/0000-0002-9693-948X and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Journal of Immunology 184 (6): 2930-2938. 15 March 2010

CD4-positive T lymphocytes provide a neuroimmunological link in the control of adult hippocampal neurogenesis.
Wolf, S.A. ORCID: https://orcid.org/0000-0003-0922-8418, Steiner, B., Akpinarli, A., Kammertoens, T. ORCID: https://orcid.org/0000-0003-3309-5141, Nassenstein, C., Braun, A., Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321 and Kempermann, G. ORCID: https://orcid.org/0000-0002-5304-4061
Journal of Immunology 182 (7): 3979-3984. 1 April 2009

Dual T cell receptor expressing CD8+ T cells with tumor- and self-specificity can inhibit tumor growth without causing severe autoimmunity.
Weinhold, M., Sommermeyer, D., Uckert, W. and Blankenstein, T.
Journal of Immunology 179 (8): 5534-5542. 15 October 2007

IL-10 controls ultraviolet-induced carcinogenesis in mice.
Loser, K., Apelt, J., Voskort, M., Mohaupt, M., Balkow, S., Schwarz, T., Grabbe, S. and Beissert, S.
Journal of Immunology 179 (1): 365-371. 1 July 2007

A synthetic peptide homologous to functional domain of human IL-10 down-regulates expression of MHC class I and transporter associated with antigen processing 1/2 in human melanoma cells.
Kurte, M., Lopez, M., Aguirre, A., Escobar, A., Aguillon, J.C., Charo, J. ORCID: https://orcid.org/0000-0002-5409-9160, Larsen, C.G., Kiessling, R. and Salazar-Onfray, F.
Journal of Immunology 173 (3): 1731-1737. 1 January 2004

Establishment of early lymphoid organ infrastructure in transplanted tumors mediated by local production of lymphotoxin alpha and in the combined absence of functional B and T cells.
Kim, H.J., Kammertoens, T. ORCID: https://orcid.org/0000-0003-3309-5141, Janke, M., Schmetzer, O., Qin, Z., Berek, C. and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Journal of Immunology 172 (7): 4037-4047. 1 January 2004

Long-term suppression of tumor growth by TNF requires a Stat1- and IFN regulatory factor 1-dependent IFN-γ pathway but not IL-12 or IL-18.
Wu, T.H., Pabin, C.N., Qin, Z.H., Blankenstein, T., Philip, M., Dignam, J., Schreiber, K. and Schreiber, H.
Journal of Immunology 172 (5): 3243-3251. 1 January 2004

Cutting edge: CD8+ effector T cells reject tumors by direct antigen recognition but indirect action on host cells.
Schueler, T. and Blankenstein, T.
Journal of Immunology 170 (9): 4427-4431. 1 May 2003

Osteoprotegerin, a crucial regulator of bone metabolism, also regulates B cell development and function.
Yun, T.J., Tallquist, M.D., Aicher, A., Rafferty, K.L., Marshall, A.J., Moon, J.J., Ewings, M.K., Mohaupt, M., Herring, S.W. and Clark, E.A.
Journal of Immunology 166 : 1482-1491. 1 January 2001

Constitutive IL-10 production accounts for the high NK sensitivity, low MHC class I expression, and poor transporter associated with antigen processing (TAP)-1/2 function in the prototype NK target YAC-11.
Petersson, M., Charo, J., Salazar-Onfray, F., Noffz, G., Mohaupt, M., Qin, Z.H., Klein, G., Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321 and Kiessling, R.
Journal of Immunology 161 : 2099-2105. 1 September 1998

Neutrophils but not eosinophils are involved in growth suppression of IL-4-secreting tumors.
Noffz, G., Qin, Z.H., Kopf, M. and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Journal of Immunology 160 : 345-350. 1 January 1998

Costimulatory signals through B7.1/CD28 prevent T cell apoptosis during target cell lysis.
Daniel, P.T., Kroidl, A., Cayeux, S., Bargou, R.C., Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321 and Doerken, B. ORCID: https://orcid.org/0000-0001-7991-3643
Journal of Immunology 159 (8): 3808-3815. 15 October 1997

Interleukin-10 prevents dendritic cell accumulation and vaccination with granulocyte- macrophage colony-stimulating factor gene-modified tumor cells.
Qin, Z., Noffz, G., Mohaupt, M. and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Journal of Immunology 159 (2): 770-776. 15 July 1997

Down regulation of the expression and function of the transporter associated with antigen processing in murine tumor cell lines expressing IL-10.
Salazar-Onfray, F., Charo, J. ORCID: https://orcid.org/0000-0002-5409-9160, Petersson, M., Freland, S., Noffz, G., Qin, Z.H., Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321, Ljunggren, H.G. and Kiessling, R.
Journal of Immunology 159 : 3195-3202. 1 January 1997

Influence of gene modified (IL 7, IL 4, and B7) tumor cell vaccines on tumor antigen presentation.
Cayeux, S., Richter, G., Noffz, G., Doerken, B. ORCID: https://orcid.org/0000-0001-7991-3643 and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Journal of Immunology 158 : 2834-2841. 1 January 1997

IL-10 converts mouse lymphoma cells to a CTL-resistant, nk-sensitive phenotype with low but peptide-inducible MHC class I expression.
Salazar-Onfray, F., Petersson, M., Franksson, L., Matsuda, M., Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321, Karre, K. and Kiessling, R.
Journal of Immunology 154 (12): 6291-6298. 1 January 1995

Kinetic analysis of cytokine gene expression in the livers of naive and immune mice infected with Listeria monocytogenes. The immediate early phase in innate resistance and acquired immunity.
Ehlers, S., Mielke, M.E., Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321 and Hahn, H.
Journal of Immunology 149 (9): 3016-3022. 1 November 1992

Journal of Immunotherapy

T cell homing to tumors detected by 3D-coordinated positron emission tomography and magnetic resonance imaging.
Agger, R., Petersen, M.S., Petersen, C.C., Hansen, S.B., Stodkilde-Jorgensen, H., Skands, U., Blankenstein, T., Andersen, T.E., Hulgaard, E.F., Jorgensen, J.T., Marqversen, J., Gundersen, H.J. and Hokland, M.E.
Journal of Immunotherapy 30 (1): 29-39. January 2007

Journal of Molecular Medicine

Apoptosis resistance, mitotic catastrophe, and loss of ploidy control in Burkitt lymphoma.
Chumduri, C., Gillissen, B., Richter, A., Richter, A., Milojkovic, A., Overkamp, T., Mueller, A., Pott, C. and Daniel, P.T.
Journal of Molecular Medicine 93 (5): 559-572. May 2015

Leukemia-associated genetic aberrations in mesenchymal stem cells of children with acute lymphoblastic leukemia.
Shalapour, S., Eckert, C., Seeger, K., Pfau, M., Prada, J., Henze, G., Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321 and Kammertoens, T. ORCID: https://orcid.org/0000-0003-3309-5141
Journal of Molecular Medicine 88 (3): 249-265. March 2010

Transduction efficiency of MLV but not of HIV-1 vectors is pseudotype dependent on human primary T lymphocytes.
Muehlebach, M.D., Schmitt, I., Steidl, S., Stitz, J., Schweizer, M., Blankenstein, T., Cichutek, K. and Uckert, W.
Journal of Molecular Medicine 81 (12): 801-810. December 2003

Naive CD8+ but not CD4+ T cells induce maturation of dendritic cells.
Schueler, T. and Blankenstein, T.
Journal of Molecular Medicine 80 (8): 533-541. August 2002

Suicide gene therapy for pediatric tumors.
Beltinger, C., Uckert, W. and Debatin, K.M.
Journal of Molecular Medicine 78 (11): 598-612. 1 January 2001

Journal of Translational Medicine

Vaccination with a plasmid DNA encoding HER-2/neu together with low doses of GM-CSF and IL-2 in patients with metastatic breast carcinoma: a pilot clinical trial.
Norell, H., Poschke, I., Charo, J. ORCID: https://orcid.org/0000-0002-5409-9160, Wei, W.Z., Erskine, C., Piechocki, M.P., Knutson, K.L., Bergh, J., Lidbrink, E. and Kiessling, R.
Journal of Translational Medicine 8 (1): 53. 7 June 2010

Leukemia

Intracellular expression of FLT3 in Purkinje cells: implications for adoptive T-cell therapies.
Çakmak-Görür, N. ORCID: https://orcid.org/0000-0001-7857-2461, Radke, J. ORCID: https://orcid.org/0000-0001-9860-2007, Rhein, S. ORCID: https://orcid.org/0000-0002-9445-2352, Schumann, E., Willimsky, G. ORCID: https://orcid.org/0000-0002-9693-948X, Heppner, F.L., Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321 and Pezzutto, A. ORCID: https://orcid.org/0000-0002-3246-4470
Leukemia 33 (4): 1039-1043. April 2019

Methods in Molecular Medicine

Methods for use of cytokine gene-modified tumor cells in immunotherapy of cancer.
Qin, Z. and Blankenstein, T.
Methods in Molecular Medicine 7 : 339-348. 1997

Molecular Medicine

High immune response rates and decreased frequencies of regulatory T cells in metastatic renal cell carcinoma patients after tumor cell vaccination.
Pohla, H., Buchner, A., Stadlbauer, B., Frankenberger, B., Stevanovic, S., Walter, S., Frank, R., Schwachula, T., Olek, S., Kopp, J., Willimsky, G. ORCID: https://orcid.org/0000-0002-9693-948X, Stief, C.G., Hofstetter, A., Pezzutto, A. ORCID: https://orcid.org/0000-0002-3246-4470, Blankenstein, T., Oberneder, R. and Schendel, D.J.
Molecular Medicine 18 : 1499-1508. 8 February 2013

Molecular Therapy

CAR T cells with enhanced sensitivity to B cell maturation antigen for the targeting of B cell non-Hodgkin's lymphoma and multiple myeloma.
Bluhm, J., Kieback, E. ORCID: https://orcid.org/0000-0003-3831-2846, Marino, S.F. ORCID: https://orcid.org/0000-0001-5696-9679, Oden, F., Westermann, J., Chmielewski, M., Abken, H., Uckert, W., Höpken, U.E. ORCID: https://orcid.org/0000-0002-0776-4893 and Rehm, A. ORCID: https://orcid.org/0000-0001-7490-1950
Molecular Therapy 26 (8): 1906-1920. 1 August 2018

Natural Immunity

Tumor-cell-targeted cytokine gene transfer in experimental models for cancer therapy.
Hock, H., Dorsch, M., Richter, G., Kunzendorf, U., Krueger-Krasagakes, S., Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321, Qin, Z.H. and Diamantstein, T.
Natural Immunity 13 : 85-92. 1 January 1994

Nature

Sporadic immunogenic tumours avoid destruction by inducing T-cell tolerance.
Willimsky, G. ORCID: https://orcid.org/0000-0002-9693-948X and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Nature 437 (7055): 141-146. 1 September 2005

Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein.
Brocke, S., Gijbels, K., Allegretta, M., Ferber, I., Piercy, C., Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321, Martin, R., Utz, U., Karin, N., Mitchell, D., Veromaa, T., Waisman, A., Gaur, A., Conlon, P., Ling, N., Fairchild, P.J., Wraith, D.C., Ogarra, A., Fathman, C.G. and Steinman, L.
Nature 379 (6563): 343-346. 1 January 1996

Nature Biotechnology

Receptor combinations hone T-cell therapy.
Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Nature Biotechnology 34 (4): 389-391. 7 April 2016

Identification of human T-cell receptors with optimal affinity to cancer antigens using antigen-negative humanized mice.
Obenaus, M. ORCID: https://orcid.org/0000-0002-5090-9162, Leitão, C., Leisegang, M. ORCID: https://orcid.org/0000-0003-3692-7142, Chen, X. ORCID: https://orcid.org/0000-0002-5614-1406, Gavvovidis, I. ORCID: https://orcid.org/0000-0001-5644-9788, van der Bruggen, P., Uckert, W., Schendel, D.J. and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Nature Biotechnology 33 (4): 402-407. April 2015

Nature Communications

Mice with a diverse human T cell receptor repertoire selected on multiple HLA class I molecules.
Dhamodaran, A. ORCID: https://orcid.org/0000-0001-7711-9593, Chen, X. ORCID: https://orcid.org/0000-0002-5614-1406, Fellmer, N., Agrawal, D., Danner, E., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803 and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Nature Communications 16 (1): 5432. 1 July 2025

Nature Immunology

A cancer immunosurveillance controversy.
Qin, Z.H. and Blankenstein, T.
Nature Immunology 5 (1): 3-4. 1 January 2004

Nature Medicine

High-throughput identification of antigen-specific TCRs by TCR gene capture.
Linnemann, C., Heemskerk, B., Kvistborg, P., Kluin, R.J.C., Bolotin, D.A., Chen, X. ORCID: https://orcid.org/0000-0002-5614-1406, Bresser, K., Nieuwland, M., Schotte, R., Michels, S., Gomez-Eerland, R., Jahn, L., Hombrink, P., Legrand, N., Shu, C.J., Mamedov, I.Z., Velds, A., Blank, C.U., Haanen, J.B.A.G., Turchaninova, M.A., Kerkhoven, R.M., Spits, H., Hadrup, S.R., Heemskerk, M.H.M., Blankenstein, T., Chudakov, D.M., Bendle, G.M. and Schumacher, T.N.M.
Nature Medicine 19 (11): 1534-1541. November 2013

Transgenic mice with a diverse human T cell antigen receptor repertoire.
Li, L.P., Lampert, J.C., Chen, X. ORCID: https://orcid.org/0000-0002-5614-1406, Leitao, C., Popovic, J., Mueller, W. and Blankenstein, T.
Nature Medicine 16 (9): 1029-1034. September 2010

Adoptive tumor therapy with T lymphocytes enriched through an IFN-gamma capture assay.
Becker, C., Pohla, H., Frankenberger, B., Schueler, T., Assenmacher, M., Schendel, D.J. and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Nature Medicine 7 (10): 1159-1162. 1 January 2001

B cells inhibit induction of T cell-dependent tumor immunity.
Qin, Z.H., Richter, G., Schueler, T., Ibe, S., Cao, X.T. and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Nature Medicine 4 : 627-630. 1 January 1998

Nature Protocols

Generation of transgenic mice with megabase-sized human yeast artificial chromosomes by yeast spheroplast-embryonic stem cell fusion.
Li, L. and Blankenstein, T.
Nature Protocols 8 (8): 1567-1582. August 2013

Nature Reviews Cancer

The determinants of tumour immunogenicity.
Blankenstein, T., Coulie, P.G., Gilboa, E. and Jaffee, E.M.
Nature Reviews Cancer 12 (4): 307-313. April 2012

Nucleic Acids Research

Recognition but no repair of abasic site in single-stranded DNA by human ribosomal uS3 protein residing within intact 40S subunit.
Grosheva, A.S., Zharkov, D.O., Stahl, J., Gopanenko, Al.V., Tupikin, A.E., Kabilov, M.R., Graifer, D.M. and Karpova, G.G.
Nucleic Acids Research 45 (7): 3833-3843. 20 April 2017

Positioning of subdomain IIId and apical loop of domain II of the hepatitis C IRES on the human 40S ribosome.
Babaylova, E., Graifer, D., Malygin, A., Stahl, J., Shatsky, I. and Karpova, G.
Nucleic Acids Research 37 (4): 1141-1151. March 2009

Rapid method of total RNA mini-preparation from eucaryotic cells.
Walther, W. ORCID: https://orcid.org/0000-0003-2884-0231, Stein, U. ORCID: https://orcid.org/0000-0001-7006-282X and Uckert, W.
Nucleic Acids Research 21 (7): 1682. 11 April 1993

OncoImmunology

Localization-associated immune phenotypes of clonally expanded tumor-infiltrating T cells and distribution of their target antigens in rectal cancer.
Penter, L. ORCID: https://orcid.org/0000-0002-9060-0207, Dietze, K., Ritter, J., Lammoglia Cobo, M.F. ORCID: https://orcid.org/0000-0002-0369-0364, Garmshausen, J., Aigner, F., Bullinger, L. ORCID: https://orcid.org/0000-0002-5890-5510, Hackstein, H., Wienzek-Lischka, S., Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321, Hummel, M., Dornmair, K. and Hansmann, L. ORCID: https://orcid.org/0000-0003-3790-0128
OncoImmunology 8 (6): e1586409. 24 March 2019

Oncogene

The immune response to sporadic colorectal cancer in a novel mouse model.
Czeh, M., Loddenkemper, C., Shalapour, S., Schoen, C., Robine, S., Goldscheid, E., Stein, H., Schueler, T., Willimsky, G. ORCID: https://orcid.org/0000-0002-9693-948X and Blankenstein, T.
Oncogene 29 (50): 6591-6602. 16 December 2010

Overexpression of NPM-ALK induces different types of malignant lymphomas in IL-9 transgenic mice.
Lange, K., Uckert, W., Blankenstein, T., Nadrowitz, R., Bittner, C., Renauld, J.C., van Snick, J., Feller, A.C. and Merz, H.
Oncogene 22 (4): 517-527. 30 January 2003

Oncotarget

Adoptive T-cell therapy to treat liver cancer: Is the liver microenvironment key?
Willimsky, G. ORCID: https://orcid.org/0000-0002-9693-948X, Protzer, U., Knolle, P. and Heikenwalder, M.
Oncotarget 4 (8): 1117-1118. August 2013

PLoS ONE

Stress hormones or general well-being are not altered in immune-deficient mice lacking either T- and B- lymphocytes or Interferon gamma signaling if kept under specific pathogen free housing conditions.
Jeuthe, S., Kemna, J. ORCID: https://orcid.org/0000-0002-2172-4441, Kemna, C.P., Zocholl, D., Klopfleisch, R., Palme, R. ORCID: https://orcid.org/0000-0001-9466-3662, Kirschbaum, C., Thoene-Reineke, C. and Kammertoens, T. ORCID: https://orcid.org/0000-0003-3309-5141
PLoS ONE 15 (9): e0239231. 30 September 2020

Interleukin-7 modulates anti-tumor CD8+ T cell responses via its action on host cells.
Deiser, K., Stoycheva, D., Bank, U., Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321 and Schüler, T.
PLoS ONE 11 (7): e0159690. 22 July 2016

A novel MCPH1 isoform complements the defective chromosome condensation of human MCPH1-deficient cells.
Gavvovidis, I. ORCID: https://orcid.org/0000-0001-5644-9788, Rost, I., Trimborn, M., Kaiser, F.J., Purps, J., Wiek, C., Hanenberg, H., Neitzel, H. and Schindler, D.
PLoS ONE 7 (8): e40387. 30 August 2012

Stromal interferon-γ signaling and cross-presentation are required to eliminate antigen-loss variants of B cell lymphomas in mice.
Gerbitz, A., Sukumar, M., Helm, F., Wilke, A., Friese, C., Fahrenwaldt, C., Lehmann, F.M., Loddenkemper, C., Kammertoens, T. ORCID: https://orcid.org/0000-0003-3309-5141, Mautner, J., Schmitt, C.A. ORCID: https://orcid.org/0000-0002-4731-2226, Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321 and Bornkamm, G.W.
PLoS ONE 7 (3): e34552. 30 March 2012

Pharmacological Research

Pharmacology & Therapeutics

Retrovirus-mediated gene transfer in cancer therapy.
Uckert, W. and Walther, W. ORCID: https://orcid.org/0000-0003-2884-0231
Pharmacology & Therapeutics 63 : 323-347. 1 January 1994

Proceedings of the National Academy of Sciences of the United States of America

Fas expression by tumor stroma is required for cancer eradication.
Listopad, J.J., Kammertoens, T. ORCID: https://orcid.org/0000-0003-3309-5141, Anders, K. ORCID: https://orcid.org/0000-0002-0429-200X, Silkenstedt, B., Willimsky, G. ORCID: https://orcid.org/0000-0002-9693-948X, Schmidt, K. ORCID: https://orcid.org/0000-0002-0572-6199, Kuehl, A.A., Loddenkemper, C. and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Proceedings of the National Academy of Sciences of the United States of America 110 (6): 2276-2281. 5 February 2013

Engineering antigen-specific primary human NK cells against HER-2 positive carcinomas.
Kruschinski, A., Moosmann, A., Poschke, I., Norell, H., Chmielewski, M., Seliger, B., Kiessling, R., Blankenstein, T., Abken, H. and Charo, J. ORCID: https://orcid.org/0000-0002-5409-9160
Proceedings of the National Academy of Sciences of the United States of America 105 (45): 17481-17486. 11 November 2008

A safeguard eliminates T cell receptor gene-modified autoreactive T cells after adoptive transfer.
Kieback, E. ORCID: https://orcid.org/0000-0003-3831-2846, Charo, J. ORCID: https://orcid.org/0000-0002-5409-9160, Sommermeyer, D., Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321 and Uckert, W.
Proceedings of the National Academy of Sciences of the United States of America 105 (2): 623-628. 15 January 2008

Herpes simplex virus thymidine kinase/ganciclovir-induced apoptosis involves ligand-independent death receptor aggregation and activation of caspases.
Beltinger, C., Fulda, S., Kammertoens, T. ORCID: https://orcid.org/0000-0003-3309-5141, Meyer, E., Uckert, W. and Debatin, K.M.
Proceedings of the National Academy of Sciences of the United States of America 96 : 8699-8704. 20 July 1999

Mechanisms of rejection induced by tumor cell-targeted gene transfer of interleukin 2, interleukin 4, interleukin 7, tumor necrosis factor, or interferon-gamma.
Hock, H., Dorsch, M., Kunzendorf, U., Qin, Z., Diamantstein, T. and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Proceedings of the National Academy of Sciences of the United States of America 90 (7): 2774-2778. 1 April 1993

Prostate

Induction of PSA-specific CTLs and anti-tumor immunity by a genetic prostate cancer vaccine.
Roos, A.K., Pavlenko, M., Charo, J. ORCID: https://orcid.org/0000-0002-5409-9160, Egevad, L. and Pisa, P.
Prostate 62 (3): 217-223. 1 January 2005

Recent Results in Cancer Research

Regulated gene expression after retroviral vector-mediated delivery of cancer-relevant therapeutic genes.
Guenzburg, W.H., Karle, P., Mrochen, S., Sparmann, G., Saller, R., Klein, D., Uckert, W. and Salmons, B.
Recent Results in Cancer Research 144 : 116-126. 1 January 1997

Reviews of Physiology Biochemistry and Pharmacology

Genetic approaches to cancer immunotherapy.
Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321, Cayeux, S. and Qin, Z.
Reviews of Physiology Biochemistry and Pharmacology 129 : 1-49. 1 January 1996

Russian Journal of Bioorganic Chemistry

Protein S3 fragments neighboring mRNA during elongation and termination of translation on the human ribosome.
Khairulina, Y.S., Molotkov, M.V., Bulygin, K.N., Graifer, D.M., Ven’yaminova, A.G., Frolova, L.Y., Stahl, J. and Karpova, G.G.
Russian Journal of Bioorganic Chemistry 34 (6): 691-697. November 2008

Science Advances

CD8(+) T cell-derived CD40L mediates noncanonical cytotoxicity in CD40-expressing cancer cells.
Schiele, P., Sada Japp, A. ORCID: https://orcid.org/0000-0001-8106-8987, Stark, R., Sattelberg, J.J., Nikolaou, C., Kornhuber, G., Abbasi, P., Ding, N., Rosnev, S., Meinke, S., Mühle, K., Loyal, L., Braun, J., Dingeldey, M., Durlanik, S., Matzmohr, N., Ponikwicka-Tyszko, D., Wolczynski, S., Rahman, N.A., Taniuchi, I., Schlickeiser, S., Giesecke-Thiel, C., Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321, Na, I.K. ORCID: https://orcid.org/0000-0001-9902-5424, Thiel, A. and Frentsch, M.
Science Advances 11 (21): eadr9331. 23 May 2025

Seminars in Cancer Biology

Do autochthonous tumors interfere with effector T cell responses?
Blankenstein, T.
Seminars in Cancer Biology 17 (4): 267-274. August 2007

Thyroid

Thyrotropin receptor-specific lymphocytes in adenovirus-TSHR-immunized native and human leukocyte antigen-DR3-transgenic mice and in Graves' disease patient blood.
Degen, H., Gavvovidis, I. ORCID: https://orcid.org/0000-0001-5644-9788, Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321, Uhland, K. and Ungerer, M.
Thyroid 31 (6): 950-963. June 2021

Tissue Antigens

Coordinate downregulation of multiple MHC class I antigen processing genes in chemical-induced murine tumor cell lines of distinct origin.
Seliger, B., Wollscheid, U., Momburg, F., Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321 and Huber, C.
Tissue Antigens 56 (4): 327-336. 1 October 2000

Transgenic Research

Depot formation of doxycycline impairs Tet-regulated gene expression in vivo.
Anders, K. ORCID: https://orcid.org/0000-0002-0429-200X, Buschow, C., Charo, J. ORCID: https://orcid.org/0000-0002-5409-9160 and Blankenstein, T.
Transgenic Research 21 (5): 1099-1107. October 2012

Trends in Immunology

Cross-priming versus cross-tolerance: are two signals enough?
Blankenstein, T. and Schueler, T.
Trends in Immunology 23 (4): 171-173. 1 April 2002

Trends in Molecular Medicine

Diverse effects of obesity on antitumor immunity and immunotherapy.
Dyck, L. ORCID: https://orcid.org/0000-0002-2548-9039 and Lynch, L.
Trends in Molecular Medicine 29 (2): 112-123. February 2023

Immunotherapy: target the stroma to hit the tumor.
Kammertoens, T. ORCID: https://orcid.org/0000-0003-3309-5141, Schueler, T. and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Trends in Molecular Medicine 11 (5): 225-231. 1 January 2005

Verhandlungen der Deutschen Gesellschaft fuer Pathologie

Die Ueberexpression von NPM-ALK in haematopoietischen Stammzellen induziert verschiedene maligne Non-Hodgkin-Lymphome in der IL-9 transgenen Maus [Overexpression of NPM-ALK induces different types of malignant lymphomas in IL-9 transgenic mice].
Merz, H., Lange, K., Nadrowitz, R., Uckert, W., Blankenstein, T. and Feller, A.C.
Verhandlungen der Deutschen Gesellschaft fuer Pathologie 87 : 224-231. 1 January 2003

Virology

Lentiviral vectors pseudotyped with envelope glycoproteins derived from gibbon ape leukemia virus and murine leukemia virus 10A1.
Stitz, J., Buchholz, C.J., Engelstaedter, M., Uckert, W., Bloemer, U., Schmitt, I. and Cichutek, K.
Virology 273 (1): 16-20. 1 January 2000

Modulation of moloney leukemia virus long terminal repeat transcriptionalactivity by the murine CD4 silencer in retroviral vectors.
Indraccolo, S., Minuzzo, S., Habeler, W., Zamarchi, R., Fregonese, A., Guenzburg, W.H., Salmons, B., Uckert, W., Chieco-Bianchi, L. and Amadori, A.
Virology 276 : 83-92. 1 January 2000

World Journal of Urology

Cell-based vaccines for renal cell carcinoma: genetically-engineered tumor cells and monocyte-derived dendritic cells.
Frankenberger, B., Regn, S., Geiger, C., Noessner, E., Falk, C.S., Pohla, H., Javorovic, M., Silberzahn, T., Wilde, S., Buchner, A., Siebels, M., Oberneder, R., Willimsky, G. ORCID: https://orcid.org/0000-0002-9693-948X, Pezzutto, A. ORCID: https://orcid.org/0000-0002-3246-4470, Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321 and Schendel, D.J.
World Journal of Urology 23 (3): 166-174. 5 July 2005

bioRxiv

eLife

In vitro proteasome processing of neo-splicetopes does not predict their presentation in vivo.
Willimsky, G. ORCID: https://orcid.org/0000-0002-9693-948X, Beier, C., Immisch, L., Papafotiou, G., Scheuplein-Schlosser, V., Goede, A., Holzhütter, H.G., Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321 and Kloetzel, P.M.
eLife 10 : e62019. 20 April 2021

This list was generated on Mon Jun 22 22:46:06 2026 UTC.