American Journal of Physiology Endocrinology and Metabolism
Intestinal retinol saturase is implicated in the development of obesity and epithelial homeostasis upon injury.
Kiefer, M.F. 
ORCID: https://orcid.org/0000-0002-6344-2856, Meng, Y., Yang, N., Vahrenbrink, M., Wulff, S., Li, C., Wowro, S.J., Petricek, K.M., Sommerfeld, M., Flores, R.E., Obermayer, B. ORCID: https://orcid.org/0000-0002-9116-630X, Piepelow, K., Klaus, S., Hartl, K. ORCID: https://orcid.org/0000-0002-2965-0512, Guillot, A., Tacke, F., Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761 and Schupp, M.
American Journal of Physiology Endocrinology and Metabolism 327
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August 2024
Analytical Chemistry
Deep learning-assisted peak curation for large-scale LC-MS metabolomics.
Gloaguen, Y. ORCID: https://orcid.org/0000-0003-0493-8592, Kirwan, J.A. ORCID: https://orcid.org/0000-0002-5423-1651 and Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632
Analytical Chemistry 94
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29 March 2022
Concepts and software package for efficient quality control in targeted metabolomics studies - MeTaQuaC.
Kuhring, M. ORCID: https://orcid.org/0000-0002-3287-0313, Eisenberger, A., Schmidt, V. ORCID: https://orcid.org/0000-0002-5851-1087, Kränkel, N., Leistner, D.M., Kirwan, J. ORCID: https://orcid.org/0000-0002-5423-1651 and Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632
Analytical Chemistry 92
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4 August 2020
BMC Bioinformatics
SigsPack, a package for cancer mutational signatures.
Schumann, F., Blanc, E. ORCID: https://orcid.org/0000-0002-4369-0254, Messerschmidt, C. ORCID: https://orcid.org/0000-0001-8632-656X, Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321, Busse, A. ORCID: https://orcid.org/0000-0002-3470-6947 and Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632
BMC Bioinformatics 20
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2 September 2019
BMC Cancer
Acquired resistance to DZNep-mediated apoptosis is associated with copy number gains of AHCY in a B-cell lymphoma model.
Akpa, C.A., Kleo, K., Oker, E., Tomaszewski, N., Messerschmidt, C. ORCID: https://orcid.org/0000-0001-8632-656X, López, C., Wagener, R., Oehl-Huber, K., Dettmer, K., Schoeler, A., Lenze, D., Oefner, P.J., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Siebert, R., Capper, D., Dimitrova, L. and Hummel, M.
BMC Cancer 20
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14 May 2020
BMC Medical Genomics
Identification and ranking of recurrent neo-epitopes in cancer.
Blanc, E. ORCID: https://orcid.org/0000-0002-4369-0254, Holtgrewe, M. ORCID: https://orcid.org/0000-0002-3051-1763, Dhamodaran, A. ORCID: https://orcid.org/0000-0001-7711-9593, Messerschmidt, C. ORCID: https://orcid.org/0000-0001-8632-656X, Willimsky, G. ORCID: https://orcid.org/0000-0002-9693-948X, Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321 and Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632
BMC Medical Genomics 12
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27 November 2019
BMC Medicine
Feasibility and outcome of reproducible clinical interpretation of high-dimensional molecular data: a comparison of two molecular tumor boards.
Rieke, D.T. ORCID: https://orcid.org/0000-0003-0027-7977, de Bortoli, T., Horak, P., Lamping, M., Benary, M. ORCID: https://orcid.org/0000-0002-3067-2030, Jelas, I., Rüter, G., Berger, J., Zettwitz, M., Kagelmann, N., Kind, A., Fabian, F., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Glimm, H., Brors, B., Stenzinger, A., Fröhling, S. and Keilholz, U.
BMC Medicine 20
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24 October 2022
Bioinformatics
Identifying cancer cells from calling single-nucleotide variants in scRNA-seq data.
Marot-Lassauzaie, V. ORCID: https://orcid.org/0000-0002-8362-9634, Beneyto-Calabuig, S., Obermayer, B. ORCID: https://orcid.org/0000-0002-9116-630X, Velten, L., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632 and Haghverdi, L. ORCID: https://orcid.org/0000-0001-9280-9170
Bioinformatics 40
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September 2024
preon: fast and accurate entity normalization for drug names and cancer types in precision oncology.
Ermshaus, A., Piechotta, M., Rüter, G., Keilholz, U., Leser, U. and Benary, M. ORCID: https://orcid.org/0000-0002-3067-2030
Bioinformatics 40
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March 2024
ClearCNV: CNV calling from NGS panel data in the presence of ambiguity and noise.
May, V., Koch, L., Fischer-Zirnsak, B. ORCID: https://orcid.org/0000-0002-1075-7571, Horn, D., Gehle, P., Kornak, U., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632 and Holtgrewe, M. ORCID: https://orcid.org/0000-0002-3051-1763
Bioinformatics 38
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15 August 2022
Digestiflow: from BCL to FASTQ with ease.
Holtgrewe, M. ORCID: https://orcid.org/0000-0002-3051-1763, Messerschmidt, C. ORCID: https://orcid.org/0000-0001-8632-656X, Nieminen, M. ORCID: https://orcid.org/0000-0002-4180-8810 and Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632
Bioinformatics 36
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15 March 2020
HLA-MA: simple yet powerful matching of samples using HLA typing results.
Messerschmidt, C. ORCID: https://orcid.org/0000-0001-8632-656X, Holtgrewe, M. ORCID: https://orcid.org/0000-0002-3051-1763 and Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632
Bioinformatics 33
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Biology of Sex Differences
Sex-specific molecular signature of mouse podocytes in homeostasis and in response to pharmacological challenge with rapamycin.
Al-Diab, O., Sünkel, C. ORCID: https://orcid.org/0000-0002-5326-6043, Blanc, E. ORCID: https://orcid.org/0000-0002-4369-0254, Catar, R.A., Ashraf, M.I., Zhao, H., Wang, P., Rinschen, M.M., Fritsche-Guenther, R. ORCID: https://orcid.org/0000-0002-6965-0226, Grahammer, F., Bachmann, S., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Kirwan, J.A. ORCID: https://orcid.org/0000-0002-5423-1651, Rajewsky, N. ORCID: https://orcid.org/0000-0002-4785-4332, Huber, T.B., Gürgen, D. ORCID: https://orcid.org/0000-0001-9241-6537 and Kusch, A. ORCID: https://orcid.org/0000-0002-6666-7081
Biology of Sex Differences 15
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15 September 2024
Brain Behavior and Immunity
Microglia undergo molecular and functional adaptations to dark and light phases in male laboratory mice.
Mattei, D. ORCID: https://orcid.org/0000-0001-6221-9321, Ivanov, A. ORCID: https://orcid.org/0000-0002-4824-1925, Hammer, J., Ugursu, B. ORCID: https://orcid.org/0000-0002-2488-4141, Schalbetter, S., Richetto, J., Weber-Stadlbauer, U., Mueller, F., Scarborough, J., Wolf, S.A. ORCID: https://orcid.org/0000-0003-0922-8418, Kettenmann, H. ORCID: https://orcid.org/0000-0001-8208-0291, Wollscheid, B., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632 and Meyer, U. ORCID: https://orcid.org/0000-0001-7244-0345
Brain Behavior and Immunity 210
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Cancer Immunology Research
Immune phenotypes and target antigens of clonally expanded bone marrow T cells in treatment-naïve multiple myeloma.
Welters, C. ORCID: https://orcid.org/0000-0002-3098-9003, Lammoglia Cobo, M.F. ORCID: https://orcid.org/0000-0002-0369-0364, Stein, C.A. ORCID: https://orcid.org/0000-0002-7892-8007, Hsu, M.T. ORCID: https://orcid.org/0000-0002-5862-4305, Ben Hamza, A. ORCID: https://orcid.org/0000-0003-3021-7406, Penter, L. ORCID: https://orcid.org/0000-0002-9060-0207, Chen, X. ORCID: https://orcid.org/0000-0002-5614-1406, Buccitelli, C. ORCID: https://orcid.org/0000-0001-5865-4961, Popp, O. ORCID: https://orcid.org/0000-0001-6240-4666, Mertins, P. ORCID: https://orcid.org/0000-0002-2245-528X, Dietze, K. ORCID: https://orcid.org/0000-0002-8329-8329, Bullinger, L. ORCID: https://orcid.org/0000-0002-5890-5510, Moosmann, A. ORCID: https://orcid.org/0000-0001-8044-5146, Blanc, E. ORCID: https://orcid.org/0000-0002-4369-0254, Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Gerbitz, A. ORCID: https://orcid.org/0000-0002-0105-2086, Strobel, J. ORCID: https://orcid.org/0000-0002-1117-0350, Hackstein, H. ORCID: https://orcid.org/0000-0001-9722-8180, Rahn, H.P. ORCID: https://orcid.org/0000-0002-5233-3937, Dornmair, K. ORCID: https://orcid.org/0000-0003-0342-5373, Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321 and Hansmann, L. ORCID: https://orcid.org/0000-0003-3790-0128
Cancer Immunology Research 10
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1 November 2022
Cancer Research
YAP and β-catenin cooperate to drive oncogenesis in basal breast cancer.
Quinn, H.M. ORCID: https://orcid.org/0000-0002-1336-5709, Vogel, R., Popp, O. ORCID: https://orcid.org/0000-0001-6240-4666, Mertins, P. ORCID: https://orcid.org/0000-0002-2245-528X, Lan, L., Messerschmidt, C. ORCID: https://orcid.org/0000-0001-8632-656X, Landshammer, A., Lisek, K. ORCID: https://orcid.org/0000-0002-2406-8830, Château-Joubert, S., Marangoni, E., Koren, E., Fuchs, Y. and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Cancer Research 81
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April 2021
Drug resistance mechanisms in colorectal cancer dissected with cell type-specific dynamic logic models.
Eduati, F., Doldan-Martelli, V., Klinger, B. ORCID: https://orcid.org/0000-0003-0242-1506, Cokelaer, T., Sieber, A., Kogera, F., Dorel, M. ORCID: https://orcid.org/0000-0002-1663-2075, Garnett, M.J., Blüthgen, N. ORCID: https://orcid.org/0000-0002-0171-7447 and Saez-Rodriguez, J.
Cancer Research 77
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15 June 2017
Cancers
Isolation of neoantigen-specific human T cell receptors from different human and murine repertoires.
Grunert, C. ORCID: https://orcid.org/0000-0001-8376-8629, Willimsky, G. ORCID: https://orcid.org/0000-0002-9693-948X, Peuker, C.A. ORCID: https://orcid.org/0000-0002-0957-2166, Rhein, S. ORCID: https://orcid.org/0000-0002-9445-2352, Hansmann, L. ORCID: https://orcid.org/0000-0003-3790-0128, Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321, Blanc, E. ORCID: https://orcid.org/0000-0002-4369-0254, Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Keller, U. ORCID: https://orcid.org/0000-0002-8485-1958, Pezzutto, A. ORCID: https://orcid.org/0000-0002-3246-4470 and Busse, A. ORCID: https://orcid.org/0000-0002-3470-6947
Cancers 14
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6 April 2022
Progression-dependent altered metabolism in osteosarcoma resulting in different nutrient source dependencies.
Fritsche-Guenther, R. ORCID: https://orcid.org/0000-0002-6965-0226, Gloaguen, Y. ORCID: https://orcid.org/0000-0003-0493-8592, Kirchner, M. ORCID: https://orcid.org/0000-0002-7049-534X, Mertins, P. ORCID: https://orcid.org/0000-0002-2245-528X, Tunn, P.U. and Kirwan, J.A. ORCID: https://orcid.org/0000-0002-5423-1651
Cancers 12
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Cardiovascular Research
Prdm16 mutation determines sex-specific cardiac metabolism and identifies two novel cardiac metabolic regulators.
Kühnisch, J. ORCID: https://orcid.org/0000-0003-4744-5421, Theisen, S., Dartsch, J. ORCID: https://orcid.org/0000-0002-7947-2881, Fritsche-Guenther, R. ORCID: https://orcid.org/0000-0002-6965-0226, Kirchner, M. ORCID: https://orcid.org/0000-0002-7049-534X, Obermayer, B. ORCID: https://orcid.org/0000-0002-9116-630X, Bauer, A., Kahlert, A.K., Rothe, M. ORCID: https://orcid.org/0000-0002-6813-4705, Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Heuser, A. ORCID: https://orcid.org/0000-0002-3334-960X, Mertins, P. ORCID: https://orcid.org/0000-0002-2245-528X, Kirwan, J.A. ORCID: https://orcid.org/0000-0002-5423-1651, Berndt, N., MacRae, C.A., Hubner, N. ORCID: https://orcid.org/0000-0002-1218-6223 and Klaassen, S. ORCID: https://orcid.org/0000-0001-5925-9912
Cardiovascular Research 119
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Cell
Complement activation induces excessive T cell cytotoxicity in severe COVID-19.
Georg, P., Astaburuaga-García, R., Bonaguro, L., Brumhard, S., Michalick, L., Lippert, L.J., Kostevc, T., Gäbel, C., Schneider, M., Streitz, M., Demichev, V., Gemünd, I., Barone, M., Tober-Lau, P., Helbig, E.T., Hillus, D., Petrov, L., Stein, J., Dey, H.P., Paclik, D., Iwert, C., Mülleder, M., Aulakh, S.K., Djudjaj, S., Bülow, R.D., Mei, H.E., Schulz, A.R., Thiel, A., Hippenstiel, S., Saliba, A.E., Eils, R., Lehmann, I., Mall, M.A., Stricker, S., Röhmel, J., Corman, V.M., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Obermayer, B. ORCID: https://orcid.org/0000-0002-9116-630X, von Stillfried, S., Boor, P., Demir, M., Wesselmann, H., Suttorp, N., Uhrig, A., Müller-Redetzky, H., Nattermann, J., Kuebler, W.M., Meisel, C., Ralser, M., Schultze, J.L., Aschenbrenner, A.C., Thibeault, C., Kurth, F., Sander, L.E., Blüthgen, N. and Sawitzki, B.
Cell 185
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3 February 2022
Cell Chemical Biology
The anti-amyloid compound DO1 decreases plaque pathology and neuroinflammation-related expression changes in 5xFAD transgenic mice.
Boeddrich, A. ORCID: https://orcid.org/0000-0001-9118-050X, Babila, J.T., Wiglenda, T. ORCID: https://orcid.org/0000-0002-8460-9459, Diez, L. ORCID: https://orcid.org/0000-0003-3101-0191, Jacob, M., Nietfeld, W., Huska, M.R. ORCID: https://orcid.org/0000-0002-0912-745X, Haenig, C. ORCID: https://orcid.org/0000-0003-1973-7646, Groenke, N. ORCID: https://orcid.org/0000-0002-6927-3774, Buntru, A., Blanc, E. ORCID: https://orcid.org/0000-0002-4369-0254, Meier, J.C. ORCID: https://orcid.org/0000-0001-5574-3336, Vannoni, E., Erck, C., Friedrich, B., Martens, H., Neuendorf, N., Schnoegl, S., Wolfer, D.P., Loos, M., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Andrade-Navarro, M.A. and Wanker, E.E. ORCID: https://orcid.org/0000-0001-8072-1630
Cell Chemical Biology 26
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17 January 2019
Cell Death & Disease
Time‑resolved multi-omic analysis of paclitaxel exposure in human iPSC‑derived sensory neurons unveils mechanisms of chemotherapy‑induced peripheral neuropathy.
Schinke, Christian ORCID: https://orcid.org/0000-0003-0199-9672, Maierhof, Smilla K., Hew, Lois ORCID: https://orcid.org/0000-0002-0183-8177, Fernandez Vallone, Valeria, Frahm, Silke ORCID: https://orcid.org/0000-0001-5645-2557, Telugu, Narasimha Swamy ORCID: https://orcid.org/0000-0003-4509-7056, Diecke, Sebastian ORCID: https://orcid.org/0000-0002-5219-5992, Ivanov, Andranik ORCID: https://orcid.org/0000-0002-4824-1925, Kovács, Richard, Beule, Dieter ORCID: https://orcid.org/0000-0002-3284-0632, Kirchner, Marieluise ORCID: https://orcid.org/0000-0002-7049-534X, Mertins, Philipp ORCID: https://orcid.org/0000-0002-2245-528X, Brüning, Ulrike ORCID: https://orcid.org/0000-0003-0112-4032, Kirwan, Jennifer A. ORCID: https://orcid.org/0000-0002-5423-1651, Stachelscheid, Harald ORCID: https://orcid.org/0000-0002-9283-4605, Endres, Matthias ORCID: https://orcid.org/0000-0001-6520-3720, Huehnchen, Petra ORCID: https://orcid.org/0000-0002-6825-7270 and Boehmerle, Wolfgang ORCID: https://orcid.org/0000-0001-7195-3894
Cell Death & Disease 17
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19 February 2026
Cell Genomics
Mutational topography reflects clinical neuroblastoma heterogeneity.
Rodriguez-Fos, E. ORCID: https://orcid.org/0000-0002-2555-0178, Planas-Fèlix, M., Burkert, M. ORCID: https://orcid.org/0000-0002-6721-9985, Puiggròs, M., Toedling, J. ORCID: https://orcid.org/0000-0003-1471-1295, Thiessen, N., Blanc, E. ORCID: https://orcid.org/0000-0002-4369-0254, Szymansky, A. ORCID: https://orcid.org/0000-0003-4797-4526, Hertwig, F. ORCID: https://orcid.org/0000-0003-4784-6516, Ishaque, N. ORCID: https://orcid.org/0000-0002-8426-901X, Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Torrents, D., Eggert, A., Koche, R.P., Schwarz, R.F. ORCID: https://orcid.org/0000-0001-9155-4268, Haase, K. ORCID: https://orcid.org/0000-0002-0944-5618, Schulte, J.H. ORCID: https://orcid.org/0000-0003-0671-1201 and Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X
Cell Genomics 3
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11 October 2023
Cell Reports
let-7 microRNAs regulate microglial function and suppress glioma growth through Toll-like receptor 7.
Buonfiglioli, A. ORCID: https://orcid.org/0000-0002-5550-9360, Efe, I.E., Guneykaya, D., Ivanov, A. ORCID: https://orcid.org/0000-0002-4824-1925, Huang, Y. ORCID: https://orcid.org/0000-0001-9600-1195, Orlowski, E., Krüger, C., Deisz, R.A., Markovic, D., Flüh, C., Newman, A.G. ORCID: https://orcid.org/0000-0002-0222-9162, Schneider, U.C., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Wolf, S.A. ORCID: https://orcid.org/0000-0003-0922-8418, Dzaye, O., Gutmann, D.H. ORCID: https://orcid.org/0000-0002-3127-5045, Semtner, M. ORCID: https://orcid.org/0000-0001-9379-9023, Kettenmann, H. ORCID: https://orcid.org/0000-0001-8208-0291 and Lehnardt, S.
Cell Reports 29
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10 December 2019
Transcriptional and translational differences of microglia from male and female brains.
Guneykaya, D. ORCID: https://orcid.org/0000-0001-5723-0737, Ivanov, A. ORCID: https://orcid.org/0000-0002-4824-1925, Perez Hernandez, D. ORCID: https://orcid.org/0000-0003-0266-9050, Haage, V. ORCID: https://orcid.org/0000-0001-7569-8421, Wojtas, B., Meyer, N. ORCID: https://orcid.org/0000-0002-8377-097X, Maricos, M. ORCID: https://orcid.org/0000-0002-3873-6887, Jordan, P., Buonfiglioli, A. ORCID: https://orcid.org/0000-0002-5550-9360, Gielniewski, B., Ochocka, N., Cömert, C., Friedrich, C. ORCID: https://orcid.org/0000-0002-5586-1989, Suarez Artiles, L. ORCID: https://orcid.org/0000-0001-7991-5446, Kaminska, B., Mertins, P. ORCID: https://orcid.org/0000-0002-2245-528X, Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Kettenmann, H. ORCID: https://orcid.org/0000-0001-8208-0291 and Wolf, S.A. ORCID: https://orcid.org/0000-0003-0922-8418
Cell Reports 24
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4 September 2018
Cellular Oncology
Robust detection of clinically relevant features in single-cell RNA profiles of patient-matched fresh and formalin-fixed paraffin-embedded (FFPE) lung cancer tissue.
Trinks, A. ORCID: https://orcid.org/0000-0001-9983-1506, Milek, M. ORCID: https://orcid.org/0000-0002-0803-8439, Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Kluge, J., Florian, S. ORCID: https://orcid.org/0000-0002-0193-1320, Sers, C. ORCID: https://orcid.org/0000-0002-6219-1514, Horst, D. ORCID: https://orcid.org/0000-0003-4755-5743, Morkel, M. ORCID: https://orcid.org/0000-0002-2553-9999 and Bischoff, P. ORCID: https://orcid.org/0000-0002-4442-7116
Cellular Oncology 47
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Circulation
Heart-specific immune responses in an animal model of autoimmune-related myocarditis mitigated by an immunoproteasome inhibitor and genetic ablation.
Bockstahler, M., Fischer, A., Goetzke, C.C., Neumaier, H.L., Sauter, M., Kespohl, M., Müller, A.M., Meckes, C., Salbach, C., Schenk, M., Heuser, A. ORCID: https://orcid.org/0000-0002-3334-960X, Landmesser, U., Weiner, J. ORCID: https://orcid.org/0000-0003-1438-7819, Meder, B., Lehmann, L., Kratzer, A., Klingel, K., Katus, H.A., Kaya, Z. and Beling, A.
Circulation 141
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9 June 2020
Circulation Genomic and Precision Medicine
Pathogenic variants associated with dilated cardiomyopathy predict outcome in pediatric myocarditis.
Seidel, F. ORCID: https://orcid.org/0000-0002-1328-1580, Holtgrewe, M. ORCID: https://orcid.org/0000-0002-3051-1763, Al-Wakeel-Marquard, N., Opgen-Rhein, B. ORCID: https://orcid.org/0000-0002-4535-4529, Dartsch, J. ORCID: https://orcid.org/0000-0002-7947-2881, Herbst, C. ORCID: https://orcid.org/0000-0003-2044-5181, Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Pickardt, T. ORCID: https://orcid.org/0000-0003-0019-6325, Klingel, K. ORCID: https://orcid.org/0000-0003-0203-2498, Messroghli, D. ORCID: https://orcid.org/0000-0003-1331-5004, Berger, F. ORCID: https://orcid.org/0000-0001-7881-1557, Schubert, S. ORCID: https://orcid.org/0000-0003-2894-6490, Kühnisch, J. ORCID: https://orcid.org/0000-0003-4744-5421 and Klaassen, S. ORCID: https://orcid.org/0000-0001-5925-9912
Circulation Genomic and Precision Medicine 14
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4 August 2021
Clinical Genetics
GLI3 variants causing isolated polysyndactyly are not restricted to the protein's C-terminal third.
Sczakiel, H.L., Hülsemann, W., Holtgrewe, M. ORCID: https://orcid.org/0000-0002-3051-1763, Abad-Perez, A.T., Elsner, J., Schwartzmann, S., Horn, D., Spielmann, M., Mundlos, S. and Mensah, M.A. ORCID: https://orcid.org/0000-0001-8080-8779
Clinical Genetics 100
(6): 758-765.
December 2021
Targeted panel sequencing in pediatric primary cardiomyopathy supports a critical role of TNNI3.
Kühnisch, J. ORCID: https://orcid.org/0000-0003-4744-5421, Herbst, C. ORCID: https://orcid.org/0000-0003-2044-5181, Al-Wakeel-Marquard, N., Dartsch, J. ORCID: https://orcid.org/0000-0002-7947-2881, Holtgrewe, M. ORCID: https://orcid.org/0000-0002-3051-1763, Baban, A., Mearini, G., Hardt, J., Kolokotronis, K., Gerull, B. ORCID: https://orcid.org/0000-0002-1363-8826, Carrier, L. ORCID: https://orcid.org/0000-0001-8776-5820, Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Schubert, S., Messroghli, D. ORCID: https://orcid.org/0000-0003-1331-5004, Degener, F., Berger, F. ORCID: https://orcid.org/0000-0001-7881-1557 and Klaassen, S. ORCID: https://orcid.org/0000-0001-5925-9912
Clinical Genetics 96
(6): 549-559.
December 2019
Clinical Nutrition
Thrifty energy phenotype predicts weight regain in postmenopausal women with overweight or obesity and is related to FGFR1 signaling.
Spranger, L., Weiner, J. ORCID: https://orcid.org/0000-0003-1438-7819, Bredow, J., Zeitz, U., Grittner, U., Boschmann, M. ORCID: https://orcid.org/0000-0002-0114-7114, Dickmann, S., Stobäus, N., Schwartzenberg, R.J., Brachs, M., Spranger, J. ORCID: https://orcid.org/0000-0002-8900-4467 and Mai, K.
Clinical Nutrition 42
(4): 559-567.
April 2023
Communications Biology
Diverse but unique astrocytic phenotypes during embryonic stem cell differentiation, culturing and development.
Freitag, K. ORCID: https://orcid.org/0000-0002-5244-3140, Eede, P., Ivanov, A. ORCID: https://orcid.org/0000-0002-4824-1925, Sterczyk, N., Schneeberger, S., Borodina, T. ORCID: https://orcid.org/0000-0002-6978-016X, Sauer, S. ORCID: https://orcid.org/0000-0002-4794-3693, Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632 and Heppner, F.L. ORCID: https://orcid.org/0000-0001-9816-8917
Communications Biology 6
(1): 40.
13 January 2023
Human alveolar progenitors generate dual lineage bronchioalveolar organoids.
Hoffmann, K., Obermayer, B. ORCID: https://orcid.org/0000-0002-9116-630X, Hönzke, K., Fatykhova, D., Demir, Z. ORCID: https://orcid.org/0000-0001-5329-5517, Löwa, A., Teixeira Alves, L.G. ORCID: https://orcid.org/0000-0002-5822-4168, Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Lopez-Rodriguez, E., Mieth, M., Baumgardt, M., Hoppe, J., Firsching, T.C. ORCID: https://orcid.org/0000-0003-1378-4951, Tönnies, M., Bauer, T.T., Eggeling, S., Tran, H.L., Schneider, P., Neudecker, J., Rückert, J.C., Gruber, A.D. ORCID: https://orcid.org/0000-0002-4502-0393, Ochs, M. ORCID: https://orcid.org/0000-0002-0936-6979, Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Suttorp, N., Hippenstiel, S., Hocke, A.C. and Kessler, M. ORCID: https://orcid.org/0000-0002-9879-1052
Communications Biology 5
(1): 875.
25 August 2022
Integrated multi-omics analysis of RB-loss identifies widespread cellular programming and synthetic weaknesses.
Rajasekaran, S. ORCID: https://orcid.org/0000-0002-1271-6204, Siddiqui, J., Rakijas, J., Nicolay, B., Lin, C., Khan, E., Patel, R., Morris, R., Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Boukhali, M., Balasubramanyam, J., Ranjith Kumar, R., Van Rechem, C. ORCID: https://orcid.org/0000-0002-5408-6124, Vogel, C., Elchuri, S.V., Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Obermayer, B. ORCID: https://orcid.org/0000-0002-9116-630X, Haas, W., Dyson, N. and Miles, W. ORCID: https://orcid.org/0000-0002-2054-5206
Communications Biology 4
(1): 977.
17 August 2021
Data in Brief
Dataset for: Modeling chemotherapy induced neurotoxicity with human induced pluripotent stem cell (iPSC)-derived sensory neurons.
Schinke, C., Fernandez Vallone, V. ORCID: https://orcid.org/0000-0003-3875-9170, Ivanov, A. ORCID: https://orcid.org/0000-0002-4824-1925, Peng, Y. ORCID: https://orcid.org/0000-0002-0317-1353, Körtvelyessy, P., Nolte, L. ORCID: https://orcid.org/0000-0002-9092-9627, Huehnchen, P., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Stachelscheid, H. ORCID: https://orcid.org/0000-0002-9283-4605, Boehmerle, W. ORCID: https://orcid.org/0000-0001-7195-3894 and Endres, M. ORCID: https://orcid.org/0000-0001-6520-3720
Elsevier.
October 2021
EClinicalMedicine
Highly multiplexed immune repertoire sequencing links multiple lymphocyte classes with severity of response to COVID-19.
Dannebaum, R., Suwalski, P. ORCID: https://orcid.org/0000-0002-2678-2595, Asgharian, H., Du Zhipei, G. ORCID: https://orcid.org/0000-0002-8230-4686, Lin, H., Weiner, J. ORCID: https://orcid.org/0000-0003-1438-7819, Holtgrewe, M. ORCID: https://orcid.org/0000-0002-3051-1763, Thibeault, C., Müller, M., Wang, X., Karadeniz, Z., Saccomanno, J., Doehn, J.M., Hübner, R.H., Hinzmann, B., Blüher, A., Siemann, S., Telman, D., Suttorp, N., Witzenrath, M., Hippenstiel, S., Skurk, C., Poller, W., Sander, L.E., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Kurth, F., Guettouche, T., Landmesser, U., Berka, J., Luong, K., Rubelt, F. and Heidecker, B.
EClinicalMedicine 48
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June 2022
Increased risk of severe clinical course of COVID-19 in carriers of HLA-C*04:01.
Weiner, J. ORCID: https://orcid.org/0000-0003-1438-7819, Suwalski, P., Holtgrewe, M. ORCID: https://orcid.org/0000-0002-3051-1763, Rakitko, A. ORCID: https://orcid.org/0000-0003-0567-7734, Thibeault, C., Müller, M., Patriki, D., Quedenau, C. ORCID: https://orcid.org/0000-0002-6846-4915, Krüger, U., Ilinsky, V. ORCID: https://orcid.org/0000-0003-4377-2759, Popov, I., Balnis, J., Jaitovich, A., Helbig, E.T., Lippert, L.J., Stubbemann, P., Real, L.M., Macías, J., Pineda, J.A., Fernandez-Fuertes, M., Wang, X., Karadeniz, Z., Saccomanno, J., Doehn, J.M., Hübner, R.H., Hinzmann, B., Salvo, M., Blueher, A., Siemann, S., Jurisic, S., Beer, J.H., Rutishauser, J., Wiggli, B., Schmid, H., Danninger, K., Binder, R., Corman, V.M., Mühlemann, B., Arjun Arkal, R., Fragiadakis, G.K., Mick, E. ORCID: https://orcid.org/0000-0002-7299-808X, Calfee, C.S., Erle, D.J., Hendrickson, C.M., Kangelaris, K.N., Krummel, M.F., Woodruff, P.G., Langelier, C.R., Venkataramani, U., García, F., Zyla, J. ORCID: https://orcid.org/0000-0002-2895-7969, Drosten, C., Braun, A. ORCID: https://orcid.org/0000-0003-1145-0261, Jones, T.C., Suttorp, N., Witzenrath, M., Hippenstiel, S., Zemojtel, T., Skurk, C., Wolfgang, P., Borodina, T. ORCID: https://orcid.org/0000-0002-6978-016X, Ripke, S., Sander, L.E., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Landmesser, U., Guettouche, T., Kurth, F. and Heidecker, B.
EClinicalMedicine 40
: 101099.
October 2021
EMBO Molecular Medicine
Disrupting TSLP-TSLP receptor interactions via putative small molecule inhibitors yields a novel and efficient treatment option for atopic diseases.
Adhikary, P.P. ORCID: https://orcid.org/0000-0002-3755-0810, Idowu, T. ORCID: https://orcid.org/0000-0003-1583-8562, Tan, Z., Hoang, C., Shanta, S., Dumbani, M., Mappalakayil, L. ORCID: https://orcid.org/0009-0009-7418-1215, Awasthi, B. ORCID: https://orcid.org/0000-0002-2636-510X, Bermudez, M. ORCID: https://orcid.org/0000-0002-7421-3282, Weiner, J. ORCID: https://orcid.org/0000-0003-1438-7819, Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Wolber, G., Page, B.D. ORCID: https://orcid.org/0000-0002-2101-1329 and Hedtrich, S. ORCID: https://orcid.org/0000-0001-6770-3657
EMBO Molecular Medicine 16
(7): 1630-1656.
15 July 2024
Mitogen-activated protein kinase activity drives cell trajectories in colorectal cancer.
Uhlitz, F. ORCID: https://orcid.org/0000-0001-9176-4660, Bischoff, P. ORCID: https://orcid.org/0000-0002-4442-7116, Peidli, S. ORCID: https://orcid.org/0000-0002-4257-8690, Sieber, A., Trinks, A. ORCID: https://orcid.org/0000-0001-9983-1506, Lüthen, M. ORCID: https://orcid.org/0000-0001-5557-6419, Obermayer, B. ORCID: https://orcid.org/0000-0002-9116-630X, Blanc, E. ORCID: https://orcid.org/0000-0002-4369-0254, Ruchiy, Y., Sell, T. ORCID: https://orcid.org/0000-0002-5138-3967, Mamlouk, S. ORCID: https://orcid.org/0000-0001-7285-1320, Arsie, R. ORCID: https://orcid.org/0000-0002-7869-7624, Wei, T.T. ORCID: https://orcid.org/0000-0001-5719-721X, Klotz-Noack, K., Schwarz, R.F. ORCID: https://orcid.org/0000-0001-9155-4268, Sawitzki, B., Kamphues, C., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Sers, C., Horst, D. ORCID: https://orcid.org/0000-0003-4755-5743, Blüthgen, N. ORCID: https://orcid.org/0000-0002-0171-7447 and Morkel, M. ORCID: https://orcid.org/0000-0002-2553-9999
EMBO Molecular Medicine 13
(10): e14123.
7 October 2021
Endocrine Connections
Generation and characterization of a mitotane-resistant adrenocortical cell line.
Seidel, E., Walenda, G., Messerschmidt, C. ORCID: https://orcid.org/0000-0001-8632-656X, Obermayer, B. ORCID: https://orcid.org/0000-0002-9116-630X, Peitzsch, M., Wallace, P., Bahethi, R., Yoo, T., Choi, M., Schrade, P., Bachmann, S., Liebisch, G., Eisenhofer, G., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632 and Scholl, U.
Endocrine Connections 9
(2): 122-134.
February 2020
European Journal of Cancer
Feasibility analysis of using patient-derived tumour organoids for treatment decision guidance in locally advanced head and neck squamous cell carcinoma.
Fischer, A.S. ORCID: https://orcid.org/0000-0002-2176-1779, Pestana, A., Sachse, V., Doll, C., Hofmann, E., Heiland, M., Obermueller, T., Heidemann, J., Dommerich, S., Schoppe, D., Schallenberg, S., Piwonski, I., Blanc, E. ORCID: https://orcid.org/0000-0002-4369-0254 and Tinhofer, I.
European Journal of Cancer 213
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December 2024
Benchmarking whole exome sequencing in the German network for personalized medicine.
Menzel, M., Martis-Thiele, M., Goldschmid, H., Ott, A., Romanovsky, E., Siemanowski-Hrach, J., Seillier, L., Brüchle, N.O., Maurer, A., Lehmann, K.V., Begemann, M., Elbracht, M., Meyer, R., Dintner, S., Claus, R., Meier-Kolthoff, J.P, Blanc, E. ORCID: https://orcid.org/0000-0002-4369-0254, Möbs, M., Joosten, M., Benary, M. ORCID: https://orcid.org/0000-0002-3067-2030, Basitta, P., Hölscher, F., Tischler, V., Groß, T., Kutz, O., Prause, R., William, D., Horny, Kai, Goering, W., Sivalingam, S., Borkhardt, A., Blank, C., Junk, S.V., Yasin, L., Moskalev, E.A., Carta, M.G., Ferrazzi, F., Tögel, L., Wolter, S., Adam, E., Matysiak, U., Rosenthal, T., Dönitz, J., Lehmann, U., Schmidt, G., Bartels, S., Hofmann, W., Hirsch, S., Dikow, N., Göbel, K., Banan, R., Hamelmann, S., Fink, A., Ball, M., Neumann, O., Rehker, J., Kloth, M., Murtagh, J., Hartmann, N., Jurmeister, P., Mock, A., Kumbrink, J., Jung, A., Mayr, E.M., Jacob, A., Trautmann, M., Kirmse, S., Falkenberg, K., Ruckert, C., Hirsch, D., Immel, A., Dietmaier, W., Haack, T., Marienfeld, R., Fürstberger, A., Niewöhner, J., Gerstenmaier, U., Eberhardt, T., Greif, P.A., Appenzeller, S., Maurus, K., Doll, J., Jelting, Y., Jonigk, D., Märkl, B., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Horst, D., Wulf, A.L., Aust, D., Werner, M., Reuter-Jessen, K., Ströbel, P., Auber, B., Sahm, F., Merkelbach-Bruse, S., Siebolts, U., Roth, W., Lassmann, S., Klauschen, F., Gaisa, N.T., Weichert, W., Evert, M., Armeanu-Ebinger, S., Ossowski, S., Schroeder, C., Schaaf, C.P., Malek, N., Schirmacher, P., Kazdal, D., Pfarr, N., Budczies, J. and Stenzinger, A.
European Journal of Cancer 211
: 114306.
November 2024
Tumour mutational burden and survival with molecularly matched therapy.
de Bortoli, T., Benary, M. ORCID: https://orcid.org/0000-0002-3067-2030, Horak, P., Lamping, M., Stintzing, S., Tinhofer, I., Leyvraz, S., Schäfer, R., Klauschen, F., Keller, U. ORCID: https://orcid.org/0000-0002-8485-1958, Stenzinger, A., Fröhling, S., Kurzrock, R., Keilholz, U., Rieke, D.T. and Jelas, I.
European Journal of Cancer 190
: 112925.
September 2023
Support of a molecular tumour board by an evidence-based decision management system for precision oncology.
Lamping, M., Benary, M. ORCID: https://orcid.org/0000-0002-3067-2030, Leyvraz, S., Messerschmidt, C. ORCID: https://orcid.org/0000-0001-8632-656X, Blanc, E. ORCID: https://orcid.org/0000-0002-4369-0254, Kessler, T., Schütte, M., Lenze, D., Jöhrens, K., Burock, S., Klinghammer, K. ORCID: https://orcid.org/0000-0001-6425-4833, Ochsenreither, S., Sers, C., Schäfer, R., Tinhofer, I., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Klauschen, F., Yaspo, M.L., Keilholz, U. and Rieke, D.T.
European Journal of Cancer 127
: 41-51.
March 2020
European Journal of Human Genetics
Combining callers improves the detection of copy number variants from whole-genome sequencing.
Coutelier, M. ORCID: https://orcid.org/0000-0002-0261-7210, Holtgrewe, M. ORCID: https://orcid.org/0000-0002-3051-1763, Jäger, M., Flöttman, R., Mensah, M.A. ORCID: https://orcid.org/0000-0001-8080-8779, Spielmann, M., Krawitz, P. ORCID: https://orcid.org/0000-0002-3194-8625, Horn, D., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632 and Mundlos, S. ORCID: https://orcid.org/0000-0002-9788-3166
European Journal of Human Genetics 30
(2): 178-186.
February 2022
European Journal of Paediatric Neurology
Paroxysmal tonic upgaze: a heterogeneous clinical condition responsive to carbonic anhydrase inhibition.
Quade, A., Thiel, A., Kurth, I., Holtgrewe, M. ORCID: https://orcid.org/0000-0002-3051-1763, Elbracht, M., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Eggermann, K., Scholl, U.I. and Häusler, M.
European Journal of Paediatric Neurology 25
: 181-186.
March 2020
European Journal of Pharmaceutical Sciences
Transcriptome analysis reveals involvement of thiopurine S-methyltransferase in oxidation-reduction processes.
Šmid, A. ORCID: https://orcid.org/0000-0001-7142-7202, Štajdohar, M., Milek, M. ORCID: https://orcid.org/0000-0002-0803-8439, Urbančič, D., Karas Kuželički, N., Tamm, R., Metspalu, A. and Mlinarič-Raščan, I.
European Journal of Pharmaceutical Sciences 192
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1 January 2024
European Respiratory Journal
Microenvironmental acidification by pneumococcal sugar consumption fosters barrier disruption and immune suppression in the human alveolus.
Fatykhova, D., Fritsch, V.N. ORCID: https://orcid.org/0000-0002-7598-6754, Siebert, K., Methling, K., Lalk, M., Busche, T., Kalinowski, J., Weiner, J. ORCID: https://orcid.org/0000-0003-1438-7819, Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Bertrams, W., Kohler, T.P., Hammerschmidt, S., Löwa, A., Fischer, M. ORCID: https://orcid.org/0000-0003-2674-8001, Mieth, M., Hellwig, K., Frey, D., Neudecker, J., Rueckert, J.C., Toennies, M., Bauer, T.T., Graff, M., Tran, H.L., Eggeling, S., Gruber, A.D., Antelmann, H., Hippenstiel, S. and Hocke, A.C.
European Respiratory Journal 64
(6): 2301983.
December 2024
Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages.
Hönzke, K., Obermayer, B. ORCID: https://orcid.org/0000-0002-9116-630X, Mache, C., Fathykova, D., Kessler, M., Dökel, S., Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Baumgardt, M., Löwa, A., Hoffmann, K., Graff, P., Schulze, J., Mieth, M., Hellwig, K., Demir, Z., Biere, B., Brunotte, L., Mecate-Zambrano, A., Bushe, J., Dohmen, M. ORCID: https://orcid.org/0000-0002-4447-0579, Hinze, C. ORCID: https://orcid.org/0000-0003-2526-1621, Elezkurtaj, S., Tönnies, M., Bauer, T.T., Eggeling, S., Tran, H.L., Schneider, P., Neudecker, J., Rückert, J.C., Schmidt-Ott, K.M. ORCID: https://orcid.org/0000-0002-7700-7142, Busch, J., Klauschen, F., Horst, D., Radbruch, H. ORCID: https://orcid.org/0000-0001-6941-3397, Radke, J., Heppner, F., Corman, V.M., Niemeyer, D., Müller, M.A., Goffinet, C., Mothes, R., Pascual-Reguant, A., Hauser, A.E., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Ludwig, S., Suttorp, N., Witzenrath, M., Gruber, A.D., Drosten, C., Sander, L.E., Wolff, T., Hippenstiel, S. and Hocke, A.C.
European Respiratory Journal 60
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1 December 2022
Prediction of anti-tuberculosis treatment duration based on a 22-gene transcriptomic model.
Heyckendorf, Jan ORCID: https://orcid.org/0000-0003-4203-8421, Marwitz, Sebastian, Reimann, Maja ORCID: https://orcid.org/0000-0002-2385-2287, Avsar, Korkut, DiNardo, Andrew R., Günther, Gunar, Hoelscher, Michael ORCID: https://orcid.org/0000-0002-7642-1835, Ibraim, Elmira, Kalsdorf, Barbara, Kaufmann, Stefan H.E., Kontsevaya, Irina, van Leth, Frank ORCID: https://orcid.org/0000-0002-5490-8968, Mandalakas, Anna M. ORCID: https://orcid.org/0000-0002-8091-3509, Maurer, Florian P. ORCID: https://orcid.org/0000-0001-8353-5964, Müller, Marius, Nitschkowski, Dörte, Olaru, Ioana D. ORCID: https://orcid.org/0000-0003-3392-9257, Popa, Cristina, Rachow, Andrea, Rolling, Thierry ORCID: https://orcid.org/0000-0002-0277-5067, Rybniker, Jan, Salzer, Helmut J.F., Sanchez-Carballo, Patricia, Schuhmann, Maren, Schaub, Dagmar, Spinu, Victor, Suárez, Isabelle ORCID: https://orcid.org/0000-0002-9863-9675, Terhalle, Elena, Unnewehr, Markus, Weiner 3rd, January ORCID: https://orcid.org/0000-0003-1438-7819, Goldmann, Torsten ORCID: https://orcid.org/0000-0002-1621-560X and Lange, Christoph
European Respiratory Journal 58
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September 2021
European Respiratory Review
A pulmonologist's guide to perform and analyse cross-species single lung cell transcriptomics.
Pennitz, P. ORCID: https://orcid.org/0000-0002-8132-7237, Kirsten, H., Friedrich, V.D., Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Goekeri, C. ORCID: https://orcid.org/0000-0002-1616-4005, Obermayer, B. ORCID: https://orcid.org/0000-0002-9116-630X, Heinz, G.A., Mashreghi, M.F. ORCID: https://orcid.org/0000-0002-8015-6907, Büttner, M., Trimpert, J., Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Suttorp, N., Hocke, A.C., Hippenstiel, S., Tönnies, M., Scholz, M., Kuebler, W.M., Witzenrath, M., Hoenzke, K. and Nouailles, G. ORCID: https://orcid.org/0000-0003-1973-3119
European Respiratory Review 31
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30 September 2022
Frontiers in Genetics
Venn diagrams may indicate erroneous statistical reasoning in transcriptomics.
Weiner, J. ORCID: https://orcid.org/0000-0003-1438-7819, Obermayer, B. ORCID: https://orcid.org/0000-0002-9116-630X and Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632
Frontiers in Genetics 13
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14 April 2022
Frontiers in Immunology
Pronounced impairment of B cell differentiation during bone regeneration in adult immune experienced mice.
Tchouto, M.N., Bucher, C.H., Mess, A.K., Haas, S. ORCID: https://orcid.org/0000-0001-9227-2051, Schmidt-Bleek, K., Duda, G.N., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632 and Milek, M. ORCID: https://orcid.org/0000-0002-0803-8439
Frontiers in Immunology 16
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3 March 2025
Single-cell clonal tracking of persistent T-cells in allogeneic hematopoietic stem cell transplantation.
Obermayer, B. ORCID: https://orcid.org/0000-0002-9116-630X, Keilholz, L., Conrad, T. ORCID: https://orcid.org/0000-0001-5618-6295, Frentsch, M., Blau, I.W., Vuong, L., Lesch, S., Movasshagi, K., Tietze-Stolley, C., Loyal, L., Henze, L., Penack, O., Stervbo, U. ORCID: https://orcid.org/0000-0002-2831-8868, Babel, N., Haas, S. ORCID: https://orcid.org/0000-0001-9227-2051, Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Bullinger, L. ORCID: https://orcid.org/0000-0002-5890-5510, Wittenbecher, F. and Na, I.K. ORCID: https://orcid.org/0000-0001-9902-5424
Frontiers in Immunology 14
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10 February 2023
Systematic evaluation of kinetics and distribution of muscle and lymph node activation measured by (18)F-FDG- and (11)C-PBR28-PET/CT imaging, and whole blood and muscle transcriptomics after immunization of healthy humans with adjuvanted and unadjuvanted vaccines.
Win, Z., Weiner 3rd, J. ORCID: https://orcid.org/0000-0003-1438-7819, Listanco, A., Patel, N., Sharma, R., Greenwood, A., Maertzdorf, J., Mollenkopf, H.J., Pizzoferro, K., Cole, T., Bodinham, C.L., Kaufmann, S.H.E., Denoel, P., Del Giudice, S. ORCID: https://orcid.org/0000-0003-0194-3767 and Lewis, D.J.M.
Frontiers in Immunology 11
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5 February 2021
Parasitic nematodes exert antimicrobial activity and benefit from microbiota-driven support for host immune regulation.
Rausch, S., Midha, A., Kuhring, M. ORCID: https://orcid.org/0000-0002-3287-0313, Affinass, N., Radonic, A., Kühl, A.A., Bleich, A., Renard, B.Y. and Hartmann, S.
Frontiers in Immunology 9
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October 2018
Silent witness: dual-species transcriptomics reveals epithelial immunological quiescence to helminth larval encounter and fostered larval development.
Ebner, F., Kuhring, M. ORCID: https://orcid.org/0000-0002-3287-0313, Radonic, A., Midha, A., Renard, B.Y. and Hartmann, S.
Frontiers in Immunology 9
: 1868.
15 August 2018
Frontiers in Oncology
Targeted treatment in a case series of AR+, HRAS/PIK3CA co-mutated salivary duct carcinoma.
Rieke, D.T., Schröder, S., Schafhausen, P., Blanc, E. ORCID: https://orcid.org/0000-0002-4369-0254, Zuljan, E., von der Emde, B., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Keller, U. ORCID: https://orcid.org/0000-0002-8485-1958, Keilholz, U. and Klinghammer, K. ORCID: https://orcid.org/0000-0001-6425-4833
Frontiers in Oncology 13
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2023
Gastroenterology
Multimodal profiling of peripheral blood identifies proliferating circulating effector CD4(+) T cells as predictors for response to integrin α4β7-blocking therapy in inflammatory bowel disease.
Horn, V., Cancino, C.A., Steinheuer, L.M., Obermayer, B. ORCID: https://orcid.org/0000-0002-9116-630X, Fritz, K., Nguyen, A.L., Juhran, K.S., Plattner, C., Bösel, D., Oldenburg, L., Burns, M., Schulz, A.R., Saliutina, M., Mantzivi, E., Lissner, D., Conrad, T. ORCID: https://orcid.org/0000-0001-5618-6295, Mashreghi, M.F., Zundler, S., Sonnenberg, E., Schumann, M., Haag, L.M., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Flatz, L., Trjanoski, Z., D'Haens, G., Weidinger, C., Mei, H.E., Siegmund, B., Thurley, K. and Hegazy, A.N.
Gastroenterology 168
(2): 327-343.
February 2025
Genes
Enhancing variant prioritization in VarFish through on-premise computational facial analysis.
Bhasin, M.A. ORCID: https://orcid.org/0009-0000-2944-6880, Knaus, A. ORCID: https://orcid.org/0000-0003-0366-0533, Incardona, P., Schmid, A., Holtgrewe, M. ORCID: https://orcid.org/0000-0002-3051-1763, Elbracht, M. ORCID: https://orcid.org/0000-0001-5088-1369, Krawitz, P.M. ORCID: https://orcid.org/0000-0002-3194-8625 and Hsieh, T.C. ORCID: https://orcid.org/0000-0003-3037-8728
Genes 15
(3): 370.
March 2024
Genetics in Medicine
CDK19-related disorder results from both loss-of-function and gain-of-function de novo missense variants.
Zarate, Y.A., Uehara, T., Abe, K., Oginuma, M., Harako, S., Ishitani, S., Lehesjoki, A.E., Bierhals, T., Kloth, K., Ehmke, N., Horn, D., Holtgrewe, M. ORCID: https://orcid.org/0000-0002-3051-1763, Anderson, K., Viskochil, D., Edgar-Zarate, C.L., Sacoto, M.J.Guillen, Schnur, R.E., Morrow, M.M., Sanchez-Valle, A., Pappas, J., Rabin, R., Muona, M., Anttonen, A.K., Platzer, K., Luppe, J., Gburek-Augustat, J., Kaname, T., Okamoto, N., Mizuno, S., Kaido, Y., Ohkuma, Y., Hirose, Y., Ishitani, T. and Kosaki, K.
Genetics in Medicine 23
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June 2021
Genome Medicine
A proteomics analysis of 5xFAD mouse brain regions reveals the lysosome-associated protein Arl8b as a candidate biomarker for Alzheimer's disease.
Boeddrich, A. ORCID: https://orcid.org/0000-0001-9118-050X, Haenig, C. ORCID: https://orcid.org/0000-0003-1973-7646, Neuendorf, N., Blanc, E. ORCID: https://orcid.org/0000-0002-4369-0254, Ivanov, A. ORCID: https://orcid.org/0000-0002-4824-1925, Kirchner, M. ORCID: https://orcid.org/0000-0002-7049-534X, Schleumann, P., Bayraktaroğlu, I., Richter, M. ORCID: https://orcid.org/0000-0002-5339-0781, Molenda, C.M. ORCID: https://orcid.org/0000-0003-0771-405X, Sporbert, A. ORCID: https://orcid.org/0000-0002-3738-1295, Zenkner, M., Schnoegl, S., Suenkel, C. ORCID: https://orcid.org/0000-0002-5326-6043, Schneider, L.S., Rybak-Wolf, A. ORCID: https://orcid.org/0000-0002-1192-5290, Kochnowsky, B., Byrne, L.M., Wild, E.J., Nielsen, J.E., Dittmar, G. ORCID: https://orcid.org/0000-0003-3647-8623, Peters, O. ORCID: https://orcid.org/0000-0003-0568-2998, Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632 and Wanker, E.E. ORCID: https://orcid.org/0000-0001-8072-1630
Genome Medicine 15
(1): 50.
20 July 2023
Single-cell transcriptomics reveals common epithelial response patterns in human acute kidney injury.
Hinze, C. ORCID: https://orcid.org/0000-0003-2526-1621, Kocks, C. ORCID: https://orcid.org/0000-0003-1749-3334, Leiz, J. ORCID: https://orcid.org/0000-0002-6531-7047, Karaiskos, N. ORCID: https://orcid.org/0000-0001-7771-3947, Boltengagen, A. ORCID: https://orcid.org/0000-0002-8356-9766, Cao, S. ORCID: https://orcid.org/0000-0001-7195-8193, Skopnik, C.M. ORCID: https://orcid.org/0000-0002-6089-4769, Klocke, J. ORCID: https://orcid.org/0000-0002-7723-9234, Hardenberg, J.H. ORCID: https://orcid.org/0000-0001-9548-2118, Stockmann, H. ORCID: https://orcid.org/0000-0002-0934-7620, Gotthardt, I. ORCID: https://orcid.org/0000-0001-6033-0093, Obermayer, B. ORCID: https://orcid.org/0000-0002-9116-630X, Haghverdi, L. ORCID: https://orcid.org/0000-0001-9280-9170, Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Bachmann, S., Hocke, A.C. ORCID: https://orcid.org/0000-0002-6935-8612, Corman, V., Busch, J., Schneider, W., Himmerkus, N. ORCID: https://orcid.org/0000-0002-2910-6728, Bleich, M. ORCID: https://orcid.org/0000-0002-1745-2295, Eckardt, K.U. ORCID: https://orcid.org/0000-0003-3823-0920, Enghard, P. ORCID: https://orcid.org/0000-0002-7254-3931, Rajewsky, N. ORCID: https://orcid.org/0000-0002-4785-4332 and Schmidt-Ott, K.M. ORCID: https://orcid.org/0000-0002-7700-7142
Genome Medicine 14
(1): 103.
9 September 2022
GigaScience
SODAR: managing multiomics study data and metadata.
Nieminen, M. ORCID: https://orcid.org/0000-0002-4180-8810, Stolpe, O. ORCID: https://orcid.org/0000-0002-8686-2941, Kuhring, M. ORCID: https://orcid.org/0000-0002-3287-0313, Weiner, J. ORCID: https://orcid.org/0000-0003-1438-7819, Pett, P. ORCID: https://orcid.org/0000-0002-5249-444X, Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632 and Holtgrewe, M. ORCID: https://orcid.org/0000-0002-3051-1763
GigaScience 12
: giad052.
27 July 2023
Heliyon
Harnessing transcriptomic signals for amyotrophic lateral sclerosis to identify novel drugs and enhance risk prediction.
Pain, O. ORCID: https://orcid.org/0000-0001-5680-3281, Jones, A., Al Khleifat, A., Agarwal, D., Hramyka, D., Karoui, H., Kubica, J., Llewellyn, D.J., Ranson, J.M., Yao, Z., Iacoangeli, A. and Al-Chalabi, A.
Heliyon 10
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15 August 2024
Human Genetics
lncRNA CDKN2B-AS1 regulates collagen expression.
Shi, W., Song, J., Weiner, J.M. ORCID: https://orcid.org/0000-0003-1438-7819, Chopra, A., Dommisch, H., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632 and Schaefer, A.S.
Human Genetics 143
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July 2024
Loss-of-function variants affecting the STAGA complex component SUPT7L cause a developmental disorder with generalized lipodystrophy.
Kopp, J. ORCID: https://orcid.org/0000-0002-0391-1497, Koch, L.A. ORCID: https://orcid.org/0000-0003-4943-198X, Lyubenova, H. ORCID: https://orcid.org/0000-0002-5590-3835, Küchler, O. ORCID: https://orcid.org/0009-0008-2628-2890, Holtgrewe, M. ORCID: https://orcid.org/0000-0002-3051-1763, Ivanov, A. ORCID: https://orcid.org/0000-0002-4824-1925, Dubourg, C. ORCID: https://orcid.org/0000-0003-1345-4522, Launay, E. ORCID: https://orcid.org/0000-0003-1546-7319, Brachs, S. ORCID: https://orcid.org/0000-0002-6336-3939, Mundlos, S. ORCID: https://orcid.org/0000-0002-9788-3166, Ehmke, N. ORCID: https://orcid.org/0000-0003-1449-9909, Seelow, D. ORCID: https://orcid.org/0000-0002-9746-4412, Fradin, M. ORCID: https://orcid.org/0000-0002-2535-2198, Kornak, U. ORCID: https://orcid.org/0000-0002-4582-9838 and Fischer-Zirnsak, B. ORCID: https://orcid.org/0000-0002-1075-7571
Human Genetics 143
(5): 683-694.
May 2024
Transmission ratio distortion of mutations in the master regulator of centriole biogenesis PLK4.
Neitzel, H., Varon, R., Chughtai, S., Dartsch, J. ORCID: https://orcid.org/0000-0002-7947-2881, Dutrannoy-Tönsing, V., Nürnberg, P., Nürnberg, G., Schweiger, M., Digweed, M., Hildebrand, G., Hackmann, K., Holtgrewe, M. ORCID: https://orcid.org/0000-0002-3051-1763, Sarioglu, N., Schulze, B., Horn, D. and Sperling, K. ORCID: https://orcid.org/0000-0003-2305-4370
Human Genetics 141
(11): 1785-1794.
November 2022
Complete lung agenesis caused by complex genomic rearrangements with neo-TAD formation at the SHH locus.
Melo, U.S., Piard, J., Fischer-Zirnsak, B., Klever, M.K., Schöpflin, R., Mensah, M.A., Holtgrewe, M. ORCID: https://orcid.org/0000-0002-3051-1763, Arbez-Gindre, F., Martin, A., Guigue, V., Gaillard, D., Landais, E., Roze, V., Kremer, V., Ramanah, R., Cabrol, C., Harms, F.L., Kornak, U., Spielmann, M., Mundlos, S. and Van Maldergem, L.
Human Genetics 140
(10): 1459-1469.
October 2021
Genome sequencing in families with congenital limb malformations.
Elsner, J., Mensah, M.A., Holtgrewe, M. ORCID: https://orcid.org/0000-0002-3051-1763, Hertzberg, J., Bigoni, S., Busche, A., Coutelier, M. ORCID: https://orcid.org/0000-0002-0261-7210, de Silva, D.C., Elçioglu, N., Filges, I., Gerkes, E., Girisha, K.M., Graul-Neumann, L., Jamsheer, A., Krawitz, P., Kurth, I., Markus, S., Megarbane, A., Reis, A., Reuter, M.S., Svoboda, D., Teller, C., Tuysuz, B., Türkmen, S., Wilson, M., Woitschach, R., Vater, I., Caliebe, A., Hülsemann, W., Horn, D., Mundlos, S. and Spielmann, M.
Human Genetics 140
(8): 1229-1239.
August 2021
Human Genetics and Genomics Advances
Prioritization of non-coding elements involved in non-syndromic cleft lip with/without cleft palate through genome-wide analysis of de novo mutations.
Zieger, H.K., Weinhold, L., Schmidt, A., Holtgrewe, M. ORCID: https://orcid.org/0000-0002-3051-1763, Juranek, S.A., Siewert, A., Scheer, A.B., Thieme, F., Mangold, E., Ishorst, N., Brand, F.U., Welzenbach, J., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Paeschke, K., Krawitz, P.M. ORCID: https://orcid.org/0000-0002-3194-8625 and Ludwig, K.U. ORCID: https://orcid.org/0000-0002-8541-2519
Human Genetics and Genomics Advances 4
(1): 100166.
12 January 2023
Immunity
Microglial lipid phosphatase SHIP1 limits complement-mediated synaptic pruning in the healthy developing hippocampus.
Matera, A., Compagnion, A.C., Pedicone, C., Janssen, M.K., Ivanov, A. ORCID: https://orcid.org/0000-0002-4824-1925, Monsorno, K., Labouèbe, G., Leggio, L., Pereira, M., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Mansuy-Aubert, V., Williams, T.L., Iraci, N., Sierra, A., Marro, S.G., Goate, A.M., Eggen, B.L., Kerr, W.G. and Paolicelli, R.C.
Immunity 58
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14 January 2025
International Journal of Cancer
High-confidence calling of normal epithelial cells allows identification of a novel stem-like cell state in the colorectal cancer microenvironment.
Wei, T.T. ORCID: https://orcid.org/0000-0001-5719-721X, Blanc, E. ORCID: https://orcid.org/0000-0002-4369-0254, Peidli, S. ORCID: https://orcid.org/0000-0002-4257-8690, Bischoff, P. ORCID: https://orcid.org/0000-0002-4442-7116, Trinks, A. ORCID: https://orcid.org/0000-0001-9983-1506, Horst, D. ORCID: https://orcid.org/0000-0003-4755-5743, Sers, C. ORCID: https://orcid.org/0000-0002-6219-1514, Blüthgen, N. ORCID: https://orcid.org/0000-0002-0171-7447, Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Morkel, M. ORCID: https://orcid.org/0000-0002-2553-9999 and Obermayer, B. ORCID: https://orcid.org/0000-0002-9116-630X
International Journal of Cancer 155
(9): 1655-1669.
1 November 2024
The single-cell transcriptional landscape of lung carcinoid tumors.
Bischoff, P. ORCID: https://orcid.org/0000-0002-4442-7116, Trinks, A. ORCID: https://orcid.org/0000-0001-9983-1506, Wiederspahn, J. ORCID: https://orcid.org/0000-0003-0117-9754, Obermayer, B. ORCID: https://orcid.org/0000-0002-9116-630X, Pett, J.P. ORCID: https://orcid.org/0000-0002-5249-444X, Jurmeister, P. ORCID: https://orcid.org/0000-0001-7745-3794, Elsner, A., Dziodzio, T. ORCID: https://orcid.org/0000-0002-3337-4573, Rückert, J.C., Neudecker, J., Falk, C. ORCID: https://orcid.org/0000-0003-1376-7318, Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Sers, C. ORCID: https://orcid.org/0000-0002-6219-1514, Morkel, M. ORCID: https://orcid.org/0000-0002-2553-9999, Horst, D. ORCID: https://orcid.org/0000-0003-4755-5743, Klauschen, F. ORCID: https://orcid.org/0000-0002-9131-2389 and Blüthgen, N. ORCID: https://orcid.org/0000-0002-0171-7447
International Journal of Cancer 150
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15 June 2022
Long-term in vitro expansion ensures increased yield of central memory T cells as perspective for manufacturing challenges.
Herda, S., Heimann, A., Obermayer, B. ORCID: https://orcid.org/0000-0002-9116-630X, Ciraolo, E. ORCID: https://orcid.org/0000-0002-5601-1695, Althoff, S., Ruß, J., Grunert, C. ORCID: https://orcid.org/0000-0001-8376-8629, Busse, A. ORCID: https://orcid.org/0000-0002-3470-6947, Bullinger, L. ORCID: https://orcid.org/0000-0002-5890-5510, Pezzutto, A. ORCID: https://orcid.org/0000-0002-3246-4470, Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321, Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632 and Na, I.K. ORCID: https://orcid.org/0000-0001-9902-5424
International Journal of Cancer 148
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15 June 2021
Distinct immune evasion in APOBEC-enriched, HPV-negative HNSCC.
Messerschmidt, C. ORCID: https://orcid.org/0000-0001-8632-656X, Obermayer, B. ORCID: https://orcid.org/0000-0002-9116-630X, Klinghammer, K. ORCID: https://orcid.org/0000-0001-6425-4833, Ochsenreither, S. ORCID: https://orcid.org/0000-0001-6024-4312, Treue, D. ORCID: https://orcid.org/0000-0002-0657-5505, Stenzinger, A. ORCID: https://orcid.org/0000-0003-1001-103X, Glimm, H., Fröhling, S. ORCID: https://orcid.org/0000-0001-7907-4595, Kindler, T., Brandts, C.H., Schulze-Osthoff, K., Weichert, W., Tinhofer, I. ORCID: https://orcid.org/0000-0002-0512-549X, Klauschen, F., Keilholz, U. ORCID: https://orcid.org/0000-0001-6773-9406, Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632 and Rieke, D.T. ORCID: https://orcid.org/0000-0003-0027-7977
International Journal of Cancer 147
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15 October 2020
Reflection of neuroblastoma intratumor heterogeneity in the new OHC-NB1 disease model.
Thole, T.M., Toedling, J. ORCID: https://orcid.org/0000-0003-1471-1295, Sprüssel, A. ORCID: https://orcid.org/0000-0001-6079-5907, Pfeil, S., Savelyeva, L., Capper, D., Messerschmidt, C. ORCID: https://orcid.org/0000-0001-8632-656X, Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Groeneveld-Krentz, S., Eckert, C., Gambara, G., Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X, Finkler, S., Schulte, J.H., Sieber, A., Bluethgen, N. ORCID: https://orcid.org/0000-0002-0171-7447, Regenbrecht, C.R.A., Künkele, A., Lodrini, M., Eggert, A. and Deubzer, H.E. ORCID: https://orcid.org/0000-0002-6115-4893
International Journal of Cancer 146
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15 February 2020
International Journal of Molecular Sciences
Placental transcriptome profiling in subtypes of diabetic pregnancies is strongly confounded by fetal sex.
Kedziora, S.M. ORCID: https://orcid.org/0000-0003-0124-2557, Obermayer, B. ORCID: https://orcid.org/0000-0002-9116-630X, Sugulle, M., Herse, F. ORCID: https://orcid.org/0000-0002-9305-8134, Kräker, K. ORCID: https://orcid.org/0000-0002-4032-5382, Haase, N. ORCID: https://orcid.org/0000-0003-0727-1738, Langmia, I.M. ORCID: https://orcid.org/0000-0002-5862-708X, Müller, D.N. ORCID: https://orcid.org/0000-0003-3650-5644, Staff, A.C., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632 and Dechend, R. ORCID: https://orcid.org/0000-0001-6636-3080
International Journal of Molecular Sciences 23
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6 December 2022
Analyses of circRNA expression throughout the light-dark cycle reveal a strong regulation of (Cdr1as), associated with light entrainment in the SCN.
Ivanov, A. ORCID: https://orcid.org/0000-0002-4824-1925, Mattei, D. ORCID: https://orcid.org/0000-0001-6221-9321, Radscheit, K., Compagnion, A.C., Pett, J.P. ORCID: https://orcid.org/0000-0002-5249-444X, Herzel, H.P. ORCID: https://orcid.org/0000-0003-0414-7889, Paolicelli, R.C. ORCID: https://orcid.org/0000-0001-6851-0849, Piwecka, M. ORCID: https://orcid.org/0000-0003-4104-6577, Meyer, U. ORCID: https://orcid.org/0000-0001-7244-0345 and Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632
International Journal of Molecular Sciences 23
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October 2022
Enzymatic dissociation induces transcriptional and proteotype bias in brain cell populations.
Mattei, D. ORCID: https://orcid.org/0000-0001-6221-9321, Ivanov, A. ORCID: https://orcid.org/0000-0002-4824-1925, van Oostrum, M. ORCID: https://orcid.org/0000-0001-8747-9787, Pantelyushin, S. ORCID: https://orcid.org/0000-0002-3490-3860, Richetto, J. ORCID: https://orcid.org/0000-0002-8313-3348, Mueller, F., Beffinger, M., Schellhammer, L., Vom Berg, J. ORCID: https://orcid.org/0000-0002-4086-1564, Wollscheid, B. ORCID: https://orcid.org/0000-0002-3923-1610, Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Paolicelli, R.C. ORCID: https://orcid.org/0000-0001-6851-0849 and Meyer, U.
International Journal of Molecular Sciences 21
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1 November 2020
JAMA Network Open
Leveraging large language models for decision support in personalized oncology.
Benary, M. ORCID: https://orcid.org/0000-0002-3067-2030, Wang, X.D., Schmidt, M., Soll, D., Hilfenhaus, G. ORCID: https://orcid.org/0000-0001-8764-077X, Nassir, M., Sigler, C., Knödler, M., Keller, U. ORCID: https://orcid.org/0000-0002-8485-1958, Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Keilholz, U., Leser, U. and Rieke, D.T.
JAMA Network Open 6
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November 2023
Journal of Cardiovascular Development and Disease
Pathogenic variants in cardiomyopathy disorder genes underlie pediatric myocarditis - Further impact of heterozygous immune disorder gene variants?
Seidel, F. ORCID: https://orcid.org/0000-0002-1328-1580, Laser, K.T., Klingel, K. ORCID: https://orcid.org/0000-0003-0203-2498, Dartsch, J. ORCID: https://orcid.org/0000-0002-7947-2881, Theisen, S., Pickardt, T. ORCID: https://orcid.org/0000-0003-0019-6325, Holtgrewe, M. ORCID: https://orcid.org/0000-0002-3051-1763, Gärtner, A. ORCID: https://orcid.org/0000-0001-6899-7693, Berger, F., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Milting, H. ORCID: https://orcid.org/0000-0001-9722-0007, Schubert, S., Klaassen, S. ORCID: https://orcid.org/0000-0001-5925-9912 and Kühnisch, J. ORCID: https://orcid.org/0000-0003-4744-5421
Journal of Cardiovascular Development and Disease 9
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5 July 2022
Journal of Cerebral Blood Flow and Metabolism
An exploratory investigation of brain collateral circulation plasticity after cerebral ischemia in two experimental C57BL/6 mouse models.
Foddis, M., Winek, K., Bentele, K., Mueller, S., Blumenau, S. ORCID: https://orcid.org/0000-0002-6606-3800, Reichhart N, N., Crespo-Garcia, S. ORCID: https://orcid.org/0000-0002-8640-9135, Harnett, D. ORCID: https://orcid.org/0000-0002-9190-128X, Ivanov, A. ORCID: https://orcid.org/0000-0002-4824-1925, Meisel, A., Joussen, A., Strauss, O., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Dirnagl, U. and Sassi, C.
Journal of Cerebral Blood Flow and Metabolism 40
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1 February 2020
Journal of Clinical Periodontology
RSPO4 is a potential risk gene of stages III–IV, grade C periodontitis through effects on innate immune response and oral barrier integrity.
Chopra, A., Song, J., Weiner 3rd, J. ORCID: https://orcid.org/0000-0003-1438-7819, Keceli, H.G. ORCID: https://orcid.org/0000-0001-6695-2133, Dincer, P.R., Cruz, R., Carracedo, A., Blanco, J. ORCID: https://orcid.org/0000-0001-9251-513X, Dommisch, H. ORCID: https://orcid.org/0000-0003-1043-2651 and Schaefer, A.S. ORCID: https://orcid.org/0000-0001-5816-6765
Journal of Clinical Periodontology 50
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April 2023
Case-only design identifies interactions of genetic risk variants at SIGLEC5 and PLG with the lncRNA CTD-2353F22.1 implying the importance of periodontal wound healing for disease aetiology.
Müller, R., Freitag‐Wolf, S., Weiner 3rd, J. ORCID: https://orcid.org/0000-0003-1438-7819, Chopra, A., Top, T., Dommisch, H. ORCID: https://orcid.org/0000-0003-1043-2651 and Schaefer, A.S. ORCID: https://orcid.org/0000-0001-5816-6765
Journal of Clinical Periodontology 50
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January 2023
Journal of Dental Research
miRNAs from inflamed gingiva link gene signaling to increased MET expression.
Zheng, L., Chopra, A., Weiner, J. ORCID: https://orcid.org/0000-0003-1438-7819, Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Dommisch, H. ORCID: https://orcid.org/0000-0003-1043-2651 and Schaefer, A.S.
Journal of Dental Research 102
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December 2023
Exome sequencing of 5 families with severe early-onset periodontitis.
Richter, G.M., Wagner, G., Reichenmiller, K., Staufenbiel, I., Martins, O., Löscher, B.S., Holtgrewe, M. ORCID: https://orcid.org/0000-0002-3051-1763, Jepsen, S., Dommisch, H. ORCID: https://orcid.org/0000-0003-1043-2651 and Schaefer, A.S.
Journal of Dental Research 101
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February 2022
BACH1 binding links the genetic risk for severe periodontitis with ST8SIA1.
Chopra, A. ORCID: https://orcid.org/0000-0001-7706-3577, Mueller, R., Weiner 3rd, J. ORCID: https://orcid.org/0000-0003-1438-7819, Rosowski, J., Dommisch, H. ORCID: https://orcid.org/0000-0003-1043-2651, Grohmann, E. and Schaefer, A.S.
Journal of Dental Research 101
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January 2022
Entamoeba gingivalis exerts severe pathogenic effects on the oral mucosa.
Bao, X. ORCID: https://orcid.org/0000-0003-0262-1719, Weiner 3rd, J., Meckes, O., Dommisch, H. ORCID: https://orcid.org/0000-0003-1043-2651 and Schaefer, A.S.
Journal of Dental Research 100
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July 2021
Journal of Human Genetics
Xq27.1 palindrome mediated interchromosomal insertion likely causes familial congenital bilateral laryngeal abductor paralysis (Plott syndrome).
Boschann, F. ORCID: https://orcid.org/0000-0001-9410-9290, Moreno, D.A., Mensah, M.A., Sczakiel, H.L., Skipalova, K., Holtgrewe, M. ORCID: https://orcid.org/0000-0002-3051-1763, Mundlos, S. ORCID: https://orcid.org/0000-0002-9788-3166 and Fischer-Zirnsak, B. ORCID: https://orcid.org/0000-0002-1075-7571
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July 2022
Journal of Inherited Metabolic Disease
Expanding the clinical and molecular spectrum of ATP6V1A related metabolic cutis laxa.
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Journal of Investigative Dermatology
Extracellular matrix remodeling in atopic dermatitis harnesses the onset of an asthmatic phenotype and is a potential contributor to the atopic march.
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Journal of Medical Genetics
Biallelic truncating variants in ATP9A cause a novel neurodevelopmental disorder involving postnatal microcephaly and failure to thrive.
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Journal of Medical Virology
Comparable CD8(+) T-cell responses to SARS-CoV-2 vaccination in single-cell transcriptomics of recently allogeneic transplanted patients and healthy individuals.
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Journal of Molecular Diagnostics
Multiplexed quantification of four neuroblastoma DNA targets in a single droplet digital PCR reaction.
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Journal of Neuroinflammation
Spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer’s disease mouse model.
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Journal of the American Medical Informatics Association
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Journal of the American Society of Nephrology
Inflammation in children with chronic kidney disease linked to gut dysbiosis and metabolite imbalance.
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Leukemia
Frequent ZNF217 mutations lead to transcriptional deregulation of interferon signal transduction via altered chromatin accessibility in B cell lymphoma.
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Med
Diagnosing recipient- vs. donor-derived posttransplant myelodysplastic neoplasm via targeted single-cell mutational profiling.
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Metabolites
Modified protocol of harvesting, extraction, and normalization approaches for gas chromatography mass spectrometry-based metabolomics analysis of adherent cells grown under high fetal calf serum conditions.
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WiPP: workflow for improved peak picking for gas chromatography-mass spectrometry (GC-MS) data.
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Molecular Cell
Protein synthesis in the developing neocortex at near-atomic resolution reveals Ebp1-mediated neuronal proteostasis at the 60S tunnel exit.
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Molecular Therapy
EBAG9-silencing exerts an immune checkpoint function without aggravating adverse effects.
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NPJ Biofilms and Microbiomes
Gut microbiota dysbiosis is associated with altered tryptophan metabolism and dysregulated inflammatory response in COVID-19.
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Nature
Non-redundant functions of group 2 innate lymphoid cells.
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Oncogene
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Bischoff, P. ORCID: https://orcid.org/0000-0002-4442-7116, Trinks, A. ORCID: https://orcid.org/0000-0001-9983-1506, Obermayer, B. ORCID: https://orcid.org/0000-0002-9116-630X, Pett, J.P. ORCID: https://orcid.org/0000-0002-5249-444X, Wiederspahn, J. ORCID: https://orcid.org/0000-0003-0117-9754, Uhlitz, F., Liang, X., Lehmann, A., Jurmeister, P., Elsner, A., Dziodzio, T., Rückert, J.C., Neudecker, J., Falk, C., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Sers, C. ORCID: https://orcid.org/0000-0002-6219-1514, Morkel, M. ORCID: https://orcid.org/0000-0002-2553-9999, Horst, D., Blüthgen, N. ORCID: https://orcid.org/0000-0002-0171-7447 and Klauschen, F.
Oncogene 40
: 6748–6758.
16 December 2021
PLoS Computational Biology
Neuroblastoma signalling models unveil combination therapies targeting feedback-mediated resistance.
Dorel, M. ORCID: https://orcid.org/0000-0002-1663-2075, Klinger, B. ORCID: https://orcid.org/0000-0003-0242-1506, Mari, T. ORCID: https://orcid.org/0000-0001-6011-9386, Toedling, J. ORCID: https://orcid.org/0000-0003-1471-1295, Blanc, E. ORCID: https://orcid.org/0000-0002-4369-0254, Messerschmidt, C. ORCID: https://orcid.org/0000-0001-8632-656X, Nadler-Holly, M., Ziehm, M. ORCID: https://orcid.org/0000-0001-7074-4054, Sieber, A. ORCID: https://orcid.org/0000-0001-6588-8547, Hertwig, F. ORCID: https://orcid.org/0000-0003-4784-6516, Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Eggert, A., Schulte, J.H. ORCID: https://orcid.org/0000-0003-0671-1201, Selbach, M. ORCID: https://orcid.org/0000-0003-2454-8751 and Blüthgen, N. ORCID: https://orcid.org/0000-0002-0171-7447
PLoS Computational Biology 17
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4 November 2021
PLoS Genetics
The pleiotropic functions of Pri smORF peptides synchronize leg development regulators.
Markus, D., Pelletier, A. ORCID: https://orcid.org/0000-0002-7458-4964, Boube, M. ORCID: https://orcid.org/0000-0002-4444-2519, Port, F., Boutros, M. ORCID: https://orcid.org/0000-0002-9458-817X, Payre, F., Obermayer, B. ORCID: https://orcid.org/0000-0002-9116-630X and Zanet, J. ORCID: https://orcid.org/0000-0003-4649-4643
PLoS Genetics 19
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30 October 2023
Adipose tissue ATGL modifies the cardiac lipidome in pressure-overload-induced left ventricular failure.
Salatzki, J., Foryst-Ludwig, A., Bentele, K., Blumrich, A., Smeir, E., Ban, Z., Brix, S., Grune, J., Beyhoff, N., Klopfleisch, R., Dunst, S., Surma, M.A., Klose, C., Rothe, M. ORCID: https://orcid.org/0000-0002-6813-4705, Heinzel, F.R., Krannich, A. ORCID: https://orcid.org/0000-0002-4025-6495, Kershaw, E.E., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Schulze, P.C., Marx, N. and Kintscher, U.
PLoS Genetics 14
(1): e1007171.
10 January 2018
PLoS ONE
State-of-the-art analytical methods of viral infections in human lung organoids.
Baumgardt, M. ORCID: https://orcid.org/0000-0003-2077-3716, Hülsemann, M., Löwa, A., Fatykhova, D., Hoffmann, K., Kessler, M., Mieth, M., Hellwig, K., Frey, D., Langenhagen, A., Voss, A., Obermayer, B. ORCID: https://orcid.org/0000-0002-9116-630X, Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Dökel, S., Gruber, A.D., Tölch, U., Hippenstiel, S., Hocke, A.C. and Hönzke, K. ORCID: https://orcid.org/0000-0003-0826-2825
PLoS ONE 17
(12): e0276115.
20 December 2022
PLoS Pathogens
Pharmacological inhibition of bromodomain and extra-terminal proteins induces an NRF-2-mediated antiviral state that is subverted by SARS-CoV-2 infection.
Mhlekude, B. ORCID: https://orcid.org/0000-0003-3696-2482, Postmus, D., Stenzel, S., Weiner, J. ORCID: https://orcid.org/0000-0003-1438-7819, Jansen, J., Zapatero-Belinchón, F.J., Olmer, R., Richter, A., Heinze, J., Heinemann, N., Mühlemann, B., Schroeder, S., Jones, T.C., Müller, M.A., Drosten, C., Pich, A., Thiel, V., Martin, U., Niemeyer, D., Gerold, G., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632 and Goffinet, C. ORCID: https://orcid.org/0000-0002-3959-004X
PLoS Pathogens 19
(9): e1011657.
25 September 2023
PeerJ
SCelVis: exploratory single cell data analysis on the desktop and in the cloud.
Obermayer, B. ORCID: https://orcid.org/0000-0002-9116-630X, Holtgrewe, M. ORCID: https://orcid.org/0000-0002-3051-1763, Nieminen, M. ORCID: https://orcid.org/0000-0002-4180-8810, Messerschmidt, C. ORCID: https://orcid.org/0000-0001-8632-656X and Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632
PeerJ 8
: e8607.
19 February 2020
Proceedings of the National Academy of Sciences of the United States of America
IL-33 controls IL-22-dependent antibacterial defense by modulating the microbiota.
Röwekamp, I., Maschirow, L. ORCID: https://orcid.org/0000-0002-7727-2544, Rabes, A., Fiocca Vernengo, F., Hamann, L. ORCID: https://orcid.org/0000-0003-4719-2583, Heinz, G.A. ORCID: https://orcid.org/0000-0002-9330-3689, Mashreghi, M.F. ORCID: https://orcid.org/0000-0002-8015-6907, Caesar, S., Milek, M. ORCID: https://orcid.org/0000-0002-0803-8439, Fagundes Fonseca, A.C. ORCID: https://orcid.org/0009-0003-9027-8136, Wienhold, S.M., Nouailles, G. ORCID: https://orcid.org/0000-0003-1973-3119, Yao, L. ORCID: https://orcid.org/0000-0002-0482-9604, Mousavi, S., Bruder, D. ORCID: https://orcid.org/0000-0003-3066-189X, Boehme, J.D. ORCID: https://orcid.org/0000-0002-6257-0952, Puzianowska-Kuznicka, M. ORCID: https://orcid.org/0000-0001-5295-3848, Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Witzenrath, M., Löhning, M. ORCID: https://orcid.org/0000-0001-6382-7281, Klose, C.S.N., Heimesaat, M.M. ORCID: https://orcid.org/0000-0001-6399-651X, Diefenbach, A. ORCID: https://orcid.org/0000-0002-9176-9530 and Opitz, B. ORCID: https://orcid.org/0000-0003-1276-836X
Proceedings of the National Academy of Sciences of the United States of America 121
(22): e2310864121.
28 May 2024
Mouse models of human multiple myeloma subgroups.
Winkler, W. ORCID: https://orcid.org/0000-0001-8807-9259, Farré Díaz, C. ORCID: https://orcid.org/0000-0003-4306-2108, Blanc, E. ORCID: https://orcid.org/0000-0002-4369-0254, Napieczynska, H. ORCID: https://orcid.org/0000-0001-5091-1185, Langner, P., Werner, M. ORCID: https://orcid.org/0000-0003-1200-807X, Walter, B. ORCID: https://orcid.org/0000-0002-0844-5958, Wollert-Wulf, B. ORCID: https://orcid.org/0009-0000-0257-4049, Yasuda, T. ORCID: https://orcid.org/0000-0001-9997-6852, Heuser, A. ORCID: https://orcid.org/0000-0002-3334-960X, Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Mathas, S. ORCID: https://orcid.org/0000-0001-9626-1413, Anagnostopoulos, I., Rosenwald, A., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Janz, M. ORCID: https://orcid.org/0000-0002-1127-0044
Proceedings of the National Academy of Sciences of the United States of America 120
(10): e2219439120.
7 March 2023
Research Square
Cerebral small vessel disease may not critically influence familial Parkinson’s disease.
Marhat, B., Bimala, M., Foddis, M., Holtgrewe, M. ORCID: https://orcid.org/0000-0002-3051-1763, Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Bras, J., Guerreiro, R., Kola, V., Schmitt, H.M., Endres, M. and Sassi, C.
Research Square
: rs.3.rs-4518069.
26 June 2024
Science Advances
Adolescence is a sensitive period for prefrontal microglia to act on cognitive development.
Schalbetter, S.M. ORCID: https://orcid.org/0000-0002-6432-1933, von Arx, A.S., Cruz-Ochoa, N. ORCID: https://orcid.org/0000-0002-2740-8044, Dawson, K. ORCID: https://orcid.org/0000-0002-3531-7476, Ivanov, A. ORCID: https://orcid.org/0000-0002-4824-1925, Mueller, F.S., Lin, H.Y. ORCID: https://orcid.org/0000-0002-7294-3652, Amport, R., Mildenberger, W., Mattei, D. ORCID: https://orcid.org/0000-0001-6221-9321, Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Földy, C., Greter, M. ORCID: https://orcid.org/0000-0002-7220-5369, Notter, T. and Meyer, U. ORCID: https://orcid.org/0000-0001-7244-0345
Science Advances 8
(9): eabi6672.
4 March 2022
Science Immunology
C/EBPβ regulates lipid metabolism and Pparg isoform 2 expression in alveolar macrophages.
Dörr, D. ORCID: https://orcid.org/0000-0001-8575-7560, Obermayer, B. ORCID: https://orcid.org/0000-0002-9116-630X, Weiner, J.M. ORCID: https://orcid.org/0000-0003-1438-7819, Zimmermann, K., Anania, C. ORCID: https://orcid.org/0000-0003-1549-4157, Wagner, L.K., Lyras, E.M. ORCID: https://orcid.org/0000-0003-3269-0854, Sapozhnikova, V., Lara-Astiaso, D. ORCID: https://orcid.org/0000-0001-8686-4675, Prósper, F. ORCID: https://orcid.org/0000-0001-6115-8790, Lang, R., Lupiáñez, D.G. ORCID: https://orcid.org/0000-0002-3165-036X, Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Höpken, U.E. ORCID: https://orcid.org/0000-0002-0776-4893, Leutz, A. ORCID: https://orcid.org/0000-0001-8259-927X and Mildner, A. ORCID: https://orcid.org/0000-0002-2019-8427
Science Immunology 7
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September 2022
Science Translational Medicine
Increased β(2)-adrenergic signaling promotes fracture healing through callus neovascularization in mice.
Jahn, D. ORCID: https://orcid.org/0000-0001-8912-5851, Knapstein, P.R. ORCID: https://orcid.org/0000-0002-4039-6674, Otto, E., Köhli, P. ORCID: https://orcid.org/0000-0001-7473-6553, Sevecke, J. ORCID: https://orcid.org/0009-0001-1016-3482, Graef, F. ORCID: https://orcid.org/0000-0002-0435-9059, Graffmann, C. ORCID: https://orcid.org/0009-0004-2423-8141, Fuchs, M., Jiang, S. ORCID: https://orcid.org/0000-0002-1545-2152, Rickert, M., Erdmann, C., Appelt, J. ORCID: https://orcid.org/0000-0001-6351-9959, Revend, L., Küttner, Q., Witte, J., Rahmani, A., Duda, G. ORCID: https://orcid.org/0000-0001-7605-3908, Xie, W. ORCID: https://orcid.org/0000-0002-1404-793X, Donat, A. ORCID: https://orcid.org/0000-0003-3069-0199, Schinke, T., Ivanov, A. ORCID: https://orcid.org/0000-0002-4824-1925, Tchouto, M.N., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Frosch, K.H., Baranowsky, A. ORCID: https://orcid.org/0009-0007-3883-646X, Tsitsilonis, S. and Keller, J. ORCID: https://orcid.org/0000-0002-8925-7288
Science Translational Medicine 16
(743): eadk9129.
17 April 2024
Early-set POMC methylation variability is accompanied by increased risk for obesity and is addressable by MC4R agonist treatment.
Lechner, L. ORCID: https://orcid.org/0000-0002-9318-6857, Opitz, R. ORCID: https://orcid.org/0000-0003-3143-0997, Silver, M.J. ORCID: https://orcid.org/0000-0002-3852-9677, Krabusch, P.M., Prentice, A.M. ORCID: https://orcid.org/0000-0001-5389-451X, Field, M.S., Stachelscheid, H. ORCID: https://orcid.org/0000-0002-9283-4605, Leitão, E. ORCID: https://orcid.org/0000-0001-5051-9714, Schröder, C., Fernandez Vallone, V. ORCID: https://orcid.org/0000-0003-3875-9170, Horsthemke, B., Jöckel, K.H. ORCID: https://orcid.org/0000-0002-1987-0255, Schmidt, B., Nöthen, M.M. ORCID: https://orcid.org/0000-0002-8770-2464, Hoffmann, P. ORCID: https://orcid.org/0000-0002-6573-983X, Herms, S. ORCID: https://orcid.org/0000-0002-2786-8200, Kleyn, P.W. ORCID: https://orcid.org/0000-0002-6249-8196, Megges, M. ORCID: https://orcid.org/0000-0001-6537-0975, Blume-Peytavi, U. ORCID: https://orcid.org/0000-0003-3528-3752, Weiss, K. ORCID: https://orcid.org/0000-0002-0658-8074, Mai, K., Blankenstein, O. ORCID: https://orcid.org/0000-0003-1803-5589, Obermayer, B. ORCID: https://orcid.org/0000-0002-9116-630X, Wiegand, S. ORCID: https://orcid.org/0000-0001-8341-9533 and Kühnen, P. ORCID: https://orcid.org/0000-0003-0211-176X
Science Translational Medicine 15
(705): eadg1659.
July 2023
Scientific Reports
Transcriptomic comparison of primary human lung cells with lung tissue samples and the human A549 lung cell line highlights cell type specific responses during infections with influenza A virus.
Bertrams, W., Hönzke, K., Obermayer, B. ORCID: https://orcid.org/0000-0002-9116-630X, Tönnies, M., Bauer, T.T., Schneider, P., Neudecker, J., Rückert, J.C., Stiewe, T., Nist, A., Eggeling, S., Suttorp, N., Wolff, T., Hippenstiel, S., Schmeck, B. and Hocke, A.C.
Scientific Reports 12
(1): 20608.
29 November 2022
PHACTR1 genetic variability is not critical in small vessel ischemic disease patients and PcomA recruitment in C57BL/6J mice.
Messerschmidt, C. ORCID: https://orcid.org/0000-0001-8632-656X, Foddis, M., Blumenau, S., Müller, S., Bentele, K., Holtgrewe, M. ORCID: https://orcid.org/0000-0002-3051-1763, Kun-Rodrigues, C., Alonso, I., do Carmo Macario, M., Morgadinho, A.S., Velon, A.G., Santo, G., Santana, I., Mönkäre, S., Kuuluvainen, L., Schleutker, J., Pöyhönen, M., Myllykangas, L., Senatore, A., Berchtold, D., Winek, K., Meisel, A., Pavlovic, A., Kostic, V., Dobricic, V., Lohmann, E., Hanagasi, H., Guven, G., Bilgic, B., Bras, J., Guerreiro, R., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Dirnagl, U. and Sassi, C.
Scientific Reports 11
(1): 6072.
16 March 2021
Investigating APOE, APP-Aβ metabolism genes and Alzheimer's disease GWAS hits in brain small vessel ischemic disease.
Blumenau, S., Foddis, M., Müller, S., Holtgrewe, M. ORCID: https://orcid.org/0000-0002-3051-1763, Bentele, K., Berchtold, D., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Dirnagl, U. and Sassi, C.
Scientific Reports 10
(1): 7103.
28 April 2020
Multisite de novo mutations in human offspring after paternal exposure to ionizing radiation.
Holtgrewe, M. ORCID: https://orcid.org/0000-0002-3051-1763, Knaus, A., Hildebrand, G., Pantel, J.T., de los Santos, M.R. ORCID: https://orcid.org/0000-0002-2126-7658, Neveling, K., Goldmann, J., Schubach, M., Jäger, M., Coutelier, M. ORCID: https://orcid.org/0000-0002-0261-7210, Mundlos, S., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Sperling, K. and Krawitz, P.M. ORCID: https://orcid.org/0000-0002-3194-8625
Scientific Reports 8
(1): 14611.
2 October 2018
Stem Cell Research
Generation of iPSC lines with SLC16A2:G401R or SLC16A2 knock out.
Ludwik, K.A. ORCID: https://orcid.org/0000-0002-9436-7270, Opitz, R. ORCID: https://orcid.org/0000-0003-3143-0997, Jyrch, S., Megges, M. ORCID: https://orcid.org/0000-0001-6537-0975, Weiner, J. ORCID: https://orcid.org/0000-0003-1438-7819, Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Kühnen, P. and Stachelscheid, H.
Stem Cell Research 73
: 103256.
21 November 2023
Thyroid
Partial resistance to thyroid hormone-induced tachycardia and cardiac hypertrophy in mice lacking thyroid hormone receptor β.
Dore, R. ORCID: https://orcid.org/0000-0001-5988-9885, Sentis, S.C., Johann, K. ORCID: https://orcid.org/0000-0002-5089-7237, Lopez-Alcantara, N., Resch, J., Chandrasekar, A., Müller-Fielitz, H. ORCID: https://orcid.org/0000-0003-2815-4426, Moeller, L.C., Fuehrer, D., Schwaninger, M., Obermayer, B. ORCID: https://orcid.org/0000-0002-9116-630X, Opitz, R. ORCID: https://orcid.org/0000-0003-3143-0997 and Mittag, J. ORCID: https://orcid.org/0000-0001-7778-5158
Thyroid 34
(6): 796-805.
June 2024
Toxins
A colonic organoid model challenged with the large toxins of Clostridioides difficile TcdA and TcdB exhibit deregulated tight junction proteins.
Schneemann, M. ORCID: https://orcid.org/0000-0002-7900-1879, Heils, L. ORCID: https://orcid.org/0000-0002-3808-0822, Moos, V. ORCID: https://orcid.org/0000-0002-9558-7291, Weiß, F., Krug, S.M. ORCID: https://orcid.org/0000-0002-1293-2484, Weiner, J. ORCID: https://orcid.org/0000-0003-1438-7819, Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Gerhard, R. ORCID: https://orcid.org/0000-0002-9380-3640, Schulzke, J.D. ORCID: https://orcid.org/0000-0001-9947-5521 and Bücker, R. ORCID: https://orcid.org/0000-0002-1345-4146
Toxins 15
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4 November 2023
Translational Psychiatry
Maternal immune activation results in complex microglial transcriptome signature in the adult offspring that is reversed by minocycline treatment.
Mattei, D. ORCID: https://orcid.org/0000-0001-6221-9321, Ivanov, A. ORCID: https://orcid.org/0000-0002-4824-1925, Ferrai, C. ORCID: https://orcid.org/0000-0002-8088-2757, Jordan, P., Guneykaya, D. ORCID: https://orcid.org/0000-0001-5723-0737, Buonfiglioli, A. ORCID: https://orcid.org/0000-0002-5550-9360, Schaafsma, W., Przanowski, P., Deuther-Conrad, W., Brust, P., Hesse, S., Patt, M., Sabri, O., Ross, T.L., Eggen, B.J.L., Boddeke, E.W.G.M., Kaminska, B., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Pombo, A. ORCID: https://orcid.org/0000-0002-7493-6288, Kettenmann, H. ORCID: https://orcid.org/0000-0001-8208-0291 and Wolf, S.A. ORCID: https://orcid.org/0000-0003-0922-8418
Translational Psychiatry 7
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9 May 2017
Zenodo
Mutational topography reflects clinical neuroblastoma heterogeneity.
Rodriguez-Fos, Elias ORCID: https://orcid.org/0000-0002-2555-0178, Planas-Fèlix, Mercè, Burkert, Martin ORCID: https://orcid.org/0000-0002-6721-9985, Puiggròs, Montserrat, Toedling, Joern, Thiessen, Nina, Blanc, Eric ORCID: https://orcid.org/0000-0002-4369-0254, Szymansky, Annabell ORCID: https://orcid.org/0000-0003-4797-4526, Hertwig, Falk ORCID: https://orcid.org/0000-0003-4784-6516, Ishaque, Naveed ORCID: https://orcid.org/0000-0002-8426-901X, Beule, Dieter ORCID: https://orcid.org/0000-0002-3284-0632, Torrents, David, Eggert, Angelika, Koche, Richard P., Schwarz, Roland F. ORCID: https://orcid.org/0000-0001-9155-4268, Haase, Kerstin ORCID: https://orcid.org/0000-0002-0944-5618, Schulte, Johannes H. ORCID: https://orcid.org/0000-0003-0671-1201 and Henssen, Anton G. ORCID: https://orcid.org/0000-0003-1534-778X
[Dataset]
27 April 2023
arXiv
Portability of scientific workflows in NGS data analysis: a case study.
Schiefer, C., Bux, M., Brandt, J., Messerschmidt, C. ORCID: https://orcid.org/0000-0001-8632-656X, Reinert, K., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632 and Leser, U.
arXiv
: 2006.03104.
4 June 2020
bioRxiv
mehari: high-performance, strict HGVS-first variant effect prediction.
Hartmann, Till ORCID: https://orcid.org/0000-0002-6993-347X, Zhao, Max ORCID: https://orcid.org/0000-0001-7259-1901, Beule, Dieter ORCID: https://orcid.org/0000-0002-3284-0632 and Holtgrewe, Manuel ORCID: https://orcid.org/0000-0002-3051-1763
bioRxiv
: 2026.05.12.724271.
14 May 2026
Endothelial YAP/TAZ rewiring under cardiometabolic stress drives sex-divergent vascular remodeling in heart failure with preserved ejection fraction.
Klaus-Bergmann, Alexandra ORCID: https://orcid.org/0000-0002-1164-3322, Sievers, Laura Katharina, Versnjak, Jakob, Koch, Katharina, Nawara, Tomasz ORCID: https://orcid.org/0000-0002-4801-4095, Bartels-Klein, Eireen, Popp, Oliver ORCID: https://orcid.org/0000-0001-6240-4666, Weiner 3rd, January ORCID: https://orcid.org/0000-0003-1438-7819, Meier, Katja, Hollfinger, Irene ORCID: https://orcid.org/0000-0002-6233-8395, Kamer, Ilona, Taube, Martin, Heuser, Arnd ORCID: https://orcid.org/0000-0002-3334-960X, Borodina, Tatiana ORCID: https://orcid.org/0000-0002-6978-016X, Beule, Dieter ORCID: https://orcid.org/0000-0002-3284-0632, Potente, Michael ORCID: https://orcid.org/0000-0002-5689-0036, Landmesser, Ulf ORCID: https://orcid.org/0000-0002-0214-3203, Mertins, Philipp ORCID: https://orcid.org/0000-0002-2245-528X, Kelm, Marcus, Muller, Dominik N. ORCID: https://orcid.org/0000-0003-3650-5644 and Gerhardt, Holger ORCID: https://orcid.org/0000-0002-3030-0384
bioRxiv
: 2026.05.07.723127.
13 May 2026
StemCNV-check: a pipeline for human pluripotent stem cell (hPSC) genomic integrity control using SNP array data and copy number variant scoring.
von Kuegelgen, Nicolai ORCID: https://orcid.org/0000-0001-8116-9032, Fernandez Vallone, Valeria, Ludwik, Katarzyna A. ORCID: https://orcid.org/0000-0002-9436-7270, Babaeva, Mariia, Diecke, Sebastian ORCID: https://orcid.org/0000-0002-5219-5992, Beule, Dieter ORCID: https://orcid.org/0000-0002-3284-0632 and Stachelscheid, Harald
bioRxiv
: 2025.12.01.691615.
3 December 2025
Formation of amyloid-like HTTex1 aggregates in neurons, downregulation of synaptic proteins and early mortality of Huntington's disease flies are causally linked.
Ast, A. ORCID: https://orcid.org/0000-0002-2312-1257, Roth, L., Brusendorf, L., Schindler, F. ORCID: https://orcid.org/0000-0002-3320-8284, Ammar, O.W.M. ORCID: https://orcid.org/0009-0003-5341-4434, Berberich, S., Edel, J., Bonsor, M., Georgii, E., Hänig, C. ORCID: https://orcid.org/0000-0003-1973-7646, Langnick, C., Ivanov, A. ORCID: https://orcid.org/0000-0002-4824-1925, Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Piraud, M., Kunz, S. ORCID: https://orcid.org/0000-0002-0131-3506, Popp, O. ORCID: https://orcid.org/0000-0001-6240-4666, Mertins, P. ORCID: https://orcid.org/0000-0002-2245-528X, Petzoldt, A.G. and Wanker, E.E. ORCID: https://orcid.org/0000-0001-8072-1630
bioRxiv
: 2025.02.06.636778.
7 February 2025
Reporter-based screening identifies RAS-RAF mutations as drivers of resistance to active-state RAS inhibition in colorectal cancer.
Aust, O., Blanc, E. ORCID: https://orcid.org/0000-0002-4369-0254, Lüthen, M. ORCID: https://orcid.org/0000-0001-5557-6419, Hollek, V. ORCID: https://orcid.org/0000-0001-9768-5568, Astaburuaga-García, R. ORCID: https://orcid.org/0000-0003-1179-4080, Klinger, B. ORCID: https://orcid.org/0000-0003-0242-1506, Trinks, A. ORCID: https://orcid.org/0000-0001-9983-1506, Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Papke, B. ORCID: https://orcid.org/0000-0001-8156-7508, Horst, D. ORCID: https://orcid.org/0000-0003-4755-5743, Blüthgen, N. ORCID: https://orcid.org/0000-0002-0171-7447, Sers, C. ORCID: https://orcid.org/0000-0002-6219-1514, Der, C.J. ORCID: https://orcid.org/0000-0002-7751-2747 and Morkel, M. ORCID: https://orcid.org/0000-0002-2553-9999
bioRxiv
: 2024.07.01.601542v2.
12 July 2024
Ide copy number variant does not influence lesion size and mortality in two C57BL/6J mouse models of cerebrovascular ischemia nor in human cerebrovascular disease. An exploratory study.
Foddis, M., Blumenau, S., Mueller, S., Messerschmidt, C. ORCID: https://orcid.org/0000-0001-8632-656X, Rocca, C., Pagnamenta, A.T., Winek, K., Endres, M., Meisel, A., Tucci, A., Bras, J., Guerreiro, R., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Dirnagl, U. and Sassi, C.
bioRxiv
: 2024.05.15.593342.
16 May 2024
Osteopontin in colitis-associated carcinoma.
Manna, S., Sehn, M., Cardoso da Silva, D., Wiese, J.J., Heldt, C., Plumbom, I. ORCID: https://orcid.org/0009-0006-3720-3700, Conrad, T. ORCID: https://orcid.org/0000-0001-5618-6295, Husemann, C.C., Kleo, K., Derêzanin, L., Dony, V., Farahani, S.K., Weiss, F., Branchi, F., Kühl, A.A., Schallenberg, S., Weiner, J. ORCID: https://orcid.org/0000-0003-1438-7819, Elezkurtaj, S., Weixler, B., Gröne, J., Siegmund, B., Hummel, M. and Schumann, M.
bioRxiv
: 2023.12.15.571952.
16 December 2023
A kinetic error filtering mechanism for enzyme-free copying of nucleic acid sequences.
Göppel, Tobias ORCID: https://orcid.org/0000-0001-8078-1262, Obermayer, Benedikt ORCID: https://orcid.org/0000-0002-9116-630X, Chen, Irene A. ORCID: https://orcid.org/0000-0001-6040-7927 and Gerland, Ulrich ORCID: https://orcid.org/0000-0002-0859-6422
bioRxiv
: 2021.08.06.455386.
9 August 2021
Emergence of robust nucleosome patterns from an interplay of positioning mechanisms.
Nuebler, J., Wolff, M., Obermayer, B. ORCID: https://orcid.org/0000-0002-9116-630X, Mobius, W. and Gerland, U.
bioRxiv
: 431445.
1 October 2018
iScience
Copy-number dosage regulates telomere maintenance and disease-associated pathways in neuroblastoma.
Burkert, M. ORCID: https://orcid.org/0000-0002-6721-9985, Blanc, E. ORCID: https://orcid.org/0000-0002-4369-0254, Thiessen, N., Weber, C., Toedling, J. ORCID: https://orcid.org/0000-0003-1471-1295, Monti, R. ORCID: https://orcid.org/0000-0002-6354-8319, Dombrowe, V.M. ORCID: https://orcid.org/0000-0002-1466-1518, de Biase, M.S. ORCID: https://orcid.org/0000-0003-0383-5161, Kaufmann, T.L. ORCID: https://orcid.org/0000-0003-4374-1338, Haase, K. ORCID: https://orcid.org/0000-0002-0944-5618, Waszak, S.M., Eggert, A., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Schulte, J.H. ORCID: https://orcid.org/0000-0003-0671-1201, Ohler, U. ORCID: https://orcid.org/0000-0002-0881-3116 and Schwarz, R.F. ORCID: https://orcid.org/0000-0001-9155-4268
iScience 27
(10): 110918.
18 October 2024
Soluble ACE2 correlates with severe COVID-19 and can impair antibody responses.
Lebedin, M. ORCID: https://orcid.org/0000-0002-3877-7195, Ratswohl, C. ORCID: https://orcid.org/0000-0001-5413-0730, Garg, A., Schips, M., Vazquez Garcia, C. ORCID: https://orcid.org/0000-0003-4583-7616, Spatt, L., Thibeault, C., Obermayer, B. ORCID: https://orcid.org/0000-0002-9116-630X, Weiner, J. ORCID: https://orcid.org/0000-0003-1438-7819, Moreno Velásquez, I. ORCID: https://orcid.org/0000-0001-6058-8983, Gerhard, C. ORCID: https://orcid.org/0000-0001-6956-7249, Stubbemann, P., Hanitsch, L.G., Pischon, T. ORCID: https://orcid.org/0000-0003-1568-767X, Witzenrath, M., Sander, L.E., Kurth, F., Meyer-Hermann, M. and de la Rosa, K. ORCID: https://orcid.org/0000-0003-4809-3157
iScience 27
(3): 109330.
15 March 2024
Depletion of cardiac cardiolipin synthase alters systolic and diastolic function.
Smeir, E., Leberer, S. ORCID: https://orcid.org/0000-0001-9763-6694, Blumrich, A. ORCID: https://orcid.org/0000-0003-4720-8717, Vogler, G., Vasiliades, A., Dresen, S., Jaeger, C. ORCID: https://orcid.org/0000-0003-2192-1792, Gloaguen, Y. ORCID: https://orcid.org/0000-0003-0493-8592, Klose, C., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Schulze, P.C., Bodmer, R., Foryst-Ludwig, A. and Kintscher, U.
iScience 24
(11): 103314.
19 November 2021
Transcriptomic profiling of SARS-CoV-2 infected human cell lines identifies HSP90 as target for COVID-19 therapy.
Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Mösbauer, K., Franke, V. ORCID: https://orcid.org/0000-0003-3606-6792, Diag, A., Gottula, L.T., Arsiè, R. ORCID: https://orcid.org/0000-0002-7869-7624, Klironomos, F., Koppstein, D. ORCID: https://orcid.org/0000-0002-8618-7237, Hönzke, K., Ayoub, S. ORCID: https://orcid.org/0000-0001-5043-8922, Buccitelli, C. ORCID: https://orcid.org/0000-0002-2637-2131, Hoffmann, K., Richter, A., Legnini, I. ORCID: https://orcid.org/0000-0002-8984-5215, Ivanov, A. ORCID: https://orcid.org/0000-0002-4824-1925, Mari, T. ORCID: https://orcid.org/0000-0001-6011-9386, Del Giudice, S. ORCID: https://orcid.org/0000-0003-0194-3767, Papies, J., Praktiknjo, S. ORCID: https://orcid.org/0000-0002-0186-5271, Meyer, T.F., Müller, M.A., Niemeyer, D., Hocke, A., Selbach, M. ORCID: https://orcid.org/0000-0003-2454-8751, Akalin, A. ORCID: https://orcid.org/0000-0002-0468-0117, Rajewsky, N. ORCID: https://orcid.org/0000-0002-4785-4332, Drosten, C. and Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734
iScience 24
(3): 102151.
19 March 2021
medRxiv
Cytokines as potential novel therapeutic targets in severe inflammatory cardiomyopathy.
Suwalski, P. ORCID: https://orcid.org/0000-0002-2678-2595, Golpour, A., Weiner, J. ORCID: https://orcid.org/0000-0003-1438-7819, Musigk, N., Balzer, F., Giesa, N., Amr, A., Trebing, J., Sedaghat, F., Meder, B., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Landmesser, U. and Heidecker, B. ORCID: https://orcid.org/0000-0002-3811-7920
medRxiv
: 2023.07.27.23293253.
4 August 2023
This list was generated on Wed Jun 17 14:00:04 2026 UTC.
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