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Antigen receptor-engineered Tregs inhibit CNS autoimmunity in cell therapy using non-redundant immune mechanisms in mice.
Pohar, J. and O'Connor, R. and Manfroi, B. and Behi, M.E. and Jouneau, L. and Boudinot, P. and Bunse, M. and Uckert, W. and Luka, M. and Ménager, M. and Liblau, R. and Anderton, S.M. and Fillatreau, S.
European Journal of Immunology 52 (8): 1335-1349. August 2022

TCR and CAR engineering of primary human T cells.
Edes, I. and Clauss, J. and Stahn, R. and Sada Japp, A. and Lorenz, F.K.M.
Methods in Molecular Biology 2521 (3): 85-93. 23 June 2022


Gene therapy "Made in Germany": a historical perspective, analysis of the status quo, and recommendations for action by the German Society for Gene Therapy.
Büning, H. and Fehse, B. and Ivics, Z. and Kochanek, S. and Koehl, U. and Kupatt, C. and Mussolino, C. and Nettelbeck, D.M. and Schambach, A. and Uckert, W. and Wagner, E. and Cathomen, T.
Human Gene Therapy 32 (19-20): 987-996. 18 October 2021

Generation of Epstein-Barr virus antigen-specific T cell receptors recognizing immunodominant epitopes of LMP1, LMP2A, and EBNA3C for immunotherapy.
Dudaniec, K. and Westendorf, K. and Nössner, E. and Uckert, W.
Human Gene Therapy 32 (17-18): 919-935. 21 September 2021

Characterization and modulation of anti- αβTCR antibodies and their respective binding sites at the βTCR chain to enrich engineered T cells.
Kierkels, G.J.J. and van Diest, E. and Hernández-López, P. and Scheper, W. and de Bruin, A.C.M. and Frijlink, E. and Aarts-Riemens, T. and van Dooremalen, S.F.J. and Beringer, D.X. and Oostvogels, R. and Kramer, L. and Straetemans, T. and Uckert, W. and Sebestyén, Z. and Kuball, J.
Molecular Therapy - Methods and Clinical Development 22 (10): 388-400. 10 September 2021

CXCR5 CAR-T cells simultaneously target B cell non-Hodgkin's lymphoma and tumor-supportive follicular T helper cells.
Bunse, M. and Pfeilschifter, J. and Bluhm, J. and Zschummel, M. and Joedicke, J.J. and Wirges, A. and Stark, H. and Kretschmer, V. and Chmielewski, M. and Uckert, W. and Abken, H. and Westermann, J. and Rehm, A. and Höpken, U.E.
Nature Communications 12 (1): 240. 11 January 2021


CD8-specific designed ankyrin repeat proteins improve selective gene delivery into human and primate T lymphocytes.
Frank, A.M. and Weidner, T. and Brynza, J. and Uckert, W. and Buchholz, C.J. and Hartmann, J.
Human Gene Therapy 31 (11-12): 679-691. June 2020

ER-aminopeptidase 1 determines the processing and presentation of an immunotherapy-relevant melanoma epitope.
Textoris-Taube, K. and Cammann, C. and Henklein, P. and Topfstedt, E. and Ebstein, F. and Henze, S. and Liepe, J. and Zhao, F. and Schadendorf, D. and Dahlmann, B. and Uckert, W. and Paschen, A. and Mishto, M. and Seifert, U.
European Journal of Immunology 50 (2): 270-283. February 2020


Effective NY-ESO-1-specific MHC II-restricted T cell receptors from antigen-negative hosts enhance tumor regression.
Poncette, L. and Chen, X. and Lorenz, F.K.M. and Blankenstein, T.
Journal of Clinical Investigation 129 (1): 324-335. 2 January 2019

Mapping the MHC class I spliced immunopeptidome of cancer cells.
Liepe, J. and Sidney, J. and Lorenz, F.K.M. and Sette, A. and Mishto, M.
Cancer Immunology Research 7 (1): 62-76. January 2019


CAR T cells with enhanced sensitivity to B cell maturation antigen for the targeting of B cell non-Hodgkin's lymphoma and multiple myeloma.
Bluhm, J. and Kieback, E. and Marino, S.F. and Oden, F. and Westermann, J. and Chmielewski, M. and Abken, H. and Uckert, W. and Höpken, U.E. and Rehm, A.
Molecular Therapy 26 (8): 1906-1920. 1 August 2018

Efficient non-viral T cell engineering by Sleeping Beauty minicircles diminishing DNA toxicity and miRNAs silencing the endogenous TCR.
Clauss, J. and Obenaus, M. and Miskey, C. and Ivics, Z. and Izsvák, Z. and Uckert, W. and Bunse, M.
Human Gene Therapy 29 (5): 569-584. May 2018

Distinguishing features of microglia- and monocyte-derived macrophages after stroke.
Kronenberg, G. and Uhlemann, R. and Richter, N. and Klempin, F. and Wegner, S. and Staerck, L. and Wolf, S. and Uckert, W. and Kettenmann, H. and Endres, M. and Gertz, K.
Acta Neuropathologica 135 (4): 551. April 2018


Unbiased identification of T cell receptors targeting immunodominant peptide-MHC complexes for T cell receptor immunotherapy.
Lorenz, F.K.M. and Ellinger, C. and Kieback, E. and Wilde, S. and Lietz, M. and Schendel, D.J. and Uckert, W.
Human Gene Therapy 28 (12): 1158-1168. 1 December 2017

Isolation and functional characterization of hepatitis B virus-specific T-cell receptors as new tools for experimental and clinical use.
Wisskirchen, K. and Metzger, K. and Schreiber, S. and Asen, T. and Weigand, L. and Dargel, C. and Witter, K. and Kieback, E. and Sprinzl, M.F. and Uckert, W. and Schiemann, M. and Busch, D.H. and Krackhardt, A.M. and Protzer, U.
PLoS ONE 12 (8): e0182936. 8 August 2017

Chimeric PD-1:28 receptor upgrades low-avidity T cells and restores effector function of tumor-infiltrating lymphocytes for adoptive cell therapy.
Schlenker, R. and Olguín-Contreras, L.F. and Leisegang, M. and Schnappinger, J. and Disovic, A. and Rühland, S. and Nelson, P.J. and Leonhardt, H. and Harz, H. and Wilde, S. and Schendel, D.J. and Uckert, W. and Willimsky, G. and Noessner, E.
Cancer Research 77 (13): 3577-3590. 1 July 2017

Tumour ischaemia by interferon-γ resembles physiological blood vessel regression.
Kammertoens, T. and Friese, C. and Arina, A. and Idel, C. and Briesemeister, D. and Rothe, M. and Ivanov, A. and Szymborska, A. and Patone, G. and Kunz, S. and Sommermeyer, D. and Engels, B. and Leisegang, M. and Textor, A. and Fehling, H.J. and Fruttiger, M. and Lohoff, M. and Herrmann, A. and Yu, H. and Weichselbaum, R. and Uckert, W. and Hübner, N. and Gerhardt, H. and Beule, D. and Schreiber, H. and Blankenstein, T.
Nature 545 (7652): 98-102. 4 May 2017

Activation-dependent TRAF3 exon 8 alternative splicing is controlled by CELF2 and hnRNP C binding to an upstream intronic element.
Schultz, A.S. and Preussner, M. and Bunse, M. and Karni, R. and Heyd, F.
Molecular and Cellular Biology 37 (7): e.00488-16. April 2017


Domain-swapped T cell receptors improve the safety of TCR gene therapy.
Bethune, M.T. and Gee, M.H. and Bunse, M. and Lee, M.S. and Gschweng, E.H. and Pagadala, M.S. and Zhou, J. and Cheng, D. and Heath, J.R. and Kohn, D.B. and Kuhns, M.S. and Uckert, W. and Baltimore, D.
eLife 5 : e19095. 8 November 2016

In vivo transduction of primitive mobilized hematopoietic stem cells after intravenous injection of integrating adenovirus vectors.
Richter, M. and Saydaminova, K. and Yumul, R. and Krishnan, R. and Liu, J. and Nagy, E.E. and Singh, M. and Izsvák, Z. and Cattaneo, R. and Uckert, W. and Palmer, D. and Ng, P. and Haworth, K.G. and Kiem, H.P. and Ehrhardt, A. and Papayannopoulou, T. and Lieber, A.
Blood 128 (18): 2206-2217. 3 November 2016

ERK1 as a therapeutic target for dendritic cell vaccination against high-grade gliomas.
Ku, M.C. and Edes, I. and Bendix, I. and Pohlmann, A. and Waiczies, H. and Prozorovski, T. and Günther, M. and Martin, C. and Pagès, G. and Wolf, S.A. and Kettenmann, H. and Uckert, W. and Niendorf, T. and Waiczies, S.
Molecular Cancer Therapeutics 15 (8): 1975-1987. August 2016

Eradication of large solid tumors by gene therapy with a T cell receptor targeting a single cancer-specific point mutation.
Leisegang, M. and Engels, B. and Schreiber, K. and Yew, P.Y. and Kiyotani, K. and Idel, C. and Arina, A. and Duraiswamy, J. and Weichselbaum, R.R. and Uckert, W. and Nakamura, Y. and Schreiber, H.
Clinical Cancer Research 22 (11): 2734-2743. 1 June 2016

Thymus-derived regulatory T cells are positively selected on natural self-antigen through cognate interactions of high functional avidity.
Kieback, E. and Hilgenberg, E. and Stervbo, U. and Lampropoulou, V. and Shen, P. and Bunse, M. and Jaimes, Y. and Boudinot, P. and Radbruch, A. and Klemm, U. and Kühl, A.A. and Liblau, R. and Hoevelmeyer, N. and Anderton, S.M. and Uckert, W. and Fillatreau, S.
Immunity 44 (5): 1114-1126. 17 May 2016

Transgenic antigen-specific, HLA-A*02:01-allo-restricted cytotoxic T cells recognize tumor-associated target antigen STEAP1 with high specificity.
Schirmer, D. and Grünewald, T.G.P. and Klar, R. and Schmidt, O. and Wohlleber, D. and Rubio, R.A. and Uckert, W. and Thiel, U. and Bohne, F. and Busch, D.H. and Krackhardt, A.M. and Burdach, S. and Richter, G.H.S.
OncoImmunology 5 (6): e1175795. 25 April 2016

Proteasomes generate spliced epitopes by two different mechanisms and as efficiently as non-spliced epitopes.
Ebstein, F. and Textoris-Taube, K. and Keller, C. and Golnik, R. and Vigneron, N. and Van den Eynde, B.J. and Schuler-Thurner, B. and Schadendorf, D. and Lorenz, F.K.M. and Uckert, W. and Urban, S. and Lehmann, A. and Albrecht-Koepke, N. and Janek, K. and Henklein, P. and Niewienda, A. and Kloetzel, P.M. and Mishto, M.
Scientific Reports 6 : 24032. 6 April 2016

Targeting human melanoma neoantigens by T cell receptor gene therapy.
Leisegang, M. and Kammertoens, T. and Uckert, W. and Blankenstein, T.
Journal of Clinical Investigation 126 (3): 854-858. 1 March 2016

Genome-wide profiling reveals remarkable parallels between insertion site selection properties of the MLV retrovirus and the piggyBac transposon in primary human CD4(+) T cells.
Gogol-Döring, A. and Ammar, I. and Gupta, S. and Bunse, M. and Miskey, C. and Chen, W. and Uckert, W. and Schulz, T.F. and Izsvák, Z. and Ivics, Z.
Molecular Therapy 24 (3): 592-606. March 2016

Targeting B-cell neoplasia with T-cell receptors recognizing a CD20-derived peptide on patient-specific HLA.
Mensali, N. and Ying, F. and Sheng, V.O.Y. and Yang, W. and Walseng, E. and Kumari, S. and Fallang, L.E. and Kolstad, A. and Uckert, W. and Malmberg, K.J. and Waelchli, S. and Olweus, J.
OncoImmunology 5 (5): e1138199. 18 February 2016


T cells engineered to express a T-cell receptor specific for glypican-3 recognize and kill hepatoma cells in vitro and in mice.
Dargel, C. and Bassani-Sternberg, M. and Hasreiter, J. and Zani, F. and Bockmann, J.H. and Thiele, F. and Bohne, F. and Wisskirchen, K. and Wilde, S. and Sprinzl, M.F. and Schendel, D.J. and Krackhardt, A.M. and Uckert, W. and Wohlleber, D. and Schiemann, M. and Stemmer, K. and Heikenwälder, M. and Busch, D.H. and Richter, G. and Mann, M. and Protzer, U.
Gastroenterology 149 (4): 1042-1052. October 2015

Designer T cells - New possibilities for immunotherapy of cancer [Designer-T-Zellen - neue Möglichkeiten für die Immuntherapie von Krebs].
Leisegang, M. and Uckert, W.
BIOspektrum 21 (4): 402-405. June 2015

Identification of human T-cell receptors with optimal affinity to cancer antigens using antigen-negative humanized mice.
Obenaus, M. and Leitão, C. and Leisegang, M. and Chen, X. and Gavvovidis, I. and van der Bruggen, P. and Uckert, W. and Schendel, D.J. and Blankenstein, T.
Nature Biotechnology 33 (4): 402-407. April 2015

Targeting cancer-specific mutations by T cell receptor gene therapy.
Blankenstein, T. and Leisegang, M. and Uckert, W. and Schreiber, H.
Current Opinion in Immunology 33 : 112-119. April 2015

Codon optimization of the human papillomavirus E7 oncogene induces a CD8(+) T cell response to a cryptic epitope not harbored by wild-type E7.
Lorenz, F.K.M. and Wilde, S. and Voigt, K. and Kieback, E. and Mosetter, B. and Schendel, D.J. and Uckert, W.
PLoS ONE 10 (3): e0121633. 23 March 2015

CD8 T cell tolerance to a tumor-associated self-antigen is reversed by CD4 T cells engineered to express the same T cell receptor.
Ghorashian, S. and Veliça, P. and Chua, I. and McNicol, A. and Carpenter, B. and Holler, A. and Nicholson, E. and Ahmadi, M. and Zech, M. and Xue, S. and Uckert, W. and Morris, E. and Chakraverty, R. and Stauss, H.J.
Journal of Immunology 194 (3): 1080-1089. 1 February 2015

IFN-γ regulates CD8(+) memory T cell differentiation and survival in response to weak, but not strong, TCR signals.
Stoycheva, D. and Deiser, K. and Stärck, L. and Nishanth, G. and Schlüter, D. and Uckert, W. and Schüler, T.
Journal of Immunology 194 (2): 553-559. 15 January 2015


HEK293-based production platform for γ-retroviral (SIN-) vectors: application for safe and efficient transfer of COL7A1 cDNA.
Hennig, K. and Raasch, L. and Kolbe, C. and Weidner, S. and Leisegang, M. and Uckert, W. and Titeux, M. and Hovnanian, A. and Kuehlcke, K. and Loew, R.
Human Gene Therapy Clinical Development 25 (4): 218-228. December 2014

RNAi-mediated TCR knockdown prevents autoimmunity in mice caused by mixed TCR dimers following TCR gene transfer.
Bunse, M. and Bendle, G.M. and Linnemann, C. and Bies, L. and Schulz, S. and Schumacher, T.N. and Uckert, W.
Molecular Therapy 22 (11): 1983-1991. November 2014

Manufacture of gene modified human T cells with a memory stem/ central memory phenotype.
Gomez-Eerland, R. and Nuijen, B. and Heemskerk, B. and van Rooij, N. and van den Berg, J.H. and Beijnen, J.H. and Uckert, W. and Kvistborg, P. and Schumacher, T. and Haanen, J.B.A.G. and Jorritsma, A.
Human Gene Therapy Methods 25 (5): 277-287. October 2014

Targeting high-grade B cell lymphoma with CD19-specific T cells.
Lehmann, F.M. and Maurberger, A. and Feicht, S. and Helm, F. and Ladinig, C. and Kieback, E. and Uckert, W. and Kammertöns, T. and Kremmer, E. and Mautner, J. and Gerbitz, A. and Bornkamm, G.W.
International Journal of Cancer 135 (5): 1153-1164. 1 September 2014

Misinitiation of intrathymic MART-1 transcription and biased TCR usage explain the high frequency of MART-1-specific T cells.
Pinto, S. and Sommermeyer, D. and Michel, C. and Wilde, S. and Schendel, D. and Uckert, W. and Blankenstein, T. and Kyewski, B.
European Journal of Immunology 44 (9): 2811-2821. September 2014

Immunotherapy with TCR-redirected T cells: comparison of TCR-transduced and TCR-engineered hematopoietic stem cell-derived T cells.
Stärck, L. and Popp, K. and Pircher, H. and Uckert, W.
Journal of Immunology 192 (1): 206-213. 1 January 2014

TCR-engineered T cells: a model of inducible TCR expression to dissect the interrelationship between two TCRs.
Reuß, S. and Sebestyén, Z. and Heinz, N. and Loew, R. and Baum, C. and Debets, R. and Uckert, W.
European Journal of Immunology 44 (1): 265-274. January 2014

A method for the generation of TCR retrogenic mice.
Kieback, E. and Hilgenberg, E. and Fillatreau, S.
Methods in Molecular Biology 1193 : 117-126. 2014


Plasticity in the contribution of T cell receptor variable region residues to binding of peptide-HLA-A2 complexes.
Smith, S.N. and Sommermeyer, D. and Piepenbrink, K.H. and Blevins, S.J. and Bernhard, H. and Uckert, W. and Baker, B.M. and Kranz, D.M.
Journal of Molecular Biology 425 (22): 4496-4507. 15 November 2013

T cells expressing a chimeric antigen receptor that binds hepatitis B virus envelop proteins control virus replication in mice.
Krebs, K. and Böttinger, N. and Huang, L.R. and Chmielewski, M. and Arzberger, S. and Gasteiger, G. and Jäger, C. and Schmitt, E. and Bohne, F. and Aichler, M. and Uckert, W. and Abken, H. and Heikenwalder, M. and Knolle, P. and Protzer, U.
Gastroenterology 145 (2): 456-465. August 2013

TCR-ligand k(off) rate correlates with the protective capacity of antigen-specific CD8(+) T cells for adoptive transfer.
Nauerth, M. and Weissbrich, B. and Knall, R. and Franz, T. and Dössinger, G. and Bet, J. and Paszkiewicz, P.J. and Pfeifer, L. and Bunse, M. and Uckert, W. and Holtappels, R. and Gillert-Marien, D. and Neuenhahn, M. and Krackhardt, A. and Reddehase, M.J. and Riddell, S.R. and Busch, D.H.
Science Translational Medicine 5 (192): 192ra87. 3 July 2013

MHC multimer-guided and cell culture-independent isolation of functional T cell receptors from single cells facilitates TCR identification for immunotherapy.
Dössinger, G. and Bunse, M. and Bet, J. and Albrecht, J. and Paszkiewicz, P.J. and Weißbrich, B. and Schiedewitz, I. and Henkel, L. and Schiemann, M. and Neuenhahn, M. and Uckert, W. and Busch, D.H.
PLoS ONE 8 (4): e61384. 26 April 2013

NY-ESO-1 antigen-reactive T cell receptors exhibit diverse therapeutic capability.
Sommermeyer, D. and Conrad, H. and Krönig, H. and Gelfort, H. and Bernhard, H. and Uckert, W.
International Journal of Cancer 132 (6): 1360-1367. 15 March 2013


T cell receptor gene transfer exclusively to human CD8+ cells enhances tumor cell killing.
Zhou, Q. and Schneider, I.C. and Edes, I. and Honegger, A. and Bach, P. and Schoenfeld, K. and Schambach, A. and Wels, W.S. and Kneissl, S. and Uckert, W. and Buchholz, C.J.
Blood 120 (22): 4334-4342. 22 November 2012

Protective capacity of virus-specific T cell receptor (TCR)-transduced CD8 T cells in vivo.
Mueller, K. and von Maessenhausen, A. and Aichele, U. and Staerck, L. and Leisegang, M. and Uckert, W. and Pircher, H.
Journal of Virology 86 (19): 10866-10869. October 2012

Human antitumor CD8+ T cells producing Th1 polycytokines show superior antigen sensitivity and tumor recognition.
Wilde, S. and Sommermeyer, D. and Leisegang, M. and Frankenberger, B. and Mosetter, B. and Uckert, W. and Schendel, D.J.
Journal of Immunology 189 (2): 598-605. 15 July 2012

TCR-transgenic lymphocytes specific for HMMR/Rhamm limit tumor outgrowth in vivo.
Spranger, S. and Jeremias, I. and Wilde, S. and Leisegang, M. and Staerck, L. and Mosetter, B. and Uckert, W. and Heemskerk, M.H.M. and Schendel, D.J. and Frankenberger, B.
Blood 119 (15): 3440-3449. 12 April 2012


The only proposed T-cell epitope derived from the TEL-AML1 translocation is not naturally processed.
Popovic, J. and Li, L.P. and Kloetzel, P.M. and Leisegang, M. and Uckert, W. and Blankenstein, T.
Blood 118 (4): 946-954. 28 July 2011

Transmitter- and hormone-activated Ca(2+) responses in adult microglia/brain macrophages in situ recorded after viral transduction of a recombinant Ca(2+) sensor.
Seifert, S. and Pannell, M. and Uckert, W. and Faerber, K. and Kettenmann, H.
Cell Calcium 49 (6): 365-375. June 2011

Tumor rejection by local interferon gamma induction in established tumors is associated with blood vessel destruction and necrosis.
Briesemeister, D. and Sommermeyer, D. and Loddenkemper, C. and Loew, R. and Uckert, W. and Blankenstein, T. and Kammertoens, T.
International Journal of Cancer 128 (2): 371-378. 15 January 2011


MHC-restricted fratricide of human lymphocytes expressing survivin-specific transgenic T cell receptors.
Leisegang, M. and Wilde, S. and Spranger, S. and Milosevic, S. and Frankenberger, B. and Uckert, W. and Schendel, D.J.
Journal of Clinical Investigation 120 (11): 3869-3877. 1 November 2010

Targeting the epidermal growth factor receptor (HER) family by T cell receptor gene-modified T lymphocytes.
Meyerhuber, P. and Conrad, H. and Staerck, L. and Leisegang, M. and Busch, D.H. and Uckert, W. and Bernhard, H.
Journal of Molecular Medicine 88 (11): 1113-1121. November 2010

Do CARs need a driver's license? Adoptive cell therapy with chimeric antigen receptor-redirected T cells caused serious adverse events.
Buening, H. and Uckert, W. and Cichutek, K. and Hawkins, R.E. and Abken, H.
Human Gene Therapy 21 (9): 1039-1042. September 2010

Interleukin-9 (IL-9) and NPM-ALK each generate mast cell hyperplasia as single 'hit' and cooperate in producing a mastocytosis-like disease in mice.
Merz, H. and Kaehler, C. and Hoefig, K.P. and Branke, B. and Uckert, W. and Nadrowitz, R. and Cerny-Reiterer, S. and Herrmann, H. and Feller, A.C. and Valent, P.
Oncotarget 1 (2): 104-119. 7 June 2010

Minimal amino acid exchange in human TCR constant regions fosters improved function of TCR gene-modified T cells.
Sommermeyer, D. and Uckert, W.
Journal of Immunology 184 (11): 6223-6231. 1 June 2010

Enhanced T cell receptor gene therapy for cancer.
Kieback, E. and Uckert, W.
Expert Opinion on Biological Therapy 10 (5): 749-762. May 2010

Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy.
Bendle, G.M. and Linnemann, C. and Hooijkaas, A.I. and Bies, L. and de Witte, M.A. and Jorritsma, A. and Kaiser, A.D.M. and Pouw, N. and Debets, R. and Kieback, E. and Uckert, W. and Song, J.Y. and Haanen, J.B.A.G. and Schumacher, T.N.M.
Nature Medicine 16 (5): 565-570, 1p following 570. May 2010

T-cell receptor gene-modified T cells with shared renal cell carcinoma specificity for adoptive T-cell therapy.
Leisegang, M. and Turqueti-Neves, A. and Engels, B. and Blankenstein, T. and Schendel, D.J. and Uckert, W. and Noessner, E.
Clinical Cancer Research 16 (8): 2333-2343. 15 April 2010

A single TCRα-chain with dominant peptide recognition in the allorestricted HER2/neu-specific T cell repertoire.
Liang, X. and Weigand, L.U. and Schuster, I.G. and Eppinger, E. and van der Griendt, J.C. and Schub, A. and Leisegang, M. and Sommermeyer, D. and Anderl, F. and Han, Y. and Ellwart, J. and Moosmann, A. and Busch, D.H. and Uckert, W. and Peschel, C. and Krackhardt, A.M.
Journal of Immunology 184 (3): 1617-1629. 1 February 2010


Dendritic cells pulsed with RNA encoding allogeneic MHC and antigen induce T cells with superior antitumor activity and higher TCR functional avidity.
Wilde, S. and Sommermeyer, D. and Frankenberger, B. and Schiemann, M. and Milosevic, S. and Spranger, S. and Pohla, H. and Uckert, W. and Busch, D.H. and Schendel, D.J.
Blood 114 (10): 2131-2139. 3 September 2009

The tumor-associated antigen EBAG9 negatively regulates the cytolytic capacity of mouse CD8+ T cells.
Rueder, C. and Höpken, U.E. and Wolf, J. and Mittruecker, H.W. and Engels, B. and Erdmann, B. and Wollenzin, S. and Uckert, W. and Dörken, B. and Rehm, A.
Journal of Clinical Investigation 119 (8): 2184-2203. August 2009

TCR transgenes and transgene cassettes for TCR gene therapy: status in 2008.
Uckert, W. and Schumacher, T.N.
Cancer Immunology Immunotherapy 58 (5): 809-822. May 2009


The antitumorigenic response of neural precursors depends on subventricular proliferation and age.
Walzlein, J.H. and Synowitz, M. and Engels, B. and Markovic, D.S. and Gabrusiewicz, K. and Nikolaev, E. and Yoshikawa, K. and Kaminska, B. and Kempermann, G. and Uckert, W. and Kaczmarek, L. and Kettenmann, H. and Glass, R.
Stem Cells 26 (11): 2945-2954. November 2008

Enhanced functionality of T cell receptor-redirected T cells is defined by the transgene cassette.
Leisegang, M. and Engels, B. and Meyerhuber, P. and Kieback, E. and Sommermeyer, D. and Xue, S.A. and Reuß, S. and Stauss, H. and Uckert, W.
Journal of Molecular Medicine 86 (5): 573-583. May 2008

A safeguard eliminates T cell receptor gene-modified autoreactive T cells after adoptive transfer.
Kieback, E. and Charo, J. and Sommermeyer, D. and Blankenstein, T. and Uckert, W.
Proceedings of the National Academy of Sciences of the United States of America 105 (2): 623-628. 15 January 2008


Neuroimmune crosstalk in asthma: dual role of the neurotrophin receptor p75NTR.
Nassenstein, C. and Kammertoens, T. and Veres, T.Z. and Uckert, W. and Spies, E. and Fuchs, B. and Krug, N. and Braun, A.
Journal of Allergy and Clinical Immunology 120 (5): 1089-1096. November 2007

Dual T cell receptor expressing CD8+ T cells with tumor- and self-specificity can inhibit tumor growth without causing severe autoimmunity.
Weinhold, M. and Sommermeyer, D. and Uckert, W. and Blankenstein, T.
Journal of Immunology 179 (8): 5534-5542. 15 October 2007

CD8alpha/alpha homodimers fail to function as co-receptor for a CD8-dependent TCR.
McNicol, A.M. and Bendle, G. and Holler, A. and Matjeka, T. and Dalton, E. and Rettig, L. and Zamoyska, R. and Uckert, W. and Xue, S.A. and Stauss, H.J.
European Journal of Immunology 37 (6): 1634-1641. June 2007

Suspension packaging cell lines for the simplified generation of T-cell receptor encoding retrovirus vector particles.
Reuß, S. and Biese, P. and Cosset, F.L. and Takeuchi, Y. and Uckert, W.
Gene Therapy 14 (7): 595-603. April 2007

Redirecting T lymphocyte specificity by T cell receptor gene transfer - a new era for immunotherapy.
Engels, B. and Uckert, W.
Molecular Aspects of Medicine 28 (1): 115-142. February 2007

Construction of a T cell line-based packaging cell line for the production of T cell receptor retroviruses by enriching of Cd3 expressing cells.
Uckert, W. and Blankenstein, T.
WO0700318. 4 January 2007


Designer T cells by T cell receptor replacement.
Sommermeyer, D. and Neudorfer, J. and Weinhold, M. and Leisegang, M. and Engels, B. and Noessner, E. and Heemskerk, M.H. and Charo, J. and Schendel, D.J. and Blankenstein, T. and Bernhard, H. and Uckert, W.
European Journal of Immunology 36 (11): 3052-3059. November 2006

The translocation motif of hepatitis B virus improves protein vaccination.
Bleifuss, E. and Kammertoens, T. and Hutloff, A. and Quarcoo, D. and Dorner, M. and Straub, P. and Uckert, W. and Hildt, E.
Cellular and Molecular Life Sciences 63 : 627-635. March 2006

Factors influencing subcellular localization of the human papillomavirus L2 minor structural protein.
Kieback, E. and Mueller, M.
Virology 345 (1): 199-208. 5 February 2006

Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma.
Mathas, S. and Janz, M. and Hummel, F. and Hummel, M. and Wollert-Wulf, B. and Lusatis, S. and Anagnostopoulos, I. and Lietz, A. and Sigvardsson, M. and Jundt, F. and Joehrens, K. and Bommert, K. and Stein, H. and Doerken, B.
Nature Immunology 7 (2): 207-215. February 2006

Global analysis of host tissue gene expression in the invasive front of colorectal liver metastases.
Bandapalli, O.R. and Geheeb, M. and Kobelt, D. and Kuehnle, K. and Elezkurtaj, S. and Herrmann, J. and Gressner, A.M. and Weiskirchen, R. and Beule, D. and Blüthgen, N. and Herzel, H. and Franke, C. and Brand, K.
International Journal of Cancer 118 : 74-89. 1 January 2006


Mechanismen der Immunmodulation durch die Genprodukte US11 und US28 des humanen Zytomegalievirus.
Droese, J.
UNSPECIFIED thesis, UNSPECIFIED. 8 November 2005

Elimination of human leukemia cells in NOD/SCID mice by WT1-TCR gene transduced human T cells.
Xue, S.A. and Gao, L. and Hart, D. and Gillmore, R. and Qasim, W. and Thrasher, A. and Apperley, J. and Engels, B. and Uckert, W. and Morris, E. and Stauss, H.J.
Blood 106 : 3062-3067. 14 July 2005

Redirecting human T lymphocytes toward renal cell carcinoma specificity by retroviral transfer of T cell receptor genes.
Engels, B. and Noessner, E. and Frankenberger, B. and Blankenstein, T. and Schendel, D.J. and Uckert, W.
Human Gene Therapy 16 (7): 799-810. 1 July 2005

Gentherapie mit T-Zellrezeptor modifizierten Zellen.
Uckert, W. and Blankenstein, T.
BioForum 28 (3): 27-30. 20 May 2005

Tumorspezifische Targeting der humanen natuerlichen Killerzellinie YT durch Gentransfer chimaerer Immunglobulin-T-Zellrezeptoren.
Schirrmann, T.
UNSPECIFIED thesis, UNSPECIFIED. 15 April 2005

CY15, a malignant histiocytic tumor that is phenotypically similar to immature dendritic cells.
Kammertoens, T. and Willebrand, R. and Erdmann, B. and Li, L. and Li, Y. and Engels, B. and Uckert, W. and Blankenstein, T.
Cancer Research 65 : 2560-2564. 1 January 2005

Progressive and controlled development of mouse dendritic cells from Flt3+ CD11b+ progenitors in vitro.
Hieronymus, T. and Gust, T.C. and Kirsch, R.D. and Jorgas, T. and Blendinger, G. and Goncharenko, M. and Supplitt, K. and Rose-John, S. and Mueller, A.M. and Zenke, M.
Journal of Immunology 174 (5): 2552-2562. 1 January 2005


Adenovirus-mediated overexpression of tissue inhibitor of metalloproteinases-1 in the liver: efficient protection against T-cell lymphoma and colon carcinoma metastasis.
Elezkurtaj, S. and Kopitz, C. and Baker, A.H. and Perez-Canto, A. and Arlt, M.J. and Khokha, R. and Gansbacher, B. and Anton, M. and Brand, K. and Krueger, A.
Journal of Gene Medicine 6 (11): 1228-1237. 23 September 2004

Dual T cell receptor T cells with two defined specificities mediate tumor suppression via both receptors.
Gladow, M. and Uckert, W. and Blankenstein, T.
European Journal of Immunology 34 (7): 1882-1891. 1 July 2004

A sensitive noninvasive method for monitoring successful liver-directed gene transfer of the low-density lipoprotein receptor in Watanabe hyperlipidemic rabbits in vivo.
Tietge, U.J.F. and Cichon, G. and Buettner, C. and Genschel, J. and Heeren, J. and Gielow, P. and Grewe, N. and Dogar, M. and Beisiegel, U. and Manns, M.P. and Lochs, H. and Burchert, W. and Schmidt, H.H.J.
Gene Therapy 11 (7): 574-580. April 2004

Non-physiological overexpression of the low density lipoprotein receptor (LDLr) gene in the liver induces pathological intracellular lipid and cholesterol storage.
Cichon, G. and Willnow, T.E. and Herwig, S. and Uckert, W. and Loeser, P. and Schmidt, H.H. and Benhidjeb, T. and Schlag, P.M. and Schnieders, F. and Niedzielska, D. and Heeren, J.
Journal of Gene Medicine 6 (2): 166-175. February 2004

Identification of an ovine atadenovirus gene whose product activates the viral E2 promoter: possible involvement of E2F-1.
Kuemin, D. and Hofmann, C. and Uckert, W. and Both, G.W. and Loeser, P.
Virology 318 (1): 79-89. 5 January 2004

Combination suicide gene therapy.
Uckert, W. and Salmons, B. and Beltinger, C. and Guenzburg, W.H. and Kammertoens, T.
In: Suicide Gene Therapy : Methods and Reviews. Methods in Molecular Medicine ; 90 . Humana Press, Totowa, NJ, 345-352. ISBN 0-89603-971-4 1 January 2004

Recombinant ovine atadenovirus induces a strong and sustained T cell response against the hepatitis C virus NS3 antigen in mice.
Wuest, T. and Both, G.W. and Prince, A.M. and Hofmann, C. and Loeser, P.
Vaccine 22 (21-22): 2717-2721. 1 January 2004


Transduction efficiency of MLV but not of HIV-1 vectors is pseudotype dependent on human primary T lymphocytes.
Muehlebach, M.D. and Schmitt, I. and Steidl, S. and Stitz, J. and Schweizer, M. and Blankenstein, T. and Cichutek, K. and Uckert, W.
Journal of Molecular Medicine 81 (12): 801-810. December 2003

Construction, rescue, and characterization of vectors derived from ovine atadenovirus.
Loeser, P. and Hofmann, C. and Both, G.W. and Uckert, W. and Hillgenberg, M.
Journal of Virology 77 (22): 11941-11951. November 2003

Retroviral vectors for high-level transgene expression in T lymphocytes.
Engels, B. and Cam, H. and Schueler, T. and Indraccolo, S. and Gladow, M. and Baum, C. and Blankenstein, T. and Uckert, W.
Human Gene Therapy 14 (12): 1155-1168. 10 August 2003

Titer determination of Ad5 in blood: a cautionary note.
Cichon, G. and Boeckh-Herwig, S. and Kuemin, D. and Hoffmann, C. and Schmidt, H.H. and Wehnes, E. and Haensch, W. and Schneider, U. and Eckhardt, U. and Burger, R. and Pring-Akerblom, P.
Gene Therapy 10 (12): 1012-1017. June 2003

Overexpression of NPM-ALK induces different types of malignant lymphomas in IL-9 transgenic mice.
Lange, K. and Uckert, W. and Blankenstein, T. and Nadrowitz, R. and Bittner, C. and Renauld, J.C. and van Snick, J. and Feller, A.C. and Merz, H.
Oncogene 22 (4): 517-527. 30 January 2003

Die Ueberexpression von NPM-ALK in haematopoietischen Stammzellen induziert verschiedene maligne Non-Hodgkin-Lymphome in der IL-9 transgenen Maus [Overexpression of NPM-ALK induces different types of malignant lymphomas in IL-9 transgenic mice].
Merz, H. and Lange, K. and Nadrowitz, R. and Uckert, W. and Blankenstein, T. and Feller, A.C.
Verhandlungen der Deutschen Gesellschaft fuer Pathologie 87 : 224-231. 1 January 2003


Biology of ovine adenovirus infection of nonpermissive cells.
Kuemin, D. and Hofmann, C. and Rudolph, M. and Both, G.W. and Loeser, P.
Journal of Virology 76 : 10882-10893. 1 November 2002

The human T cell response to myelin oligodendrocyte glycoprotein: a multiple sclerosis family-based study.
Koehler, N.K. and Genain, C.P. and Giesser, B. and Hauser, S.L.
Journal of Immunology 168 : 5920-5927. 1 June 2002

Hepatocarcinoma cells constitutively expressing adenoviral E1-genes provide a tumor model for intratumoral replication of E1-deficient adenoviruses.
Cichon, G. and Boeckh-Herwig, S. and Elezkurtaj, S. and Schmidt, H.H. and Hofmann, C. and Arnold, W.
Anticancer Research 22 (1A): 197-201. May 2002


Complement activation by recombinant adenoviruses.
Cichon, G. and Boeckh-Herwig, S. and Schmidt, H.H. and Wehnes, E. and Mueller, T. and Pring-Akerblom, P. and Burger, R.
Gene Therapy 8 : 1794-1800. 1 December 2001

Suicide gene therapy for pediatric tumors.
Beltinger, C. and Uckert, W. and Debatin, K.M.
Journal of Molecular Medicine 78 (11): 598-612. 1 January 2001


Ovine adenovirus vectors mediate efficient gene transfer to skeletal muscle.
Loeser, P. and Hillgenberg, M. and Arnold, W. and Both, G.W. and Hofmann, C.
Gene Therapy 7 : 1491-1498. 1 September 2000

Combined chemotherapy of murine mammary tumors by local activation of the prodrugs ifosfamide and 5-fluorocytosine.
Kammertoens, T. and Gelbmann, W. and Karle, P. and Alton, K. and Saller, R. and Salmons, B. and Guenzburg, W.H. and Uckert, W.
Cancer Gene Therapy 7 (4): 629-636. 1 April 2000

Efficient gene transfer into primary human CD8+ T lymphocytes by MuLV-10A1 retrovirus pseudotype.
Uckert, W. and Becker, C. and Gladow, M. and Klein, D. and Kammertoens, T. and Pedersen, L. and Blankenstein, T.
Human Gene Therapy 11 (7): 1005-1014. 1 January 2000

Emerging therapies in hepatology: Liver-directed gene transfer and hepatocyte transplantation.
Ott, M. and Schmidt, H.H.J. and Cichon, G. and Manns, M.P.
Cells Tissues Organs 167 (2-3): 81-87. 1 January 2000

Green fluorescent protein retroviral vector. Generation of high-titer producer cells and virus supernatant.
Uckert, W. and Pedersen, L. and Guenzburg, W.
In: Gene Therapy of Cancer : Methods and Protocols. Methods in Molecular Medicine. ; 35 . Humana Press, Totowa,NJ, 275-285. 1 January 2000

Lentiviral vectors pseudotyped with envelope glycoproteins derived from gibbon ape leukemia virus and murine leukemia virus 10A1.
Stitz, J. and Buchholz, C.J. and Engelstaedter, M. and Uckert, W. and Bloemer, U. and Schmitt, I. and Cichutek, K.
Virology 273 (1): 16-20. 1 January 2000

MLV-10A1 retrovirus pseudotype efficiently transduces primary human CD4+ T lymphocytes.
Gladow, M. and Becker, C. and Blankenstein, T. and Uckert, W.
Journal of Gene Medicine 2 (6): 409-415. 1 January 2000

Mitochondrial amplification of death signals determines thymidine kinase/ ganciclovir-triggered activation of apoptosis.
Beltinger, C. and Fulda, S. and Kammertoens, T. and Uckert, W. and Debatin, K.M.
Cancer Research 60 (12): 3212-3217. 1 January 2000

Modulation of moloney leukemia virus long terminal repeat transcriptionalactivity by the murine CD4 silencer in retroviral vectors.
Indraccolo, S. and Minuzzo, S. and Habeler, W. and Zamarchi, R. and Fregonese, A. and Guenzburg, W.H. and Salmons, B. and Uckert, W. and Chieco-Bianchi, L. and Amadori, A.
Virology 276 : 83-92. 1 January 2000


Nonphysiological overexpression of low-density lipoprotein receptors causes pathological intracellular lipid accumulation and the formation of cholesterol and cholesteryl ester crystals in vitro.
Heeren, J. and Steinwaerder, D.S. and Schnieders, F. and Cichon, G. and Strauss, M. and Beisiegel, U.
Journal of Molecular Medicine 77 (10): 735-743. October 1999

Intravenous administration of recombinant adenoviruses causes thrombocytopenia, anemia and erythroblastosis in rabbits.
Cichon, G. and Schmidt, H.H. and Benhidjeb, T. and Loeser, P. and Ziemer, S. and Haas, R. and Grewe, N. and Schnieders, F. and Heeren, J. and Manns, M.P. and Schlag, P.M. and Strauss, M.
Journal of Gene Medicine 1 : 360-371. 1 September 1999

Ovine adenovirus vectors overcome preexisting humoral immunity against human adenoviruses in vivo.
Hofmann, C. and Loeser, P. and Cichon, G. and Arnold, W. and Both, G.W. and Strauss, M.
Journal of Virology 73 : 6930-6936. 1 August 1999

Herpes simplex virus thymidine kinase/ganciclovir-induced apoptosis involves ligand-independent death receptor aggregation and activation of caspases.
Beltinger, C. and Fulda, S. and Kammertoens, T. and Meyer, E. and Uckert, W. and Debatin, K.M.
Proceedings of the National Academy of Sciences of the United States of America 96 : 8699-8704. 20 July 1999

Gene Therapy of Familial Hypercholesterolemia.
Cichon, G. and Strauss, M.
In: Gene therapy :Principles and Applications. Birkhaeuser, Basel, 151-167. ISBN 3-7643-5972-2 1 January 1999


Double suicide gene (cytosine deaminase and herpes simplex virus thymidine kinase) but not single gene transfer allows reliable elimination of tumor cells in vivo.
Uckert, W. and Kammertoens, T. and Haack, K. and Qin, Z. and Gebert, J. and Schendel, D.J. and Blankenstein, T.
Human Gene Therapy 9 : 855-865. 1 January 1998

Large and small scale RNA preparations from eukaryotic cells.
Uckert, W. and Walther, W. and Stein, U.
In: RNA Isolation and Characterization Protocols. Methods in Molecular Biology ; 86 . Humana Press, Totowa,NJ, 7-14. 1 January 1998

RNA levels of human retrovirus receptors Pit1 and Pit2 do not correlate with infectibility by three retroviral vector pseudotypes.
Uckert, W. and Willimsky, G. and Pedersen, F.S. and Blankenstein, T. and Pedersen, L.
Human Gene Therapy 9 : 2619-2627. 1 January 1998

Transient immunosuppression with 15-deoxyspergualin prolongs reporter gene expression and reduces humoral immune response after adenoviral gene transfer.
Cichon, G. and Strauss, M.
Gene Therapy 5 : 85-90. 1 January 1998


Influence of retrovirally transduced human tumor-necrosis-factor-alpha on the expression of C-myc, k-ras, C-jun, p53, tgf-alpha, and cea in human colon-carcinoma cell-lines.
Uckert, W. and Walther, W. and Hummel, O.
International Journal of Oncology 6 : 1027-1031. 1 January 1995


Conditional expression of human TNF-alpha: a system for inducible cytotoxicity.
Sparmann, G. and Walther, W. and Guenzburg, W.H. and Uckert, W. and Salmons, B.
International Journal of Cancer 59 : 103-107. 1 January 1994

Retrovirus-mediated gene transfer in cancer therapy.
Uckert, W. and Walther, W.
Pharmacology & Therapeutics 63 : 323-347. 1 January 1994


Retrovirus-mediated gene transfer of tumor necrosis factor alpha into colon carcinoma cells generates a growth inhibition.
Walther, W. and Fichtner, I. and Uckert, W.
Anticancer Research 13 : 1565-1574. 1 January 1993


Retroviral transduction of the human TNF alpha gene into tumour cells generates a growth inhibitory effect.
Walther, W. and Huth, J. and Sparmann, G. and Uckert, W.
In: European Biotechnology Today. INTERCEPT Ltd., Andover, 209-216. 1 January 1992

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