Browse by Research Team

Acta Neuropathologica

Distinguishing features of microglia- and monocyte-derived macrophages after stroke.
Kronenberg, G., Uhlemann, R., Richter, N., Klempin, F., Wegner, S., Staerck, L., Wolf, S., Uckert, W., Kettenmann, H., Endres, M. and Gertz, K.
Acta Neuropathologica 135 (4): 551. April 2018

Anticancer Research

Hepatocarcinoma cells constitutively expressing adenoviral E1-genes provide a tumor model for intratumoral replication of E1-deficient adenoviruses.
Cichon, G., Boeckh-Herwig, S., Elezkurtaj, S., Schmidt, H.H., Hofmann, C. and Arnold, W.
Anticancer Research 22 (1A): 197-201. May 2002

Retrovirus-mediated gene transfer of tumor necrosis factor alpha into colon carcinoma cells generates a growth inhibition.
Walther, W., Fichtner, I. and Uckert, W.
Anticancer Research 13 : 1565-1574. 1 January 1993

BIOspektrum

Designer T cells - New possibilities for immunotherapy of cancer [Designer-T-Zellen - neue Möglichkeiten für die Immuntherapie von Krebs].
Leisegang, M. and Uckert, W.
BIOspektrum 21 (4): 402-405. June 2015

BioForum

Gentherapie mit T-Zellrezeptor modifizierten Zellen.
Uckert, W. and Blankenstein, T.
BioForum 28 (3): 27-30. 20 May 2005

Blood

In vivo transduction of primitive mobilized hematopoietic stem cells after intravenous injection of integrating adenovirus vectors.
Richter, M., Saydaminova, K., Yumul, R., Krishnan, R., Liu, J., Nagy, E.E., Singh, M., Izsvák, Z., Cattaneo, R., Uckert, W., Palmer, D., Ng, P., Haworth, K.G., Kiem, H.P., Ehrhardt, A., Papayannopoulou, T. and Lieber, A.
Blood 128 (18): 2206-2217. 3 November 2016

T cell receptor gene transfer exclusively to human CD8+ cells enhances tumor cell killing.
Zhou, Q., Schneider, I.C., Edes, I., Honegger, A., Bach, P., Schoenfeld, K., Schambach, A., Wels, W.S., Kneissl, S., Uckert, W. and Buchholz, C.J.
Blood 120 (22): 4334-4342. 22 November 2012

TCR-transgenic lymphocytes specific for HMMR/Rhamm limit tumor outgrowth in vivo.
Spranger, S., Jeremias, I., Wilde, S., Leisegang, M., Staerck, L., Mosetter, B., Uckert, W., Heemskerk, M.H.M., Schendel, D.J. and Frankenberger, B.
Blood 119 (15): 3440-3449. 12 April 2012

The only proposed T-cell epitope derived from the TEL-AML1 translocation is not naturally processed.
Popovic, J., Li, L.P., Kloetzel, P.M., Leisegang, M., Uckert, W. and Blankenstein, T.
Blood 118 (4): 946-954. 28 July 2011

Dendritic cells pulsed with RNA encoding allogeneic MHC and antigen induce T cells with superior antitumor activity and higher TCR functional avidity.
Wilde, S., Sommermeyer, D., Frankenberger, B., Schiemann, M., Milosevic, S., Spranger, S., Pohla, H., Uckert, W., Busch, D.H. and Schendel, D.J.
Blood 114 (10): 2131-2139. 3 September 2009

Elimination of human leukemia cells in NOD/SCID mice by WT1-TCR gene transduced human T cells.
Xue, S.A., Gao, L., Hart, D., Gillmore, R., Qasim, W., Thrasher, A., Apperley, J., Engels, B., Uckert, W., Morris, E. and Stauss, H.J.
Blood 106 : 3062-3067. 14 July 2005

Cancer Gene Therapy

Combined chemotherapy of murine mammary tumors by local activation of the prodrugs ifosfamide and 5-fluorocytosine.
Kammertoens, T., Gelbmann, W., Karle, P., Alton, K., Saller, R., Salmons, B., Guenzburg, W.H. and Uckert, W.
Cancer Gene Therapy 7 (4): 629-636. 1 April 2000

Cancer Immunology Immunotherapy

TCR transgenes and transgene cassettes for TCR gene therapy: status in 2008.
Uckert, W. and Schumacher, T.N.
Cancer Immunology Immunotherapy 58 (5): 809-822. May 2009

Cancer Immunology Research

Mapping the MHC class I spliced immunopeptidome of cancer cells.
Liepe, J., Sidney, J., Lorenz, F.K.M., Sette, A. and Mishto, M.
Cancer Immunology Research 7 (1): 62-76. January 2019

Cancer Research

Chimeric PD-1:28 receptor upgrades low-avidity T cells and restores effector function of tumor-infiltrating lymphocytes for adoptive cell therapy.
Schlenker, R., Olguín-Contreras, L.F., Leisegang, M., Schnappinger, J., Disovic, A., Rühland, S., Nelson, P.J., Leonhardt, H., Harz, H., Wilde, S., Schendel, D.J., Uckert, W., Willimsky, G. and Noessner, E.
Cancer Research 77 (13): 3577-3590. 1 July 2017

CY15, a malignant histiocytic tumor that is phenotypically similar to immature dendritic cells.
Kammertoens, T., Willebrand, R., Erdmann, B., Li, L., Li, Y., Engels, B., Uckert, W. and Blankenstein, T.
Cancer Research 65 : 2560-2564. 1 January 2005

Mitochondrial amplification of death signals determines thymidine kinase/ ganciclovir-triggered activation of apoptosis.
Beltinger, C., Fulda, S., Kammertoens, T., Uckert, W. and Debatin, K.M.
Cancer Research 60 (12): 3212-3217. 1 January 2000

Cell Calcium

Transmitter- and hormone-activated Ca(2+) responses in adult microglia/brain macrophages in situ recorded after viral transduction of a recombinant Ca(2+) sensor.
Seifert, S., Pannell, M., Uckert, W., Faerber, K. and Kettenmann, H.
Cell Calcium 49 (6): 365-375. June 2011

Cells Tissues Organs

Emerging therapies in hepatology: Liver-directed gene transfer and hepatocyte transplantation.
Ott, M., Schmidt, H.H.J., Cichon, G. and Manns, M.P.
Cells Tissues Organs 167 (2-3): 81-87. 1 January 2000

Cellular and Molecular Life Sciences

The translocation motif of hepatitis B virus improves protein vaccination.
Bleifuss, E., Kammertoens, T., Hutloff, A., Quarcoo, D., Dorner, M., Straub, P., Uckert, W. and Hildt, E.
Cellular and Molecular Life Sciences 63 : 627-635. March 2006

Clinical Cancer Research

Eradication of large solid tumors by gene therapy with a T cell receptor targeting a single cancer-specific point mutation.
Leisegang, M., Engels, B., Schreiber, K., Yew, P.Y., Kiyotani, K., Idel, C., Arina, A., Duraiswamy, J., Weichselbaum, R.R., Uckert, W., Nakamura, Y. and Schreiber, H.
Clinical Cancer Research 22 (11): 2734-2743. 1 June 2016

T-cell receptor gene-modified T cells with shared renal cell carcinoma specificity for adoptive T-cell therapy.
Leisegang, M., Turqueti-Neves, A., Engels, B., Blankenstein, T., Schendel, D.J., Uckert, W. and Noessner, E.
Clinical Cancer Research 16 (8): 2333-2343. 15 April 2010

Current Opinion in Immunology

Targeting cancer-specific mutations by T cell receptor gene therapy.
Blankenstein, T., Leisegang, M., Uckert, W. and Schreiber, H.
Current Opinion in Immunology 33 : 112-119. April 2015

European Journal of Immunology

Antigen receptor-engineered Tregs inhibit CNS autoimmunity in cell therapy using non-redundant immune mechanisms in mice.
Pohar, J., O'Connor, R., Manfroi, B., Behi, M.E., Jouneau, L., Boudinot, P., Bunse, M., Uckert, W., Luka, M., Ménager, M., Liblau, R., Anderton, S.M. and Fillatreau, S.
European Journal of Immunology 52 (8): 1335-1349. August 2022

ER-aminopeptidase 1 determines the processing and presentation of an immunotherapy-relevant melanoma epitope.
Textoris-Taube, K., Cammann, C., Henklein, P., Topfstedt, E., Ebstein, F., Henze, S., Liepe, J., Zhao, F., Schadendorf, D., Dahlmann, B., Uckert, W., Paschen, A., Mishto, M. and Seifert, U.
European Journal of Immunology 50 (2): 270-283. February 2020

Misinitiation of intrathymic MART-1 transcription and biased TCR usage explain the high frequency of MART-1-specific T cells.
Pinto, S., Sommermeyer, D., Michel, C., Wilde, S., Schendel, D., Uckert, W., Blankenstein, T. and Kyewski, B.
European Journal of Immunology 44 (9): 2811-2821. September 2014

TCR-engineered T cells: a model of inducible TCR expression to dissect the interrelationship between two TCRs.
Reuß, S., Sebestyén, Z., Heinz, N., Loew, R., Baum, C., Debets, R. and Uckert, W.
European Journal of Immunology 44 (1): 265-274. January 2014

CD8alpha/alpha homodimers fail to function as co-receptor for a CD8-dependent TCR.
McNicol, A.M., Bendle, G., Holler, A., Matjeka, T., Dalton, E., Rettig, L., Zamoyska, R., Uckert, W., Xue, S.A. and Stauss, H.J.
European Journal of Immunology 37 (6): 1634-1641. June 2007

Designer T cells by T cell receptor replacement.
Sommermeyer, D., Neudorfer, J., Weinhold, M., Leisegang, M., Engels, B., Noessner, E., Heemskerk, M.H., Charo, J., Schendel, D.J., Blankenstein, T., Bernhard, H. and Uckert, W.
European Journal of Immunology 36 (11): 3052-3059. November 2006

Dual T cell receptor T cells with two defined specificities mediate tumor suppression via both receptors.
Gladow, M., Uckert, W. and Blankenstein, T.
European Journal of Immunology 34 (7): 1882-1891. 1 July 2004

Expert Opinion on Biological Therapy

Enhanced T cell receptor gene therapy for cancer.
Kieback, E. and Uckert, W.
Expert Opinion on Biological Therapy 10 (5): 749-762. May 2010

Gastroenterology

T cells engineered to express a T-cell receptor specific for glypican-3 recognize and kill hepatoma cells in vitro and in mice.
Dargel, C., Bassani-Sternberg, M., Hasreiter, J., Zani, F., Bockmann, J.H., Thiele, F., Bohne, F., Wisskirchen, K., Wilde, S., Sprinzl, M.F., Schendel, D.J., Krackhardt, A.M., Uckert, W., Wohlleber, D., Schiemann, M., Stemmer, K., Heikenwälder, M., Busch, D.H., Richter, G., Mann, M. and Protzer, U.
Gastroenterology 149 (4): 1042-1052. October 2015

T cells expressing a chimeric antigen receptor that binds hepatitis B virus envelop proteins control virus replication in mice.
Krebs, K., Böttinger, N., Huang, L.R., Chmielewski, M., Arzberger, S., Gasteiger, G., Jäger, C., Schmitt, E., Bohne, F., Aichler, M., Uckert, W., Abken, H., Heikenwalder, M., Knolle, P. and Protzer, U.
Gastroenterology 145 (2): 456-465. August 2013

Gene Therapy

Suspension packaging cell lines for the simplified generation of T-cell receptor encoding retrovirus vector particles.
Reuß, S., Biese, P., Cosset, F.L., Takeuchi, Y. and Uckert, W.
Gene Therapy 14 (7): 595-603. April 2007

A sensitive noninvasive method for monitoring successful liver-directed gene transfer of the low-density lipoprotein receptor in Watanabe hyperlipidemic rabbits in vivo.
Tietge, U.J.F., Cichon, G., Buettner, C., Genschel, J., Heeren, J., Gielow, P., Grewe, N., Dogar, M., Beisiegel, U., Manns, M.P., Lochs, H., Burchert, W. and Schmidt, H.H.J.
Gene Therapy 11 (7): 574-580. April 2004

Titer determination of Ad5 in blood: a cautionary note.
Cichon, G., Boeckh-Herwig, S., Kuemin, D., Hoffmann, C., Schmidt, H.H., Wehnes, E., Haensch, W., Schneider, U., Eckhardt, U., Burger, R. and Pring-Akerblom, P.
Gene Therapy 10 (12): 1012-1017. June 2003

Complement activation by recombinant adenoviruses.
Cichon, G., Boeckh-Herwig, S., Schmidt, H.H., Wehnes, E., Mueller, T., Pring-Akerblom, P. and Burger, R.
Gene Therapy 8 : 1794-1800. 1 December 2001

Ovine adenovirus vectors mediate efficient gene transfer to skeletal muscle.
Loeser, P., Hillgenberg, M., Arnold, W., Both, G.W. and Hofmann, C.
Gene Therapy 7 : 1491-1498. 1 September 2000

Transient immunosuppression with 15-deoxyspergualin prolongs reporter gene expression and reduces humoral immune response after adenoviral gene transfer.
Cichon, G. and Strauss, M.
Gene Therapy 5 : 85-90. 1 January 1998

Human Gene Therapy

Gene therapy "Made in Germany": a historical perspective, analysis of the status quo, and recommendations for action by the German Society for Gene Therapy.
Büning, H., Fehse, B., Ivics, Z., Kochanek, S., Koehl, U., Kupatt, C., Mussolino, C., Nettelbeck, D.M., Schambach, A., Uckert, W., Wagner, E. and Cathomen, T.
Human Gene Therapy 32 (19-20): 987-996. 18 October 2021

Generation of Epstein-Barr virus antigen-specific T cell receptors recognizing immunodominant epitopes of LMP1, LMP2A, and EBNA3C for immunotherapy.
Dudaniec, K., Westendorf, K., Nössner, E. and Uckert, W.
Human Gene Therapy 32 (17-18): 919-935. 21 September 2021

CD8-specific designed ankyrin repeat proteins improve selective gene delivery into human and primate T lymphocytes.
Frank, A.M., Weidner, T., Brynza, J., Uckert, W., Buchholz, C.J. and Hartmann, J.
Human Gene Therapy 31 (11-12): 679-691. June 2020

Efficient non-viral T cell engineering by Sleeping Beauty minicircles diminishing DNA toxicity and miRNAs silencing the endogenous TCR.
Clauss, J., Obenaus, M., Miskey, C., Ivics, Z., Izsvák, Z., Uckert, W. and Bunse, M.
Human Gene Therapy 29 (5): 569-584. May 2018

Unbiased identification of T cell receptors targeting immunodominant peptide-MHC complexes for T cell receptor immunotherapy.
Lorenz, F.K.M., Ellinger, C., Kieback, E., Wilde, S., Lietz, M., Schendel, D.J. and Uckert, W.
Human Gene Therapy 28 (12): 1158-1168. 1 December 2017

Do CARs need a driver's license? Adoptive cell therapy with chimeric antigen receptor-redirected T cells caused serious adverse events.
Buening, H., Uckert, W., Cichutek, K., Hawkins, R.E. and Abken, H.
Human Gene Therapy 21 (9): 1039-1042. September 2010

Redirecting human T lymphocytes toward renal cell carcinoma specificity by retroviral transfer of T cell receptor genes.
Engels, B., Noessner, E., Frankenberger, B., Blankenstein, T., Schendel, D.J. and Uckert, W.
Human Gene Therapy 16 (7): 799-810. 1 July 2005

Retroviral vectors for high-level transgene expression in T lymphocytes.
Engels, B., Cam, H., Schueler, T., Indraccolo, S., Gladow, M., Baum, C., Blankenstein, T. and Uckert, W.
Human Gene Therapy 14 (12): 1155-1168. 10 August 2003

Efficient gene transfer into primary human CD8+ T lymphocytes by MuLV-10A1 retrovirus pseudotype.
Uckert, W., Becker, C., Gladow, M., Klein, D., Kammertoens, T., Pedersen, L. and Blankenstein, T.
Human Gene Therapy 11 (7): 1005-1014. 1 January 2000

Double suicide gene (cytosine deaminase and herpes simplex virus thymidine kinase) but not single gene transfer allows reliable elimination of tumor cells in vivo.
Uckert, W., Kammertoens, T., Haack, K., Qin, Z., Gebert, J., Schendel, D.J. and Blankenstein, T.
Human Gene Therapy 9 : 855-865. 1 January 1998

RNA levels of human retrovirus receptors Pit1 and Pit2 do not correlate with infectibility by three retroviral vector pseudotypes.
Uckert, W., Willimsky, G., Pedersen, F.S., Blankenstein, T. and Pedersen, L.
Human Gene Therapy 9 : 2619-2627. 1 January 1998

Human Gene Therapy Clinical Development

HEK293-based production platform for γ-retroviral (SIN-) vectors: application for safe and efficient transfer of COL7A1 cDNA.
Hennig, K., Raasch, L., Kolbe, C., Weidner, S., Leisegang, M., Uckert, W., Titeux, M., Hovnanian, A., Kuehlcke, K. and Loew, R.
Human Gene Therapy Clinical Development 25 (4): 218-228. December 2014

Human Gene Therapy Methods

Manufacture of gene modified human T cells with a memory stem/ central memory phenotype.
Gomez-Eerland, R., Nuijen, B., Heemskerk, B., van Rooij, N., van den Berg, J.H., Beijnen, J.H., Uckert, W., Kvistborg, P., Schumacher, T., Haanen, J.B.A.G. and Jorritsma, A.
Human Gene Therapy Methods 25 (5): 277-287. October 2014

Immunity

Thymus-derived regulatory T cells are positively selected on natural self-antigen through cognate interactions of high functional avidity.
Kieback, E., Hilgenberg, E., Stervbo, U., Lampropoulou, V., Shen, P., Bunse, M., Jaimes, Y., Boudinot, P., Radbruch, A., Klemm, U., Kühl, A.A., Liblau, R., Hoevelmeyer, N., Anderton, S.M., Uckert, W. and Fillatreau, S.
Immunity 44 (5): 1114-1126. 17 May 2016

International Journal of Cancer

Targeting high-grade B cell lymphoma with CD19-specific T cells.
Lehmann, F.M., Maurberger, A., Feicht, S., Helm, F., Ladinig, C., Kieback, E., Uckert, W., Kammertöns, T., Kremmer, E., Mautner, J., Gerbitz, A. and Bornkamm, G.W.
International Journal of Cancer 135 (5): 1153-1164. 1 September 2014

NY-ESO-1 antigen-reactive T cell receptors exhibit diverse therapeutic capability.
Sommermeyer, D., Conrad, H., Krönig, H., Gelfort, H., Bernhard, H. and Uckert, W.
International Journal of Cancer 132 (6): 1360-1367. 15 March 2013

Tumor rejection by local interferon gamma induction in established tumors is associated with blood vessel destruction and necrosis.
Briesemeister, D., Sommermeyer, D., Loddenkemper, C., Loew, R., Uckert, W., Blankenstein, T. and Kammertoens, T.
International Journal of Cancer 128 (2): 371-378. 15 January 2011

Global analysis of host tissue gene expression in the invasive front of colorectal liver metastases.
Bandapalli, O.R., Geheeb, M., Kobelt, D., Kuehnle, K., Elezkurtaj, S., Herrmann, J., Gressner, A.M., Weiskirchen, R., Beule, D., Blüthgen, N., Herzel, H., Franke, C. and Brand, K.
International Journal of Cancer 118 : 74-89. 1 January 2006

Conditional expression of human TNF-alpha: a system for inducible cytotoxicity.
Sparmann, G., Walther, W., Guenzburg, W.H., Uckert, W. and Salmons, B.
International Journal of Cancer 59 : 103-107. 1 January 1994

International Journal of Oncology

Influence of retrovirally transduced human tumor-necrosis-factor-alpha on the expression of C-myc, k-ras, C-jun, p53, tgf-alpha, and cea in human colon-carcinoma cell-lines.
Uckert, W., Walther, W. and Hummel, O.
International Journal of Oncology 6 : 1027-1031. 1 January 1995

Journal of Allergy and Clinical Immunology

Neuroimmune crosstalk in asthma: dual role of the neurotrophin receptor p75NTR.
Nassenstein, C., Kammertoens, T., Veres, T.Z., Uckert, W., Spies, E., Fuchs, B., Krug, N. and Braun, A.
Journal of Allergy and Clinical Immunology 120 (5): 1089-1096. November 2007

Journal of Clinical Investigation

Effective NY-ESO-1-specific MHC II-restricted T cell receptors from antigen-negative hosts enhance tumor regression.
Poncette, L., Chen, X., Lorenz, F.K.M. and Blankenstein, T.
Journal of Clinical Investigation 129 (1): 324-335. 2 January 2019

Targeting human melanoma neoantigens by T cell receptor gene therapy.
Leisegang, M., Kammertoens, T., Uckert, W. and Blankenstein, T.
Journal of Clinical Investigation 126 (3): 854-858. 1 March 2016

MHC-restricted fratricide of human lymphocytes expressing survivin-specific transgenic T cell receptors.
Leisegang, M., Wilde, S., Spranger, S., Milosevic, S., Frankenberger, B., Uckert, W. and Schendel, D.J.
Journal of Clinical Investigation 120 (11): 3869-3877. 1 November 2010

The tumor-associated antigen EBAG9 negatively regulates the cytolytic capacity of mouse CD8+ T cells.
Rueder, C., Höpken, U.E., Wolf, J., Mittruecker, H.W., Engels, B., Erdmann, B., Wollenzin, S., Uckert, W., Dörken, B. and Rehm, A.
Journal of Clinical Investigation 119 (8): 2184-2203. August 2009

Journal of Gene Medicine

Adenovirus-mediated overexpression of tissue inhibitor of metalloproteinases-1 in the liver: efficient protection against T-cell lymphoma and colon carcinoma metastasis.
Elezkurtaj, S., Kopitz, C., Baker, A.H., Perez-Canto, A., Arlt, M.J., Khokha, R., Gansbacher, B., Anton, M., Brand, K. and Krueger, A.
Journal of Gene Medicine 6 (11): 1228-1237. 23 September 2004

MLV-10A1 retrovirus pseudotype efficiently transduces primary human CD4+ T lymphocytes.
Gladow, M., Becker, C., Blankenstein, T. and Uckert, W.
Journal of Gene Medicine 2 (6): 409-415. 1 January 2000

Intravenous administration of recombinant adenoviruses causes thrombocytopenia, anemia and erythroblastosis in rabbits.
Cichon, G., Schmidt, H.H., Benhidjeb, T., Loeser, P., Ziemer, S., Haas, R., Grewe, N., Schnieders, F., Heeren, J., Manns, M.P., Schlag, P.M. and Strauss, M.
Journal of Gene Medicine 1 : 360-371. 1 September 1999

Journal of Immunology

CD8 T cell tolerance to a tumor-associated self-antigen is reversed by CD4 T cells engineered to express the same T cell receptor.
Ghorashian, S., Veliça, P., Chua, I., McNicol, A., Carpenter, B., Holler, A., Nicholson, E., Ahmadi, M., Zech, M., Xue, S., Uckert, W., Morris, E., Chakraverty, R. and Stauss, H.J.
Journal of Immunology 194 (3): 1080-1089. 1 February 2015

IFN-γ regulates CD8(+) memory T cell differentiation and survival in response to weak, but not strong, TCR signals.
Stoycheva, D., Deiser, K., Stärck, L., Nishanth, G., Schlüter, D., Uckert, W. and Schüler, T.
Journal of Immunology 194 (2): 553-559. 15 January 2015

Immunotherapy with TCR-redirected T cells: comparison of TCR-transduced and TCR-engineered hematopoietic stem cell-derived T cells.
Stärck, L., Popp, K., Pircher, H. and Uckert, W.
Journal of Immunology 192 (1): 206-213. 1 January 2014

Human antitumor CD8+ T cells producing Th1 polycytokines show superior antigen sensitivity and tumor recognition.
Wilde, S., Sommermeyer, D., Leisegang, M., Frankenberger, B., Mosetter, B., Uckert, W. and Schendel, D.J.
Journal of Immunology 189 (2): 598-605. 15 July 2012

Minimal amino acid exchange in human TCR constant regions fosters improved function of TCR gene-modified T cells.
Sommermeyer, D. and Uckert, W.
Journal of Immunology 184 (11): 6223-6231. 1 June 2010

A single TCRα-chain with dominant peptide recognition in the allorestricted HER2/neu-specific T cell repertoire.
Liang, X., Weigand, L.U., Schuster, I.G., Eppinger, E., van der Griendt, J.C., Schub, A., Leisegang, M., Sommermeyer, D., Anderl, F., Han, Y., Ellwart, J., Moosmann, A., Busch, D.H., Uckert, W., Peschel, C. and Krackhardt, A.M.
Journal of Immunology 184 (3): 1617-1629. 1 February 2010

Dual T cell receptor expressing CD8+ T cells with tumor- and self-specificity can inhibit tumor growth without causing severe autoimmunity.
Weinhold, M., Sommermeyer, D., Uckert, W. and Blankenstein, T.
Journal of Immunology 179 (8): 5534-5542. 15 October 2007

Progressive and controlled development of mouse dendritic cells from Flt3+ CD11b+ progenitors in vitro.
Hieronymus, T., Gust, T.C., Kirsch, R.D., Jorgas, T., Blendinger, G., Goncharenko, M., Supplitt, K., Rose-John, S., Mueller, A.M. and Zenke, M.
Journal of Immunology 174 (5): 2552-2562. 1 January 2005

The human T cell response to myelin oligodendrocyte glycoprotein: a multiple sclerosis family-based study.
Koehler, N.K., Genain, C.P., Giesser, B. and Hauser, S.L.
Journal of Immunology 168 : 5920-5927. 1 June 2002

Journal of Molecular Biology

Plasticity in the contribution of T cell receptor variable region residues to binding of peptide-HLA-A2 complexes.
Smith, S.N., Sommermeyer, D., Piepenbrink, K.H., Blevins, S.J., Bernhard, H., Uckert, W., Baker, B.M. and Kranz, D.M.
Journal of Molecular Biology 425 (22): 4496-4507. 15 November 2013

Journal of Molecular Medicine

Targeting the epidermal growth factor receptor (HER) family by T cell receptor gene-modified T lymphocytes.
Meyerhuber, P., Conrad, H., Staerck, L., Leisegang, M., Busch, D.H., Uckert, W. and Bernhard, H.
Journal of Molecular Medicine 88 (11): 1113-1121. November 2010

Enhanced functionality of T cell receptor-redirected T cells is defined by the transgene cassette.
Leisegang, M., Engels, B., Meyerhuber, P., Kieback, E., Sommermeyer, D., Xue, S.A., Reuß, S., Stauss, H. and Uckert, W.
Journal of Molecular Medicine 86 (5): 573-583. May 2008

Transduction efficiency of MLV but not of HIV-1 vectors is pseudotype dependent on human primary T lymphocytes.
Muehlebach, M.D., Schmitt, I., Steidl, S., Stitz, J., Schweizer, M., Blankenstein, T., Cichutek, K. and Uckert, W.
Journal of Molecular Medicine 81 (12): 801-810. December 2003

Suicide gene therapy for pediatric tumors.
Beltinger, C., Uckert, W. and Debatin, K.M.
Journal of Molecular Medicine 78 (11): 598-612. 1 January 2001

Nonphysiological overexpression of low-density lipoprotein receptors causes pathological intracellular lipid accumulation and the formation of cholesterol and cholesteryl ester crystals in vitro.
Heeren, J., Steinwaerder, D.S., Schnieders, F., Cichon, G., Strauss, M. and Beisiegel, U.
Journal of Molecular Medicine 77 (10): 735-743. October 1999

Journal of Virology

Protective capacity of virus-specific T cell receptor (TCR)-transduced CD8 T cells in vivo.
Mueller, K., von Maessenhausen, A., Aichele, U., Staerck, L., Leisegang, M., Uckert, W. and Pircher, H.
Journal of Virology 86 (19): 10866-10869. October 2012

Construction, rescue, and characterization of vectors derived from ovine atadenovirus.
Loeser, P., Hofmann, C., Both, G.W., Uckert, W. and Hillgenberg, M.
Journal of Virology 77 (22): 11941-11951. November 2003

Biology of ovine adenovirus infection of nonpermissive cells.
Kuemin, D., Hofmann, C., Rudolph, M., Both, G.W. and Loeser, P.
Journal of Virology 76 : 10882-10893. 1 November 2002

Ovine adenovirus vectors overcome preexisting humoral immunity against human adenoviruses in vivo.
Hofmann, C., Loeser, P., Cichon, G., Arnold, W., Both, G.W. and Strauss, M.
Journal of Virology 73 : 6930-6936. 1 August 1999

Methods in Molecular Biology

TCR and CAR engineering of primary human T cells.
Edes, I., Clauss, J., Stahn, R., Sada Japp, A. and Lorenz, F.K.M.
Methods in Molecular Biology 2521 (3): 85-93. 23 June 2022

A method for the generation of TCR retrogenic mice.
Kieback, E., Hilgenberg, E. and Fillatreau, S.
Methods in Molecular Biology 1193 : 117-126. 2014

Molecular Aspects of Medicine

Redirecting T lymphocyte specificity by T cell receptor gene transfer - a new era for immunotherapy.
Engels, B. and Uckert, W.
Molecular Aspects of Medicine 28 (1): 115-142. February 2007

Molecular Cancer Therapeutics

ERK1 as a therapeutic target for dendritic cell vaccination against high-grade gliomas.
Ku, M.C., Edes, I., Bendix, I., Pohlmann, A., Waiczies, H., Prozorovski, T., Günther, M., Martin, C., Pagès, G., Wolf, S.A., Kettenmann, H., Uckert, W., Niendorf, T. and Waiczies, S.
Molecular Cancer Therapeutics 15 (8): 1975-1987. August 2016

Molecular Therapy

CAR T cells with enhanced sensitivity to B cell maturation antigen for the targeting of B cell non-Hodgkin's lymphoma and multiple myeloma.
Bluhm, J., Kieback, E., Marino, S.F., Oden, F., Westermann, J., Chmielewski, M., Abken, H., Uckert, W., Höpken, U.E. and Rehm, A.
Molecular Therapy 26 (8): 1906-1920. 1 August 2018

Genome-wide profiling reveals remarkable parallels between insertion site selection properties of the MLV retrovirus and the piggyBac transposon in primary human CD4(+) T cells.
Gogol-Döring, A., Ammar, I., Gupta, S., Bunse, M., Miskey, C., Chen, W., Uckert, W., Schulz, T.F., Izsvák, Z. and Ivics, Z.
Molecular Therapy 24 (3): 592-606. March 2016

RNAi-mediated TCR knockdown prevents autoimmunity in mice caused by mixed TCR dimers following TCR gene transfer.
Bunse, M., Bendle, G.M., Linnemann, C., Bies, L., Schulz, S., Schumacher, T.N. and Uckert, W.
Molecular Therapy 22 (11): 1983-1991. November 2014

Molecular Therapy - Methods and Clinical Development

Characterization and modulation of anti- αβTCR antibodies and their respective binding sites at the βTCR chain to enrich engineered T cells.
Kierkels, G.J.J., van Diest, E., Hernández-López, P., Scheper, W., de Bruin, A.C.M., Frijlink, E., Aarts-Riemens, T., van Dooremalen, S.F.J., Beringer, D.X., Oostvogels, R., Kramer, L., Straetemans, T., Uckert, W., Sebestyén, Z. and Kuball, J.
Molecular Therapy - Methods and Clinical Development 22 (10): 388-400. 10 September 2021

Molecular and Cellular Biology

Activation-dependent TRAF3 exon 8 alternative splicing is controlled by CELF2 and hnRNP C binding to an upstream intronic element.
Schultz, A.S., Preussner, M., Bunse, M., Karni, R. and Heyd, F.
Molecular and Cellular Biology 37 (7): e.00488-16. April 2017

Nature

Tumour ischaemia by interferon-γ resembles physiological blood vessel regression.
Kammertoens, T., Friese, C., Arina, A., Idel, C., Briesemeister, D., Rothe, M., Ivanov, A., Szymborska, A., Patone, G., Kunz, S., Sommermeyer, D., Engels, B., Leisegang, M., Textor, A., Fehling, H.J., Fruttiger, M., Lohoff, M., Herrmann, A., Yu, H., Weichselbaum, R., Uckert, W., Hübner, N., Gerhardt, H., Beule, D., Schreiber, H. and Blankenstein, T.
Nature 545 (7652): 98-102. 4 May 2017

Nature Biotechnology

Identification of human T-cell receptors with optimal affinity to cancer antigens using antigen-negative humanized mice.
Obenaus, M., Leitão, C., Leisegang, M., Chen, X., Gavvovidis, I., van der Bruggen, P., Uckert, W., Schendel, D.J. and Blankenstein, T.
Nature Biotechnology 33 (4): 402-407. April 2015

Nature Communications

CXCR5 CAR-T cells simultaneously target B cell non-Hodgkin's lymphoma and tumor-supportive follicular T helper cells.
Bunse, M., Pfeilschifter, J., Bluhm, J., Zschummel, M., Joedicke, J.J., Wirges, A., Stark, H., Kretschmer, V., Chmielewski, M., Uckert, W., Abken, H., Westermann, J., Rehm, A. and Höpken, U.E.
Nature Communications 12 (1): 240. 11 January 2021

Nature Immunology

Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma.
Mathas, S., Janz, M., Hummel, F., Hummel, M., Wollert-Wulf, B., Lusatis, S., Anagnostopoulos, I., Lietz, A., Sigvardsson, M., Jundt, F., Joehrens, K., Bommert, K., Stein, H. and Doerken, B.
Nature Immunology 7 (2): 207-215. February 2006

Nature Medicine

Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy.
Bendle, G.M., Linnemann, C., Hooijkaas, A.I., Bies, L., de Witte, M.A., Jorritsma, A., Kaiser, A.D.M., Pouw, N., Debets, R., Kieback, E., Uckert, W., Song, J.Y., Haanen, J.B.A.G. and Schumacher, T.N.M.
Nature Medicine 16 (5): 565-570, 1p following 570. May 2010

OncoImmunology

Transgenic antigen-specific, HLA-A*02:01-allo-restricted cytotoxic T cells recognize tumor-associated target antigen STEAP1 with high specificity.
Schirmer, D., Grünewald, T.G.P., Klar, R., Schmidt, O., Wohlleber, D., Rubio, R.A., Uckert, W., Thiel, U., Bohne, F., Busch, D.H., Krackhardt, A.M., Burdach, S. and Richter, G.H.S.
OncoImmunology 5 (6): e1175795. 25 April 2016

Targeting B-cell neoplasia with T-cell receptors recognizing a CD20-derived peptide on patient-specific HLA.
Mensali, N., Ying, F., Sheng, V.O.Y., Yang, W., Walseng, E., Kumari, S., Fallang, L.E., Kolstad, A., Uckert, W., Malmberg, K.J., Waelchli, S. and Olweus, J.
OncoImmunology 5 (5): e1138199. 18 February 2016

Oncogene

Overexpression of NPM-ALK induces different types of malignant lymphomas in IL-9 transgenic mice.
Lange, K., Uckert, W., Blankenstein, T., Nadrowitz, R., Bittner, C., Renauld, J.C., van Snick, J., Feller, A.C. and Merz, H.
Oncogene 22 (4): 517-527. 30 January 2003

Oncotarget

Interleukin-9 (IL-9) and NPM-ALK each generate mast cell hyperplasia as single 'hit' and cooperate in producing a mastocytosis-like disease in mice.
Merz, H., Kaehler, C., Hoefig, K.P., Branke, B., Uckert, W., Nadrowitz, R., Cerny-Reiterer, S., Herrmann, H., Feller, A.C. and Valent, P.
Oncotarget 1 (2): 104-119. 7 June 2010

PLoS ONE

Isolation and functional characterization of hepatitis B virus-specific T-cell receptors as new tools for experimental and clinical use.
Wisskirchen, K., Metzger, K., Schreiber, S., Asen, T., Weigand, L., Dargel, C., Witter, K., Kieback, E., Sprinzl, M.F., Uckert, W., Schiemann, M., Busch, D.H., Krackhardt, A.M. and Protzer, U.
PLoS ONE 12 (8): e0182936. 8 August 2017

Codon optimization of the human papillomavirus E7 oncogene induces a CD8(+) T cell response to a cryptic epitope not harbored by wild-type E7.
Lorenz, F.K.M., Wilde, S., Voigt, K., Kieback, E., Mosetter, B., Schendel, D.J. and Uckert, W.
PLoS ONE 10 (3): e0121633. 23 March 2015

MHC multimer-guided and cell culture-independent isolation of functional T cell receptors from single cells facilitates TCR identification for immunotherapy.
Dössinger, G., Bunse, M., Bet, J., Albrecht, J., Paszkiewicz, P.J., Weißbrich, B., Schiedewitz, I., Henkel, L., Schiemann, M., Neuenhahn, M., Uckert, W. and Busch, D.H.
PLoS ONE 8 (4): e61384. 26 April 2013

Pharmacology & Therapeutics

Retrovirus-mediated gene transfer in cancer therapy.
Uckert, W. and Walther, W.
Pharmacology & Therapeutics 63 : 323-347. 1 January 1994

Proceedings of the National Academy of Sciences of the United States of America

A safeguard eliminates T cell receptor gene-modified autoreactive T cells after adoptive transfer.
Kieback, E., Charo, J., Sommermeyer, D., Blankenstein, T. and Uckert, W.
Proceedings of the National Academy of Sciences of the United States of America 105 (2): 623-628. 15 January 2008

Herpes simplex virus thymidine kinase/ganciclovir-induced apoptosis involves ligand-independent death receptor aggregation and activation of caspases.
Beltinger, C., Fulda, S., Kammertoens, T., Meyer, E., Uckert, W. and Debatin, K.M.
Proceedings of the National Academy of Sciences of the United States of America 96 : 8699-8704. 20 July 1999

Science Translational Medicine

TCR-ligand k(off) rate correlates with the protective capacity of antigen-specific CD8(+) T cells for adoptive transfer.
Nauerth, M., Weissbrich, B., Knall, R., Franz, T., Dössinger, G., Bet, J., Paszkiewicz, P.J., Pfeifer, L., Bunse, M., Uckert, W., Holtappels, R., Gillert-Marien, D., Neuenhahn, M., Krackhardt, A., Reddehase, M.J., Riddell, S.R. and Busch, D.H.
Science Translational Medicine 5 (192): 192ra87. 3 July 2013

Scientific Reports

Proteasomes generate spliced epitopes by two different mechanisms and as efficiently as non-spliced epitopes.
Ebstein, F., Textoris-Taube, K., Keller, C., Golnik, R., Vigneron, N., Van den Eynde, B.J., Schuler-Thurner, B., Schadendorf, D., Lorenz, F.K.M., Uckert, W., Urban, S., Lehmann, A., Albrecht-Koepke, N., Janek, K., Henklein, P., Niewienda, A., Kloetzel, P.M. and Mishto, M.
Scientific Reports 6 : 24032. 6 April 2016

Stem Cells

The antitumorigenic response of neural precursors depends on subventricular proliferation and age.
Walzlein, J.H., Synowitz, M., Engels, B., Markovic, D.S., Gabrusiewicz, K., Nikolaev, E., Yoshikawa, K., Kaminska, B., Kempermann, G., Uckert, W., Kaczmarek, L., Kettenmann, H. and Glass, R.
Stem Cells 26 (11): 2945-2954. November 2008

Vaccine

Recombinant ovine atadenovirus induces a strong and sustained T cell response against the hepatitis C virus NS3 antigen in mice.
Wuest, T., Both, G.W., Prince, A.M., Hofmann, C. and Loeser, P.
Vaccine 22 (21-22): 2717-2721. 1 January 2004

Verhandlungen der Deutschen Gesellschaft fuer Pathologie

Die Ueberexpression von NPM-ALK in haematopoietischen Stammzellen induziert verschiedene maligne Non-Hodgkin-Lymphome in der IL-9 transgenen Maus [Overexpression of NPM-ALK induces different types of malignant lymphomas in IL-9 transgenic mice].
Merz, H., Lange, K., Nadrowitz, R., Uckert, W., Blankenstein, T. and Feller, A.C.
Verhandlungen der Deutschen Gesellschaft fuer Pathologie 87 : 224-231. 1 January 2003

Virology

Factors influencing subcellular localization of the human papillomavirus L2 minor structural protein.
Kieback, E. and Mueller, M.
Virology 345 (1): 199-208. 5 February 2006

Identification of an ovine atadenovirus gene whose product activates the viral E2 promoter: possible involvement of E2F-1.
Kuemin, D., Hofmann, C., Uckert, W., Both, G.W. and Loeser, P.
Virology 318 (1): 79-89. 5 January 2004

Lentiviral vectors pseudotyped with envelope glycoproteins derived from gibbon ape leukemia virus and murine leukemia virus 10A1.
Stitz, J., Buchholz, C.J., Engelstaedter, M., Uckert, W., Bloemer, U., Schmitt, I. and Cichutek, K.
Virology 273 (1): 16-20. 1 January 2000

Modulation of moloney leukemia virus long terminal repeat transcriptionalactivity by the murine CD4 silencer in retroviral vectors.
Indraccolo, S., Minuzzo, S., Habeler, W., Zamarchi, R., Fregonese, A., Guenzburg, W.H., Salmons, B., Uckert, W., Chieco-Bianchi, L. and Amadori, A.
Virology 276 : 83-92. 1 January 2000

eLife

Domain-swapped T cell receptors improve the safety of TCR gene therapy.
Bethune, M.T., Gee, M.H., Bunse, M., Lee, M.S., Gschweng, E.H., Pagadala, M.S., Zhou, J., Cheng, D., Heath, J.R., Kohn, D.B., Kuhns, M.S., Uckert, W. and Baltimore, D.
eLife 5 : e19095. 8 November 2016