2016
Pharmacological interference with protein-protein interactions of A-kinase anchoring proteins as a strategy for the treatment of disease.
Deák, V.A. and Klussmann, E.
Current Drug Targets 17
(10): 1147-1171.
1 August 2016
2015
Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domains.
Bolger, G.B. and Dunlop, A.J. and Meng, D. and Day, J.P. and Klussmann, E. and Baillie, G.S. and Adams, D.R. and Houslay, M.D.
Cellular Signalling 27
(4): 756-769.
April 2015
Regulation of sarcoplasmic reticulum Ca(2+) ATPase 2 (SERCA2) activity by phosphodiesterase 3A (PDE3A) in human myocardium: phosphorylation-dependent interaction of PDE3A1 with SERCA2.
Ahmad, F. and Shen, W. and Vandeput, F. and Szabo-Fresnais, N. and Krall, J. and Degerman, E. and Goetz, F. and Klussmann, E. and Movsesian, M. and Manganiello, V.
Journal of Biological Chemistry 290
(11): 6763-6776.
13 March 2015
Screening for small molecule disruptors of AKAP-PKA interactions.
Schächterle, C. and Christian, F. and Fernandes, J.M.P. and Klussmann, E.
Methods in Molecular Biology 1294
: 151-166.
2 March 2015
Keeping those telomeres short! an innovative intratumoral long-term drug delivery system.
Laster, B.H. and Isaacson, C. and Perets, E. and Msamra, M. and Priel, E. and Kalef-Ezra, J. and Kost, J.
Journal of Cancer Research and Clinical Oncology 141
(1): 23-34.
January 2015
2014
The crystal structure of the RhoA-AKAP-Lbc DH-PH domain complex.
Abdul Azeez, K.R. and Knapp, S. and Fernandes, J.M.P. and Klussmann, E. and Elkins, J.M.
Biochemical Journal 464
(2): 231-239.
1 December 2014
Flexible, polymer-supported synthesis of sphingosine derivatives provides ceramides with enhanced biological activity.
El-Dahshan, A. and Al-Gharabli, S.I. and Radetzki, S. and Al-Tel, T.H. and Kumar, P. and Rademann, J.
Bioorganic and Medicinal Chemistry 22
(19): 5506-5512.
1 October 2014
G protein-coupled estrogen receptor 1 (GPER) mediates relaxation of coronary arteries via cAMP/PKA-dependent activation of MLCP.
Yu, X. and Li, F. and Klussmann, E. and Stallone, J.N. and Han, G.
American Journal of Physiology Endocrinology and Metabolism 307
(4): E398-E407.
15 August 2014
2013
Highly functionalized terpyridines as competitive inhibitors of AKAP-PKA interactions.
Schäfer, G. and Milić, J and Eldahshan, A and Götz, F. and Zühlke, K. and Schillinger, C. and Kreuchwig, A. and Elkins, J.M. and Abdul Azeez, K.R.A. and Oder, A. and Moutty, M.C. and Masada, N. and Beerbaum, M. and Schlegel, B. and Niquet, S. and Schmieder, P. and Krause, G. and von Kries, J.P. and Cooper, D.M.F. and Knapp, S. and Rademann, J. and Rosenthal, W. and Klussmann, E.
Angewandte Chemie International Edition 52
(46): 12187-12191.
11 November 2013
AKAPS act in a two-step mechanism of memory acquisition.
Scheunemann, L. and Skroblin, P. and Hundsrucker, C. and Klussmann, E. and Efetova, M. and Schwärzel, M.
Journal of Neuroscience 33
(44): 17422-17428.
30 October 2013
Culturing primary rat inner medullary collecting duct cells.
Faust, D. and Geelhaar, A. and Eisermann, B. and Eichhorst, J. and Wiesner, B. and Rosenthal, W. and Klussmann, E.
Journal of Visualized Experiments
(76): e50366.
21 June 2013
Small-molecule screening identifies modulators of aquaporin-2 trafficking.
Bogum, J. and Faust, D. and Zühlke, K. and Eichhorst, J. and Moutty, M.C. and Furkert, J. and Eldahshan, A. and Neuenschwander, M. and von Kries, J.P. and Wiesner, B. and Trimpert, C. and Deen, P.M. and Valenti, G. and Rosenthal, W. and Klussmann, E.
Journal of the American Society of Nephrology 24
(5): 744-758.
April 2013
2012
Mechanism for targeting the A-kinase anchoring protein AKAP18δ to the membrane.
Horner, A. and Goetz, F. and Tampe, R. and Klussmann, E. and Pohl, P.
Journal of Biological Chemistry 287
(51): 42495-42501.
14 December 2012
A key phosphorylation site in AC8 mediates regulation of Ca2+-dependent cAMP dynamics by an AC8-AKAP79-PKA signalling complex.
Willoughby, D. and Halls, M.L. and Everett, K.L. and Skroblin, P. and Klussmann, E. and Cooper, D.M.F.
Journal of Cell Science 125
(Pt 23): 5850-5859.
1 December 2012
Vasopressin increases S261 phosphorylation in AQP2-P262L, a mutant in recessive nephrogenic diabetes insipidus.
Trimpert, C. and van den Berg, D.T.M. and Fenton, R.A. and Klussmann, E. and Deen, P.M.T.
Nephrology Dialysis Transplantation 27
(12): 4389-4397.
December 2012
The protease-activated receptor 1 possesses a functional and cleavable signal peptide which is necessary for receptor expression.
Zampatis, D.E. and Rutz, C. and Furkert, J. and Schmidt, A. and Wuestenhagen, D. and Kubick, S. and Tsopanoglou, N.E. and Schuelein, R.
FEBS Letters 586
(16): 2351-2359.
31 May 2012
A-kinase anchoring proteins as potential drug targets.
Troeger, J. and Moutty, M.C. and Skroblin, P. and Klussmann, E.
British Journal of Pharmacology 166
(2): 420-433.
May 2012
Direct binding between Orai1 and AC8 mediates dynamic interplay between Ca2+ and cAMP signaling.
Willoughby, D. and Everett, K.L. and Halls, M.L. and Pacheco, J. and Skroblin, P. and Vaca, L. and Klussmann, E. and Cooper, D.M.
Science Signaling 5
(219): ra29.
10 April 2012
Functional significance of cleavable signal peptides of G protein-coupled receptors.
Schuelein, R. and Westendorf, C. and Krause, G. and Rosenthal, W.
European Journal of Cell Biology 91
(4): 294-299.
April 2012
2011
Spinophilin regulates central angiotensin II-mediated effect on blood pressure.
da Costa Goncalves, A.C. and Fontes, M.A. and Klussmann, E. and Qadri, F. and Janke, J. and Gollasch, M. and Schleifenbaum, J. and Mueller, D. and Jordan, J. and Tank, J. and Luft, F.C. and Gross, V.
Journal of Molecular Medicine 89
(12): 1219-1229.
December 2011
Inhibition of the biosynthesis of the human endothelin B receptor by the cyclodepsipeptide cotransin.
Westendorf, C. and Schmidt, A. and Coin, I. and Furkert, J. and Ridelis, I. and Zampatis, D. and Rutz, C. and Wiesner, B. and Rosenthal, W. and Beyermann, M. and Schuelein, R.
Journal of Biological Chemistry 286
(41): 35588-35600.
14 October 2011
Interaction between LIS1 and PDE4, and its role in cytoplasmic dynein function.
Murdoch, H. and Vadrevu, S. and Prinz, A. and Dunlop, A.J. and Klussmann, E. and Bolger, G.B. and Norman, J.C. and Houslay, M.D.
Journal of Cell Science 124
(Pt 13): 2253-2266.
1 July 2011
Elucidation of a structural basis for the inhibitor-driven, p62 (SQSTM1)-dependent intracellular redistribution of cAMP phosphodiesterase-4A4 (PDE4A4).
Day, J.P. and Lindsay, B. and Riddell, T. and Jiang, Z. and Allcock, R.W. and Abraham, A. and Sookup, S. and Christian, F. and Bogum, J. and Martin, E.K. and Rae, R.L. and Anthony, D. and Rosair, G.M. and Houslay, D.M. and Huston, E. and Baillie, G.S. and Klussmann, E. and Houslay, M.D. and Adams, D.R.
Journal of Medicinal Chemistry 54
(9): 3331-3347.
12 May 2011
Small molecule AKAP/PKA interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes.
Christian, F. and Szaszak, M. and Friedl, S. and Drewianka, S. and Lorenz, D. and Goncalves, A. and Furkert, J. and Vargas, C. and Schmieder, P. and Goetz, F. and Zuehlke, K. and Moutty, M. and Goettert, H. and Joshi, M. and Reif, B. and Haase, H. and Morano, I. and Grossmann, S. and Klukovits, A. and Verli, J. and Gaspar, R. and Noack, C. and Bergmann, M. and Kass, R. and Hampel, K. and Kashin, D. and Genieser, H.G. and Herberg, F.W. and Willoughby, D. and Cooper, D.M. and Baillie, G.S. and Houslay, M.D. and von Kries, J.P. and Zimmermann, B. and Rosenthal, W. and Klussmann, E.
Journal of Biological Chemistry 286
(11): 9079-9096.
18 March 2011
2010
Routes of epithelial water flow: aquaporins versus cotransporters.
Mollajew, R. and Zocher, F. and Horner, A. and Wiesner, B. and Klussmann, E. and Pohl, P.
Biophysical Journal 99
(11): 3647-3656.
1 December 2010
The pseudo signal peptide of the corticotropin-releasing factor receptor type 2a decreases receptor expression and prevents Gi-mediated inhibition of adenylyl cyclase activity.
Schulz, K. and Rutz, C. and Westendorf, C. and Ridelis, I. and Vogelbein, S. and Furkert, J. and Schmidt, A. and Wiesner, B. and Schuelein, R.
Journal of Biological Chemistry 285
(43): 32878-32887.
22 October 2010
Reciprocal regulation of aquaporin-2 abundance and degradation by protein kinase A and p38-MAP kinase.
Nedvetsky, P.I. and Tabor, V. and Tamma, G. and Beulshausen, S. and Skroblin, P. and Kirschner, A. and Mutig, K. and Boltzen, M. and Petrucci, O. and Vossenkaemper, A. and Wiesner, B. and Bachmann, S. and Rosenthal, W. and Klussmann, E.
Journal of the American Society of Nephrology 21
(10): 1645-1656.
October 2010
Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK.
Li, X. and Vadrevu, S. and Dunlop, A. and Day, J. and Advant, N. and Troeger, J. and Klussmann, E. and Jaffrey, E. and Hay, R.T. and Adams, D.R. and Houslay, M.D. and Baillie, G.S.
Biochemical Journal 428
(1): 55-65.
15 May 2010
Glycogen synthase kinase 3β interaction protein functions as an A-kinase anchoring protein.
Hundsrucker, C. and Skroblin, P. and Christian, F. and Zenn, M. and Popara, V. and Joshi, M. and Eichhorst, J. and Wiesner, B. and Herberg, F.W. and Reif, B. and Rosenthal, W. and Klussmann, E.
Journal of Biological Chemistry 285
(8): 5507-5521.
19 February 2010
Mechanisms of protein kinase A anchoring.
Skroblin, P. and Grossmann, S. and Schaefer, G. and Rosenthal, W. and Klussmann, E.
International Review of Cell and Molecular Biology 283
(C): 235-330.
2010
2009
Structural determinants for selective recognition of peptide ligands for endothelin receptor subtypes ETA and ETB.
Laettig, J. and Oksche, A. and Beyermann, M. and Rosenthal, W. and Krause, G.
Journal of Peptide Science 15
(7): 479-491.
July 2009
MEK1 binds directly to βarrestin1, influencing both its phosphorylation by ERK and the timing of its isoprenaline-stimulated internalization.
Meng, D. and Lynch, M.J. and Huston, E. and Beyermann, M. and Eichhorst, J. and Adams, D.R. and Klussmann, E. and Houslay, M.D. and Baillie, G.S.
Journal of Biological Chemistry 284
(17): 11425-1135.
24 April 2009
The sequence after the signal peptide of the g protein-coupled endothelin B receptor is required for efficient translocon gating at the endoplasmic reticulum membrane.
Alken, M. and Schmidt, A. and Rutz, C. and Furkert, J. and Kleinau, G. and Rosenthal, W. and Schuelein, R.
Molecular Pharmacology 75
(4): 801-811.
April 2009
Regulation of aquaporin-2 trafficking.
Nedvetsky, P.I. and Tamma, G. and Beulshausen, S. and Valenti, G. and Rosenthal, W. and Klussmann, E.
Handbook of Experimental Pharmacology 190
(II): 133-157.
2009
2008
Compartmentalized cAMP signalling in regulated exocytic processes in non-neuronal cells.
Szaszak, M. and Christian, F. and Rosenthal, W. and Klussmann, E.
Cellular Signalling 20
(4): 590-601.
April 2008
Derlin-1 and p97/valosin-containing protein mediate the endoplasmic reticulum-associated degradation of human V2 vasopressin receptors.
Schwieger, I. and Lautz, K. and Krause, E. and Rosenthal, W. and Wiesner, B. and Hermosilla, R.
Molecular Pharmacology 73
(3): 697-708.
March 2008
Direct AKAP-mediated protein-protein interactions as potential drug targets.
Hundsrucker, C. and Klussmann, E.
Handbook of Experimental Pharmacology 186
: 483-503.
2008
2007
1H NMR structural and functional characterisation of a cAMP-specific phosphodiesterase-4D5 (PDE4D5) N-terminal region peptide that disrupts PDE4D5 interaction with the signalling scaffold proteins, beta-arrestin and RACK1.
Smith, K.J. and Baillie, G.S. and Hyde, E.I. and Li, X. and Houslay, T.M. and McCahill, A. and Dunlop, A.J. and Bolger, G.B. and Klussmann, E. and Adams, D.R. and Houslay, M.D.
Cellular Signalling 19
(12): 2612-2624.
December 2007
AKAP complex regulates Ca2+ re-uptake into heart sarcoplasmic reticulum.
Lygren, B. and Carlson, C.R. and Santamaria, K. and Lissandron, V. and McSorley, T. and Litzenberg, J. and Lorenz, D. and Wiesner, B. and Rosenthal, W. and Zaccolo, M. and Tasken, K. and Klussmann, E.
EMBO Reports 8
(11): 1061-1067.
1 November 2007
Microtubules are needed for the perinuclear positioning of aquaporin-2 after its endocytic retrieval in renal principal cells.
Vossenkaemper, A. and Nedvetsky, P.I. and Wiesner, B. and Furkert, J. and Rosenthal, W. and Klussmann, E.
American Journal of Physiology Cell Physiology 293
(3): C1129-C1138.
11 September 2007
Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes to dissociation by elevated intracellular cAMP levels.
Murdoch, H. and Mackie, S. and Collins, D.M. and Hill, E.V. and Bolger, G.B. and Klussmann, E. and Porteous, D.J. and Millar, J.K. and Houslay, M.D.
Journal of Neuroscience 27
(35): 9513-9524.
29 August 2007
Rescue of a nephrogenic diabetes insipidus-causing vasopressin V2 receptor mutant by cell-penetrating peptides.
Oueslati, M. and Hermosilla, R. and Schoenenberger, E. and Oorschot, V. and Beyermann, M. and Wiesner, B. and Schmidt, A. and Klumperman, J. and Rosenthal, W. and Schuelein, R.
Journal of Biological Chemistry 282
(28): 20676-20685.
13 July 2007
p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway.
Sachs, B.D. and Baillie, G.S. and McCall, J.R. and Passino, M.A. and Schachtrup, C. and Wallace, D.A. and Dunlop, A.J. and MacKenzie, K.F. and Klussmann, E. and Lynch, M.J. and Sikorski, S.L. and Nuriel, T. and Tsigelny, I. and Zhang, J. and Houslay, M.D. and Chao, M.V. and Akassoglou, K.
Journal of Cell Biology 177
(6): 1119-1132.
18 June 2007
Mapping binding sites for the PDE4D5 cAMP-specific phosphodiesterase to the N- and C-domains of beta-arrestin using spot-immobilized peptide arrays.
Baillie, G.S. and Adams, D.R. and Bhari, N. and Houslay, T.M. and Vadrevu, S. and Meng, D. and Li, X. and Dunlop, A. and Milligan, G. and Bolger, G.B. and Klussmann, E. and Houslay, M.D.
Biochemical Journal 404
(1): 71-80.
15 May 2007
A role of myosin Vb and Rab11-FIP2 in the aquaporin-2 shuttle.
Nedvetsky, P.I. and Stefan, E. and Frische, S. and Santamaria, K. and Wiesner, B. and Valenti, G. and Hammer, J.A. and Nielsen, S. and Goldenring, J.R. and Rosenthal, W. and Klussmann, E.
Traffic 8
(2): 110-123.
February 2007
Compartmentalization of cAMP-dependent signaling by phosphodiesterase-4D is involved in the regulation of vasopressin-mediated water reabsorption in renal principal cells.
Stefan, E. and Wiesner, B. and Baillie, G.S. and Mollajew, R. and Henn, V. and Lorenz, D. and Furkert, J. and Santamaria, K. and Nedvetsky, P.I. and Hundsrucker, C. and Beyermann, M. and Krause, E. and Pohl, P. and Gall, I. and MacIntyre, A.N. and Bachmann, S. and Houslay, M.D. and Rosenthal, W. and Klussmann, E.
Journal of the American Society of Nephrology 18
(1): 199-212.
January 2007
Protein-Protein-Interaktionen als Ziel fuer neue Pharmaka : EU-Projekt thera-cAMP.
Klussmann, E.
BIOforum 2
: 32-34.
2007
Protein-protein interactions as target for new therapeutic molecules.
Klussmann, E.
BIOforum Europe 3
: 18-19.
2007
2006
The corticotropin-releasing factor receptor type 2a contains an N-terminal pseudo signal peptide.
Rutz, C. and Renner, A. and Alken, M. and Schulz, K. and Beyermann, M. and Wiesner, B. and Rosenthal, W. and Schuelein, R.
Journal of Biological Chemistry 281
(34): 24910-24921.
25 August 2006
Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, beta-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5.
Bolger, G.B. and Baillie, G.S. and Li, X. and Lynch, M.J. and Herzyk, P. and Mohamed, A. and Mitchell, L.H. and McCahill, A. and Hundsrucker, C. and Klussmann, E. and Adams, D.R. and Houslay, M.D.
Biochemical Journal 398
(1): 23-36.
15 August 2006
Peptides for disruption of PKA anchoring.
Hundsrucker, C. and Rosenthal, W. and Klussmann, E.
Biochemical Society Transactions 34
(Pt 4): 472-473.
1 August 2006
First international meeting on anchored cAMP signaling pathways, Biomedical Campus, Berlin-Buch, Germany, 15-16 October 2005.
Klussmann, E.
European Journal of Cell Biology 85
(7): 581-584.
5 July 2006
Spatial organisation of AKAP18 and PDE4 isoforms in renal collecting duct principal cells.
McSorley, T. and Stefan, E. and Henn, V. and Wiesner, B. and Baillie, G.S. and Houslay, M.D. and Rosenthal, W. and Klussmann, E.
European Journal of Cell Biology 85
(7): 673-678.
5 July 2006
High-affinity AKAP7delta-protein kinase A interaction yields novel protein kinase A-anchoring disruptor peptides.
Hundsrucker, C. and Krause, G. and Beyermann, M. and Prinz, A. and Zimmermann, B. and Diekmann, O. and Lorenz, D. and Stefan, E. and Nedvetsky, P. and Dathe, M. and Christian, F. and McSorley, T. and Krause, E. and McConnachie, G. and Herberg, F.W. and Scott, J.D. and Rosenthal, W. and Klussmann, E.
Biochemical Journal 396
(2): 297-306.
1 June 2006
Endothelin A and endothelin B receptors differ in their ability to stimulate ERK1/2 activation.
Grantcharova, E. and Reusch, H.P. and Beyermann, M. and Rosenthal, W. and Oksche, A.
Experimental Biology and Medicine 231
(6): 757-760.
June 2006
N-terminal proteolysis of the endothelin B receptor abolishes its ability to induce EGF receptor transactivation and contractile protein expression in vascular smooth muscle cells.
Grantcharova, E. and Reusch, H.P. and Grossmann, S. and Eichhorst, J. and Krell, H.W. and Beyermann, M. and Rosenthal, W. and Oksche, A.
Arteriosclerosis Thrombosis and Vascular Biology 26
(6): 1288-1296.
June 2006
AKAP7.
Klussmann, E. and Rosenthal, W.
UCSD Nature Molecule Pages
4 April 2006
2005
Compartmentalized cAMP signalling regulates vasopressin-mediated water reabsorption by controlling aquaporin-2.
Henn, V. and Stefan, E. and Baillie, G.S. and Houslay, M.D. and Rosenthal, W. and Klussmann, E.
Biochemical Society Transactions 33
(Pt 6): 1316-1318.
December 2005
Arrestin-independent internalization and recycling of the urotensin receptor contribute to long-lasting urotensin II-mediated vasoconstriction.
Giebing, G. and Toelle, M. and Juergensen, J. and Eichhorst, J. and Furkert, J. and Beyermann, M. and Neuschaefer-Rube, F. and Rosenthal, W. and Zidek, W. and van der Giet, M. and Oksche, A.
Circulation Research 97
(7): 707-715.
30 September 2005
RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta2-adrenergic receptor to activation of ERK in HEK293B2 cells.
Lynch, M.J. and Baillie, G.S. and Mohamed, A. and Li, X. and Maisonneuve, C. and Klussmann, E. and van Heeke, G. and Houslay, M.D.
Journal of Biological Chemistry 280
(39): 33178-33189.
30 September 2005
The hydrophobic amino acid residues in the membrane-proximal C tail of the G protein-coupled vasopressin V2 receptor are necessary for transport-competent receptor folding.
Thielen, A. and Oueslati, M. and Hermosilla, R. and Krause, G. and Oksche, A. and Rosenthal, W. and Schuelein, R.
FEBS Letters 579
(23): 5227-5235.
26 September 2005
Actin remodeling requires ERM function to facilitate AQP2 apical targeting.
Tamma, G. and Klussmann, E. and Oehlke, J. and Krause, E. and Rosenthal, W. and Svelto, M. and Valenti, G.
Journal of Cell Science 118
(Pt 16): 3623-3630.
15 August 2005
The signal peptide of the rat corticotropin-releasing factor receptor 1 promotes receptor expression but is not essential for establishing a functional receptor.
Alken, M. and Rutz, C. and Koechl, R. and Donalies, U. and Oueslati, M. and Furkert, J. and Wietfeld, D. and Hermosilla, R. and Scholz, A. and Beyermann, M. and Rosenthal, W. and Schuelein, R.
Biochemical Journal 390
(Pt 2): 455-464.
2005
2004
Disease-causing V(2) vasopressin receptors are retained in different compartments of the early secretory pathway.
Hermosilla, R. and Oueslati, M. and Donalies, U. and Schoenenberger, E. and Krause, E. and Oksche, A. and Rosenthal, W. and Schuelein, R.
Traffic 5
(12): 993-1005.
December 2004
Pharmacochaperones post-translationally enhance cell surface expression by increasing conformational stability of wild-type and mutant vasopressin V2 receptors.
Wueller, S. and Wiesner, B. and Loeffler, A. and Furkert, J. and Krause, G. and Hermosilla, R. and Schaefer, M. and Schuelein, R. and Rosenthal, W. and Oksche, A.
Journal of Biological Chemistry 279
(45): 47254-47263.
5 November 2004
Fluorescence resonance energy transfer analysis reveals the existence of endothelin-A and endothelin-B receptor homodimers.
Gregan, B. and Schaefer, M. and Rosenthal, W. and Oksche, A.
Journal of Cardiovascular Pharmacology 44
(Suppl 1): S30-S33.
November 2004
Ligand-dependent differences in the internalization of endothelin A and endothelin B receptor heterodimers.
Gregan, B. and Juergensen, J. and Papsdorf, G. and Furkert, J. and Schaefer, M. and Beyermann, M. and Rosenthal, W. and Oksche, A.
Journal of Biological Chemistry 279
(26): 27679-27687.
25 June 2004
Identification of a novel A-kinase anchoring protein 18 isoform and evidence for its role in the vasopressin-induced aquaporin-2 shuttle in renal principal cells.
Henn, V. and Edemir, B. and Stefan, E. and Wiesner, B. and Lorenz, D. and Theilig, F. and Schmitt, R. and Vossebein, L. and Tamma, G. and Beyermann, M. and Krause, E. and Herberg, F.W. and Valenti, G. and Bachmann, S. and Rosenthal, W. and Klussmann, E.
Journal of Biological Chemistry 279
(25): 26654-26665.
18 June 2004
Aquaporin-1, nothing but a water channel.
Tsunoda, S.P. and Wiesner, B. and Lorenz, D. and Rosenthal, W. and Pohl, P.
Journal of Biological Chemistry 279
(12): 11364-11367.
19 March 2004
2003
The prostaglandin E2 analogue sulprostone antagonizes vasopressin-induced antidiuresis through activation of Rho.
Tamma, G. and Wiesner, B. and Furkert, J. and Hahm, D. and Oksche, A. and Schaefer, M. and Valenti, G. and Rosenthal, W. and Klussmann, E.
Journal of Cell Science 116
(Pt 16): 3285-3294.
15 August 2003
Renal expression of sodium transporters and aquaporin-2 in hypothyroid rats.
Schmitt, R. and Klussmann, E. and Kahl, T. and Ellison, D.H. and Bachmann, S.
American Journal of Physiology Renal Physiology 284
(5): F1097-F1104.
May 2003
cAMP-induced AQP2 translocation is associated with RhoA inhibition through RhoA phosphorylation and interaction with RhoGDI.
Tamma, G. and Klussmann, E. and Procino, G. and Svelto, M. and Rosenthal, W. and Valenti, G.
Journal of Cell Science 116
(Pt 8): 1519-1525.
15 April 2003
Cyclic AMP is sufficient for triggering the exocytic recruitment of aquaporin-2 in renal epithelial cells.
Lorenz, D. and Krylov, A. and Hahm, D. and Hagen, V. and Rosenthal, W. and Pohl, P. and Maric, K.
EMBO Reports 4
(1): 88-93.
January 2003
Osmolality and solute composition are strong regulators of AQP2 expression in renal principal cells.
Storm, R. and Klussmann, E. and Geelhaar, A. and Rosenthal, W. and Maric, K.
American Journal of Physiology Renal Physiology 284
(1): F189-F198.
January 2003
2002
The extracellular N terminus of the endothelin B (ETB) receptor is cleaved by a metalloprotease in an agonist-dependent process.
Grantcharova, E. and Furkert, J. and Reusch, H.P. and Krell, H.W. and Papsdorf, G. and Beyermann, M. and Schulein, R. and Rosenthal, W. and Oksche, A.
Journal of Biological Chemistry 277
(46): 43933-43941.
15 November 2002
Functional involvement of VAMP/synaptobrevin-2 in cAMP-stimulated aquaporin 2 translocation in renal collecting duct cells.
Gouraud, S. and Laera, A. and Calamita, G. and Carmosino, M. and Procino, G. and Rossetto, O. and Mannucci, R. and Rosenthal, W. and Svelto, M. and Valenti, G.
Journal of Cell Science 115
(Pt 18): 3667-3674.
15 September 2002
Cell-biologic and functional analyses of five new Aquaporin-2 missense mutations that cause recessive nephrogenic diabetes insipidus.
Marr, N. and Bichet, D.G. and Hoefs, S. and Savelkoul, P.J. and Konings, I.B. and De Mattia, F. and Graat, M.P. and Arthus, M.F. and Lonergan, M. and Fujiwara, T.M. and Knoers, N.V. and Landau, D. and Balfe, W.J. and Oksche, A. and Rosenthal, W. and Mueller, D. and Van Os, C.H. and Deen, P.M.
Journal of the American Society of Nephrology 13
(9): 2267-2277.
September 2002
The signal peptide of the G protein-coupled human endothelin B receptor is necessary for translocation of the N-terminal tail across the endoplasmic reticulum membrane.
Koechl, R. and Alken, M. and Rutz, C. and Krause, G. and Oksche, A. and Rosenthal, W. and Schuelein, R.
Journal of Biological Chemistry 277
(18): 16131-16138.
3 May 2002
Variant amino acids in the extracellular loops of murine and human vasopressin V2 receptors account for differences in cell surface expression and ligand affinity.
Oksche, A. and Leder, G. and Valet, S. and Platzer, M. and Hasse, K. and Geist, S. and Krause, G. and Rosenthal, A. and Rosenthal, W.
Molecular Endocrinology 16
(4): 799-813.
April 2002
Heteroligomerization of an Aquaporin-2 mutant with wild-type Aquaporin-2 and their misrouting to late endosomes/lysosomes explains dominant nephrogenic diabetes insipidus.
Marr, N. and Bichet, D.G. and Lonergan, M. and Arthus, M.F. and Jeck, N. and Seyberth, H.W. and Rosenthal, W. and van Os, C.H. and Oksche, A. and Deen, P.M.
Human Molecular Genetics 11
(7): 779-789.
2002
2001
Rho inhibits cAMP-induced translocation of aquaporin-2 into the apical membrane of renal cells.
Tamma, G. and Klussmann, E. and Maric, K. and Aktories, K. and Svelto, M. and Rosenthal, W. and Valenti, G.
American Journal of Physiology Renal Physiology 281
(6): F1092-F1101.
December 2001
Ht31: the first protein kinase A anchoring protein to integrate protein kinase A and Rho signaling.
Klussmann, E. and Edemir, B. and Pepperle, B. and Tamma, G. and Henn, V. and Klauschenz, E. and Hundsrucker, C. and Maric, K. and Rosenthal, W.
FEBS Letters 507
(3): 264-268.
2 November 2001
Role and identification of protein kinase A anchoring proteins in vasopressin-mediated aquaporin-2 translocation.
Klussmann, E. and Rosenthal, W.
Kidney International 60
(2): 446-449.
August 2001
An inhibitory role of Rho in the vasopressin-mediated translocation of aquaporin-2 into cell membranes of renal principal cells.
Klussmann, E. and Tamma, G. and Lorenz, D. and Wiesner, B. and Maric, K. and Hofmann, F. and Aktories, K. and Valenti, G. and Rosenthal, W.
Journal of Biological Chemistry 276
(23): 20451-20457.
8 June 2001
Cell volume kinetics of adherent epithelial cells measured by laser scanning reflection microscopy: determination of water permeability changes of renal principal cells.
Maric, K. and Wiesner, B. and Lorenz, D. and Klussmann, E. and Betz, T. and Rosenthal, W.
Biophysical Journal 80
(4): 1783-1790.
April 2001
Functional rescue of the nephrogenic diabetes insipidus-causing vasopressin V2 receptor mutants G185C and R202C by a second site suppressor mutation.
Schuelein, R. and Zuehlke, K. and Krause, G. and Rosenthal, W.
Journal of Biological Chemistry 276
(11): 8384-8392.
16 March 2001
2000
Evidence for downregulation of the endothelin-B-receptor by the use of fluorescent endothelin-1 and a fusion protein consisting of the endothelin-B-receptor and the green fluorescent protein.
Oksche, A. and Boese, G. and Horstmeyer, A. and Papsdorf, G. and Furkert, J. and Beyermann, M. and Bienert, M. and Rosenthal, W.
Journal of Cardiovascular Pharmacology 36
(5 Suppl 1): S44-S47.
November 2000
Vasopressin-induced von Willebrand factor secretion from endothelial cells involves V2 receptors and cAMP.
Kaufmann, J.E. and Oksche, A. and Wollheim, C.B. and Guenther, G. and Rosenthal, W. and Vischer, U.M.
Journal of Clinical Investigation 106
(1): 107-116.
July 2000
Late endosomal/lysosomal targeting and lack of recycling of the ligand-occupied endothelin B receptor.
Oksche, A. and Boese, G. and Horstmeyer, A. and Furkert, J. and Beyermann, M. and Bienert, M. and Rosenthal, W.
Molecular Pharmacology 57
(6): 1104-1113.
June 2000
Molecular and conformational features of a transport-relevant domain in the C-terminal tail of the vasopressin V(2) receptor.
Krause, G. and Hermosilla, R. and Oksche, A. and Rutz, C. and Rosenthal, W. and Schuelein, R.
Molecular Pharmacology 57
(2): 232-242.
February 2000
The role of conserved extracellular cysteine residues in vasopressin V2 receptor function and properties of two naturally occurring mutant receptors with additional extracellular cysteine residues.
Schuelein, R. and Zuehlke, K. and Oksche, A. and Hermosilla, R. and Furkert, J. and Rosenthal, W.
FEBS Letters 466
(1): 101-106.
21 January 2000
The mechanisms of aquaporin control in the renal collecting duct.
Klussmann, E. and Maric, K. and Rosenthal, W.
Reviews of Physiology Biochemistry and Pharmacology 141
: 33-95.
2000
1999
A single negatively charged residue affects the orientation of a membrane protein in the inner membrane of Escherichia coli only when it is located adjacent to a transmembrane domain.
Rutz, C. and Rosenthal, W. and Schuelein, R.
Journal of Biological Chemistry 274
(47): 33757-33763.
19 November 1999
Polarized expression of the vasopressin V2 receptor in Madin-Darby canine kidney cells.
Andersen-Beckh, B. and Dehe, M. and Schuelein, R. and Wiesner, B. and Rutz, C. and Liebenhoff, U. and Rosenthal, W. and Oksche, A.
Kidney International 56
(2): 517-527.
August 1999
Protein kinase A anchoring proteins are required for vasopressin-mediated translocation of aquaporin-2 into cell membranes of renal principal cells.
Klussmann, E. and Maric, K. and Wiesner, B. and Beyermann, M. and Rosenthal, W.
Journal of Biological Chemistry 274
(8): 4934-4938.
19 February 1999
1998
Polarized cell surface expression of the green fluorescent protein-tagged vasopressin V2 receptor in Madin Darby canine kidney cells.
Schuelein, R. and Lorenz, D. and Oksche, A. and Wiesner, B. and Hermosilla, R. and Ebert, J. and Rosenthal, W.
FEBS Letters 441
(2): 170-176.
18 December 1998
Aquaporin-2 expression in primary cultured rat inner medullary collecting duct cells.
Maric, K. and Oksche, A. and Rosenthal, W.
American Journal of Physiology 275
(5 Pt 2): F796-F801.
November 1998
A dileucine sequence and an upstream glutamate residue in the intracellular carboxyl terminus of the vasopressin V2 receptor are essential for cell surface transport in COS.M6 cells.
Schuelein, R. and Hermosilla, R. and Oksche, A. and Dehe, M. and Wiesner, B. and Krause, G. and Rosenthal, W.
Molecular Pharmacology 54
(3): 525-535.
September 1998
A heterotrimeric G protein of the Gi family is required for cAMP-triggered trafficking of aquaporin 2 in kidney epithelial cells.
Valenti, G. and Procino, G. and Liebenhoff, U. and Frigeri, A. and Benedetti, P.A. and Ahnert-Hilger, G. and Nuernberg, B. and Svelto, M. and Rosenthal, W.
Journal of Biological Chemistry 273
(35): 22627-22634.
28 August 1998
The molecular basis of nephrogenic diabetes insipidus.
Oksche, A. and Rosenthal, W.
Journal of Molecular Medicine 76
(5): 326-337.
April 1998
Folding and cell surface expression of the vasopressin V2 receptor: requirement of the intracellular C-terminus.
Oksche, A. and Dehe, M. and Schuelein, R. and Wiesner, B. and Rosenthal, W.
FEBS Letters 424
(1-2): 57-62.
6 March 1998
1997
Congenital nephrogenic diabetes insipidus.
Bichet, D.G. and Oksche, A. and Rosenthal, W.
Journal of the American Society of Nephrology 8
(12): 1951-1958.
December 1997
MUC2 gene suppression in human colorectal carcinomas and their metastases: in vitro evidence of the modulatory role of DNA methylation.
Hanski, C. and Riede, E. and Gratchev, A. and Foss, H.D. and Boehm, C. and Klussmann, E. and Hummel, M. and Mann, B. and Buhr, H.J. and Stein, H. and Kim, Y.S. and Gum, J. and Riecken, E.O.
Laboratory Investigation 77
(6): 685-695.
December 1997
Low O-acetylation of sialyl-Le(x) contributes to its overexpression in colon carcinoma metastases.
Mann, B. and Klussmann, E. and Vandamme-Feldhaus, V. and Iwersen, M. and Hanski, M.L. and Riecken, E.O. and Buhr, H.J. and Schauer, R. and Kim, Y.S. and Hanski, C.
International Journal of Cancer 72
(2): 258-264.
17 July 1997
Topology of eukaryotic multispanning transmembrane proteins: use of LacZ fusions for the localization of cytoplasmic domains in COS.M6 cells.
Schuelein, R. and Rutz, C. and Rosenthal, W.
Protein Engineering 10
(6): 707-713.
June 1997
Koenzym Q10 [Coenzyme Q10].
Rosenthal, W. and Brumhard, M.
Deutsche Medizinische Wochenschrift 122
(9): 278.
28 February 1997
1996
Membrane targeting and determination of transmembrane topology of the human vasopressin V2 receptor.
Schuelein, R. and Rutz, C. and Rosenthal, W.
Journal of Biological Chemistry 271
(46): 28844-28852.
15 November 1996
Two novel mutations in the aquaporin-2 and the vasopressin V2 receptor genes in patients with congenital nephrogenic diabetes insipidus.
Oksche, A. and Moeller, A. and Dickson, J. and Rosendahl, W. and Rascher, W. and Bichet, D.G. and Rosenthal, W.
Human Genetics 98
(5): 587-589.
November 1996
Fucosyltransferase III and sialyl-Le(x) expression correlate in cultured colon carcinoma cells but not in colon carcinoma tissue.
Hanski, C. and Klussmann, E. and Wang, J. and Boehm, C. and Ogorek, D. and Hanski, M.L. and Krueger-Krasagakes, S. and Eberle, J. and Schmitt-Graeff, A. and Riecken, E.O.
Glycoconjugate Journal 13
(5): 727-733.
October 1996
Vasopressin V2 receptor mutants that cause X-linked nephrogenic diabetes insipidus: analysis of expression, processing, and function.
Oksche, A. and Schuelein, R. and Rutz, C. and Liebenhoff, U. and Dickson, J. and Mueller, H. and Birnbaumer, M. and Rosenthal, W.
Molecular Pharmacology 50
(4): 820-828.
October 1996
Properties of the human arginine vasopressin V2 receptor after site-directed mutagenesis of its putative palmitoylation site.
Schuelein, R. and Liebenhoff, U. and Mueller, H. and Birnbaumer, M. and Rosenthal, W.
Biochemical Journal 313
(2): 611-616.
15 January 1996
1995
Identification of Rab3-, Rab5a- and synaptobrevin II-like proteins in a preparation of rat kidney vesicles containing the vasopressin-regulated water channel.
Liebenhoff, U. and Rosenthal, W.
FEBS Letters 365
(2-3): 209-213.
29 May 1995
1994
Two novel mutations in the vasopressin V2 receptor gene in patients with congenital nephrogenic diabetes insipidus.
Oksche, A. and Dickson, J. and Schuelein, R. and Seyberth, H.W. and Mueller, M. and Rascher, W. and Birnbaumer, M. and Rosenthal, W.
Biochemical and Biophysical Research Communications 205
(1): 552-557.
30 November 1994
Expression of MUC2-mucin in colorectal adenomas and carcinomas of different histological types.
Blanke, M. and Klussmann, E. and Krueger-Krasagakes, S. and Schmitt-Graeff, A. and Stolte, M. and Bornhoeft, G. and Stein, H. and Xing, P.X. and McKenzie, I.F. and Verstijnen, C.P. and Riecken, E.O. and Hanski, C.
International Journal of Cancer 59
(3): 301-306.
1 November 1994
Nature and recurrence of AVPR2 mutations in X-linked nephrogenic diabetes insipidus.
Bichet, D.G. and Birnbaumer, M. and Lonergan, M. and Arthus, M.F. and Rosenthal, W. and Goodyer, P. and Nivet, H. and Benoit, S. and Giampietro, P. and Simonetti, S. and Fish, A. and Whitley, C.B. and Jaeger, P. and Gertner, J. and New, M. and DiBona, F.J. and Kaplan, B.S. and Robertson, G.L. and Hendy, G.N. and Fujiwara, T.M. and Morgan, K.
American Journal of Human Genetics 55
(2): 278-286.
August 1994
An extracellular congenital nephrogenic diabetes insipidus mutation of the vasopressin receptor reduces cell surface expression, affinity for ligand, and coupling to the Gs/adenylyl cyclase system.
Birnbaumer, M. and Gilbert, S. and Rosenthal, W.
Molecular Endocrinology 8
(7): 886-894.
July 1994
Mutations in the vasopressin V2 receptor gene in families with nephrogenic diabetes insipidus and functional expression of the Q-2 mutant.
Rosenthal, W. and Seibold, A. and Antaramian, A. and Gilbert, S. and Birnbaumer, M. and Bichet, D.G. and Arthus, M.F. and Lonergan, M.
Cellular and Molecular Biology 40
(3): 429-436.
May 1994
Stimulation of rat parietal cell function by histamine and GLP-1-(7-36) amide is mediated by Gs alpha.
Schmidtler, J. and Dehne, K. and Offermanns, S. and Rosenthal, W. and Classen, M. and Schepp, W.
American Journal of Physiology 266
(5 Pt 1): G775-G782.
May 1994
1993
Altered glycosylation of the MUC-1 protein core contributes to the colon carcinoma-associated increase of mucin-bound sialyl-Lewis(x) expression.
Hanski, C. and Drechsler, K. and Hanisch, F.G. and Sheehan, J. and Manske, M. and Ogorek, D. and Klussmann, E. and Hanski, M.L. and Blank, M. and Xing, P.X. and McKenzie, I.F.C. and Devine, P.L. and Riecken, E.O.
Cancer Research 53
(17): 4082-4088.
1 September 1993
X-linked nephrogenic diabetes insipidus mutations in North America and the Hopewell hypothesis.
Bichet, D.G. and Arthus, M.F. and Lonergan, M. and Hendy, G.N. and Paradis, A.J. and Fujiwara, T.M. and Morgan, K. and Gregory, M.C. and Rosenthal, W. and Didwania, A.
Journal of Clinical Investigation 92
(3): 1262-1268.
September 1993
Cloning of the human type-2 vasopressin receptor gene.
Seibold, A. and Rosenthal, W. and Barberis, C. and Birnbaumer, M.
Annals of the New York Academy of Sciences 689
: 570-572.
22 July 1993
Nephrogenic diabetes insipidus. A V2 vasopressin receptor unable to stimulate adenylyl cyclase.
Rosenthal, W. and Antaramian, A. and Gilbert, S. and Birnbaumer, M.
Journal of Biological Chemistry 268
(18): 13030-13033.
25 June 1993
Expression cloning of the human V2 vasopressin receptor.
Barberis, C. and Seibold, A. and Ishido, M. and Rosenthal, W. and Birnbaumer, M.
Regulatory Peptides 45
(1-2): 61-66.
29 April 1993
The vasopressin type 2 receptor gene. Chromosomal localization and its role in nephrogenic diabetes insipidus.
Seibold, A. and Rosenthal, W. and Bichet, D.G. and Birnbaumer, M.
Regulatory Peptides 45
(1-2): 67-71.
29 April 1993
1992
Structure and chromosomal localization of the human antidiuretic hormone receptor gene.
Seibold, A. and Brabet, P. and Rosenthal, W. and Birnbaumer, M.
American Journal of Human Genetics 51
(5): 1078-1083.
November 1992
Molecular identification of the gene responsible for congenital nephrogenic diabetes insipidus.
Rosenthal, W. and Seibold, A. and Antaramian, A. and Lonergan, M. and Arthus, M.F. and Hendy, G.N. and Birnbaumer, M. and Bichet, D.G.
Nature 359
(6392): 233-235.
17 September 1992
Heterogeneity of three electrophoretically distinct Go alpha-subunits in mammalian brain.
Spicher, K. and Nuernberg, B. and Jaeger, B. and Rosenthal, W. and Schultz, G.
FEBS Letters 307
(2): 215-218.
28 July 1992
Molecular cloning of the receptor for human antidiuretic hormone.
Birnbaumer, M. and Seibold, A. and Gilbert, S. and Ishido, M. and Barberis, C. and Antaramian, A. and Brabet, P. and Rosenthal, W.
Nature 357
(6376): 333-335.
28 May 1992
Pertussis toxin reverses prostaglandin E2- and somatostatin-induced inhibition of rat parietal cell H(+)-production.
Schmidtler, J. and Rosenthal, W. and Offermanns, S. and Schusdziarra, V. and Classen, M. and Schepp, W.
Cellular Signalling 4
(3): 321-329.
May 1992
Characterization of GTP-binding proteins in Golgi-associated membrane vesicles from rat adipocytes.
Schuermann, A. and Rosenthal, W. and Schultz, G. and Joost, H.G.
Biochemical Journal 283
(Pt 3): 795-801.
1992
Exocytosis from permeabilized bovine adrenal chromaffin cells is differently modulated by guanosine 5'-[gamma-thio]triphosphate and guanosine 5'-[beta gamma-imido]triphosphate. Evidence for the involvement of various guanine nucleotide-binding proteins.
Ahnert-Hilger, G. and Wegenhorst, U. and Stecher, B. and Spicher, K. and Rosenthal, W. and Gratz, M.
Biochemical Journal 284
(Pt 2): 321-326.
1992
1991
Morphological, biochemical, and electrophysiological characterization of a clonal cell (H9c2) line from rat heart.
Hescheler, J. and Meyer, R. and Plant, S. and Krautwurst, D. and Rosenthal, W. and Schultz, G.
Circulation Research 69
(6): 1476-1486.
December 1991
Identification of proteins resembling G-protein alpha subunits in locust muscle.
Soeling, A. and Walther, C. and Rosenthal, W.
Biochemical and Biophysical Research Communications 180
(2): 1075-1082.
31 October 1991
Involvement of pertussis toxin-sensitive G-proteins in the hormonal inhibition of dihydropyridine-sensitive Ca2+ currents in an insulin-secreting cell line (RINm5F).
Schmidt, A. and Hescheler, J. and Offermanns, S. and Spicher, K. and Hinsch, K.D. and Klinz, F.J. and Codina, J. and Birnbaumer, L. and Gausepohl, H. and Frank, R. and Schultz, G. and Rosenthal, W.
Journal of Biological Chemistry 266
(27): 18025-18033.
25 September 1991
Assignment of G-protein subtypes to specific receptors inducing inhibition of calcium currents.
Kleuss, C. and Hescheler, J. and Ewel, C. and Rosenthal, W. and Schultz, G. and Wittig, B.
Nature 353
(6339): 43-48.
5 September 1991
Inhibition of voltage-dependent Ca2+ currents and activation of pertussis toxin-sensitive G-proteins via muscarinic receptors in GH3 cells.
Offermanns, S. and Gollasch, M. and Hescheler, J. and Spicher, K. and Schmidt, A. and Schultz, G. and Rosenthal, W.
Molecular Endocrinology 5
(7): 995-1002.
July 1991
Inhibition of Ca2+ channels via alpha 2-adrenergic and muscarinic receptors in pheochromocytoma (PC-12) cells.
Gollasch, M. and Hescheler, J. and Spicher, K. and Klinz, F.J. and Schultz, G. and Rosenthal, W.
American Journal of Physiology 260
(6 Pt 1): C1282-C1289.
June 1991
Identification of the G-protein alpha-subunit encoded by alpha o2 cDNA as a 39 kDa pertussis toxin substrate.
Spicher, K. and Klinz, F.J. and Rudolph, U. and Codina, J. and Birnbaumer, L. and Schultz, G. and Rosenthal, W.
Biochemical and Biophysical Research Communications 175
(2): 473-479.
15 March 1991
Evidence for opioid receptor-mediated activation of the G-proteins, Go and Gi2, in membranes of neuroblastoma x glioma (NG108-15) hybrid cells.
Offermanns, S. and Schultz, G. and Rosenthal, W.
Journal of Biological Chemistry 266
(6): 3365-3368.
25 February 1991
G protein function in the ischaemic myocardium.
Will-Shahab, L. and Rosenthal, W. and Schulze, W. and Kuettner, I.
European Heart Journal 12
(Suppl F): 135-138.
1 January 1991
Immunocytochemical localization of G-proteins (alpha subunits) in rat heart tissue.
Schulze, W. and Koessler, A. and Hinsch, K.D. and Rosenthal, W. and Will-Shahab, L. and Kuettner, I. and Rada, T. and Vannauer, M. and Breter, H.
European Heart Journal 12
(Suppl F): 132-134.
1 January 1991
Identification of receptor-activated G proteins with photoreactive GTP analog, [alpha-32P]GTP azidoanilide.
Offermanns, S. and Schultz, G. and Rosenthal, W.
Methods in Enzymology 195
: 286-301.
1991
Improved purification and characterization of membraneous and cytosolic inositol phospholipid-specific phospholipases C from porcine brain cortex.
Hoffmann, B. and Seib, C. and Hoeer, A. and Hoeer, D. and Oberdisse, E. and Rosenthal, W. and Schultz, G.
Biomedica Biochimica Acta 50
(1): 31-46.
1991
1990
A high-affinity bradykinin receptor in membranes from rat myometrium is coupled to pertussis toxin-sensitive G-proteins of the Gi family.
Liebmann, C. and Offermanns, S. and Spicher, K. and Hinsch, K.D. and Schnittler, M. and Morgat, J.L. and Reissmann, S. and Schultz, G. and Rosenthal, W.
Biochemical and Biophysical Research Communications 167
(3): 910-917.
30 March 1990
Agonist-sensitive binding of a photoreactive GTP analog to a G-protein alpha-subunit in membranes of HL-60 cells.
Offermans, S. and Schaefer, R. and Hoffmann, B. and Bombien, E. and Spicher, K. and Hinsch, K.D. and Schultz, G. and Rosenthal, W.
FEBS Letters 260
(1): 14-18.
15 January 1990
Pertussis toxin-sensitive G-proteins: participation in the modulation of voltage-dependent Ca2+ channels by hormones and neurotransmitters.
Rosenthal, W. and Hescheler, J. and Eckert, R. and Offermanns, S. and Schmidt, A. and Hinsch, K.D. and Spicher, K. and Trautwein, W. and Schultz, G.
Advances in Second Messenger and Phosphoprotein Research 24
: 89-94.
1990
Role of G proteins in calcium channel modulation.
Schultz, G. and Rosenthal, W. and Hescheler, J. and Trautwein, W.
Annual Review of Physiology 52
: 275-292.
1990
1989
Phosphorylation of G-protein alpha-subunits in intact adipose cells: evidence against a mediating role in insulin-dependent metabolic effects.
Joost, H.G. and Schmitz-Salue, C. and Hinsch, K.D. and Schultz, G. and Rosenthal, W.
European Journal of Pharmacology 172
(6): 461-469.
5 December 1989
Differential sensitivity to guanine nucleotides of basal and insulin-stimulated glucose transporter activity reconstituted from adipocyte membrane fractions.
Schuermann, A. and Rosenthal, W. and Hinsch, K.D. and Joost, H.G.
FEBS Letters 255
(2): 259-264.
25 September 1989
Tissue distribution of beta 1- and beta 2-subunits of regulatory guanine nucleotide-binding proteins.
Hinsch, K.D. and Tychowiecka, I. and Gausepohl, H. and Frank, R. and Rosenthal, W. and Schultz, G.
Biochimica et Biophysica Acta 1013
(1): 60-67.
4 September 1989
The cytosolic G-protein alpha-subunit in human neutrophils responds to treatment with guanine nucleotides and magnesium.
Rudolph, U. and Schultz, G. and Rosenthal, W.
FEBS Letters 251
(1-2): 137-142.
17 July 1989
G-protein alpha-subunits in cytosolic and membranous fractions of human neutrophils.
Rudolph, U. and Koesling, D. and Hinsch, K.D. and Seifert, R. and Bigalke, M. and Schultz, G. and Rosenthal, W.
Molecular and Cellular Endocrinology 63
(1-2): 143-153.
May 1989
Secretion-stimulating and secretion-inhibiting hormones stimulate high-affinity pertussis-toxin-sensitive GTPases in membranes of a pituitary cell line.
Offermanns, S. and Schultz, G. and Rosenthal, W.
European Journal of Biochemistry 180
(2): 283-287.
15 March 1989
Bidirektionale hormonale Modulation spannungsabhängiger Ca2+-Kanle [Bidirectional hormonal modulation of voltage dependent ca2+ channels].
Rosenthal, W. and Hescheler, J. and Hinsch, K.D. and Schultz, G.
Arzneimittelforschung 39
(1A): 143-148.
January 1989
1988
Immunochemical detection of the alpha-subunit of the G-protein, GZ, in membranes and cytosols of mammalian cells.
Spicher, K. and Hinsch, K.D. and Gausepohl, H. and Frank, R. and Rosenthal, W. and Schultz, G.
Biochemical and Biophysical Research Communications 157
(3): 883-890.
30 December 1988
Different types of ADP-ribose protein bonds formed by botulinum C2 toxin, botulinum ADP-ribosyltransferase C3 and pertussis toxin.
Aktories, K. and Just, I. and Rosenthal, W.
Biochemical and Biophysical Research Communications 156
(1): 361-367.
14 October 1988
Adipocyte plasma membranes contain two Gi subtypes but are devoid of Go.
Hinsch, K.D. and Rosenthal, W. and Spicher, K. and Binder, T. and Gausepohl, H. and Frank, R. and Schultz, G. and Joost, H.G.
FEBS Letters 238
(1): 191-196.
26 September 1988
Control of voltage-dependent Ca2+ channels by G protein-coupled receptors.
Rosenthal, W. and Hescheler, J. and Trautwein, W. and Schultz, G.
FASEB Journal 2
(12): 2784-2790.
September 1988
Degradation of inositol 1,3,4,5-tetrakisphosphates by porcine brain cytosol yields inositol 1,3,4-trisphosphate and inositol 1,4,5-trisphosphate.
Hoeer, D. and Kwiatkowski, A. and Seib, C. and Rosenthal, W. and Schultz, G. and Oberdisse, E.
Biochemical and Biophysical Research Communications 154
(2): 668-675.
29 July 1988
Activation of protein kinase C by cis- and trans-fatty acids and its potentiation by diacylglycerol.
Seifert, R. and Schaechtele, C. and Rosenthal, W. and Schultz, G.
Biochemical and Biophysical Research Communications 154
(1): 20-26.
15 July 1988
The role of nucleoside-diphosphate kinase reactions in G protein activation of NADPH oxidase by guanine and adenine nucleotides.
Seifert, R. and Rosenthal, W. and Schultz, G. and Wieland, T. and Gierschick, P. and Jakobs, K.H.
European Journal of Biochemistry 175
(1): 51-55.
15 July 1988
Guaninnucleotid-bindende Proteine als membranaere Signaltransduktionskomponenten und Regulatoren enzymatischer Effektoren [G-proteins and the regulation of intracellular signal-generating enzymes].
Rosenthal, W. and Schultz, G.
Klinische Wochenschrift 66
(12): 511-523.
15 June 1988
Cyclic AMP-independent, dual regulation of voltage-dependent Ca2+ currents by LHRH and somatostatin in a pituitary cell line.
Rosenthal, W. and Hescheler, J. and Hinsch, K.D. and Spicher, K. and Trautwein, W. and Schultz, G.
EMBO Journal 7
(6): 1627-1633.
June 1988
A radiometric method for the determination of NADH in subpicomole amounts.
Weber, G. and Rosenthal, W. and Oberdisse, E.
Journal of Biochemical and Biophysical Methods 15
(6): 295-306.
April 1988
Angiotensin II-induced stimulation of voltage-dependent Ca2+ currents in an adrenal cortical cell line.
Hescheler, J. and Rosenthal, W. and Hinsch, K.D. and Wulfern, M. and Trautwein, W. and Schultz, G.
EMBO Journal 7
(3): 619-624.
March 1988
Funktionen Guaninnucleotid-bindender Proteine bei der rezeptorvermittelten Modulation spannungsabhngiger Ionenkanaele [G-proteins and the modulation of voltage-dependent ion channels].
Rosenthal, W. and Schultz, G.
Klinische Wochenschrift 66
(13): 557-564.
1988
Involvement of the guanine nucleotide-binding protein, No, in the inhibitory regulation of neuronal calcium channels.
Hescheler, J. and Rosenthal, W. and Wulfern, M. and Tang, M. and Yajima, M. and Trautwein, W. and Schultz, G.
Advances in Second Messenger and Phosphoprotein Research 21
: 165-174.
1988
Receptor- and G-protein-mediated modulations of voltage-dependent calcium channels.
Rosenthal, W. and Hescheler, J. and Trautwein, W. and Schultz, G.
Cold Spring Harbor Symposia on Quantitative Biology 53
(Pt 1): 247-254.
1988
1987
Resolution of transducin subunits by chromatography on blue sepharose.
Kleuss, C. and Pallast, M. and Brendel, S. and Rosenthal, W. and Schultz, G.
Journal of chromatography 407
: 281-289.
16 October 1987
Modulations of voltage-dependent ion channels by extracellular signals.
Rosenthal, W. and Schultz, G.
Trends in Pharmacological Sciences 8
(9): 351-354.
September 1987
In vitro synthesis of 32P-labelled phosphatidylinositol 4,5-bisphosphate and its hydrolysis by smooth muscle membrane-bound phospholipase C.
Fuelle, H.J. and Hoeer, D. and Lache, W. and Rosenthal, W. and Schultz, G. and Oberdisse, E.
Biochemical and Biophysical Research Communications 145
(2): 673-679.
15 June 1987
The GTP-binding protein, Go, regulates neuronal calcium channels.
Hescheler, J. and Rosenthal, W. and Trautwein, W. and Schultz, G.
Nature 325
(6103): 445-447.
29 January 1987
NADP efficiently inhibits endogenous but not pertussis toxin-catalyzed covalent modification of membrane proteins incubated with NAD.
Rosenthal, W. and Binder, T. and Schultz, G.
FEBS Letters 211
(2): 137-143.
26 January 1987
1986
Identification and characterization of the 35-kDa beta subunit of guanine-nucleotide-binding proteins by an antiserum raised against transducin.
Rosenthal, W. and Koesling, D. and Rudolph, U. and Kleuss, C. and Pallast, M. and Yajima, M. and Schultz, G.
European Journal of Biochemistry 158
(2): 255-263.
15 July 1986
Guanine nucleotides stimulate NADPH oxidase in membranes of human neutrophils.
Seifert, R. and Rosenthal, W. and Schultz, G.
FEBS Letters 205
(1): 161-165.
1986
1985
Characterization by two-dimensional peptide mapping of the gamma subunits of Ns and Ni, the regulatory proteins of adenylyl cyclase, and of transducin, the guanine nucleotide-binding protein of rod outer segments of the eye.
Hildebrandt, J.D. and Codina, J. and Rosenthal, W. and Birnbaumer, L. and Neer, E.J. and Yamazaki, A. and Bitensky, M.W.
Journal of Biological Chemistry 260
(27): 14867-14872.
25 November 1985
Prinzipien der transmembranaeren Signalumsetzung bei der Wirkung von Hormonen und Neurotransmittern [Principles of transmembranous signal transduction in the action of hormones and neurotransmitters].
Schultz, G. and Rosenthal, W.
Arzneimittelforschung 35
(12A): 1879-1885.
1985
Properties of human erythrocyte Ns and Ni, the regulatory components of adenylate cyclase, as purified without regulatory ligands.
Hildebrandt, J.D. and Codina, J. and Rosenthal, W. and Sunyer, T. and Iyengar, R. and Birnbaumer, L.
Advances in Cyclic Nucleotide and Protein Phosphorylation Research 19
: 87-101.
1985
Purification of Ns and Ni, the coupling proteins of hormone-sensitive adenylyl cyclases without intervention of activating regulatory ligands.
Codina, J. and Rosenthal, W. and Hildebrandt, J.D. and Birnbaumer, L. and Sekura, R.D.
Methods in Enzymology 109
: 446-465.
1985
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