Browse by Research Team

2016

Pharmacological interference with protein-protein interactions of A-kinase anchoring proteins as a strategy for the treatment of disease.
Deák, V.A. and Klussmann, E.
Current Drug Targets 17 (10): 1147-1171. 1 August 2016

2015

Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domains.
Bolger, G.B., Dunlop, A.J., Meng, D., Day, J.P., Klussmann, E., Baillie, G.S., Adams, D.R. and Houslay, M.D.
Cellular Signalling 27 (4): 756-769. April 2015

Regulation of sarcoplasmic reticulum Ca(2+) ATPase 2 (SERCA2) activity by phosphodiesterase 3A (PDE3A) in human myocardium: phosphorylation-dependent interaction of PDE3A1 with SERCA2.
Ahmad, F., Shen, W., Vandeput, F., Szabo-Fresnais, N., Krall, J., Degerman, E., Goetz, F., Klussmann, E., Movsesian, M. and Manganiello, V.
Journal of Biological Chemistry 290 (11): 6763-6776. 13 March 2015

Screening for small molecule disruptors of AKAP-PKA interactions.
Schächterle, C., Christian, F., Fernandes, J.M.P. and Klussmann, E.
Methods in Molecular Biology 1294 : 151-166. 2 March 2015

Keeping those telomeres short! an innovative intratumoral long-term drug delivery system.
Laster, B.H., Isaacson, C., Perets, E., Msamra, M., Priel, E., Kalef-Ezra, J. and Kost, J.
Journal of Cancer Research and Clinical Oncology 141 (1): 23-34. January 2015

2014

The crystal structure of the RhoA-AKAP-Lbc DH-PH domain complex.
Abdul Azeez, K.R., Knapp, S., Fernandes, J.M.P., Klussmann, E. and Elkins, J.M.
Biochemical Journal 464 (2): 231-239. 1 December 2014

Flexible, polymer-supported synthesis of sphingosine derivatives provides ceramides with enhanced biological activity.
El-Dahshan, A., Al-Gharabli, S.I., Radetzki, S., Al-Tel, T.H., Kumar, P. and Rademann, J.
Bioorganic and Medicinal Chemistry 22 (19): 5506-5512. 1 October 2014

G protein-coupled estrogen receptor 1 (GPER) mediates relaxation of coronary arteries via cAMP/PKA-dependent activation of MLCP.
Yu, X., Li, F., Klussmann, E., Stallone, J.N. and Han, G.
American Journal of Physiology Endocrinology and Metabolism 307 (4): E398-E407. 15 August 2014

2013

Highly functionalized terpyridines as competitive inhibitors of AKAP-PKA interactions.
Schäfer, G., Milić, J, Eldahshan, A, Götz, F., Zühlke, K., Schillinger, C., Kreuchwig, A., Elkins, J.M., Abdul Azeez, K.R.A., Oder, A., Moutty, M.C., Masada, N., Beerbaum, M., Schlegel, B., Niquet, S., Schmieder, P., Krause, G., von Kries, J.P., Cooper, D.M.F., Knapp, S., Rademann, J., Rosenthal, W. and Klussmann, E.
Angewandte Chemie International Edition 52 (46): 12187-12191. 11 November 2013

AKAPS act in a two-step mechanism of memory acquisition.
Scheunemann, L., Skroblin, P., Hundsrucker, C., Klussmann, E., Efetova, M. and Schwärzel, M.
Journal of Neuroscience 33 (44): 17422-17428. 30 October 2013

Culturing primary rat inner medullary collecting duct cells.
Faust, D., Geelhaar, A., Eisermann, B., Eichhorst, J., Wiesner, B., Rosenthal, W. and Klussmann, E.
Journal of Visualized Experiments (76): e50366. 21 June 2013

Small-molecule screening identifies modulators of aquaporin-2 trafficking.
Bogum, J., Faust, D., Zühlke, K., Eichhorst, J., Moutty, M.C., Furkert, J., Eldahshan, A., Neuenschwander, M., von Kries, J.P., Wiesner, B., Trimpert, C., Deen, P.M., Valenti, G., Rosenthal, W. and Klussmann, E.
Journal of the American Society of Nephrology 24 (5): 744-758. April 2013

2012

Mechanism for targeting the A-kinase anchoring protein AKAP18δ to the membrane.
Horner, A., Goetz, F., Tampe, R., Klussmann, E. and Pohl, P.
Journal of Biological Chemistry 287 (51): 42495-42501. 14 December 2012

A key phosphorylation site in AC8 mediates regulation of Ca2+-dependent cAMP dynamics by an AC8-AKAP79-PKA signalling complex.
Willoughby, D., Halls, M.L., Everett, K.L., Skroblin, P., Klussmann, E. and Cooper, D.M.F.
Journal of Cell Science 125 (Pt 23): 5850-5859. 1 December 2012

Vasopressin increases S261 phosphorylation in AQP2-P262L, a mutant in recessive nephrogenic diabetes insipidus.
Trimpert, C., van den Berg, D.T.M., Fenton, R.A., Klussmann, E. and Deen, P.M.T.
Nephrology Dialysis Transplantation 27 (12): 4389-4397. December 2012

The protease-activated receptor 1 possesses a functional and cleavable signal peptide which is necessary for receptor expression.
Zampatis, D.E., Rutz, C., Furkert, J., Schmidt, A., Wuestenhagen, D., Kubick, S., Tsopanoglou, N.E. and Schuelein, R.
FEBS Letters 586 (16): 2351-2359. 31 May 2012

A-kinase anchoring proteins as potential drug targets.
Troeger, J., Moutty, M.C., Skroblin, P. and Klussmann, E.
British Journal of Pharmacology 166 (2): 420-433. May 2012

Direct binding between Orai1 and AC8 mediates dynamic interplay between Ca2+ and cAMP signaling.
Willoughby, D., Everett, K.L., Halls, M.L., Pacheco, J., Skroblin, P., Vaca, L., Klussmann, E. and Cooper, D.M.
Science Signaling 5 (219): ra29. 10 April 2012

Functional significance of cleavable signal peptides of G protein-coupled receptors.
Schuelein, R., Westendorf, C., Krause, G. and Rosenthal, W.
European Journal of Cell Biology 91 (4): 294-299. April 2012

2011

Spinophilin regulates central angiotensin II-mediated effect on blood pressure.
da Costa Goncalves, A.C., Fontes, M.A., Klussmann, E., Qadri, F., Janke, J., Gollasch, M., Schleifenbaum, J., Mueller, D., Jordan, J., Tank, J., Luft, F.C. and Gross, V.
Journal of Molecular Medicine 89 (12): 1219-1229. December 2011

Inhibition of the biosynthesis of the human endothelin B receptor by the cyclodepsipeptide cotransin.
Westendorf, C., Schmidt, A., Coin, I., Furkert, J., Ridelis, I., Zampatis, D., Rutz, C., Wiesner, B., Rosenthal, W., Beyermann, M. and Schuelein, R.
Journal of Biological Chemistry 286 (41): 35588-35600. 14 October 2011

Interaction between LIS1 and PDE4, and its role in cytoplasmic dynein function.
Murdoch, H., Vadrevu, S., Prinz, A., Dunlop, A.J., Klussmann, E., Bolger, G.B., Norman, J.C. and Houslay, M.D.
Journal of Cell Science 124 (Pt 13): 2253-2266. 1 July 2011

Elucidation of a structural basis for the inhibitor-driven, p62 (SQSTM1)-dependent intracellular redistribution of cAMP phosphodiesterase-4A4 (PDE4A4).
Day, J.P., Lindsay, B., Riddell, T., Jiang, Z., Allcock, R.W., Abraham, A., Sookup, S., Christian, F., Bogum, J., Martin, E.K., Rae, R.L., Anthony, D., Rosair, G.M., Houslay, D.M., Huston, E., Baillie, G.S., Klussmann, E., Houslay, M.D. and Adams, D.R.
Journal of Medicinal Chemistry 54 (9): 3331-3347. 12 May 2011

Small molecule AKAP/PKA interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes.
Christian, F., Szaszak, M., Friedl, S., Drewianka, S., Lorenz, D., Goncalves, A., Furkert, J., Vargas, C., Schmieder, P., Goetz, F., Zuehlke, K., Moutty, M., Goettert, H., Joshi, M., Reif, B., Haase, H., Morano, I., Grossmann, S., Klukovits, A., Verli, J., Gaspar, R., Noack, C., Bergmann, M., Kass, R., Hampel, K., Kashin, D., Genieser, H.G., Herberg, F.W., Willoughby, D., Cooper, D.M., Baillie, G.S., Houslay, M.D., von Kries, J.P., Zimmermann, B., Rosenthal, W. and Klussmann, E.
Journal of Biological Chemistry 286 (11): 9079-9096. 18 March 2011

2010

Routes of epithelial water flow: aquaporins versus cotransporters.
Mollajew, R., Zocher, F., Horner, A., Wiesner, B., Klussmann, E. and Pohl, P.
Biophysical Journal 99 (11): 3647-3656. 1 December 2010

The pseudo signal peptide of the corticotropin-releasing factor receptor type 2a decreases receptor expression and prevents Gi-mediated inhibition of adenylyl cyclase activity.
Schulz, K., Rutz, C., Westendorf, C., Ridelis, I., Vogelbein, S., Furkert, J., Schmidt, A., Wiesner, B. and Schuelein, R.
Journal of Biological Chemistry 285 (43): 32878-32887. 22 October 2010

Reciprocal regulation of aquaporin-2 abundance and degradation by protein kinase A and p38-MAP kinase.
Nedvetsky, P.I., Tabor, V., Tamma, G., Beulshausen, S., Skroblin, P., Kirschner, A., Mutig, K., Boltzen, M., Petrucci, O., Vossenkaemper, A., Wiesner, B., Bachmann, S., Rosenthal, W. and Klussmann, E.
Journal of the American Society of Nephrology 21 (10): 1645-1656. October 2010

Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK.
Li, X., Vadrevu, S., Dunlop, A., Day, J., Advant, N., Troeger, J., Klussmann, E., Jaffrey, E., Hay, R.T., Adams, D.R., Houslay, M.D. and Baillie, G.S.
Biochemical Journal 428 (1): 55-65. 15 May 2010

Glycogen synthase kinase 3β interaction protein functions as an A-kinase anchoring protein.
Hundsrucker, C., Skroblin, P., Christian, F., Zenn, M., Popara, V., Joshi, M., Eichhorst, J., Wiesner, B., Herberg, F.W., Reif, B., Rosenthal, W. and Klussmann, E.
Journal of Biological Chemistry 285 (8): 5507-5521. 19 February 2010

Mechanisms of protein kinase A anchoring.
Skroblin, P., Grossmann, S., Schaefer, G., Rosenthal, W. and Klussmann, E.
International Review of Cell and Molecular Biology 283 (C): 235-330. 2010

2009

Structural determinants for selective recognition of peptide ligands for endothelin receptor subtypes ETA and ETB.
Laettig, J., Oksche, A., Beyermann, M., Rosenthal, W. and Krause, G.
Journal of Peptide Science 15 (7): 479-491. July 2009

MEK1 binds directly to βarrestin1, influencing both its phosphorylation by ERK and the timing of its isoprenaline-stimulated internalization.
Meng, D., Lynch, M.J., Huston, E., Beyermann, M., Eichhorst, J., Adams, D.R., Klussmann, E., Houslay, M.D. and Baillie, G.S.
Journal of Biological Chemistry 284 (17): 11425-1135. 24 April 2009

The sequence after the signal peptide of the g protein-coupled endothelin B receptor is required for efficient translocon gating at the endoplasmic reticulum membrane.
Alken, M., Schmidt, A., Rutz, C., Furkert, J., Kleinau, G., Rosenthal, W. and Schuelein, R.
Molecular Pharmacology 75 (4): 801-811. April 2009

Regulation of aquaporin-2 trafficking.
Nedvetsky, P.I., Tamma, G., Beulshausen, S., Valenti, G., Rosenthal, W. and Klussmann, E.
Handbook of Experimental Pharmacology 190 (II): 133-157. 2009

2008

Compartmentalized cAMP signalling in regulated exocytic processes in non-neuronal cells.
Szaszak, M., Christian, F., Rosenthal, W. and Klussmann, E.
Cellular Signalling 20 (4): 590-601. April 2008

Derlin-1 and p97/valosin-containing protein mediate the endoplasmic reticulum-associated degradation of human V2 vasopressin receptors.
Schwieger, I., Lautz, K., Krause, E., Rosenthal, W., Wiesner, B. and Hermosilla, R.
Molecular Pharmacology 73 (3): 697-708. March 2008

Direct AKAP-mediated protein-protein interactions as potential drug targets.
Hundsrucker, C. and Klussmann, E.
Handbook of Experimental Pharmacology 186 : 483-503. 2008

2007

1H NMR structural and functional characterisation of a cAMP-specific phosphodiesterase-4D5 (PDE4D5) N-terminal region peptide that disrupts PDE4D5 interaction with the signalling scaffold proteins, beta-arrestin and RACK1.
Smith, K.J., Baillie, G.S., Hyde, E.I., Li, X., Houslay, T.M., McCahill, A., Dunlop, A.J., Bolger, G.B., Klussmann, E., Adams, D.R. and Houslay, M.D.
Cellular Signalling 19 (12): 2612-2624. December 2007

AKAP complex regulates Ca2+ re-uptake into heart sarcoplasmic reticulum.
Lygren, B., Carlson, C.R., Santamaria, K., Lissandron, V., McSorley, T., Litzenberg, J., Lorenz, D., Wiesner, B., Rosenthal, W., Zaccolo, M., Tasken, K. and Klussmann, E.
EMBO Reports 8 (11): 1061-1067. 1 November 2007

Microtubules are needed for the perinuclear positioning of aquaporin-2 after its endocytic retrieval in renal principal cells.
Vossenkaemper, A., Nedvetsky, P.I., Wiesner, B., Furkert, J., Rosenthal, W. and Klussmann, E.
American Journal of Physiology Cell Physiology 293 (3): C1129-C1138. 11 September 2007

Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes to dissociation by elevated intracellular cAMP levels.
Murdoch, H., Mackie, S., Collins, D.M., Hill, E.V., Bolger, G.B., Klussmann, E., Porteous, D.J., Millar, J.K. and Houslay, M.D.
Journal of Neuroscience 27 (35): 9513-9524. 29 August 2007

Rescue of a nephrogenic diabetes insipidus-causing vasopressin V2 receptor mutant by cell-penetrating peptides.
Oueslati, M., Hermosilla, R., Schoenenberger, E., Oorschot, V., Beyermann, M., Wiesner, B., Schmidt, A., Klumperman, J., Rosenthal, W. and Schuelein, R.
Journal of Biological Chemistry 282 (28): 20676-20685. 13 July 2007

p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway.
Sachs, B.D., Baillie, G.S., McCall, J.R., Passino, M.A., Schachtrup, C., Wallace, D.A., Dunlop, A.J., MacKenzie, K.F., Klussmann, E., Lynch, M.J., Sikorski, S.L., Nuriel, T., Tsigelny, I., Zhang, J., Houslay, M.D., Chao, M.V. and Akassoglou, K.
Journal of Cell Biology 177 (6): 1119-1132. 18 June 2007

Mapping binding sites for the PDE4D5 cAMP-specific phosphodiesterase to the N- and C-domains of beta-arrestin using spot-immobilized peptide arrays.
Baillie, G.S., Adams, D.R., Bhari, N., Houslay, T.M., Vadrevu, S., Meng, D., Li, X., Dunlop, A., Milligan, G., Bolger, G.B., Klussmann, E. and Houslay, M.D.
Biochemical Journal 404 (1): 71-80. 15 May 2007

A role of myosin Vb and Rab11-FIP2 in the aquaporin-2 shuttle.
Nedvetsky, P.I., Stefan, E., Frische, S., Santamaria, K., Wiesner, B., Valenti, G., Hammer, J.A., Nielsen, S., Goldenring, J.R., Rosenthal, W. and Klussmann, E.
Traffic 8 (2): 110-123. February 2007

Compartmentalization of cAMP-dependent signaling by phosphodiesterase-4D is involved in the regulation of vasopressin-mediated water reabsorption in renal principal cells.
Stefan, E., Wiesner, B., Baillie, G.S., Mollajew, R., Henn, V., Lorenz, D., Furkert, J., Santamaria, K., Nedvetsky, P.I., Hundsrucker, C., Beyermann, M., Krause, E., Pohl, P., Gall, I., MacIntyre, A.N., Bachmann, S., Houslay, M.D., Rosenthal, W. and Klussmann, E.
Journal of the American Society of Nephrology 18 (1): 199-212. January 2007

Protein-Protein-Interaktionen als Ziel fuer neue Pharmaka : EU-Projekt thera-cAMP.
Klussmann, E.
BIOforum 2 : 32-34. 2007

Protein-protein interactions as target for new therapeutic molecules.
Klussmann, E.
BIOforum Europe 3 : 18-19. 2007

2006

The corticotropin-releasing factor receptor type 2a contains an N-terminal pseudo signal peptide.
Rutz, C., Renner, A., Alken, M., Schulz, K., Beyermann, M., Wiesner, B., Rosenthal, W. and Schuelein, R.
Journal of Biological Chemistry 281 (34): 24910-24921. 25 August 2006

Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, beta-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5.
Bolger, G.B., Baillie, G.S., Li, X., Lynch, M.J., Herzyk, P., Mohamed, A., Mitchell, L.H., McCahill, A., Hundsrucker, C., Klussmann, E., Adams, D.R. and Houslay, M.D.
Biochemical Journal 398 (1): 23-36. 15 August 2006

Peptides for disruption of PKA anchoring.
Hundsrucker, C., Rosenthal, W. and Klussmann, E.
Biochemical Society Transactions 34 (Pt 4): 472-473. 1 August 2006

First international meeting on anchored cAMP signaling pathways, Biomedical Campus, Berlin-Buch, Germany, 15-16 October 2005.
Klussmann, E.
European Journal of Cell Biology 85 (7): 581-584. 5 July 2006

Spatial organisation of AKAP18 and PDE4 isoforms in renal collecting duct principal cells.
McSorley, T., Stefan, E., Henn, V., Wiesner, B., Baillie, G.S., Houslay, M.D., Rosenthal, W. and Klussmann, E.
European Journal of Cell Biology 85 (7): 673-678. 5 July 2006

High-affinity AKAP7delta-protein kinase A interaction yields novel protein kinase A-anchoring disruptor peptides.
Hundsrucker, C., Krause, G., Beyermann, M., Prinz, A., Zimmermann, B., Diekmann, O., Lorenz, D., Stefan, E., Nedvetsky, P., Dathe, M., Christian, F., McSorley, T., Krause, E., McConnachie, G., Herberg, F.W., Scott, J.D., Rosenthal, W. and Klussmann, E.
Biochemical Journal 396 (2): 297-306. 1 June 2006

Endothelin A and endothelin B receptors differ in their ability to stimulate ERK1/2 activation.
Grantcharova, E., Reusch, H.P., Beyermann, M., Rosenthal, W. and Oksche, A.
Experimental Biology and Medicine 231 (6): 757-760. June 2006

N-terminal proteolysis of the endothelin B receptor abolishes its ability to induce EGF receptor transactivation and contractile protein expression in vascular smooth muscle cells.
Grantcharova, E., Reusch, H.P., Grossmann, S., Eichhorst, J., Krell, H.W., Beyermann, M., Rosenthal, W. and Oksche, A.
Arteriosclerosis Thrombosis and Vascular Biology 26 (6): 1288-1296. June 2006

AKAP7.
Klussmann, E. and Rosenthal, W.
UCSD Nature Molecule Pages 4 April 2006

2005

Compartmentalized cAMP signalling regulates vasopressin-mediated water reabsorption by controlling aquaporin-2.
Henn, V., Stefan, E., Baillie, G.S., Houslay, M.D., Rosenthal, W. and Klussmann, E.
Biochemical Society Transactions 33 (Pt 6): 1316-1318. December 2005

Arrestin-independent internalization and recycling of the urotensin receptor contribute to long-lasting urotensin II-mediated vasoconstriction.
Giebing, G., Toelle, M., Juergensen, J., Eichhorst, J., Furkert, J., Beyermann, M., Neuschaefer-Rube, F., Rosenthal, W., Zidek, W., van der Giet, M. and Oksche, A.
Circulation Research 97 (7): 707-715. 30 September 2005

RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta2-adrenergic receptor to activation of ERK in HEK293B2 cells.
Lynch, M.J., Baillie, G.S., Mohamed, A., Li, X., Maisonneuve, C., Klussmann, E., van Heeke, G. and Houslay, M.D.
Journal of Biological Chemistry 280 (39): 33178-33189. 30 September 2005

The hydrophobic amino acid residues in the membrane-proximal C tail of the G protein-coupled vasopressin V2 receptor are necessary for transport-competent receptor folding.
Thielen, A., Oueslati, M., Hermosilla, R., Krause, G., Oksche, A., Rosenthal, W. and Schuelein, R.
FEBS Letters 579 (23): 5227-5235. 26 September 2005

Actin remodeling requires ERM function to facilitate AQP2 apical targeting.
Tamma, G., Klussmann, E., Oehlke, J., Krause, E., Rosenthal, W., Svelto, M. and Valenti, G.
Journal of Cell Science 118 (Pt 16): 3623-3630. 15 August 2005

The signal peptide of the rat corticotropin-releasing factor receptor 1 promotes receptor expression but is not essential for establishing a functional receptor.
Alken, M., Rutz, C., Koechl, R., Donalies, U., Oueslati, M., Furkert, J., Wietfeld, D., Hermosilla, R., Scholz, A., Beyermann, M., Rosenthal, W. and Schuelein, R.
Biochemical Journal 390 (Pt 2): 455-464. 2005

2004

Disease-causing V(2) vasopressin receptors are retained in different compartments of the early secretory pathway.
Hermosilla, R., Oueslati, M., Donalies, U., Schoenenberger, E., Krause, E., Oksche, A., Rosenthal, W. and Schuelein, R.
Traffic 5 (12): 993-1005. December 2004

Pharmacochaperones post-translationally enhance cell surface expression by increasing conformational stability of wild-type and mutant vasopressin V2 receptors.
Wueller, S., Wiesner, B., Loeffler, A., Furkert, J., Krause, G., Hermosilla, R., Schaefer, M., Schuelein, R., Rosenthal, W. and Oksche, A.
Journal of Biological Chemistry 279 (45): 47254-47263. 5 November 2004

Fluorescence resonance energy transfer analysis reveals the existence of endothelin-A and endothelin-B receptor homodimers.
Gregan, B., Schaefer, M., Rosenthal, W. and Oksche, A.
Journal of Cardiovascular Pharmacology 44 (Suppl 1): S30-S33. November 2004

Ligand-dependent differences in the internalization of endothelin A and endothelin B receptor heterodimers.
Gregan, B., Juergensen, J., Papsdorf, G., Furkert, J., Schaefer, M., Beyermann, M., Rosenthal, W. and Oksche, A.
Journal of Biological Chemistry 279 (26): 27679-27687. 25 June 2004

Identification of a novel A-kinase anchoring protein 18 isoform and evidence for its role in the vasopressin-induced aquaporin-2 shuttle in renal principal cells.
Henn, V., Edemir, B., Stefan, E., Wiesner, B., Lorenz, D., Theilig, F., Schmitt, R., Vossebein, L., Tamma, G., Beyermann, M., Krause, E., Herberg, F.W., Valenti, G., Bachmann, S., Rosenthal, W. and Klussmann, E.
Journal of Biological Chemistry 279 (25): 26654-26665. 18 June 2004

Aquaporin-1, nothing but a water channel.
Tsunoda, S.P., Wiesner, B., Lorenz, D., Rosenthal, W. and Pohl, P.
Journal of Biological Chemistry 279 (12): 11364-11367. 19 March 2004

2003

The prostaglandin E2 analogue sulprostone antagonizes vasopressin-induced antidiuresis through activation of Rho.
Tamma, G., Wiesner, B., Furkert, J., Hahm, D., Oksche, A., Schaefer, M., Valenti, G., Rosenthal, W. and Klussmann, E.
Journal of Cell Science 116 (Pt 16): 3285-3294. 15 August 2003

Renal expression of sodium transporters and aquaporin-2 in hypothyroid rats.
Schmitt, R., Klussmann, E., Kahl, T., Ellison, D.H. and Bachmann, S.
American Journal of Physiology Renal Physiology 284 (5): F1097-F1104. May 2003

cAMP-induced AQP2 translocation is associated with RhoA inhibition through RhoA phosphorylation and interaction with RhoGDI.
Tamma, G., Klussmann, E., Procino, G., Svelto, M., Rosenthal, W. and Valenti, G.
Journal of Cell Science 116 (Pt 8): 1519-1525. 15 April 2003

Cyclic AMP is sufficient for triggering the exocytic recruitment of aquaporin-2 in renal epithelial cells.
Lorenz, D., Krylov, A., Hahm, D., Hagen, V., Rosenthal, W., Pohl, P. and Maric, K.
EMBO Reports 4 (1): 88-93. January 2003

Osmolality and solute composition are strong regulators of AQP2 expression in renal principal cells.
Storm, R., Klussmann, E., Geelhaar, A., Rosenthal, W. and Maric, K.
American Journal of Physiology Renal Physiology 284 (1): F189-F198. January 2003

2002

The extracellular N terminus of the endothelin B (ETB) receptor is cleaved by a metalloprotease in an agonist-dependent process.
Grantcharova, E., Furkert, J., Reusch, H.P., Krell, H.W., Papsdorf, G., Beyermann, M., Schulein, R., Rosenthal, W. and Oksche, A.
Journal of Biological Chemistry 277 (46): 43933-43941. 15 November 2002

Functional involvement of VAMP/synaptobrevin-2 in cAMP-stimulated aquaporin 2 translocation in renal collecting duct cells.
Gouraud, S., Laera, A., Calamita, G., Carmosino, M., Procino, G., Rossetto, O., Mannucci, R., Rosenthal, W., Svelto, M. and Valenti, G.
Journal of Cell Science 115 (Pt 18): 3667-3674. 15 September 2002

Cell-biologic and functional analyses of five new Aquaporin-2 missense mutations that cause recessive nephrogenic diabetes insipidus.
Marr, N., Bichet, D.G., Hoefs, S., Savelkoul, P.J., Konings, I.B., De Mattia, F., Graat, M.P., Arthus, M.F., Lonergan, M., Fujiwara, T.M., Knoers, N.V., Landau, D., Balfe, W.J., Oksche, A., Rosenthal, W., Mueller, D., Van Os, C.H. and Deen, P.M.
Journal of the American Society of Nephrology 13 (9): 2267-2277. September 2002

The signal peptide of the G protein-coupled human endothelin B receptor is necessary for translocation of the N-terminal tail across the endoplasmic reticulum membrane.
Koechl, R., Alken, M., Rutz, C., Krause, G., Oksche, A., Rosenthal, W. and Schuelein, R.
Journal of Biological Chemistry 277 (18): 16131-16138. 3 May 2002

Variant amino acids in the extracellular loops of murine and human vasopressin V2 receptors account for differences in cell surface expression and ligand affinity.
Oksche, A., Leder, G., Valet, S., Platzer, M., Hasse, K., Geist, S., Krause, G., Rosenthal, A. and Rosenthal, W.
Molecular Endocrinology 16 (4): 799-813. April 2002

Heteroligomerization of an Aquaporin-2 mutant with wild-type Aquaporin-2 and their misrouting to late endosomes/lysosomes explains dominant nephrogenic diabetes insipidus.
Marr, N., Bichet, D.G., Lonergan, M., Arthus, M.F., Jeck, N., Seyberth, H.W., Rosenthal, W., van Os, C.H., Oksche, A. and Deen, P.M.
Human Molecular Genetics 11 (7): 779-789. 2002

2001

Rho inhibits cAMP-induced translocation of aquaporin-2 into the apical membrane of renal cells.
Tamma, G., Klussmann, E., Maric, K., Aktories, K., Svelto, M., Rosenthal, W. and Valenti, G.
American Journal of Physiology Renal Physiology 281 (6): F1092-F1101. December 2001

Ht31: the first protein kinase A anchoring protein to integrate protein kinase A and Rho signaling.
Klussmann, E., Edemir, B., Pepperle, B., Tamma, G., Henn, V., Klauschenz, E., Hundsrucker, C., Maric, K. and Rosenthal, W.
FEBS Letters 507 (3): 264-268. 2 November 2001

Role and identification of protein kinase A anchoring proteins in vasopressin-mediated aquaporin-2 translocation.
Klussmann, E. and Rosenthal, W.
Kidney International 60 (2): 446-449. August 2001

An inhibitory role of Rho in the vasopressin-mediated translocation of aquaporin-2 into cell membranes of renal principal cells.
Klussmann, E., Tamma, G., Lorenz, D., Wiesner, B., Maric, K., Hofmann, F., Aktories, K., Valenti, G. and Rosenthal, W.
Journal of Biological Chemistry 276 (23): 20451-20457. 8 June 2001

Cell volume kinetics of adherent epithelial cells measured by laser scanning reflection microscopy: determination of water permeability changes of renal principal cells.
Maric, K., Wiesner, B., Lorenz, D., Klussmann, E., Betz, T. and Rosenthal, W.
Biophysical Journal 80 (4): 1783-1790. April 2001

Functional rescue of the nephrogenic diabetes insipidus-causing vasopressin V2 receptor mutants G185C and R202C by a second site suppressor mutation.
Schuelein, R., Zuehlke, K., Krause, G. and Rosenthal, W.
Journal of Biological Chemistry 276 (11): 8384-8392. 16 March 2001

2000

Evidence for downregulation of the endothelin-B-receptor by the use of fluorescent endothelin-1 and a fusion protein consisting of the endothelin-B-receptor and the green fluorescent protein.
Oksche, A., Boese, G., Horstmeyer, A., Papsdorf, G., Furkert, J., Beyermann, M., Bienert, M. and Rosenthal, W.
Journal of Cardiovascular Pharmacology 36 (5 Suppl 1): S44-S47. November 2000

Vasopressin-induced von Willebrand factor secretion from endothelial cells involves V2 receptors and cAMP.
Kaufmann, J.E., Oksche, A., Wollheim, C.B., Guenther, G., Rosenthal, W. and Vischer, U.M.
Journal of Clinical Investigation 106 (1): 107-116. July 2000

Late endosomal/lysosomal targeting and lack of recycling of the ligand-occupied endothelin B receptor.
Oksche, A., Boese, G., Horstmeyer, A., Furkert, J., Beyermann, M., Bienert, M. and Rosenthal, W.
Molecular Pharmacology 57 (6): 1104-1113. June 2000

Molecular and conformational features of a transport-relevant domain in the C-terminal tail of the vasopressin V(2) receptor.
Krause, G., Hermosilla, R., Oksche, A., Rutz, C., Rosenthal, W. and Schuelein, R.
Molecular Pharmacology 57 (2): 232-242. February 2000

The role of conserved extracellular cysteine residues in vasopressin V2 receptor function and properties of two naturally occurring mutant receptors with additional extracellular cysteine residues.
Schuelein, R., Zuehlke, K., Oksche, A., Hermosilla, R., Furkert, J. and Rosenthal, W.
FEBS Letters 466 (1): 101-106. 21 January 2000

The mechanisms of aquaporin control in the renal collecting duct.
Klussmann, E., Maric, K. and Rosenthal, W.
Reviews of Physiology Biochemistry and Pharmacology 141 : 33-95. 2000

1999

A single negatively charged residue affects the orientation of a membrane protein in the inner membrane of Escherichia coli only when it is located adjacent to a transmembrane domain.
Rutz, C., Rosenthal, W. and Schuelein, R.
Journal of Biological Chemistry 274 (47): 33757-33763. 19 November 1999

Polarized expression of the vasopressin V2 receptor in Madin-Darby canine kidney cells.
Andersen-Beckh, B., Dehe, M., Schuelein, R., Wiesner, B., Rutz, C., Liebenhoff, U., Rosenthal, W. and Oksche, A.
Kidney International 56 (2): 517-527. August 1999

Protein kinase A anchoring proteins are required for vasopressin-mediated translocation of aquaporin-2 into cell membranes of renal principal cells.
Klussmann, E., Maric, K., Wiesner, B., Beyermann, M. and Rosenthal, W.
Journal of Biological Chemistry 274 (8): 4934-4938. 19 February 1999

1998

Polarized cell surface expression of the green fluorescent protein-tagged vasopressin V2 receptor in Madin Darby canine kidney cells.
Schuelein, R., Lorenz, D., Oksche, A., Wiesner, B., Hermosilla, R., Ebert, J. and Rosenthal, W.
FEBS Letters 441 (2): 170-176. 18 December 1998

Aquaporin-2 expression in primary cultured rat inner medullary collecting duct cells.
Maric, K., Oksche, A. and Rosenthal, W.
American Journal of Physiology 275 (5 Pt 2): F796-F801. November 1998

A dileucine sequence and an upstream glutamate residue in the intracellular carboxyl terminus of the vasopressin V2 receptor are essential for cell surface transport in COS.M6 cells.
Schuelein, R., Hermosilla, R., Oksche, A., Dehe, M., Wiesner, B., Krause, G. and Rosenthal, W.
Molecular Pharmacology 54 (3): 525-535. September 1998

A heterotrimeric G protein of the Gi family is required for cAMP-triggered trafficking of aquaporin 2 in kidney epithelial cells.
Valenti, G., Procino, G., Liebenhoff, U., Frigeri, A., Benedetti, P.A., Ahnert-Hilger, G., Nuernberg, B., Svelto, M. and Rosenthal, W.
Journal of Biological Chemistry 273 (35): 22627-22634. 28 August 1998

The molecular basis of nephrogenic diabetes insipidus.
Oksche, A. and Rosenthal, W.
Journal of Molecular Medicine 76 (5): 326-337. April 1998

Folding and cell surface expression of the vasopressin V2 receptor: requirement of the intracellular C-terminus.
Oksche, A., Dehe, M., Schuelein, R., Wiesner, B. and Rosenthal, W.
FEBS Letters 424 (1-2): 57-62. 6 March 1998

1997

Congenital nephrogenic diabetes insipidus.
Bichet, D.G., Oksche, A. and Rosenthal, W.
Journal of the American Society of Nephrology 8 (12): 1951-1958. December 1997

MUC2 gene suppression in human colorectal carcinomas and their metastases: in vitro evidence of the modulatory role of DNA methylation.
Hanski, C., Riede, E., Gratchev, A., Foss, H.D., Boehm, C., Klussmann, E., Hummel, M., Mann, B., Buhr, H.J., Stein, H., Kim, Y.S., Gum, J. and Riecken, E.O.
Laboratory Investigation 77 (6): 685-695. December 1997

Low O-acetylation of sialyl-Le(x) contributes to its overexpression in colon carcinoma metastases.
Mann, B., Klussmann, E., Vandamme-Feldhaus, V., Iwersen, M., Hanski, M.L., Riecken, E.O., Buhr, H.J., Schauer, R., Kim, Y.S. and Hanski, C.
International Journal of Cancer 72 (2): 258-264. 17 July 1997

Topology of eukaryotic multispanning transmembrane proteins: use of LacZ fusions for the localization of cytoplasmic domains in COS.M6 cells.
Schuelein, R., Rutz, C. and Rosenthal, W.
Protein Engineering 10 (6): 707-713. June 1997

Koenzym Q10 [Coenzyme Q10].
Rosenthal, W. and Brumhard, M.
Deutsche Medizinische Wochenschrift 122 (9): 278. 28 February 1997

1996

Membrane targeting and determination of transmembrane topology of the human vasopressin V2 receptor.
Schuelein, R., Rutz, C. and Rosenthal, W.
Journal of Biological Chemistry 271 (46): 28844-28852. 15 November 1996

Two novel mutations in the aquaporin-2 and the vasopressin V2 receptor genes in patients with congenital nephrogenic diabetes insipidus.
Oksche, A., Moeller, A., Dickson, J., Rosendahl, W., Rascher, W., Bichet, D.G. and Rosenthal, W.
Human Genetics 98 (5): 587-589. November 1996

Fucosyltransferase III and sialyl-Le(x) expression correlate in cultured colon carcinoma cells but not in colon carcinoma tissue.
Hanski, C., Klussmann, E., Wang, J., Boehm, C., Ogorek, D., Hanski, M.L., Krueger-Krasagakes, S., Eberle, J., Schmitt-Graeff, A. and Riecken, E.O.
Glycoconjugate Journal 13 (5): 727-733. October 1996

Vasopressin V2 receptor mutants that cause X-linked nephrogenic diabetes insipidus: analysis of expression, processing, and function.
Oksche, A., Schuelein, R., Rutz, C., Liebenhoff, U., Dickson, J., Mueller, H., Birnbaumer, M. and Rosenthal, W.
Molecular Pharmacology 50 (4): 820-828. October 1996

Properties of the human arginine vasopressin V2 receptor after site-directed mutagenesis of its putative palmitoylation site.
Schuelein, R., Liebenhoff, U., Mueller, H., Birnbaumer, M. and Rosenthal, W.
Biochemical Journal 313 (2): 611-616. 15 January 1996

1995

Identification of Rab3-, Rab5a- and synaptobrevin II-like proteins in a preparation of rat kidney vesicles containing the vasopressin-regulated water channel.
Liebenhoff, U. and Rosenthal, W.
FEBS Letters 365 (2-3): 209-213. 29 May 1995

1994

Two novel mutations in the vasopressin V2 receptor gene in patients with congenital nephrogenic diabetes insipidus.
Oksche, A., Dickson, J., Schuelein, R., Seyberth, H.W., Mueller, M., Rascher, W., Birnbaumer, M. and Rosenthal, W.
Biochemical and Biophysical Research Communications 205 (1): 552-557. 30 November 1994

Expression of MUC2-mucin in colorectal adenomas and carcinomas of different histological types.
Blanke, M., Klussmann, E., Krueger-Krasagakes, S., Schmitt-Graeff, A., Stolte, M., Bornhoeft, G., Stein, H., Xing, P.X., McKenzie, I.F., Verstijnen, C.P., Riecken, E.O. and Hanski, C.
International Journal of Cancer 59 (3): 301-306. 1 November 1994

Nature and recurrence of AVPR2 mutations in X-linked nephrogenic diabetes insipidus.
Bichet, D.G., Birnbaumer, M., Lonergan, M., Arthus, M.F., Rosenthal, W., Goodyer, P., Nivet, H., Benoit, S., Giampietro, P., Simonetti, S., Fish, A., Whitley, C.B., Jaeger, P., Gertner, J., New, M., DiBona, F.J., Kaplan, B.S., Robertson, G.L., Hendy, G.N., Fujiwara, T.M. and Morgan, K.
American Journal of Human Genetics 55 (2): 278-286. August 1994

An extracellular congenital nephrogenic diabetes insipidus mutation of the vasopressin receptor reduces cell surface expression, affinity for ligand, and coupling to the Gs/adenylyl cyclase system.
Birnbaumer, M., Gilbert, S. and Rosenthal, W.
Molecular Endocrinology 8 (7): 886-894. July 1994

Mutations in the vasopressin V2 receptor gene in families with nephrogenic diabetes insipidus and functional expression of the Q-2 mutant.
Rosenthal, W., Seibold, A., Antaramian, A., Gilbert, S., Birnbaumer, M., Bichet, D.G., Arthus, M.F. and Lonergan, M.
Cellular and Molecular Biology 40 (3): 429-436. May 1994

Stimulation of rat parietal cell function by histamine and GLP-1-(7-36) amide is mediated by Gs alpha.
Schmidtler, J., Dehne, K., Offermanns, S., Rosenthal, W., Classen, M. and Schepp, W.
American Journal of Physiology 266 (5 Pt 1): G775-G782. May 1994

1993

Altered glycosylation of the MUC-1 protein core contributes to the colon carcinoma-associated increase of mucin-bound sialyl-Lewis(x) expression.
Hanski, C., Drechsler, K., Hanisch, F.G., Sheehan, J., Manske, M., Ogorek, D., Klussmann, E., Hanski, M.L., Blank, M., Xing, P.X., McKenzie, I.F.C., Devine, P.L. and Riecken, E.O.
Cancer Research 53 (17): 4082-4088. 1 September 1993

X-linked nephrogenic diabetes insipidus mutations in North America and the Hopewell hypothesis.
Bichet, D.G., Arthus, M.F., Lonergan, M., Hendy, G.N., Paradis, A.J., Fujiwara, T.M., Morgan, K., Gregory, M.C., Rosenthal, W. and Didwania, A.
Journal of Clinical Investigation 92 (3): 1262-1268. September 1993

Cloning of the human type-2 vasopressin receptor gene.
Seibold, A., Rosenthal, W., Barberis, C. and Birnbaumer, M.
Annals of the New York Academy of Sciences 689 : 570-572. 22 July 1993

Nephrogenic diabetes insipidus. A V2 vasopressin receptor unable to stimulate adenylyl cyclase.
Rosenthal, W., Antaramian, A., Gilbert, S. and Birnbaumer, M.
Journal of Biological Chemistry 268 (18): 13030-13033. 25 June 1993

Expression cloning of the human V2 vasopressin receptor.
Barberis, C., Seibold, A., Ishido, M., Rosenthal, W. and Birnbaumer, M.
Regulatory Peptides 45 (1-2): 61-66. 29 April 1993

The vasopressin type 2 receptor gene. Chromosomal localization and its role in nephrogenic diabetes insipidus.
Seibold, A., Rosenthal, W., Bichet, D.G. and Birnbaumer, M.
Regulatory Peptides 45 (1-2): 67-71. 29 April 1993

1992

Structure and chromosomal localization of the human antidiuretic hormone receptor gene.
Seibold, A., Brabet, P., Rosenthal, W. and Birnbaumer, M.
American Journal of Human Genetics 51 (5): 1078-1083. November 1992

Molecular identification of the gene responsible for congenital nephrogenic diabetes insipidus.
Rosenthal, W., Seibold, A., Antaramian, A., Lonergan, M., Arthus, M.F., Hendy, G.N., Birnbaumer, M. and Bichet, D.G.
Nature 359 (6392): 233-235. 17 September 1992

Heterogeneity of three electrophoretically distinct Go alpha-subunits in mammalian brain.
Spicher, K., Nuernberg, B., Jaeger, B., Rosenthal, W. and Schultz, G.
FEBS Letters 307 (2): 215-218. 28 July 1992

Molecular cloning of the receptor for human antidiuretic hormone.
Birnbaumer, M., Seibold, A., Gilbert, S., Ishido, M., Barberis, C., Antaramian, A., Brabet, P. and Rosenthal, W.
Nature 357 (6376): 333-335. 28 May 1992

Pertussis toxin reverses prostaglandin E2- and somatostatin-induced inhibition of rat parietal cell H(+)-production.
Schmidtler, J., Rosenthal, W., Offermanns, S., Schusdziarra, V., Classen, M. and Schepp, W.
Cellular Signalling 4 (3): 321-329. May 1992

Characterization of GTP-binding proteins in Golgi-associated membrane vesicles from rat adipocytes.
Schuermann, A., Rosenthal, W., Schultz, G. and Joost, H.G.
Biochemical Journal 283 (Pt 3): 795-801. 1992

Exocytosis from permeabilized bovine adrenal chromaffin cells is differently modulated by guanosine 5'-[gamma-thio]triphosphate and guanosine 5'-[beta gamma-imido]triphosphate. Evidence for the involvement of various guanine nucleotide-binding proteins.
Ahnert-Hilger, G., Wegenhorst, U., Stecher, B., Spicher, K., Rosenthal, W. and Gratz, M.
Biochemical Journal 284 (Pt 2): 321-326. 1992

1991

Morphological, biochemical, and electrophysiological characterization of a clonal cell (H9c2) line from rat heart.
Hescheler, J., Meyer, R., Plant, S., Krautwurst, D., Rosenthal, W. and Schultz, G.
Circulation Research 69 (6): 1476-1486. December 1991

Identification of proteins resembling G-protein alpha subunits in locust muscle.
Soeling, A., Walther, C. and Rosenthal, W.
Biochemical and Biophysical Research Communications 180 (2): 1075-1082. 31 October 1991

Involvement of pertussis toxin-sensitive G-proteins in the hormonal inhibition of dihydropyridine-sensitive Ca2+ currents in an insulin-secreting cell line (RINm5F).
Schmidt, A., Hescheler, J., Offermanns, S., Spicher, K., Hinsch, K.D., Klinz, F.J., Codina, J., Birnbaumer, L., Gausepohl, H., Frank, R., Schultz, G. and Rosenthal, W.
Journal of Biological Chemistry 266 (27): 18025-18033. 25 September 1991

Assignment of G-protein subtypes to specific receptors inducing inhibition of calcium currents.
Kleuss, C., Hescheler, J., Ewel, C., Rosenthal, W., Schultz, G. and Wittig, B.
Nature 353 (6339): 43-48. 5 September 1991

Inhibition of voltage-dependent Ca2+ currents and activation of pertussis toxin-sensitive G-proteins via muscarinic receptors in GH3 cells.
Offermanns, S., Gollasch, M., Hescheler, J., Spicher, K., Schmidt, A., Schultz, G. and Rosenthal, W.
Molecular Endocrinology 5 (7): 995-1002. July 1991

Inhibition of Ca2+ channels via alpha 2-adrenergic and muscarinic receptors in pheochromocytoma (PC-12) cells.
Gollasch, M., Hescheler, J., Spicher, K., Klinz, F.J., Schultz, G. and Rosenthal, W.
American Journal of Physiology 260 (6 Pt 1): C1282-C1289. June 1991

Identification of the G-protein alpha-subunit encoded by alpha o2 cDNA as a 39 kDa pertussis toxin substrate.
Spicher, K., Klinz, F.J., Rudolph, U., Codina, J., Birnbaumer, L., Schultz, G. and Rosenthal, W.
Biochemical and Biophysical Research Communications 175 (2): 473-479. 15 March 1991

Evidence for opioid receptor-mediated activation of the G-proteins, Go and Gi2, in membranes of neuroblastoma x glioma (NG108-15) hybrid cells.
Offermanns, S., Schultz, G. and Rosenthal, W.
Journal of Biological Chemistry 266 (6): 3365-3368. 25 February 1991

G protein function in the ischaemic myocardium.
Will-Shahab, L., Rosenthal, W., Schulze, W. and Kuettner, I.
European Heart Journal 12 (Suppl F): 135-138. 1 January 1991

Immunocytochemical localization of G-proteins (alpha subunits) in rat heart tissue.
Schulze, W., Koessler, A., Hinsch, K.D., Rosenthal, W., Will-Shahab, L., Kuettner, I., Rada, T., Vannauer, M. and Breter, H.
European Heart Journal 12 (Suppl F): 132-134. 1 January 1991

Identification of receptor-activated G proteins with photoreactive GTP analog, [alpha-32P]GTP azidoanilide.
Offermanns, S., Schultz, G. and Rosenthal, W.
Methods in Enzymology 195 : 286-301. 1991

Improved purification and characterization of membraneous and cytosolic inositol phospholipid-specific phospholipases C from porcine brain cortex.
Hoffmann, B., Seib, C., Hoeer, A., Hoeer, D., Oberdisse, E., Rosenthal, W. and Schultz, G.
Biomedica Biochimica Acta 50 (1): 31-46. 1991

1990

A high-affinity bradykinin receptor in membranes from rat myometrium is coupled to pertussis toxin-sensitive G-proteins of the Gi family.
Liebmann, C., Offermanns, S., Spicher, K., Hinsch, K.D., Schnittler, M., Morgat, J.L., Reissmann, S., Schultz, G. and Rosenthal, W.
Biochemical and Biophysical Research Communications 167 (3): 910-917. 30 March 1990

Agonist-sensitive binding of a photoreactive GTP analog to a G-protein alpha-subunit in membranes of HL-60 cells.
Offermans, S., Schaefer, R., Hoffmann, B., Bombien, E., Spicher, K., Hinsch, K.D., Schultz, G. and Rosenthal, W.
FEBS Letters 260 (1): 14-18. 15 January 1990

Pertussis toxin-sensitive G-proteins: participation in the modulation of voltage-dependent Ca2+ channels by hormones and neurotransmitters.
Rosenthal, W., Hescheler, J., Eckert, R., Offermanns, S., Schmidt, A., Hinsch, K.D., Spicher, K., Trautwein, W. and Schultz, G.
Advances in Second Messenger and Phosphoprotein Research 24 : 89-94. 1990

Role of G proteins in calcium channel modulation.
Schultz, G., Rosenthal, W., Hescheler, J. and Trautwein, W.
Annual Review of Physiology 52 : 275-292. 1990

1989

Phosphorylation of G-protein alpha-subunits in intact adipose cells: evidence against a mediating role in insulin-dependent metabolic effects.
Joost, H.G., Schmitz-Salue, C., Hinsch, K.D., Schultz, G. and Rosenthal, W.
European Journal of Pharmacology 172 (6): 461-469. 5 December 1989

Differential sensitivity to guanine nucleotides of basal and insulin-stimulated glucose transporter activity reconstituted from adipocyte membrane fractions.
Schuermann, A., Rosenthal, W., Hinsch, K.D. and Joost, H.G.
FEBS Letters 255 (2): 259-264. 25 September 1989

Tissue distribution of beta 1- and beta 2-subunits of regulatory guanine nucleotide-binding proteins.
Hinsch, K.D., Tychowiecka, I., Gausepohl, H., Frank, R., Rosenthal, W. and Schultz, G.
Biochimica et Biophysica Acta 1013 (1): 60-67. 4 September 1989

The cytosolic G-protein alpha-subunit in human neutrophils responds to treatment with guanine nucleotides and magnesium.
Rudolph, U., Schultz, G. and Rosenthal, W.
FEBS Letters 251 (1-2): 137-142. 17 July 1989

G-protein alpha-subunits in cytosolic and membranous fractions of human neutrophils.
Rudolph, U., Koesling, D., Hinsch, K.D., Seifert, R., Bigalke, M., Schultz, G. and Rosenthal, W.
Molecular and Cellular Endocrinology 63 (1-2): 143-153. May 1989

Secretion-stimulating and secretion-inhibiting hormones stimulate high-affinity pertussis-toxin-sensitive GTPases in membranes of a pituitary cell line.
Offermanns, S., Schultz, G. and Rosenthal, W.
European Journal of Biochemistry 180 (2): 283-287. 15 March 1989

Bidirektionale hormonale Modulation spannungsabhängiger Ca2+-Kanle [Bidirectional hormonal modulation of voltage dependent ca2+ channels].
Rosenthal, W., Hescheler, J., Hinsch, K.D. and Schultz, G.
Arzneimittelforschung 39 (1A): 143-148. January 1989

1988

Immunochemical detection of the alpha-subunit of the G-protein, GZ, in membranes and cytosols of mammalian cells.
Spicher, K., Hinsch, K.D., Gausepohl, H., Frank, R., Rosenthal, W. and Schultz, G.
Biochemical and Biophysical Research Communications 157 (3): 883-890. 30 December 1988

Different types of ADP-ribose protein bonds formed by botulinum C2 toxin, botulinum ADP-ribosyltransferase C3 and pertussis toxin.
Aktories, K., Just, I. and Rosenthal, W.
Biochemical and Biophysical Research Communications 156 (1): 361-367. 14 October 1988

Adipocyte plasma membranes contain two Gi subtypes but are devoid of Go.
Hinsch, K.D., Rosenthal, W., Spicher, K., Binder, T., Gausepohl, H., Frank, R., Schultz, G. and Joost, H.G.
FEBS Letters 238 (1): 191-196. 26 September 1988

Control of voltage-dependent Ca2+ channels by G protein-coupled receptors.
Rosenthal, W., Hescheler, J., Trautwein, W. and Schultz, G.
FASEB Journal 2 (12): 2784-2790. September 1988

Degradation of inositol 1,3,4,5-tetrakisphosphates by porcine brain cytosol yields inositol 1,3,4-trisphosphate and inositol 1,4,5-trisphosphate.
Hoeer, D., Kwiatkowski, A., Seib, C., Rosenthal, W., Schultz, G. and Oberdisse, E.
Biochemical and Biophysical Research Communications 154 (2): 668-675. 29 July 1988

Activation of protein kinase C by cis- and trans-fatty acids and its potentiation by diacylglycerol.
Seifert, R., Schaechtele, C., Rosenthal, W. and Schultz, G.
Biochemical and Biophysical Research Communications 154 (1): 20-26. 15 July 1988

The role of nucleoside-diphosphate kinase reactions in G protein activation of NADPH oxidase by guanine and adenine nucleotides.
Seifert, R., Rosenthal, W., Schultz, G., Wieland, T., Gierschick, P. and Jakobs, K.H.
European Journal of Biochemistry 175 (1): 51-55. 15 July 1988

Guaninnucleotid-bindende Proteine als membranaere Signaltransduktionskomponenten und Regulatoren enzymatischer Effektoren [G-proteins and the regulation of intracellular signal-generating enzymes].
Rosenthal, W. and Schultz, G.
Klinische Wochenschrift 66 (12): 511-523. 15 June 1988

Cyclic AMP-independent, dual regulation of voltage-dependent Ca2+ currents by LHRH and somatostatin in a pituitary cell line.
Rosenthal, W., Hescheler, J., Hinsch, K.D., Spicher, K., Trautwein, W. and Schultz, G.
EMBO Journal 7 (6): 1627-1633. June 1988

A radiometric method for the determination of NADH in subpicomole amounts.
Weber, G., Rosenthal, W. and Oberdisse, E.
Journal of Biochemical and Biophysical Methods 15 (6): 295-306. April 1988

Angiotensin II-induced stimulation of voltage-dependent Ca2+ currents in an adrenal cortical cell line.
Hescheler, J., Rosenthal, W., Hinsch, K.D., Wulfern, M., Trautwein, W. and Schultz, G.
EMBO Journal 7 (3): 619-624. March 1988

Funktionen Guaninnucleotid-bindender Proteine bei der rezeptorvermittelten Modulation spannungsabhngiger Ionenkanaele [G-proteins and the modulation of voltage-dependent ion channels].
Rosenthal, W. and Schultz, G.
Klinische Wochenschrift 66 (13): 557-564. 1988

Involvement of the guanine nucleotide-binding protein, No, in the inhibitory regulation of neuronal calcium channels.
Hescheler, J., Rosenthal, W., Wulfern, M., Tang, M., Yajima, M., Trautwein, W. and Schultz, G.
Advances in Second Messenger and Phosphoprotein Research 21 : 165-174. 1988

Receptor- and G-protein-mediated modulations of voltage-dependent calcium channels.
Rosenthal, W., Hescheler, J., Trautwein, W. and Schultz, G.
Cold Spring Harbor Symposia on Quantitative Biology 53 (Pt 1): 247-254. 1988

1987

Resolution of transducin subunits by chromatography on blue sepharose.
Kleuss, C., Pallast, M., Brendel, S., Rosenthal, W. and Schultz, G.
Journal of chromatography 407 : 281-289. 16 October 1987

Modulations of voltage-dependent ion channels by extracellular signals.
Rosenthal, W. and Schultz, G.
Trends in Pharmacological Sciences 8 (9): 351-354. September 1987

In vitro synthesis of 32P-labelled phosphatidylinositol 4,5-bisphosphate and its hydrolysis by smooth muscle membrane-bound phospholipase C.
Fuelle, H.J., Hoeer, D., Lache, W., Rosenthal, W., Schultz, G. and Oberdisse, E.
Biochemical and Biophysical Research Communications 145 (2): 673-679. 15 June 1987

The GTP-binding protein, Go, regulates neuronal calcium channels.
Hescheler, J., Rosenthal, W., Trautwein, W. and Schultz, G.
Nature 325 (6103): 445-447. 29 January 1987

NADP efficiently inhibits endogenous but not pertussis toxin-catalyzed covalent modification of membrane proteins incubated with NAD.
Rosenthal, W., Binder, T. and Schultz, G.
FEBS Letters 211 (2): 137-143. 26 January 1987

1986

Identification and characterization of the 35-kDa beta subunit of guanine-nucleotide-binding proteins by an antiserum raised against transducin.
Rosenthal, W., Koesling, D., Rudolph, U., Kleuss, C., Pallast, M., Yajima, M. and Schultz, G.
European Journal of Biochemistry 158 (2): 255-263. 15 July 1986

Guanine nucleotides stimulate NADPH oxidase in membranes of human neutrophils.
Seifert, R., Rosenthal, W. and Schultz, G.
FEBS Letters 205 (1): 161-165. 1986

1985

Characterization by two-dimensional peptide mapping of the gamma subunits of Ns and Ni, the regulatory proteins of adenylyl cyclase, and of transducin, the guanine nucleotide-binding protein of rod outer segments of the eye.
Hildebrandt, J.D., Codina, J., Rosenthal, W., Birnbaumer, L., Neer, E.J., Yamazaki, A. and Bitensky, M.W.
Journal of Biological Chemistry 260 (27): 14867-14872. 25 November 1985

Prinzipien der transmembranaeren Signalumsetzung bei der Wirkung von Hormonen und Neurotransmittern [Principles of transmembranous signal transduction in the action of hormones and neurotransmitters].
Schultz, G. and Rosenthal, W.
Arzneimittelforschung 35 (12A): 1879-1885. 1985

Properties of human erythrocyte Ns and Ni, the regulatory components of adenylate cyclase, as purified without regulatory ligands.
Hildebrandt, J.D., Codina, J., Rosenthal, W., Sunyer, T., Iyengar, R. and Birnbaumer, L.
Advances in Cyclic Nucleotide and Protein Phosphorylation Research 19 : 87-101. 1985

Purification of Ns and Ni, the coupling proteins of hormone-sensitive adenylyl cyclases without intervention of activating regulatory ligands.
Codina, J., Rosenthal, W., Hildebrandt, J.D., Birnbaumer, L. and Sekura, R.D.
Methods in Enzymology 109 : 446-465. 1985