American Journal of Human Genetics
The genetic ancestry of modern Indus Valley populations from Northwest India.
Pathak, A.K., Kadian, A., Kushniarevich, A., Montinaro, F., Mondal, M., Ongaro, L., Singh, M., Kumar, P., Rai, N., Parik, J., Metspalu, E., Rootsi, S., Pagani, L., Kivisild, T., Metspalu, M., Chaubey, G. and Villems, R.
American Journal of Human Genetics 103
(6): 918-929.
6 December 2018
Annals of Translational Medicine
Localized irradiation of mouse legs using an image-guided robotic linear accelerator.
Kufeld, M., Escobar, H., Marg, A., Pasemann, D., Budach, V. and Spuler, S.
Annals of Translational Medicine 5
(7): 156.
April 2017
Arteriosclerosis Thrombosis and Vascular Biology
Long-term prevention of congenital thrombotic thrombocytopenic purpura in ADAMTS13 knockout mice by sleeping beauty transposon-mediated gene therapy.
Verhenne, S., Vandeputte, N., Pareyn, I., Izsvák, Z., Rottensteiner, H., Deckmyn, H., De Meyer, S.F. and Vanhoorelbeke, K.
Arteriosclerosis Thrombosis and Vascular Biology 37
(5): 836-844.
May 2017
BMC Biotechnology
Novel strong tissue specific promoter for gene expression in human germ cells.
Kuzmin, D., Gogvadze, E., Kholodenko, R., Grzela, D.P., Mityaev, M., Vinogradova, T., Kopantzev, E., Malakhova, G., Suntsova, M., Sokov, D., Ivics, Z. and Buzdin, A.
BMC Biotechnology 10
(1): 58.
17 August 2010
BioEssays
Pluripotency and the endogenous retrovirus HERVH: Conflict or serendipity?
Izsvák, Z., Wang, J., Singh, M., Mager, D.L. and Hurst, L.D.
BioEssays 38
(1): 109-117.
January 2016
Translating Sleeping Beauty transposition into cellular therapies: Victories and challenges.
Izsvak, Z., Hackett, P.B., Cooper, L.J. and Ivics, Z.
BioEssays 32
(9): 756-767.
September 2010
BioMed Research International
Antiangiogenic and neurogenic activities of Sleeping Beauty-mediated PEDF-transfected RPE cells in vitro and in vivo.
Johnen, S., Djalali-Talab, Y., Kazanskaya, O., Möller, T., Harmening, N., Kropp, M., Izsvák, Z., Walter, P. and Thumann, G.
BioMed Research International 2015
: 863845.
2015
Biochemical Journal
Positive co-operative interaction between the subunits of CeqI restriction endonuclease.
Jobbagy, Z., Izsvak, Z. and Duda, E.
Biochemical Journal 286
: 85-88.
15 August 1992
‘Star’ activity and complete loss of specificity of CeqI endonuclease.
Izsvak, Z. and Duda, E.
Biochemical Journal 258
(1): 301-303.
February 1989
Biochemistry and Cell Biology
Repetitive elements and their genetic applications in zebrafish.
Izsvak, Z., Ivics, Z. and Hackett, P.B.
Biochemistry and Cell Biology 75
(5): 507-523.
1 October 1997
Biomedicines
GMP-grade manufacturing and quality control of a non-virally engineered advanced therapy medicinal product for personalized treatment of age-related macular degeneration.
Kropp, M., Harmening, N., Bascuas, T., Johnen, S., De Clerck, E., Fernández, V., Ronchetti, M., Cadossi, R., Zanini, C., Scherman, D., Ivics, Z., Marie, C., Izsvák, Z. and Thumann, G.
Biomedicines 10
(11): 2777.
November 2022
Biomolecules
Enhanced biosafety of the Sleeping Beauty transposon system by using mRNA as source of transposase to efficiently and stably transfect retinal pigment epithelial cells.
Harmening, N., Johnen, S., Izsvák, Z., Ivics, Z., Kropp, M., Bascuas, T., Walter, P., Kreis, A., Pajic, B. and Thumann, G.
Biomolecules 13
(4): 658.
7 April 2023
Biotechniques
Family of plasmid vectors for the expression of beta-galactosidase fusion proteins in eukaryotic cells.
Ivics, Z. and Izsvak, Z.
Biotechniques 22
: 254-258.
1 February 1997
Two-stage ligation-mediated PCR enhances the detection of integrated transgenic DNA.
Izsvak, Z. and Ivics, Z.
Biotechniques 15, 5
: 814-818.
1 November 1993
Biotechnology Journal
Gateway compatible transposon vector to genetically modify human embryonic kidney and adipose-derived stromal cells.
Petrakis, S., Rasko, T., Mates, L., Ivics, Z., Izsvak, Z., Kouzi-Koliakou, K. and Koliakos, G.
Biotechnology Journal 7
(7): 891-897.
July 2012
Blood
In vivo transduction of primitive mobilized hematopoietic stem cells after intravenous injection of integrating adenovirus vectors.
Richter, M., Saydaminova, K., Yumul, R., Krishnan, R., Liu, J., Nagy, E.E., Singh, M., Izsvák, Z., Cattaneo, R., Uckert, W., Palmer, D., Ng, P., Haworth, K.G., Kiem, H.P., Ehrhardt, A., Papayannopoulou, T. and Lieber, A.
Blood 128
(18): 2206-2217.
3 November 2016
Emerging potential of transposons for gene therapy and generation of induced pluripotent stem cells.
Vandendriessche, T., Ivics, Z., Izsvak, Z. and Chuah, M.K.
Blood 114
(8): 1461-1468.
20 August 2009
Stable gene transfer and expression in cord blood-derived CD34+ hematopoietic stem and progenitor cells by a hyperactive Sleeping Beauty transposon system.
Xue, X., Huang, X., Nodland, S.E., Mates, L., Ma, L., Izsvak, Z., Ivics, Z., Lebien, T.W., McIvor, R.S., Wagner, J.E. and Zhou, X.
Blood 114
(7): 1319-1330.
13 August 2009
Blood Advances
Single-dose MGTA-145/plerixafor leads to efficient mobilization and in vivo transduction of HSCs with thalassemia correction in mice.
Li, C., Goncalves, K.A., Raskó, T., Pande, A., Gil, S., Liu, Z., Izsvák, Z., Papayannopoulou, T., Davis, J.C., Kiem, H.P. and Lieber, A.
Blood Advances 5
(5): 1239-1249.
9 March 2021
Cell
Molecular reconstruction of Sleeping Beauty, a Tc1-like transposon from fish, and its transposition in human cells.
Ivics, Z., Hackett, P.B., Plasterk, R.H. and Izsvak, Z.
Cell 91
(4): 501-510.
14 November 1997
Cell Reports
Recapitulating early human development with 8C-like cells.
Yu, X., Liang, S., Chen, M., Yu, H., Li, R., Qu, Y., Kong, X., Guo, R., Zheng, R., Izsvak, Z., Sun, C., Yang, M. and Wang, J.
Cell Reports 39
(12): 110994.
21 June 2022
Cell Stem Cell
Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells.
Yang, M., Yu, H., Yu, X., Liang, S., Hu, Y., Luo, Y., Izsvák, Z., Sun, C. and Wang, J.
Cell Stem Cell 29
(3): 400-418.e13.
3 March 2022
Human iPSC-derived neural progenitors are an effective drug discovery model for neurological mtDNA disorders.
Lorenz, C., Lesimple, P., Bukowiecki, R., Zink, A., Inak, G., Mlody, B., Singh, M., Semtner, M., Mah, N., Auré, K., Leong, M., Zabiegalov, O., Lyras, E.M., Pfiffer, V., Fauler, B., Eichhorst, J., Wiesner, B., Huebner, N., Priller, J., Mielke, T., Meierhofer, D., Izsvák, Z., Meier, J.C., Bouillaud, F., Adjaye, J., Schuelke, M., Wanker, E.E., Lombès, A. and Prigione, A.
Cell Stem Cell 20
(5): 659-674.e9.
4 May 2017
Cell and Gene Therapy Insights
Sleeping Beauty transposon vectors for therapeutic applications: advances and challenges.
Narayanavari, S.A. and Izsvák, Z.
Cell and Gene Therapy Insights 3
(2): 131-158.
30 March 2017
Cellular and Molecular Life Sciences
Molecular domestication of transposable elements: From detrimental parasites to useful host genes.
Sinzelle, L., Izsvak, Z. and Ivics, Z.
Cellular and Molecular Life Sciences 66
(6): 1073-1093.
March 2009
DNA transposons in vertebrate functional genomics.
Miskey, C., Izsvak, Z., Kawakami, K. and Ivics, Z.
Cellular and Molecular Life Sciences 62
(6): 629-641.
March 2005
Circulation
Disturbed placental imprinting in preeclampsia leads to altered expression of DLX5, a human-specific early trophoblast marker.
Zadora, J., Singh, M., Herse, F., Przybyl, L., Haase, N., Golic, M., Yung, H.W., Huppertz, B., Cartwright, J.E., Whitley, G.S., Johnsen, G.M., Levi, G., Isbruch, A., Schulz, H., Luft, F.C., Müller, D.N., Staff, A.C., Hurst, L.D., Dechend, R. and Izsvák, Z.
Circulation 136
(19): 1824-1839.
7 November 2017
Critical Reviews in Biochemistry and Molecular Biology
Going non-viral: the Sleeping Beauty transposon system breaks on through to the clinical side.
Hudecek, M., Izsvák, Z., Johnen, S., Renner, M., Thumann, G. and Ivics, Z.
Critical Reviews in Biochemistry and Molecular Biology 52
(4): 355-380.
August 2017
Sleeping Beauty transposition: from biology to applications.
Narayanavari, S.A., Chilkunda, S.S., Ivics, Z. and Izsvák, Z.
Critical Reviews in Biochemistry and Molecular Biology 52
(1): 18-44.
January 2017
Current Gene Therapy
Recombinase technology for gene therapy.
Ivics, Z.
Current Gene Therapy 11
(5): 331.
1 October 2011
Transposons for gene therapy!
Ivics, Z. and Izsvak, Z.
Current Gene Therapy 6
(5): 593-607.
October 2006
Current Issues in Molecular Biology
The Sleeping Beauty transposable element: evolution, regulation and genetic applications.
Ivics, Z., Kaufman, C.D., Zayed, H., Miskey, C., Walisko, O. and Izsvak, Z.
Current Issues in Molecular Biology 6
(1): 43-55.
1 January 2004
Current Opinion in Virology
How to tame an endogenous retrovirus: HERVH and the evolution of human pluripotency.
Römer, C., Singh, M., Hurst, L.D. and Izsvák, Z.
Current Opinion in Virology 25
: 49-58.
August 2017
Developmental Dynamics
Germline transgenesis of the chordate Ciona intestinalis with hyperactive variants of sleeping beauty transposable element.
Hozumi, A., Mita, K., Miskey, C., Mates, L., Izsvak, Z., Ivics, Z., Satake, H. and Sasakura, Y.
Developmental Dynamics 242
(1): 30-43.
January 2013
European Journal of Medical Genetics
Improved molecular platform for the gene therapy of rare diseases by liver protein secretion.
Quiviger, M., Giannakopoulos, A., Verhenne, S., Marie, C., Stavrou, E.F., Vanhoorelbeke, K., Izsvák, Z., De Meyer, S.F., Athanassiadou, A. and Scherman, D.
European Journal of Medical Genetics 61
(11): 723-728.
November 2018
Experimental Cell Research
Generation of mouse induced pluripotent stem cells from different genetic backgrounds using Sleeping beauty transposon mediated gene transfer.
Muenthaisong, S., Ujhelly, O., Polgar, Z., Varga, E., Ivics, Z., Pirity, M.K. and Dinnyes, A.
Experimental Cell Research 318
(19): 2482-2489.
15 November 2012
Expert Opinion on Biological Therapy
The Sleeping Beauty transposon system for clinical applications.
Swierczek, M., Izsvak, Z. and Ivics, Z.
Expert Opinion on Biological Therapy 12
(2): 139-153.
February 2012
FASEB Journal
Transposon-mediated transgenesis, transgenic rescue, and tissue-specific gene expression in rodents and rabbits.
Katter, K., Geurts, A.M., Hoffmann, O., Mátés, L., Landa, V., Hiripi, L., Moreno, C., Lazar, J., Bashir, S., Zidek, V., Popova, E., Jerchow, B., Becker, K., Devaraj, A., Walter, I., Grzybowksi, M., Corbett, M., Filho, A.R., Hodges, M.R., Bader, M., Ivics, Z., Jacob, H.J., Pravenec, M., Bosze, Z., Rülicke, T. and Izsvák, Z.
FASEB Journal 27
(3): 930-941.
March 2013
Gene
Functional indications for transposase domestications - characterization of the human piggyBac transposase derived (PGBD) activities.
Kolacsek, O., Wachtl, G., Fóthi, Á., Schamberger, A., Sándor, S., Pergel, E., Varga, N., Raskó, T., Izsvák, Z., Apáti, Á. and Orbán, T.I.
Gene 834
: 146609.
5 August 2022
Gene Therapy
The hyperactive Sleeping Beauty transposase SB100X improves the genetic modification of T cells to express a chimeric antigen receptor.
Jin, Z., Maiti, S., Huls, H., Singh, H., Olivares, S., Mates, L., Izsvak, Z., Ivics, Z., Lee, D.A., Champlin, R.E. and Cooper, L.J.
Gene Therapy 18
(9): 849-856.
September 2011
Genome Biology
Ten things you should know about transposable elements.
Bourque, G., Burns, K.H., Gehring, M., Gorbunova, V., Seluanov, A., Hammell, M., Imbeault, M., Izsvák, Z., Levin, H.L., Macfarlan, T.S., Mager, D.L. and Feschotte, C.
Genome Biology 19
(1): 199.
19 November 2018
Genomic parasites and genome evolution.
Ivics, Z.
Genome Biology 10
(4): 306.
15 April 2009
Technology transfer from worms and flies to vertebrates: transposition-based genome manipulations and their future perspectives.
Mates, L., Izsvak, Z. and Ivics, Z.
Genome Biology 8 Suppl 1
: S1.
31 October 2007
Genome Dynamics and Stability
Interactions of transposons with the cellular DNA repair machinery.
Izsvak, Z., Wang, Y. and Ivics, Z.
Genome Dynamics and Stability 4
: 133-176.
2009
Transposon-host cell interactions in the regulation of Sleeping Beauty transposition.
Walisko, O., Jursch, T., Izsvak, Z. and Ivics, Z.
Genome Dynamics and Stability 4
: 109-132.
2009
Genome Editing in Stem Cells and Regenerative Biology
Genome engineering using Sleeping Beauty transposition in vertebrates.
Chilkunda, S.S., Raghunathan, V., Narayanavari, S.A., Ivics, Z. and Izsvák, Z.
In:
Genome editing and engineering.
Cambridge University Press, Cambridge, 249-269.
ISBN 9781316756300
July 2018
Genome Research
Retrotransposition creates sloping shores: a graded influence of hypomethylated CpG islands on flanking CpG sites.
Grandi, F.C., Rosser, J.M., Newkirk, S.J., Yin, J., Jiang, X., Xing, Z., Whitmore, L., Bashir, S., Ivics, Z., Izsvák, Z., Ye, P., Yu, Y.E. and An, W.
Genome Research 25
(8): 1135-1146.
August 2015
A novel active endogenous retrovirus family contributes to genome variability in rat inbred strains.
Wang, Y., Liska, F., Gosele, C., Sedova, L., Kren, V., Krenova, D., Ivics, Z., Huebner, N. and Izsvak, Z.
Genome Research 20
(1): 19-27.
January 2010
Histochemistry and Cell Biology
Placental DAPK1 and autophagy marker LC3B-II are dysregulated by TNF-α in a gestational age-dependent manner.
Prokesch, A., Blaschitz, A., Bauer, T., Moser, G., Hiden, U., Zadora, J., Dechend, R., Herse, F. and Gauster, M.
Histochemistry and Cell Biology 147
(6): 695-705.
June 2017
Human Gene Therapy
Efficient non-viral T cell engineering by Sleeping Beauty minicircles diminishing DNA toxicity and miRNAs silencing the endogenous TCR.
Clauss, J., Obenaus, M., Miskey, C., Ivics, Z., Izsvák, Z., Uckert, W. and Bunse, M.
Human Gene Therapy 29
(5): 569-584.
May 2018
Wide awake and ready to move: 20 years of non-viral therapeutic genome engineering with the Sleeping Beauty transposon system.
Hodge, R., Narayanavari, S., Izsvák, Z. and Ivics, Z.
Human Gene Therapy 28
(10): 842-855.
1 October 2017
Nonviral gene delivery with the Sleeping Beauty transposon system.
Ivics, Z. and Izsvak, Z.
Human Gene Therapy 22
(9): 1043-1051.
September 2011
Herpes simplex virus/Sleeping Beauty Vector-based embryonic gene transfer using the HSB5 mutant: loss of apparent transposition hyperactivity in vivo.
de Silva, S., Mastrangelo, M.A., Lotta, L.T., Burris, C.A., Izsvak, Z., Ivics, Z. and Bowers, W.J.
Human Gene Therapy 21
(11): 1603-1613.
19 November 2010
Human Gene Therapy Clinical Development
Transposon-based, targeted ex vivo gene therapy to treat age-related macular degeneration (TargetAMD).
Thumann, G., Perdikomati-Dahmen, M., Izsvák, Z., Ivics, Z., Garcia Layana, A., Ronchetti, M., Petrovski, G., Scherman, D., Aranda, P., Pouillot, S., Binder, S., Johnen, S. and van den Berg, J.
Human Gene Therapy Clinical Development 26
(2): 97-100.
18 June 2015
Human Gene Therapy Methods
Excision efficiency is not strongly coupled to transgenic rate: cell type dependent transposition efficiency of Sleeping Beauty and piggyBac DNA transposons.
Kolacsek, O., Erdei, Z., Apáti, A., Sándor, S., Izsvák, Z., Ivics, Z., Sarkadi, B. and Orbán, T.I.
Human Gene Therapy Methods 25
(4): 241-252.
August 2014
Hypertension
Downregulation of Plzf gene ameliorates metabolic and cardiac traits in the spontaneously hypertensive rat.
Liška, F., Landa, V., Zidek, V., Mlejnek, P., Šilhavý, J., Šimáková, M., Strnad, H., Trnovská, J., Škop, V., Kazdová, L., Starker, C.G., Voytas, D.F., Izsvák, Z., Mancini, M., Šeda, O., Křen, V. and Pravenec, M.
Hypertension 69
(6): 1084-1091.
June 2017
International Journal of Biochemistry and Cell Biology
Cloning and characterization of the genes of the CeqI restriction-modification system.
Izsvak, Z., Jobbagy, Z., Takacs, I. and Duda, E.
International Journal of Biochemistry and Cell Biology 29
: 895-900.
1 June 1997
International Journal of Molecular Sciences
HMGXB4 targets Sleeping Beauty transposition to germinal stem cells.
Devaraj, A., Singh, M., Narayanavari, S.A., Yong, G., Chen, J., Wang, J., Becker, M., Walisko, O., Schorn, A., Cseresznyés, Z., Raskó, T., Radscheit, K., Selbach, M., Ivics, Z. and Izsvak, Z.
International Journal of Molecular Sciences 24
(8): 7283.
14 April 2023
Molecular and functional characterization of BDNF-overexpressing human retinal pigment epithelial cells established by sleeping beauty transposon-mediated gene transfer.
Mattern, L., Otten, K., Miskey, C., Fuest, M., Izsvák, Z., Ivics, Z., Walter, P., Thumann, G. and Johnen, S.
International Journal of Molecular Sciences 23
(21): 12982.
1 November 2022
Analyses of circRNA expression throughout the light-dark cycle reveal a strong regulation of (Cdr1as), associated with light entrainment in the SCN.
Ivanov, A., Mattei, D., Radscheit, K., Compagnion, A.C., Pett, J.P., Herzel, H.P., Paolicelli, R.C., Piwecka, M., Meyer, U. and Beule, D.
International Journal of Molecular Sciences 23
(20): 12347.
October 2022
International Review of Cell and Molecular Biology
Unique functions of repetitive transcriptomes.
Schumann, G.G., Gogvadze, E.V., Osanai-Futahashi, M., Kuroki, A., Muenk, C., Fujiwara, H., Ivics, Z. and Buzdin, A.A.
International Review of Cell and Molecular Biology 285
: 115-188.
2010
Investigative Ophthalmology & Visual Science
Sleeping Beauty transposon-mediated transfection of retinal and iris pigment epithelial cells.
Johnen, S., Izsvak, Z., Stocker, M., Harmening, N., Salz, A.K., Walter, P. and Thumann, G.
Investigative Ophthalmology & Visual Science 53
(8): 4787-4796.
18 July 2012
JCI Insight
Curative in vivo hematopoietic stem cell gene therapy of murine thalassemia using large regulatory elements.
Wang, H., Georgakopoulou, A., Li, C., Liu, Z., Gil, S., Bashyam, A., Yannaki, E., Anagnostopoulos, A., Pande, A., Izsvák, Z., Papayannopoulou, T. and Lieber, A.
JCI Insight 5
(16): e139538.
20 August 2020
Human endogenous retrovirus HERV-K(HML-2) RNA causes neurodegeneration through Toll-like receptors.
Dembny, P., Newman, A.G., Singh, M., Hinz, M., Szczepek, M., Krüger, C., Adalbert, R., Dzaye, O., Trimbuch, T., Wallach, T., Kleinau, G., Derkow, K., Richard, B.C., Schipke, C., Scheidereit, C., Stachelscheid, H., Golenbock, D., Peters, O., Coleman, M., Heppner, F.L., Scheerer, P., Tarabykin, V., Ruprecht, K., Izsvák, Z., Mayer, J. and Lehnardt, S.
JCI Insight 5
(7): e131093.
9 April 2020
Journal of Biological Chemistry
Involvement of a bifunctional, paired-like DNA-binding domain and a transpositional enhancer in Sleeping Beauty transposition.
Izsvak, Z., Khare, D., Behlke, J., Heinemann, U., Plasterk, R.H. and Ivics, Z.
Journal of Biological Chemistry 277
(37): 34581-34588.
13 September 2002
Journal of Biotechnology
A DNA-transposon-based approach to functional screening in neural stem cells.
Albieri, I., Onorati, M., Calabrese, G., Moiana, A., Biasci, D., Badaloni, A., Camnasio, S., Spiliotopoulos, D., Ivics, Z., Cattaneo, E. and Consalez, G.G.
Journal of Biotechnology 150
(1): 11-21.
1 October 2010
Journal of Bone and Mineral Research
Efficient generation of osteoclasts from human induced pluripotent stem cells and functional investigations of lethal CLCN7-related osteopetrosis.
Rössler, U., Hennig, A.F., Stelzer, N., Bose, S., Kopp, J., Søe, K., Cyganek, L., Zifarelli, G., Ali, S., von der Hagen, M., Strässler, E.T., Hahn, G., Pusch, M., Stauber, T., Izsvák, Z., Gossen, M., Stachelscheid, H. and Kornak, U.
Journal of Bone and Mineral Research 36
(8): 1621-1635.
August 2021
Journal of Clinical Investigation
Staring at the onco-exaptation: the two-faced medley of an ancient retrovirus, HERVH.
Singh, M., Kondraskhina, A.M., Hurst, L.D. and Izsvák, Z.
Journal of Clinical Investigation 133
(14): e172278.
17 July 2023
In vivo hematopoietic stem cell gene therapy ameliorates murine thalassemia intermedia.
Wang, H., Georgakopoulou, A., Psatha, N., Li, C., Capsali, C., Samal, H.B., Anagnostopoulos, A., Ehrhardt, A., Izsvák, Z., Papayannopoulou, T., Yannaki, E. and Lieber, A.
Journal of Clinical Investigation 129
(2): 598-615.
1 February 2019
Human satellite cells have regenerative capacity and are genetically manipulable.
Marg, A., Escobar, H., Gloy, S., Kufeld, M., Zacher, J., Spuler, A., Birchmeier, C., Izsvák, Z. and Spuler, S.
Journal of Clinical Investigation 124
(10): 4257-4265.
1 October 2014
Journal of Clinical Medicine
Advancing research and treatment: an overview of clinical trials in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and future perspectives.
Seton, K.A., Espejo-Oltra, J.A., Giménez-Orenga, K., Haagmans, R., Ramadan, D.J. and Mehlsen, J.
Journal of Clinical Medicine 13
(2): 325.
6 January 2024
Journal of Molecular Biology
Schizophrenia risk candidate protein ZNF804A interacts with STAT2 and influences interferon-mediated gene transcription in mammalian cells.
Klockmeier, K., Silva Ramos, E., Raskó, T., Martí Pastor, A. and Wanker, E.E.
Journal of Molecular Biology 433
(19): 167184.
17 September 2021
Common physical properties of DNA affecting target site selection of Sleeping Beauty and other Tc1/mariner transposable elements.
Vigdal, T.J., Kaufman, C.D., Izsvak, Z., Voytas, D.F. and Ivics, Z.
Journal of Molecular Biology 323
(3): 441-452.
25 October 2002
Sleeping Beauty, a wide host-range transposon vector for genetic transformation in vertebrates.
Izsvak, Z., Ivics, Z. and Plasterk, R.H.
Journal of Molecular Biology 302
: 93-102.
8 September 2000
Journal of Molecular Evolution
Short inverted-repeat transposable elements in teleost fish and implications for a mechanism of their amplification.
Izsvak, Z., Ivics, Z., Shimoda, N., Mohn, D., Okamoto, H. and Hackett, P.B.
Journal of Molecular Evolution 48
: 13-21.
1 January 1999
Journal of Molecular Medicine
Targeted gene insertion for molecular medicine.
Voigt, K., Izsvak, Z. and Ivics, Z.
Journal of Molecular Medicine 86
(11): 1205-1219.
November 2008
Journal of Neuroscience
Loss of Piccolo function in rats induces cerebellar network dysfunction and Pontocerebellar Hypoplasia type 3-like phenotypes.
Falck, J., Bruns, C., Hoffmann-Conaway, S., Straub, I., Plautz, E.J., Orlando, M., Munawar, H., Rivalan, M., Winter, Y., Izsvák, Z., Schmitz, D., Hamra, F.K., Hallermann, S., Curtis Garner, C. and Ackermann, F.
Journal of Neuroscience 40
(14): 2943-2959.
1 April 2020
A multiple Piccolino-RIBEYE interaction supports plate-shaped synaptic ribbons in retinal neurons.
Müller, T.M., Gierke, K., Joachimsthaler, A., Sticht, H., Izsvák, Z., Hamra, F.K., Fejtová, A., Ackermann, F., Garner, C.C., Kremers, J., Brandstätter, J.H. and Regus-Leidig, H.
Journal of Neuroscience 39
(14): 2606-2619.
3 April 2019
Journal of RNAi and Gene Silencing
Frog Prince transposon-based RNAi vectors mediate efficient gene knockdown in human cells.
Kaufman, C.D., Izsvak, Z., Katzer, A. and Ivics, Z.
Journal of RNAi and Gene Silencing 1
(2): 97-104.
October 2005
Journal of Thrombosis and Haemostasis
High and long-term von Willebrand factor expression after Sleeping Beauty transposon-mediated gene therapy in a mouse model of severe von Willebrand disease.
Portier, I., Vanhoorelbeke, K., Verhenne, S., Pareyn, I., Vandeputte, N., Deckmyn, H., Goldenberg, D.S., Samal, H.B., Singh, M., Ivics, Z., Izsvák, Z. and De Meyer, S.F.
Journal of Thrombosis and Haemostasis 16
(3): 592-604.
March 2018
Journal of Visualized Experiments
Isolation, culture, and genetic engineering of mammalian primary pigment epithelial cells for non-viral gene therapy.
Bascuas, T., Kropp, M., Harmening, N., Wong, B.M., Johnen, S., Izsvák, Z. and Thumann, G.
Journal of Visualized Experiments
(168): e62145.
26 February 2021
Electroporation-based genetic modification of primary human pigment epithelial cells using the Sleeping Beauty transposon system.
Johnen, S., Harmening, N., Marie, C., Scherman, D., Izsvák, Z., Ivics, Z., Walter, P. and Thumann, G.
Journal of Visualized Experiments
(168): e61987.
February 2021
Induction and analysis of oxidative stress in Sleeping Beauty transposon-transfected human retinal pigment epithelial cells.
Bascuas, T., Kropp, M., Harmening, N., Asrih, M., Izsvák, Z. and Thumann, G.
Journal of Visualized Experiments 2020
(166): e61957.
11 December 2020
Life Medicine
Retrotransposon: a versatile player in human preimplantation development and health.
Qu, Y., Izsvák, Z. and Wang, J.
Life Medicine 2
(1): 1-3.
February 2023
Methods
Sleeping Beauty transposon mutagenesis of the rat genome in spermatogonial stem cells.
Ivics, Z., Izsvak, Z., Chapman, K.M. and Hamra, F.K.
Methods 53
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April 2011
Efficient stable gene transfer into human cells by Sleeping Beauty transposon vectors.
Izsvak, Z., Chuah, M.K., VandenDriessche, T. and Ivics, Z.
Methods 49
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November 2009
Methods in Molecular Biology
The sleeping beauty transposon toolbox.
Ammar, I., Izsvak, Z. and Ivics, Z.
Methods in Molecular Biology 859
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31 January 2012
Insertional engineering of chromosomes with Sleeping Beauty transposition: an overview.
Grabundzija, I., Izsvak, Z. and Ivics, Z.
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Transposable elements as plasmid-based vectors for long-term gene transfer into tumors.
Ohlfest, J.R., Ivics, Z. and Izsvak, Z.
Methods in Molecular Biology 542
(Part 2): 105-116.
2009
Insertional mutagenesis of the mouse germline with Sleeping Beauty transposition.
Takeda, J., Izsvak, Z. and Ivics, Z.
Methods in Molecular Biology 435
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2008
Microbiology Spectrum
Sleeping Beauty transposition.
Ivics, Z. and Izsvák, Z.
Microbiology Spectrum 3
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April 2015
Mobile DNA
Regulation of DNA transposition by CpG methylation and chromatin structure in human cells.
Jursch, T., Miskey, C., Izsvák, Z. and Ivics, Z.
Mobile DNA 4
(1): 15.
15 May 2013
Cell division promotes efficient retrotransposition in a stable L1 reporter cell line.
Xie, Y., Mates, L., Ivics, Z., Izsvák, Z., Martin, S.L. and An, W.
Mobile DNA 4
(1): 1-10.
6 March 2013
Reliable transgene-independent method for determining Sleeping Beauty transposon copy numbers.
Kolacsek, O., Krizsik, V., Schamberger, A., Erdei, Z., Apati, A., Varady, G., Mates, L., Izsvak, Z., Ivics, Z., Sarkadi, B. and Orban, T.I.
Mobile DNA 2
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3 March 2011
The expanding universe of transposon technologies for gene and cell engineering.
Ivics, Z. and Izsvak, Z.
Mobile DNA 1
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7 December 2010
Mobile DNA III
Sleeping Beauty transposition.
Ivics, Z. and Izsvák, Z.
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ASM Press, Washington, DC, 851-872.
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Molecular Biology and Evolution
A novel gene controls a new structure: piggyBac transposable element-derived 1, unique to mammals, controls mammal-specific neuronal paraspeckles.
Raskó, T., Pande, A., Radscheit, K., Zink, A., Singh, M., Sommer, C., Wachtl, G., Kolacsek, O., Inak, G., Szvetnik, A., Petrakis, S., Bunse, M., Bansal, V., Selbach, M., Orbán, T.I., Prigione, A., Hurst, L.D. and Izsvák, Z.
Molecular Biology and Evolution 39
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October 2022
Molecular Cell
Healing the wounds inflicted by Sleeping Beauty transposition by double-strand break repair in mammalian somatic cells.
Izsvak, Z., Stuewe, E.E., Fiedler, D., Katzer, A., Jeggo, P.A. and Ivics, Z.
Molecular Cell 13
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1 January 2004
Molecular Marine Biology and Biotechnology
Enhanced incorporation of transgenic DNA into zebrafish chromosomes by a retroviral integration protein.
Ivics, Z., Izsvak, Z. and Hackett, P.B.
Molecular Marine Biology and Biotechnology 2
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June 1993
Molecular Phylogenetics and Evolution
Transposition of the bamboo Mariner-like element Ppmar1 in yeast.
Zhou, M.B., Hu, H., Miskey, C., Lazarow, K., Ivics, Z., Kunze, R., Yang, G., Izsvák, Z. and Tang, D.Q.
Molecular Phylogenetics and Evolution 109
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April 2017
Molecular Therapy
Targeting CD33 in chemoresistant AML patient-derived xenografts by CAR-CIK cells modified with an improved SB transposon system.
Rotiroti, M.C., Buracchi, C., Arcangeli, S., Galimberti, S., Valsecchi, M.G., Perriello, V.M., Rasko, T., Alberti, G., Magnani, C.F., Cappuzzello, C., Lundberg, F., Pande, A., Dastoli, G., Introna, M., Serafini, M., Biagi, E., Izsvák, Z., Biondi, A. and Tettamanti, S.
Molecular Therapy 28
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2 September 2020
Efficient non-viral gene delivery into human hematopoietic stem cells by minicircle Sleeping Beauty transposon vectors.
Holstein, M., Mesa-Nuñez, C., Miskey, C., Almarza, E., Poletti, V., Schmeer, M., Grueso, E., Ordóñez Flores, J.C., Kobelt, D., Walther, W., Aneja, M.K., Geiger, J,, Bonig, H.B., Izsvák, Z., Schleef, M., Rudolph, C., Mavilio, F., Bueren, J.A., Guenechea, G. and Ivics, Z.
Molecular Therapy 26
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4 April 2018
Structural determinants of sleeping beauty transposase activity.
Abrusán, G., Yant, S.R., Szilágyi, A., Marsh, J.A., Mátés, L., Izsvák, Z., Barabás, O. and Ivics, Z.
Molecular Therapy 24
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August 2016
Genome-wide profiling reveals remarkable parallels between insertion site selection properties of the MLV retrovirus and the piggyBac transposon in primary human CD4(+) T cells.
Gogol-Döring, A., Ammar, I., Gupta, S., Bunse, M., Miskey, C., Chen, W., Uckert, W., Schulz, T.F., Izsvák, Z. and Ivics, Z.
Molecular Therapy 24
(3): 592-606.
March 2016
Sleeping Beauty transposon vectors in liver directed gene delivery of LDLR and VLDLR for gene therapy of familial hypercholesterolemia.
Turunen, T.A.K., Kurkipuro, J., Heikura, T., Vuorio, T., Hytönen, E., Izsvák, Z. and Ylä-Herttuala, S.
Molecular Therapy 24
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March 2016
Retargeting Sleeping Beauty transposon insertions by engineered zinc finger DNA-binding domains.
Voigt, K., Gogol-Doering, A., Miskey, C., Chen, W., Cathomen, T., Izsvak, Z. and Ivics, Z.
Molecular Therapy 20
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October 2012
Comparative genomic integration profiling of Sleeping Beauty transposons mobilized with high efficacy from integrase-defective lentiviral vectors in primary human cells.
Moldt, B., Miskey, C., Staunstrup, N.H., Gogol-Doering, A., Bak, R.O., Sharma, N., Mates, L., Izsvak, Z., Chen, W., Ivics, Z. and Mikkelsen, J.G.
Molecular Therapy 19
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August 2011
Comparative analysis of transposable element vector systems in human cells.
Grabundzija, I., Irgang, M., Mates, L., Belay, E., Matrai, J., Gogol-Doering, A., Kawakami, K., Chen, W., Ruiz, P., Chuah, M.K., Vandendriessche, T., Izsvak, Z. and Ivics, Z.
Molecular Therapy 18
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June 2010
Hybrid lentivirus-transposon vectors with a random integration profile in human cells.
Staunstrup, N.H., Moldt, B., Mates, L., Villesen, P., Jakobsen, M., Ivics, Z., Izsvak, Z. and Mikkelsen, J.G.
Molecular Therapy 17
(7): 1205-1214.
July 2009
Transcriptional activities of the Sleeping Beauty transposon and shielding its genetic cargo with insulators.
Walisko, O., Schorn, A., Rolfs, F., Devaraj, A., Miskey, C., Izsvak, Z. and Ivics, Z.
Molecular Therapy 16
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February 2008
Targeted Sleeping Beauty transposition in human cells.
Ivics, Z., Katzer, A., Stuewe, E.E., Fiedler, D., Knespel, S. and Izsvak, Z.
Molecular Therapy 15
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June 2007
Development of hyperactive Sleeping Beauty transposon vectors by mutational analysis.
Zayed, H., Izsvak, Z., Walisko, O. and Ivics, Z.
Molecular Therapy 9
(2): 292-304.
1 February 2004
Sleeping Beauty transposition: biology and applications for molecular therapy.
Izsvak, Z. and Ivics, Z.
Molecular Therapy 9
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1 February 2004
Molecular Therapy - Methods and Clinical Development
Safe and efficient in vivo hematopoietic stem cell transduction in nonhuman primates using HDAd5/35++ vectors.
Li, C., Wang, H., Gil, S., Germond, A., Fountain, C., Baldessari, A., Kim, J., Liu, Z., Georgakopoulou, A., Radtke, S., Raskó, T., Pande, A., Chiang, C., Chin, E., Yannaki, E., Izsvak, Z., Papayannopoulou, T., Kiem, H.P. and Lieber, A.
Molecular Therapy - Methods and Clinical Development 24
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10 March 2022
Preclinical evaluation of a cell-based gene therapy using the Sleeping Beauty transposon system in choroidal neovascularization.
Hernandez, M., Recalde, S., Garcia-Garcia, L., Bezunartea, J., Miskey, C., Johnen, S., Diarra, S., Sebe, A., Rodriguez-Madoz, J.R., Pouillot, S., Marie, C., Izsvák, Z., Scherman, D., Kropp, M., Prosper, F., Thumann, G., Ivics, Z., Garcia-Layana, A. and Fernandez-Robredo, P.
Molecular Therapy - Methods and Clinical Development 15
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13 December 2019
Integrating HDAd5/35++ vectors as a new platform for HSC gene therapy of hemoglobinopathies.
Li, C., Psatha, N., Wang, H., Singh, M., Samal, H.B., Zhang, W., Ehrhardt, A., Izsvák, Z., Papayannopoulou, T. and Lieber, A.
Molecular Therapy - Methods and Clinical Development 9
: 142-152.
15 June 2018
A combined in vivo HSC transduction/selection approach results in efficient and stable gene expression in peripheral blood cells in mice.
Wang, H., Richter, M., Psatha, N., Li, C., Kim, J., Liu, J., Ehrhardt, A., Nilsson, S.K., Cao, B., Palmer, D., Ng, P., Izsvák, Z., Haworth, K.G., Kiem, H.P., Papayannopoulou, T. and Lieber, A.
Molecular Therapy - Methods and Clinical Development 8
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16 March 2018
Molecular Therapy - Nucleic Acids
The antibiotic-free pFAR4 vector paired with the sleeping beauty transposon sSystem mediates efficient transgene delivery in human cells.
Pastor, M., Johnen, S., Harmening, N., Quiviger, M., Pailloux, J., Kropp, M., Walter, P., Ivics, Z., Izsvák, Z., Thumann, G., Scherman, D. and Marie, C.
Molecular Therapy - Nucleic Acids 11
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1 June 2018
Long-term PEDF release in rat iris and retinal epithelial cells after Sleeping Beauty transposon-mediated gene delivery.
Garcia-Garcia, L., Recalde, S., Hernandez, M., Bezunartea, J., Rodriguez-Madoz, J.R., Johnen, S., Diarra, S., Marie, C., Izsvák, Z., Ivics, Z., Scherman, D., Kropp, M., Thumann, G., Prosper, F., Fernandez-Robredo, P. and Garcia-Layana, A.
Molecular Therapy - Nucleic Acids 9
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15 December 2017
Engineering of PEDF-expressing primary pigment epithelial cells by the SB transposon system delivered by pFAR4 plasmids.
Thumann, G., Harmening, N., Prat-Souteyrand, C., Marie, C., Pastor, M., Sebe, A., Miskey, C., Hurst, L., Diarra, S., Kropp, M., Walter, P., Scherman, D., Ivics, Z., Izsvák, Z. and Johnen, S.
Molecular Therapy - Nucleic Acids 6
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17 March 2017
Full-length dysferlin transfer by the hyperactive Sleeping Beauty transposase restores dysferlin-deficient muscle.
Escobar, H., Schöwel, V., Spuler, S., Marg, A. and Izsvák, Z.
Molecular Therapy - Nucleic Acids 5
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19 January 2016
Molecular and Cellular Biology
The Ancient Mariner Sails Again: Transposition of the Human Hsmar1 Element by a Reconstructed Transposase and Activities of the SETMAR Protein on Transposon Ends.
Miskey, C., Papp, B., Mates, L., Sinzelle, L., Keller, H., Izsvak, Z. and Ivics, Z.
Molecular and Cellular Biology 27
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15 June 2007
Molecular and General Genetics
Characterization of a Tc1-like transposable element in zebrafish (Danio rerio).
Izsvak, Z., Ivics, Z. and Hackett, P.B.
Molecular and General Genetics 247
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10 May 1995
Nature
Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells.
Wang, J., Xie, G., Singh, M., Ghanbarian, A.T., Raskó, T., Szvetnik, A., Cai, H., Besser, D., Prigione, A., Fuchs, N.V., Schumann, G.G., Chen, W., Lorincz, M.C., Ivics, Z., Hurst, L.D. and Izsvák, Z.
Nature 516
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18 December 2014
Gibbon genome and the fast karyotype evolution of small apes.
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Nature 513
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11 September 2014
Hungary's 'reforms' are threatening basic science.
Izsvak, Z., Ivics, Z. and Mates, L.
Nature 443
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28 September 2006
Nature Biomedical Engineering
Non-viral targeted insertion of large payloads into T cells.
Izsvak, Z.
Nature Biomedical Engineering
16 September 2024
(In Press)
Nature Communications
Sleeping Beauty transposase structure allows rational design of hyperactive variants for genetic engineering.
Voigt, F., Wiedemann, L., Zuliani, C., Querques, I., Sebe, A., Mátés, L., Izsvák, Z., Ivics, Z. and Barabas, O.
Nature Communications 7
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30 March 2016
A Helitron transposon reconstructed from bats reveals a novel mechanism of genome shuffling in eukaryotes.
Grabundzija, I., Messing, S.A., Thomas, J., Cosby, R.L., Bilic, I., Miskey, C., Gogol-Döring, A., Kapitonov, V., Diem, T., Dalda, A., Jurka, J., Pritham, E.J., Dyda, F., Izsvák, Z. and Ivics, Z.
Nature Communications 7
: 10716.
2 March 2016
Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells.
Klawitter, S., Fuchs, N.V., Upton, K.R., Muñoz-Lopez, M., Shukla, R., Wang, J., Garcia-Cañadas, M., Lopez-Ruiz, C., Gerhardt, D.J., Sebe, A., Grabundzija, I., Merkert, S., Gerdes, P., Pulgarin, J.A., Bock, A., Held, U., Witthuhn, A., Haase, A., Sarkadi, B., Löwer, J., Wolvetang, E.J., Martin, U., Ivics, Z., Izsvák, Z., Garcia-Perez, J.L., Faulkner, G.J. and Schumann, G.G.
Nature Communications 7
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8 January 2016
Nature Genetics
Human somatic cell mutagenesis creates genetically tractable sarcomas.
Molyneux, S.D., Waterhouse, P.D., Shelton, D., Shao, Y.W., Watling, C.M., Tang, Q.L., Harris, I.S., Dickson, B.C., Tharmapalan, P., Sandve, G.K., Zhang, X., Bailey, S.D., Berman, H., Wunder, J.S., Izsvák, Z., Lupien, M., Mak, T.W. and Khokha, R.
Nature Genetics 46
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September 2014
Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates.
Mates, L., Chuah, M.K., Belay, E., Jerchow, B., Manoj, N., Acosta-Sanchez, A., Grzela, D.P., Schmitt, A., Becker, K., Matrai, J., Ma, L., Samara-Kuko, E., Gysemans, C., Pryputniewicz, D., Miskey, C., Fletcher, B., Vandendriessche, T., Ivics, Z. and Izsvak, Z.
Nature Genetics 41
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June 2009
Progress and prospects in rat genetics: a community view.
Aitman, T.J., Critser, J.K., Cuppen, E., Dominiczak, A., Fernandez-Suarez, X.M., Flint, J., Gauguier, D., Geurts, A.M., Gould, M., Harris, P.C., Holmdahl, R., Huebner, N., Izsvak, Z., Jacob, H.J., Kuramoto, T., Kwitek, A.E., Marrone, A., Mashimo, T., Moreno, C., Mullins, J., Mullins, L., Olsson, T., Pravenec, M., Riley, L., Saar, K., Serikawa, T., Shull, J.D., Szpirer, C., Twigger, S.N., Voigt, B. and Worley, K.C.
Nature Genetics 40
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May 2008
Somatic integration and long-term transgene expression in normal and haemophilic mice using a DNA transposon system.
Yant, S.R., Meuse, L., Chiu, W., Ivics, Z., Izsvak, Z. and Kay, M.A.
Nature Genetics 25
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1 May 2000
Nature Methods
Generating knockout rats by transposon mutagenesis in spermatogonial stem cells.
Izsvak, Z., Froehlich, J., Grabundzija, I., Shirley, J.R., Powell, H.M., Chapman, K.M., Ivics, Z. and Hamra, F.K.
Nature Methods 7
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June 2010
Transposon-mediated genome manipulation in vertebrates.
Ivics, Z., Li, M.A., Mates, L., Boeke, J.D., Nagy, A., Bradley, A. and Izsvak, Z.
Nature Methods 6
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June 2009
Sleeping Beauty hits them all: transposon-mediated saturation mutagenesis in the mouse germline.
Izsvak, Z. and Ivics, Z.
Nature Methods 2
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October 2005
Nature Protocols
Isolation and cultivation of naive-like human pluripotent stem cells based on HERVH expression.
Wang, J., Singh, M., Sun, C., Besser, D., Prigione, A., Ivics, Z., Hurst, L.D. and Izsvák, Z.
Nature Protocols 11
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February 2016
Germline transgenesis in pigs by cytoplasmic microinjection of Sleeping Beauty transposons.
Ivics, Z., Garrels, W., Mátés, L., Yau, T.Y., Bashir, S., Zidek, V., Landa, V., Geurts, A., Pravenec, M., Rülicke, T., Kues, W.A. and Izsvák, Z.
Nature Protocols 9
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April 2014
Germline transgenesis in rabbits by pronuclear microinjection of Sleeping Beauty transposons.
Ivics, Z., Hiripi, L., Hoffmann, O.I., Mátés, L., Yau, T.Y., Bashir, S., Zidek, V., Landa, V., Geurts, A., Pravenec, M., Rülicke, T., Bösze, Z. and Izsvák, Z.
Nature Protocols 9
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April 2014
Germline transgenesis in rodents by pronuclear microinjection of Sleeping Beauty transposons.
Ivics, Z., Mátés, L., Yau, T.Y., Landa, V., Zidek, V., Bashir, S., Hoffmann, O.I., Hiripi, L., Garrels, W., Kues, W.A., Boesze, Z., Geurts, A., Pravenec, M., Rülicke, T. and Izsvák, Z.
Nature Protocols 9
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April 2014
Sleeping Beauty transposon mutagenesis in rat spermatogonial stem cells.
Ivics, Z., Izsvak, Z., Medrano, G., Chapman, K.M. and Hamra, F.K.
Nature Protocols 6
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October 2011
Nature Reviews Genetics
Selection on synonymous sites: the unwanted transcript hypothesis.
Radrizzani, S., Kudla, G., Izsvák, Z. and Hurst, L.D.
Nature Reviews Genetics 25
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June 2024
Nucleic Acids Research
A single amino acid switch converts the sleeping beauty transposase into an efficient unidirectional excisionase with utility in stem cell reprogramming.
Kesselring, L., Miskey, C., Zuliani, C., Querques, I., Kapitonov, V., Laukó, A., Fehér, A., Palazzo, A., Diem, T., Lustig, J., Sebe, A., Wang, Y., Dinnyés, A., Izsvák, Z., Barabas, O. and Ivics, Z.
Nucleic Acids Research 48
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Regulated complex assembly safeguards the fidelity of Sleeping Beauty transposition.
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Sleeping Beauty transposon-based system for cellular reprogramming and targeted gene insertion in induced pluripotent stem cells.
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Nucleic Acids Research 41
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Retargeting transposon insertions by the adeno-associated virus Rep protein.
Ammar, I., Gogol-Doering, A., Miskey, C., Chen, W., Cathomen, T., Izsvak, Z. and Ivics, Z.
Nucleic Acids Research 40
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1 August 2012
Avoiding cytotoxicity of transposases by dose-controlled mRNA delivery.
Galla, M., Schambach, A., Falk, C.S., Maetzig, T., Kuehle, J., Lange, K., Zychlinski, D., Heinz, N., Brugman, M.H., Goehring, G., Izsvak, Z., Ivics, Z. and Baum, C.
Nucleic Acids Research 39
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1 September 2011
Efficient conditional and promoter-specific in vivo expression of cDNAs of choice by taking advantage of recombinase-mediated cassette exchange using FlEx gene traps.
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May 2010
The Frog Prince: a reconstructed transposon from Rana pipiens with high transpositional activity in vertebrate cells.
Miskey, C., Izsvak, Z., Plasterk, R.H. and Ivics, Z.
Nucleic Acids Research 31
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1 December 2003
The DNA-bending protein HMGB1 is a cellular cofactor of Sleeping Beauty transposition.
Zayed, H., Izsvak, Z., Khare, D., Heinemann, U. and Ivics, Z.
Nucleic Acids Research 31
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1 May 2003
PLoS Biology
A new human embryonic cell type associated with activity of young transposable elements allows definition of the inner cell mass.
Singh, M., Kondrashkina, A., Widmann, T.J., Cortes, J.L., Bansal, V., Wang, J., Römer, C., Garcia-Canadas, M., Garcia-Perez, J.L., Hurst, L.D. and Izsvak, Z.
PLoS Biology 21
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20 June 2023
PLoS Genetics
Suicidal autointegration of Sleeping Beauty and piggyBac transposons in eukaryotic cells.
Wang, Y., Wang, J., Devaraj, A., Singh, M., Jimenez Orgaz, A., Chen, J.X., Selbach, M., Ivics, Z. and Izsvák, Z.
PLoS Genetics 10
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13 March 2014
PLoS ONE
A simple approach for multi-targeted shRNA-mediated inducible knockdowns using Sleeping Beauty vectors.
Fink, S., Zugelder, L., Roth, B., Brandt, E., Meloche, S., Izsvák, Z., Bargou, R.C. and Stühmer, T.
PLoS ONE 13
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19 October 2018
Generation of an immortalized mesenchymal stem cell line producing a secreted biosensor protein for glucose monitoring.
Siska, E.K., Weisman, I., Romano, J., Ivics, Z., Izsvák, Z., Barkai, U., Petrakis, S. and Koliakos, G.
PLoS ONE 12
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26 September 2017
Targeting of the Plzf gene in the rat by transcription activator-like effector nuclease results in caudal regression syndrome in spontaneously hypertensive rats.
Liška, F., Peterková, R., Peterka, M., Landa, V., Zidek, V., Mlejnek, P., Šilhavý, J., Šimáková, M., Křen, V., Starker, C.G., Voytas, D.F., Izsvák, Z. and Pravenec, M.
PLoS ONE 11
(10): e0164206.
11 October 2016
Genomic analysis of Sleeping Beauty transposon integration in human somatic cells.
Turchiano, G., Latella, M.C., Gogol-Döring, A., Cattoglio, C., Mavilio, F., Izsvák, Z., Ivics, Z. and Recchia, A.
PLoS ONE 9
(11): e112712.
12 November 2014
Hybrid adeno-associated viral vectors utilizing transposase-mediated somatic integration for stable transgene expression in human cells.
Zhang, W., Solanki, M., Müther, N., Ebel, M., Wang, J., Sun, C., Izsvak, Z. and Ehrhardt, A.
PLoS ONE 8
(10): e76771.
8 October 2013
Integration profile and safety of an adenovirus hybrid-vector utilizing hyperactive Sleeping Beauty transposase for somatic integration.
Zhang, W., Muck-Hausl, M., Wang, J., Sun, C., Gebbing, M., Miskey, C., Ivics, Z., Izsvak, Z. and Ehrhardt, A.
PLoS ONE 8
(10): e75344.
4 October 2013
Genotype-independent transmission of transgenic fluorophore protein by boar spermatozoa.
Garrels, W., Holler, S., Taylor, U., Herrmann, D., Struckmann, C., Klein, S., Barg-Kues, B., Nowak-Imialek, M., Ehling, C., Rath, D., Ivics, Z., Niemann, H. and Kues, W.A.
PLoS ONE 6
(11): e27563.
16 November 2011
Germline transgenic pigs by Sleeping Beauty transposition in porcine zygotes and targeted integration in the pig genome.
Garrels, W., Mates, L., Holler, S., Dalda, A., Taylor, U., Petersen, B., Niemann, H., Izsvak, Z., Ivics, Z. and Kues, W.A.
PLoS ONE 6
(8): e23573.
29 August 2011
Pathologie Biologie
Elements transposables: des outils permettant la mutagenese et le transgenese chez les vertebres [Transposable elements as tools from mutagenesis and transgenesis of vertebrates].
Plasterk, R.H., Van Luenen, H., Vos, C., Ivics, Z., Izsvak, Z. and Fischer, S.
Pathologie Biologie 46
: 674-675.
1 November 1998
Proceedings of the National Academy of Sciences of the United States of America
Transposition of a reconstructed Harbinger element in human cells and functional homology with two transposon-derived cellular genes.
Sinzelle, L., Kapitonov, V.V., Grzela, D.P., Jursch, T., Jurka, J., Izsvak, Z. and Ivics, Z.
Proceedings of the National Academy of Sciences of the United States of America 105
(12): 4715-4720.
25 March 2008
Sleeping Beauty transposase modulates cell-cycle progression through interaction with Miz-1.
Walisko, O., Izsvak, Z., Szabo, K., Kaufman, C.D., Herold, S. and Ivics, Z.
Proceedings of the National Academy of Sciences of the United States of America 103
(11): 4062-4067.
14 March 2006
Chromosomal transposition of a Tc1/mariner-like element in mouse embryonic stem cells.
Luo, G., Ivics, Z., Izsvak, Z. and Bradley, A.
Proceedings of the National Academy of Sciences of the United States of America 95
(18): 10769-10773.
1 September 1998
Identification of functional domains and evolution of Tc1-like transposable elements.
Ivics, Z., Izsvak, Z., Minter, A. and Hackett, P.B.
Proceedings of the National Academy of Sciences of the United States of America 93
(10): 5008-5013.
14 May 1996
DANA elements: a family of composite, tRNA-derived short interspersed DNA elements associated with mutational activities in zebrafish (Danio rerio).
Izsvak, Z., Ivics, Z., Garcia-Estefania, D., Fahrenkrug, S.C. and Hackett, P.B.
Proceedings of the National Academy of Sciences of the United States of America 93
(3): 1077-1081.
6 February 1996
Redox Biology
Nuclear inclusions of pathogenic ataxin-1 induce oxidative stress and perturb the protein synthesis machinery.
Laidou, S., Alanis-Lobato, G., Pribyl, J., Raskó, T., Tichy, B., Mikulasek, K., Tsagiopoulou, M., Oppelt, J., Kastrinaki, G., Lefaki, M., Singh, M., Zink, A., Chondrogianni, N., Psomopoulos, F., Prigione, A., Ivics, Z., Pospisilova, S., Skladal, P., Izsvák, Z., Andrade-Navarro, M.A. and Petrakis, S.
Redox Biology 32
: 101458.
May 2020
Retrovirology
Human endogenous retrovirus K (HML-2) RNA and protein expression is a marker for human embryonic and induced pluripotent stem cells.
Fuchs, N.V., Loewer, S., Daley, G.Q., Izsvák, Z., Löwer, J. and Löwer, R.
Retrovirology 10
(1): 115.
24 October 2013
Scientific Reports
Naïve-like pluripotency to pave the way for saving the northern white rhinoceros from extinction.
Zywitza, V., Rusha, E., Shaposhnikov, D., Ruiz-Orera, J., Telugu, N., Rishko, V., Hayashi, M., Michel, G., Wittler, L., Stejskal, J., Holtze, S., Göritz, F., Hermes, R., Wang, J., Izsvák, Z., Colleoni, S., Lazzari, G., Galli, C., Hildebrandt, T.B., Hayashi, K., Diecke, S. and Drukker, M.
Scientific Reports 12
(1): 3100.
8 March 2022
Seminars in Cancer Biology
Repetitive elements and genome instability.
Ivics, Z. and Izsvak, Z.
Seminars in Cancer Biology 20
(4): 197-199.
August 2010
Stem Cell Research
Generation of human induced pluripotent stem cell line from a patient with a long QT syndrome type 2.
Fatima, A., Ivanyuk, D., Herms, S., Heilmann-Heimbach, S., O'Shea, O., Chapman, C., Izsvák, Z., Farr, M., Hescheler, J. and Šarić, T.
Stem Cell Research 16
(2): 304-307.
March 2016
Stem Cells
Impaired cell reprogramming in non-homologous end joining deficient cells.
Molina-Estevez, F.J., Lozano, M.L., Navarro, S., Torres, Y., Grabundzija, I., Ivics, Z., Samper, E., Bueren, J.A. and Guenechea, G.
Stem Cells 31
(8): 1726-1730.
August 2013
Novel hyperactive transposons for genetic modification of induced puripotent and adult stem cells: a non-viral paradigm for coaxed differentiation.
Belay, E., Matrai, J., Acosta-Sanchez, A., Ma, L., Quattrocelli, M., Mates, L., Sancho-Bru, P., Geraerts, M., Yan, B., Vermeesch, J., Rincon, M.Y., Samara-Kuko, E., Ivics, Z., Verfaillie, C.M., Sampaolesi, M., Izsvak, Z., Vandendriessche, T. and Chuah, M.K.
Stem Cells 28
(10): 1760-1771.
October 2010
Applying a "double-feature" promoter to identify cardiomyocytes differentiated from human embryonic stem cells following transposon-based gene delivery.
Orban, T.I., Apati, A., Nemeth, A., Varga, N., Krizsik, V., Schamberger, A., Szebenyi, K., Erdei, Z., Varady, G., Karaszi, E., Homolya, L., Nemet, K., Gocza, E., Miskey, C., Mates, L., Ivics, Z., Izsvak, Z. and Sarkadi, B.
Stem Cells 27
(5): 1077-1087.
20 February 2009
Stem Cells and Development
Derivation and characterization of Sleeping Beauty transposon-mediated porcine induced pluripotent stem cells.
Kues, W.A., Herrmann, D., Barg-Kues, B., Meena Haridoss, S., Nowak-Imialek, M., Buchholz, T., Streeck, M., Grebe, A., Grabundzija, I., Merkert, S., Martin, U., Hall, V.J., Rasmussen, M.A., Ivics, Z., Maddox-Hyttel, P. and Niemann, H.
Stem Cells and Development 22
(1): 124-135.
1 January 2013
Transgenic Research
Identification and re-addressing of a transcriptionally permissive locus in the porcine genome.
Garrels, W., Mukherjee, A., Holler, S., Cleve, N., Talluri, T.R., Barg-Kues, B., Diederich, M., Köhler, P., Petersen, B., Lucas-Hahn, A., Niemann, H., Izsvák, Z., Ivics, Z. and Kues, W.A.
Transgenic Research 25
(1): 63-70.
February 2016
Trends in Genetics
Gene therapy with the Sleeping Beauty transposon system.
Kebriaei, P., Izsvák, Z., Narayanavari, S.A., Singh, H. and Ivics, Z.
Trends in Genetics 33
(11): 852-870.
November 2017
A whole lotta jumpin' goin' on: new transposon tools for vertebrate functional genomics.
Ivics, Z. and Izsvak, Z.
Trends in Genetics 21
(1): 8-11.
1 January 2005
Resident aliens: the Tc1/mariner superfamily of transposable elements.
Plasterk, R.H., Izsvak, Z. and Ivics, Z.
Trends in Genetics 15
: 326-332.
1 August 1999
Viruses
Human endogenous retrovirus K rec forms a regulatory loop with MITF that opposes the progression of melanoma to an invasive stage.
Singh, M., Cai, H., Bunse, M., Feschotte, C. and Izsvák, Z.
Viruses 12
(11): 1303.
13 November 2020
Zeitschrift fuer Naturforschung C, A Journal of Biosciences
Purification and characterization of CeqI restriction endonuclease.
Izsvak, Z., Jobbagy, Z. and Duda, E.
Zeitschrift fuer Naturforschung C, A Journal of Biosciences 47
: 830-834.
1 November 1992
Zuechtungskunde
Transgene Expression durch zytoplasmatische Injektion von Plasmiden und Transposon-basierten Konstrukten in Saeugerembryonen [Transgenetic expression by cytoplasmic injection of plasmids and transposon-based constructs in mammalian embryos].
Garrels, W., Holler, S., Ivics, Z., Niemann, H. and Kues, W.A.
Zuechtungskunde 83
(1): 47-67.
January 2011
bioRxiv
HMGXB4 targets Sleeping Beauty transposition to vertebrate germinal stem sells.
Devaraj, A., Singh, M., Narayanavari, S., Yong, G., Wang, J., Wang, J., Becker, M., Walisko, O., Schorn, A., Cseresznyés, Z., Grzela, D., Raskó, T., Selbach, M., Ivics, Z. and Izsvák, Z.
bioRxiv
: 2020.06.15.145656.
15 June 2020
Mutant screen reveals the Piccolo's control over depression and brain-gonad crosstalk.
Medrano, G.A., Singh, M., Plautz, E.J., Good, L.B., Chapman, K.M., Chaudhary, J., Jaichander, P., Powell, H.M., Pudasaini, A., Shelton, J.M., Richardson, J.A., Xie, X.J., Ivics, Z., Braun, C., Ackermann, F., Garner, C.C., Izsvak, Z. and Hamra, F.K.
bioRxiv
: 405985.
31 August 2018
The phylogenetically distinct early human embryo.
Singh, M., Widmann, T.J., Cortes, J.L., Schumann, G.G., Wunderlich, S., Martin, U., Garcia-Perez, J.L., Hurst, L.D. and Izsvak, Z.
bioRxiv
: 318329.
18 May 2018
eLife
Critical role for piccolo in synaptic vesicle retrieval.
Ackermann, F., Schink, K.O., Bruns, C., Izsvák, Z., Hamra, F.K., Rosenmund, C. and Garner, C.C.
eLife 8
: e46629.
10 May 2019
iScience
Atypical KCNQ1/Kv7 channel function in a neonatal diabetes patient: hypersecretion preceded the failure of pancreatic β-cells.
Zhou, Z., Gong, M., Pande, A., Margineanu, A., Lisewski, U., Purfürst, B., Zhu, H., Liang, L., Jia, S., Froehler, S., Zeng, C., Kühnen, P., Khodaverdi, S., Krill, W., Röpke, T., Chen, W., Raile, K., Sander, M. and Izsvák, Z.
iScience 27
(7): 110291.
19 July 2024
This list was generated on Mon Oct 7 10:26:46 2024 UTC.