Browse by Research Team

American Journal of Human Genetics

The genetic ancestry of modern Indus Valley populations from Northwest India.
Pathak, A.K. and Kadian, A. and Kushniarevich, A. and Montinaro, F. and Mondal, M. and Ongaro, L. and Singh, M. and Kumar, P. and Rai, N. and Parik, J. and Metspalu, E. and Rootsi, S. and Pagani, L. and Kivisild, T. and Metspalu, M. and Chaubey, G. and Villems, R.
American Journal of Human Genetics 103 (6): 918-929. 6 December 2018

Annals of Translational Medicine

Localized irradiation of mouse legs using an image-guided robotic linear accelerator.
Kufeld, M. and Escobar, H. and Marg, A. and Pasemann, D. and Budach, V. and Spuler, S.
Annals of Translational Medicine 5 (7): 156. April 2017

Arteriosclerosis Thrombosis and Vascular Biology

Long-term prevention of congenital thrombotic thrombocytopenic purpura in ADAMTS13 knockout mice by sleeping beauty transposon-mediated gene therapy.
Verhenne, S. and Vandeputte, N. and Pareyn, I. and Izsvák, Z. and Rottensteiner, H. and Deckmyn, H. and De Meyer, S.F. and Vanhoorelbeke, K.
Arteriosclerosis Thrombosis and Vascular Biology 37 (5): 836-844. May 2017

BMC Biotechnology

Novel strong tissue specific promoter for gene expression in human germ cells.
Kuzmin, D. and Gogvadze, E. and Kholodenko, R. and Grzela, D.P. and Mityaev, M. and Vinogradova, T. and Kopantzev, E. and Malakhova, G. and Suntsova, M. and Sokov, D. and Ivics, Z. and Buzdin, A.
BMC Biotechnology 10 (1): 58. 17 August 2010

BioEssays

Pluripotency and the endogenous retrovirus HERVH: Conflict or serendipity?
Izsvák, Z. and Wang, J. and Singh, M. and Mager, D.L. and Hurst, L.D.
BioEssays 38 (1): 109-117. January 2016

Translating Sleeping Beauty transposition into cellular therapies: Victories and challenges.
Izsvak, Z. and Hackett, P.B. and Cooper, L.J. and Ivics, Z.
BioEssays 32 (9): 756-767. September 2010

BioMed Research International

Antiangiogenic and neurogenic activities of Sleeping Beauty-mediated PEDF-transfected RPE cells in vitro and in vivo.
Johnen, S. and Djalali-Talab, Y. and Kazanskaya, O. and Möller, T. and Harmening, N. and Kropp, M. and Izsvák, Z. and Walter, P. and Thumann, G.
BioMed Research International 2015 : 863845. 2015

Biochemical Journal

Positive co-operative interaction between the subunits of CeqI restriction endonuclease.
Jobbagy, Z. and Izsvak, Z. and Duda, E.
Biochemical Journal 286 : 85-88. 15 August 1992

‘Star’ activity and complete loss of specificity of CeqI endonuclease.
Izsvak, Z. and Duda, E.
Biochemical Journal 258 (1): 301-303. February 1989

Biochemistry and Cell Biology

Repetitive elements and their genetic applications in zebrafish.
Izsvak, Z. and Ivics, Z. and Hackett, P.B.
Biochemistry and Cell Biology 75 (5): 507-523. 1 October 1997

Biomedicines

GMP-grade manufacturing and quality control of a non-virally engineered advanced therapy medicinal product for personalized treatment of age-related macular degeneration.
Kropp, M. and Harmening, N. and Bascuas, T. and Johnen, S. and De Clerck, E. and Fernández, V. and Ronchetti, M. and Cadossi, R. and Zanini, C. and Scherman, D. and Ivics, Z. and Marie, C. and Izsvák, Z. and Thumann, G.
Biomedicines 10 (11): 2777. November 2022

Biomolecules

Enhanced biosafety of the Sleeping Beauty transposon system by using mRNA as source of transposase to efficiently and stably transfect retinal pigment epithelial cells.
Harmening, N. and Johnen, S. and Izsvák, Z. and Ivics, Z. and Kropp, M. and Bascuas, T. and Walter, P. and Kreis, A. and Pajic, B. and Thumann, G.
Biomolecules 13 (4): 658. 7 April 2023

Biotechniques

Family of plasmid vectors for the expression of beta-galactosidase fusion proteins in eukaryotic cells.
Ivics, Z. and Izsvak, Z.
Biotechniques 22 : 254-258. 1 February 1997

Two-stage ligation-mediated PCR enhances the detection of integrated transgenic DNA.
Izsvak, Z. and Ivics, Z.
Biotechniques 15, 5 : 814-818. 1 November 1993

Biotechnology Journal

Gateway compatible transposon vector to genetically modify human embryonic kidney and adipose-derived stromal cells.
Petrakis, S. and Rasko, T. and Mates, L. and Ivics, Z. and Izsvak, Z. and Kouzi-Koliakou, K. and Koliakos, G.
Biotechnology Journal 7 (7): 891-897. July 2012

Blood

In vivo transduction of primitive mobilized hematopoietic stem cells after intravenous injection of integrating adenovirus vectors.
Richter, M. and Saydaminova, K. and Yumul, R. and Krishnan, R. and Liu, J. and Nagy, E.E. and Singh, M. and Izsvák, Z. and Cattaneo, R. and Uckert, W. and Palmer, D. and Ng, P. and Haworth, K.G. and Kiem, H.P. and Ehrhardt, A. and Papayannopoulou, T. and Lieber, A.
Blood 128 (18): 2206-2217. 3 November 2016

Emerging potential of transposons for gene therapy and generation of induced pluripotent stem cells.
Vandendriessche, T. and Ivics, Z. and Izsvak, Z. and Chuah, M.K.
Blood 114 (8): 1461-1468. 20 August 2009

Stable gene transfer and expression in cord blood-derived CD34+ hematopoietic stem and progenitor cells by a hyperactive Sleeping Beauty transposon system.
Xue, X. and Huang, X. and Nodland, S.E. and Mates, L. and Ma, L. and Izsvak, Z. and Ivics, Z. and Lebien, T.W. and McIvor, R.S. and Wagner, J.E. and Zhou, X.
Blood 114 (7): 1319-1330. 13 August 2009

Blood Advances

Single-dose MGTA-145/plerixafor leads to efficient mobilization and in vivo transduction of HSCs with thalassemia correction in mice.
Li, C. and Goncalves, K.A. and Raskó, T. and Pande, A. and Gil, S. and Liu, Z. and Izsvák, Z. and Papayannopoulou, T. and Davis, J.C. and Kiem, H.P. and Lieber, A.
Blood Advances 5 (5): 1239-1249. 9 March 2021

Cell

Molecular reconstruction of Sleeping Beauty, a Tc1-like transposon from fish, and its transposition in human cells.
Ivics, Z. and Hackett, P.B. and Plasterk, R.H. and Izsvak, Z.
Cell 91 (4): 501-510. 14 November 1997

Cell Reports

Recapitulating early human development with 8C-like cells.
Yu, X. and Liang, S. and Chen, M. and Yu, H. and Li, R. and Qu, Y. and Kong, X. and Guo, R. and Zheng, R. and Izsvak, Z. and Sun, C. and Yang, M. and Wang, J.
Cell Reports 39 (12): 110994. 21 June 2022

Cell Stem Cell

Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells.
Yang, M. and Yu, H. and Yu, X. and Liang, S. and Hu, Y. and Luo, Y. and Izsvák, Z. and Sun, C. and Wang, J.
Cell Stem Cell 29 (3): 400-418.e13. 3 March 2022

Human iPSC-derived neural progenitors are an effective drug discovery model for neurological mtDNA disorders.
Lorenz, C. and Lesimple, P. and Bukowiecki, R. and Zink, A. and Inak, G. and Mlody, B. and Singh, M. and Semtner, M. and Mah, N. and Auré, K. and Leong, M. and Zabiegalov, O. and Lyras, E.M. and Pfiffer, V. and Fauler, B. and Eichhorst, J. and Wiesner, B. and Huebner, N. and Priller, J. and Mielke, T. and Meierhofer, D. and Izsvák, Z. and Meier, J.C. and Bouillaud, F. and Adjaye, J. and Schuelke, M. and Wanker, E.E. and Lombès, A. and Prigione, A.
Cell Stem Cell 20 (5): 659-674.e9. 4 May 2017

Cell and Gene Therapy Insights

Sleeping Beauty transposon vectors for therapeutic applications: advances and challenges.
Narayanavari, S.A. and Izsvák, Z.
Cell and Gene Therapy Insights 3 (2): 131-158. 30 March 2017

Cellular and Molecular Life Sciences

Molecular domestication of transposable elements: From detrimental parasites to useful host genes.
Sinzelle, L. and Izsvak, Z. and Ivics, Z.
Cellular and Molecular Life Sciences 66 (6): 1073-1093. March 2009

DNA transposons in vertebrate functional genomics.
Miskey, C. and Izsvak, Z. and Kawakami, K. and Ivics, Z.
Cellular and Molecular Life Sciences 62 (6): 629-641. March 2005

Circulation

Disturbed placental imprinting in preeclampsia leads to altered expression of DLX5, a human-specific early trophoblast marker.
Zadora, J. and Singh, M. and Herse, F. and Przybyl, L. and Haase, N. and Golic, M. and Yung, H.W. and Huppertz, B. and Cartwright, J.E. and Whitley, G.S. and Johnsen, G.M. and Levi, G. and Isbruch, A. and Schulz, H. and Luft, F.C. and Müller, D.N. and Staff, A.C. and Hurst, L.D. and Dechend, R. and Izsvák, Z.
Circulation 136 (19): 1824-1839. 7 November 2017

Critical Reviews in Biochemistry and Molecular Biology

Going non-viral: the Sleeping Beauty transposon system breaks on through to the clinical side.
Hudecek, M. and Izsvák, Z. and Johnen, S. and Renner, M. and Thumann, G. and Ivics, Z.
Critical Reviews in Biochemistry and Molecular Biology 52 (4): 355-380. August 2017

Sleeping Beauty transposition: from biology to applications.
Narayanavari, S.A. and Chilkunda, S.S. and Ivics, Z. and Izsvák, Z.
Critical Reviews in Biochemistry and Molecular Biology 52 (1): 18-44. January 2017

Current Gene Therapy

Recombinase technology for gene therapy.
Ivics, Z.
Current Gene Therapy 11 (5): 331. 1 October 2011

Transposons for gene therapy!
Ivics, Z. and Izsvak, Z.
Current Gene Therapy 6 (5): 593-607. October 2006

Current Issues in Molecular Biology

The Sleeping Beauty transposable element: evolution, regulation and genetic applications.
Ivics, Z. and Kaufman, C.D. and Zayed, H. and Miskey, C. and Walisko, O. and Izsvak, Z.
Current Issues in Molecular Biology 6 (1): 43-55. 1 January 2004

Current Opinion in Virology

How to tame an endogenous retrovirus: HERVH and the evolution of human pluripotency.
Römer, C. and Singh, M. and Hurst, L.D. and Izsvák, Z.
Current Opinion in Virology 25 : 49-58. August 2017

Developmental Dynamics

Germline transgenesis of the chordate Ciona intestinalis with hyperactive variants of sleeping beauty transposable element.
Hozumi, A. and Mita, K. and Miskey, C. and Mates, L. and Izsvak, Z. and Ivics, Z. and Satake, H. and Sasakura, Y.
Developmental Dynamics 242 (1): 30-43. January 2013

European Journal of Medical Genetics

Improved molecular platform for the gene therapy of rare diseases by liver protein secretion.
Quiviger, M. and Giannakopoulos, A. and Verhenne, S. and Marie, C. and Stavrou, E.F. and Vanhoorelbeke, K. and Izsvák, Z. and De Meyer, S.F. and Athanassiadou, A. and Scherman, D.
European Journal of Medical Genetics 61 (11): 723-728. November 2018

Experimental Cell Research

Generation of mouse induced pluripotent stem cells from different genetic backgrounds using Sleeping beauty transposon mediated gene transfer.
Muenthaisong, S. and Ujhelly, O. and Polgar, Z. and Varga, E. and Ivics, Z. and Pirity, M.K. and Dinnyes, A.
Experimental Cell Research 318 (19): 2482-2489. 15 November 2012

Expert Opinion on Biological Therapy

The Sleeping Beauty transposon system for clinical applications.
Swierczek, M. and Izsvak, Z. and Ivics, Z.
Expert Opinion on Biological Therapy 12 (2): 139-153. February 2012

FASEB Journal

Transposon-mediated transgenesis, transgenic rescue, and tissue-specific gene expression in rodents and rabbits.
Katter, K. and Geurts, A.M. and Hoffmann, O. and Mátés, L. and Landa, V. and Hiripi, L. and Moreno, C. and Lazar, J. and Bashir, S. and Zidek, V. and Popova, E. and Jerchow, B. and Becker, K. and Devaraj, A. and Walter, I. and Grzybowksi, M. and Corbett, M. and Filho, A.R. and Hodges, M.R. and Bader, M. and Ivics, Z. and Jacob, H.J. and Pravenec, M. and Bosze, Z. and Rülicke, T. and Izsvák, Z.
FASEB Journal 27 (3): 930-941. March 2013

Gene

Functional indications for transposase domestications - characterization of the human piggyBac transposase derived (PGBD) activities.
Kolacsek, O. and Wachtl, G. and Fóthi, Á. and Schamberger, A. and Sándor, S. and Pergel, E. and Varga, N. and Raskó, T. and Izsvák, Z. and Apáti, Á. and Orbán, T.I.
Gene 834 : 146609. 5 August 2022

Gene Therapy

The hyperactive Sleeping Beauty transposase SB100X improves the genetic modification of T cells to express a chimeric antigen receptor.
Jin, Z. and Maiti, S. and Huls, H. and Singh, H. and Olivares, S. and Mates, L. and Izsvak, Z. and Ivics, Z. and Lee, D.A. and Champlin, R.E. and Cooper, L.J.
Gene Therapy 18 (9): 849-856. September 2011

Genome Biology

Ten things you should know about transposable elements.
Bourque, G. and Burns, K.H. and Gehring, M. and Gorbunova, V. and Seluanov, A. and Hammell, M. and Imbeault, M. and Izsvák, Z. and Levin, H.L. and Macfarlan, T.S. and Mager, D.L. and Feschotte, C.
Genome Biology 19 (1): 199. 19 November 2018

Genomic parasites and genome evolution.
Ivics, Z.
Genome Biology 10 (4): 306. 15 April 2009

Technology transfer from worms and flies to vertebrates: transposition-based genome manipulations and their future perspectives.
Mates, L. and Izsvak, Z. and Ivics, Z.
Genome Biology 8 Suppl 1 : S1. 31 October 2007

Genome Dynamics and Stability

Interactions of transposons with the cellular DNA repair machinery.
Izsvak, Z. and Wang, Y. and Ivics, Z.
Genome Dynamics and Stability 4 : 133-176. 2009

Transposon-host cell interactions in the regulation of Sleeping Beauty transposition.
Walisko, O. and Jursch, T. and Izsvak, Z. and Ivics, Z.
Genome Dynamics and Stability 4 : 109-132. 2009

Genome Editing in Stem Cells and Regenerative Biology

Genome engineering using Sleeping Beauty transposition in vertebrates.
Chilkunda, S.S. and Raghunathan, V. and Narayanavari, S.A. and Ivics, Z. and Izsvák, Z.
In: Genome editing and engineering. Cambridge University Press, Cambridge, 249-269. ISBN 9781316756300 July 2018

Genome Research

Retrotransposition creates sloping shores: a graded influence of hypomethylated CpG islands on flanking CpG sites.
Grandi, F.C. and Rosser, J.M. and Newkirk, S.J. and Yin, J. and Jiang, X. and Xing, Z. and Whitmore, L. and Bashir, S. and Ivics, Z. and Izsvák, Z. and Ye, P. and Yu, Y.E. and An, W.
Genome Research 25 (8): 1135-1146. August 2015

A novel active endogenous retrovirus family contributes to genome variability in rat inbred strains.
Wang, Y. and Liska, F. and Gosele, C. and Sedova, L. and Kren, V. and Krenova, D. and Ivics, Z. and Huebner, N. and Izsvak, Z.
Genome Research 20 (1): 19-27. January 2010

Histochemistry and Cell Biology

Placental DAPK1 and autophagy marker LC3B-II are dysregulated by TNF-α in a gestational age-dependent manner.
Prokesch, A. and Blaschitz, A. and Bauer, T. and Moser, G. and Hiden, U. and Zadora, J. and Dechend, R. and Herse, F. and Gauster, M.
Histochemistry and Cell Biology 147 (6): 695-705. June 2017

Human Gene Therapy

Efficient non-viral T cell engineering by Sleeping Beauty minicircles diminishing DNA toxicity and miRNAs silencing the endogenous TCR.
Clauss, J. and Obenaus, M. and Miskey, C. and Ivics, Z. and Izsvák, Z. and Uckert, W. and Bunse, M.
Human Gene Therapy 29 (5): 569-584. May 2018

Wide awake and ready to move: 20 years of non-viral therapeutic genome engineering with the Sleeping Beauty transposon system.
Hodge, R. and Narayanavari, S. and Izsvák, Z. and Ivics, Z.
Human Gene Therapy 28 (10): 842-855. 1 October 2017

Nonviral gene delivery with the Sleeping Beauty transposon system.
Ivics, Z. and Izsvak, Z.
Human Gene Therapy 22 (9): 1043-1051. September 2011

Herpes simplex virus/Sleeping Beauty Vector-based embryonic gene transfer using the HSB5 mutant: loss of apparent transposition hyperactivity in vivo.
de Silva, S. and Mastrangelo, M.A. and Lotta, L.T. and Burris, C.A. and Izsvak, Z. and Ivics, Z. and Bowers, W.J.
Human Gene Therapy 21 (11): 1603-1613. 19 November 2010

Human Gene Therapy Clinical Development

Transposon-based, targeted ex vivo gene therapy to treat age-related macular degeneration (TargetAMD).
Thumann, G. and Perdikomati-Dahmen, M. and Izsvák, Z. and Ivics, Z. and Garcia Layana, A. and Ronchetti, M. and Petrovski, G. and Scherman, D. and Aranda, P. and Pouillot, S. and Binder, S. and Johnen, S. and van den Berg, J.
Human Gene Therapy Clinical Development 26 (2): 97-100. 18 June 2015

Human Gene Therapy Methods

Excision efficiency is not strongly coupled to transgenic rate: cell type dependent transposition efficiency of Sleeping Beauty and piggyBac DNA transposons.
Kolacsek, O. and Erdei, Z. and Apáti, A. and Sándor, S. and Izsvák, Z. and Ivics, Z. and Sarkadi, B. and Orbán, T.I.
Human Gene Therapy Methods 25 (4): 241-252. August 2014

Hypertension

Downregulation of Plzf gene ameliorates metabolic and cardiac traits in the spontaneously hypertensive rat.
Liška, F. and Landa, V. and Zidek, V. and Mlejnek, P. and Šilhavý, J. and Šimáková, M. and Strnad, H. and Trnovská, J. and Škop, V. and Kazdová, L. and Starker, C.G. and Voytas, D.F. and Izsvák, Z. and Mancini, M. and Šeda, O. and Křen, V. and Pravenec, M.
Hypertension 69 (6): 1084-1091. June 2017

International Journal of Biochemistry and Cell Biology

Cloning and characterization of the genes of the CeqI restriction-modification system.
Izsvak, Z. and Jobbagy, Z. and Takacs, I. and Duda, E.
International Journal of Biochemistry and Cell Biology 29 : 895-900. 1 June 1997

International Journal of Molecular Sciences

HMGXB4 targets Sleeping Beauty transposition to germinal stem cells.
Devaraj, A. and Singh, M. and Narayanavari, S.A. and Yong, G. and Chen, J. and Wang, J. and Becker, M. and Walisko, O. and Schorn, A. and Cseresznyés, Z. and Raskó, T. and Radscheit, K. and Selbach, M. and Ivics, Z. and Izsvak, Z.
International Journal of Molecular Sciences 24 (8): 7283. 14 April 2023

Molecular and functional characterization of BDNF-overexpressing human retinal pigment epithelial cells established by sleeping beauty transposon-mediated gene transfer.
Mattern, L. and Otten, K. and Miskey, C. and Fuest, M. and Izsvák, Z. and Ivics, Z. and Walter, P. and Thumann, G. and Johnen, S.
International Journal of Molecular Sciences 23 (21): 12982. 1 November 2022

Analyses of circRNA expression throughout the light-dark cycle reveal a strong regulation of (Cdr1as), associated with light entrainment in the SCN.
Ivanov, A. and Mattei, D. and Radscheit, K. and Compagnion, A.C. and Pett, J.P. and Herzel, H.P. and Paolicelli, R.C. and Piwecka, M. and Meyer, U. and Beule, D.
International Journal of Molecular Sciences 23 (20): 12347. October 2022

International Review of Cell and Molecular Biology

Unique functions of repetitive transcriptomes.
Schumann, G.G. and Gogvadze, E.V. and Osanai-Futahashi, M. and Kuroki, A. and Muenk, C. and Fujiwara, H. and Ivics, Z. and Buzdin, A.A.
International Review of Cell and Molecular Biology 285 : 115-188. 2010

Investigative Ophthalmology & Visual Science

Sleeping Beauty transposon-mediated transfection of retinal and iris pigment epithelial cells.
Johnen, S. and Izsvak, Z. and Stocker, M. and Harmening, N. and Salz, A.K. and Walter, P. and Thumann, G.
Investigative Ophthalmology & Visual Science 53 (8): 4787-4796. 18 July 2012

JCI Insight

Curative in vivo hematopoietic stem cell gene therapy of murine thalassemia using large regulatory elements.
Wang, H. and Georgakopoulou, A. and Li, C. and Liu, Z. and Gil, S. and Bashyam, A. and Yannaki, E. and Anagnostopoulos, A. and Pande, A. and Izsvák, Z. and Papayannopoulou, T. and Lieber, A.
JCI Insight 5 (16): e139538. 20 August 2020

Human endogenous retrovirus HERV-K(HML-2) RNA causes neurodegeneration through Toll-like receptors.
Dembny, P. and Newman, A.G. and Singh, M. and Hinz, M. and Szczepek, M. and Krüger, C. and Adalbert, R. and Dzaye, O. and Trimbuch, T. and Wallach, T. and Kleinau, G. and Derkow, K. and Richard, B.C. and Schipke, C. and Scheidereit, C. and Stachelscheid, H. and Golenbock, D. and Peters, O. and Coleman, M. and Heppner, F.L. and Scheerer, P. and Tarabykin, V. and Ruprecht, K. and Izsvák, Z. and Mayer, J. and Lehnardt, S.
JCI Insight 5 (7): e131093. 9 April 2020

Journal of Biological Chemistry

Involvement of a bifunctional, paired-like DNA-binding domain and a transpositional enhancer in Sleeping Beauty transposition.
Izsvak, Z. and Khare, D. and Behlke, J. and Heinemann, U. and Plasterk, R.H. and Ivics, Z.
Journal of Biological Chemistry 277 (37): 34581-34588. 13 September 2002

Journal of Biotechnology

A DNA-transposon-based approach to functional screening in neural stem cells.
Albieri, I. and Onorati, M. and Calabrese, G. and Moiana, A. and Biasci, D. and Badaloni, A. and Camnasio, S. and Spiliotopoulos, D. and Ivics, Z. and Cattaneo, E. and Consalez, G.G.
Journal of Biotechnology 150 (1): 11-21. 1 October 2010

Journal of Bone and Mineral Research

Efficient generation of osteoclasts from human induced pluripotent stem cells and functional investigations of lethal CLCN7-related osteopetrosis.
Rössler, U. and Hennig, A.F. and Stelzer, N. and Bose, S. and Kopp, J. and Søe, K. and Cyganek, L. and Zifarelli, G. and Ali, S. and von der Hagen, M. and Strässler, E.T. and Hahn, G. and Pusch, M. and Stauber, T. and Izsvák, Z. and Gossen, M. and Stachelscheid, H. and Kornak, U.
Journal of Bone and Mineral Research 36 (8): 1621-1635. August 2021

Journal of Clinical Investigation

Staring at the onco-exaptation: the two-faced medley of an ancient retrovirus, HERVH.
Singh, M. and Kondraskhina, A.M. and Hurst, L.D. and Izsvák, Z.
Journal of Clinical Investigation 133 (14): e172278. 17 July 2023

In vivo hematopoietic stem cell gene therapy ameliorates murine thalassemia intermedia.
Wang, H. and Georgakopoulou, A. and Psatha, N. and Li, C. and Capsali, C. and Samal, H.B. and Anagnostopoulos, A. and Ehrhardt, A. and Izsvák, Z. and Papayannopoulou, T. and Yannaki, E. and Lieber, A.
Journal of Clinical Investigation 129 (2): 598-615. 1 February 2019

Human satellite cells have regenerative capacity and are genetically manipulable.
Marg, A. and Escobar, H. and Gloy, S. and Kufeld, M. and Zacher, J. and Spuler, A. and Birchmeier, C. and Izsvák, Z. and Spuler, S.
Journal of Clinical Investigation 124 (10): 4257-4265. 1 October 2014

Journal of Clinical Medicine

Advancing research and treatment: an overview of clinical trials in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and future perspectives.
Seton, K.A. and Espejo-Oltra, J.A. and Giménez-Orenga, K. and Haagmans, R. and Ramadan, D.J. and Mehlsen, J.
Journal of Clinical Medicine 13 (2): 325. 6 January 2024

Journal of Molecular Biology

Schizophrenia risk candidate protein ZNF804A interacts with STAT2 and influences interferon-mediated gene transcription in mammalian cells.
Klockmeier, K. and Silva Ramos, E. and Raskó, T. and Martí Pastor, A. and Wanker, E.E.
Journal of Molecular Biology 433 (19): 167184. 17 September 2021

Common physical properties of DNA affecting target site selection of Sleeping Beauty and other Tc1/mariner transposable elements.
Vigdal, T.J. and Kaufman, C.D. and Izsvak, Z. and Voytas, D.F. and Ivics, Z.
Journal of Molecular Biology 323 (3): 441-452. 25 October 2002

Sleeping Beauty, a wide host-range transposon vector for genetic transformation in vertebrates.
Izsvak, Z. and Ivics, Z. and Plasterk, R.H.
Journal of Molecular Biology 302 : 93-102. 8 September 2000

Journal of Molecular Evolution

Short inverted-repeat transposable elements in teleost fish and implications for a mechanism of their amplification.
Izsvak, Z. and Ivics, Z. and Shimoda, N. and Mohn, D. and Okamoto, H. and Hackett, P.B.
Journal of Molecular Evolution 48 : 13-21. 1 January 1999

Journal of Molecular Medicine

Targeted gene insertion for molecular medicine.
Voigt, K. and Izsvak, Z. and Ivics, Z.
Journal of Molecular Medicine 86 (11): 1205-1219. November 2008

Journal of Neuroscience

Loss of Piccolo function in rats induces cerebellar network dysfunction and Pontocerebellar Hypoplasia type 3-like phenotypes.
Falck, J. and Bruns, C. and Hoffmann-Conaway, S. and Straub, I. and Plautz, E.J. and Orlando, M. and Munawar, H. and Rivalan, M. and Winter, Y. and Izsvák, Z. and Schmitz, D. and Hamra, F.K. and Hallermann, S. and Curtis Garner, C. and Ackermann, F.
Journal of Neuroscience 40 (14): 2943-2959. 1 April 2020

A multiple Piccolino-RIBEYE interaction supports plate-shaped synaptic ribbons in retinal neurons.
Müller, T.M. and Gierke, K. and Joachimsthaler, A. and Sticht, H. and Izsvák, Z. and Hamra, F.K. and Fejtová, A. and Ackermann, F. and Garner, C.C. and Kremers, J. and Brandstätter, J.H. and Regus-Leidig, H.
Journal of Neuroscience 39 (14): 2606-2619. 3 April 2019

Journal of RNAi and Gene Silencing

Frog Prince transposon-based RNAi vectors mediate efficient gene knockdown in human cells.
Kaufman, C.D. and Izsvak, Z. and Katzer, A. and Ivics, Z.
Journal of RNAi and Gene Silencing 1 (2): 97-104. October 2005

Journal of Thrombosis and Haemostasis

High and long-term von Willebrand factor expression after Sleeping Beauty transposon-mediated gene therapy in a mouse model of severe von Willebrand disease.
Portier, I. and Vanhoorelbeke, K. and Verhenne, S. and Pareyn, I. and Vandeputte, N. and Deckmyn, H. and Goldenberg, D.S. and Samal, H.B. and Singh, M. and Ivics, Z. and Izsvák, Z. and De Meyer, S.F.
Journal of Thrombosis and Haemostasis 16 (3): 592-604. March 2018

Journal of Visualized Experiments

Isolation, culture, and genetic engineering of mammalian primary pigment epithelial cells for non-viral gene therapy.
Bascuas, T. and Kropp, M. and Harmening, N. and Wong, B.M. and Johnen, S. and Izsvák, Z. and Thumann, G.
Journal of Visualized Experiments (168): e62145. 26 February 2021

Electroporation-based genetic modification of primary human pigment epithelial cells using the Sleeping Beauty transposon system.
Johnen, S. and Harmening, N. and Marie, C. and Scherman, D. and Izsvák, Z. and Ivics, Z. and Walter, P. and Thumann, G.
Journal of Visualized Experiments (168): e61987. February 2021

Induction and analysis of oxidative stress in Sleeping Beauty transposon-transfected human retinal pigment epithelial cells.
Bascuas, T. and Kropp, M. and Harmening, N. and Asrih, M. and Izsvák, Z. and Thumann, G.
Journal of Visualized Experiments 2020 (166): e61957. 11 December 2020

Life Medicine

Retrotransposon: a versatile player in human preimplantation development and health.
Qu, Y. and Izsvák, Z. and Wang, J.
Life Medicine 2 (1): 1-3. February 2023

Methods

Sleeping Beauty transposon mutagenesis of the rat genome in spermatogonial stem cells.
Ivics, Z. and Izsvak, Z. and Chapman, K.M. and Hamra, F.K.
Methods 53 (4): 356-365. April 2011

Efficient stable gene transfer into human cells by Sleeping Beauty transposon vectors.
Izsvak, Z. and Chuah, M.K. and VandenDriessche, T. and Ivics, Z.
Methods 49 (3): 287-297. November 2009

Methods in Molecular Biology

The sleeping beauty transposon toolbox.
Ammar, I. and Izsvak, Z. and Ivics, Z.
Methods in Molecular Biology 859 : 229-240. 31 January 2012

Insertional engineering of chromosomes with Sleeping Beauty transposition: an overview.
Grabundzija, I. and Izsvak, Z. and Ivics, Z.
In: Mammalian Chromosome Engineering. Methods in Molecular Biology, 738 . Springer / Humana Press, 69-85. 2011

Transposable elements as plasmid-based vectors for long-term gene transfer into tumors.
Ohlfest, J.R. and Ivics, Z. and Izsvak, Z.
Methods in Molecular Biology 542 (Part 2): 105-116. 2009

Insertional mutagenesis of the mouse germline with Sleeping Beauty transposition.
Takeda, J. and Izsvak, Z. and Ivics, Z.
Methods in Molecular Biology 435 : 109-125. 2008

Microbiology Spectrum

Sleeping Beauty transposition.
Ivics, Z. and Izsvák, Z.
Microbiology Spectrum 3 (2) April 2015

Mobile DNA

Regulation of DNA transposition by CpG methylation and chromatin structure in human cells.
Jursch, T. and Miskey, C. and Izsvák, Z. and Ivics, Z.
Mobile DNA 4 (1): 15. 15 May 2013

Cell division promotes efficient retrotransposition in a stable L1 reporter cell line.
Xie, Y. and Mates, L. and Ivics, Z. and Izsvák, Z. and Martin, S.L. and An, W.
Mobile DNA 4 (1): 1-10. 6 March 2013

Reliable transgene-independent method for determining Sleeping Beauty transposon copy numbers.
Kolacsek, O. and Krizsik, V. and Schamberger, A. and Erdei, Z. and Apati, A. and Varady, G. and Mates, L. and Izsvak, Z. and Ivics, Z. and Sarkadi, B. and Orban, T.I.
Mobile DNA 2 (1): 5. 3 March 2011

The expanding universe of transposon technologies for gene and cell engineering.
Ivics, Z. and Izsvak, Z.
Mobile DNA 1 (1): 25. 7 December 2010

Mobile DNA III

Sleeping Beauty transposition.
Ivics, Z. and Izsvák, Z.
In: Mobile DNA III. ASM Press, Washington, DC, 851-872. ISBN 9781555819200 2015

Molecular Biology and Evolution

A novel gene controls a new structure: piggyBac transposable element-derived 1, unique to mammals, controls mammal-specific neuronal paraspeckles.
Raskó, T. and Pande, A. and Radscheit, K. and Zink, A. and Singh, M. and Sommer, C. and Wachtl, G. and Kolacsek, O. and Inak, G. and Szvetnik, A. and Petrakis, S. and Bunse, M. and Bansal, V. and Selbach, M. and Orbán, T.I. and Prigione, A. and Hurst, L.D. and Izsvák, Z.
Molecular Biology and Evolution 39 (10): msac175. October 2022

Molecular Cell

Healing the wounds inflicted by Sleeping Beauty transposition by double-strand break repair in mammalian somatic cells.
Izsvak, Z. and Stuewe, E.E. and Fiedler, D. and Katzer, A. and Jeggo, P.A. and Ivics, Z.
Molecular Cell 13 (2): 279-290. 1 January 2004

Molecular Marine Biology and Biotechnology

Enhanced incorporation of transgenic DNA into zebrafish chromosomes by a retroviral integration protein.
Ivics, Z. and Izsvak, Z. and Hackett, P.B.
Molecular Marine Biology and Biotechnology 2 (3): 162-173. June 1993

Molecular Phylogenetics and Evolution

Transposition of the bamboo Mariner-like element Ppmar1 in yeast.
Zhou, M.B. and Hu, H. and Miskey, C. and Lazarow, K. and Ivics, Z. and Kunze, R. and Yang, G. and Izsvák, Z. and Tang, D.Q.
Molecular Phylogenetics and Evolution 109 : 367-374. April 2017

Molecular Therapy

Targeting CD33 in chemoresistant AML patient-derived xenografts by CAR-CIK cells modified with an improved SB transposon system.
Rotiroti, M.C. and Buracchi, C. and Arcangeli, S. and Galimberti, S. and Valsecchi, M.G. and Perriello, V.M. and Rasko, T. and Alberti, G. and Magnani, C.F. and Cappuzzello, C. and Lundberg, F. and Pande, A. and Dastoli, G. and Introna, M. and Serafini, M. and Biagi, E. and Izsvák, Z. and Biondi, A. and Tettamanti, S.
Molecular Therapy 28 (9): 1974-1986. 2 September 2020

Efficient non-viral gene delivery into human hematopoietic stem cells by minicircle Sleeping Beauty transposon vectors.
Holstein, M. and Mesa-Nuñez, C. and Miskey, C. and Almarza, E. and Poletti, V. and Schmeer, M. and Grueso, E. and Ordóñez Flores, J.C. and Kobelt, D. and Walther, W. and Aneja, M.K. and Geiger, J, and Bonig, H.B. and Izsvák, Z. and Schleef, M. and Rudolph, C. and Mavilio, F. and Bueren, J.A. and Guenechea, G. and Ivics, Z.
Molecular Therapy 26 (4): 1137-1153. 4 April 2018

Structural determinants of sleeping beauty transposase activity.
Abrusán, G. and Yant, S.R. and Szilágyi, A. and Marsh, J.A. and Mátés, L. and Izsvák, Z. and Barabás, O. and Ivics, Z.
Molecular Therapy 24 (8): 1369-1377. August 2016

Genome-wide profiling reveals remarkable parallels between insertion site selection properties of the MLV retrovirus and the piggyBac transposon in primary human CD4(+) T cells.
Gogol-Döring, A. and Ammar, I. and Gupta, S. and Bunse, M. and Miskey, C. and Chen, W. and Uckert, W. and Schulz, T.F. and Izsvák, Z. and Ivics, Z.
Molecular Therapy 24 (3): 592-606. March 2016

Sleeping Beauty transposon vectors in liver directed gene delivery of LDLR and VLDLR for gene therapy of familial hypercholesterolemia.
Turunen, T.A.K. and Kurkipuro, J. and Heikura, T. and Vuorio, T. and Hytönen, E. and Izsvák, Z. and Ylä-Herttuala, S.
Molecular Therapy 24 (3): 620-635. March 2016

Retargeting Sleeping Beauty transposon insertions by engineered zinc finger DNA-binding domains.
Voigt, K. and Gogol-Doering, A. and Miskey, C. and Chen, W. and Cathomen, T. and Izsvak, Z. and Ivics, Z.
Molecular Therapy 20 (10): 1852-1862. October 2012

Comparative genomic integration profiling of Sleeping Beauty transposons mobilized with high efficacy from integrase-defective lentiviral vectors in primary human cells.
Moldt, B. and Miskey, C. and Staunstrup, N.H. and Gogol-Doering, A. and Bak, R.O. and Sharma, N. and Mates, L. and Izsvak, Z. and Chen, W. and Ivics, Z. and Mikkelsen, J.G.
Molecular Therapy 19 (8): 1499-1510. August 2011

Comparative analysis of transposable element vector systems in human cells.
Grabundzija, I. and Irgang, M. and Mates, L. and Belay, E. and Matrai, J. and Gogol-Doering, A. and Kawakami, K. and Chen, W. and Ruiz, P. and Chuah, M.K. and Vandendriessche, T. and Izsvak, Z. and Ivics, Z.
Molecular Therapy 18 (6): 1200-1209. June 2010

Hybrid lentivirus-transposon vectors with a random integration profile in human cells.
Staunstrup, N.H. and Moldt, B. and Mates, L. and Villesen, P. and Jakobsen, M. and Ivics, Z. and Izsvak, Z. and Mikkelsen, J.G.
Molecular Therapy 17 (7): 1205-1214. July 2009

Transcriptional activities of the Sleeping Beauty transposon and shielding its genetic cargo with insulators.
Walisko, O. and Schorn, A. and Rolfs, F. and Devaraj, A. and Miskey, C. and Izsvak, Z. and Ivics, Z.
Molecular Therapy 16 (2): 359-369. February 2008

Targeted Sleeping Beauty transposition in human cells.
Ivics, Z. and Katzer, A. and Stuewe, E.E. and Fiedler, D. and Knespel, S. and Izsvak, Z.
Molecular Therapy 15 (6): 1137-1144. June 2007

Development of hyperactive Sleeping Beauty transposon vectors by mutational analysis.
Zayed, H. and Izsvak, Z. and Walisko, O. and Ivics, Z.
Molecular Therapy 9 (2): 292-304. 1 February 2004

Sleeping Beauty transposition: biology and applications for molecular therapy.
Izsvak, Z. and Ivics, Z.
Molecular Therapy 9 (2): 147-156. 1 February 2004

Molecular Therapy - Methods and Clinical Development

Safe and efficient in vivo hematopoietic stem cell transduction in nonhuman primates using HDAd5/35++ vectors.
Li, C. and Wang, H. and Gil, S. and Germond, A. and Fountain, C. and Baldessari, A. and Kim, J. and Liu, Z. and Georgakopoulou, A. and Radtke, S. and Raskó, T. and Pande, A. and Chiang, C. and Chin, E. and Yannaki, E. and Izsvak, Z. and Papayannopoulou, T. and Kiem, H.P. and Lieber, A.
Molecular Therapy - Methods and Clinical Development 24 : 127-141. 10 March 2022

Preclinical evaluation of a cell-based gene therapy using the Sleeping Beauty transposon system in choroidal neovascularization.
Hernandez, M. and Recalde, S. and Garcia-Garcia, L. and Bezunartea, J. and Miskey, C. and Johnen, S. and Diarra, S. and Sebe, A. and Rodriguez-Madoz, J.R. and Pouillot, S. and Marie, C. and Izsvák, Z. and Scherman, D. and Kropp, M. and Prosper, F. and Thumann, G. and Ivics, Z. and Garcia-Layana, A. and Fernandez-Robredo, P.
Molecular Therapy - Methods and Clinical Development 15 : 403-417. 13 December 2019

Integrating HDAd5/35++ vectors as a new platform for HSC gene therapy of hemoglobinopathies.
Li, C. and Psatha, N. and Wang, H. and Singh, M. and Samal, H.B. and Zhang, W. and Ehrhardt, A. and Izsvák, Z. and Papayannopoulou, T. and Lieber, A.
Molecular Therapy - Methods and Clinical Development 9 : 142-152. 15 June 2018

A combined in vivo HSC transduction/selection approach results in efficient and stable gene expression in peripheral blood cells in mice.
Wang, H. and Richter, M. and Psatha, N. and Li, C. and Kim, J. and Liu, J. and Ehrhardt, A. and Nilsson, S.K. and Cao, B. and Palmer, D. and Ng, P. and Izsvák, Z. and Haworth, K.G. and Kiem, H.P. and Papayannopoulou, T. and Lieber, A.
Molecular Therapy - Methods and Clinical Development 8 : 52-64. 16 March 2018

Molecular Therapy - Nucleic Acids

The antibiotic-free pFAR4 vector paired with the sleeping beauty transposon sSystem mediates efficient transgene delivery in human cells.
Pastor, M. and Johnen, S. and Harmening, N. and Quiviger, M. and Pailloux, J. and Kropp, M. and Walter, P. and Ivics, Z. and Izsvák, Z. and Thumann, G. and Scherman, D. and Marie, C.
Molecular Therapy - Nucleic Acids 11 : 57-67. 1 June 2018

Long-term PEDF release in rat iris and retinal epithelial cells after Sleeping Beauty transposon-mediated gene delivery.
Garcia-Garcia, L. and Recalde, S. and Hernandez, M. and Bezunartea, J. and Rodriguez-Madoz, J.R. and Johnen, S. and Diarra, S. and Marie, C. and Izsvák, Z. and Ivics, Z. and Scherman, D. and Kropp, M. and Thumann, G. and Prosper, F. and Fernandez-Robredo, P. and Garcia-Layana, A.
Molecular Therapy - Nucleic Acids 9 : 1-11. 15 December 2017

Engineering of PEDF-expressing primary pigment epithelial cells by the SB transposon system delivered by pFAR4 plasmids.
Thumann, G. and Harmening, N. and Prat-Souteyrand, C. and Marie, C. and Pastor, M. and Sebe, A. and Miskey, C. and Hurst, L. and Diarra, S. and Kropp, M. and Walter, P. and Scherman, D. and Ivics, Z. and Izsvák, Z. and Johnen, S.
Molecular Therapy - Nucleic Acids 6 : 302-314. 17 March 2017

Full-length dysferlin transfer by the hyperactive Sleeping Beauty transposase restores dysferlin-deficient muscle.
Escobar, H. and Schöwel, V. and Spuler, S. and Marg, A. and Izsvák, Z.
Molecular Therapy - Nucleic Acids 5 : e277. 19 January 2016

Molecular and Cellular Biology

The Ancient Mariner Sails Again: Transposition of the Human Hsmar1 Element by a Reconstructed Transposase and Activities of the SETMAR Protein on Transposon Ends.
Miskey, C. and Papp, B. and Mates, L. and Sinzelle, L. and Keller, H. and Izsvak, Z. and Ivics, Z.
Molecular and Cellular Biology 27 (12): 4589-4600. 15 June 2007

Molecular and General Genetics

Characterization of a Tc1-like transposable element in zebrafish (Danio rerio).
Izsvak, Z. and Ivics, Z. and Hackett, P.B.
Molecular and General Genetics 247 (3): 312-322. 10 May 1995

Nature

Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells.
Wang, J. and Xie, G. and Singh, M. and Ghanbarian, A.T. and Raskó, T. and Szvetnik, A. and Cai, H. and Besser, D. and Prigione, A. and Fuchs, N.V. and Schumann, G.G. and Chen, W. and Lorincz, M.C. and Ivics, Z. and Hurst, L.D. and Izsvák, Z.
Nature 516 (7531): 405-409. 18 December 2014

Gibbon genome and the fast karyotype evolution of small apes.
Carbone, L. and Harris, R.A. and Gnerre, S. and Veeramah, K.R. and Lorente-Galdos, B. and Huddleston, J. and Meyer, T.J. and Herrero, J. and Roos, C. and Aken, B. and Anaclerio, F. and Archidiacono, N. and Baker, C. and Barrell, D. and Batzer, M.A. and Beal, K. and Blancher, A. and Bohrson, C.L. and Brameier, M. and Campbell, M.S. and Capozzi, O. and Casola, C. and Chiatante, G. and Cree, A. and Damert, A. and de Jong, P.J. and Dumas, L. and Fernandez-Callejo, M. and Flicek, P. and Fuchs, N.V. and Gut, I. and Gut, M. and Hahn, M.W. and Hernandez-Rodriguez, J. and Hillier, L.W. and Hubley, R. and Ianc, B. and Izsvák, Z. and Jablonski, N.G. and Johnstone, L.M. and Karimpour-Fard, A. and Konkel, M.K. and Kostka, D. and Lazar, N.H. and Lee, S.L. and Lewis, L.R. and Liu, Y. and Locke, D.P. and Mallick, S. and Mendez, F.L. and Muffato, M. and Nazareth, L.V. and Nevonen, K.A. and O'Bleness, M. and Ochis, C. and Odom, D.T. and Pollard, K.S. and Quilez, J. and Reich, D. and Rocchi, M. and Schumann, G.G. and Searle, S. and Sikela, J.M. and Skollar, G. and Smit, A. and Sonmez, K. and ten Hallers, B. and Terhune, E. and Thomas, G.W.C. and Ullmer, B. and Ventura, M. and Walker, J.A. and Wall, J.D. and Walter, L. and Ward, M.C. and Wheelan, S.J. and Whelan, C.W. and White, S. and Wilhelm, L.J. and Woerner, A.E. and Yandell, M. and Zhu, B. and Hammer, M.F. and Marques-Bonet, T. and Eichler, E.E. and Fulton, L. and Fronick, C. and Muzny, D.M. and Warren, W.C. and Worley, K.C. and Rogers, J. and Wilson, R.K. and Gibbs, R.A.
Nature 513 (7517): 195-201. 11 September 2014

Hungary's 'reforms' are threatening basic science.
Izsvak, Z. and Ivics, Z. and Mates, L.
Nature 443 (7110): 394. 28 September 2006

Nature Communications

Sleeping Beauty transposase structure allows rational design of hyperactive variants for genetic engineering.
Voigt, F. and Wiedemann, L. and Zuliani, C. and Querques, I. and Sebe, A. and Mátés, L. and Izsvák, Z. and Ivics, Z. and Barabas, O.
Nature Communications 7 : 11126. 30 March 2016

A Helitron transposon reconstructed from bats reveals a novel mechanism of genome shuffling in eukaryotes.
Grabundzija, I. and Messing, S.A. and Thomas, J. and Cosby, R.L. and Bilic, I. and Miskey, C. and Gogol-Döring, A. and Kapitonov, V. and Diem, T. and Dalda, A. and Jurka, J. and Pritham, E.J. and Dyda, F. and Izsvák, Z. and Ivics, Z.
Nature Communications 7 : 10716. 2 March 2016

Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells.
Klawitter, S. and Fuchs, N.V. and Upton, K.R. and Muñoz-Lopez, M. and Shukla, R. and Wang, J. and Garcia-Cañadas, M. and Lopez-Ruiz, C. and Gerhardt, D.J. and Sebe, A. and Grabundzija, I. and Merkert, S. and Gerdes, P. and Pulgarin, J.A. and Bock, A. and Held, U. and Witthuhn, A. and Haase, A. and Sarkadi, B. and Löwer, J. and Wolvetang, E.J. and Martin, U. and Ivics, Z. and Izsvák, Z. and Garcia-Perez, J.L. and Faulkner, G.J. and Schumann, G.G.
Nature Communications 7 : 10286. 8 January 2016

Nature Genetics

Human somatic cell mutagenesis creates genetically tractable sarcomas.
Molyneux, S.D. and Waterhouse, P.D. and Shelton, D. and Shao, Y.W. and Watling, C.M. and Tang, Q.L. and Harris, I.S. and Dickson, B.C. and Tharmapalan, P. and Sandve, G.K. and Zhang, X. and Bailey, S.D. and Berman, H. and Wunder, J.S. and Izsvák, Z. and Lupien, M. and Mak, T.W. and Khokha, R.
Nature Genetics 46 (9): 964-972. September 2014

Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates.
Mates, L. and Chuah, M.K. and Belay, E. and Jerchow, B. and Manoj, N. and Acosta-Sanchez, A. and Grzela, D.P. and Schmitt, A. and Becker, K. and Matrai, J. and Ma, L. and Samara-Kuko, E. and Gysemans, C. and Pryputniewicz, D. and Miskey, C. and Fletcher, B. and Vandendriessche, T. and Ivics, Z. and Izsvak, Z.
Nature Genetics 41 (6): 753-761. June 2009

Progress and prospects in rat genetics: a community view.
Aitman, T.J. and Critser, J.K. and Cuppen, E. and Dominiczak, A. and Fernandez-Suarez, X.M. and Flint, J. and Gauguier, D. and Geurts, A.M. and Gould, M. and Harris, P.C. and Holmdahl, R. and Huebner, N. and Izsvak, Z. and Jacob, H.J. and Kuramoto, T. and Kwitek, A.E. and Marrone, A. and Mashimo, T. and Moreno, C. and Mullins, J. and Mullins, L. and Olsson, T. and Pravenec, M. and Riley, L. and Saar, K. and Serikawa, T. and Shull, J.D. and Szpirer, C. and Twigger, S.N. and Voigt, B. and Worley, K.C.
Nature Genetics 40 (5): 516-22. May 2008

Somatic integration and long-term transgene expression in normal and haemophilic mice using a DNA transposon system.
Yant, S.R. and Meuse, L. and Chiu, W. and Ivics, Z. and Izsvak, Z. and Kay, M.A.
Nature Genetics 25 (1): 35-41. 1 May 2000

Nature Methods

Generating knockout rats by transposon mutagenesis in spermatogonial stem cells.
Izsvak, Z. and Froehlich, J. and Grabundzija, I. and Shirley, J.R. and Powell, H.M. and Chapman, K.M. and Ivics, Z. and Hamra, F.K.
Nature Methods 7 (6): 443-445. June 2010

Transposon-mediated genome manipulation in vertebrates.
Ivics, Z. and Li, M.A. and Mates, L. and Boeke, J.D. and Nagy, A. and Bradley, A. and Izsvak, Z.
Nature Methods 6 (6): 415-422. June 2009

Sleeping Beauty hits them all: transposon-mediated saturation mutagenesis in the mouse germline.
Izsvak, Z. and Ivics, Z.
Nature Methods 2 (10): 735-736. October 2005

Nature Protocols

Isolation and cultivation of naive-like human pluripotent stem cells based on HERVH expression.
Wang, J. and Singh, M. and Sun, C. and Besser, D. and Prigione, A. and Ivics, Z. and Hurst, L.D. and Izsvák, Z.
Nature Protocols 11 (2): 327-346. February 2016

Germline transgenesis in pigs by cytoplasmic microinjection of Sleeping Beauty transposons.
Ivics, Z. and Garrels, W. and Mátés, L. and Yau, T.Y. and Bashir, S. and Zidek, V. and Landa, V. and Geurts, A. and Pravenec, M. and Rülicke, T. and Kues, W.A. and Izsvák, Z.
Nature Protocols 9 (4): 810-827. April 2014

Germline transgenesis in rabbits by pronuclear microinjection of Sleeping Beauty transposons.
Ivics, Z. and Hiripi, L. and Hoffmann, O.I. and Mátés, L. and Yau, T.Y. and Bashir, S. and Zidek, V. and Landa, V. and Geurts, A. and Pravenec, M. and Rülicke, T. and Bösze, Z. and Izsvák, Z.
Nature Protocols 9 (4): 794-809. April 2014

Germline transgenesis in rodents by pronuclear microinjection of Sleeping Beauty transposons.
Ivics, Z. and Mátés, L. and Yau, T.Y. and Landa, V. and Zidek, V. and Bashir, S. and Hoffmann, O.I. and Hiripi, L. and Garrels, W. and Kues, W.A. and Boesze, Z. and Geurts, A. and Pravenec, M. and Rülicke, T. and Izsvák, Z.
Nature Protocols 9 (4): 773-793. April 2014

Sleeping Beauty transposon mutagenesis in rat spermatogonial stem cells.
Ivics, Z. and Izsvak, Z. and Medrano, G. and Chapman, K.M. and Hamra, F.K.
Nature Protocols 6 (10): 1521-1535. October 2011

Nature Reviews Genetics

Selection on synonymous sites: the unwanted transcript hypothesis.
Radrizzani, S. and Kudla, G. and Izsvák, Z. and Hurst, L.D.
Nature Reviews Genetics 31 January 2024 (In Press)

Nucleic Acids Research

A single amino acid switch converts the sleeping beauty transposase into an efficient unidirectional excisionase with utility in stem cell reprogramming.
Kesselring, L. and Miskey, C. and Zuliani, C. and Querques, I. and Kapitonov, V. and Laukó, A. and Fehér, A. and Palazzo, A. and Diem, T. and Lustig, J. and Sebe, A. and Wang, Y. and Dinnyés, A. and Izsvák, Z. and Barabas, O. and Ivics, Z.
Nucleic Acids Research 48 (1): 316-331. 1 January 2020

Regulated complex assembly safeguards the fidelity of Sleeping Beauty transposition.
Wang, Y. and Pryputniewicz-Dobrinska, D. and Nagy, E.E. and Kaufman, C.D. and Singh, M. and Yant, S. and Wang, J. and Dalda, A. and Kay, M.A. and Ivics, Z. and Izsvák, Z.
Nucleic Acids Research 45 (1): 311-326. 9 January 2017

Sleeping Beauty transposon-based system for cellular reprogramming and targeted gene insertion in induced pluripotent stem cells.
Grabundzija, I. and Wang, J. and Sebe, A. and Erdei, Z. and Kajdi, R. and Devaraj, A. and Steinemann, D. and Szuhai, K. and Stein, U. and Cantz, T. and Schambach, A. and Baum, C. and Izsvák, Z. and Sarkadi, B. and Ivics, Z.
Nucleic Acids Research 41 (3): 1829-1847. 1 February 2013

Retargeting transposon insertions by the adeno-associated virus Rep protein.
Ammar, I. and Gogol-Doering, A. and Miskey, C. and Chen, W. and Cathomen, T. and Izsvak, Z. and Ivics, Z.
Nucleic Acids Research 40 (14): 6693-6712. 1 August 2012

Avoiding cytotoxicity of transposases by dose-controlled mRNA delivery.
Galla, M. and Schambach, A. and Falk, C.S. and Maetzig, T. and Kuehle, J. and Lange, K. and Zychlinski, D. and Heinz, N. and Brugman, M.H. and Goehring, G. and Izsvak, Z. and Ivics, Z. and Baum, C.
Nucleic Acids Research 39 (16): 7147-7160. 1 September 2011

Efficient conditional and promoter-specific in vivo expression of cDNAs of choice by taking advantage of recombinase-mediated cassette exchange using FlEx gene traps.
Schebelle, L. and Wolf, C. and Stribl, C. and Javaheri, T. and Schnuetgen, F. and Ettinger, A. and Ivics, Z. and Hansen, J. and Ruiz, P. and von Melchner, H. and Wurst, W. and Floss, T.
Nucleic Acids Research 38 (9): e106. May 2010

The Frog Prince: a reconstructed transposon from Rana pipiens with high transpositional activity in vertebrate cells.
Miskey, C. and Izsvak, Z. and Plasterk, R.H. and Ivics, Z.
Nucleic Acids Research 31 (23): 6873-6881. 1 December 2003

The DNA-bending protein HMGB1 is a cellular cofactor of Sleeping Beauty transposition.
Zayed, H. and Izsvak, Z. and Khare, D. and Heinemann, U. and Ivics, Z.
Nucleic Acids Research 31 (9): 2313-2322. 1 May 2003

PLoS Biology

A new human embryonic cell type associated with activity of young transposable elements allows definition of the inner cell mass.
Singh, M. and Kondrashkina, A. and Widmann, T.J. and Cortes, J.L. and Bansal, V. and Wang, J. and Römer, C. and Garcia-Canadas, M. and Garcia-Perez, J.L. and Hurst, L.D. and Izsvak, Z.
PLoS Biology 21 (6): e3002162. 20 June 2023

PLoS Genetics

Suicidal autointegration of Sleeping Beauty and piggyBac transposons in eukaryotic cells.
Wang, Y. and Wang, J. and Devaraj, A. and Singh, M. and Jimenez Orgaz, A. and Chen, J.X. and Selbach, M. and Ivics, Z. and Izsvák, Z.
PLoS Genetics 10 (3): e1004103. 13 March 2014

PLoS ONE

A simple approach for multi-targeted shRNA-mediated inducible knockdowns using Sleeping Beauty vectors.
Fink, S. and Zugelder, L. and Roth, B. and Brandt, E. and Meloche, S. and Izsvák, Z. and Bargou, R.C. and Stühmer, T.
PLoS ONE 13 (10): e0205585. 19 October 2018

Generation of an immortalized mesenchymal stem cell line producing a secreted biosensor protein for glucose monitoring.
Siska, E.K. and Weisman, I. and Romano, J. and Ivics, Z. and Izsvák, Z. and Barkai, U. and Petrakis, S. and Koliakos, G.
PLoS ONE 12 (9): e0185498. 26 September 2017

Targeting of the Plzf gene in the rat by transcription activator-like effector nuclease results in caudal regression syndrome in spontaneously hypertensive rats.
Liška, F. and Peterková, R. and Peterka, M. and Landa, V. and Zidek, V. and Mlejnek, P. and Šilhavý, J. and Šimáková, M. and Křen, V. and Starker, C.G. and Voytas, D.F. and Izsvák, Z. and Pravenec, M.
PLoS ONE 11 (10): e0164206. 11 October 2016

Genomic analysis of Sleeping Beauty transposon integration in human somatic cells.
Turchiano, G. and Latella, M.C. and Gogol-Döring, A. and Cattoglio, C. and Mavilio, F. and Izsvák, Z. and Ivics, Z. and Recchia, A.
PLoS ONE 9 (11): e112712. 12 November 2014

Hybrid adeno-associated viral vectors utilizing transposase-mediated somatic integration for stable transgene expression in human cells.
Zhang, W. and Solanki, M. and Müther, N. and Ebel, M. and Wang, J. and Sun, C. and Izsvak, Z. and Ehrhardt, A.
PLoS ONE 8 (10): e76771. 8 October 2013

Integration profile and safety of an adenovirus hybrid-vector utilizing hyperactive Sleeping Beauty transposase for somatic integration.
Zhang, W. and Muck-Hausl, M. and Wang, J. and Sun, C. and Gebbing, M. and Miskey, C. and Ivics, Z. and Izsvak, Z. and Ehrhardt, A.
PLoS ONE 8 (10): e75344. 4 October 2013

Genotype-independent transmission of transgenic fluorophore protein by boar spermatozoa.
Garrels, W. and Holler, S. and Taylor, U. and Herrmann, D. and Struckmann, C. and Klein, S. and Barg-Kues, B. and Nowak-Imialek, M. and Ehling, C. and Rath, D. and Ivics, Z. and Niemann, H. and Kues, W.A.
PLoS ONE 6 (11): e27563. 16 November 2011

Germline transgenic pigs by Sleeping Beauty transposition in porcine zygotes and targeted integration in the pig genome.
Garrels, W. and Mates, L. and Holler, S. and Dalda, A. and Taylor, U. and Petersen, B. and Niemann, H. and Izsvak, Z. and Ivics, Z. and Kues, W.A.
PLoS ONE 6 (8): e23573. 29 August 2011

Pathologie Biologie

Elements transposables: des outils permettant la mutagenese et le transgenese chez les vertebres [Transposable elements as tools from mutagenesis and transgenesis of vertebrates].
Plasterk, R.H. and Van Luenen, H. and Vos, C. and Ivics, Z. and Izsvak, Z. and Fischer, S.
Pathologie Biologie 46 : 674-675. 1 November 1998

Proceedings of the National Academy of Sciences of the United States of America

Transposition of a reconstructed Harbinger element in human cells and functional homology with two transposon-derived cellular genes.
Sinzelle, L. and Kapitonov, V.V. and Grzela, D.P. and Jursch, T. and Jurka, J. and Izsvak, Z. and Ivics, Z.
Proceedings of the National Academy of Sciences of the United States of America 105 (12): 4715-4720. 25 March 2008

Sleeping Beauty transposase modulates cell-cycle progression through interaction with Miz-1.
Walisko, O. and Izsvak, Z. and Szabo, K. and Kaufman, C.D. and Herold, S. and Ivics, Z.
Proceedings of the National Academy of Sciences of the United States of America 103 (11): 4062-4067. 14 March 2006

Chromosomal transposition of a Tc1/mariner-like element in mouse embryonic stem cells.
Luo, G. and Ivics, Z. and Izsvak, Z. and Bradley, A.
Proceedings of the National Academy of Sciences of the United States of America 95 (18): 10769-10773. 1 September 1998

Identification of functional domains and evolution of Tc1-like transposable elements.
Ivics, Z. and Izsvak, Z. and Minter, A. and Hackett, P.B.
Proceedings of the National Academy of Sciences of the United States of America 93 (10): 5008-5013. 14 May 1996

DANA elements: a family of composite, tRNA-derived short interspersed DNA elements associated with mutational activities in zebrafish (Danio rerio).
Izsvak, Z. and Ivics, Z. and Garcia-Estefania, D. and Fahrenkrug, S.C. and Hackett, P.B.
Proceedings of the National Academy of Sciences of the United States of America 93 (3): 1077-1081. 6 February 1996

Redox Biology

Nuclear inclusions of pathogenic ataxin-1 induce oxidative stress and perturb the protein synthesis machinery.
Laidou, S. and Alanis-Lobato, G. and Pribyl, J. and Raskó, T. and Tichy, B. and Mikulasek, K. and Tsagiopoulou, M. and Oppelt, J. and Kastrinaki, G. and Lefaki, M. and Singh, M. and Zink, A. and Chondrogianni, N. and Psomopoulos, F. and Prigione, A. and Ivics, Z. and Pospisilova, S. and Skladal, P. and Izsvák, Z. and Andrade-Navarro, M.A. and Petrakis, S.
Redox Biology 32 : 101458. May 2020

Retrovirology

Human endogenous retrovirus K (HML-2) RNA and protein expression is a marker for human embryonic and induced pluripotent stem cells.
Fuchs, N.V. and Loewer, S. and Daley, G.Q. and Izsvák, Z. and Löwer, J. and Löwer, R.
Retrovirology 10 (1): 115. 24 October 2013

Scientific Reports

Naïve-like pluripotency to pave the way for saving the northern white rhinoceros from extinction.
Zywitza, V. and Rusha, E. and Shaposhnikov, D. and Ruiz-Orera, J. and Telugu, N. and Rishko, V. and Hayashi, M. and Michel, G. and Wittler, L. and Stejskal, J. and Holtze, S. and Göritz, F. and Hermes, R. and Wang, J. and Izsvák, Z. and Colleoni, S. and Lazzari, G. and Galli, C. and Hildebrandt, T.B. and Hayashi, K. and Diecke, S. and Drukker, M.
Scientific Reports 12 (1): 3100. 8 March 2022

Seminars in Cancer Biology

Repetitive elements and genome instability.
Ivics, Z. and Izsvak, Z.
Seminars in Cancer Biology 20 (4): 197-199. August 2010

Stem Cell Research

Generation of human induced pluripotent stem cell line from a patient with a long QT syndrome type 2.
Fatima, A. and Ivanyuk, D. and Herms, S. and Heilmann-Heimbach, S. and O'Shea, O. and Chapman, C. and Izsvák, Z. and Farr, M. and Hescheler, J. and Šarić, T.
Stem Cell Research 16 (2): 304-307. March 2016

Stem Cells

Impaired cell reprogramming in non-homologous end joining deficient cells.
Molina-Estevez, F.J. and Lozano, M.L. and Navarro, S. and Torres, Y. and Grabundzija, I. and Ivics, Z. and Samper, E. and Bueren, J.A. and Guenechea, G.
Stem Cells 31 (8): 1726-1730. August 2013

Novel hyperactive transposons for genetic modification of induced puripotent and adult stem cells: a non-viral paradigm for coaxed differentiation.
Belay, E. and Matrai, J. and Acosta-Sanchez, A. and Ma, L. and Quattrocelli, M. and Mates, L. and Sancho-Bru, P. and Geraerts, M. and Yan, B. and Vermeesch, J. and Rincon, M.Y. and Samara-Kuko, E. and Ivics, Z. and Verfaillie, C.M. and Sampaolesi, M. and Izsvak, Z. and Vandendriessche, T. and Chuah, M.K.
Stem Cells 28 (10): 1760-1771. October 2010

Applying a "double-feature" promoter to identify cardiomyocytes differentiated from human embryonic stem cells following transposon-based gene delivery.
Orban, T.I. and Apati, A. and Nemeth, A. and Varga, N. and Krizsik, V. and Schamberger, A. and Szebenyi, K. and Erdei, Z. and Varady, G. and Karaszi, E. and Homolya, L. and Nemet, K. and Gocza, E. and Miskey, C. and Mates, L. and Ivics, Z. and Izsvak, Z. and Sarkadi, B.
Stem Cells 27 (5): 1077-1087. 20 February 2009

Stem Cells and Development

Derivation and characterization of Sleeping Beauty transposon-mediated porcine induced pluripotent stem cells.
Kues, W.A. and Herrmann, D. and Barg-Kues, B. and Meena Haridoss, S. and Nowak-Imialek, M. and Buchholz, T. and Streeck, M. and Grebe, A. and Grabundzija, I. and Merkert, S. and Martin, U. and Hall, V.J. and Rasmussen, M.A. and Ivics, Z. and Maddox-Hyttel, P. and Niemann, H.
Stem Cells and Development 22 (1): 124-135. 1 January 2013

Transgenic Research

Identification and re-addressing of a transcriptionally permissive locus in the porcine genome.
Garrels, W. and Mukherjee, A. and Holler, S. and Cleve, N. and Talluri, T.R. and Barg-Kues, B. and Diederich, M. and Köhler, P. and Petersen, B. and Lucas-Hahn, A. and Niemann, H. and Izsvák, Z. and Ivics, Z. and Kues, W.A.
Transgenic Research 25 (1): 63-70. February 2016

Trends in Genetics

Gene therapy with the Sleeping Beauty transposon system.
Kebriaei, P. and Izsvák, Z. and Narayanavari, S.A. and Singh, H. and Ivics, Z.
Trends in Genetics 33 (11): 852-870. November 2017

A whole lotta jumpin' goin' on: new transposon tools for vertebrate functional genomics.
Ivics, Z. and Izsvak, Z.
Trends in Genetics 21 (1): 8-11. 1 January 2005

Resident aliens: the Tc1/mariner superfamily of transposable elements.
Plasterk, R.H. and Izsvak, Z. and Ivics, Z.
Trends in Genetics 15 : 326-332. 1 August 1999

Viruses

Human endogenous retrovirus K rec forms a regulatory loop with MITF that opposes the progression of melanoma to an invasive stage.
Singh, M. and Cai, H. and Bunse, M. and Feschotte, C. and Izsvák, Z.
Viruses 12 (11): 1303. 13 November 2020

Zeitschrift fuer Naturforschung C, A Journal of Biosciences

Purification and characterization of CeqI restriction endonuclease.
Izsvak, Z. and Jobbagy, Z. and Duda, E.
Zeitschrift fuer Naturforschung C, A Journal of Biosciences 47 : 830-834. 1 November 1992

Zuechtungskunde

Transgene Expression durch zytoplasmatische Injektion von Plasmiden und Transposon-basierten Konstrukten in Saeugerembryonen [Transgenetic expression by cytoplasmic injection of plasmids and trans­poson-based constructs in mammalian embryos].
Garrels, W. and Holler, S. and Ivics, Z. and Niemann, H. and Kues, W.A.
Zuechtungskunde 83 (1): 47-67. January 2011

bioRxiv

PiggyBac transposable element-derived 1 controls neuronal progenitor identity, stress sensing and mammal-specific paraspeckles.
Raskó, T. and Pande, A. and Radscheit, K. and Zink, A. and Singh, M. and Sommer, C. and Wachtl, G. and Kolacsek, O. and Inak, G. and Szvetnik, A. and Petrakis, S. and Bunse, M. and Bansal, V. and Selbach, M. and Orbán, T. and Prigione, A. and Hurst, L.D. and Izsvák, Z.
bioRxiv : 2021.05.19.444448. 19 May 2021

HMGXB4 targets Sleeping Beauty transposition to vertebrate germinal stem sells.
Devaraj, A. and Singh, M. and Narayanavari, S. and Yong, G. and Wang, J. and Wang, J. and Becker, M. and Walisko, O. and Schorn, A. and Cseresznyés, Z. and Grzela, D. and Raskó, T. and Selbach, M. and Ivics, Z. and Izsvák, Z.
bioRxiv : 2020.06.15.145656. 15 June 2020

Human endogenous retrovirus K Rec forms a regulatory loop with MITF that opposes the progression of melanoma to an invasive stage.
Singh, M. and Cai, H. and Bunse, M. and Feschotte, C. and Izsvak, Z.
bioRxiv : 2020.05.27.120170. 2 June 2020

Loss of Piccolo function in rats induces Pontocerebellar Hypoplasia type 3-like phenotypes.
Falck, J. and Bruns, C. and Hoffmann, S. and Straub, I. and Plautz, E.J. and Orlando, M. and Munawar, H. and Rivalan, M. and Winter, Y. and Izsvák, Z. and Schmitz, D. and Hamra, F.K. and Hallermann, S. and Garner, C. and Ackermann, F.
bioRxiv : 774422. 19 September 2019

Human endogenous retrovirus HERV-K(HML-2) RNA causes neurodegeneration through Toll-like receptors.
Dembny, P. and Newman, A.G. and Singh, M. and Hinz, M. and Szczepek, M. and Krüger, C. and Adalbert, R. and al-Dzaye, O. and Trimbuch, T. and Wallach, T. and Kleinau, G. and Derkow, K. and Richard, B.C. and Schipke, C. and Scheidereit, C. and Golenbock, D. and Peters, O. and Coleman, M. and Heppner, F.L. and Scheerer, P. and Tarabykin, V. and Ruprecht, K. and Izsvák, Z. and Mayer, J. and Lehnardt, S.
bioRxiv : 721241. 1 August 2019

Mutant screen reveals the Piccolo's control over depression and brain-gonad crosstalk.
Medrano, G.A. and Singh, M. and Plautz, E.J. and Good, L.B. and Chapman, K.M. and Chaudhary, J. and Jaichander, P. and Powell, H.M. and Pudasaini, A. and Shelton, J.M. and Richardson, J.A. and Xie, X.J. and Ivics, Z. and Braun, C. and Ackermann, F. and Garner, C.C. and Izsvak, Z. and Hamra, F.K.
bioRxiv : 405985. 31 August 2018

Critical role for Piccolo in synaptic vesicle retrieval.
Ackermann, F. and Schink, K.O. and Bruns, C. and Izsvak, Z. and Hamra, K. and Rosenmund, C. and Garner, C.C.
bioRxiv : 330050. 24 May 2018

The phylogenetically distinct early human embryo.
Singh, M. and Widmann, T.J. and Cortes, J.L. and Schumann, G.G. and Wunderlich, S. and Martin, U. and Garcia-Perez, J.L. and Hurst, L.D. and Izsvak, Z.
bioRxiv : 318329. 18 May 2018

eLife

Critical role for piccolo in synaptic vesicle retrieval.
Ackermann, F. and Schink, K.O. and Bruns, C. and Izsvák, Z. and Hamra, F.K. and Rosenmund, C. and Garner, C.C.
eLife 8 : e46629. 10 May 2019