Helmholtz Gemeinschaft


Interactions of transposons with the cellular DNA repair machinery

Item Type:Review
Title:Interactions of transposons with the cellular DNA repair machinery
Creators Name:Izsvak, Z., Wang, Y. and Ivics, Z.
Abstract:Transposons are ubiquitous components of both prokaryotic and eukaryotic genomes. Transposons are mobile genetic elements whose movement inherently involves the generation of various types of DNA damage in the genome. Since transposons generally do not encode DNA repair functions, the damage is left to be repaired by the host cell. Transposon-inflicted DNA damage ranges from single-base mismatches to the most severe double-strand breaks, and alert specific DNA repair pathways. The interaction between transposons and the host repair machinery is not necessarily a passive process. The host evolves inhibitory strategies against transposition, whereas transposons try to quench damage signaling and escape from inhibitory regulations. Moreover, certain transposons are able to "sense" activation of DNA damage signaling pathways that may eventually trigger transposition. The DNA repair machinery can even be piggybacked by transposons to support transposon amplification. This review focuses on the complex interactions of transposable elements with the DNA repair machinery. Additionally, the impact of mobile elements on genome stability is discussed.
Source:Genome Dynamics and Stability
Series Name:Genome Dynamics and Stability
Title of Book:Transposons and the Dynamic Genome
Page Range:133-176
Number of Pages:44
Official Publication:https://doi.org/10.1007/7050_2008_043

Repository Staff Only: item control page

Open Access
MDC Library