2026
Selective depletion of autoreactive plasma cells as a novel strategy to treat acetylcholine receptor antibody-positive myasthenia gravis.
Khodadadi, Laleh, Puppe, Deborah, Cirillo, Dilara S., Martinez-Cingolani, Carolina, Klotsche, Jens, Pelz, Andreas, Kohler, Siegfried, Cheng, Qingyu 
ORCID: https://orcid.org/0000-0002-0571-1421, Lazaridis, Konstantinos, Fichtner, Michael ORCID: https://orcid.org/0000-0002-5640-7454, Pille, Jan, Kruglov, Andrey ORCID: https://orcid.org/0000-0002-4597-2087, Bondareva, Marina, Alexander, Tobias ORCID: https://orcid.org/0000-0003-1193-0097, Radbruch, Andreas ORCID: https://orcid.org/0000-0001-5753-0000, Meisel, Andreas and Hiepe, Falk ORCID: https://orcid.org/0000-0003-3584-5292
European Journal of Immunology 56
(4): e70166.
April 2026
Additional file 1 of Endogenous retroviral elements LTR8B and MER65 rewire PSG9 regulation to control trophoblast syncytialization and pre-eclampsia risk.
Singh, Manvendra ORCID: https://orcid.org/0000-0002-8626-5418, Qu, Yuliang ORCID: https://orcid.org/0000-0002-6203-0032, Pande, Amit ORCID: https://orcid.org/0009-0008-0826-973X, Zadora, Julianna ORCID: https://orcid.org/0000-0002-6906-7815, Herse, Florian ORCID: https://orcid.org/0000-0002-9305-8134, Gauster, Martin, Kong, Xuhui, Zheng, Rongyan, Anwar, Rabia, Stevanovic, Katarina, Dechend, Ralf ORCID: https://orcid.org/0000-0001-6636-3080, Cohen, Marie, Molvarec, Attila, Wang, Jichang ORCID: https://orcid.org/0000-0002-7027-0298, Konkel, Miriam K., Zhang, Bin ORCID: https://orcid.org/0000-0001-8835-8370, Feschotte, Cedric, Dveksler, Gabriela, Blois, Sandra M. ORCID: https://orcid.org/0000-0002-0434-2660, Hurst, Laurence D. and Izsvák, Zsuzsanna ORCID: https://orcid.org/0000-0002-2053-2384
[Dataset]
9 March 2026
Endogenous retroviral elements LTR8B and MER65 rewire PSG9 regulation to control trophoblast syncytialization and pre-eclampsia risk.
Singh, Manvendra ORCID: https://orcid.org/0000-0002-8626-5418, Qu, Yuliang ORCID: https://orcid.org/0000-0002-6203-0032, Pande, Amit ORCID: https://orcid.org/0009-0008-0826-973X, Zadora, Julianna ORCID: https://orcid.org/0000-0002-6906-7815, Herse, Florian ORCID: https://orcid.org/0000-0002-9305-8134, Gauster, Martin, Kong, Xuhui, Zheng, Rongyan, Anwar, Rabia, Stevanovic, Katarina, Dechend, Ralf ORCID: https://orcid.org/0000-0001-6636-3080, Cohen, Marie, Molvarec, Attila, Wang, Jichang ORCID: https://orcid.org/0000-0002-7027-0298, Konkel, Miriam K., Zhang, Bin ORCID: https://orcid.org/0000-0001-8835-8370, Feschotte, Cedric, Dveksler, Gabriela, Blois, Sandra M., Hurst, Laurence D. and Izsvak, Zsuzsanna ORCID: https://orcid.org/0000-0002-2053-2384
Genome Biology 27
(1): 73.
9 March 2026
Analysis of retroviral MLT1 enhancer-driven genes identifies over-expression of EPS8L1 as an early-stage initiator of both oxidative stress and poor trophoblast invasiveness in the pregnancy disorder preeclampsia.
Hurst, L., Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Anwar, R. and Pande, A. ORCID: https://orcid.org/0009-0008-0826-973X
[Dataset]
2 March 2026
2025
Additional file 10 of ERV3-MLT1 provides cis-regulatory elements for human placental functioning and are commonly dysregulated in human-specific preeclampsia.
Anwar, Rabia, Pande, Amit ORCID: https://orcid.org/0009-0008-0826-973X, Singh, Manvendra ORCID: https://orcid.org/0000-0002-8626-5418, Huang, Zhi ORCID: https://orcid.org/0000-0002-8993-4912, Hallett, Eve ORCID: https://orcid.org/0009-0002-8268-8074, Xie, Yiran, Gellhaus, Alexandra, Herse, Florian ORCID: https://orcid.org/0000-0002-9305-8134, Nonn, Olivia ORCID: https://orcid.org/0000-0001-6385-2866, Gauster, Martin, Raskó, Tamás, Selbach, Matthias ORCID: https://orcid.org/0000-0003-2454-8751, Verlohren, Stefan ORCID: https://orcid.org/0000-0003-3507-8636, Staff, Anne Cathrine, Dechend, Ralf ORCID: https://orcid.org/0000-0001-6636-3080, Pecks, Ulrich, Blois, Sandra M. ORCID: https://orcid.org/0000-0002-0434-2660, Hurst, Laurence D. and Izsvák, Zsuzsanna ORCID: https://orcid.org/0000-0002-2053-2384
[Dataset]
5 November 2025
ERV3-MLT1 provides cis-regulatory elements for human placental functioning and are commonly dysregulated in human-specific preeclampsia.
Anwar, Rabia, Pandey, Amit ORCID: https://orcid.org/0000-0002-8886-1694, Singh, Manvendra ORCID: https://orcid.org/0000-0002-8626-5418, Huang, Zhi ORCID: https://orcid.org/0000-0002-8993-4912, Hallett, Eve ORCID: https://orcid.org/0009-0002-8268-8074, Xie, Yiran, Gellhaus, Alexandra, Herse, Florian ORCID: https://orcid.org/0000-0002-9305-8134, Nonn, Olivia ORCID: https://orcid.org/0000-0001-6385-2866, Gauster, Martin, Raskó, Tamás, Selbach, Matthias ORCID: https://orcid.org/0000-0003-2454-8751, Verlohren, Stefan ORCID: https://orcid.org/0000-0003-3507-8636, Staff, Anne Cathrine, Dechend, Ralf ORCID: https://orcid.org/0000-0001-6636-3080, Pecks, Ulrich, Blois, Sandra M. ORCID: https://orcid.org/0000-0002-0434-2660, Hurst, Laurence D and Izsvák, Zsuzsanna ORCID: https://orcid.org/0000-0002-2053-2384
Genome Biology 26
(1): 364.
5 November 2025
Bisulphite MLT1F2.
Anwar, Rabia
[Dataset]
10 October 2025
Effect of degeneration stage on non-viral tissue transfection of rd10 retina ex vivo.
Zhang, J. ORCID: https://orcid.org/0009-0004-2103-088X, Bing, Z., Marie, C., Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Müller, F., Thumann, G., Walter, P. and Johnen, S.
Molecular Therapy Nucleic Acids 36
(3): 102616.
9 September 2025
Additional file 2 of Co-option of an endogenous retrovirus (LTR7-HERVH) in early human embryogenesis: becoming useful and going unnoticed.
Izsvák, Zsuzsanna ORCID: https://orcid.org/0000-0002-2053-2384, Ma, Jin, Singh, Manvendra ORCID: https://orcid.org/0000-0002-8626-5418 and Hurst, Laurence D.
[Dataset]
5 July 2025
Co-option of an endogenous retrovirus (LTR7-HERVH) in early human embryogenesis: becoming useful and going unnoticed.
Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Ma, J., Singh, M. ORCID: https://orcid.org/0000-0002-8626-5418 and Hurst, L.D.
Mobile DNA 16
(1): 27.
5 July 2025
2024
Non-viral targeted insertion of large payloads into T cells.
Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384
Nature Biomedical Engineering 8
(12): 1516-1517.
December 2024
Atypical KCNQ1/Kv7 channel function in a neonatal diabetes patient: hypersecretion preceded the failure of pancreatic β-cells.
Zhou, Z., Gong, M. ORCID: https://orcid.org/0000-0001-7384-3429, Pande, A. ORCID: https://orcid.org/0009-0008-0826-973X, Margineanu, A. ORCID: https://orcid.org/0000-0002-6634-9729, Lisewski, U., Purfürst, B. ORCID: https://orcid.org/0000-0002-9887-7577, Zhu, H., Liang, L., Jia, S. ORCID: https://orcid.org/0000-0001-8595-9314, Froehler, S. ORCID: https://orcid.org/0000-0001-8000-2927, Zeng, C., Kühnen, P., Khodaverdi, S., Krill, W., Röpke, T., Chen, W. ORCID: https://orcid.org/0000-0003-3263-1627, Raile, K. ORCID: https://orcid.org/0000-0002-0842-1737, Sander, M. ORCID: https://orcid.org/0000-0001-5308-7785 and Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384
iScience 27
(7): 110291.
19 July 2024
Selection on synonymous sites: the unwanted transcript hypothesis.
Radrizzani, S. ORCID: https://orcid.org/0000-0003-0834-8151, Kudla, G. ORCID: https://orcid.org/0000-0002-7924-2744, Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384 and Hurst, L.D. ORCID: https://orcid.org/0000-0002-1002-1054
Nature Reviews Genetics 25
(6): 431-448.
June 2024
Preeclampsia sample 6.
Pandey, Amit ORCID: https://orcid.org/0000-0002-8886-1694
[Dataset]
8 April 2024
Advancing research and treatment: an overview of clinical trials in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and future perspectives.
Seton, K.A. ORCID: https://orcid.org/0000-0002-5657-296X, Espejo-Oltra, J.A. ORCID: https://orcid.org/0000-0002-8036-3260, Giménez-Orenga, K. ORCID: https://orcid.org/0000-0001-9790-7327, Haagmans, R. ORCID: https://orcid.org/0000-0003-2090-6056, Ramadan, D.J. and Mehlsen, J.
Journal of Clinical Medicine 13
(2): 325.
6 January 2024
2023
Staring at the onco-exaptation: the two-faced medley of an ancient retrovirus, HERVH.
Singh, M. ORCID: https://orcid.org/0000-0002-8626-5418, Kondraskhina, A.M. ORCID: https://orcid.org/0000-0001-9065-7177, Hurst, L.D. and Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384
Journal of Clinical Investigation 133
(14): e172278.
17 July 2023
A new human embryonic cell type associated with activity of young transposable elements allows definition of the inner cell mass.
Singh, M. ORCID: https://orcid.org/0000-0002-8626-5418, Kondrashkina, A. ORCID: https://orcid.org/0000-0001-9065-7177, Widmann, T.J., Cortes, J.L., Bansal, V. ORCID: https://orcid.org/0000-0002-0944-7226, Wang, J. ORCID: https://orcid.org/0000-0002-7027-0298, Römer, C., Garcia-Canadas, M., Garcia-Perez, J.L., Hurst, L.D. and Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384
PLoS Biology 21
(6): e3002162.
20 June 2023
HMGXB4 targets Sleeping Beauty transposition to germinal stem cells.
Devaraj, A. ORCID: https://orcid.org/0000-0002-8685-6728, Singh, M. ORCID: https://orcid.org/0000-0002-8626-5418, Narayanavari, S.A. ORCID: https://orcid.org/0000-0002-6997-4829, Yong, G. ORCID: https://orcid.org/0009-0003-3975-0474, Chen, J. ORCID: https://orcid.org/0000-0002-3671-553X, Wang, J. ORCID: https://orcid.org/0000-0002-7027-0298, Becker, M., Walisko, O., Schorn, A., Cseresznyés, Z. ORCID: https://orcid.org/0000-0002-6574-2588, Raskó, T., Radscheit, K., Selbach, M. ORCID: https://orcid.org/0000-0003-2454-8751, Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658 and Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384
International Journal of Molecular Sciences 24
(8): 7283.
14 April 2023
Enhanced biosafety of the Sleeping Beauty transposon system by using mRNA as source of transposase to efficiently and stably transfect retinal pigment epithelial cells.
Harmening, N. ORCID: https://orcid.org/0000-0003-2644-5879, Johnen, S. ORCID: https://orcid.org/0000-0003-0028-2557, Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Kropp, M., Bascuas, T. ORCID: https://orcid.org/0000-0002-3011-2201, Walter, P. ORCID: https://orcid.org/0000-0001-8745-6593, Kreis, A., Pajic, B. ORCID: https://orcid.org/0000-0003-1987-6232 and Thumann, G.
Biomolecules 13
(4): 658.
7 April 2023
Retrotransposon: a versatile player in human preimplantation development and health.
Qu, Y. ORCID: https://orcid.org/0000-0002-6203-0032, Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384 and Wang, J. ORCID: https://orcid.org/0000-0002-7027-0298
Life Medicine 2
(1): 1-3.
February 2023
2022
Molecular and functional characterization of BDNF-overexpressing human retinal pigment epithelial cells established by sleeping beauty transposon-mediated gene transfer.
Mattern, L. ORCID: https://orcid.org/0000-0003-1233-5652, Otten, K., Miskey, C. ORCID: https://orcid.org/0000-0002-7566-9556, Fuest, M. ORCID: https://orcid.org/0000-0002-0573-2599, Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Walter, P., Thumann, G. and Johnen, S. ORCID: https://orcid.org/0000-0003-0028-2557
International Journal of Molecular Sciences 23
(21): 12982.
1 November 2022
GMP-grade manufacturing and quality control of a non-virally engineered advanced therapy medicinal product for personalized treatment of age-related macular degeneration.
Kropp, M., Harmening, N. ORCID: https://orcid.org/0000-0003-2644-5879, Bascuas, T., Johnen, S. ORCID: https://orcid.org/0000-0003-0028-2557, De Clerck, E., Fernández, V., Ronchetti, M., Cadossi, R., Zanini, C. ORCID: https://orcid.org/0000-0002-6554-2113, Scherman, D., Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Marie, C. ORCID: https://orcid.org/0000-0001-9619-5700, Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384 and Thumann, G.
Biomedicines 10
(11): 2777.
November 2022
A novel gene controls a new structure: piggyBac transposable element-derived 1, unique to mammals, controls mammal-specific neuronal paraspeckles.
Raskó, T., Pande, A. ORCID: https://orcid.org/0009-0008-0826-973X, Radscheit, K., Zink, A. ORCID: https://orcid.org/0000-0002-8489-6339, Singh, M. ORCID: https://orcid.org/0000-0002-8626-5418, Sommer, C., Wachtl, G., Kolacsek, O., Inak, G., Szvetnik, A., Petrakis, S., Bunse, M. ORCID: https://orcid.org/0000-0002-7554-2520, Bansal, V. ORCID: https://orcid.org/0000-0002-0944-7226, Selbach, M. ORCID: https://orcid.org/0000-0003-2454-8751, Orbán, T.I., Prigione, A. ORCID: https://orcid.org/0000-0001-9457-1952, Hurst, L.D. ORCID: https://orcid.org/0000-0002-1002-1054 and Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384
Molecular Biology and Evolution 39
(10): msac175.
October 2022
Analyses of circRNA expression throughout the light-dark cycle reveal a strong regulation of (Cdr1as), associated with light entrainment in the SCN.
Ivanov, A. ORCID: https://orcid.org/0000-0002-4824-1925, Mattei, D. ORCID: https://orcid.org/0000-0001-6221-9321, Radscheit, K., Compagnion, A.C., Pett, J.P. ORCID: https://orcid.org/0000-0002-5249-444X, Herzel, H.P. ORCID: https://orcid.org/0000-0003-0414-7889, Paolicelli, R.C. ORCID: https://orcid.org/0000-0001-6851-0849, Piwecka, M. ORCID: https://orcid.org/0000-0003-4104-6577, Meyer, U. ORCID: https://orcid.org/0000-0001-7244-0345 and Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632
International Journal of Molecular Sciences 23
(20): 12347.
October 2022
Functional indications for transposase domestications - characterization of the human piggyBac transposase derived (PGBD) activities.
Kolacsek, O., Wachtl, G., Fóthi, Á., Schamberger, A., Sándor, S., Pergel, E., Varga, N., Raskó, T., Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Apáti, Á. and Orbán, T.I.
Gene 834
: 146609.
5 August 2022
Recapitulating early human development with 8C-like cells.
Yu, X., Liang, S., Chen, M., Yu, H., Li, R., Qu, Y., Kong, X., Guo, R., Zheng, R., Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Sun, C., Yang, M. and Wang, J. ORCID: https://orcid.org/0000-0002-7027-0298
Cell Reports 39
(12): 110994.
21 June 2022
Safe and efficient in vivo hematopoietic stem cell transduction in nonhuman primates using HDAd5/35++ vectors.
Li, C., Wang, H., Gil, S., Germond, A., Fountain, C., Baldessari, A., Kim, J. ORCID: https://orcid.org/0000-0001-5301-8130, Liu, Z., Georgakopoulou, A. ORCID: https://orcid.org/0000-0003-1541-7549, Radtke, S., Raskó, T., Pande, A. ORCID: https://orcid.org/0009-0008-0826-973X, Chiang, C., Chin, E. ORCID: https://orcid.org/0000-0003-0888-5213, Yannaki, E. ORCID: https://orcid.org/0000-0002-9849-1279, Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Papayannopoulou, T. ORCID: https://orcid.org/0000-0002-4523-1393, Kiem, H.P. ORCID: https://orcid.org/0000-0001-5949-4947 and Lieber, A. ORCID: https://orcid.org/0000-0001-6742-6266
Molecular Therapy - Methods and Clinical Development 24
: 127-141.
10 March 2022
Naïve-like pluripotency to pave the way for saving the northern white rhinoceros from extinction.
Zywitza, V. ORCID: https://orcid.org/0000-0003-3055-8569, Rusha, E., Shaposhnikov, D., Ruiz-Orera, J. ORCID: https://orcid.org/0000-0002-8317-0034, Telugu, N. ORCID: https://orcid.org/0000-0003-4509-7056, Rishko, V., Hayashi, M., Michel, G., Wittler, L., Stejskal, J., Holtze, S., Göritz, F., Hermes, R., Wang, J. ORCID: https://orcid.org/0000-0002-7027-0298, Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Colleoni, S., Lazzari, G., Galli, C., Hildebrandt, T.B., Hayashi, K., Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992 and Drukker, M.
Scientific Reports 12
(1): 3100.
8 March 2022
Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells.
Yang, M., Yu, H., Yu, X., Liang, S., Hu, Y., Luo, Y., Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Sun, C. and Wang, J. ORCID: https://orcid.org/0000-0002-7027-0298
Cell Stem Cell 29
(3): 400-418.e13.
3 March 2022
2021
Schizophrenia risk candidate protein ZNF804A interacts with STAT2 and influences interferon-mediated gene transcription in mammalian cells.
Klockmeier, K., Silva Ramos, E. ORCID: https://orcid.org/0000-0002-8520-9107, Raskó, T., Martí Pastor, A. and Wanker, E.E. ORCID: https://orcid.org/0000-0001-8072-1630
Journal of Molecular Biology 433
(19): 167184.
17 September 2021
Efficient generation of osteoclasts from human induced pluripotent stem cells and functional investigations of lethal CLCN7-related osteopetrosis.
Rössler, U. ORCID: https://orcid.org/0000-0003-1969-333X, Hennig, A.F. ORCID: https://orcid.org/0000-0002-3942-3209, Stelzer, N. ORCID: https://orcid.org/0000-0001-9822-5694, Bose, S., Kopp, J. ORCID: https://orcid.org/0000-0002-0391-1497, Søe, K. ORCID: https://orcid.org/0000-0001-7402-314X, Cyganek, L. ORCID: https://orcid.org/0000-0001-9120-1382, Zifarelli, G. ORCID: https://orcid.org/0000-0001-5567-8300, Ali, S. ORCID: https://orcid.org/0000-0002-0351-1645, von der Hagen, M. ORCID: https://orcid.org/0000-0003-2203-7229, Strässler, E.T. ORCID: https://orcid.org/0000-0002-5286-9686, Hahn, G., Pusch, M. ORCID: https://orcid.org/0000-0002-8644-8847, Stauber, T. ORCID: https://orcid.org/0000-0003-0727-6109, Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Gossen, M. ORCID: https://orcid.org/0000-0002-1761-4063, Stachelscheid, H. ORCID: https://orcid.org/0000-0002-9283-4605 and Kornak, U. ORCID: https://orcid.org/0000-0002-4582-9838
Journal of Bone and Mineral Research 36
(8): 1621-1635.
August 2021
Single-dose MGTA-145/plerixafor leads to efficient mobilization and in vivo transduction of HSCs with thalassemia correction in mice.
Li, C., Goncalves, K.A., Raskó, T., Pande, A. ORCID: https://orcid.org/0009-0008-0826-973X, Gil, S., Liu, Z., Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Papayannopoulou, T., Davis, J.C., Kiem, H.P. and Lieber, A.
Blood Advances 5
(5): 1239-1249.
9 March 2021
Isolation, culture, and genetic engineering of mammalian primary pigment epithelial cells for non-viral gene therapy.
Bascuas, T., Kropp, M., Harmening, N., Wong, B.M., Johnen, S., Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384 and Thumann, G.
Journal of Visualized Experiments
(168): e62145.
26 February 2021
Electroporation-based genetic modification of primary human pigment epithelial cells using the Sleeping Beauty transposon system.
Johnen, S., Harmening, N., Marie, C., Scherman, D., Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Walter, P. and Thumann, G.
Journal of Visualized Experiments
(168): e61987.
February 2021
2020
Induction and analysis of oxidative stress in Sleeping Beauty transposon-transfected human retinal pigment epithelial cells.
Bascuas, T., Kropp, M., Harmening, N., Asrih, M., Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384 and Thumann, G.
Journal of Visualized Experiments 2020
(166): e61957.
11 December 2020
Human endogenous retrovirus K rec forms a regulatory loop with MITF that opposes the progression of melanoma to an invasive stage.
Singh, M. ORCID: https://orcid.org/0000-0002-8626-5418, Cai, H., Bunse, M. ORCID: https://orcid.org/0000-0002-7554-2520, Feschotte, C. and Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384
Viruses 12
(11): 1303.
13 November 2020
Targeting CD33 in chemoresistant AML patient-derived xenografts by CAR-CIK cells modified with an improved SB transposon system.
Rotiroti, M.C. ORCID: https://orcid.org/0000-0002-3214-1540, Buracchi, C., Arcangeli, S., Galimberti, S., Valsecchi, M.G., Perriello, V.M., Rasko, T., Alberti, G., Magnani, C.F., Cappuzzello, C., Lundberg, F., Pande, A. ORCID: https://orcid.org/0009-0008-0826-973X, Dastoli, G., Introna, M., Serafini, M., Biagi, E., Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Biondi, A. and Tettamanti, S.
Molecular Therapy 28
(9): 1974-1986.
2 September 2020
Curative in vivo hematopoietic stem cell gene therapy of murine thalassemia using large regulatory elements.
Wang, H., Georgakopoulou, A., Li, C., Liu, Z., Gil, S., Bashyam, A., Yannaki, E., Anagnostopoulos, A., Pande, A. ORCID: https://orcid.org/0009-0008-0826-973X, Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Papayannopoulou, T. and Lieber, A.
JCI Insight 5
(16): e139538.
20 August 2020
Nuclear inclusions of pathogenic ataxin-1 induce oxidative stress and perturb the protein synthesis machinery.
Laidou, S., Alanis-Lobato, G., Pribyl, J., Raskó, T. ORCID: https://orcid.org/0000-0001-5351-613X, Tichy, B., Mikulasek, K., Tsagiopoulou, M., Oppelt, J., Kastrinaki, G., Lefaki, M., Singh, M. ORCID: https://orcid.org/0000-0002-8626-5418, Zink, A. ORCID: https://orcid.org/0000-0002-8489-6339, Chondrogianni, N., Psomopoulos, F., Prigione, A. ORCID: https://orcid.org/0000-0001-9457-1952, Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Pospisilova, S., Skladal, P., Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Andrade-Navarro, M.A. and Petrakis, S.
Redox Biology 32
: 101458.
May 2020
Human endogenous retrovirus HERV-K(HML-2) RNA causes neurodegeneration through Toll-like receptors.
Dembny, P., Newman, A.G. ORCID: https://orcid.org/0000-0002-0222-9162, Singh, M. ORCID: https://orcid.org/0000-0002-8626-5418, Hinz, M. ORCID: https://orcid.org/0000-0003-2611-4121, Szczepek, M., Krüger, C., Adalbert, R., Dzaye, O., Trimbuch, T. ORCID: https://orcid.org/0000-0001-7512-8955, Wallach, T., Kleinau, G., Derkow, K., Richard, B.C., Schipke, C. ORCID: https://orcid.org/0000-0002-1105-1853, Scheidereit, C. ORCID: https://orcid.org/0000-0002-0446-6129, Stachelscheid, H., Golenbock, D., Peters, O. ORCID: https://orcid.org/0000-0003-0568-2998, Coleman, M., Heppner, F.L., Scheerer, P., Tarabykin, V., Ruprecht, K., Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Mayer, J. and Lehnardt, S.
JCI Insight 5
(7): e131093.
9 April 2020
Loss of Piccolo function in rats induces cerebellar network dysfunction and Pontocerebellar Hypoplasia type 3-like phenotypes.
Falck, J., Bruns, C., Hoffmann-Conaway, S., Straub, I., Plautz, E.J., Orlando, M., Munawar, H., Rivalan, M. ORCID: https://orcid.org/0000-0002-1642-7522, Winter, Y., Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Schmitz, D. ORCID: https://orcid.org/0000-0003-2741-5241, Hamra, F.K., Hallermann, S., Curtis Garner, C. and Ackermann, F.
Journal of Neuroscience 40
(14): 2943-2959.
1 April 2020
Mutant screen for reproduction unveils depression-associated Piccolo’s control over reproductive behavior.
Medrano, G.A., Singh, M. ORCID: https://orcid.org/0000-0002-8626-5418, Plautz, E.J., Good, L.B., Chapman, K.M., Chaudhary, J., Jaichander, P., Powell, H.M., Pudasaini, A., Shelton, J.M., Richardson, J.A., Xie, X.J., Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Braun, C., Ackermann, F., Garner, C.C., Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384 and Hamra, F.K.
bioRxiv
: 405985v3.
19 March 2020
A single amino acid switch converts the sleeping beauty transposase into an efficient unidirectional excisionase with utility in stem cell reprogramming.
Kesselring, L., Miskey, C. ORCID: https://orcid.org/0000-0002-7566-9556, Zuliani, C. ORCID: https://orcid.org/0000-0001-6026-7207, Querques, I., Kapitonov, V., Laukó, A., Fehér, A., Palazzo, A., Diem, T., Lustig, J., Sebe, A., Wang, Y., Dinnyés, A., Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Barabas, O. ORCID: https://orcid.org/0000-0002-2873-5872 and Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658
Nucleic Acids Research 48
(1): 316-331.
1 January 2020
2019
Preclinical evaluation of a cell-based gene therapy using the Sleeping Beauty transposon system in choroidal neovascularization.
Hernandez, M., Recalde, S., Garcia-Garcia, L., Bezunartea, J., Miskey, C. ORCID: https://orcid.org/0000-0002-7566-9556, Johnen, S., Diarra, S., Sebe, A., Rodriguez-Madoz, J.R., Pouillot, S., Marie, C., Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Scherman, D., Kropp, M., Prosper, F., Thumann, G., Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Garcia-Layana, A. and Fernandez-Robredo, P.
Molecular Therapy - Methods and Clinical Development 15
: 403-417.
13 December 2019
Critical role for piccolo in synaptic vesicle retrieval.
Ackermann, F. ORCID: https://orcid.org/0000-0003-3037-8672, Schink, K.O. ORCID: https://orcid.org/0000-0002-5903-4059, Bruns, C., Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Hamra, F.K., Rosenmund, C. ORCID: https://orcid.org/0000-0002-3905-2444 and Garner, C.C.
eLife 8
: e46629.
10 May 2019
A multiple Piccolino-RIBEYE interaction supports plate-shaped synaptic ribbons in retinal neurons.
Müller, T.M., Gierke, K., Joachimsthaler, A., Sticht, H., Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Hamra, F.K., Fejtová, A., Ackermann, F., Garner, C.C., Kremers, J., Brandstätter, J.H. and Regus-Leidig, H.
Journal of Neuroscience 39
(14): 2606-2619.
3 April 2019
In vivo hematopoietic stem cell gene therapy ameliorates murine thalassemia intermedia.
Wang, H., Georgakopoulou, A., Psatha, N., Li, C., Capsali, C., Samal, H.B., Anagnostopoulos, A., Ehrhardt, A., Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Papayannopoulou, T., Yannaki, E. and Lieber, A.
Journal of Clinical Investigation 129
(2): 598-615.
1 February 2019
2018
The genetic ancestry of modern Indus Valley populations from Northwest India.
Pathak, A.K., Kadian, A., Kushniarevich, A., Montinaro, F., Mondal, M., Ongaro, L., Singh, M. ORCID: https://orcid.org/0000-0002-8626-5418, Kumar, P., Rai, N., Parik, J., Metspalu, E., Rootsi, S., Pagani, L., Kivisild, T., Metspalu, M., Chaubey, G. and Villems, R.
American Journal of Human Genetics 103
(6): 918-929.
6 December 2018
Ten things you should know about transposable elements.
Bourque, G. ORCID: https://orcid.org/0000-0002-3933-9656, Burns, K.H., Gehring, M., Gorbunova, V., Seluanov, A., Hammell, M., Imbeault, M., Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Levin, H.L., Macfarlan, T.S., Mager, D.L. and Feschotte, C.
Genome Biology 19
(1): 199.
19 November 2018
Improved molecular platform for the gene therapy of rare diseases by liver protein secretion.
Quiviger, M., Giannakopoulos, A., Verhenne, S., Marie, C., Stavrou, E.F., Vanhoorelbeke, K., Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, De Meyer, S.F., Athanassiadou, A. and Scherman, D.
European Journal of Medical Genetics 61
(11): 723-728.
November 2018
A simple approach for multi-targeted shRNA-mediated inducible knockdowns using Sleeping Beauty vectors.
Fink, S. ORCID: https://orcid.org/0000-0002-4016-0274, Zugelder, L., Roth, B., Brandt, E., Meloche, S., Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Bargou, R.C. and Stühmer, T. ORCID: https://orcid.org/0000-0001-5544-3018
PLoS ONE 13
(10): e0205585.
19 October 2018
Genome engineering using Sleeping Beauty transposition in vertebrates.
Chilkunda, S.S., Raghunathan, V., Narayanavari, S.A. ORCID: https://orcid.org/0000-0002-6997-4829, Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658 and Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384
In:
Genome editing and engineering.
Cambridge University Press, Cambridge, 249-269.
ISBN 9781316756300
July 2018
Integrating HDAd5/35++ vectors as a new platform for HSC gene therapy of hemoglobinopathies.
Li, C., Psatha, N., Wang, H., Singh, M. ORCID: https://orcid.org/0000-0002-8626-5418, Samal, H.B., Zhang, W., Ehrhardt, A., Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Papayannopoulou, T. and Lieber, A.
Molecular Therapy - Methods and Clinical Development 9
: 142-152.
15 June 2018
The antibiotic-free pFAR4 vector paired with the sleeping beauty transposon sSystem mediates efficient transgene delivery in human cells.
Pastor, M., Johnen, S., Harmening, N., Quiviger, M., Pailloux, J., Kropp, M., Walter, P., Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Thumann, G., Scherman, D. and Marie, C.
Molecular Therapy - Nucleic Acids 11
: 57-67.
1 June 2018
Efficient non-viral T cell engineering by Sleeping Beauty minicircles diminishing DNA toxicity and miRNAs silencing the endogenous TCR.
Clauss, J. ORCID: https://orcid.org/0000-0001-6783-1536, Obenaus, M. ORCID: https://orcid.org/0000-0002-5090-9162, Miskey, C. ORCID: https://orcid.org/0000-0002-7566-9556, Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Uckert, W. and Bunse, M. ORCID: https://orcid.org/0000-0002-7554-2520
Human Gene Therapy 29
(5): 569-584.
May 2018
Efficient non-viral gene delivery into human hematopoietic stem cells by minicircle Sleeping Beauty transposon vectors.
Holstein, M., Mesa-Nuñez, C., Miskey, C. ORCID: https://orcid.org/0000-0002-7566-9556, Almarza, E., Poletti, V., Schmeer, M., Grueso, E., Ordóñez Flores, J.C., Kobelt, D. ORCID: https://orcid.org/0000-0002-9373-0648, Walther, W. ORCID: https://orcid.org/0000-0003-2884-0231, Aneja, M.K., Geiger, J,, Bonig, H.B., Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Schleef, M., Rudolph, C., Mavilio, F., Bueren, J.A., Guenechea, G. and Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658
Molecular Therapy 26
(4): 1137-1153.
4 April 2018
A combined in vivo HSC transduction/selection approach results in efficient and stable gene expression in peripheral blood cells in mice.
Wang, H., Richter, M., Psatha, N., Li, C., Kim, J., Liu, J., Ehrhardt, A., Nilsson, S.K., Cao, B., Palmer, D., Ng, P., Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Haworth, K.G., Kiem, H.P., Papayannopoulou, T. and Lieber, A.
Molecular Therapy - Methods and Clinical Development 8
: 52-64.
16 March 2018
High and long-term von Willebrand factor expression after Sleeping Beauty transposon-mediated gene therapy in a mouse model of severe von Willebrand disease.
Portier, I., Vanhoorelbeke, K., Verhenne, S., Pareyn, I., Vandeputte, N., Deckmyn, H., Goldenberg, D.S., Samal, H.B., Singh, M. ORCID: https://orcid.org/0000-0002-8626-5418, Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384 and De Meyer, S.F.
Journal of Thrombosis and Haemostasis 16
(3): 592-604.
March 2018
2017
Long-term PEDF release in rat iris and retinal epithelial cells after Sleeping Beauty transposon-mediated gene delivery.
Garcia-Garcia, L., Recalde, S., Hernandez, M., Bezunartea, J., Rodriguez-Madoz, J.R., Johnen, S., Diarra, S., Marie, C., Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Scherman, D., Kropp, M., Thumann, G., Prosper, F., Fernandez-Robredo, P. and Garcia-Layana, A.
Molecular Therapy - Nucleic Acids 9
: 1-11.
15 December 2017
Disturbed placental imprinting in preeclampsia leads to altered expression of DLX5, a human-specific early trophoblast marker.
Zadora, J. ORCID: https://orcid.org/0000-0002-6906-7815, Singh, M. ORCID: https://orcid.org/0000-0002-8626-5418, Herse, F. ORCID: https://orcid.org/0000-0002-9305-8134, Przybyl, L. ORCID: https://orcid.org/0000-0001-9777-8879, Haase, N. ORCID: https://orcid.org/0000-0003-0727-1738, Golic, M. ORCID: https://orcid.org/0000-0003-3030-2678, Yung, H.W., Huppertz, B., Cartwright, J.E., Whitley, G.S., Johnsen, G.M., Levi, G., Isbruch, A., Schulz, H. ORCID: https://orcid.org/0000-0002-0226-964X, Luft, F.C. ORCID: https://orcid.org/0000-0002-8635-1199, Müller, D.N. ORCID: https://orcid.org/0000-0003-3650-5644, Staff, A.C., Hurst, L.D., Dechend, R. ORCID: https://orcid.org/0000-0001-6636-3080 and Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384
Circulation 136
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7 November 2017
Gene therapy with the Sleeping Beauty transposon system.
Kebriaei, P., Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Narayanavari, S.A. ORCID: https://orcid.org/0000-0002-6997-4829, Singh, H. and Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658
Trends in Genetics 33
(11): 852-870.
November 2017
Wide awake and ready to move: 20 years of non-viral therapeutic genome engineering with the Sleeping Beauty transposon system.
Hodge, R., Narayanavari, S. ORCID: https://orcid.org/0000-0002-6997-4829, Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384 and Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658
Human Gene Therapy 28
(10): 842-855.
1 October 2017
Generation of an immortalized mesenchymal stem cell line producing a secreted biosensor protein for glucose monitoring.
Siska, E.K. ORCID: https://orcid.org/0000-0001-5861-9891, Weisman, I., Romano, J., Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Barkai, U., Petrakis, S. and Koliakos, G.
PLoS ONE 12
(9): e0185498.
26 September 2017
Going non-viral: the Sleeping Beauty transposon system breaks on through to the clinical side.
Hudecek, M., Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Johnen, S., Renner, M., Thumann, G. and Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658
Critical Reviews in Biochemistry and Molecular Biology 52
(4): 355-380.
August 2017
How to tame an endogenous retrovirus: HERVH and the evolution of human pluripotency.
Römer, C., Singh, M. ORCID: https://orcid.org/0000-0002-8626-5418, Hurst, L.D. and Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384
Current Opinion in Virology 25
: 49-58.
August 2017
Downregulation of Plzf gene ameliorates metabolic and cardiac traits in the spontaneously hypertensive rat.
Liška, F., Landa, V., Zidek, V., Mlejnek, P., Šilhavý, J., Šimáková, M., Strnad, H., Trnovská, J., Škop, V., Kazdová, L., Starker, C.G., Voytas, D.F., Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Mancini, M., Šeda, O., Křen, V. and Pravenec, M. ORCID: https://orcid.org/0000-0001-9197-5871
Hypertension 69
(6): 1084-1091.
June 2017
Placental DAPK1 and autophagy marker LC3B-II are dysregulated by TNF-α in a gestational age-dependent manner.
Prokesch, A., Blaschitz, A., Bauer, T., Moser, G., Hiden, U., Zadora, J. ORCID: https://orcid.org/0000-0002-6906-7815, Dechend, R. ORCID: https://orcid.org/0000-0001-6636-3080, Herse, F. ORCID: https://orcid.org/0000-0002-9305-8134 and Gauster, M. ORCID: https://orcid.org/0000-0003-0386-6857
Histochemistry and Cell Biology 147
(6): 695-705.
June 2017
Human iPSC-derived neural progenitors are an effective drug discovery model for neurological mtDNA disorders.
Lorenz, C. ORCID: https://orcid.org/0000-0002-7762-8133, Lesimple, P. ORCID: https://orcid.org/0000-0001-9754-6103, Bukowiecki, R., Zink, A. ORCID: https://orcid.org/0000-0002-8489-6339, Inak, G., Mlody, B. ORCID: https://orcid.org/0000-0001-5184-1772, Singh, M. ORCID: https://orcid.org/0000-0002-8626-5418, Semtner, M. ORCID: https://orcid.org/0000-0001-9379-9023, Mah, N. ORCID: https://orcid.org/0000-0002-1240-8076, Auré, K., Leong, M., Zabiegalov, O., Lyras, E.M. ORCID: https://orcid.org/0000-0003-3269-0854, Pfiffer, V., Fauler, B., Eichhorst, J., Wiesner, B., Huebner, N. ORCID: https://orcid.org/0000-0002-1218-6223, Priller, J. ORCID: https://orcid.org/0000-0001-7596-0979, Mielke, T., Meierhofer, D. ORCID: https://orcid.org/0000-0002-0170-868X, Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Meier, J.C. ORCID: https://orcid.org/0000-0001-5574-3336, Bouillaud, F. ORCID: https://orcid.org/0000-0002-7518-9237, Adjaye, J., Schuelke, M. ORCID: https://orcid.org/0000-0003-2824-3891, Wanker, E.E. ORCID: https://orcid.org/0000-0001-8072-1630, Lombès, A. ORCID: https://orcid.org/0000-0002-9064-0399 and Prigione, A. ORCID: https://orcid.org/0000-0001-9457-1952
Cell Stem Cell 20
(5): 659-674.e9.
4 May 2017
Long-term prevention of congenital thrombotic thrombocytopenic purpura in ADAMTS13 knockout mice by sleeping beauty transposon-mediated gene therapy.
Verhenne, S., Vandeputte, N., Pareyn, I., Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Rottensteiner, H., Deckmyn, H., De Meyer, S.F. and Vanhoorelbeke, K.
Arteriosclerosis Thrombosis and Vascular Biology 37
(5): 836-844.
May 2017
Localized irradiation of mouse legs using an image-guided robotic linear accelerator.
Kufeld, M., Escobar, H. ORCID: https://orcid.org/0000-0002-8128-7845, Marg, A. ORCID: https://orcid.org/0000-0003-3673-4244, Pasemann, D., Budach, V. and Spuler, S. ORCID: https://orcid.org/0000-0002-0155-1117
Annals of Translational Medicine 5
(7): 156.
April 2017
Transposition of the bamboo Mariner-like element Ppmar1 in yeast.
Zhou, M.B., Hu, H., Miskey, C. ORCID: https://orcid.org/0000-0002-7566-9556, Lazarow, K., Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Kunze, R., Yang, G., Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384 and Tang, D.Q.
Molecular Phylogenetics and Evolution 109
: 367-374.
April 2017
Sleeping Beauty transposon vectors for therapeutic applications: advances and challenges.
Narayanavari, S.A. ORCID: https://orcid.org/0000-0002-6997-4829 and Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384
Cell and Gene Therapy Insights 3
(2): 131-158.
30 March 2017
Engineering of PEDF-expressing primary pigment epithelial cells by the SB transposon system delivered by pFAR4 plasmids.
Thumann, G., Harmening, N., Prat-Souteyrand, C., Marie, C., Pastor, M., Sebe, A., Miskey, C. ORCID: https://orcid.org/0000-0002-7566-9556, Hurst, L., Diarra, S., Kropp, M., Walter, P., Scherman, D., Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384 and Johnen, S.
Molecular Therapy - Nucleic Acids 6
: 302-314.
17 March 2017
Transposase.
Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384 and Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658
In:
Reference Module in Life Sciences.
Elsevier, 161-164.
ISBN 978-0-12-809633-8
16 March 2017
Regulated complex assembly safeguards the fidelity of Sleeping Beauty transposition.
Wang, Y. ORCID: https://orcid.org/0000-0001-8269-5296, Pryputniewicz-Dobrinska, D., Nagy, E.E., Kaufman, C.D. ORCID: https://orcid.org/0009-0001-9888-7740, Singh, M. ORCID: https://orcid.org/0000-0002-8626-5418, Yant, S., Wang, J. ORCID: https://orcid.org/0000-0002-7027-0298, Dalda, A., Kay, M.A., Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658 and Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384
Nucleic Acids Research 45
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9 January 2017
Sleeping Beauty transposition: from biology to applications.
Narayanavari, S.A., Chilkunda, S.S., Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658 and Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384
Critical Reviews in Biochemistry and Molecular Biology 52
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2016
In vivo transduction of primitive mobilized hematopoietic stem cells after intravenous injection of integrating adenovirus vectors.
Richter, M., Saydaminova, K., Yumul, R., Krishnan, R., Liu, J., Nagy, E.E., Singh, M. ORCID: https://orcid.org/0000-0002-8626-5418, Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Cattaneo, R., Uckert, W., Palmer, D., Ng, P., Haworth, K.G., Kiem, H.P., Ehrhardt, A., Papayannopoulou, T. and Lieber, A.
Blood 128
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3 November 2016
Targeting of the Plzf gene in the rat by transcription activator-like effector nuclease results in caudal regression syndrome in spontaneously hypertensive rats.
Liška, F., Peterková, R., Peterka, M., Landa, V., Zidek, V., Mlejnek, P., Šilhavý, J., Šimáková, M., Křen, V., Starker, C.G., Voytas, D.F., Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384 and Pravenec, M. ORCID: https://orcid.org/0000-0001-9197-5871
PLoS ONE 11
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11 October 2016
Structural determinants of sleeping beauty transposase activity.
Abrusán, G., Yant, S.R., Szilágyi, A., Marsh, J.A., Mátés, L., Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Barabás, O. and Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658
Molecular Therapy 24
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August 2016
Sleeping Beauty transposase structure allows rational design of hyperactive variants for genetic engineering.
Voigt, F., Wiedemann, L., Zuliani, C., Querques, I., Sebe, A., Mátés, L. ORCID: https://orcid.org/0000-0002-0058-470X, Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658 and Barabas, O.
Nature Communications 7
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30 March 2016
A Helitron transposon reconstructed from bats reveals a novel mechanism of genome shuffling in eukaryotes.
Grabundzija, I., Messing, S.A., Thomas, J., Cosby, R.L., Bilic, I. ORCID: https://orcid.org/0000-0002-2730-1634, Miskey, C. ORCID: https://orcid.org/0000-0002-7566-9556, Gogol-Döring, A. ORCID: https://orcid.org/0009-0001-7697-0551, Kapitonov, V., Diem, T., Dalda, A., Jurka, J., Pritham, E.J., Dyda, F., Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384 and Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658
Nature Communications 7
: 10716.
2 March 2016
Generation of human induced pluripotent stem cell line from a patient with a long QT syndrome type 2.
Fatima, A., Ivanyuk, D., Herms, S., Heilmann-Heimbach, S., O'Shea, O., Chapman, C., Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Farr, M., Hescheler, J. and Šarić, T.
Stem Cell Research 16
(2): 304-307.
March 2016
Genome-wide profiling reveals remarkable parallels between insertion site selection properties of the MLV retrovirus and the piggyBac transposon in primary human CD4(+) T cells.
Gogol-Döring, A. ORCID: https://orcid.org/0009-0001-7697-0551, Ammar, I., Gupta, S., Bunse, M. ORCID: https://orcid.org/0000-0002-7554-2520, Miskey, C. ORCID: https://orcid.org/0000-0002-7566-9556, Chen, W. ORCID: https://orcid.org/0000-0003-3263-1627, Uckert, W., Schulz, T.F., Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384 and Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658
Molecular Therapy 24
(3): 592-606.
March 2016
Sleeping Beauty transposon vectors in liver directed gene delivery of LDLR and VLDLR for gene therapy of familial hypercholesterolemia.
Turunen, T.A.K., Kurkipuro, J., Heikura, T., Vuorio, T., Hytönen, E., Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384 and Ylä-Herttuala, S.
Molecular Therapy 24
(3): 620-635.
March 2016
Identification and re-addressing of a transcriptionally permissive locus in the porcine genome.
Garrels, W., Mukherjee, A., Holler, S., Cleve, N., Talluri, T.R., Barg-Kues, B., Diederich, M., Köhler, P., Petersen, B., Lucas-Hahn, A., Niemann, H., Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658 and Kues, W.A.
Transgenic Research 25
(1): 63-70.
February 2016
Isolation and cultivation of naive-like human pluripotent stem cells based on HERVH expression.
Wang, J. ORCID: https://orcid.org/0000-0002-7027-0298, Singh, M., Sun, C., Besser, D. ORCID: https://orcid.org/0000-0002-4958-9624, Prigione, A. ORCID: https://orcid.org/0000-0001-9457-1952, Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Hurst, L.D. and Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384
Nature Protocols 11
(2): 327-346.
February 2016
Full-length dysferlin transfer by the hyperactive Sleeping Beauty transposase restores dysferlin-deficient muscle.
Escobar, H. ORCID: https://orcid.org/0000-0002-8128-7845, Schöwel, V., Spuler, S. ORCID: https://orcid.org/0000-0002-0155-1117, Marg, A. ORCID: https://orcid.org/0000-0003-3673-4244 and Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384
Molecular Therapy - Nucleic Acids 5
: e277.
19 January 2016
Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells.
Klawitter, S., Fuchs, N.V. ORCID: https://orcid.org/0000-0003-4175-0740, Upton, K.R., Muñoz-Lopez, M., Shukla, R., Wang, J. ORCID: https://orcid.org/0000-0002-7027-0298, Garcia-Cañadas, M., Lopez-Ruiz, C., Gerhardt, D.J., Sebe, A., Grabundzija, I., Merkert, S., Gerdes, P., Pulgarin, J.A., Bock, A., Held, U., Witthuhn, A., Haase, A., Sarkadi, B., Löwer, J., Wolvetang, E.J., Martin, U., Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Garcia-Perez, J.L., Faulkner, G.J. and Schumann, G.G.
Nature Communications 7
: 10286.
8 January 2016
Pluripotency and the endogenous retrovirus HERVH: Conflict or serendipity?
Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Wang, J. ORCID: https://orcid.org/0000-0002-7027-0298, Singh, M. ORCID: https://orcid.org/0000-0002-8626-5418, Mager, D.L. and Hurst, L.D.
BioEssays 38
(1): 109-117.
January 2016
2015
Retrotransposition creates sloping shores: a graded influence of hypomethylated CpG islands on flanking CpG sites.
Grandi, F.C., Rosser, J.M., Newkirk, S.J., Yin, J., Jiang, X., Xing, Z., Whitmore, L., Bashir, S. ORCID: https://orcid.org/0000-0002-1281-8710, Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Ye, P., Yu, Y.E. and An, W.
Genome Research 25
(8): 1135-1146.
August 2015
Transposon-based, targeted ex vivo gene therapy to treat age-related macular degeneration (TargetAMD).
Thumann, G., Perdikomati-Dahmen, M., Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Garcia Layana, A., Ronchetti, M., Petrovski, G., Scherman, D., Aranda, P., Pouillot, S., Binder, S., Johnen, S. and van den Berg, J.
Human Gene Therapy Clinical Development 26
(2): 97-100.
18 June 2015
Sleeping Beauty transposition.
Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658 and Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384
Microbiology Spectrum 3
(2)
April 2015
Antiangiogenic and neurogenic activities of Sleeping Beauty-mediated PEDF-transfected RPE cells in vitro and in vivo.
Johnen, S., Djalali-Talab, Y., Kazanskaya, O., Möller, T., Harmening, N., Kropp, M., Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Walter, P. and Thumann, G.
BioMed Research International 2015
: 863845.
2015
Sleeping Beauty transposition.
Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658 and Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384
In:
Mobile DNA III.
ASM Press, Washington, DC, 851-872.
ISBN 9781555819200
2015
2014
Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells.
Wang, J. ORCID: https://orcid.org/0000-0002-7027-0298, Xie, G. ORCID: https://orcid.org/0000-0002-8286-2987, Singh, M. ORCID: https://orcid.org/0000-0002-8626-5418, Ghanbarian, A.T., Raskó, T., Szvetnik, A., Cai, H., Besser, D. ORCID: https://orcid.org/0000-0002-4958-9624, Prigione, A. ORCID: https://orcid.org/0000-0001-9457-1952, Fuchs, N.V. ORCID: https://orcid.org/0000-0003-4175-0740, Schumann, G.G., Chen, W. ORCID: https://orcid.org/0000-0003-3263-1627, Lorincz, M.C., Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Hurst, L.D. and Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384
Nature 516
(7531): 405-409.
18 December 2014
Genomic analysis of Sleeping Beauty transposon integration in human somatic cells.
Turchiano, G., Latella, M.C., Gogol-Döring, A. ORCID: https://orcid.org/0009-0001-7697-0551, Cattoglio, C., Mavilio, F., Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658 and Recchia, A.
PLoS ONE 9
(11): e112712.
12 November 2014
Human satellite cells have regenerative capacity and are genetically manipulable.
Marg, A. ORCID: https://orcid.org/0000-0003-3673-4244, Escobar, H. ORCID: https://orcid.org/0000-0002-8128-7845, Gloy, S., Kufeld, M., Zacher, J., Spuler, A., Birchmeier, C. ORCID: https://orcid.org/0000-0002-2041-8872, Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384 and Spuler, S. ORCID: https://orcid.org/0000-0002-0155-1117
Journal of Clinical Investigation 124
(10): 4257-4265.
1 October 2014
Gibbon genome and the fast karyotype evolution of small apes.
Carbone, L., Harris, R.A., Gnerre, S., Veeramah, K.R., Lorente-Galdos, B., Huddleston, J., Meyer, T.J., Herrero, J., Roos, C., Aken, B., Anaclerio, F., Archidiacono, N., Baker, C., Barrell, D., Batzer, M.A., Beal, K., Blancher, A., Bohrson, C.L., Brameier, M., Campbell, M.S., Capozzi, O., Casola, C., Chiatante, G., Cree, A., Damert, A., de Jong, P.J., Dumas, L., Fernandez-Callejo, M., Flicek, P., Fuchs, N.V. ORCID: https://orcid.org/0000-0003-4175-0740, Gut, I., Gut, M., Hahn, M.W., Hernandez-Rodriguez, J., Hillier, L.W., Hubley, R., Ianc, B., Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Jablonski, N.G., Johnstone, L.M., Karimpour-Fard, A., Konkel, M.K., Kostka, D., Lazar, N.H., Lee, S.L., Lewis, L.R., Liu, Y., Locke, D.P., Mallick, S., Mendez, F.L., Muffato, M., Nazareth, L.V., Nevonen, K.A., O'Bleness, M., Ochis, C., Odom, D.T., Pollard, K.S., Quilez, J., Reich, D., Rocchi, M., Schumann, G.G., Searle, S., Sikela, J.M., Skollar, G., Smit, A., Sonmez, K., ten Hallers, B., Terhune, E., Thomas, G.W.C., Ullmer, B., Ventura, M., Walker, J.A., Wall, J.D., Walter, L., Ward, M.C., Wheelan, S.J., Whelan, C.W., White, S., Wilhelm, L.J., Woerner, A.E., Yandell, M., Zhu, B., Hammer, M.F., Marques-Bonet, T., Eichler, E.E., Fulton, L., Fronick, C., Muzny, D.M., Warren, W.C., Worley, K.C., Rogers, J., Wilson, R.K. and Gibbs, R.A.
Nature 513
(7517): 195-201.
11 September 2014
Human somatic cell mutagenesis creates genetically tractable sarcomas.
Molyneux, S.D., Waterhouse, P.D., Shelton, D., Shao, Y.W., Watling, C.M., Tang, Q.L., Harris, I.S., Dickson, B.C., Tharmapalan, P., Sandve, G.K., Zhang, X., Bailey, S.D., Berman, H., Wunder, J.S., Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Lupien, M., Mak, T.W. and Khokha, R.
Nature Genetics 46
(9): 964-972.
September 2014
Excision efficiency is not strongly coupled to transgenic rate: cell type dependent transposition efficiency of Sleeping Beauty and piggyBac DNA transposons.
Kolacsek, O., Erdei, Z., Apáti, A., Sándor, S., Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Sarkadi, B. and Orbán, T.I.
Human Gene Therapy Methods 25
(4): 241-252.
August 2014
Germline transgenesis in pigs by cytoplasmic microinjection of Sleeping Beauty transposons.
Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Garrels, W., Mátés, L., Yau, T.Y., Bashir, S. ORCID: https://orcid.org/0000-0002-1281-8710, Zidek, V., Landa, V., Geurts, A., Pravenec, M. ORCID: https://orcid.org/0000-0001-9197-5871, Rülicke, T., Kues, W.A. and Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384
Nature Protocols 9
(4): 810-827.
April 2014
Germline transgenesis in rabbits by pronuclear microinjection of Sleeping Beauty transposons.
Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Hiripi, L., Hoffmann, O.I., Mátés, L., Yau, T.Y., Bashir, S. ORCID: https://orcid.org/0000-0002-1281-8710, Zidek, V., Landa, V., Geurts, A., Pravenec, M. ORCID: https://orcid.org/0000-0001-9197-5871, Rülicke, T., Bösze, Z. and Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384
Nature Protocols 9
(4): 794-809.
April 2014
Germline transgenesis in rodents by pronuclear microinjection of Sleeping Beauty transposons.
Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Mátés, L., Yau, T.Y., Landa, V., Zidek, V., Bashir, S. ORCID: https://orcid.org/0000-0002-1281-8710, Hoffmann, O.I., Hiripi, L., Garrels, W., Kues, W.A., Boesze, Z., Geurts, A., Pravenec, M. ORCID: https://orcid.org/0000-0001-9197-5871, Rülicke, T. and Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384
Nature Protocols 9
(4): 773-793.
April 2014
Suicidal autointegration of Sleeping Beauty and piggyBac transposons in eukaryotic cells.
Wang, Y. ORCID: https://orcid.org/0000-0001-8269-5296, Wang, J. ORCID: https://orcid.org/0000-0002-7027-0298, Devaraj, A. ORCID: https://orcid.org/0000-0002-8685-6728, Singh, M. ORCID: https://orcid.org/0000-0002-8626-5418, Jimenez Orgaz, A., Chen, J.X. ORCID: https://orcid.org/0000-0002-3671-553X, Selbach, M. ORCID: https://orcid.org/0000-0003-2454-8751, Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658 and Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384
PLoS Genetics 10
(3): e1004103.
13 March 2014
2013
Human endogenous retrovirus K (HML-2) RNA and protein expression is a marker for human embryonic and induced pluripotent stem cells.
Fuchs, N.V. ORCID: https://orcid.org/0000-0003-4175-0740, Loewer, S., Daley, G.Q., Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Löwer, J. and Löwer, R.
Retrovirology 10
(1): 115.
24 October 2013
Hybrid adeno-associated viral vectors utilizing transposase-mediated somatic integration for stable transgene expression in human cells.
Zhang, W., Solanki, M., Müther, N., Ebel, M., Wang, J. ORCID: https://orcid.org/0000-0002-7027-0298, Sun, C., Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384 and Ehrhardt, A.
PLoS ONE 8
(10): e76771.
8 October 2013
Integration profile and safety of an adenovirus hybrid-vector utilizing hyperactive Sleeping Beauty transposase for somatic integration.
Zhang, W., Muck-Hausl, M., Wang, J. ORCID: https://orcid.org/0000-0002-7027-0298, Sun, C., Gebbing, M., Miskey, C. ORCID: https://orcid.org/0000-0002-7566-9556, Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384 and Ehrhardt, A.
PLoS ONE 8
(10): e75344.
4 October 2013
Impaired cell reprogramming in non-homologous end joining deficient cells.
Molina-Estevez, F.J., Lozano, M.L., Navarro, S., Torres, Y., Grabundzija, I., Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Samper, E., Bueren, J.A. and Guenechea, G.
Stem Cells 31
(8): 1726-1730.
August 2013
Regulation of DNA transposition by CpG methylation and chromatin structure in human cells.
Jursch, T., Miskey, C. ORCID: https://orcid.org/0000-0002-7566-9556, Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384 and Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658
Mobile DNA 4
(1): 15.
15 May 2013
Transposase.
Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Grzela, D. ORCID: https://orcid.org/0000-0002-0667-6488 and Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658
In:
Brenner's Encyclopedia of Genetics, Second Edition.
Elsevier / Academic Press, London, 161-164.
ISBN 978-0-12-374984-0
May 2013
Cell division promotes efficient retrotransposition in a stable L1 reporter cell line.
Xie, Y., Mates, L. ORCID: https://orcid.org/0000-0002-0058-470X, Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Martin, S.L. and An, W.
Mobile DNA 4
(1): 1-10.
6 March 2013
Transposon-mediated transgenesis, transgenic rescue, and tissue-specific gene expression in rodents and rabbits.
Katter, K., Geurts, A.M., Hoffmann, O., Mátés, L., Landa, V., Hiripi, L., Moreno, C., Lazar, J., Bashir, S. ORCID: https://orcid.org/0000-0002-1281-8710, Zidek, V., Popova, E. ORCID: https://orcid.org/0000-0002-3043-9650, Jerchow, B. ORCID: https://orcid.org/0000-0002-7031-8730, Becker, K., Devaraj, A. ORCID: https://orcid.org/0000-0002-8685-6728, Walter, I., Grzybowksi, M., Corbett, M., Filho, A.R., Hodges, M.R., Bader, M. ORCID: https://orcid.org/0000-0003-4780-4164, Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Jacob, H.J., Pravenec, M. ORCID: https://orcid.org/0000-0001-9197-5871, Bosze, Z., Rülicke, T. and Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384
FASEB Journal 27
(3): 930-941.
March 2013
Sleeping Beauty transposon-based system for cellular reprogramming and targeted gene insertion in induced pluripotent stem cells.
Grabundzija, I., Wang, J. ORCID: https://orcid.org/0000-0002-7027-0298, Sebe, A., Erdei, Z., Kajdi, R., Devaraj, A. ORCID: https://orcid.org/0000-0002-8685-6728, Steinemann, D., Szuhai, K., Stein, U. ORCID: https://orcid.org/0000-0001-7006-282X, Cantz, T., Schambach, A., Baum, C., Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Sarkadi, B. and Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658
Nucleic Acids Research 41
(3): 1829-1847.
1 February 2013
Derivation and characterization of Sleeping Beauty transposon-mediated porcine induced pluripotent stem cells.
Kues, W.A., Herrmann, D., Barg-Kues, B., Meena Haridoss, S., Nowak-Imialek, M., Buchholz, T., Streeck, M., Grebe, A., Grabundzija, I., Merkert, S., Martin, U., Hall, V.J., Rasmussen, M.A., Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Maddox-Hyttel, P. and Niemann, H.
Stem Cells and Development 22
(1): 124-135.
1 January 2013
Germline transgenesis of the chordate Ciona intestinalis with hyperactive variants of sleeping beauty transposable element.
Hozumi, A., Mita, K., Miskey, C. ORCID: https://orcid.org/0000-0002-7566-9556, Mates, L., Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Satake, H. and Sasakura, Y.
Developmental Dynamics 242
(1): 30-43.
January 2013
2012
Generation of mouse induced pluripotent stem cells from different genetic backgrounds using Sleeping beauty transposon mediated gene transfer.
Muenthaisong, S., Ujhelly, O., Polgar, Z., Varga, E., Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Pirity, M.K. and Dinnyes, A.
Experimental Cell Research 318
(19): 2482-2489.
15 November 2012
A6-5: Sleeping Beauty transposon based gene therapy.
Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384 and Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658
In:
The CliniBook.
EDP Sciences, Île-de-France, France, 284-289.
ISBN 9782842542375
1 November 2012
Retargeting Sleeping Beauty transposon insertions by engineered zinc finger DNA-binding domains.
Voigt, K., Gogol-Doering, A. ORCID: https://orcid.org/0009-0001-7697-0551, Miskey, C. ORCID: https://orcid.org/0000-0002-7566-9556, Chen, W. ORCID: https://orcid.org/0000-0003-3263-1627, Cathomen, T., Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384 and Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658
Molecular Therapy 20
(10): 1852-1862.
October 2012
Retargeting transposon insertions by the adeno-associated virus Rep protein.
Ammar, I., Gogol-Doering, A. ORCID: https://orcid.org/0009-0001-7697-0551, Miskey, C. ORCID: https://orcid.org/0000-0002-7566-9556, Chen, W. ORCID: https://orcid.org/0000-0003-3263-1627, Cathomen, T., Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384 and Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658
Nucleic Acids Research 40
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1 August 2012
Sleeping Beauty transposon-mediated transfection of retinal and iris pigment epithelial cells.
Johnen, S., Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Stocker, M., Harmening, N., Salz, A.K., Walter, P. and Thumann, G.
Investigative Ophthalmology & Visual Science 53
(8): 4787-4796.
18 July 2012
Gateway compatible transposon vector to genetically modify human embryonic kidney and adipose-derived stromal cells.
Petrakis, S., Rasko, T., Mates, L., Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Kouzi-Koliakou, K. and Koliakos, G.
Biotechnology Journal 7
(7): 891-897.
July 2012
The Sleeping Beauty transposon system for clinical applications.
Swierczek, M., Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384 and Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658
Expert Opinion on Biological Therapy 12
(2): 139-153.
February 2012
The sleeping beauty transposon toolbox.
Ammar, I., Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384 and Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658
Methods in Molecular Biology 859
: 229-240.
31 January 2012
2011
Genotype-independent transmission of transgenic fluorophore protein by boar spermatozoa.
Garrels, W., Holler, S., Taylor, U., Herrmann, D., Struckmann, C., Klein, S., Barg-Kues, B., Nowak-Imialek, M., Ehling, C., Rath, D., Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Niemann, H. and Kues, W.A.
PLoS ONE 6
(11): e27563.
16 November 2011
Recombinase technology for gene therapy.
Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658
Current Gene Therapy 11
(5): 331.
1 October 2011
Sleeping Beauty transposon mutagenesis in rat spermatogonial stem cells.
Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Medrano, G., Chapman, K.M. and Hamra, F.K.
Nature Protocols 6
(10): 1521-1535.
October 2011
Avoiding cytotoxicity of transposases by dose-controlled mRNA delivery.
Galla, M., Schambach, A., Falk, C.S., Maetzig, T., Kuehle, J., Lange, K., Zychlinski, D., Heinz, N., Brugman, M.H., Goehring, G., Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658 and Baum, C.
Nucleic Acids Research 39
(16): 7147-7160.
1 September 2011
Nonviral gene delivery with the Sleeping Beauty transposon system.
Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658 and Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384
Human Gene Therapy 22
(9): 1043-1051.
September 2011
The hyperactive Sleeping Beauty transposase SB100X improves the genetic modification of T cells to express a chimeric antigen receptor.
Jin, Z., Maiti, S., Huls, H., Singh, H., Olivares, S., Mates, L. ORCID: https://orcid.org/0000-0002-0058-470X, Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Lee, D.A., Champlin, R.E. and Cooper, L.J.
Gene Therapy 18
(9): 849-856.
September 2011
Germline transgenic pigs by Sleeping Beauty transposition in porcine zygotes and targeted integration in the pig genome.
Garrels, W., Mates, L. ORCID: https://orcid.org/0000-0002-0058-470X, Holler, S., Dalda, A., Taylor, U., Petersen, B., Niemann, H., Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658 and Kues, W.A.
PLoS ONE 6
(8): e23573.
29 August 2011
Comparative genomic integration profiling of Sleeping Beauty transposons mobilized with high efficacy from integrase-defective lentiviral vectors in primary human cells.
Moldt, B., Miskey, C. ORCID: https://orcid.org/0000-0002-7566-9556, Staunstrup, N.H., Gogol-Doering, A. ORCID: https://orcid.org/0009-0001-7697-0551, Bak, R.O., Sharma, N., Mates, L. ORCID: https://orcid.org/0000-0002-0058-470X, Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Chen, W. ORCID: https://orcid.org/0000-0003-3263-1627, Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658 and Mikkelsen, J.G.
Molecular Therapy 19
(8): 1499-1510.
August 2011
Sleeping Beauty transposon mutagenesis of the rat genome in spermatogonial stem cells.
Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Chapman, K.M. and Hamra, F.K.
Methods 53
(4): 356-365.
April 2011
Reliable transgene-independent method for determining Sleeping Beauty transposon copy numbers.
Kolacsek, O., Krizsik, V., Schamberger, A., Erdei, Z., Apati, A., Varady, G., Mates, L. ORCID: https://orcid.org/0000-0002-0058-470X, Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Sarkadi, B. and Orban, T.I.
Mobile DNA 2
(1): 5.
3 March 2011
Transgene Expression durch zytoplasmatische Injektion von Plasmiden und Transposon-basierten Konstrukten in Saeugerembryonen [Transgenetic expression by cytoplasmic injection of plasmids and transposon-based constructs in mammalian embryos].
Garrels, W., Holler, S., Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Niemann, H. and Kues, W.A.
Zuechtungskunde 83
(1): 47-67.
January 2011
Insertional engineering of chromosomes with Sleeping Beauty transposition: an overview.
Grabundzija, I., Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384 and Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658
In:
Mammalian Chromosome Engineering.
Methods in Molecular Biology, 738
.
Springer / Humana Press, 69-85.
2011
2010
The expanding universe of transposon technologies for gene and cell engineering.
Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658 and Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384
Mobile DNA 1
(1): 25.
7 December 2010
Herpes simplex virus/Sleeping Beauty Vector-based embryonic gene transfer using the HSB5 mutant: loss of apparent transposition hyperactivity in vivo.
de Silva, S., Mastrangelo, M.A., Lotta, L.T., Burris, C.A., Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658 and Bowers, W.J.
Human Gene Therapy 21
(11): 1603-1613.
19 November 2010
A DNA-transposon-based approach to functional screening in neural stem cells.
Albieri, I., Onorati, M., Calabrese, G., Moiana, A., Biasci, D., Badaloni, A., Camnasio, S., Spiliotopoulos, D., Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Cattaneo, E. and Consalez, G.G.
Journal of Biotechnology 150
(1): 11-21.
1 October 2010
Novel hyperactive transposons for genetic modification of induced puripotent and adult stem cells: a non-viral paradigm for coaxed differentiation.
Belay, E., Matrai, J., Acosta-Sanchez, A., Ma, L., Quattrocelli, M., Mates, L. ORCID: https://orcid.org/0000-0002-0058-470X, Sancho-Bru, P., Geraerts, M., Yan, B., Vermeesch, J., Rincon, M.Y., Samara-Kuko, E., Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Verfaillie, C.M., Sampaolesi, M., Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Vandendriessche, T. and Chuah, M.K.
Stem Cells 28
(10): 1760-1771.
October 2010
Translating Sleeping Beauty transposition into cellular therapies: Victories and challenges.
Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Hackett, P.B., Cooper, L.J. and Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658
BioEssays 32
(9): 756-767.
September 2010
Novel strong tissue specific promoter for gene expression in human germ cells.
Kuzmin, D., Gogvadze, E., Kholodenko, R., Grzela, D.P. ORCID: https://orcid.org/0000-0002-0667-6488, Mityaev, M., Vinogradova, T., Kopantzev, E., Malakhova, G., Suntsova, M., Sokov, D., Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658 and Buzdin, A.
BMC Biotechnology 10
(1): 58.
17 August 2010
Repetitive elements and genome instability.
Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658 and Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384
Seminars in Cancer Biology 20
(4): 197-199.
August 2010
Comparative analysis of transposable element vector systems in human cells.
Grabundzija, I., Irgang, M., Mates, L. ORCID: https://orcid.org/0000-0002-0058-470X, Belay, E., Matrai, J., Gogol-Doering, A. ORCID: https://orcid.org/0009-0001-7697-0551, Kawakami, K., Chen, W. ORCID: https://orcid.org/0000-0003-3263-1627, Ruiz, P., Chuah, M.K., Vandendriessche, T., Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384 and Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658
Molecular Therapy 18
(6): 1200-1209.
June 2010
Generating knockout rats by transposon mutagenesis in spermatogonial stem cells.
Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Froehlich, J., Grabundzija, I., Shirley, J.R., Powell, H.M., Chapman, K.M., Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658 and Hamra, F.K.
Nature Methods 7
(6): 443-445.
June 2010
Efficient conditional and promoter-specific in vivo expression of cDNAs of choice by taking advantage of recombinase-mediated cassette exchange using FlEx gene traps.
Schebelle, L., Wolf, C., Stribl, C., Javaheri, T., Schnuetgen, F., Ettinger, A., Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Hansen, J., Ruiz, P., von Melchner, H., Wurst, W. and Floss, T.
Nucleic Acids Research 38
(9): e106.
May 2010
A novel active endogenous retrovirus family contributes to genome variability in rat inbred strains.
Wang, Y. ORCID: https://orcid.org/0000-0001-8269-5296, Liska, F., Gosele, C., Sedova, L., Kren, V., Krenova, D., Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Huebner, N. ORCID: https://orcid.org/0000-0002-1218-6223 and Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384
Genome Research 20
(1): 19-27.
January 2010
Unique functions of repetitive transcriptomes.
Schumann, G.G., Gogvadze, E.V., Osanai-Futahashi, M., Kuroki, A., Muenk, C., Fujiwara, H., Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658 and Buzdin, A.A.
International Review of Cell and Molecular Biology 285
: 115-188.
2010
2009
Efficient stable gene transfer into human cells by Sleeping Beauty transposon vectors.
Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Chuah, M.K., VandenDriessche, T. and Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658
Methods 49
(3): 287-297.
November 2009
Emerging potential of transposons for gene therapy and generation of induced pluripotent stem cells.
Vandendriessche, T., Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384 and Chuah, M.K.
Blood 114
(8): 1461-1468.
20 August 2009
Stable gene transfer and expression in cord blood-derived CD34+ hematopoietic stem and progenitor cells by a hyperactive Sleeping Beauty transposon system.
Xue, X., Huang, X., Nodland, S.E., Mates, L. ORCID: https://orcid.org/0000-0002-0058-470X, Ma, L., Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Lebien, T.W., McIvor, R.S., Wagner, J.E. and Zhou, X.
Blood 114
(7): 1319-1330.
13 August 2009
Hybrid lentivirus-transposon vectors with a random integration profile in human cells.
Staunstrup, N.H., Moldt, B., Mates, L. ORCID: https://orcid.org/0000-0002-0058-470X, Villesen, P., Jakobsen, M., Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384 and Mikkelsen, J.G.
Molecular Therapy 17
(7): 1205-1214.
July 2009
Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates.
Mates, L. ORCID: https://orcid.org/0000-0002-0058-470X, Chuah, M.K., Belay, E., Jerchow, B. ORCID: https://orcid.org/0000-0002-7031-8730, Manoj, N., Acosta-Sanchez, A., Grzela, D.P. ORCID: https://orcid.org/0000-0002-0667-6488, Schmitt, A., Becker, K., Matrai, J., Ma, L., Samara-Kuko, E., Gysemans, C., Pryputniewicz, D., Miskey, C. ORCID: https://orcid.org/0000-0002-7566-9556, Fletcher, B., Vandendriessche, T., Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658 and Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384
Nature Genetics 41
(6): 753-761.
June 2009
Transposon-mediated genome manipulation in vertebrates.
Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Li, M.A., Mates, L. ORCID: https://orcid.org/0000-0002-0058-470X, Boeke, J.D., Nagy, A., Bradley, A. and Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384
Nature Methods 6
(6): 415-422.
June 2009
Genomic parasites and genome evolution.
Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658
Genome Biology 10
(4): 306.
15 April 2009
Molecular domestication of transposable elements: From detrimental parasites to useful host genes.
Sinzelle, L., Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384 and Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658
Cellular and Molecular Life Sciences 66
(6): 1073-1093.
March 2009
Applying a "double-feature" promoter to identify cardiomyocytes differentiated from human embryonic stem cells following transposon-based gene delivery.
Orban, T.I., Apati, A., Nemeth, A., Varga, N., Krizsik, V., Schamberger, A., Szebenyi, K., Erdei, Z., Varady, G., Karaszi, E., Homolya, L., Nemet, K., Gocza, E., Miskey, C. ORCID: https://orcid.org/0000-0002-7566-9556, Mates, L. ORCID: https://orcid.org/0000-0002-0058-470X, Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384 and Sarkadi, B.
Stem Cells 27
(5): 1077-1087.
20 February 2009
Interactions of transposons with the cellular DNA repair machinery.
Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Wang, Y. ORCID: https://orcid.org/0000-0001-8269-5296 and Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658
Genome Dynamics and Stability 4
: 133-176.
2009
Transposable elements as plasmid-based vectors for long-term gene transfer into tumors.
Ohlfest, J.R., Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658 and Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384
Methods in Molecular Biology 542
(Part 2): 105-116.
2009
Transposon-host cell interactions in the regulation of Sleeping Beauty transposition.
Walisko, O., Jursch, T., Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384 and Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658
Genome Dynamics and Stability 4
: 109-132.
2009
2008
Targeted gene insertion for molecular medicine.
Voigt, K., Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384 and Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658
Journal of Molecular Medicine 86
(11): 1205-1219.
November 2008
Progress and prospects in rat genetics: a community view.
Aitman, T.J., Critser, J.K., Cuppen, E., Dominiczak, A., Fernandez-Suarez, X.M., Flint, J., Gauguier, D., Geurts, A.M., Gould, M., Harris, P.C., Holmdahl, R., Huebner, N. ORCID: https://orcid.org/0000-0002-1218-6223, Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Jacob, H.J., Kuramoto, T., Kwitek, A.E., Marrone, A., Mashimo, T., Moreno, C., Mullins, J., Mullins, L., Olsson, T., Pravenec, M. ORCID: https://orcid.org/0000-0001-9197-5871, Riley, L., Saar, K. ORCID: https://orcid.org/0000-0002-4483-1557, Serikawa, T., Shull, J.D., Szpirer, C., Twigger, S.N., Voigt, B. and Worley, K.C.
Nature Genetics 40
(5): 516-22.
May 2008
Transposition of a reconstructed Harbinger element in human cells and functional homology with two transposon-derived cellular genes.
Sinzelle, L., Kapitonov, V.V., Grzela, D.P. ORCID: https://orcid.org/0000-0002-0667-6488, Jursch, T., Jurka, J., Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384 and Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658
Proceedings of the National Academy of Sciences of the United States of America 105
(12): 4715-4720.
25 March 2008
Transcriptional activities of the Sleeping Beauty transposon and shielding its genetic cargo with insulators.
Walisko, O., Schorn, A., Rolfs, F., Devaraj, A. ORCID: https://orcid.org/0000-0002-8685-6728, Miskey, C. ORCID: https://orcid.org/0000-0002-7566-9556, Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384 and Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658
Molecular Therapy 16
(2): 359-369.
February 2008
Insertional mutagenesis of the mouse germline with Sleeping Beauty transposition.
Takeda, J., Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384 and Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658
Methods in Molecular Biology 435
: 109-125.
2008
2007
Technology transfer from worms and flies to vertebrates: transposition-based genome manipulations and their future perspectives.
Mates, L. ORCID: https://orcid.org/0000-0002-0058-470X, Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384 and Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658
Genome Biology 8 Suppl 1
: S1.
31 October 2007
The Ancient Mariner Sails Again: Transposition of the Human Hsmar1 Element by a Reconstructed Transposase and Activities of the SETMAR Protein on Transposon Ends.
Miskey, C. ORCID: https://orcid.org/0000-0002-7566-9556, Papp, B., Mates, L. ORCID: https://orcid.org/0000-0002-0058-470X, Sinzelle, L., Keller, H., Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384 and Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658
Molecular and Cellular Biology 27
(12): 4589-4600.
15 June 2007
Targeted Sleeping Beauty transposition in human cells.
Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Katzer, A., Stuewe, E.E., Fiedler, D., Knespel, S. and Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384
Molecular Therapy 15
(6): 1137-1144.
June 2007
2006
Transposons for gene therapy!
Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658 and Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384
Current Gene Therapy 6
(5): 593-607.
October 2006
Hungary's 'reforms' are threatening basic science.
Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658 and Mates, L. ORCID: https://orcid.org/0000-0002-0058-470X
Nature 443
(7110): 394.
28 September 2006
Sleeping Beauty transposase modulates cell-cycle progression through interaction with Miz-1.
Walisko, O., Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Szabo, K., Kaufman, C.D. ORCID: https://orcid.org/0009-0001-9888-7740, Herold, S. and Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658
Proceedings of the National Academy of Sciences of the United States of America 103
(11): 4062-4067.
14 March 2006
Transposons.
Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Walisko, O. and Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384
In:
Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine ; Vol. 2.
Springer, Berlin [u.a.], 1915-1919.
ISBN 3-540-44244-8
2006
2005
Transposon-based targeting system [Transposon-System zur gezielten Integration].
Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658 and Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384
EP1594971 ; EP1594972 ; EP1594973 ; WO0469994 ; WO0469995 ; WO0470042.
16 November 2005
Frog Prince transposon-based RNAi vectors mediate efficient gene knockdown in human cells.
Kaufman, C.D. ORCID: https://orcid.org/0009-0001-9888-7740, Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Katzer, A. and Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658
Journal of RNAi and Gene Silencing 1
(2): 97-104.
October 2005
Sleeping Beauty hits them all: transposon-mediated saturation mutagenesis in the mouse germline.
Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384 and Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658
Nature Methods 2
(10): 735-736.
October 2005
DNA transposons in vertebrate functional genomics.
Miskey, C. ORCID: https://orcid.org/0000-0002-7566-9556, Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Kawakami, K. and Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658
Cellular and Molecular Life Sciences 62
(6): 629-641.
March 2005
A whole lotta jumpin' goin' on: new transposon tools for vertebrate functional genomics.
Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658 and Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384
Trends in Genetics 21
(1): 8-11.
1 January 2005
2004
Development of hyperactive Sleeping Beauty transposon vectors by mutational analysis.
Zayed, H. ORCID: https://orcid.org/0000-0001-8838-6638, Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Walisko, O. and Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658
Molecular Therapy 9
(2): 292-304.
1 February 2004
Sleeping Beauty transposition: biology and applications for molecular therapy.
Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384 and Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658
Molecular Therapy 9
(2): 147-156.
1 February 2004
Healing the wounds inflicted by Sleeping Beauty transposition by double-strand break repair in mammalian somatic cells.
Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Stuewe, E.E., Fiedler, D., Katzer, A., Jeggo, P.A. and Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658
Molecular Cell 13
(2): 279-290.
1 January 2004
The Sleeping Beauty transposable element: evolution, regulation and genetic applications.
Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Kaufman, C.D. ORCID: https://orcid.org/0009-0001-9888-7740, Zayed, H. ORCID: https://orcid.org/0000-0001-8838-6638, Miskey, C. ORCID: https://orcid.org/0000-0002-7566-9556, Walisko, O. and Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384
Current Issues in Molecular Biology 6
(1): 43-55.
1 January 2004
Transposable elements for transgenesis and insertional mutagenesis in vertebrates: a contemporary review of experimental strategies.
Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658 and Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384
In:
Mobile Genetic Elements: Protocols and Genomic Applications.
Methods in Molecular Biology ; 260, 260
.
Humana Press, Totowa, NJ, 255-276.
ISBN 1-58829-007-7
1 January 2004
2003
Frog Prince, ein Transposonvektor fuer den Gentransfer bei Wirbeltieren [The Frog Prince, a transposon vector for gene transfer in vertebrates].
Miskey, C. ORCID: https://orcid.org/0000-0002-7566-9556, Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384 and Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658
DE10224242A1 ; EP1507865 ; WO03100070.
11 December 2003
The Frog Prince: a reconstructed transposon from Rana pipiens with high transpositional activity in vertebrate cells.
Miskey, C. ORCID: https://orcid.org/0000-0002-7566-9556, Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Plasterk, R.H. and Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658
Nucleic Acids Research 31
(23): 6873-6881.
1 December 2003
The DNA-bending protein HMGB1 is a cellular cofactor of Sleeping Beauty transposition.
Zayed, H. ORCID: https://orcid.org/0000-0001-8838-6638, Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Khare, D., Heinemann, U. ORCID: https://orcid.org/0000-0002-8191-3850 and Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658
Nucleic Acids Research 31
(9): 2313-2322.
1 May 2003
2002
Common physical properties of DNA affecting target site selection of Sleeping Beauty and other Tc1/mariner transposable elements.
Vigdal, T.J., Kaufman, C.D. ORCID: https://orcid.org/0009-0001-9888-7740, Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Voytas, D.F. and Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658
Journal of Molecular Biology 323
(3): 441-452.
25 October 2002
Involvement of a bifunctional, paired-like DNA-binding domain and a transpositional enhancer in Sleeping Beauty transposition.
Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Khare, D., Behlke, J., Heinemann, U. ORCID: https://orcid.org/0000-0002-8191-3850, Plasterk, R.H. and Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658
Journal of Biological Chemistry 277
(37): 34581-34588.
13 September 2002
2000
Sleeping Beauty, a wide host-range transposon vector for genetic transformation in vertebrates.
Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658 and Plasterk, R.H.
Journal of Molecular Biology 302
: 93-102.
8 September 2000
Somatic integration and long-term transgene expression in normal and haemophilic mice using a DNA transposon system.
Yant, S.R., Meuse, L., Chiu, W., Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384 and Kay, M.A.
Nature Genetics 25
(1): 35-41.
1 May 2000
1999
Resident aliens: the Tc1/mariner superfamily of transposable elements.
Plasterk, R.H., Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384 and Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658
Trends in Genetics 15
: 326-332.
1 August 1999
Nucleic acid transfer vector for the introduction of nucleic acid into the DNA of a cell.
Hackett, B.P., Clark, J.K., Dupuy, J.A., Ekker, C.S., Largaespada, A.D., Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658 and Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384
EP1034258 ; WO9925817.
27 May 1999
Development of genetic tools for transgenic animals.
Hackett, P.B., Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658 and Caldovic, L.
In:
Transgenic Animals in Agriculture.
CAB International, Wallingford, UK, 19-35.
ISBN 9780851992938
1 January 1999
Short inverted-repeat transposable elements in teleost fish and implications for a mechanism of their amplification.
Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Shimoda, N., Mohn, D., Okamoto, H. and Hackett, P.B.
Journal of Molecular Evolution 48
: 13-21.
1 January 1999
1998
Elements transposables: des outils permettant la mutagenese et le transgenese chez les vertebres [Transposable elements as tools from mutagenesis and transgenesis of vertebrates].
Plasterk, R.H., Van Luenen, H., Vos, C., Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384 and Fischer, S.
Pathologie Biologie 46
: 674-675.
1 November 1998
Chromosomal transposition of a Tc1/mariner-like element in mouse embryonic stem cells.
Luo, G., Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384 and Bradley, A.
Proceedings of the National Academy of Sciences of the United States of America 95
(18): 10769-10773.
1 September 1998
1997
Molecular reconstruction of Sleeping Beauty, a Tc1-like transposon from fish, and its transposition in human cells.
Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Hackett, P.B., Plasterk, R.H. and Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384
Cell 91
(4): 501-510.
14 November 1997
Repetitive elements and their genetic applications in zebrafish.
Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658 and Hackett, P.B.
Biochemistry and Cell Biology 75
(5): 507-523.
1 October 1997
Cloning and characterization of the genes of the CeqI restriction-modification system.
Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Jobbagy, Z., Takacs, I. and Duda, E.
International Journal of Biochemistry and Cell Biology 29
: 895-900.
1 June 1997
Family of plasmid vectors for the expression of beta-galactosidase fusion proteins in eukaryotic cells.
Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658 and Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384
Biotechniques 22
: 254-258.
1 February 1997
1996
Identification of functional domains and evolution of Tc1-like transposable elements.
Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Minter, A. and Hackett, P.B.
Proceedings of the National Academy of Sciences of the United States of America 93
(10): 5008-5013.
14 May 1996
DANA elements: a family of composite, tRNA-derived short interspersed DNA elements associated with mutational activities in zebrafish (Danio rerio).
Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Garcia-Estefania, D., Fahrenkrug, S.C. and Hackett, P.B.
Proceedings of the National Academy of Sciences of the United States of America 93
(3): 1077-1081.
6 February 1996
1995
Characterization of a Tc1-like transposable element in zebrafish (Danio rerio).
Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658 and Hackett, P.B.
Molecular and General Genetics 247
(3): 312-322.
10 May 1995
1993
Two-stage ligation-mediated PCR enhances the detection of integrated transgenic DNA.
Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384 and Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658
Biotechniques 15, 5
: 814-818.
1 November 1993
Enhanced incorporation of transgenic DNA into zebrafish chromosomes by a retroviral integration protein.
Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384 and Hackett, P.B.
Molecular Marine Biology and Biotechnology 2
(3): 162-173.
June 1993
1992
Purification and characterization of CeqI restriction endonuclease.
Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Jobbagy, Z. and Duda, E.
Zeitschrift fuer Naturforschung C, A Journal of Biosciences 47
: 830-834.
1 November 1992
Positive co-operative interaction between the subunits of CeqI restriction endonuclease.
Jobbagy, Z., Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384 and Duda, E.
Biochemical Journal 286
: 85-88.
15 August 1992
1989
‘Star’ activity and complete loss of specificity of CeqI endonuclease.
Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384 and Duda, E.
Biochemical Journal 258
(1): 301-303.
February 1989
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