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Research Teams (19837)
- Henssen, Anton (MDC/ECRC) (79)

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BIOspektrum

Karzinogenese: Big Bang oder kontinuierliche Evolution?
Haase, K. and Schwarz, R.F.
BIOspektrum 26 (7): 718-720. November 2020

BMC Cancer

CD171- and GD2-specific CAR-T cells potently target retinoblastoma cells in preclinical in vitro testing.
Andersch, L. and Radke, J. and Klaus, A. and Schwiebert, S. and Winkler, A. and Schumann, E. and Grunewald, L. and Zirngibl, F. and Flemmig, C. and Jensen, M.C. and Rossig, C. and Joussen, A. and Henssen, A. and Eggert, A. and Schulte, J.H. and Künkele, A.
BMC Cancer 19 (1): 895. 9 September 2019

BMC Genomics

Forward genetic screen of human transposase genomic rearrangements.
Henssen, A.G. and Jiang, E. and Zhuang, J. and Pinello, L. and Socci, N.D. and Koche, R. and Gonen, M. and Villasante, C.M. and Armstrong, S.A. and Bauer, D.E. and Weng, Z. and Kentsis, A.
BMC Genomics 17 : 548. 4 August 2016

Biochemical Society Transactions

Extrachromosomal DNA (ecDNA): an origin of tumor heterogeneity, genomic remodeling, and drug resistance.
Pecorino, L.T. and Verhaak, R.G.W. and Henssen, A. and Mischel, P.S.
Biochemical Society Transactions 50 (6): 1911-1920. December 2022

Brain

Parallel in-depth analysis of repeat expansions in ataxia patients by long-read sequencing.
Erdmann, H. and Schöberl, F. and Giurgiu, M. and Leal Silva, R.M. and Scholz, V. and Scharf, F. and Wendlandt, M. and Kleinle, S. and Deschauer, M. and Nübling, G. and Heide, W. and Babacan, S.S. and Schneider, C. and Neuhann, T. and Hahn, K. and Schoser, B. and Holinski-Feder, E. and Wolf, D.A. and Abicht, A.
Brain 146 (5): 1831-1843. May 2023

Cancer Discovery

Passenger gene coamplifications create collateral therapeutic vulnerabilities in cancer.
Bei, Y. and Brame, Luca and Kirchner, M. and Fritsche-Guenther, R. and Kunz, S. and Bhattacharya, A. and Rusu, M.C. and Gürgen, D. and Dubois, F.P.B. and Köppke, J.K.C. and Proba, J. and Wittstruck, N. and Sidorova, O.A. and Chamorro González, R. and Dorado Garcia, H. and Brückner, L. and Xu, R. and Giurgiu, M. and Rodriguez-Fos, E. and Yu, Q. and Spanjaard, B. and Koche, R.P, and Schmitt, C.A. and Schulte, J.H. and Eggert, A. and Haase, K. and Kirwan, J. and Hagemann, A.I. and Mertins, P. and Dörr, J.R. and Henssen, A.G.
Cancer Discovery 14 (3): 492-507. 1 March 2024

Shedding light on ecDNA behavior using CRISPR-based live-cell imaging.
Henssen, A.G.
Cancer Discovery 12 (2): 293-295. 9 February 2022

Cancer Letters

Synergistic activity of BET inhibitor MK-8628 and PLK inhibitor Volasertib in preclinical models of medulloblastoma.
Han, Y. and Lindner, S. and Bei, Y. and Garcia, H.D. and Timme, N. and Althoff, K. and Odersky, A. and Schramm, A. and Lissat, A. and Künkele, A. and Deubzer, H.E. and Eggert, A. and Schulte, J.H. and Henssen, A.G.
Cancer Letters 445 : 24-33. 31 March 2019

Cancer Research

Subclone eradication analysis identifies targets for enhanced cancer therapy and reveals L1 retrotransposition as a dynamic source of cancer heterogeneity.
Ketola, K. and Kaljunen, H. and Taavitsainen, S. and Kaarijärvi, R. and Järvelä, E. and Rodriguez Martin, B. and Haase, K. and Woodcock, D.J. and Tubio, J. and Wedge, D.C. and Nykter, M. and Bova, G.S.
Cancer Research 81 (19): 4901-4909. October 2021

Cancers

Inhibiting lysine demethylase 1A improves L1CAM-specific CAR T cell therapy by unleashing antigen-independent killing via the FAS-FASL axis.
Sulejmani, O. and Grunewald, L. and Andersch, L. and Schwiebert, S. and Klaus, A. and Winkler, A. and Astrahantseff, K. and Eggert, A. and Henssen, A.G. and Schulte, J.H. and Anders, K. and Künkele, A.
Cancers 13 (21): 5489. 31 October 2021

CD28 co-stimulus achieves superior CAR T cell effector function against solid tumors than 4-1BB co-stimulus.
Textor, A. and Grunewald, L. and Anders, K. and Klaus, A. and Schwiebert, S. and Winkler, A. and Stecklum, M. and Rolff, J. and Henssen, A.G. and Höpken, U.E. and Eggert, A. and Schulte, J.H. and Jensen, M.C. and Blankenstein, T. and Künkele, A.
Cancers 13 (5): 1050. 2 March 2021

High specificity of BCL11B and GLG1 for EWSR1-FLI1 and EWSR1-ERG positive Ewing sarcoma.
Orth, M.F. and Hölting, T.L.B. and Dallmayer, M. and Wehweck, F.S. and Paul, T. and Musa, J. and Baldauf, M.C. and Surdez, D. and Delattre, O. and Knott, M.M.L. and Romero-Pérez, L. and Kasan, M. and Cidre-Aranaz, F. and Gerke, J.S. and Ohmura, S. and Li, J. and Marchetto, A. and Henssen, A.G. and Özen, Ö. and Sugita, S. and Hasegawa, T. and Kanaseki, T. and Bertram, S. and Dirksen, U. and Hartmann, W. and Kirchner, T. and Grünewald, T.G.P.
Cancers 12 (3): 644. 10 March 2020

Cell Genomics

Mutational topography reflects clinical neuroblastoma heterogeneity.
Rodriguez-Fos, E. and Planas-Fèlix, M. and Burkert, M. and Puiggròs, M. and Toedling, J. and Thiessen, N. and Blanc, E. and Szymansky, A. and Hertwig, F. and Ishaque, N. and Beule, D. and Torrents, D. and Eggert, A. and Koche, R.P. and Schwarz, R.F. and Haase, K. and Schulte, J.H. and Henssen, A.G.
Cell Genomics 3 (10): 100402. 11 October 2023

Long-read sequencing of diagnosis and post-therapy medulloblastoma reveals complex rearrangement patterns and epigenetic signatures.
Rausch, T. and Snajder, R. and Leger, A. and Simovic, M. and Giurgiu, M. and Villacorta, L. and Henssen, A.G. and Fröhling, S. and Stegle, O. and Birney, E. and Bonder, M.J. and Ernst, A. and Korbel, J.O.
Cell Genomics 3 (4): 100281. 12 April 2023

Cells

Doxorubicin changes the spatial organization of the genome around active promoters.
Stefanova, M.E. and Ing-Simmons, E. and Stefanov, S. and Flyamer, I. and Dorado Garcia, H. and Schöpflin, R. and Henssen, A.G. and Vaquerizas, J.M. and Mundlos, S.
Cells 12 (15): 2001. 4 August 2023

Clinical Cancer Research

Targeting MYCN-driven transcription by BET-bromodomain inhibition.
Henssen, A. and Althoff, K. and Odersky, A. and Beckers, A. and Koche, R. and Speleman, F. and Schäfers, S. and Bell, E. and Nortmeyer, M. and Westermann, F. and De Preter, K. and Florin, A. and Heukamp, L. and Spruessel, A. and Astrahanseff, K. and Lindner, S. and Sadowski, N. and Schramm, A. and Astorgues-Xerri, L. and Riveiro, M.E. and Eggert, A. and Cvitkovic, E. and Schulte, J.H.
Clinical Cancer Research 22 (10): 2470-2481. May 2016

Clinical Chemistry

What is extrachromosomal circular DNA and what does it do?
Chiu, R.W.K. and Dutta, A. and Henssen, A.G. and Lo, Y.M.D. and Mischel, P. and Regenberg, B.
Clinical Chemistry 66 (6): 754-759. June 2020

Cortex

Cytoarchitecture and probability maps of the human medial orbitofrontal cortex.
Henssen, A. and Zilles, K. and Palomero-Gallagher, N. and Schleicher, A. and Mohlberg, H. and Gerboga, F. and Eickhoff, S.B. and Bludau, S. and Amunts, K.
Cortex 75 : 87-112. February 2016

European Journal of Cancer

Paediatric Strategy Forum for medicinal product development of DNA damage response pathway inhibitors in children and adolescents with cancer: ACCELERATE in collaboration with the European Medicines Agency with participation of the Food and Drug Administration.
Pearson, A.D.J. and Federico, S. and Gatz, S.A. and Ortiz, M. and Lesa, G. and Scobie, N. and Gounaris, I. and Weiner, S.L. and Weigel, B. and Unger, T.J. and Stewart, E. and Smith, M. and Slotkin, E.K. and Reaman, G. and Pappo, A. and Nysom, K. and Norga, K. and McDonough, J. and Marshall, L.V. and Ludwinski, D. and Ligas, F. and Karres, D. and Kool, M. and Horner, T.J. and Henssen, A. and Heenen, D. and Hawkins, D.S. and Gore, L. and Bender, J.G. and Galluzzo, S. and Fox, E. and de Rojas, T. and Davies, B.R. and Chakrabarti, J. and Carmichael, J. and Bradford, D. and Blanc, P. and Bernardi, R. and Benchetrit, S. and Akindele, K. and Vassal, G.
European Journal of Cancer 190 : 112950. September 2023

Target actionability review to evaluate CDK4/6 as a therapeutic target in paediatric solid and brain tumours.
Schubert, N.A. and Chen, C.Y. and Rodríguez, A. and Koster, J. and Dowless, M. and Pfister, S.M. and Shields, D.J. and Stancato, L.F. and Vassal, G. and Caron, H.N. and van den Boogaard, M.L. and Henssen, A.G. and Molenaar, J.J.
European Journal of Cancer 170 : 196-208. July 2022

Frontiers in Genetics

Detection and validation of circular DNA fragments using nanopore sequencing.
Tüns, A.I. and Hartmann, T. and Magin, S. and Chamorro González, R. and Henssen, A.G. and Rahmann, S. and Schramm, A. and Köster, J.
Frontiers in Genetics 13 : 867018. 30 May 2022

Frontiers in Immunology

A reproducible bioprinted 3D tumor model serves as a preselection tool for CAR T cell therapy optimization.
Grunewald, L. and Lam, T. and Andersch, L. and Klaus, A. and Schwiebert, S. and Winkler, A. and Gauert, A. and Heeren-Hagemann, A.I. and Astrahantseff, K. and Klironomos, F. and Thomas, A. and Deubzer, H.E. and Henssen, A.G. and Eggert, A. and Schulte, J.H. and Anders, K. and Kloke, L. and Künkele, A.
Frontiers in Immunology 12 : 689697. 29 June 2021

Tumor-derived extracellular vesicles impair CD171-specific CD4(+) CAR T cell efficacy.
Ali, S. and Toews, K. and Schwiebert, S. and Klaus, A. and Winkler, A. and Grunewald, L. and Oevermann, L. and Deubzer, H.E. and Tüns, A. and Jensen, M.C. and Henssen, A.G. and Eggert, A. and Schulte, J.H. and Schwich, E. and Rebmann, V. and Schramm, A. and Künkele, A.
Frontiers in Immunology 11 : 531. 31 March 2020

Frontiers in Oncology

Current and future treatment strategies for rhabdomyosarcoma.
Chen, C. and Dorado-Garcia, H. and Scheer, M. and Henssen, A.G.
Frontiers in Oncology 9 : 1458. 20 December 2019

Genome Biology

MEDICC2: whole-genome doubling aware copy-number phylogenies for cancer evolution.
Kaufmann, T.L. and Petkovic, M. and Watkins, T.B.K. and Colliver, E.C. and Laskina, S. and Thapa, N. and Minussi, D.C. and Navin, N. and Swanton, C. and Van Loo, P. and Haase, K. and Tarabichi, M. and Schwarz, R.F.
Genome Biology 23 (1): 241. 14 November 2022

Haematologica

Rituximab therapy after pediatric hematopoietic stem cell transplantation can cause prolonged B cell impairment and increases the risk for infections - a retrospective matched cohort study.
Launspach, M. and Temel, D. and Ohlendorf, E. and Zirngibl, F. and Materne, B. and Oevermann, L. and Deubzer, H.E. and Henssen, A.G. and Künkele, A. and Hundsdörfer, P. and von Bernuth, H. and Pruß, A. and Eggert, A. and von Stackelberg, A. and Lang, P. and Schulte, J.H.
Haematologica 108 (1): 267-272. January 2023

International Journal of Cancer

Reflection of neuroblastoma intratumor heterogeneity in the new OHC-NB1 disease model.
Thole, T.M. and Toedling, J. and Sprüssel, A. and Pfeil, S. and Savelyeva, L. and Capper, D. and Messerschmidt, C. and Beule, D. and Groeneveld-Krentz, S. and Eckert, C. and Gambara, G. and Henssen, A.G. and Finkler, S. and Schulte, J.H. and Sieber, A. and Bluethgen, N. and Regenbrecht, C.R.A. and Künkele, A. and Lodrini, M. and Eggert, A. and Deubzer, H.E.
International Journal of Cancer 146 (4): 1031-1041. 15 February 2020

JCI Insight

Prohibitin is a prognostic marker and therapeutic target to block chemotherapy resistance in Wilms' tumor.
Ortiz, M.V. and Ahmed, S. and Burns, M. and Henssen, A.G. and Hollmann, T.J. and MacArthur, I. and Gunasekera, S. and Gaewsky, L. and Bradwin, G. and Ryan, J. and Letai, A. and He, Y. and Naranjo, A. and Chi, Y.Y. and LaQuaglia, M. and Heaton, T. and Cifani, P. and Dome, J.S. and Gadd, S. and Perlman, E. and Mullen, E. and Steen, H. and Kentsis, A.
JCI Insight 4 (15): e127098. 8 August 2019

Prohibitin promotes dedifferentiation and is a potential therapeutic target in neuroblastoma.
MacArthur, I.C. and Bei, Y. and Garcia, H.D. and Ortiz, M.V. and Toedling, J. and Klironomos, F. and Rolff, J. and Eggert, A. and Schulte, J.H. and Kentsis, A. and Henssen, A.G.
JCI Insight 4 (10): e127130. 16 May 2019

Emerging functions of DNA transposases and oncogenic mutators in childhood cancer development.
Henssen, A.G. and Kentsis, A.
JCI Insight 3 (20): 123172. 18 October 2018

JCO Precision Oncology

Genomic evolution and personalized therapy of an infantile fibrosarcoma harboring an NTRK oncogenic fusion.
Thorwarth, A. and Haase, K. and Röefzaad, C. and Pajtler, K.W. and Schramm, K. and Hauptmann, K. and Behnke, A. and Vokuhl, C. and Elgeti, T. and Gratopp, A. and Schulte, J.H. and Scheer, M. and Hernáiz Driever, P. and Nysom, K. and Eggert, A. and Henssen, A.G. and Deubzer, H.E.
JCO Precision Oncology 6 : e2100283. 25 May 2022

Journal of Cancer Research and Clinical Oncology

Pre-operative radiotherapy is associated with superior local relapse-free survival in advanced synovial sarcoma.
Scheer, M. and Hallmen, E. and Vokuhl, C. and Fuchs, J. and Tunn, P.U. and Münter, M. and Timmermann, B. and Bauer, S. and Henssen, A.G. and Kazanowska, B. and Niggli, F. and Ladenstein, R. and Ljungman, G. and Eggert, A. and Klingebiel, T. and Koscielniak, E.
Journal of Cancer Research and Clinical Oncology 149 (5): 1717-1731. May 2023

The effect of adjuvant therapies on long-term outcome for primary resected synovial sarcoma in a series of mainly children and adolescents.
Scheer, M. and Vokuhl, C. and Bauer, S. and Fuchs, J. and Loff, S. and Timmermann, B. and Münter, M. and Henssen, A.G. and Kazanowska, B. and Niggli, F. and Ladenstein, R. and Ljungman, G. and Koscielniak, E. and Klingebiel, T.
Journal of Cancer Research and Clinical Oncology 147 (12): 3735-3747. December 2021

Synovial sarcoma disease characteristics and primary tumor sites differ between patient age groups: a report of the Cooperative Weichteilsarkom Studiengruppe (CWS).
Scheer, M. and Blank, B. and Bauer, S. and Vokuhl, C. and Stegmaier, S. and Feuchtgruber, S. and Henssen, A. and Sparber-Sauer, M. and Eggert, A. and Handgretinger, R. and Pekrun, A. and Rossig, C. and Rutkowski, S. and Schlegel, P.G. and Schrappe, M. and Simon, T. and Kazanowska, B. and Niggli, F. and Ladenstein, R. and Ljungman, G. and Jahnukainen, K. and Fuchs, J. and Bielack, S.S. and Koscielniak, E. and Klingebiel, T.
Journal of Cancer Research and Clinical Oncology 146 (4): 953-960. April 2020

Journal of Experimental & Clinical Cancer Research

Class I histone deacetylases (HDAC) critically contribute to Ewing sarcoma pathogenesis.
Schmidt, O. and Nehls, N. and Prexler, C. and von Heyking, K. and Groll, T. and Pardon, K. and Garcia, H.D. and Hensel, T. and Gürgen, D. and Henssen, A.G. and Eggert, A. and Steiger, K. and Burdach, S. and Richter, G.H.S.
Journal of Experimental & Clinical Cancer Research 40 (1): 322. 15 October 2021

Journal of Personalized Medicine

Neuroblastoma risk assessment and treatment stratification with hybrid capture-based panel sequencing.
Szymansky, A. and Kruetzfeldt, L.M. and Heukamp, L.C. and Hertwig, F. and Theissen, J. and Deubzer, H.E. and Willing, E.M. and Menon, R. and Fuchs, S. and Thole, T. and Schulte, S. and Schmelz, K. and Künkele, A. and Lang, P. and Fuchs, J. and Eggert, A. and Eckert, C. and Fischer, M. and Henssen, A.G. and Rodriguez-Fos, E. and Schulte, J.H.
Journal of Personalized Medicine 11 (8): 691. August 2021

Life Science Alliance

Negative correlation of single-cell PAX3:FOXO1 expression with tumorigenicity in rhabdomyosarcoma.
Regina, C. and Hamed, E. and Andrieux, G. and Angenendt, S. and Schneider, M. and Ku, M. and Follo, M. and Wachtel, M. and Ke, E. and Kikuchi, K. and Henssen, A.G. and Schäfer, B.W. and Boerries, M. and Wagers, A.J. and Keller, C. and Hettmer, S.
Life Science Alliance 4 (9): e202001002. September 2021

Molecular Cancer

Mutations in ALK signaling pathways conferring resistance to ALK inhibitor treatment lead to collateral vulnerabilities in neuroblastoma cells.
Berlak, M. and Tucker, E. and Dorel, M. and Winkler, A. and McGearey, A. and Rodriguez-Fos, E. and da Costa, B.M. and Barker, K. and Fyle, E. and Calton, E. and Eising, S. and Ober, K. and Hughes, D. and Koutroumanidou, E. and Carter, P. and Stankunaite, R. and Proszek, P. and Jain, N. and Rosswog, C. and Dorado-Garcia, H. and Molenaar, J.J. and Hubank, M. and Barone, G. and Anderson, J. and Lang, P. and Deubzer, H.E. and Künkele, A. and Fischer, M. and Eggert, A. and Kloft, C. and Henssen, A.G. and Boettcher, M. and Hertwig, F. and Blüthgen, N. and Chesler, L. and Schulte, J.H.
Molecular Cancer 21 (1): 126. 10 June 2022

Molecular Cancer Therapeutics

Elimusertib has antitumor activity in preclinical patient-derived pediatric solid tumor models.
Pusch, F.F. and Dorado Garcia, H. and Xu, R. and Gürgen, D. and Bei, Y. and Brückner, L. and Röefzaad, C. and von Stebut, J. and Bardinet, V. and Chamorro Gonzalez, R. and Eggert, A. and Schulte, J.H. and Hundsdörfer, P. and Seifert, G. and Haase, K. and Schäfer, B.W. and Wachtel, M. and Kühl, A.A. and Ortiz, M.V. and Wengner, A.M. and Scheer, M. and Henssen, A.G.
Molecular Cancer Therapeutics 23 (4): 507-519. 2 April 2024

Molecular Carcinogenesis

Central memory phenotype drives success of checkpoint inhibition in combination with CAR T cells.
Toews, K. and Grunewald, L. and Schwiebert, S. and Klaus, A. and Winkler, A. and Ali, S. and Zirngibl, F. and Astrahantseff, K. and Wagner, D.L. and Henssen, A.G. and Deubzer, H.E. and Schulte, J.H. and Ochsenreither, S. and Eggert, A. and Künkele, A.
Molecular Carcinogenesis 59 (7): 724-273. July 2020

Nature

Genetic determinants of micronucleus formation in vivo.
Adams, D.J. and Barlas, B. and McIntyre, R.E. and Salguero, I. and van der Weyden, L. and Barros, A. and Vicente, J.R. and Karimpour, N. and Haider, A. and Ranzani, M. and Turner, G. and Thompson, N.A. and Harle, V. and Olvera-León, R. and Robles-Espinoza, C.D. and Speak, A.O. and Geisler, N. and Weninger, W.J. and Geyer, S.H. and Hewinson, J. and Karp, N.A. and Fu, B. and Yang, F. and Kozik, Z. and Choudhary, J. and Yu, L. and van Ruiten, M.S. and Rowland, B.D. and Lelliott, C.J. and Del Castillo Velasco-Herrera, M. and Verstraten, R. and Bruckner, L. and Henssen, A.G. and Rooimans, M.A. and de Lange, J. and Mohun, T.J. and Arends, M.J. and Kentistou, K.A. and Coelho, P.A. and Zhao, Y. and Zecchini, H. and Perry, J.R.B. and Jackson, S.P. and Balmus, G.
Nature 627 (8002): 130–136. 7 March 2024

ecDNA hubs drive cooperative intermolecular oncogene expression.
Hung, K.L. and Yost, K.E. and Xie, L. and Shi, Q. and Helmsauer, K. and Luebeck, J. and Schöpflin, R. and Lange, J.T. and Chamorro González, R. and Weiser, N.E. and Chen, C. and Valieva, M.E. and Wong, I.T.L. and Wu, S. and Dehkordi, S.R. and Duffy, C.V. and Kraft, K. and Tang, J. and Belk, J.A. and Rose, J.C. and Corces, M.R. and Granja, J.M. and Li, R. and Rajkumar, U. and Friedlein, J. and Bagchi, A. and Satpathy, A.T. and Tjian, R. and Mundlos, S. and Bafna, V. and Henssen, A.G. and Mischel, P.S. and Liu, Z. and Chang, H.Y.
Nature 600 (7890): 731-736. 23 December 2021

Nature Cancer

Combined inhibition of Aurora-A and ATR kinases results in regression of MYCN-amplified neuroblastoma.
Roeschert, I. and Poon, E. and Henssen, A.G. and Dorado Garcia, H. and Gatti, M. and Giansanti, C. and Jamin, Y. and Ade, C.P. and Gallant, P. and Schülein-Völk, C. and Beli, P. and Richards, M. and Rosenfeldt, M. and Altmeyer, M. and Anderson, J. and Eggert, A. and Dobbelstein, M. and Bayliss, R. and Chesler, L. and Büchel, G. and Eilers, M.
Nature Cancer 2 (3): 312-326. March 2021

Nature Communications

Defining the landscape of circular RNAs in neuroblastoma unveils a global suppressive function of MYCN.
Fuchs, S. and Danßmann, C. and Klironomos, F. and Winkler, A. and Fallmann, J. and Kruetzfeldt, L.M. and Szymansky, A. and Naderi, J. and Bernhart, S.H. and Grunewald, L. and Helmsauer, K. and Rodriguez-Fos, E. and Kirchner, M. and Mertins, P. and Astrahantseff, K. and Suenkel, C. and Toedling, J. and Meggetto, F. and Remke, M. and Stadler, P.F. and Hundsdoerfer, P. and Deubzer, H.E. and Künkele, A. and Lang, P. and Fuchs, J. and Henssen, A.G. and Eggert, A. and Rajewsky, N. and Hertwig, F. and Schulte, J.H.
Nature Communications 14 (1): 3936. 4 July 2023

Therapeutic targeting of ATR in alveolar rhabdomyosarcoma.
Dorado Garcia, H. and Pusch, F. and Bei, Y. and von Stebut, J. and Ibáñez, G. and Guillan, K. and Imami, K. and Gürgen, D. and Rolff, J. and Helmsauer, K. and Meyer-Liesener, S. and Timme, N. and Bardinet, V. and Chamorro González, R. and MacArthur, I.C. and Chen, C.Y. and Schulz, J. and Wengner, A.M. and Furth, C. and Lala, B. and Eggert, A. and Seifert, G. and Hundsoerfer, P. and Kirchner, M. and Mertins, P. and Selbach, M. and Lissat, A. and Dubois, F. and Horst, D. and Schulte, J.H. and Spuler, S. and You, D. and Dela Cruz, F. and Kung, A.L. and Haase, K. and Di Virgilio, M. and Scheer, M. and Ortiz, M.V. and Henssen, A.G.
Nature Communications 13 (1): 4297. 25 July 2022

Spatial and temporal intratumour heterogeneity has potential consequences for single biopsy-based neuroblastoma treatment decisions.
Schmelz, K. and Toedling, J. and Huska, M. and Cwikla, M.C. and Kruetzfeldt, L.M. and Proba, J. and Ambros, P.F. and Ambros, I.M. and Boral, S. and Lodrini, M. and Chen, C.Y. and Burkert, M. and Guergen, D. and Szymansky, A. and Astrahantseff, K. and Kuenkele, A. and Haase, K. and Fischer, M. and Deubzer, H.E. and Hertwig, F. and Hundsdoerfer, P. and Henssen, A.G. and Schwarz, R.F. and Schulte, J.H. and Eggert, A.
Nature Communications 12 (1): 6804. 23 November 2021

Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma.
Helmsauer, K. and Valieva, M.E. and Ali, S. and Chamorro Gonzalez, R. and Schöpflin, R. and Röefzaad, C. and Bei, Y. and Dorado Garcia, H. and Rodriguez-Fos, E. and Puiggròs, M. and Kasack, K. and Haase, K. and Keskeny, C. and Chen, C.Y. and Kuschel, L.P. and Euskirchen, P. and Heinrich, V. and Robson, M.I. and Rosswog, C. and Toedling, J. and Szymansky, A. and Hertwig, F. and Fischer, M. and Torrents, D. and Eggert, A. and Schulte, J.H. and Mundlos, S. and Henssen, A.G. and Koche, R.P.
Nature Communications 11 (1): 5823. 16 November 2020

Partner independent fusion gene detection by multiplexed CRISPR-Cas9 enrichment and long read nanopore sequencing.
Stangl, C. and de Blank, S. and Renkens, I. and Westera, L. and Verbeek, T. and Valle-Inclan, J.E. and Chamorro González, R. and Henssen, A.G. and van Roosmalen, M.J. and Stam, R.W. and Voest, E.E. and Kloosterman, W.P. and van Haaften, G. and Monroe, G.R.
Nature Communications 11 (1): 2861. 5 June 2020

Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma.
Marchetto, A. and Ohmura, S. and Orth, M.F. and Knott, M.M.L. and Colombo, M.V. and Arrigoni, C. and Bardinet, V. and Saucier, D. and Wehweck, F.S. and Li, J. and Stein, S. and Gerke, J.S. and Baldauf, M.C. and Musa, J. and Dallmayer, M. and Romero-Pérez, L. and Hölting, T.L.B. and Amatruda, J.F. and Cossarizza, A. and Henssen, A.G. and Kirchner, T. and Moretti, M. and Cidre-Aranaz, F. and Sannino, G. and Grünewald, T.G.P.
Nature Communications 11 (1): 2423. 15 May 2020

TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets.
Decaesteker, B. and Denecker, G. and Van Neste, C. and Dolman, E.M. and Van Loocke, W. and Gartlgruber, M. and Nunes, C. and De Vloed, F. and Depuydt, P. and Verboom, K. and Rombaut, D. and Loontiens, S. and De Wyn, J. and Kholosy, W.M. and Koopmans, B. and Essing, A.H.W. and Herrmann, C. and Dreidax, D. and Durinck, K. and Deforce, D. and van Nieuwerburgh, F. and Henssen, A. and Versteeg, R. and Boeva, V. and Schleiermacher, G. and van Nes, J. and Mestdagh, P. and Vanhauwaert, S. and Schulte, J.H. and Westermann, F. and Molenaar, J.J. and De Preter, K. and Speleman, F.
Nature Communications 9 (1): 4866. 19 November 2018

Nature Genetics

Disentangling extrachromosomal circular DNA heterogeneity in single cells with scEC&T-seq.
Chamorro González, R. and Henssen, A.G.
Nature Genetics 55 (5): 740-741. May 2023

Parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells.
Chamorro González, R. and Conrad, T. and Stöber, M.C. and Xu, R. and Giurgiu, M. and Rodriguez-Fos, E. and Kasack, K. and Brückner, L. and van Leen, E. and Helmsauer, K. and Dorado Garcia, H. and Stefanova, M.E. and Hung, K.L. and Bei, Y. and Schmelz, K. and Lodrini, M. and Mundlos, S. and Chang, H.Y. and Deubzer, H.E. and Sauer, S. and Eggert, A. and Schulte, J.H. and Schwarz, R.F. and Haase, K. and Koche, R.P. and Henssen, A.G.
Nature Genetics 55 (5): 880-890. May 2023

Targeted profiling of human extrachromosomal DNA by CRISPR-CATCH.
Hung, K.L. and Luebeck, J. and Dehkordi, S.R. and Colón, C.I. and Li, R. and Wong, I.T.L. and Coruh, C. and Dharanipragada, P. and Lomeli, S.H. and Weiser, N.E. and Moriceau, G. and Zhang, X. and Bailey, C. and Houlahan, K.E. and Yang, W. and González, R.C. and Swanton, C. and Curtis, C. and Jamal-Hanjani, M. and Henssen, A.G. and Law, J.A. and Greenleaf, W.J. and Lo, R.S. and Mischel, P.S. and Bafna, V. and Chang, H.Y.
Nature Genetics 54 (11): 1746–1754. November 2022

The evolutionary dynamics of extrachromosomal DNA in human cancers.
Lange, J.T. and Rose, J.C. and Chen, C.Y. and Pichugin, Y. and Xie, L. and Tang, J. and Hung, K.L. and Yost, K.E. and Shi, Q. and Erb, M.L. and Rajkumar, U. and Wu, S. and Taschner-Mandl, S. and Bernkopf, M. and Swanton, C. and Liu, Z. and Huang, W. and Chang, H.Y. and Bafna, V. and Henssen, A.G. and Werner, B. and Mischel, P.S.
Nature Genetics 54 (10): 1527-1533. October 2022

The genomic and spatial mobility of extrachromosomal DNA and its implications for cancer therapy.
van Leen, E. and Brückner, L. and Henssen, A.G.
Nature Genetics 54 (2): 107-114. February 2022

Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancers.
Kim, H. and Nguyen, N.P. and Turner, K. and Wu, S. and Gujar, A.D. and Luebeck, J. and Liu, J. and Deshpande, V. and Rajkumar, U. and Namburi, S. and Amin, S.B. and Yi, E. and Menghi, F. and Schulte, J.H. and Henssen, A.G. and Chang, H.Y. and Beck, C.R. and Mischel, .S. and Bafna, V. and Verhaak, R.G.W.
Nature Genetics 52 (9): 891-897. September 2020

Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma.
Koche, R.P. and Rodriguez-Fos, E. and Helmsauer, K. and Burkert, M. and MacArthur, I.C. and Maag, J. and Chamorro, R. and Munoz-Perez, N. and Puiggròs, M. and Dorado Garcia, H. and Bei, Y. and Röefzaad, C. and Bardinet, V. and Szymansky, A. and Winkler, A. and Thole, T. and Timme, N. and Kasack, K. and Fuchs, S. and Klironomos, F. and Thiessen, N. and Blanc, E. and Schmelz, K. and Künkele, A. and Hundsdörfer, P. and Rosswog, C. and Theissen, J. and Beule, D. and Deubzer, H. and Sauer, S. and Toedling, J. and Fischer, M. and Hertwig, F. and Schwarz, R.F. and Eggert, A. and Torrents, D. and Schulte, J.H. and Henssen, A.G.
Nature Genetics 52 (1): 29-34. January 2020

PGBD5 promotes site-specific oncogenic mutations in human tumors.
Henssen, A.G. and Koche, R. and Zhuang, J. and Jiang, E. and Reed, C. and Eisenberg, A. and Still, E. and MacArthur, I.C. and Rodriguez-Fos, E. and Gonzalez, S. and Puiggròs, M. and Blackford, A.N. and Mason, C.E. and de Stanchina, E. and Gönen, M. and Emde, A.K. and Shah, M. and Arora, K. and Reeves, C. and Socci, N.D. and Perlman, E. and Antonescu, C.R. and Roberts, C.W.M. and Steen, H. and Mullen, E. and Jackson, S.P. and Torrents, D. and Weng, Z. and Armstrong, S.A. and Kentsis, A.
Nature Genetics 49 (7): 1005-1014. July 2017

Mutational dynamics between primary and relapse neuroblastomas.
Schramm, A. and Köster, J. and Assenov, Y. and Althoff, K. and Peifer, M. and Mahlow, E. and Odersky, A. and Beisser, D. and Ernst, C. and Henssen, A.G. and Stephan, H. and Schröder, C. and Heukamp, L. and Engesser, A. and Kahlert, Y. and Theissen, J. and Hero, B. and Roels, F. and Altmüller, J. and Nürnberg, P. and Astrahantseff, K. and Gloeckner, C. and De Preter, K. and Plass, C. and Lee, S. and Lode, H.N. and Henrich, K.O. and Gartlgruber, M. and Speleman, F. and Schmezer, P. and Westermann, F. and Rahmann, S. and Fischer, M. and Eggert, A. and Schulte, J.H.
Nature Genetics 47 (8): 872-877. August 2015

Nature Reviews Genetics

Extrachromosomal DNA amplifications in cancer.
Yi, E. and Chamorro González, R. and Henssen, A.G. and Verhaak, R.G.W.
Nature Reviews Genetics 23 (12): 760-771. December 2022

Nucleic Acids Research

CORUM: the comprehensive resource of mammalian protein complexes-2022.
Tsitsiridis, G. and Steinkamp, R. and Giurgiu, M. and Brauner, B. and Fobo, G. and Frishman, G. and Montrone, C. and Ruepp, A.
Nucleic Acids Research 51 (D1): D539-D545. 6 January 2023

Oncotarget

Targeting tachykinin receptors in neuroblastoma.
Henssen, A.G. and Odersky, A. and Szymansky, A. and Seiler, M. and Althoff, K. and Beckers, A. and Speleman, F. and Schäfers, S. and De Preter, K. and Astrahanseff, K. and Struck, J. and Schramm, A. and Eggert, A. and Bergmann, A. and Schulte, J.H.
Oncotarget 8 (1): 430-443. 3 January 2017

BET bromodomain protein inhibition is a therapeutic option for medulloblastoma.
Henssen, A. and Thor, T. and Odersky, A. and Heukamp, L. and El-Hindy, N. and Beckers, A. and Speleman, F. and Althoff, K. and Schäfers, S. and Schramm, A. and Sure, U. and Fleischhack, G. and Eggert, A. and Schulte, J.H.
Oncotarget 4 (11): 2080-2095. November 2013

PLoS Computational Biology

Refphase: Multi-sample phasing reveals haplotype-specific copy number heterogeneity.
Watkins, T.B.K. and Colliver, E.C. and Huska, M.R. and Kaufmann, T.L. and Lim, E.L. and Duncan, C.B. and Haase, K. and Van Loo, P. and Swanton, C. and McGranahan, N. and Schwarz, R.F.
PLoS Computational Biology 19 (10): e1011379. 23 October 2023

Science Advances

Single-cell profiling of alveolar rhabdomyosarcoma reveals RAS pathway inhibitors as cell-fate hijackers with therapeutic relevance.
Danielli, S.G. and Porpiglia, E. and De Micheli, A.J. and Navarro, N. and Zellinger, M.J. and Bechtold, I. and Kisele, S. and Volken, L. and Marques, J.G. and Kasper, S. and Bode, P.K. and Henssen, A.G. and Gürgen, D. and Delattre, O. and Surdez, D. and Roma, J. and Bühlmann, P. and Blau, H.M. and Wachtel, M. and Schäfer, B.W.
Science Advances 9 (6): eade9238. 10 February 2023

Science Signaling

ALK pERKs up MYCN in neuroblastoma.
Lindner, S. and Henssen, A. and Astrahantseff, K. and Schulte, J.H.
Science Signaling 7 (349): pe27. 28 October 2014

Science Translational Medicine

Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors.
Henssen, A.G. and Reed, C. and Jiang, E. and Garcia, H.D. and von Stebut, J. and MacArthur, I.C. and Hundsdoerfer, P. and Kim, J.H. and de Stanchina, E. and Kuwahara, Y. and Hosoi, H. and Ganem, N.J. and Dela Cruz, F. and Kung, A.L. and Schulte, J.H. and Petrini, J.H. and Kentsis, A.
Science Translational Medicine 9 (414): eaam9078. 1 November 2017

Small Methods

CRISPR/Cas9 screen in gastric cancer patient-derived organoids reveals KDM1A-NDRG1 axis as a targetable vulnerability.
Mircetic, J. and Camgöz, A. and Abohawya, M. and Ding, L. and Dietzel, J. and Tobar, S.G. and Paszkowski-Rogacz, M. and Seidlitz, T. and Schmäche, T. and Mehnert, M.C. and Sidorova, O. and Weitz, J. and Buchholz, F. and Stange, D.E.
Small Methods 7 (6): e2201605. 20 June 2023

Translational Oncology

Small-molecule dual PLK1 and BRD4 inhibitors are active against preclinical models of pediatric solid tumors.
Timme, N. and Han, Y. and Liu, S. and Yosief, H.O. and García, H.D. and Bei, Y. and Klironomos, F. and MacArthur, I.C. and Szymansky, A. and von Stebut, J. and Bardinet, V. and Dohna, C. and Künkele, A. and Rolff, J. and Hundsdörfer, P. and Lissat, A. and Seifert, G. and Eggert, A. and Schulte, J.H. and Zhang, W. and Henssen, A.G.
Translational Oncology 13 (2): 221-232. February 2020

bioRxiv

Principles of ecDNA random inheritance drive rapid genome change and therapy resistance in human cancers.
Lange, J.T. and Chen, C.Y. and Pichugin, Y. and Xie, L. and Tang, J. and Hung, K.L. and Yost, K.E. and Shi, Q. and Erb, M.L. and Rajkumar, U. and Wu, S. and Swanton, C. and Liu, Z. and Huang, W. and Chang, H.Y. and Bafna, V. and Henssen, A.G. and Werner, B. and Mischel, P.S.
bioRxiv : 10.1101/2021.06.11.447968. 11 June 2021

Exploiting a PAX3-FOXO1-induced synthetic lethal ATR dependency for rhabdomyosarcoma therapy.
García, H.D. and Bei, Y. and von Stebut, J. and Ibáñez, G. and Imami, K. and Gürgen, D. and Rolff, J. and Helmsauer, K. and Timme, N. and Bardinet, V. and Chamorro González, R. and MacArthur, I.C. and Pusch, F.F. and Chen, C.Y. and Schulz, J. and Wengner, A.M. and Furth, C. and Lala, B. and Eggert, A. and Seifert, G. and Hundsoerfer, P. and Kirchner, M. and Mertins, P. and Selbach, M. and Lissat, A. and Schulte, J.H. and Haase, K. and Scheer, M. and Ortiz, M.V. and Henssen, A.G.
bioRxiv : 2020.12.04.411413. 2020

Enhancer hijacking determines intra- and extrachromosomal circular MYCN amplicon architecture in neuroblastoma.
Helmsauer, K. and Valieva, M. and Ali, S. and Chamorro González, R. and Schöpflin, R. and Röefzaad, C. and Bei, Y. and Garcia, H.D. and Rodriguez-Fos, E. and Puiggròs, M. and Kasack, K. and Haase, K. and Kuschel, L.P. and Euskirchen, P. and Heinrich, V. and Robson, M. and Rosswog, C. and Toedling, J. and Szymansky, A. and Hertwig, F. and Fischer, M. and Torrents, D. and Eggert, A. and Schulte, J.H. and Mundlos, S. and Henssen, A.G. and Koche, R.P.
bioRxiv : 2019.12.20.875807. 20 December 2019

Partner-independent fusion gene detection by multiplexed CRISPR/Cas9 enrichment and long-read Nanopore sequencing.
Stangl, C. and de Blank, S. and Renkens, I. and Verbeek, T. and Valle-Inclan, J.E. and Chamorro González, R. and Henssen, A.G. and van Roosmalen, M.J. and Stam, R.W. and Voest, E.E. and Kloosterman, W.P. and van Haaften, G. and Monroe, G.
bioRxiv : 807545. 22 October 2019

Prohibitin is a prognostic marker of relapse and therapeutic target to block chemotherapy resistance in Wilms tumor.
Ortiz, M.V. and Ahmed, S. and Burns, M. and Henssen, A.G. and Hollmann, T.J. and MacArthur, I. and Gunasekera, S. and Gaewsky, L. and Bradwin, G. and Ryan, J. and Letai, A. and He, Y. and Naranjo, A. and Chi, Y.Y. and LaQuaglia, M. and Heaton, T. and Cifani, P. and Dome, J.S. and Gadd, S. and Perlman, El. and Mullen, E. and Steen, H. and Kentsis, A.
bioRxiv : 508754. 30 December 2018

Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors.
Henssen, A.G. and Reed, Casie and Jiang, Eileen and Garcia, H.D. and von Stebut, J. and MacArthur, I.C. and Hundsdoerfer, P. and Kim, J.H. and de Stanchina, E. and Kuwahara, Y. and Hosoi, H. and Ganem, N. and Cruz, F.D. and Kung, A.L. and Schulte, J.H. and Petrini, J.H. and Kentsis, A.
bioRxiv : 181040. 25 August 2017

Human PGBD5 DNA transposase promotes site-specific oncogenic mutations in rhabdoid tumors.
Henssen, A.G. and Koche, R. and Zhuang, J. and Jiang, E. and Reed, C. and Eisenberg, A. and Still, E. and MacArthur, I.C. and Rodriguez-Fos, E. and Gonzalez, S. and Puiggròs, M. and Blackford, A.N. and Mason, C.E. and de Stanchina, E. and Gönen, M. and Emde, An.K. and Shah, M. and Arora, K. and Reeves, C. and Socci, N.D. and Perlman, E. and Antonescu, C.R. and Roberts, C.W.M. and Steen, H. and Mullen, E. and Jackson, S.P. and Torrents, D. and Weng, Z. and Armstrong, S.A. and Kentsis, A.
bioRxiv : 111138. 23 February 2017

Genomic DNA transposition induced by human PGBD5.
Henssen, A. and Henaff, E. and Jiang, E. and Eisenberg, A.R. and Carson, J.R. and Villasante, C. and Ray, M. and Still, E. and Burns, M. and Gandara, J. and Feschotte, C. and Mason, C.E. and Kentsis, A.
bioRxiv : 023887. 3 August 2015

eLife

Genomic DNA transposition induced by human PGBD5.
Henssen, A.G. and Henaff, E. and Jiang, E. and Eisenberg, A.R. and Carson, J.R. and Villasante, C.M. and Ray, M. and Still, E. and Burns, M. and Gandara, J. and Feschotte, C. and Mason, C.E. and Kentsis, A.
eLife 4 : e10565. 25 September 2015

This list was generated on Thu Apr 25 02:21:14 2024 CEST.