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| Item Type: | Review |
|---|---|
| Title: | A recipe for chaos: extrachromosomal DNA and the hallmarks of cancer |
| Creators Name: | Wong, Ivy Tsz-Lo, Bailey, Chris, Wu, Sihan, Henssen, Anton G., Cravatt, Benjamin F., Chen, Zhijian J., Bafna, Vineet, Jamal-Hanjani, Mariam, Swanton, Charlie, Chang, Howard Y. and Mischel, Paul S. |
| Abstract: | Some aggressive cancers exhibit a level of rapid genome change and therapy resistance that is difficult to explain. Research over the past decade has shown that extrachromosomal DNA (ecDNA) can be the cause. When oncogenic genetic elements untether from chromosomes and no longer follow Mendelian inheritance, genomic chaos and accelerated evolution ensue, generating unique ecDNA biology and non-traditional therapeutic vulnerabilities distinct from traditional mutation-targeting approaches. Here, we put forward a holistic view where ecDNA is integrated into the broader Hallmarks of Cancer framework to better understand the problem and chart a path forward. |
| Keywords: | DNA, Mutation, Neoplasms, Animals |
| Source: | Cell |
| ISSN: | 0092-8674 |
| Publisher: | Cell Press |
| Volume: | 189 |
| Number: | 8 |
| Page Range: | 2307-2321 |
| Date: | 16 April 2026 |
| Official Publication: | https://doi.org/10.1016/j.cell.2026.03.011 |
| PubMed: | View item in PubMed |
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