![[feed]](/style/images/feed-icon-14x14.png){kind=icon}
Tools
Tools
Preview |
PDF (Preprint)
- Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
3MB |
Preview |
PDF (Supplementary Material)
- Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
2MB |
| Item Type: | Preprint |
|---|---|
| Title: | TOPAS: phosphoproteome data analysis and decision support platform for molecular tumor boards |
| Creators: |
Jensen, Cecilia Bang, Sakhteman, Amirhossein, Hamood, Firas, Schneider, Annika, Woortman, Julia, Teleanu, Maria-Veronica, Horak, Peter, Bayer, Florian P., Stange, Christoph, Huellein, Jennifer, Hübschmann, Daniel, Henssen, Anton G.  ORCID: https://orcid.org/0000-0003-1534-778X, Fröhling, Stefan, Kuster, Bernhard and The, Matthew
|
| Abstract: | The molecular tumor board (MTB) is central to precision oncology, providing personalized treatment recommendations based on molecular profiles of patient tumors. Genomics is instrumental for MTBs but often fails to identify clinically actionable targets, a gap that phosphoproteomics can fill. We present the tumor proteome activity status (TOPAS) platform, an end-to-end analysis pipeline that converts terabytes of phosphoproteomic data into patient-specific reports for MTB discussions, focusing on clinically relevant signaling linked to oncogenic mechanisms and therapeutic targets. Designed to scale with growing cohorts, the platform integrates data from 1,998 tumor samples to support patient- and cohort-level hypothesis generation. A web portal handles quality control, calculates TOPAS scores, identifies tumor antigens and immune checkpoints, and offers interactive analyses of differential protein abundance and outlier detection. The TOPAS platform is open source, addresses a critical unmet need and facilitates broader adoption of phosphoproteomics in precision oncology in the future. |
| Source: | bioRxiv |
| Publisher: | Cold Spring Harbor Laboratory Press |
| Article Number: | 2026.07.08.737143 |
| Date: | 13 July 2026 |
| Additional Information: | The project PXD061316 is not public. |
| Official Publication: | https://doi.org/10.64898/2026.07.08.737143 |
| Related to: |
Repository Staff Only: item control page
