2026

Accurate prediction of ecDNA in interphase cancer cells using deep neural networks.
Prasad, Gino, Rajkumar, Utkrisht, Curtis, Ellis J., Wong, Ivy Tsz-Lo, Yan, Xiaowei, Zhang, Shu, Brückner, Lotte ORCID: https://orcid.org/0000-0002-6155-2277, Turner, Kristen, Wiese, Julie, Wahl, Justin, Hemmati, Homa, Wu, Sihan, Theissen, Jessica, Fischer, Matthias, Chang, Howard Y., Henssen, Anton G. ORCID: https://orcid.org/0000-0003-1534-778X, Mischel, Paul S. and Bafna, Vineet
Communications Biology 9 (1): 805. 15 June 2026

A recipe for chaos: extrachromosomal DNA and the hallmarks of cancer.
Wong, Ivy Tsz-Lo, Bailey, Chris, Wu, Sihan, Henssen, Anton G. ORCID: https://orcid.org/0000-0003-1534-778X, Cravatt, Benjamin F., Chen, Zhijian J., Bafna, Vineet, Jamal-Hanjani, Mariam, Swanton, Charlie, Chang, Howard Y. and Mischel, Paul S.
Cell 189 (8): 2307-2321. 16 April 2026

Extrachromosomal DNA associates with poor survival across a broad spectrum of childhood solid tumors.
Chapman, Owen S. ORCID: https://orcid.org/0000-0001-7923-9273, Sridhar, Sunita, Chow, Eugene Yui-Ching, Kenkre, Rishaan, Kirkland, Jonathan, Dutta, Aditi, Wang, Shanqing, Goto, Riki, Zhang, Wenshu, Brown, Miguel, Luebeck, Jens S. ORCID: https://orcid.org/0000-0003-4391-979X, Hui, Hui, Wang, Jessica, Lo, Yan Yuen, Rodriguez-Fos, Elias ORCID: https://orcid.org/0000-0002-2555-0178, Wang, Shanzheng, Okonechnikov, Konstantin ORCID: https://orcid.org/0000-0002-3409-2340, Ghasemi, David R., Pajtler, Kristian W., Gojo, Johannes, Henssen, Anton G. ORCID: https://orcid.org/0000-0003-1534-778X, Kool, Marcel, Bafna, Vineet ORCID: https://orcid.org/0000-0002-5810-6241, Kawauchi, Daisuke, Paul, Megan, Yip, Kevin, Mesirov, Jill P. and Chavez, Lukas
medRxiv : 2025.07.22.24308163v3. 9 April 2026

Mutated FGFR1 is an oncogenic driver and therapeutic target in high-risk neuroblastoma.
Werr, Lisa, Boland, Jana, Petersen, Josephine, Iglesias, Fiorella, Höppner, Stefanie, Bartenhagen, Christoph, Rosswog, Carolina, Hellmann, Anna-Maria, Kahlert, Yvonne, Hemstedt, Nadine, Ibruli, Nadliv, Dammert, Marcel A., Decarolis, Boris, Werner, Jan-Michael, Malchers, Florian, Schramm, Kathrin, Witt, Olaf, Beiske, Klaus Hermann, Rognlien, Anne Gro Wesenberg, Gunnes, Maria Winther, Langenberg, Karin Ps, Molenaar, Jan, Bernkopf, Marie, Taschner-Mandl, Sabine, Hughes, Debbie, George, Sally L., Chesler, Louis, Schulte, Johannes H., Barone, Giuseppe, Capasso, Mario, Surrey, Lea F., Bagatell, Rochelle, Masliah-Planchon, Julien, Schleiermacher, Gudrun, Grüll, Holger, Westermann, Frank, Schultheis, Anne M., Büttner, Reinhard, Henssen, Anton G. ORCID: https://orcid.org/0000-0003-1534-778X, Eggert, Angelika, Peifer, Martin, Shukla, Neerav N., Simon, Thorsten, Hero, Barbara, Reinhardt, H. Christian, Thomas, Roman K. and Fischer, Matthias
Journal of Clinical Investigation 136 (7): e189152. 1 April 2026

Combinatorial tumor suppressor gene targeting immortalizes primary pancreatic ductal cells, resulting in temporal, deterministic structural patterns across the genome.
Felsenstein, Matthäus, Hu, Mengwen, Ma, Dou, Tamboli, Jenny, Jin, Cao Zhong Jing, Wang, Ruonan, Hui, Luan Xiao, Dubois, Frank ORCID: https://orcid.org/0000-0002-7654-6208, Neumann, Christopher, Dolnik, Anna, Hillebrandt, Karl Herbert, Haderer, Luna, Giurgiu, Madalina ORCID: https://orcid.org/0000-0001-5007-7442, Henssen, Anton ORCID: https://orcid.org/0000-0003-1534-778X, Kübler, Kirsten, Pratschke, Johann, Malinka, Thomas, Sauer, Igor, Wood, Laura ORCID: https://orcid.org/0000-0003-3096-652X and Roberts, Nicholas ORCID: https://orcid.org/0000-0002-8709-0664
Research Square : rs-9124723/v1. 27 March 2026

Biological advances and current challenges for pediatric rhabdomyosarcoma.
Hebron, Katie E. ORCID: https://orcid.org/0000-0002-4740-8930, Odeniyide, Patience ORCID: https://orcid.org/0000-0002-9783-1657, Wei, Yun ORCID: https://orcid.org/0000-0003-2080-499X, Gryder, Berkley E. ORCID: https://orcid.org/0000-0003-0130-2302, Barr, Frederic G., Casey, Dana L., Chen, Eleanor Y. ORCID: https://orcid.org/0000-0003-4372-7560, Crompton, Brian D., Dela Cruz, Filemon S. ORCID: https://orcid.org/0000-0002-8356-5191, Durbin, Adam D. ORCID: https://orcid.org/0000-0002-5472-9847, Ford, Heide L., Gatz, Susanne A. ORCID: https://orcid.org/0000-0002-6438-9778, Hatley, Mark E. ORCID: https://orcid.org/0000-0001-7147-3946, Henssen, Anton G. ORCID: https://orcid.org/0000-0003-1534-778X, Hettmer, Simone ORCID: https://orcid.org/0000-0003-1709-4448, Houghton, Peter J., Kendall, Genevieve C. ORCID: https://orcid.org/0000-0003-3775-2006, Khan, Javed ORCID: https://orcid.org/0000-0002-5858-0488, Lupo, Philip J. ORCID: https://orcid.org/0000-0003-0978-5863, Patel, Anand G. ORCID: https://orcid.org/0000-0002-1438-8275, Pomella, Silvia ORCID: https://orcid.org/0000-0002-7007-4238, Rota, Rossella ORCID: https://orcid.org/0000-0002-9408-7711, Schito, Marco, Schoot, Reineke A., Shern, Jack F. ORCID: https://orcid.org/0000-0001-5579-7625, Stanton, Benjamin Z. ORCID: https://orcid.org/0000-0002-2613-2955, Stewart, Elizabeth A., Swindlehurst, Cathy A., Thomas, Craig J., Vakoc, Christopher R., Vaseva, Angelina V., Venkatramani, Rajkumar, Wexler, Leonard H., Yustein, Jason T., Hammond, Sharon, Heske, Christine M. ORCID: https://orcid.org/0000-0003-0956-6249, Langenau, David M., Linardic, Corinne M. ORCID: https://orcid.org/0000-0002-3257-2885, Ignatius, Myron S. and Yohe, Marielle E.
Cancers 18 (6): 888. March 2026

Number of affected lymph nodes predicts outcome in extremity rhabdomyosarcoma.
Margotte, Luna, Henssen, Anton ORCID: https://orcid.org/0000-0003-1534-778X, Thorwarth, Anne, Eggert, Angelika and Scheer, Monika ORCID: https://orcid.org/0000-0002-0665-6268
European Journal of Surgical Oncology 52 (3): 110535. March 2026

Extrachromosomal DNA micronucleation constrains tumour fitness and improves patient survival.
Brückner, L. ORCID: https://orcid.org/0000-0002-6155-2277, Xu, R. ORCID: https://orcid.org/0000-0002-5618-246X, Tang, J., Gnanasekar, A., Herrmann, A., Wong, I.T.L., Zhang, S., Tu, F., Pilon, M., Kukalev, A. ORCID: https://orcid.org/0000-0001-5847-3773, Pardon, K., Sidorova, O. ORCID: https://orcid.org/0009-0004-1459-1662, Atta, J., Yu, Q. ORCID: https://orcid.org/0000-0002-2151-9624, Montouri, G., Pradella, D., Ilić, M., Suina, K., Novais-Cruz, M., Kaltenbach, S., Treue, D., Giurgiu-Kraljič, M. ORCID: https://orcid.org/0000-0001-5007-7442, Herzog, S., Hollinger, A.S., Wittstruck, N., Fernandez, M., Wolozyn, N., Becker, F., Louma, V.R., Yan, X., Schmargon, R. ORCID: https://orcid.org/0009-0009-3535-7185, Dörr, J. ORCID: https://orcid.org/0000-0002-4927-6548, Gamlin, D., Lehmann, A., Gürgen, D. ORCID: https://orcid.org/0000-0001-9241-6537, Richter, M. ORCID: https://orcid.org/0000-0002-5339-0781, Dubois, F. ORCID: https://orcid.org/0000-0002-7654-6208, Simeoni, F., Pennycook, B.R., Hamilton, A., Lindemann, R.K., Dawes, C., Balmus, G., Hero, B., Fischer, M., Bafna, V., Verhaak, R., Wahl, G., Liu, Y., Koche, R.P., Papathanasiou, S., Medema, R., Spanjaard, B. ORCID: https://orcid.org/0000-0003-1309-8839, Ventura, A., Pombo, A. ORCID: https://orcid.org/0000-0002-7493-6288, Huang, W., Scheer, M., Werner, B., Chang, H.Y., Mischel, P.S. and Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X
bioRxiv : 2025.04.15.648906. 19 February 2026

Reconstructing the three-dimensional architecture of extrachromosomal DNA with ec3D.
Chowdhury, Biswanath, Zhu, Kaiyuan, Li, Chaohui, Alsing, Jessica, Luebeck, Jens ORCID: https://orcid.org/0000-0003-4391-979X, Stefanova, Maria E., Chapman, Owen S., Kraft, Katerina, Zhang, Shu, Lim, Jun Yi Stanley, Xie, Yipeng, Kim, Yoon Jung, Wu, Sihan, Chavez, Lukas, Nir, Guy, Henssen, Anton G. ORCID: https://orcid.org/0000-0003-1534-778X, Mischel, Paul S., Chang, Howard Y. and Bafna, Vineet
[Dataset] 24 January 2026

Reconstructing the three-dimensional architecture of extrachromosomal DNA with ec3D.
Chowdhury, Biswanath ORCID: https://orcid.org/0000-0003-3465-7505, Zhu, Kaiyuan ORCID: https://orcid.org/0000-0001-9976-6505, Li, Chaohui ORCID: https://orcid.org/0009-0009-6196-1191, Alsing, Jessica ORCID: https://orcid.org/0000-0002-8558-6471, Luebeck, Jens ORCID: https://orcid.org/0000-0003-4391-979X, Stefanova, Maria E., Chapman, Owen S., Kraft, Katerina, Zhang, Shu, Lim, Jun Yi Stanley, Xie, Yipeng, Kim, Yoon Jung, Wu, Sihan ORCID: https://orcid.org/0000-0001-8329-7492, Chavez, Lukas, Nir, Guy ORCID: https://orcid.org/0000-0001-9268-6596, Henssen, Anton G. ORCID: https://orcid.org/0000-0003-1534-778X, Mischel, Paul S. ORCID: https://orcid.org/0000-0002-4560-2211, Chang, Howard Y. ORCID: https://orcid.org/0000-0002-9459-4393 and Bafna, Vineet ORCID: https://orcid.org/0000-0002-5810-6241
Nature Communications 17 (1): 894. 23 January 2026

Genetic elements promote retention of extrachromosomal DNA in cancer cells.
Sankar, Venkat, Hung, King L., Gnanasekar, Aditi, Wong, Ivy Tsz-Lo ORCID: https://orcid.org/0000-0002-9761-3422, Shi, Quanming, Kraft, Katerina, Jones, Matthew G., He, Britney Jiayu, Yan, Xiaowei ORCID: https://orcid.org/0000-0002-4846-8812, Belk, Julia A. ORCID: https://orcid.org/0000-0003-4724-6158, Liu, Kevin J. ORCID: https://orcid.org/0000-0003-3836-3213, Agarwal, Sangya ORCID: https://orcid.org/0000-0003-4272-515X, Wang, Sean K. ORCID: https://orcid.org/0000-0003-1557-8510, Henssen, Anton G. ORCID: https://orcid.org/0000-0003-1534-778X, Mischel, Paul S. ORCID: https://orcid.org/0000-0002-4560-2211 and Chang, Howard Y. ORCID: https://orcid.org/0000-0002-9459-4393
Nature 649 (8095): 152-160. 1 January 2026

Pathway for the development of ATR inhibitors in pediatric malignancies: an ACCELERATE multistakeholder analysis.
Gatz, Susanne A. ORCID: https://orcid.org/0000-0002-6438-9778, Glade-Bender, Julia ORCID: https://orcid.org/0000-0001-5316-6440, Pearson, Andrew D.J. ORCID: https://orcid.org/0000-0002-8738-5913, Ortiz, Michael V. ORCID: https://orcid.org/0000-0001-9379-314X, Bernardi, Ronald, Chesler, Lou ORCID: https://orcid.org/0000-0001-7842-2068, Clifford, Steve ORCID: https://orcid.org/0000-0002-8573-8009, Cohen-Gogo, Sarah ORCID: https://orcid.org/0000-0002-8852-1104, De La Cuesta, Esther ORCID: https://orcid.org/0000-0001-7072-1493, de Rojas, Teresa ORCID: https://orcid.org/0000-0001-7749-8423, Durinck, Kaat ORCID: https://orcid.org/0000-0003-1762-5739, Federico, Sara ORCID: https://orcid.org/0000-0002-5807-4876, Fox, Elizabeth ORCID: https://orcid.org/0000-0002-9998-5326, George, Sally ORCID: https://orcid.org/0000-0003-2777-4922, Gounaris, Ioannis ORCID: https://orcid.org/0000-0003-2755-6597, Henssen, Anton George ORCID: https://orcid.org/0000-0003-1534-778X, Irwin, Meredith ORCID: https://orcid.org/0000-0002-2452-5181, Kool, Marcel, Lau, Alan ORCID: https://orcid.org/0000-0003-1055-9812, Nysom, Karsten ORCID: https://orcid.org/0000-0003-2935-0058, Pappo, Alberto ORCID: https://orcid.org/0000-0002-5338-3979, Pennock, Gregory K., Pfister, Stefan M., Scobie, Nicole ORCID: https://orcid.org/0000-0002-6539-2741, Slotkin, Emily K. ORCID: https://orcid.org/0000-0002-4463-5759, Smith, Malcolm ORCID: https://orcid.org/0000-0001-9880-9876, Speleman, Frank, Stewart, Elizabeth A., Weigel, Brenda J. ORCID: https://orcid.org/0000-0003-1080-1402 and Vassal, Gilles ORCID: https://orcid.org/0000-0003-1780-8869
JCO Precision Oncology 10 : e2500642. January 2026

2025

Personalized CRISPR knock-in cytokine gene therapy to remodel the tumor microenvironment and enhance CAR T cell therapy in solid tumors.
Launspach, Michael ORCID: https://orcid.org/0000-0001-5337-5605, Macos, Julia ORCID: https://orcid.org/0009-0008-9196-3975, Afzal, Shoaib ORCID: https://orcid.org/0009-0009-5490-6098, Hohmann, Janik ORCID: https://orcid.org/0009-0001-5374-1350, Appis, Marc L. ORCID: https://orcid.org/0000-0002-0155-1918, Pilgram, Maximilian ORCID: https://orcid.org/0009-0002-3423-5249, Beez, Stefanie, Ohlendorf, Emily, van der Ven, Casper F.T. ORCID: https://orcid.org/0000-0001-7947-6105, Lachiheb, Chahrazad, Töws, Karin, Andersch, Lena, Jens, Marvin ORCID: https://orcid.org/0000-0002-6660-8743, Zirngibl, Felix ORCID: https://orcid.org/0000-0003-1764-4841, Kath, Jonas ORCID: https://orcid.org/0000-0001-7721-7978, Stecklum, Maria ORCID: https://orcid.org/0009-0001-7951-5730, Rodriguez-Fos, Elias ORCID: https://orcid.org/0000-0002-2555-0178, Anders, Kathleen ORCID: https://orcid.org/0000-0002-0429-200X, Wagner, Dimitrios L. ORCID: https://orcid.org/0000-0002-2189-3579, Henssen, Anton G. ORCID: https://orcid.org/0000-0003-1534-778X, Kühn, Ralf ORCID: https://orcid.org/0000-0003-1694-9803, Eggert, Angelika and Künkele, Annette ORCID: https://orcid.org/0000-0002-8406-5412
Nature Communications 16 (1): 10987. 9 December 2025

Investigating genetic modifications to enhance L1CAM-CAR T cell migration in solid tumors in a 3D bioprinted neuroblastoma model.
Andersch, Lena, Grunewald, Laura, Stecklum, Maria, Klironomos, Filippos, Haase, Kerstin ORCID: https://orcid.org/0000-0002-0944-5618, Hollek, Viola, Lam, Tobias, Jung, Beate Anahita, Winkler, Anika, Schwiebert, Silke, Astrahantseff, Kathy, Launspach, Michael, Jens, Marvin ORCID: https://orcid.org/0000-0002-6660-8743, Henssen, Anton ORCID: https://orcid.org/0000-0003-1534-778X, Kloke, Lutz, Blüthgen, Nils ORCID: https://orcid.org/0000-0002-0171-7447, Eggert, Angelika, Schulte, Johannes H. ORCID: https://orcid.org/0000-0003-0671-1201, Anders, Kathleen ORCID: https://orcid.org/0000-0002-0429-200X and Künkele, Annette
Frontiers in Immunology 16 : 1677361. 27 November 2025

interSeg: accurate prediction of edDNA in interphase cancer cells using deep neural networks.
Prasad, Gino ORCID: https://orcid.org/0000-0003-4590-1278, Rajkumar, Utkrisht ORCID: https://orcid.org/0000-0002-2825-6310, Curtis, Ellis, Wong, Ivy ORCID: https://orcid.org/0000-0002-9761-3422, Yan, Xiaowei ORCID: https://orcid.org/0000-0002-4846-8812, Zhang, Shu ORCID: https://orcid.org/0000-0003-2543-5943, Brückner, Lotte ORCID: https://orcid.org/0000-0002-6155-2277, Turner, Kristen, Wiese, Julie, Wahl, Justin, Hemmati, Homa, Wu, Sihan ORCID: https://orcid.org/0000-0001-8329-7492, Theissen, Jessica, Fischer, Matthias, Chang, Howard ORCID: https://orcid.org/0000-0002-9459-4393, Henssen, Anton ORCID: https://orcid.org/0000-0003-1534-778X, Mischel, Paul ORCID: https://orcid.org/0000-0002-4560-2211 and Bafna, Vineet ORCID: https://orcid.org/0000-0002-5810-6241
[Dataset] 24 November 2025

Lineage origin and microenvironment shape neuroblastoma transcriptional state and plasticity.
Fresmann, Nora ORCID: https://orcid.org/0000-0002-9233-5101, Koeppke, Julia, Gauert, Anton ORCID: https://orcid.org/0000-0002-3013-5374, Senoussi, Anis ORCID: https://orcid.org/0000-0002-7066-8917, Olivares-Chauvet, Pedro ORCID: https://orcid.org/0009-0008-4684-255X, Schott, Marie ORCID: https://orcid.org/0009-0000-7393-2421, Hoefer, Lennart, Henssen, Anton G. ORCID: https://orcid.org/0000-0003-1534-778X, Rajewsky, Nikolaus ORCID: https://orcid.org/0000-0002-4785-4332, Spanjaard, Bastiaan ORCID: https://orcid.org/0000-0003-1309-8839, Hagemann, Anja I.H. ORCID: https://orcid.org/0000-0001-5491-4607 and Junker, Jan Philipp ORCID: https://orcid.org/0000-0002-2826-8290
bioRxiv : 2025.10.13.682025. 14 October 2025

Extrachromosomal DNA-driven oncogene dosage heterogeneity promotes rapid adaptation to therapy in MYCN-amplified cancers.
Montuori, Giulia, Tu, Fengyu, Qin, Di ORCID: https://orcid.org/0000-0002-9730-4072, Schmargon, Rachel ORCID: https://orcid.org/0009-0009-3535-7185, Rodriguez-Fos, Elias ORCID: https://orcid.org/0000-0002-2555-0178, Helmsauer, Konstantin ORCID: https://orcid.org/0000-0003-0773-4114, Hui, Hui, Mandal, Susmita, Purshouse, Karin, Fankhänel, Lara, Bosco, Bartolomeo ORCID: https://orcid.org/0000-0002-3069-714X, Spanjaard, Bastiaan ORCID: https://orcid.org/0000-0003-1309-8839, Seyboldt, Hannah, Grunewald, Laura, Schmitt, Matthias Jürgen ORCID: https://orcid.org/0000-0001-8296-5858, Gürgen, Dennis, Buck, Viktoria, Rosenfeldt, Mathias T, Dubois, Frank P.B. ORCID: https://orcid.org/0000-0002-7654-6208, Schallenberg, Simon, Lehmann, Annika, Theißen, Jessica, Taschner-Mandl, Sabine, Koch, Arend, Hundsdoerfer, Patrick, Künkele, Annette, Eggert, Angelika, Fischer, Matthias, Gargiulo, Gaetano ORCID: https://orcid.org/0000-0001-5414-4251, Krieger, Teresa G, Chavez, Lukas, Coscia, Fabian ORCID: https://orcid.org/0000-0002-2244-5081, Werner, Benjamin, Huang, Weini, Henssen, Anton G. ORCID: https://orcid.org/0000-0003-1534-778X and Dörr, Jan R. ORCID: https://orcid.org/0000-0002-4927-6548
Cancer Discovery 15 (10): 2054-2077. 6 October 2025

Extrachromosomal circular DNA promotes inflammation and hepatocellular carcinoma development.
Chan, Lap Kwan ORCID: https://orcid.org/0000-0002-9165-6982, Shan, Juanjuan ORCID: https://orcid.org/0000-0002-0640-1652, Rodriguez-Fos, Elias ORCID: https://orcid.org/0000-0002-2555-0178, Healy, Marc Eamonn ORCID: https://orcid.org/0000-0001-9441-1166, Leary, Peter ORCID: https://orcid.org/0000-0003-1430-6185, Parrotta, Rossella, Desboeufs, Nina ORCID: https://orcid.org/0009-0007-0883-579X, Semere, Gabriel, Wittstruck, Nadine ORCID: https://orcid.org/0009-0000-4378-3226, Henssen, Anton G. ORCID: https://orcid.org/0000-0003-1534-778X and Weber, Achim ORCID: https://orcid.org/0000-0003-0073-3637
Science Advances 11 (42): eadw0272. October 2025

Aberrant inheritance of extrachromosomal DNA amplifications promotes cancer evolution.
Marom, Shir, Lifshits Dayan, Inbar, Narasimha Kadali, Venkata, Giurgiu-Kraljič, Mădălina ORCID: https://orcid.org/0000-0001-5007-7442, Koifman, Gabriela ORCID: https://orcid.org/0000-0002-7728-5214, Hakeny, Karen, Chaurasia, Madhuri, Benamozig, Orlena, Nevo, Reinat ORCID: https://orcid.org/0009-0000-3327-4022, Azuri, Ido ORCID: https://orcid.org/0000-0002-2891-1514, Ryvkin, Julia ORCID: https://orcid.org/0000-0002-1172-8350, Rotkopf, Ron ORCID: https://orcid.org/0000-0001-9503-7348, Stelzer, Gil ORCID: https://orcid.org/0000-0001-9368-4912, Oniashvili, Nino, Mardoukh, Jacques, Pollock, Sarah, Iremadze, Nika, Shipony, Zohar ORCID: https://orcid.org/0000-0003-2110-8822, Kupervaser, Meital ORCID: https://orcid.org/0000-0002-1068-937X, Wigoda, Noa ORCID: https://orcid.org/0000-0002-4496-881X, Leshkowitz, Dena ORCID: https://orcid.org/0000-0002-4703-2830, Elazar, Zvulun ORCID: https://orcid.org/0000-0002-3231-4464, Berko, Esther ORCID: https://orcid.org/0000-0001-7181-1378, Henssen, Anton G. ORCID: https://orcid.org/0000-0003-1534-778X and Shoshani, Ofer ORCID: https://orcid.org/0000-0001-8918-9935
bioRxiv : 2025.09.19.677276. 21 September 2025

Selective depletion of cancer cells with extrachromosomal DNA via lentiviral infection.
Yi, Eunhee, Gujar, Amit D., Zhao, Dacheng, Suina, Kentaro, Jin, Xue, Pardon, Katharina, Yu, Qinghao ORCID: https://orcid.org/0000-0002-2151-9624, Kagermazova, Larisa, Korsah, Emmanuel E., Dusseau, Noah A., Boeke, Jef D., Henssen, Anton G. ORCID: https://orcid.org/0000-0003-1534-778X and Verhaak, Roel G.W.
Cancer Research Communications 5 (8): 1458-1465. August 2025

Spatial-temporal diversity of extrachromosomal DNA shapes urothelial carcinoma evolution and tumor-immune microenvironment.
Lv, W. ORCID: https://orcid.org/0009-0004-0820-8620, Zeng, Y. ORCID: https://orcid.org/0000-0001-5873-5948, Li, C. ORCID: https://orcid.org/0000-0002-1540-8231, Liang, Y. ORCID: https://orcid.org/0000-0003-3535-3394, Tao, H. ORCID: https://orcid.org/0009-0000-5463-9633, Zhu, Y. ORCID: https://orcid.org/0000-0003-2310-5545, Sui, X. ORCID: https://orcid.org/0000-0001-7004-1973, Li, Y. ORCID: https://orcid.org/0009-0009-6031-518X, Jiang, S. ORCID: https://orcid.org/0009-0006-2889-9697, Gao, Q. ORCID: https://orcid.org/0009-0004-6381-9432, Rodriguez-Fos, E. ORCID: https://orcid.org/0000-0002-2555-0178, Prasad, G. ORCID: https://orcid.org/0000-0003-4590-1278, Wang, Y. ORCID: https://orcid.org/0000-0002-0068-5148, Zhou, R. ORCID: https://orcid.org/0000-0003-3485-8294, Xu, Z. ORCID: https://orcid.org/0000-0002-8999-3234, Pan, X. ORCID: https://orcid.org/0000-0002-2688-9245, Chen, L. ORCID: https://orcid.org/0009-0000-5602-4704, Xiang, X. ORCID: https://orcid.org/0000-0002-5590-7289, Teng, H. ORCID: https://orcid.org/0000-0001-9952-3618, Sun, C. ORCID: https://orcid.org/0000-0003-2469-1638, Qin, T. ORCID: https://orcid.org/0000-0002-5897-871X, Dong, W. ORCID: https://orcid.org/0000-0001-6386-0831, Li, Y. ORCID: https://orcid.org/0000-0002-4843-5447, Lan, X. ORCID: https://orcid.org/0000-0002-6523-046X, Li, X. ORCID: https://orcid.org/0000-0002-7030-0856, Lin, L. ORCID: https://orcid.org/0000-0002-7546-4948, Bolund, L. ORCID: https://orcid.org/0009-0005-5995-8197, Yang, H. ORCID: https://orcid.org/0000-0002-0858-3410, Verhaak, R.G.W. ORCID: https://orcid.org/0000-0003-2773-0436, Faltas, B.M. ORCID: https://orcid.org/0000-0002-6432-1693, Hansen, J.B. ORCID: https://orcid.org/0000-0001-5249-2586, Wu, S. ORCID: https://orcid.org/0000-0001-8329-7492, Mischel, P.S. ORCID: https://orcid.org/0000-0002-4560-2211, Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X, Bafna, V. ORCID: https://orcid.org/0000-0002-5810-6241, Luebeck, J. ORCID: https://orcid.org/0000-0003-4391-979X, Regenberg, B. ORCID: https://orcid.org/0000-0003-4996-7012, Luo, Y. ORCID: https://orcid.org/0000-0002-0007-7759, Lin, C. ORCID: https://orcid.org/0000-0001-5225-3518 and Han, P. ORCID: https://orcid.org/0000-0002-3405-087X
Cancer Discovery 15 (6): 1225-1246. 3 June 2025

Supplementary Tables 1-24 from Spatial–Temporal Diversity of Extrachromosomal DNA Shapes Urothelial Carcinoma Evolution and the Tumor Immune Microenvironment.
Lv, Wei, Zeng, Yuche, Li, Conghui, Liang, Yuan, Tao, Huiying, Zhu, Yanfen, Sui, Xiaolong, Li, Yue, Jiang, Shiqi, Gao, Qingqing, Rodriguez-Fos, Elias ORCID: https://orcid.org/0000-0002-2555-0178, Prasad, Gino, Wang, Yuanmei, Zhou, Run, Xu, Zhe, Pan, Xiaoguang, Chen, Linlin, Xiang, Xi, Teng, Huajing, Sun, Chaoyang, Li, Wei, Qin, Tianyu, Dong, Wei, Li, Yongwei, Lan, Xun, Li, Xuesong, Lin, Lin, Bolund, Lars, Yang, Huanming, Verhaak, Roel G.W., Faltas, Bishoy M., Hansen, Jacob B., Wu, Sihan, Mischel, Paul S., Henssen, Anton G. ORCID: https://orcid.org/0000-0003-1534-778X, Bafna, Vineet, Luebeck, Jens, Regenberg, Birgitte, Luo, Yonglun, Lin, Chunhua and Han, Peng
[Dataset] 3 June 2025

Chromothripsis-associated chromosome 21 amplification orchestrates transformation to blast-phase MPN through targetable overexpression of DYRK1A.
Brierley, C.K. ORCID: https://orcid.org/0000-0002-4028-3733, Yip, B.H., Orlando, G., Wen, J., Wen, S., Goyal, H., Levine, M. ORCID: https://orcid.org/0000-0001-5156-9086, Jakobsdottir, G.M. ORCID: https://orcid.org/0000-0001-8225-6541, Tapinos, A., Cornish, A.J. ORCID: https://orcid.org/0000-0002-3966-3501, Rodriguez-Romera, A. ORCID: https://orcid.org/0000-0001-7193-9144, Rodriguez-Meira, A., Bashton, M., Hamblin, A., Clark, S.A., Hamley, J.C., Fox, O., Giurgiu, M. ORCID: https://orcid.org/0000-0001-5007-7442, O'Sullivan, J., Murphy, L., Adamo, A., Olijnik, A.A. ORCID: https://orcid.org/0000-0002-0980-6663, Cotton, A., Hendrix, E. ORCID: https://orcid.org/0009-0006-0514-3918, Narina, S. ORCID: https://orcid.org/0000-0002-9952-1302, Pruett-Miller, S.M. ORCID: https://orcid.org/0000-0002-3793-585X, Enshaei, A. ORCID: https://orcid.org/0000-0002-7464-0743, Harrison, C. ORCID: https://orcid.org/0000-0002-3212-920X, Drummond, M., Knapper, S., Tefferi, A., Antony-Debré, I. ORCID: https://orcid.org/0000-0002-1911-146X, Davies, J. ORCID: https://orcid.org/0000-0002-4108-4357, Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X, Thongjuea, S., Wedge, D.C. ORCID: https://orcid.org/0000-0002-7572-3196, Constantinescu, S.N., Papaemmanuil, E. ORCID: https://orcid.org/0000-0003-1709-8983, Psaila, B. ORCID: https://orcid.org/0000-0001-8198-9663, Crispino, J.D. ORCID: https://orcid.org/0000-0002-8182-8306 and Mead, A.J. ORCID: https://orcid.org/0000-0001-8522-1002
Nature Genetics 57 (6): 1478-1492. June 2025

Rhabdomyosarcoma of head and neck varies in aggressiveness depending on the specific site of origin.
Rohde, J., Henssen, A. ORCID: https://orcid.org/0000-0003-1534-778X, Eggert, A. and Scheer, M. ORCID: https://orcid.org/0000-0002-0665-6268
Oral Oncology 164 : 107263. May 2025

Targeting MYCN upregulates L1CAM tumor antigen in MYCN-dysregulated neuroblastoma to increase CAR T cell efficacy.
Grunewald, L. ORCID: https://orcid.org/0000-0002-7175-7380, Andersch, L., Helmsauer, K. ORCID: https://orcid.org/0000-0003-0773-4114, Schwiebert, S., Klaus, A., Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X, Straka, T., Lodrini, M., Wicha, S.G., Fuchs, S., Hertwig, F. ORCID: https://orcid.org/0000-0003-4784-6516, Westermann, F., Vitali, A., Caramel, C., Büchel, G., Eilers, M., Astrahantseff, K., Eggert, A., Höpken, U.E. ORCID: https://orcid.org/0000-0002-0776-4893, Schulte, J.H. ORCID: https://orcid.org/0000-0003-0671-1201, Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321, Anders, K. ORCID: https://orcid.org/0000-0002-0429-200X and Künkele, A.
Pharmacological Research 212 : 107608. February 2025

Serially quantifying TERT rearrangement breakpoints in circulating tumor DNA enables minimal residual disease monitoring in patients with neuroblastoma.
Hollander, J.F. ORCID: https://orcid.org/0009-0001-2907-2206, Szymansky, A. ORCID: https://orcid.org/0000-0003-4797-4526, Wünschel, J. ORCID: https://orcid.org/0009-0007-5658-7532, Astrahantseff, K. ORCID: https://orcid.org/0000-0002-7872-1997, Rosswog, C. ORCID: https://orcid.org/0000-0002-8855-6198, Thorwarth, A. ORCID: https://orcid.org/0000-0001-6290-9963, Thole-Kliesch, T.M. ORCID: https://orcid.org/0000-0003-2714-6221, Chamorro Gonzalez, R. ORCID: https://orcid.org/0000-0002-5653-7259, Hundsdörfer, P. ORCID: https://orcid.org/0009-0007-1158-5170, Hauptmann, K. ORCID: https://orcid.org/0000-0003-0590-3674, Schmelz, K. ORCID: https://orcid.org/0009-0009-6954-9927, Gürgen, D. ORCID: https://orcid.org/0000-0001-9241-6537, Rogasch, J.M.M. ORCID: https://orcid.org/0000-0002-0817-6532, Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X, Fischer, M. ORCID: https://orcid.org/0000-0003-1363-1242, Schulte, J.H. ORCID: https://orcid.org/0000-0003-0671-1201, Eckert, C. ORCID: https://orcid.org/0000-0003-1039-2872, Eggert, A. ORCID: https://orcid.org/0000-0003-3476-8184, Lodrini, M. ORCID: https://orcid.org/0000-0003-4434-529X and Deubzer, H.E. ORCID: https://orcid.org/0000-0002-6115-4893
Cancer Research Communications 5 (1): 167-177. 28 January 2025

2024

Coordinated inheritance of extrachromosomal DNAs in cancer cells.
Hung, K.L. ORCID: https://orcid.org/0000-0002-3662-4662, Jones, M.G., Wong, I.T.L. ORCID: https://orcid.org/0000-0002-9761-3422, Curtis, E.J., Lange, J.T., He, B.J. ORCID: https://orcid.org/0000-0001-8989-1521, Luebeck, J. ORCID: https://orcid.org/0000-0003-4391-979X, Schmargon, R. ORCID: https://orcid.org/0009-0009-3535-7185, Scanu, E., Brückner, L. ORCID: https://orcid.org/0000-0002-6155-2277, Yan, X. ORCID: https://orcid.org/0000-0002-4846-8812, Li, R. ORCID: https://orcid.org/0000-0002-3085-5267, Gnanasekar, A., Chamorro González, R. ORCID: https://orcid.org/0000-0002-5653-7259, Belk, J.A. ORCID: https://orcid.org/0000-0003-4724-6158, Liu, Z., Melillo, B. ORCID: https://orcid.org/0000-0002-9708-5287, Bafna, V., Dörr, J.R. ORCID: https://orcid.org/0000-0002-4927-6548, Werner, B. ORCID: https://orcid.org/0000-0002-6857-8699, Huang, W. ORCID: https://orcid.org/0000-0002-9016-2665, Cravatt, B.F. ORCID: https://orcid.org/0000-0001-5330-3492, Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X, Mischel, P.S ORCID: https://orcid.org/0000-0002-4560-2211 and Chang, H.Y. ORCID: https://orcid.org/0000-0002-9459-4393
Nature 635 (8037): 201-209. 7 November 2024

The other site of rhabdomyosarcoma.
Kern, L., Henssen, A. ORCID: https://orcid.org/0000-0003-1534-778X, Eggert, A. and Scheer, M. ORCID: https://orcid.org/0000-0002-0665-6268
Cancer Medicine 13 (20): e70348. October 2024

Intercellular extrachromosomal DNA copy-number heterogeneity drives neuroblastoma cell state diversity.
Stöber, M.C., Chamorro González, R. ORCID: https://orcid.org/0000-0002-5653-7259, Brückner, L. ORCID: https://orcid.org/0000-0002-6155-2277, Conrad, T. ORCID: https://orcid.org/0000-0001-5618-6295, Wittstruck, N. ORCID: https://orcid.org/0009-0000-4378-3226, Szymansky, A. ORCID: https://orcid.org/0000-0003-4797-4526, Eggert, A., Schulte, J.H. ORCID: https://orcid.org/0000-0003-0671-1201, Koche, R.P., Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X, Schwarz, R.F. ORCID: https://orcid.org/0000-0001-9155-4268 and Haase, K. ORCID: https://orcid.org/0000-0002-0944-5618
Cell Reports 43 (9): 114711. 24 September 2024

10X single-nuclei RNA sequencing.
Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X
[Dataset] 16 September 2024

Genomic and Transcriptomic sequencing of neuroblastoma cell lines.
Henssen, Anton G. ORCID: https://orcid.org/0000-0003-1534-778X
[Dataset] 16 September 2024

Genomic and Transcriptomic sequencing of neuroblastoma patient.
Henssen, Anton G. ORCID: https://orcid.org/0000-0003-1534-778X
[Dataset] 16 September 2024

Reconstructing extrachromosomal DNA structural heterogeneity from long-read sequencing data using Decoil.
Giurgiu, M. ORCID: https://orcid.org/0000-0001-5007-7442, Wittstruck, N. ORCID: https://orcid.org/0009-0000-4378-3226, Rodriguez-Fos, E. ORCID: https://orcid.org/0000-0002-2555-0178, Chamorro González, R. ORCID: https://orcid.org/0000-0002-5653-7259, Brückner, L. ORCID: https://orcid.org/0000-0002-6155-2277, Krienelke-Szymansky, A. ORCID: https://orcid.org/0000-0003-4797-4526, Helmsauer, K. ORCID: https://orcid.org/0000-0003-0773-4114, Hartebrodt, A., Euskirchen, P. ORCID: https://orcid.org/0000-0002-9138-805X, Koche, R.P., Haase, K. ORCID: https://orcid.org/0000-0002-0944-5618, Reinert, K. and Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X
Genome Research 34 (9): 1355-1364. September 2024

Decoil: reconstructing extrachromosomal DNA structural heterogeneity from long-read sequencing data.
Giurgiu, M. ORCID: https://orcid.org/0000-0001-5007-7442, Wittstruck, N. ORCID: https://orcid.org/0009-0000-4378-3226, Rodriguez-Fos, E. ORCID: https://orcid.org/0000-0002-2555-0178, Chamorro González, R. ORCID: https://orcid.org/0000-0002-5653-7259, Brückner, L. ORCID: https://orcid.org/0000-0002-6155-2277, Krienelke-Szymansky, A. ORCID: https://orcid.org/0000-0003-4797-4526, Helmsauer, K. ORCID: https://orcid.org/0000-0003-0773-4114, Hartebrodt, A. ORCID: https://orcid.org/0000-0002-9172-3137, Euskirchen, P. ORCID: https://orcid.org/0000-0002-9138-805X, Koche, R.P. ORCID: https://orcid.org/0000-0002-6820-5083, Haase, K. ORCID: https://orcid.org/0000-0002-0944-5618, Reinert, K. ORCID: https://orcid.org/0000-0003-3078-8129 and Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X
Lecture Notes in Computer Science 14758 : 406-411. 17 May 2024

Elimusertib has antitumor activity in preclinical patient-derived pediatric solid tumor models.
Pusch, F.F. ORCID: https://orcid.org/0000-0002-7152-080X, Dorado Garcia, H. ORCID: https://orcid.org/0000-0002-2578-3350, Xu, R. ORCID: https://orcid.org/0000-0002-5618-246X, Gürgen, D. ORCID: https://orcid.org/0000-0001-9241-6537, Bei, Y. ORCID: https://orcid.org/0000-0002-2104-8025, Brückner, L. ORCID: https://orcid.org/0000-0002-6155-2277, Röefzaad, C. ORCID: https://orcid.org/0000-0003-2299-6673, von Stebut, J. ORCID: https://orcid.org/0000-0001-9811-445X, Bardinet, V. ORCID: https://orcid.org/0000-0002-9583-7043, Chamorro Gonzalez, R. ORCID: https://orcid.org/0000-0002-5653-7259, Eggert, A. ORCID: https://orcid.org/0000-0003-3476-8184, Schulte, J.H. ORCID: https://orcid.org/0000-0003-0671-1201, Hundsdörfer, P. ORCID: https://orcid.org/0009-0007-1158-5170, Seifert, G. ORCID: https://orcid.org/0000-0002-7109-9277, Haase, K. ORCID: https://orcid.org/0000-0002-0944-5618, Schäfer, B.W. ORCID: https://orcid.org/0000-0001-5988-2915, Wachtel, M. ORCID: https://orcid.org/0000-0002-6077-3692, Kühl, A.A. ORCID: https://orcid.org/0000-0003-2293-5387, Ortiz, M.V. ORCID: https://orcid.org/0000-0001-9379-314X, Wengner, A.M. ORCID: https://orcid.org/0009-0009-5772-1945, Scheer, M. ORCID: https://orcid.org/0000-0002-0665-6268 and Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X
Molecular Cancer Therapeutics 23 (4): 507-519. 2 April 2024

Genetic determinants of micronucleus formation in vivo.
Adams, D.J., Barlas, B., McIntyre, R.E., Salguero, I., van der Weyden, L., Barros, A., Vicente, J.R., Karimpour, N., Haider, A., Ranzani, M., Turner, G., Thompson, N.A., Harle, V., Olvera-León, R., Robles-Espinoza, C.D., Speak, A.O., Geisler, N., Weninger, W.J., Geyer, S.H., Hewinson, J., Karp, N.A., Fu, B., Yang, F., Kozik, Z., Choudhary, J., Yu, L., van Ruiten, M.S., Rowland, B.D., Lelliott, C.J., Del Castillo Velasco-Herrera, M., Verstraten, R., Bruckner, L., Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X, Rooimans, M.A., de Lange, J., Mohun, T.J., Arends, M.J., Kentistou, K.A., Coelho, P.A., Zhao, Y., Zecchini, H., Perry, J.R.B., Jackson, S.P. and Balmus, G.
Nature 627 (8002): 130-136. 7 March 2024

Passenger gene coamplifications create collateral therapeutic vulnerabilities in cancer.
Bei, Y. ORCID: https://orcid.org/0000-0002-2104-8025, Brame, Luca ORCID: https://orcid.org/0000-0001-5316-2992, Kirchner, M. ORCID: https://orcid.org/0000-0002-7049-534X, Fritsche-Guenther, R. ORCID: https://orcid.org/0000-0002-6965-0226, Kunz, S. ORCID: https://orcid.org/0000-0002-0131-3506, Bhattacharya, A. ORCID: https://orcid.org/0000-0003-3733-7670, Rusu, M.C. ORCID: https://orcid.org/0000-0002-8369-3580, Gürgen, D. ORCID: https://orcid.org/0000-0001-9241-6537, Dubois, F.P.B. ORCID: https://orcid.org/0000-0002-7654-6208, Köppke, J.K.C. ORCID: https://orcid.org/0000-0002-1293-7250, Proba, J. ORCID: https://orcid.org/0009-0006-8293-1248, Wittstruck, N. ORCID: https://orcid.org/0009-0000-4378-3226, Sidorova, O.A. ORCID: https://orcid.org/0009-0004-1459-1662, Chamorro González, R. ORCID: https://orcid.org/0000-0002-5653-7259, Dorado Garcia, H. ORCID: https://orcid.org/0000-0002-2578-3350, Brückner, L. ORCID: https://orcid.org/0000-0002-6155-2277, Xu, R. ORCID: https://orcid.org/0000-0002-5618-246X, Giurgiu, M. ORCID: https://orcid.org/0000-0001-5007-7442, Rodriguez-Fos, E. ORCID: https://orcid.org/0000-0002-2555-0178, Yu, Q. ORCID: https://orcid.org/0000-0002-2151-9624, Spanjaard, B. ORCID: https://orcid.org/0000-0003-1309-8839, Koche, R.P. ORCID: https://orcid.org/0000-0002-6820-5083, Schmitt, C.A. ORCID: https://orcid.org/0000-0002-4731-2226, Schulte, J.H. ORCID: https://orcid.org/0000-0003-0671-1201, Eggert, A. ORCID: https://orcid.org/0000-0003-3476-8184, Haase, K. ORCID: https://orcid.org/0000-0002-0944-5618, Kirwan, J. ORCID: https://orcid.org/0000-0002-5423-1651, Hagemann, A.I. ORCID: https://orcid.org/0000-0001-5491-4607, Mertins, P. ORCID: https://orcid.org/0000-0002-2245-528X, Dörr, J.R. ORCID: https://orcid.org/0000-0002-4927-6548 and Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X
Cancer Discovery 14 (3): 492-507. 1 March 2024

2023

Refphase: Multi-sample phasing reveals haplotype-specific copy number heterogeneity.
Watkins, T.B.K. ORCID: https://orcid.org/0000-0001-7414-737X, Colliver, E.C., Huska, M.R. ORCID: https://orcid.org/0000-0002-0912-745X, Kaufmann, T.L. ORCID: https://orcid.org/0000-0003-4374-1338, Lim, E.L., Duncan, C.B. ORCID: https://orcid.org/0000-0003-3127-228X, Haase, K. ORCID: https://orcid.org/0000-0002-0944-5618, Van Loo, P., Swanton, C., McGranahan, N. and Schwarz, R.F. ORCID: https://orcid.org/0000-0001-9155-4268
PLoS Computational Biology 19 (10): e1011379. 23 October 2023

Cancer origin tracing and timing in two high-risk prostate cancers using multisample whole genome analysis: prospects for personalized medicine.
Nurminen, A., Jaatinen, S., Taavitsainen, S., Högnäs, G., Lesluyes, T., Ansari-Pour, N., Tolonen, T., Haase, K. ORCID: https://orcid.org/0000-0002-0944-5618, Koskenalho, A., Kankainen, M., Jasu, J., Rauhala, H., Kesäniemi, J., Nikupaavola, T., Kujala, P., Rinta-Kiikka, I., Riikonen, J., Kaipia, A., Murtola, T., Tammela, T.L., Visakorpi, T., Nykter, M., Wedge, D.C., Van Loo, P. and Bova, G.S. ORCID: https://orcid.org/0000-0003-1639-3104
Genome Medicine 15 (1): 82. 12 October 2023

Mutational topography reflects clinical neuroblastoma heterogeneity.
Rodriguez-Fos, E. ORCID: https://orcid.org/0000-0002-2555-0178, Planas-Fèlix, M., Burkert, M. ORCID: https://orcid.org/0000-0002-6721-9985, Puiggròs, M., Toedling, J. ORCID: https://orcid.org/0000-0003-1471-1295, Thiessen, N., Blanc, E. ORCID: https://orcid.org/0000-0002-4369-0254, Szymansky, A. ORCID: https://orcid.org/0000-0003-4797-4526, Hertwig, F. ORCID: https://orcid.org/0000-0003-4784-6516, Ishaque, N. ORCID: https://orcid.org/0000-0002-8426-901X, Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Torrents, D., Eggert, A., Koche, R.P., Schwarz, R.F. ORCID: https://orcid.org/0000-0001-9155-4268, Haase, K. ORCID: https://orcid.org/0000-0002-0944-5618, Schulte, J.H. ORCID: https://orcid.org/0000-0003-0671-1201 and Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X
Cell Genomics 3 (10): 100402. 11 October 2023

Paediatric Strategy Forum for medicinal product development of DNA damage response pathway inhibitors in children and adolescents with cancer: ACCELERATE in collaboration with the European Medicines Agency with participation of the Food and Drug Administration.
Pearson, A.D.J., Federico, S. ORCID: https://orcid.org/0000-0002-5807-4876, Gatz, S.A., Ortiz, M., Lesa, G., Scobie, N. ORCID: https://orcid.org/0000-0002-6539-2741, Gounaris, I. ORCID: https://orcid.org/0000-0003-2755-6597, Weiner, S.L., Weigel, B., Unger, T.J., Stewart, E., Smith, M., Slotkin, E.K., Reaman, G., Pappo, A. ORCID: https://orcid.org/0000-0002-5338-3979, Nysom, K. ORCID: https://orcid.org/0000-0003-2935-0058, Norga, K., McDonough, J., Marshall, L.V., Ludwinski, D. ORCID: https://orcid.org/0000-0003-4717-7690, Ligas, F., Karres, D., Kool, M., Horner, T.J., Henssen, A. ORCID: https://orcid.org/0000-0003-1534-778X, Heenen, D. ORCID: https://orcid.org/0000-0002-7703-9902, Hawkins, D.S., Gore, L., Bender, J.G., Galluzzo, S., Fox, E., de Rojas, T., Davies, B.R., Chakrabarti, J., Carmichael, J., Bradford, D., Blanc, P. ORCID: https://orcid.org/0000-0002-7318-8986, Bernardi, R., Benchetrit, S., Akindele, K. and Vassal, G.
European Journal of Cancer 190 : 112950. September 2023

Doxorubicin changes the spatial organization of the genome around active promoters.
Stefanova, M.E. ORCID: https://orcid.org/0000-0002-4419-2839, Ing-Simmons, E. ORCID: https://orcid.org/0000-0002-0394-2429, Stefanov, S. ORCID: https://orcid.org/0000-0003-4341-8725, Flyamer, I., Dorado Garcia, H. ORCID: https://orcid.org/0000-0002-2578-3350, Schöpflin, R., Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X, Vaquerizas, J.M. and Mundlos, S.
Cells 12 (15): 2001. 4 August 2023

Defining the landscape of circular RNAs in neuroblastoma unveils a global suppressive function of MYCN.
Fuchs, S. ORCID: https://orcid.org/0000-0001-9619-4329, Danßmann, C., Klironomos, F., Winkler, A., Fallmann, J. ORCID: https://orcid.org/0000-0002-4573-9939, Kruetzfeldt, L.M. ORCID: https://orcid.org/0000-0003-3630-3727, Szymansky, A. ORCID: https://orcid.org/0000-0003-4797-4526, Naderi, J., Bernhart, S.H. ORCID: https://orcid.org/0000-0002-5928-9449, Grunewald, L., Helmsauer, K. ORCID: https://orcid.org/0000-0003-0773-4114, Rodriguez-Fos, E. ORCID: https://orcid.org/0000-0002-2555-0178, Kirchner, M. ORCID: https://orcid.org/0000-0002-7049-534X, Mertins, P. ORCID: https://orcid.org/0000-0002-2245-528X, Astrahantseff, K. ORCID: https://orcid.org/0000-0002-7872-1997, Suenkel, C. ORCID: https://orcid.org/0000-0002-5326-6043, Toedling, J. ORCID: https://orcid.org/0000-0003-1471-1295, Meggetto, F. ORCID: https://orcid.org/0000-0002-2610-0144, Remke, M. ORCID: https://orcid.org/0000-0002-9404-9993, Stadler, P.F., Hundsdoerfer, P., Deubzer, H.E. ORCID: https://orcid.org/0000-0002-6115-4893, Künkele, A. ORCID: https://orcid.org/0000-0002-8406-5412, Lang, P. ORCID: https://orcid.org/0000-0001-7737-2142, Fuchs, J., Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X, Eggert, A. ORCID: https://orcid.org/0000-0003-3476-8184, Rajewsky, N. ORCID: https://orcid.org/0000-0002-4785-4332, Hertwig, F. ORCID: https://orcid.org/0000-0003-4784-6516 and Schulte, J.H. ORCID: https://orcid.org/0000-0003-0671-1201
Nature Communications 14 (1): 3936. 4 July 2023

CRISPR/Cas9 screen in gastric cancer patient-derived organoids reveals KDM1A-NDRG1 axis as a targetable vulnerability.
Mircetic, J. ORCID: https://orcid.org/0000-0002-9481-240X, Camgöz, A., Abohawya, M., Ding, L., Dietzel, J., Tobar, S.G., Paszkowski-Rogacz, M., Seidlitz, T., Schmäche, T., Mehnert, M.C., Sidorova, O. ORCID: https://orcid.org/0009-0004-1459-1662, Weitz, J., Buchholz, F. ORCID: https://orcid.org/0000-0002-4577-3344 and Stange, D.E.
Small Methods 7 (6): e2201605. 20 June 2023

scEC(&)T-seq: a method for parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single human cells.
Chamorro González, Rocío ORCID: https://orcid.org/0000-0002-5653-7259, Conrad, Thomas ORCID: https://orcid.org/0000-0001-5618-6295, Kasack, Katharina and Henssen, Anton G. ORCID: https://orcid.org/0000-0003-1534-778X
Research Square. 23 May 2023

Disentangling extrachromosomal circular DNA heterogeneity in single cells with scEC&T-seq.
Chamorro González, R. ORCID: https://orcid.org/0000-0002-5653-7259 and Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X
Nature Genetics 55 (5): 740-741. May 2023

Parallel in-depth analysis of repeat expansions in ataxia patients by long-read sequencing.
Erdmann, H., Schöberl, F., Giurgiu, M. ORCID: https://orcid.org/0000-0001-5007-7442, Leal Silva, R.M., Scholz, V., Scharf, F., Wendlandt, M., Kleinle, S., Deschauer, M., Nübling, G., Heide, W., Babacan, S.S., Schneider, C., Neuhann, T., Hahn, K., Schoser, B., Holinski-Feder, E., Wolf, D.A. and Abicht, A. ORCID: https://orcid.org/0000-0002-2757-8131
Brain 146 (5): 1831-1843. May 2023

Parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells.
Chamorro González, R. ORCID: https://orcid.org/0000-0002-5653-7259, Conrad, T. ORCID: https://orcid.org/0000-0001-5618-6295, Stöber, M.C. ORCID: https://orcid.org/0000-0002-6679-5577, Xu, R. ORCID: https://orcid.org/0000-0002-5618-246X, Giurgiu, M. ORCID: https://orcid.org/0000-0001-5007-7442, Rodriguez-Fos, E. ORCID: https://orcid.org/0000-0002-2555-0178, Kasack, K., Brückner, L. ORCID: https://orcid.org/0000-0002-6155-2277, van Leen, E. ORCID: https://orcid.org/0000-0001-9545-4803, Helmsauer, K. ORCID: https://orcid.org/0000-0003-0773-4114, Dorado Garcia, H. ORCID: https://orcid.org/0000-0002-2578-3350, Stefanova, M.E. ORCID: https://orcid.org/0000-0002-4419-2839, Hung, K.L. ORCID: https://orcid.org/0000-0002-3662-4662, Bei, Y. ORCID: https://orcid.org/0000-0002-2104-8025, Schmelz, K., Lodrini, M., Mundlos, S., Chang, H.Y. ORCID: https://orcid.org/0000-0002-9459-4393, Deubzer, H.E. ORCID: https://orcid.org/0000-0002-6115-4893, Sauer, S. ORCID: https://orcid.org/0000-0002-4794-3693, Eggert, A. ORCID: https://orcid.org/0000-0003-3476-8184, Schulte, J.H. ORCID: https://orcid.org/0000-0003-0671-1201, Schwarz, R.F. ORCID: https://orcid.org/0000-0001-9155-4268, Haase, K. ORCID: https://orcid.org/0000-0002-0944-5618, Koche, R.P. ORCID: https://orcid.org/0000-0002-6820-5083 and Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X
Nature Genetics 55 (5): 880-890. May 2023

Pre-operative radiotherapy is associated with superior local relapse-free survival in advanced synovial sarcoma.
Scheer, M. ORCID: https://orcid.org/0000-0002-0665-6268, Hallmen, E., Vokuhl, C., Fuchs, J., Tunn, P.U., Münter, M., Timmermann, B., Bauer, S., Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X, Kazanowska, B., Niggli, F., Ladenstein, R., Ljungman, G., Eggert, A., Klingebiel, T. and Koscielniak, E.
Journal of Cancer Research and Clinical Oncology 149 (5): 1717-1731. May 2023

Mutational topography reflects clinical neuroblastoma heterogeneity.
Rodriguez-Fos, Elias ORCID: https://orcid.org/0000-0002-2555-0178, Planas-Fèlix, Mercè, Burkert, Martin ORCID: https://orcid.org/0000-0002-6721-9985, Puiggròs, Montserrat, Toedling, Joern, Thiessen, Nina, Blanc, Eric ORCID: https://orcid.org/0000-0002-4369-0254, Szymansky, Annabell ORCID: https://orcid.org/0000-0003-4797-4526, Hertwig, Falk ORCID: https://orcid.org/0000-0003-4784-6516, Ishaque, Naveed ORCID: https://orcid.org/0000-0002-8426-901X, Beule, Dieter ORCID: https://orcid.org/0000-0002-3284-0632, Torrents, David, Eggert, Angelika, Koche, Richard P., Schwarz, Roland F. ORCID: https://orcid.org/0000-0001-9155-4268, Haase, Kerstin ORCID: https://orcid.org/0000-0002-0944-5618, Schulte, Johannes H. ORCID: https://orcid.org/0000-0003-0671-1201 and Henssen, Anton G. ORCID: https://orcid.org/0000-0003-1534-778X
[Dataset] 27 April 2023

Long-read sequencing of diagnosis and post-therapy medulloblastoma reveals complex rearrangement patterns and epigenetic signatures.
Rausch, T., Snajder, R., Leger, A., Simovic, M., Giurgiu, M. ORCID: https://orcid.org/0000-0001-5007-7442, Villacorta, L., Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X, Fröhling, S., Stegle, O., Birney, E., Bonder, M.J. ORCID: https://orcid.org/0000-0002-8431-3180, Ernst, A. and Korbel, J.O.
Cell Genomics 3 (4): 100281. 12 April 2023

Single-cell profiling of alveolar rhabdomyosarcoma reveals RAS pathway inhibitors as cell-fate hijackers with therapeutic relevance.
Danielli, S.G. ORCID: https://orcid.org/0000-0003-3101-3114, Porpiglia, E. ORCID: https://orcid.org/0000-0003-2652-899X, De Micheli, A.J. ORCID: https://orcid.org/0000-0002-9985-2638, Navarro, N. ORCID: https://orcid.org/0000-0002-2160-6656, Zellinger, M.J., Bechtold, I., Kisele, S. ORCID: https://orcid.org/0000-0003-0369-7854, Volken, L., Marques, J.G. ORCID: https://orcid.org/0000-0001-7152-9655, Kasper, S. ORCID: https://orcid.org/0000-0003-2698-0206, Bode, P.K. ORCID: https://orcid.org/0000-0002-9633-4042, Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X, Gürgen, D. ORCID: https://orcid.org/0000-0001-9241-6537, Delattre, O., Surdez, D. ORCID: https://orcid.org/0000-0002-7118-7859, Roma, J. ORCID: https://orcid.org/0000-0001-7692-6123, Bühlmann, P. ORCID: https://orcid.org/0000-0002-1782-6015, Blau, H.M. ORCID: https://orcid.org/0000-0001-6503-5480, Wachtel, M. and Schäfer, B.W. ORCID: https://orcid.org/0000-0001-5988-2915
Science Advances 9 (6): eade9238. 10 February 2023

CORUM: the comprehensive resource of mammalian protein complexes-2022.
Tsitsiridis, G., Steinkamp, R., Giurgiu, M. ORCID: https://orcid.org/0000-0001-5007-7442, Brauner, B., Fobo, G., Frishman, G., Montrone, C. and Ruepp, A. ORCID: https://orcid.org/0000-0003-1705-3515
Nucleic Acids Research 51 (D1): D539-D545. 6 January 2023

Rituximab therapy after pediatric hematopoietic stem cell transplantation can cause prolonged B cell impairment and increases the risk for infections - a retrospective matched cohort study.
Launspach, M., Temel, D., Ohlendorf, E., Zirngibl, F., Materne, B., Oevermann, L., Deubzer, H.E. ORCID: https://orcid.org/0000-0002-6115-4893, Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X, Künkele, A., Hundsdörfer, P., von Bernuth, H., Pruß, A., Eggert, A., von Stackelberg, A., Lang, P. and Schulte, J.H. ORCID: https://orcid.org/0000-0003-0671-1201
Haematologica 108 (1): 267-272. January 2023

2022

Extrachromosomal DNA (ecDNA): an origin of tumor heterogeneity, genomic remodeling, and drug resistance.
Pecorino, L.T., Verhaak, R.G.W., Henssen, A. ORCID: https://orcid.org/0000-0003-1534-778X and Mischel, P.S. ORCID: https://orcid.org/0000-0002-4560-2211
Biochemical Society Transactions 50 (6): 1911-1920. December 2022

Extrachromosomal DNA amplifications in cancer.
Yi, E. ORCID: https://orcid.org/0000-0002-7839-7795, Chamorro González, R. ORCID: https://orcid.org/0000-0002-5653-7259, Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X and Verhaak, R.G.W. ORCID: https://orcid.org/0000-0003-2773-0436
Nature Reviews Genetics 23 (12): 760-771. December 2022

Targeted profiling of human extrachromosomal DNA by CRISPR-CATCH.
Hung, K.L. ORCID: https://orcid.org/0000-0002-3662-4662, Luebeck, J. ORCID: https://orcid.org/0000-0003-4391-979X, Dehkordi, S.R., Colón, C.I., Li, R. ORCID: https://orcid.org/0000-0002-3085-5267, Wong, I.T.L., Coruh, C., Dharanipragada, P., Lomeli, S.H., Weiser, N.E. ORCID: https://orcid.org/0000-0001-9971-2961, Moriceau, G., Zhang, X. ORCID: https://orcid.org/0000-0003-1706-2868, Bailey, C., Houlahan, K.E., Yang, W., González, R.C. ORCID: https://orcid.org/0000-0002-5653-7259, Swanton, C. ORCID: https://orcid.org/0000-0002-4299-3018, Curtis, C., Jamal-Hanjani, M. ORCID: https://orcid.org/0000-0003-1212-1259, Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X, Law, J.A. ORCID: https://orcid.org/0000-0001-7472-7753, Greenleaf, W.J. ORCID: https://orcid.org/0000-0003-1409-3095, Lo, R.S. ORCID: https://orcid.org/0000-0002-5337-5004, Mischel, P.S. ORCID: https://orcid.org/0000-0002-4560-2211, Bafna, V. ORCID: https://orcid.org/0000-0002-5810-6241 and Chang, H.Y. ORCID: https://orcid.org/0000-0002-9459-4393
Nature Genetics 54 (11): 1746–1754. November 2022

The evolutionary dynamics of extrachromosomal DNA in human cancers.
Lange, J.T. ORCID: https://orcid.org/0000-0002-4246-6058, Rose, J.C. ORCID: https://orcid.org/0000-0003-1810-4337, Chen, C.Y. ORCID: https://orcid.org/0000-0002-1579-024X, Pichugin, Y., Xie, L., Tang, J., Hung, K.L. ORCID: https://orcid.org/0000-0002-3662-4662, Yost, K.E., Shi, Q., Erb, M.L., Rajkumar, U., Wu, S. ORCID: https://orcid.org/0000-0001-8329-7492, Taschner-Mandl, S. ORCID: https://orcid.org/0000-0002-1439-5301, Bernkopf, M. ORCID: https://orcid.org/0000-0001-6650-4592, Swanton, C. ORCID: https://orcid.org/0000-0002-4299-3018, Liu, Z. ORCID: https://orcid.org/0000-0002-3592-3150, Huang, W. ORCID: https://orcid.org/0000-0002-9016-2665, Chang, H.Y. ORCID: https://orcid.org/0000-0002-9459-4393, Bafna, V. ORCID: https://orcid.org/0000-0002-5810-6241, Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X, Werner, B. ORCID: https://orcid.org/0000-0002-6857-8699 and Mischel, P.S. ORCID: https://orcid.org/0000-0002-4560-2211
Nature Genetics 54 (10): 1527-1533. October 2022

Therapeutic targeting of ATR in alveolar rhabdomyosarcoma.
Dorado Garcia, H. ORCID: https://orcid.org/0000-0002-2578-3350, Pusch, F. ORCID: https://orcid.org/0000-0002-7152-080X, Bei, Y. ORCID: https://orcid.org/0000-0002-2104-8025, von Stebut, J. ORCID: https://orcid.org/0000-0001-9811-445X, Ibáñez, G., Guillan, K., Imami, K. ORCID: https://orcid.org/0000-0002-7451-4982, Gürgen, D. ORCID: https://orcid.org/0000-0001-9241-6537, Rolff, J., Helmsauer, K. ORCID: https://orcid.org/0000-0003-0773-4114, Meyer-Liesener, S., Timme, N., Bardinet, V. ORCID: https://orcid.org/0000-0002-9583-7043, Chamorro González, R. ORCID: https://orcid.org/0000-0002-5653-7259, MacArthur, I.C. ORCID: https://orcid.org/0000-0003-1718-1349, Chen, C.Y. ORCID: https://orcid.org/0000-0002-1579-024X, Schulz, J., Wengner, A.M. ORCID: https://orcid.org/0009-0009-5772-1945, Furth, C., Lala, B., Eggert, A. ORCID: https://orcid.org/0000-0003-3476-8184, Seifert, G., Hundsoerfer, P., Kirchner, M. ORCID: https://orcid.org/0000-0002-7049-534X, Mertins, P. ORCID: https://orcid.org/0000-0002-2245-528X, Selbach, M. ORCID: https://orcid.org/0000-0003-2454-8751, Lissat, A., Dubois, F. ORCID: https://orcid.org/0000-0002-7654-6208, Horst, D., Schulte, J.H. ORCID: https://orcid.org/0000-0003-0671-1201, Spuler, S. ORCID: https://orcid.org/0000-0002-0155-1117, You, D., Dela Cruz, F., Kung, A.L. ORCID: https://orcid.org/0000-0002-9091-488X, Haase, K. ORCID: https://orcid.org/0000-0002-0944-5618, Di Virgilio, M. ORCID: https://orcid.org/0000-0001-5189-0793, Scheer, M., Ortiz, M.V. and Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X
Nature Communications 13 (1): 4297. 25 July 2022

Target actionability review to evaluate CDK4/6 as a therapeutic target in paediatric solid and brain tumours.
Schubert, N.A., Chen, C.Y., Rodríguez, A., Koster, J., Dowless, M., Pfister, S.M., Shields, D.J., Stancato, L.F., Vassal, G., Caron, H.N., van den Boogaard, M.L., Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X and Molenaar, J.J.
European Journal of Cancer 170 : 196-208. July 2022

Mutations in ALK signaling pathways conferring resistance to ALK inhibitor treatment lead to collateral vulnerabilities in neuroblastoma cells.
Berlak, M. ORCID: https://orcid.org/0000-0003-4437-3477, Tucker, E., Dorel, M. ORCID: https://orcid.org/0000-0002-1663-2075, Winkler, A., McGearey, A., Rodriguez-Fos, E. ORCID: https://orcid.org/0000-0002-2555-0178, da Costa, B.M., Barker, K., Fyle, E., Calton, E., Eising, S., Ober, K., Hughes, D., Koutroumanidou, E., Carter, P., Stankunaite, R., Proszek, P., Jain, N., Rosswog, C., Dorado-Garcia, H. ORCID: https://orcid.org/0000-0002-2578-3350, Molenaar, J.J., Hubank, M., Barone, G., Anderson, J., Lang, P., Deubzer, H.E. ORCID: https://orcid.org/0000-0002-6115-4893, Künkele, A., Fischer, M., Eggert, A., Kloft, C., Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X, Boettcher, M., Hertwig, F. ORCID: https://orcid.org/0000-0003-4784-6516, Blüthgen, N. ORCID: https://orcid.org/0000-0002-0171-7447, Chesler, L. and Schulte, J.H. ORCID: https://orcid.org/0000-0003-0671-1201
Molecular Cancer 21 (1): 126. 10 June 2022

Detection and validation of circular DNA fragments using nanopore sequencing.
Tüns, A.I., Hartmann, T., Magin, S., Chamorro González, R. ORCID: https://orcid.org/0000-0002-5653-7259, Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X, Rahmann, S., Schramm, A. and Köster, J.
Frontiers in Genetics 13 : 867018. 30 May 2022

Genomic evolution and personalized therapy of an infantile fibrosarcoma harboring an NTRK oncogenic fusion.
Thorwarth, A., Haase, K. ORCID: https://orcid.org/0000-0002-0944-5618, Röefzaad, C. ORCID: https://orcid.org/0000-0003-2299-6673, Pajtler, K.W. ORCID: https://orcid.org/0000-0002-3562-6121, Schramm, K., Hauptmann, K., Behnke, A. ORCID: https://orcid.org/0000-0003-0629-9587, Vokuhl, C., Elgeti, T. ORCID: https://orcid.org/0000-0002-7155-6044, Gratopp, A., Schulte, J.H. ORCID: https://orcid.org/0000-0003-0671-1201, Scheer, M., Hernáiz Driever, P., Nysom, K. ORCID: https://orcid.org/0000-0003-2935-0058, Eggert, A. ORCID: https://orcid.org/0000-0003-3476-8184, Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X and Deubzer, H.E. ORCID: https://orcid.org/0000-0002-6115-4893
JCO Precision Oncology 6 : e2100283. 25 May 2022

Shedding light on ecDNA behavior using CRISPR-based live-cell imaging.
Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X
Cancer Discovery 12 (2): 293-295. 9 February 2022

The genomic and spatial mobility of extrachromosomal DNA and its implications for cancer therapy.
van Leen, E. ORCID: https://orcid.org/0000-0001-9545-4803, Brückner, L. ORCID: https://orcid.org/0000-0002-6155-2277 and Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X
Nature Genetics 54 (2): 107-114. February 2022

2021

ecDNA hubs drive cooperative intermolecular oncogene expression.
Hung, K.L., Yost, K.E., Xie, L., Shi, Q., Helmsauer, K., Luebeck, J., Schöpflin, R., Lange, J.T., Chamorro González, R., Weiser, N.E., Chen, C., Valieva, M.E., Wong, I.T.L., Wu, S., Dehkordi, S.R., Duffy, C.V., Kraft, K., Tang, J., Belk, J.A., Rose, J.C., Corces, M.R., Granja, J.M., Li, R. ORCID: https://orcid.org/0000-0002-3085-5267, Rajkumar, U., Friedlein, J., Bagchi, A., Satpathy, A.T., Tjian, R., Mundlos, S., Bafna, V., Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X, Mischel, P.S., Liu, Z. and Chang, H.Y.
Nature 600 (7890): 731-736. 23 December 2021

The effect of adjuvant therapies on long-term outcome for primary resected synovial sarcoma in a series of mainly children and adolescents.
Scheer, M. ORCID: https://orcid.org/0000-0002-0665-6268, Vokuhl, C., Bauer, S., Fuchs, J., Loff, S., Timmermann, B., Münter, M., Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X, Kazanowska, B., Niggli, F., Ladenstein, R., Ljungman, G., Koscielniak, E. and Klingebiel, T.
Journal of Cancer Research and Clinical Oncology 147 (12): 3735-3747. December 2021

Spatial and temporal intratumour heterogeneity has potential consequences for single biopsy-based neuroblastoma treatment decisions.
Schmelz, K., Toedling, J. ORCID: https://orcid.org/0000-0003-1471-1295, Huska, M. ORCID: https://orcid.org/0000-0002-0912-745X, Cwikla, M.C. ORCID: https://orcid.org/0000-0002-6679-5577, Kruetzfeldt, L.M. ORCID: https://orcid.org/0000-0003-3630-3727, Proba, J., Ambros, P.F., Ambros, I.M., Boral, S., Lodrini, M., Chen, C.Y. ORCID: https://orcid.org/0000-0002-1579-024X, Burkert, M. ORCID: https://orcid.org/0000-0002-6721-9985, Guergen, D. ORCID: https://orcid.org/0000-0001-9241-6537, Szymansky, A. ORCID: https://orcid.org/0000-0003-4797-4526, Astrahantseff, K. ORCID: https://orcid.org/0000-0002-7872-1997, Kuenkele, A., Haase, K. ORCID: https://orcid.org/0000-0002-0944-5618, Fischer, M. ORCID: https://orcid.org/0000-0003-1363-1242, Deubzer, H.E. ORCID: https://orcid.org/0000-0002-6115-4893, Hertwig, F. ORCID: https://orcid.org/0000-0003-4784-6516, Hundsdoerfer, P., Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X, Schwarz, R.F. ORCID: https://orcid.org/0000-0001-9155-4268, Schulte, J.H. ORCID: https://orcid.org/0000-0003-0671-1201 and Eggert, A. ORCID: https://orcid.org/0000-0003-3476-8184
Nature Communications 12 (1): 6804. 23 November 2021

Inhibiting lysine demethylase 1A improves L1CAM-specific CAR T cell therapy by unleashing antigen-independent killing via the FAS-FASL axis.
Sulejmani, O. ORCID: https://orcid.org/0000-0003-1600-317X, Grunewald, L., Andersch, L., Schwiebert, S., Klaus, A., Winkler, A., Astrahantseff, K., Eggert, A. ORCID: https://orcid.org/0000-0003-3476-8184, Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X, Schulte, J.H. ORCID: https://orcid.org/0000-0003-0671-1201, Anders, K. ORCID: https://orcid.org/0000-0002-0429-200X and Künkele, A. ORCID: https://orcid.org/0000-0002-8406-5412
Cancers 13 (21): 5489. 31 October 2021

Class I histone deacetylases (HDAC) critically contribute to Ewing sarcoma pathogenesis.
Schmidt, O., Nehls, N., Prexler, C., von Heyking, K., Groll, T., Pardon, K., Garcia, H.D. ORCID: https://orcid.org/0000-0002-2578-3350, Hensel, T., Gürgen, D. ORCID: https://orcid.org/0000-0001-9241-6537, Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X, Eggert, A., Steiger, K., Burdach, S. and Richter, G.H.S. ORCID: https://orcid.org/0000-0003-4782-5539
Journal of Experimental & Clinical Cancer Research 40 (1): 322. 15 October 2021

Subclone eradication analysis identifies targets for enhanced cancer therapy and reveals L1 retrotransposition as a dynamic source of cancer heterogeneity.
Ketola, K., Kaljunen, H., Taavitsainen, S., Kaarijärvi, R., Järvelä, E. ORCID: https://orcid.org/0000-0002-5249-2508, Rodriguez Martin, B., Haase, K. ORCID: https://orcid.org/0000-0002-0944-5618, Woodcock, D.J., Tubio, J., Wedge, D.C. ORCID: https://orcid.org/0000-0002-7572-3196, Nykter, M. and Bova, G.S. ORCID: https://orcid.org/0000-0003-1639-3104
Cancer Research 81 (19): 4901-4909. October 2021

Negative correlation of single-cell PAX3:FOXO1 expression with tumorigenicity in rhabdomyosarcoma.
Regina, C., Hamed, E. ORCID: https://orcid.org/0000-0002-3595-677X, Andrieux, G., Angenendt, S. ORCID: https://orcid.org/0000-0003-0827-7613, Schneider, M., Ku, M. ORCID: https://orcid.org/0000-0001-5168-4308, Follo, M. ORCID: https://orcid.org/0000-0002-3090-7442, Wachtel, M., Ke, E., Kikuchi, K. ORCID: https://orcid.org/0000-0003-3097-7480, Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X, Schäfer, B.W., Boerries, M. ORCID: https://orcid.org/0000-0002-3670-0602, Wagers, A.J. ORCID: https://orcid.org/0000-0002-0066-0485, Keller, C. ORCID: https://orcid.org/0000-0003-2505-7487 and Hettmer, S. ORCID: https://orcid.org/0000-0003-1709-4448
Life Science Alliance 4 (9): e202001002. September 2021

Neuroblastoma risk assessment and treatment stratification with hybrid capture-based panel sequencing.
Szymansky, A. ORCID: https://orcid.org/0000-0003-4797-4526, Kruetzfeldt, L.M. ORCID: https://orcid.org/0000-0003-3630-3727, Heukamp, L.C., Hertwig, F. ORCID: https://orcid.org/0000-0003-4784-6516, Theissen, J., Deubzer, H.E. ORCID: https://orcid.org/0000-0002-6115-4893, Willing, E.M., Menon, R., Fuchs, S. ORCID: https://orcid.org/0000-0001-9619-4329, Thole, T., Schulte, S., Schmelz, K., Künkele, A. ORCID: https://orcid.org/0000-0002-8406-5412, Lang, P., Fuchs, J., Eggert, A., Eckert, C., Fischer, M., Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X, Rodriguez-Fos, E. ORCID: https://orcid.org/0000-0002-2555-0178 and Schulte, J.H. ORCID: https://orcid.org/0000-0003-0671-1201
Journal of Personalized Medicine 11 (8): 691. August 2021

A reproducible bioprinted 3D tumor model serves as a preselection tool for CAR T cell therapy optimization.
Grunewald, L., Lam, T., Andersch, L., Klaus, A., Schwiebert, S., Winkler, A., Gauert, A., Heeren-Hagemann, A.I., Astrahantseff, K., Klironomos, F., Thomas, A., Deubzer, H.E. ORCID: https://orcid.org/0000-0002-6115-4893, Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X, Eggert, A., Schulte, J.H. ORCID: https://orcid.org/0000-0003-0671-1201, Anders, K. ORCID: https://orcid.org/0000-0002-0429-200X, Kloke, L. and Künkele, A.
Frontiers in Immunology 12 : 689697. 29 June 2021

CD28 co-stimulus achieves superior CAR T cell effector function against solid tumors than 4-1BB co-stimulus.
Textor, A. ORCID: https://orcid.org/0000-0002-9952-4650, Grunewald, L., Anders, K. ORCID: https://orcid.org/0000-0002-0429-200X, Klaus, A., Schwiebert, S., Winkler, A., Stecklum, M., Rolff, J., Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X, Höpken, U.E. ORCID: https://orcid.org/0000-0002-0776-4893, Eggert, A., Schulte, J.H. ORCID: https://orcid.org/0000-0003-0671-1201, Jensen, M.C., Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321 and Künkele, A. ORCID: https://orcid.org/0000-0002-8406-5412
Cancers 13 (5): 1050. 2 March 2021

Combined inhibition of Aurora-A and ATR kinases results in regression of MYCN-amplified neuroblastoma.
Roeschert, I., Poon, E. ORCID: https://orcid.org/0000-0002-0616-2487, Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X, Dorado Garcia, H. ORCID: https://orcid.org/0000-0002-2578-3350, Gatti, M., Giansanti, C. ORCID: https://orcid.org/0000-0003-3229-8385, Jamin, Y. ORCID: https://orcid.org/0000-0003-0350-3757, Ade, C.P. ORCID: https://orcid.org/0000-0001-7226-1179, Gallant, P., Schülein-Völk, C., Beli, P. ORCID: https://orcid.org/0000-0001-9507-9820, Richards, M. ORCID: https://orcid.org/0000-0003-1108-2825, Rosenfeldt, M., Altmeyer, M. ORCID: https://orcid.org/0000-0003-3780-1170, Anderson, J., Eggert, A., Dobbelstein, M., Bayliss, R. ORCID: https://orcid.org/0000-0003-0604-2773, Chesler, L. ORCID: https://orcid.org/0000-0001-7842-2068, Büchel, G. ORCID: https://orcid.org/0000-0001-7070-7341 and Eilers, M. ORCID: https://orcid.org/0000-0002-0376-6533
Nature Cancer 2 (3): 312-326. March 2021

2020

Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma.
Helmsauer, K. ORCID: https://orcid.org/0000-0003-0773-4114, Valieva, M.E. ORCID: https://orcid.org/0000-0002-4419-2839, Ali, S. ORCID: https://orcid.org/0000-0002-0351-1645, Chamorro Gonzalez, R. ORCID: https://orcid.org/0000-0002-5653-7259, Schöpflin, R., Röefzaad, C. ORCID: https://orcid.org/0000-0003-2299-6673, Bei, Y. ORCID: https://orcid.org/0000-0002-2104-8025, Dorado Garcia, H. ORCID: https://orcid.org/0000-0002-2578-3350, Rodriguez-Fos, E. ORCID: https://orcid.org/0000-0002-2555-0178, Puiggròs, M. ORCID: https://orcid.org/0000-0001-5034-7924, Kasack, K., Haase, K. ORCID: https://orcid.org/0000-0002-0944-5618, Keskeny, C. ORCID: https://orcid.org/0000-0003-3297-7329, Chen, C.Y. ORCID: https://orcid.org/0000-0002-1579-024X, Kuschel, L.P. ORCID: https://orcid.org/0000-0001-7794-2205, Euskirchen, P. ORCID: https://orcid.org/0000-0002-9138-805X, Heinrich, V., Robson, M.I. ORCID: https://orcid.org/0000-0003-1126-3538, Rosswog, C., Toedling, J. ORCID: https://orcid.org/0000-0003-1471-1295, Szymansky, A. ORCID: https://orcid.org/0000-0003-4797-4526, Hertwig, F. ORCID: https://orcid.org/0000-0003-4784-6516, Fischer, M. ORCID: https://orcid.org/0000-0003-1363-1242, Torrents, D., Eggert, A., Schulte, J.H. ORCID: https://orcid.org/0000-0003-0671-1201, Mundlos, S., Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X and Koche, R.P. ORCID: https://orcid.org/0000-0002-6820-5083
Nature Communications 11 (1): 5823. 16 November 2020

Karzinogenese: Big Bang oder kontinuierliche Evolution?
Haase, K. ORCID: https://orcid.org/0000-0002-0944-5618 and Schwarz, R.F. ORCID: https://orcid.org/0000-0001-9155-4268
BIOspektrum 26 (7): 718-720. November 2020

Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancers.
Kim, H. ORCID: https://orcid.org/0000-0003-4244-6126, Nguyen, N.P., Turner, K., Wu, S. ORCID: https://orcid.org/0000-0001-8329-7492, Gujar, A.D. ORCID: https://orcid.org/0000-0003-0689-6680, Luebeck, J. ORCID: https://orcid.org/0000-0003-4391-979X, Liu, J., Deshpande, V., Rajkumar, U., Namburi, S., Amin, S.B., Yi, E. ORCID: https://orcid.org/0000-0002-7839-7795, Menghi, F., Schulte, J.H., Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X, Chang, H.Y. ORCID: https://orcid.org/0000-0002-9459-4393, Beck, C.R. ORCID: https://orcid.org/0000-0001-7821-8489, Mischel, .S. ORCID: https://orcid.org/0000-0002-4560-2211, Bafna, V. ORCID: https://orcid.org/0000-0002-5810-6241 and Verhaak, R.G.W. ORCID: https://orcid.org/0000-0003-2773-0436
Nature Genetics 52 (9): 891-897. September 2020

Central memory phenotype drives success of checkpoint inhibition in combination with CAR T cells.
Toews, K., Grunewald, L., Schwiebert, S., Klaus, A., Winkler, A., Ali, S., Zirngibl, F., Astrahantseff, K., Wagner, D.L., Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X, Deubzer, H.E. ORCID: https://orcid.org/0000-0002-6115-4893, Schulte, J.H., Ochsenreither, S., Eggert, A. and Künkele, A. ORCID: https://orcid.org/0000-0002-8406-5412
Molecular Carcinogenesis 59 (7): 724-273. July 2020

Partner independent fusion gene detection by multiplexed CRISPR-Cas9 enrichment and long read nanopore sequencing.
Stangl, C., de Blank, S. ORCID: https://orcid.org/0000-0003-2191-5675, Renkens, I., Westera, L., Verbeek, T., Valle-Inclan, J.E., Chamorro González, R. ORCID: https://orcid.org/0000-0002-5653-7259, Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X, van Roosmalen, M.J., Stam, R.W., Voest, E.E. ORCID: https://orcid.org/0000-0001-8249-9586, Kloosterman, W.P. ORCID: https://orcid.org/0000-0003-3357-4580, van Haaften, G. ORCID: https://orcid.org/0000-0003-3033-0329 and Monroe, G.R. ORCID: https://orcid.org/0000-0002-8653-2643
Nature Communications 11 (1): 2861. 5 June 2020

What is extrachromosomal circular DNA and what does it do?
Chiu, R.W.K., Dutta, A., Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X, Lo, Y.M.D., Mischel, P. and Regenberg, B.
Clinical Chemistry 66 (6): 754-759. June 2020

Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma.
Marchetto, A. ORCID: https://orcid.org/0000-0002-8873-2251, Ohmura, S. ORCID: https://orcid.org/0000-0002-0930-5172, Orth, M.F. ORCID: https://orcid.org/0000-0002-1789-6427, Knott, M.M.L. ORCID: https://orcid.org/0000-0002-6995-3702, Colombo, M.V. ORCID: https://orcid.org/0000-0002-6018-9920, Arrigoni, C. ORCID: https://orcid.org/0000-0001-6808-1642, Bardinet, V., Saucier, D. ORCID: https://orcid.org/0000-0001-8484-198X, Wehweck, F.S., Li, J., Stein, S., Gerke, J.S., Baldauf, M.C., Musa, J. ORCID: https://orcid.org/0000-0002-9138-1819, Dallmayer, M., Romero-Pérez, L. ORCID: https://orcid.org/0000-0003-3196-4382, Hölting, T.L.B. ORCID: https://orcid.org/0000-0001-5598-7330, Amatruda, J.F. ORCID: https://orcid.org/0000-0002-9901-2137, Cossarizza, A. ORCID: https://orcid.org/0000-0002-5381-1558, Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X, Kirchner, T., Moretti, M., Cidre-Aranaz, F. ORCID: https://orcid.org/0000-0002-0246-7179, Sannino, G. and Grünewald, T.G.P. ORCID: https://orcid.org/0000-0003-0920-7377
Nature Communications 11 (1): 2423. 15 May 2020

Synovial sarcoma disease characteristics and primary tumor sites differ between patient age groups: a report of the Cooperative Weichteilsarkom Studiengruppe (CWS).
Scheer, M. ORCID: https://orcid.org/0000-0002-0665-6268, Blank, B., Bauer, S., Vokuhl, C., Stegmaier, S., Feuchtgruber, S., Henssen, A. ORCID: https://orcid.org/0000-0003-1534-778X, Sparber-Sauer, M., Eggert, A., Handgretinger, R., Pekrun, A., Rossig, C., Rutkowski, S., Schlegel, P.G., Schrappe, M., Simon, T., Kazanowska, B., Niggli, F., Ladenstein, R., Ljungman, G., Jahnukainen, K., Fuchs, J., Bielack, S.S., Koscielniak, E. and Klingebiel, T.
Journal of Cancer Research and Clinical Oncology 146 (4): 953-960. April 2020

Tumor-derived extracellular vesicles impair CD171-specific CD4(+) CAR T cell efficacy.
Ali, S., Toews, K., Schwiebert, S., Klaus, A., Winkler, A., Grunewald, L., Oevermann, L., Deubzer, H.E. ORCID: https://orcid.org/0000-0002-6115-4893, Tüns, A., Jensen, M.C., Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X, Eggert, A., Schulte, J.H., Schwich, E., Rebmann, V., Schramm, A. and Künkele, A.
Frontiers in Immunology 11 : 531. 31 March 2020

High specificity of BCL11B and GLG1 for EWSR1-FLI1 and EWSR1-ERG positive Ewing sarcoma.
Orth, M.F. ORCID: https://orcid.org/0000-0002-1789-6427, Hölting, T.L.B., Dallmayer, M., Wehweck, F.S., Paul, T., Musa, J. ORCID: https://orcid.org/0000-0002-9138-1819, Baldauf, M.C., Surdez, D. ORCID: https://orcid.org/0000-0002-7118-7859, Delattre, O., Knott, M.M.L. ORCID: https://orcid.org/0000-0002-6995-3702, Romero-Pérez, L. ORCID: https://orcid.org/0000-0003-3196-4382, Kasan, M. ORCID: https://orcid.org/0000-0002-9031-2109, Cidre-Aranaz, F. ORCID: https://orcid.org/0000-0002-0246-7179, Gerke, J.S., Ohmura, S. ORCID: https://orcid.org/0000-0002-0930-5172, Li, J., Marchetto, A., Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X, Özen, Ö., Sugita, S., Hasegawa, T., Kanaseki, T., Bertram, S., Dirksen, U. ORCID: https://orcid.org/0000-0002-5435-7860, Hartmann, W., Kirchner, T. and Grünewald, T.G.P. ORCID: https://orcid.org/0000-0003-0920-7377
Cancers 12 (3): 644. 10 March 2020

Reflection of neuroblastoma intratumor heterogeneity in the new OHC-NB1 disease model.
Thole, T.M., Toedling, J. ORCID: https://orcid.org/0000-0003-1471-1295, Sprüssel, A. ORCID: https://orcid.org/0000-0001-6079-5907, Pfeil, S., Savelyeva, L., Capper, D., Messerschmidt, C. ORCID: https://orcid.org/0000-0001-8632-656X, Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Groeneveld-Krentz, S., Eckert, C., Gambara, G., Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X, Finkler, S., Schulte, J.H., Sieber, A., Bluethgen, N. ORCID: https://orcid.org/0000-0002-0171-7447, Regenbrecht, C.R.A., Künkele, A., Lodrini, M., Eggert, A. and Deubzer, H.E. ORCID: https://orcid.org/0000-0002-6115-4893
International Journal of Cancer 146 (4): 1031-1041. 15 February 2020

Small-molecule dual PLK1 and BRD4 inhibitors are active against preclinical models of pediatric solid tumors.
Timme, N., Han, Y., Liu, S., Yosief, H.O., García, H.D. ORCID: https://orcid.org/0000-0002-2578-3350, Bei, Y. ORCID: https://orcid.org/0000-0002-2104-8025, Klironomos, F., MacArthur, I.C., Szymansky, A. ORCID: https://orcid.org/0000-0003-4797-4526, von Stebut, J. ORCID: https://orcid.org/0000-0001-9811-445X, Bardinet, V. ORCID: https://orcid.org/0000-0002-9583-7043, Dohna, C., Künkele, A., Rolff, J., Hundsdörfer, P., Lissat, A., Seifert, G., Eggert, A., Schulte, J.H., Zhang, W. and Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X
Translational Oncology 13 (2): 221-232. February 2020

Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma.
Koche, R.P. ORCID: https://orcid.org/0000-0002-6820-5083, Rodriguez-Fos, E. ORCID: https://orcid.org/0000-0002-2555-0178, Helmsauer, K. ORCID: https://orcid.org/0000-0003-0773-4114, Burkert, M. ORCID: https://orcid.org/0000-0002-6721-9985, MacArthur, I.C., Maag, J., Chamorro, R. ORCID: https://orcid.org/0000-0002-5653-7259, Munoz-Perez, N., Puiggròs, M., Dorado Garcia, H. ORCID: https://orcid.org/0000-0002-2578-3350, Bei, Y. ORCID: https://orcid.org/0000-0002-2104-8025, Röefzaad, C. ORCID: https://orcid.org/0000-0003-2299-6673, Bardinet, V. ORCID: https://orcid.org/0000-0002-9583-7043, Szymansky, A. ORCID: https://orcid.org/0000-0003-4797-4526, Winkler, A., Thole, T., Timme, N., Kasack, K., Fuchs, S. ORCID: https://orcid.org/0000-0001-9619-4329, Klironomos, F. ORCID: https://orcid.org/0000-0003-2627-5662, Thiessen, N., Blanc, E. ORCID: https://orcid.org/0000-0002-4369-0254, Schmelz, K., Künkele, A., Hundsdörfer, P., Rosswog, C., Theissen, J., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Deubzer, H. ORCID: https://orcid.org/0000-0002-6115-4893, Sauer, S. ORCID: https://orcid.org/0000-0002-4794-3693, Toedling, J. ORCID: https://orcid.org/0000-0003-1471-1295, Fischer, M. ORCID: https://orcid.org/0000-0003-1363-1242, Hertwig, F. ORCID: https://orcid.org/0000-0003-4784-6516, Schwarz, R.F. ORCID: https://orcid.org/0000-0001-9155-4268, Eggert, A., Torrents, D., Schulte, J.H. and Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X
Nature Genetics 52 (1): 29-34. January 2020

2019

Current and future treatment strategies for rhabdomyosarcoma.
Chen, C. ORCID: https://orcid.org/0000-0002-1579-024X, Dorado-Garcia, H. ORCID: https://orcid.org/0000-0002-2578-3350, Scheer, M. and Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X
Frontiers in Oncology 9 : 1458. 20 December 2019

CD171- and GD2-specific CAR-T cells potently target retinoblastoma cells in preclinical in vitro testing.
Andersch, L., Radke, J., Klaus, A., Schwiebert, S., Winkler, A., Schumann, E., Grunewald, L., Zirngibl, F., Flemmig, C., Jensen, M.C., Rossig, C., Joussen, A., Henssen, A. ORCID: https://orcid.org/0000-0003-1534-778X, Eggert, A., Schulte, J.H. ORCID: https://orcid.org/0000-0003-0671-1201 and Künkele, A. ORCID: https://orcid.org/0000-0002-8406-5412
BMC Cancer 19 (1): 895. 9 September 2019

Prohibitin is a prognostic marker and therapeutic target to block chemotherapy resistance in Wilms' tumor.
Ortiz, M.V., Ahmed, S., Burns, M., Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X, Hollmann, T.J., MacArthur, I., Gunasekera, S., Gaewsky, L., Bradwin, G., Ryan, J., Letai, A., He, Y., Naranjo, A., Chi, Y.Y., LaQuaglia, M., Heaton, T., Cifani, P., Dome, J.S., Gadd, S., Perlman, E., Mullen, E., Steen, H. and Kentsis, A.
JCI Insight 4 (15): e127098. 8 August 2019

Prohibitin promotes dedifferentiation and is a potential therapeutic target in neuroblastoma.
MacArthur, I.C., Bei, Y. ORCID: https://orcid.org/0000-0002-2104-8025, Garcia, H.D. ORCID: https://orcid.org/0000-0002-2578-3350, Ortiz, M.V., Toedling, J. ORCID: https://orcid.org/0000-0003-1471-1295, Klironomos, F., Rolff, J., Eggert, A., Schulte, J.H. ORCID: https://orcid.org/0000-0003-0671-1201, Kentsis, A. and Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X
JCI Insight 4 (10): e127130. 16 May 2019

Synergistic activity of BET inhibitor MK-8628 and PLK inhibitor Volasertib in preclinical models of medulloblastoma.
Han, Y., Lindner, S., Bei, Y. ORCID: https://orcid.org/0000-0002-2104-8025, Garcia, H.D. ORCID: https://orcid.org/0000-0002-2578-3350, Timme, N., Althoff, K., Odersky, A., Schramm, A., Lissat, A., Künkele, A., Deubzer, H.E. ORCID: https://orcid.org/0000-0002-6115-4893, Eggert, A., Schulte, J.H. ORCID: https://orcid.org/0000-0003-0671-1201 and Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X
Cancer Letters 445 : 24-33. 31 March 2019

2018

TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets.
Decaesteker, B. ORCID: https://orcid.org/0000-0003-2264-781X, Denecker, G. ORCID: https://orcid.org/0000-0002-2515-2911, Van Neste, C. ORCID: https://orcid.org/0000-0002-5958-5731, Dolman, E.M., Van Loocke, W., Gartlgruber, M., Nunes, C. ORCID: https://orcid.org/0000-0002-8564-6171, De Vloed, F. ORCID: https://orcid.org/0000-0002-1130-7900, Depuydt, P. ORCID: https://orcid.org/0000-0003-2956-6457, Verboom, K. ORCID: https://orcid.org/0000-0002-8534-2995, Rombaut, D. ORCID: https://orcid.org/0000-0001-7526-7541, Loontiens, S. ORCID: https://orcid.org/0000-0002-4602-4580, De Wyn, J. ORCID: https://orcid.org/0000-0002-0495-1570, Kholosy, W.M., Koopmans, B., Essing, A.H.W. ORCID: https://orcid.org/0000-0002-3314-2828, Herrmann, C., Dreidax, D. ORCID: https://orcid.org/0000-0002-5330-2972, Durinck, K., Deforce, D. ORCID: https://orcid.org/0000-0002-0635-661X, van Nieuwerburgh, F. ORCID: https://orcid.org/0000-0001-8815-5485, Henssen, A. ORCID: https://orcid.org/0000-0003-1534-778X, Versteeg, R. ORCID: https://orcid.org/0000-0001-7172-0388, Boeva, V. ORCID: https://orcid.org/0000-0002-4382-7185, Schleiermacher, G. ORCID: https://orcid.org/0000-0002-0133-5879, van Nes, J. ORCID: https://orcid.org/0000-0001-7691-1431, Mestdagh, P., Vanhauwaert, S. ORCID: https://orcid.org/0000-0002-7768-4549, Schulte, J.H. ORCID: https://orcid.org/0000-0003-0671-1201, Westermann, F., Molenaar, J.J., De Preter, K. and Speleman, F. ORCID: https://orcid.org/0000-0002-6628-8559
Nature Communications 9 (1): 4866. 19 November 2018

Emerging functions of DNA transposases and oncogenic mutators in childhood cancer development.
Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X and Kentsis, A.
JCI Insight 3 (20): 123172. 18 October 2018

2017

Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors.
Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X, Reed, C., Jiang, E., Garcia, H.D., von Stebut, J., MacArthur, I.C., Hundsdoerfer, P., Kim, J.H., de Stanchina, E., Kuwahara, Y., Hosoi, H., Ganem, N.J., Dela Cruz, F., Kung, A.L., Schulte, J.H. ORCID: https://orcid.org/0000-0003-0671-1201, Petrini, J.H. and Kentsis, A.
Science Translational Medicine 9 (414): eaam9078. 1 November 2017

PGBD5 promotes site-specific oncogenic mutations in human tumors.
Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X, Koche, R., Zhuang, J., Jiang, E., Reed, C., Eisenberg, A., Still, E., MacArthur, I.C., Rodriguez-Fos, E. ORCID: https://orcid.org/0000-0002-2555-0178, Gonzalez, S., Puiggròs, M., Blackford, A.N., Mason, C.E., de Stanchina, E., Gönen, M., Emde, A.K., Shah, M., Arora, K., Reeves, C., Socci, N.D., Perlman, E., Antonescu, C.R., Roberts, C.W.M., Steen, H., Mullen, E., Jackson, S.P. ORCID: https://orcid.org/0000-0001-9317-7937, Torrents, D., Weng, Z., Armstrong, S.A. and Kentsis, A. ORCID: https://orcid.org/0000-0002-8063-9191
Nature Genetics 49 (7): 1005-1014. July 2017

Targeting tachykinin receptors in neuroblastoma.
Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X, Odersky, A., Szymansky, A. ORCID: https://orcid.org/0000-0003-4797-4526, Seiler, M., Althoff, K., Beckers, A., Speleman, F., Schäfers, S., De Preter, K., Astrahanseff, K., Struck, J., Schramm, A., Eggert, A., Bergmann, A. and Schulte, J.H. ORCID: https://orcid.org/0000-0003-0671-1201
Oncotarget 8 (1): 430-443. 3 January 2017

2016

Forward genetic screen of human transposase genomic rearrangements.
Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X, Jiang, E., Zhuang, J., Pinello, L., Socci, N.D., Koche, R., Gonen, M., Villasante, C.M., Armstrong, S.A., Bauer, D.E., Weng, Z. and Kentsis, A. ORCID: https://orcid.org/0000-0002-8063-9191
BMC Genomics 17 : 548. 4 August 2016

Targeting MYCN-driven transcription by BET-bromodomain inhibition.
Henssen, A. ORCID: https://orcid.org/0000-0003-1534-778X, Althoff, K., Odersky, A., Beckers, A., Koche, R., Speleman, F., Schäfers, S., Bell, E., Nortmeyer, M., Westermann, F., De Preter, K., Florin, A., Heukamp, L., Spruessel, A., Astrahanseff, K., Lindner, S., Sadowski, N., Schramm, A., Astorgues-Xerri, L., Riveiro, M.E., Eggert, A., Cvitkovic, E. and Schulte, J.H. ORCID: https://orcid.org/0000-0003-0671-1201
Clinical Cancer Research 22 (10): 2470-2481. May 2016

Cytoarchitecture and probability maps of the human medial orbitofrontal cortex.
Henssen, A. ORCID: https://orcid.org/0000-0003-1534-778X, Zilles, K., Palomero-Gallagher, N., Schleicher, A., Mohlberg, H., Gerboga, F., Eickhoff, S.B., Bludau, S. and Amunts, K.
Cortex 75 : 87-112. February 2016

2015

Genomic DNA transposition induced by human PGBD5.
Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X, Henaff, E. ORCID: https://orcid.org/0000-0001-7906-9681, Jiang, E., Eisenberg, A.R., Carson, J.R., Villasante, C.M., Ray, M., Still, E., Burns, M., Gandara, J., Feschotte, C., Mason, C.E. and Kentsis, A. ORCID: https://orcid.org/0000-0002-8063-9191
eLife 4 : e10565. 25 September 2015

Mutational dynamics between primary and relapse neuroblastomas.
Schramm, A., Köster, J., Assenov, Y., Althoff, K., Peifer, M., Mahlow, E., Odersky, A., Beisser, D., Ernst, C., Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X, Stephan, H., Schröder, C., Heukamp, L., Engesser, A., Kahlert, Y., Theissen, J., Hero, B., Roels, F., Altmüller, J. ORCID: https://orcid.org/0000-0003-4372-1521, Nürnberg, P., Astrahantseff, K., Gloeckner, C., De Preter, K., Plass, C., Lee, S., Lode, H.N., Henrich, K.O., Gartlgruber, M., Speleman, F., Schmezer, P., Westermann, F., Rahmann, S., Fischer, M., Eggert, A. and Schulte, J.H. ORCID: https://orcid.org/0000-0003-0671-1201
Nature Genetics 47 (8): 872-877. August 2015

Transposon mapping using flanking sequence exponential anchored (FLEA) PCR.
Henssen, A. ORCID: https://orcid.org/0000-0003-1534-778X, Carson, J. and Kentsis, A.
Protocol Exchange : 2015.071. 22 July 2015

2014

ALK pERKs up MYCN in neuroblastoma.
Lindner, S., Henssen, A. ORCID: https://orcid.org/0000-0003-1534-778X, Astrahantseff, K. and Schulte, J.H. ORCID: https://orcid.org/0000-0003-0671-1201
Science Signaling 7 (349): pe27. 28 October 2014

2013

BET bromodomain protein inhibition is a therapeutic option for medulloblastoma.
Henssen, A. ORCID: https://orcid.org/0000-0003-1534-778X, Thor, T., Odersky, A., Heukamp, L., El-Hindy, N., Beckers, A., Speleman, F., Althoff, K., Schäfers, S., Schramm, A., Sure, U., Fleischhack, G., Eggert, A. and Schulte, J.H. ORCID: https://orcid.org/0000-0003-0671-1201
Oncotarget 4 (11): 2080-2095. November 2013