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K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors.
Waltho, A., Popp, O., Lenz, C., Pluska, L., Lambert, M., Dötsch, V., Mertins, P. and Sommer, T.
Life Science Alliance 7 (8): e202402740. August 2024

Efficient determination of the accessible conformation space of multi-domain complexes based on EPR PELDOR data.
Kazemi, S., Lopata, A., Kniss, A., Pluska, L., Güntert, P., Sommer, T., Prisner, T.F., Collauto, A. and Dötsch, V.
Journal of Biomolecular NMR 77 (5-6): 261-269. December 2023

The DZHK research platform: maximisation of scientific value by enabling access to health data and biological samples collected in cardiovascular clinical studies.
Hoffmann, J., Hanß, S., Kraus, M., Schaller, J., Schäfer, C., Stahl, D., Anker, S.D., Anton, G., Bahls, T., Blankenberg, S., Blumentritt, A., Boldt, L.H., Cordes, S., Desch, S., Doehner, W., Dörr, M., Edelmann, F., Eitel, I., Endres, M., Engelhardt, S., Erdmann, J., Eulenburg, K., Falk, V., Felix, S.B., Frank, D., Franke, T., Frey, N., Friede, T., Geidel, L., Germans, L., Grabmaier, U., Halle, M., Hausleiter, J., Jakobi, V., Jebran, A.F., Jobs, A., Kääb, S., Karakas, M., Katus, H.A., Klatt, A., Knosalla, C., Krebser, J., Landmesser, U., Lee, M., Lehnert, K., Lesser, S., Leyh, K., Lorbeer, R., Mach-Kolb, S., Meder, B., Nagel, E., Nolte, C.H., Parwani, A.S., Petersmann, A., Puls, M., Rau, H., Reiser, M., Rienhoff, O., Scharfe, T., Schattschneider, M., Scheel, H., Schnabel, R.B., Schuster, A., Schmitt, B., Seidler, T., Seiffert, M., Stähli, B.E., Stas, A., Stocker, T.J., von Stülpnagel, L., Thiele, H., Wachter, R., Wakili, R., Weis, T., Weitmann, K., Wichmann, H.E., Wild, P., Zeller, T., Hoffmann, W., Zeisberg, E.M., Zimmermann, W.H., Krefting, D., Kühne, T., Peters, A., Hasenfuß, G., Massberg, S., Sommer, T., Dimmeler, S., Eschenhagen, T. and Nauck, M.
Clinical Research in Cardiology 112 (7): 923-941. July 2023

Thioester and oxyester linkages in the ubiquitin system.
Ferri-Blazquez, A., Jarosch, E. and Sommer, T.
Methods in Molecular Biology 2602 : 3-18. 2023

The UBA domain of conjugating enzyme Ubc1/Ube2K facilitates assembly of K48/K63‐branched ubiquitin chains.
Pluska, L., Jarosch, E., Zauber, H., Kniss, A., Waltho, A., Bagola, K., von Delbrück, M., Löhr, F., Schulman, B.A., Selbach, M., Dötsch, V. and Sommer, T.
EMBO Journal 40 (6): e106094. 15 March 2021

Who with whom: functional coordination of E2 enzymes by RING E3 ligases during poly-ubiquitylation.
Lips, C., Ritterhoff, T., Weber, A., Janowska, M.K., Mustroph, M., Sommer, T. and Klevit, R.E.
EMBO Journal 39 (22): e104863. 16 November 2020

Serum amyloid A1 mediates myotube atrophy via Toll-like receptors.
Hahn, A., Kny, M., Pablo-Tortola, C., Todiras, M., Willenbrock, M., Schmidt, S., Schmoeckel, K., Jorde, I., Nowak, M., Jarosch, E., Sommer, T., Bröker, B.M., Felix, S.B., Scheidereit, C., Weber-Carstens, S., Butter, C., Luft, F.C. and Fielitz, J.
Journal of Cachexia Sarcopenia and Muscle 11 (1): 103-119. February 2020

DCAF8, a novel MuRF1 interaction partner, promotes muscle atrophy.
Nowak, M., Suenkel, B., Porras, P., Migotti, R., Schmidt, F., Kny, M., Zhu, X., Wanker, E.E., Dittmar, G., Fielitz, J. and Sommer, T.
Journal of Cell Science 132 (17): jcs233395. 6 September 2019

Structural investigation of glycan recognition by the ERAD quality control lectin Yos9.
Kniss, A., Kazemi, S., Löhr, F., Berger, M., Rogov, V.V., Güntert, P., Sommer, T., Jarosch, E. and Dötsch, V.
Journal of Biomolecular NMR 72 (1-2): 1-10. October 2018

Chain assembly and disassembly processes differently affect the conformational space of ubiquitin chains.
Kniss, A., Schuetz, D., Kazemi, S., Pluska, L., Spindler, P.E., Rogov, V.V., Husnjak, K., Dikic, I., Güntert, P., Sommer, T., Prisner, T.F. and Dötsch, V.
Structure 26 (2): 249-258. 6 February 2018

Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity.
Wetzel, C., Pifferi, S., Picci, C., Gök, C., Hoffmann, D., Bali, K.K., Lampe, A., Lapatsina, L., Fleischer, R., Smith, E.S.J., Bégay, V., Moroni, M., Estebanez, L., Kühnemund, J., Walcher, J., Specker, E., Neuenschwander, M., von Kries, J.P., Haucke, V., Kuner, R., Poulet, J.F.A., Schmoranzer, J., Poole, K. and Lewin, G.R.
Nature Neuroscience 20 (2): 209-218. February 2017

OPA1 functionally interacts with MIC60 but is dispensable for crista junction formation.
Barrera, M., Koob, S., Dikov, D., Vogel, F. and Reichert, A.S.
FEBS Letters 590 (19): 3309-3322. October 2016

Sequential poly-ubiquitylation by specialized conjugating enzymes expands the versatility of a quality control ubiquitin ligase.
Weber, A., Cohen, I., Popp, O., Dittmar, G., Reiss, Y., Sommer, T., Ravid, T. and Jarosch, E.
Molecular Cell 63 (5): 827-839. 1 September 2016

Numerous proteins with unique characteristics are degraded by the 26S proteasome following monoubiquitination.
Braten, O., Livneh, I., Ziv, T., Admon, A., Kehat, I., Caspi, L.H., Gonen, H., Bercovich, B., Godzik, A., Jahandideh, S., Jaroszewski, L., Sommer, T., Kwon, Y.T., Guharoy, M., Tompa, P. and Ciechanover, A.
Proceedings of the National Academy of Sciences of the United States of America 113 (32): E4639-E4647. 9 August 2016

The CUE domain of Cue1 aligns growing ubiquitin chains with Ubc7 for rapid elongation.
von Delbrück, M., Kniss, A., Rogov, V.V., Pluska, L., Bagola, K., Löhr, F., Güntert, P., Sommer, T. and Dötsch, V.
Molecular Cell 62 (6): 918-928. 16 June 2016

A complex of Htm1 and the oxidoreductase Pdi1 accelerates degradation of misfolded glycoproteins.
Pfeiffer, A., Stephanowitz, H., Krause, E., Volkwein, C., Hirsch, C., Jarosch, E. and Sommer, T.
Journal of Biological Chemistry 291 (23): 12195-12207. 3 June 2016

Muscle RING-finger 2 and 3 maintain striated-muscle structure and function.
Lodka, D., Pahuja, A., Geers-Knörr, C., Scheibe, R., Nowak, M., Hamati, J., Köhncke, C., Purfürst, B., Kanashova, T., Schmidt, S., Glass, D.J., Morano, I., Heuser, A., Kraft, T., Bassel-Duby, R., Olson, E.N., Dittmar, G., Sommer, T. and Fielitz, J.
Journal of Cachexia Sarcopenia and Muscle 7 (2): 165-180. May 2016

KPC1-mediated ubiquitination and proteasomal processing of NF-κB1 p105 to p50 restricts tumor growth.
Kravtsova-Ivantsiv, Y., Shomer, I., Cohen-Kaplan, V., Snijder, B., Superti-Furga, G., Gonen, H., Sommer, T., Ziv, T., Admon, A., Naroditsky, I., Jbara, M., Brik, A., Pikarsky, E., Kwon, Y.T., Doweck, I. and Ciechanover, A.
Cell 161 (2): 333-347. 9 April 2015

Disassembly of Lys11- and mixed-linkage polyubiquitin conjugates provide insights into function of proteasomal deubiquitinases Rpn11 and Ubp6.
Mansour, W., Nakasone, M.A., von Delbrück, M., Yu, Z., Krutauz, D., Reis, N., Kleifeld, O., Sommer, T., Fushman, D. and Glickman, M.H.
Journal of Biological Chemistry 290 (8): 4688-4704. 20 February 2015

The interplay of Hrd3 and the molecular chaperone system ensures efficient degradation of malfolded secretory proteins.
Mehnert, M., Sommermeyer, F., Berger, M., Lakshmipathy, S.K., Gauss, R., Aebi, M., Jarosch, E. and Sommer, T.
Molecular Biology of the Cell 26 (2): 185-194. 15 January 2015

Hexosamine pathway metabolites enhance protein quality control and prolong life.
Denzel, M.S., Storm, N.J., Gutschmidt, A., Baddi, R., Hinze, Y., Jarosch, E., Sommer, T., Hoppe, T. and Antebi, A.
Cell 156 (6): 1167-1178. 13 March 2014

Der1 promotes movement of misfolded proteins through the endoplasmic reticulum membrane.
Mehnert, M., Sommer, T. and Jarosch, E.
Nature Cell Biology 16 (1): 77-86. January 2014

Ubiquitin binding by a CUE domain regulates ubiquitin chain formation by ERAD E3 ligases.
Bagola, K., von Delbrück, M., Dittmar, G., Scheffner, M., Ziv, I., Glickman, M.H., Ciechanover, A. and Sommer, T.
Molecular Cell 50 (4): 528-539. 23 May 2013

The lysine48-based polyubiquitin chain proteasomal signal: not a single child anymore.
Kravtsova-Ivantsiv, Y., Sommer, T. and Ciechanover, A.
Angewandte Chemie International Edition 52 (1): 192-198. 2 January 2013

The size of the proteasomal substrate determines whether its degradation will be mediated by mono- or polyubiquitylation.
Shabek, N., Herman-Bachinsky, Y., Buchsbaum, S., Lewinson, O., Haj-Yahya, M., Hejjaoui, M., Lashuel, H.A., Sommer, T., Brik, A. and Ciechanover, A.
Molecular Cell 48 (1): 87-97. 12 October 2012

The ubiquitin-proteasome system of Saccharomyces cerevisiae.
Finley, D., Ulrich, H.D., Sommer, T. and Kaiser, P.
Genetics 192 (2): 319-360. 1 October 2012

Structural and biochemical basis of Yos9 protein dimerization and possible contribution to self-association of 3-hydroxy-3-methylglutaryl-coenzyme A reductase degradation ubiquitin-ligase complex.
Hanna, J., Schütz, A., Zimmermann, F., Behlke, J., Sommer, T. and Heinemann, U.
Journal of Biological Chemistry 287 (11): 8633-8640. 9 March 2012

Yos9p assists in the degradation of certain non-glycosylated proteins from the endoplasmic reticulum.
Jaenicke, L.A., Brendebach, H., Selbach, M. and Hirsch, C.
Molecular Biology of the Cell 22 (16): 2937-2945. August 2011

Usa1 functions as a scaffold of the HRD-ubiquitin ligase.
Horn, S.C., Hanna, J., Hirsch, C., Volkwein, C., Schütz, A., Heinemann, U., Sommer, T. and Jarosch, E.
Molecular Cell 36 (5): 782-793. 11 December 2009

Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation.
Lutz, A.K., Exner, N., Fett, M.E., Schlehe, J.S., Kloos, K., Laemmermann, K., Brunner, B., Kurz-Drexler, A., Vogel, F., Reichert, A.S., Bouman, L., Vogt-Weisenhorn, D., Wurst, W., Tatzelt, J., Haass, C. and Winklhofer, K.F.
Journal of Biological Chemistry 284 (34): 22938-22951. 21 August 2009

Distinct roles of the two isoforms of the dynamin-like GTPase Mgm1 in mitochondrial fusion.
Zick, M., Duvezin-Caubet, S., Schaefer, A., Vogel, F., Neupert, W. and Reichert, A.S.
FEBS Letters 583 (13): 2237-2243. 7 July 2009

Formation of cristae and crista junctions in mitochondria depends on antagonism between Fcj1 and Su e/g.
Rabl, R., Soubannier, V., Scholz, R., Vogel, F., Mendl, N., Vasiljev-Neumeyer, A., Koerner, C., Jagasia, R., Keil, T., Baumeister, W., Cyrklaff, M., Neupert, W. and Reichert, A.S.
Journal of Cell Biology 185 (6): 1047-1063. 15 June 2009

Mrpl36 is important for generation of assembly competent proteins during mitochondrial translation.
Prestele, M., Vogel, F., Reichert, A.S., Herrmann, J.M. and Ott, M.
Molecular Biology of the Cell 20 (10): 2615-2625. May 2009

Htm1 protein generates the N-glycan signal for glycoprotein degradation in the endoplasmic reticulum.
Clerc, S., Hirsch, C., Oggier, D.M., Deprez, P., Jakob, C., Sommer, T. and Aebi, M.
Journal of Cell Biology 184 (1): 159-172. 12 January 2009

The nuclear export receptor Xpo1/Crm1 is physically and functionally linked to the spindle pole body in budding yeast.
Neuber, A., Franke, J., Wittstruck, A., Schlenstedt, G., Sommer, T. and Stade, K.
Molecular and Cellular Biology 28 (17): 5348-5358. September 2008

Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin.
Exner, N., Treske, B., Paquet, D., Holmstroem, K., Schiesling, C., Gispert, S., Carballo-Carbajal, I., Berg, D., Hoepken, H.H., Gasser, T., Krueger, R., Winklhofer, K.F., Vogel, F., Reichert, A.S., Auburger, G., Kahle, P.J., Schmid, B. and Haass, C.
Journal of Neuroscience 27 (45): 12413-12418. 7 November 2007

Topoisomerase II binds importin alpha isoforms and exportin/CRM1 but does not shuttle between the nucleus and cytoplasm in proliferating cells.
Mirski, S.E.L., Sparks, K.E., Friedrich, B., Koehler, M., Mo, Y.Y., Beck, W.T. and Cole, S.P.C.
Experimental Cell Research 313 (3): 627-637. 1 February 2007

Nuclear localization signal and protein context both mediate importin α specificity of nuclear import substrates.
Friedrich, B., Quensel, C., Sommer, T., Hartmann, E. and Koehler, M.
Molecular and Cellular Biology 26 (23): 8697-8709. December 2006

Dynamic subcompartmentalization of the mitochondrial inner membrane.
Vogel, F., Bornhoevd, C., Neupert, W. and Reichert, A.S.
Journal of Cell Biology 175 (2): 237-247. 23 October 2006

A complex of Yos9p and the HRD ligase integrates endoplasmic reticulum quality control into the degradation machinery.
Gauss, R., Jarosch, E., Sommer, T. and Hirsch, C.
Nature Cell Biology 8 (8): 849-854. August 2006

Mitochondrial membrane potential is dependent on the oligomeric state of F1F0-ATP synthase supracomplexes.
Bornhoevd, C., Vogel, F., Neupert, W. and Reichert, A.S.
Journal of Biological Chemistry 281 (20): 13990-13998. 19 May 2006

The Hrd1p ligase complex forms a linchpin between ER-lumenal substrate selection and Cdc48p recruitment.
Gauss, R., Sommer, T. and Jarosch, E.
EMBO Journal 25 (9): 1827-1835. 3 May 2006

Ubx2 links the Cdc48 complex to ER-associated protein degradation.
Neuber, O., Jarosch, E., Volkwein, C., Walter, J. and Sommer, T.
Nature Cell Biology 7 (10): 993-998. 18 September 2005

Mdm31 and Mdm32 are inner membrane proteins required for maintenance of mitochondrial shape and stability of mitochondrial DNA nucleoids in yeast.
Dimmer, K.S., Jakobs, S., Vogel, F., Altmann, K. and Westermann, B.
Journal of Cell Biology 168 (1): 103-115. 3 January 2005

NF-κB is transported into the nucleus by importin α3 and importin α4.
Fagerlund, R., Kinnunen, L., Koehler, M., Julkunen, I. and Melen, K.
Journal of Biological Chemistry 280 (16): 15942-15951. 1 January 2005

New modules for the repeated internal and N-terminal epitope tagging of genes in Saccharomyces cerevisiae.
Gauss, R., Trautwein, M., Sommer, T. and Spang, A.
Yeast 22 (1): 1-12. 1 January 2005

Structure of palmitoylated BET3: insights into TRAPP complex assembly and membrane localization.
Turnbull, A.P., Kuemmel, D., Prinz, B., Holz, C., Schultchen, J., Lang, C., Niesen, F.H., Hofmann, K.P., Delbrueck, H., Behlke, J., Mueller, E.C., Jarosch, E., Sommer, T. and Heinemann, U.
EMBO Journal 24 (5): 875-884. 1 January 2005

In vivo analysis of importin alpha proteins reveals cellular proliferation inhibition and substrate specificity.
Quensel, C., Friedrich, B., Sommer, T., Hartmann, E. and Koehler, M.
Molecular and Cellular Biology 24 (23): 10246-10255. 1 January 2004

Vpu-mediated degradation of CD4 reconstituted in yeast reveals mechanistic differences to cellular ER-associated protein degradation.
Meusser, B. and Sommer, T.
Molecular Cell 14 (2): 247-258. 1 January 2004

The inner membrane protein Mdm33 controls mitochondrial morphology in yeast.
Messerschmitt, M., Jakobs, S., Vogel, F., Fritz, S., Dimmer, K.S., Neupert, W. and Westermann, B.
Journal of Cell Biology 160 (4): 553-564. 18 February 2003

Processing of Mgm1 by the rhomboid-type protease Pcp1 is required for maintenance of mitochondrial morphology and of mitochondrial DNA.
Herlan, M., Vogel, F., Boernhovd, C., Neupert, W. and Reichert, A.S.
Journal of Biological Chemistry 278 (30): 27781-27788. 1 January 2003

ER-Golgi traffic is a prerequisite for efficient ER degradation.
Taxis, C., Vogel, F. and Wolf, D.H.
Molecular Biology of the Cell 13 (6): 1806-1818. 1 June 2002

Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex.
Fujita, Y., Krause, G., Scheffner, M., Zechner, D., Leddy, H.E.M., Behrens, J., Sommer, T. and Birchmeier, W.
Nature Cell Biology 4 (3): 222-231. 1 March 2002

Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48.
Jarosch, E., Taxis, C., Volkwein, C., Bordallo, J., Finley, D., Wolf, D.H. and Sommer, T.
Nature Cell Biology 4 (2): 134-139. 1 February 2002

A lack of SUMO conjugation affects cNLS-dependent nuclear protein import in yeast.
Stade, K., Vogel, F., Schwienhorst, I., Meusser, B., Volkwein, C., Nentwig, B., Dohmen, R.J. and Sommer, T.
Journal of Biological Chemistry 277 (51): 49554-49561. 1 January 2002

A role for mammalian Ubc6 homologues in ER-associated protein degradation.
Lenk, U., Yu, H., Walter, J., Gelman, M.S., Hartmann, E., Kopito, R.R. and Sommer, T.
Journal of Cell Science 115 (14): 3007-3014. 1 January 2002

Functional expression of GFP-linked human heart sodium channel (hH1) and subcellular localization of the alpha subunit in HEK293 cells and dog cardiac myocytes.
Zimmer, T., Biskup, C., Dugarmaa, S., Vogel, F., Steinbis, M., Boehle, T., Wu, Y.S., Dumaine, R. and Benndorf, K.
Journal of Membrane Biology 186 (1): 1-12. 1 January 2002

Functional expression of human mitochondrial CYP11B2 in fission yeast and identification of a new internal electron transfer protein, etp1.
Bureik, M., Schiffler, B., Hiraoka, Y., Vogel, F. and Bernhardt, R.
Biochemistry 41 (7): 2311-2321. 1 January 2002

Renal anaemia of an unusual origin.
Koehler, M., Schneider, W., Goebel, U. and Kettritz, R.
Nephrology Dialysis Transplantation 16 (11): 2263-2264. November 2001

The nuclear export receptor Xpo1p forms distinct complexes with NES transport substrates and the yeast ran binding protein 1 (Yrb1p).
Maurer, P., Redd, M., Solsbacher, J., Bischoff, F.R., Greiner, M., Podtelejnikov, A.V., Mann, M., Stade, K., Weis, K. and Schlenstedt, G.
Molecular Biology of the Cell 12 (3): 539-549. March 2001

Adenoviral E1A protein nuclear import is preferentially mediated by importin alpha3 in vitro.
Koehler, M., Goerlich, D., Hartmann, E. and Franke, J.
Virology 289 : 186-191. 1 January 2001

Evidence for a nuclear passage of nascent polypeptide-associated complex subunits in yeast.
Franke, J., Reimann, B., Hartmann, E., Koehler, M. and Wiedmann, B.
Journal of Cell Science 114 : 2641-2648. 1 January 2001

Increased importin alpha protein expression in diabetic nephropathy.
Koehler, M., Buchwalow, I.B., Alexander, G., Christiansen, M., Shagdarsuren, E., Samoilova, V., Hartmann, E., Mervaala, E.M.A. and Haller, H.
Kidney International 60 : 2263-2273. 1 January 2001

Sec61p-independent degradation of the tail-anchored ER membrane protein Ubc6p.
Walter, J., Urban, J., Volkwein, C. and Sommer, T.
EMBO Journal 20 (12): 3124-3131. 1 January 2001

Thyroid hormone regulates the obesity gene tub.
Koritschoner, N.P., Alvarez-Dolado, M., Kurz, S.M., Heikenwaelder, M.F., Hacker, C., Vogel, F., Munoz, A. and Zenke, M.
EMBO Reports 2 (6): 499-504. 1 January 2001

Dendritic cells conditionally transformed by v-relER oncogene express lymphoid marker genes.
Madruga, J., Briegel, K., Diebold, S., Boehmelt, G., Vogel, F. and Zenke, M.
Immunobiology 202 (4): 394-407. 1 November 2000

Nup2p, a yeast nucleoporin, functions in bidirectional transport of importin alpha.
Solsbacher, J., Maurer, P., Vogel, F. and Schlenstedt, G.
Molecular and Cellular Biology 20 (22): 8468-8479. 1 November 2000

A regulatory link between ER-associated protein degradation and the unfolded-protein response.
Friedlander, R., Jarosch, E., Urban, J., Volkwein, C. and Sommer, T.
Nature Cell Biology 2 (7): 379-384. 1 July 2000

Purification of Saccharomcyes cerevisiae mitochondria devoid of microsomal and cytosolic contaminations.
Meisinger, C., Sommer, T. and Pfanner, N.
Analytical Biochemistry 287 (2): 339-342. 1 January 2000

Ubiquitin-mediated proteolysis of a short lived regulatory protein depends on its cellular localization.
Lenk, U. and Sommer, T.
Journal of Biological Chemistry 275 (50): 39403-39410. 1 January 2000

RanBP3 contains an unusual nuclear localization signal that is imported preferentially by importin-alpha3.
Welch, K., Franke, J., Koehler, M. and Macara, I.G.
Molecular and Cellular Biology 19 (12): 8400-8411. December 1999

Yeast cells allow high-level expression and formation of polyomavirus-like particles.
Sasnauskas, K., Buzaite, O., Vogel, F., Jandrig, B., Razanskas, R., Staniulis, J., Scherneck, S., Kruger, D.H. and Ulrich, R.
Biological Chemistry 380 : 381-386. 1 March 1999

Regulation of endoplasmic reticulum biogenesis in response to cytochrome P450 overproduction.
Sandig, G., Kaergel, E., Menzel, R., Vogel, F., Zimmer, T. and Schunck, W.H.
Drug Metabolism Reviews 31 : 393-410. 1 January 1999

Urokinase-induced mitogenesis is mediated by casein kinase 2 and nucleolin.
Dumler, I., Stepanova, V., Jerke, U., Mayboroda, O.A., Vogel, F., Bouvet, P., Tkachuk, V., Haller, H. and Gulba, D.C.
Current Biology 9 : 1468-1476. 1 January 1999

Unified nomenclature for subunits of the Saccharomyces cerevisiae proteasome regulatory particle.
Finley, D., Tanaka, K., Mann, C., Feldmann, H., Hochstrasser, M., Vierstra, R., Johnston, S., Hampton, R., Haber, J., Mccusker, J., Silver, P., Frontali, L., Thorsness, P., Varshavsky, A., Byers, B., Madura, K., Reed, S.I., Wolf, D., Jentsch, S., Sommer, T., Baumeister, W., Goldberg, A., Fried, V., Rubin, D.M. and Toh-e, A.
Trends in Biochemical Sciences 23 (7): 244-245. 1 July 1998

Role of Cue1p in ubiquitination and degradition at the ER surface.
Biederer, T., Volkwein, C. and Sommer, T.
Science 278 (5344): 1806-1809. 5 December 1997

Inducible membranes in yeast: relations to the unfolded-protein-response pathway.
Menzel, R., Vogel, F., Kaergel, E. and Schunck, W.H.
Yeast 13 : 1211-1229. 1 January 1997

Introduction of plasmid DNA into isolated mitochondria by electroporation. A novel approach toward gene correction for mitochondrial disorders.
Collombet, J.M., Wheeler, V.C., Vogel, F. and Coutelle, C.
Journal of Biological Chemistry 272 : 5342-5347. 1 January 1997

Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation.
Plemper, R.K., Bohmler, S., Bordallo, J., Sommer, T. and Wolf, D.H.
Nature 388 : 891-895. 1 January 1997

Protein quality - a determinant of the intracellular fate of membrane-bound cytochromes P450 in yeast.
Zimmer, T., Vogel, F., Ohta, A., Takagi, M. and Schunck, W.H.
DNA and Cell Biology 16 : 501-514. 1 January 1997

The Srp40 protein plays a dose-sensitive role in preribosome assembly or transport and depends on its carboxy-terminal domain for proper localization to the yeast nucleoskeleton.
Ikonomova, R., Sommer, T. and Kepes, F.
DNA and Cell Biology 16 : 1161-1173. 1 January 1997

Importin provides a link between nuclear protein import and U snRNA export.
Goerlich, D., Kraft, R., Kostka, S., Vogel, F., Hartmann, E., Laskey, R.A., Mattaj, I.W. and Izaurralde, E.
Cell 87 (1): 21-32. 4 October 1996

Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart.
Ruiz, P., Brinkmann, V., Ledermann, B., Behrend, M., Grund, C., Thalhammer, C., Vogel, F., Birchmeier, C., Guenthert, U., Franke, W.W. and Birchmeier, W.
Journal of Cell Biology 135 (1): 215-225. October 1996

A second trimeric complex containing homologs of the Sec61p complex functions in protein transport across the ER membrane of S.cerevisiae.
Finke, K., Plath, K., Panzner, S., Prehn, S., Rapoport, T.A., Hartmann, E. and Sommer, T.
EMBO Journal 15 (7): 1482-1494. 1 January 1996

Candida maltosa NADPH-cytochrome P450 reductase: cloning of a full-length cDNA, heterologous expression in Saccharomyces cerevisiae and function of the N-terminal region for membrane anchoring and proliferation of the endoplasmic reticulum.
Kaergel, E., Menzel, R., Honeck, H., Vogel, F., Boehmer, A. and Schunck, W.H.
Yeast 12 : 333-348. 1 January 1996

Degradation of subunits of the Sec61p complex, an integral component of the ER membrane, by the ubiquitin-proteasome pathway.
Biederer, T., Volkwein, C. and Sommer, T.
EMBO Journal 15 : 2069-2076. 1 January 1996

Topogenesis of a microsomal cytochrome P450 and induction of endoplasmic reticulum membrane proliferation in Saccharomyces cerevisiae.
Menzel, R., Kaergel, E., Vogel, F., Boettcher, C. and Schunck, W.H.
Archives of Biochemistry and Biophysics 330 : 97-109. 1 January 1996

VIP21-Caveolin, a membrane protein constituent of the caveolar coat, oligomerizes in vivo and in vitro.
Monier, S., Parton, R.G., Vogel, F., Behlke, J., Henske, A. and Kurzchalia, T.V.
Molecular Biology of the Cell 6 (7): 911-927. July 1995

Distinct functions for the two importin subunits in nuclear protein import.
Goerlich, D., Vogel, F., Mills, A.D., Hartmann, E. and Laskey, R.A.
Nature 377 : 246-248. 1 January 1995

In vivo reconstitution of highly active Candida maltosa cytochrome P450 monooxygenase systems in inducible membranes of Saccharomyces cerevisiae.
Zimmer, T., Kaminski, K., Scheller, U., Vogel, F. and Schunck, W.H.
DNA and Cell Biology 14 : 619-628. 1 January 1995

Proliferation of intracellular membrane structures upon homologous overproduction of cytochrome P-450 in Candida maltosa.
Ohkuma, M., Park, S.M., Zimmer, T., Menzel, R., Vogel, F., Schunck, W.H., Ohta, A. and Takagi, M.
Biochimica et Biophysica Acta 1236 (1): 163-169. 1 January 1995

Evolutionary conservation of components of the protein translocation complex.
Hartmann, E., Sommer, T., Prehn, S., Goerlich, D., Jentsch, S. and Rapoport, T.A.
Nature 367 : 654-657. 1 January 1994

Production of monoclonal antibodies against epitopes of the main coat protein of filamentous fd phages.
Micheel, B., Heymann, S., Scharte, G., Boettger, V., Vogel, F., Duebel, S., Breitling, F., Little, M. and Behrsing, O.
Journal of Immunological Methods 71 : 103-109. 1 January 1994

Multiple ubiquitin-conjugating enzymes participate in the in vivo degradation of the yeast MATalpha2 repressor.
Chen, P., Johnson, P., Sommer, T., Jentsch, S. and Hochstrasser, M.
Cell 74 (2): 357-369. 30 July 1993

A protein translocation defect linked to ubiquitin conjugation at the endoplasmic reticulum.
Sommer, T. and Jentsch, S.
Nature 365 : 176-179. 1 January 1993

Immunocytochemical localization of alkane-inducible cytochrome P-450 and its NADPH-dependet reductase in the yeast Candida maltosa.
Vogel, F., Gengnagel, C., Kaergel, E., Mueller, H.G. and Schunck, W.H.
European Journal of Cell Biology 57 : 285-291. 1 January 1992

Comparison of two cytochromes P-450 from Candida maltosa: primary structures, substrate specificities, and effects of their expression in Saccharomyces cerevisoae on the proliferation of the endoplasmic reticulum.
Schunck, W.H., Vogel, F., Gross, B., Kaergel, E., Mauersberger, S., Koepke, K., Gengnagel, C. and Mueller, H.G.
European Journal of Cell Biology 55 : 336-345. 1 January 1991

Book Section

Nuclear import and export.
Pannek, A. and Stade, K.
In: Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine ; Vol. 2. Springer, Berlin [u.a.], 1320-1324. ISBN 3-540-44244-8 2006

Proteasomal degradation of misfolded proteins.
Gauss, R., Neuber, O. and Sommer, T.
In: Chaperones. Topics in Current Genetics ; 16 . Springer, Berlin [u.a.], 185-220. ISBN 3-540-32580-8 2006

Ubiquitination.
Sommer, T. and Dittmar, G.
In: Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine ; Vol. 2. Springer, Berlin [u.a.], 1964-1968. ISBN 3-540-44244-8 2006

The ubiquitin system in yeast.
Sommer, T.
In: Proteasomes: the World of Regulatory Proteolysis. Molecular Biology Intelligence ; 12 . Landes Bioscience, Georgetown, TX, 204-215. 1 January 2000

High level expression of integral membrane proteins induces proliferation of the endoplasmic reticulum.
Menzel, R., Kaergel, E., Wolff, C., Vogel, F. and Schunck, W.H.
In: Cytochrome P450. Libbey, Paris, 307-310. 1 January 1994

Selective degradation by the ubiquitin system.
Jentsch, S., Heinlein, R., Jungmann, J., Reins, H.A., Schlenker, S., Seufert, W., Sommer, T. and Springer, S.
In: Posttranscriptional control of gene expression. Springer, Heidelberg. 1 January 1993

Ubiquitin-dependent protein degradation.
Jentsch, S., Hauser, H.P., Heinlein, R., Jungmann, J., Schlenker, S., Seufert, W., Sommer, T. and Springer, S.
In: Protein synthesis and targeting in yeast. NATO ASI series : Ser. H, Cell biology ; 71 . Springer, Heidelberg. ISBN 3-540-56521-3 ; 0-387-56521-3 1 January 1993

Ubiquitin-dependent protein degradation.
Jentsch, S., Seufert, W., Sommer, T., Reins, H.A., Jungmann, J. and Hauser, H.P.
In: DNA replication and the cell cycle. Colloquium der Gesellschaft fuer Biologische Chemie ; 43 . Springer, Berlin. ISBN 3-540-54729-0; 0-387-54729-0 1 January 1992

Thesis

Untersuchungen zur Regulation des Lipidstoffwechsels in Saccharomyces cerevisiae.
Urban, J.
UNSPECIFIED thesis, UNSPECIFIED. 19 October 2001

Review

Mechanisms of substrate processing during ER-associated protein degradation.
Christianson, J.C., Jarosch, E. and Sommer, T.
Nature Reviews Molecular Cell Biology 24 (11): 777-796. November 2023

Getting to the root of branched ubiquitin chains: a review of current methods and functions.
Waltho, A. and Sommer, T.
Methods in Molecular Biology 2602 : 19-38. 2023

Protein quality control and elimination of protein waste: the role of the ubiquitin-proteasome system.
Amm, I., Sommer, T. and Wolf, D.H.
Biochimica et Biophysica Acta - Molecular Cell Research 1843 (1): 182-196. January 2014

Finding the will and the way of ERAD substrate retrotranslocation.
Hampton, R.Y. and Sommer, T.
Current Opinion in Cell Biology 24 (4): 460-466. August 2012

Protein dislocation from the ER.
Bagola, K., Mehnert, M., Jarosch, E. and Sommer, T.
Biochimica et Biophysica Acta - Biomembranes 1808 (3): 925-936. March 2011

Protein quality control in the cytosol and the endoplasmic reticulum: brothers in arms.
Buchberger, A., Bukau, B. and Sommer, T.
Molecular Cell 40 (2): 238-252. 22 October 2010

ERAD ubiquitin ligases: multifunctional tools for protein quality control and waste disposal in the endoplasmic reticulum.
Mehnert, M., Sommer, T. and Jarosch, E.
BioEssays 32 (10): 905-913. October 2010

The ubiquitylation machinery of the endoplasmic reticulum.
Hirsch, C., Gauss, R., Horn, S.C., Neuber, O. and Sommer, T.
Nature 458 (7237): 453-460. 26 March 2009

Coping with stress: cellular relaxation techniques.
Hirsch, C., Gauss, R. and Sommer, T.
Trends in Cell Biology 16 (12): 657-663. December 2006

ERAD: the long road to destruction.
Meusser, B., Hirsch, C., Jarosch, E. and Sommer, T.
Nature Cell Biology 7 (8): 766-772. August 2005

Endoplasmic reticulum-associated protein degradation - one model fits all?
Hirsch, C., Jarosch, E., Sommer, T. and Wolf, D.H.
Biochimica et Biophysica Acta - Molecular Cell Research 1695 (1-3): 215-223. 1 January 2004

Endoplasmic reticulum-associated protein degradation.
Jarosch, E., Lenk, U. and Sommer, T.
International Review of Cytology 223 : 39-81. 2003

Protein dislocation from the endoplasmic reticulum - Pulling out the suspect.
Jarosch, E., Geiss-Friedlander, R., Meusser, B., Walter, J. and Sommer, T.
Traffic 3 (8): 530-536. 1 January 2002

Compartment-specific functions of the ubiquitin-proteasome pathway.
Sommer, T., Jarosch, E. and Lenk, U.
Reviews of Physiology Biochemistry and Pharmacology 142 : 97-160. 2001

Endoplasmic reticulum degradation: reverse protein flow of no return.
Sommer, T. and Wolf, D.H.
FASEB Journal 11 : 1227-1233. 1 January 1997

Genetic analysis of ubiquitin-dependent protein degradation.
Sommer, T. and Seufert, W.
Experientia 48 : 172-178. 15 February 1992

Is the mammary-derived growth inhibitor (MDGI) related 70 kD antigen, identified in nuclei, a nuclear receptor for MDGI or its hydrophobic ligands?
Vogel, F., Mueller, T. and Grosse, R.
Progress in Histochemistry and Cytochemistry : 159-163. 1 January 1992

In situ localization of cytochrome P-450, the first enzyme involved in aliphatic hydrocarbon degradation in the yeast Candida maltosa.
Vogel, F., Kaergel, E. and Schunck, W.H.
Progress in Histochemistry and Cytochemistry 23 : 383-389. 1 January 1991

Letter

Varshavsky's contributions.
Baumeister, W., Bachmair, A., Chau, V., Cohen, R., Coffino, P., DeMartino, G., Deshaies, R., Dohmen, J., Emr, S., Finley, D., Hampton, R., Hill, C., Hochstrasser, M., Huber, R., Jackson, P., Jentsch, S., Johnson, E., Kwon, Y.T., Pagano, M., Pickart, C., Rechsteiner, M., Scheffner, M., Sommer, T., Tansey, W., Tyers, M., Vierstra, R., Weissman, A., Wilkinson, K.D. and Wolf, D.
Science 306 (5700): 1290-1292. 1 January 2004

Editorial

EU-LIFE charter of independent life science research institutes.
Superti-Furga, G., Agostinho, M., Bury, J., Cook, S., Durinx, C., Ender, A., van Luenen, H., Lund, A.H., Medema, R.H., Miączyńska, M., Nickel, D., Pelicci, P.G., Puisieux, A., Ripatti, S., Sander, M., Schubeler, D., Serrano, L., Sommer, T., Sonne-Hansen, K., Tomančák, P., Vives, J., Vontas, J. and Bettencourt-Dias, M.
FEBS Letters 598 (7): 719-724. April 2024

First person - Marcel Nowak and Benjamin Suenkel.
Nowak, M. and Suenkel, B.
Journal of Cell Science 132 (17): jcs237297. September 2019

Nikolai V. Timofeeff-Ressovsky and the Campus Berlin-Buch.
Sommer, T.
Genetics, Evolution and Radiation : ix-xi. 2016

151 years Berliner Klinische Wochenschrift and the 20th anniversary of the Journal of Molecular Medicine.
Ganten, D., Semenza, G. and Sommer, T.
Journal of Molecular Medicine 93 (9): 935-936. September 2015

Rsp5/Nedd4 clears cells of heat-damaged proteins.
Sommer, T., Weber, A. and Jarosch, E.
Nature Cell Biology 16 (12): 1130-1132. 1 December 2014

The ubiquitin-proteasome-system.
Sommer, T. and Wolf, D.H.
Biochimica et Biophysica Acta - Molecular Cell Research 1843 (1): 1. January 2014

Protein quality control: On IPODs and other JUNQ.
Bagola, K. and Sommer, T.
Current Biology 18 (21): R1019-R1021. 11 November 2008

Lectins in the endoplasmic reticulum: the sweet side of protein quality control.
Sommer, T. and Gauss, R.
Developmental Cell 14 (4): 463-464. 15 April 2008

Pardon me - No access without ubiquitin.
Sommer, T. and Jarosch, E.
Developmental Cell 8 (1): 4-5. 1 January 2005

San1p, checking up on nuclear proteins.
Sommer, T. and Hirsch, C.
Cell 120 (6): 734-736. 1 January 2005

Death gives birth to life: the essential role of the ubiquitin-proteasome system in biology.
Wolf, D.H., Sommer, T. and Hilt, W.
Biochimica et Biophysica Acta - Molecular Cell Research 1695 (1-3): 1-2. 1 January 2004

BiP binding keeps ATF6 at bay.
Sommer, T. and Jarosch, E.
Developmental Cell 3 (1): 1-2. 11 July 2002

Comment

Taking out the trash: How misfolded proteins are removed from the endoplasmic reticulum.
Brodsky, J.L., Engelman, D.M., Hendershot, L.M., Piana-Agostinetti, S. and Sommer, T.
Faculty Reviews 11 : 29. 5 October 2022

Other

Stefan Jentsch (1955-2016) Obituary.
Sommer, T., Hoppe, T. and Rape, M.
Cell Press. 15 December 2016

Stefan Jentsch (1955-2016) Obituary.
Sommer, T., Hoppe, T. and Rape, M.
Cell Press. 15 December 2016