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CXCR4 has a dual role in improving the efficacy of BCMA redirected CAR-NK cells in multiple myeloma.
Moles, M.W., Erdlei, H., Menzel, L., Massaro, M., Fiori, A., Bunse, M., Schrimpf, M., Gerlach, K., Gudipati, V., Reiser, J., Mathavan, K., Goodrich, J., Huppa, J.B., Kroenke, J., Valamehr, B., Höpken, U.E. and Rehm, A.
Frontiers in Immunology 15
: 1383136.
24 June 2024
CD19-targeting CAR T cells protect from ANCA-induced acute kidney injury.
Lodka, D., Zschummel, M., Bunse, M., Rousselle, A., Sonnemann, J., Kettritz, R., Höpken, U.E. and Schreiber, A.
Annals of the Rheumatic Diseases 83
(4): 499-507.
12 March 2024
In vitro functionality and endurance of GMP-compliant point-of-care BCMA.CAR-T cells at different timepoints of cryopreservation.
Jiang, G., Neuber, B., Hückelhoven-Krauss, A., Höpken, U., Ding, Y., Sedloev, D., Wang, L., Reichman, A., Eberhardt, F., Wermke, M., Rehm, A., Müller-Tidow, C., Schmitt, A. and Schmitt, M.
International Journal of Molecular Sciences 25
(3): 1394.
23 January 2024
A local subset of mesenchymal cells expressing the transcription factor Osr1 orchestrates lymph node initiation.
Vallecillo-García, P., Orgeur, M., Comai, G., Poehle-Kronnawitter, S., Fischer, C., Gloger, M., Dumas, C.E., Giesecke-Thiel, C., Sauer, S., Tajbakhsh, S., Höpken, U.E. and Stricker, S.
Immunity 56
(6): 1204-1219.
13 June 2023
Quadruple gene-engineered natural killer cells enable multi-antigen targeting for durable antitumor activity against multiple myeloma.
Cichocki, F., Bjordahl, R., Goodridge, J.P., Mahmood, S., Gaidarova, S., Abujarour, R., Davis, Z.B., Merino, A., Tuininga, K., Wang, H., Kumar, A., Groff, B., Witty, A., Bonello, G., Huffman, J., Dailey, T., Lee, T.T., Malmberg, K.J., Walcheck, B., Höpken, U., Rehm, A., Valamehr, B. and Miller, J.S.
Nature Communications 13
(1): 7341.
29 November 2022
EBAG9-silencing exerts an immune checkpoint function without aggravating adverse effects.
Wirges, A., Bunse, M., Joedicke, J.J., Blanc, E., Gudipati, V., Moles, M.W., Shiku, H., Beule, D., Huppa, J.B., Höpken, U.E. and Rehm, A.
Molecular Therapy 30
(11): 3358-3378.
2 November 2022
A novel gene controls a new structure: piggyBac transposable element-derived 1, unique to mammals, controls mammal-specific neuronal paraspeckles.
Raskó, T., Pande, A., Radscheit, K., Zink, A., Singh, M., Sommer, C., Wachtl, G., Kolacsek, O., Inak, G., Szvetnik, A., Petrakis, S., Bunse, M., Bansal, V., Selbach, M., Orbán, T.I., Prigione, A., Hurst, L.D. and Izsvák, Z.
Molecular Biology and Evolution 39
(10): msac175.
October 2022
C/EBPβ regulates lipid metabolism and Pparg isoform 2 expression in alveolar macrophages.
Dörr, D., Obermayer, B., Weiner, J.M., Zimmermann, K., Anania, C., Wagner, L.K., Lyras, E.M., Sapozhnikova, V., Lara-Astiaso, D., Prósper, F., Lang, R., Lupiáñez, D.G., Beule, D., Höpken, U.E., Leutz, A. and Mildner, A.
Science Immunology 7
(75): eabj0140.
September 2022
CXCR4 mediates leukemic cell migration and survival in the testicular microenvironment.
Skroblyn, T., Joedicke, J.J., Pfau, M., Krüger, K., Bourquin, J.P., Izraeli, S., Eckert, C. and Höpken, U.E.
Journal of Pathology 258
(1): 12-25.
September 2022
Antigen receptor-engineered Tregs inhibit CNS autoimmunity in cell therapy using non-redundant immune mechanisms in mice.
Pohar, J., O'Connor, R., Manfroi, B., Behi, M.E., Jouneau, L., Boudinot, P., Bunse, M., Uckert, W., Luka, M., Ménager, M., Liblau, R., Anderton, S.M. and Fillatreau, S.
European Journal of Immunology 52
(8): 1335-1349.
August 2022
Generation of redirected engineered human chimeric antigen receptor (CAR) T cells.
Bunse, M. and Höpken, U.E.
Methods in Molecular Biology 2521
(3): 67-83.
23 June 2022
Analyses of murine lymph node endothelial cell subsets using single-cell RNA sequencing and spectral flow cytometry.
Menzel, L., Zschummel, M. and Rehm, A.
STAR Protocols 3
(2): 101267.
17 June 2022
Pharmacological interventions enhance virus-free generation of TRAC-replaced CAR T cells.
Kath, J., Du, W., Pruene, A., Braun, T., Thommandru, B., Turk, R., Sturgeon, M.L., Kurgan, G.L., Amini, L., Stein, M., Zittel, T., Martini, S., Ostendorf, L., Wilhelm, A., Akyüz, L., Rehm, A., Hoepken, U.E., Pruß, A., Künkele, A., Jacobi, A.M., Volk, H.D., Schmueck-Henneresse, M., Stripecke, R., Reinke, P. and Wagner, D.L.
Molecular Therapy - Methods and Clinical Development 25
: 311-330.
9 June 2022
EBAG9 controls CD8(+) T cell memory formation responding to tumor challenge in mice.
Rehm, A., Wirges, A., Hoser, D., Fischer, C., Herda, S., Gerlach, K., Sauer, S., Willimsky, G. and Hoepken, U.E.
JCI Insight 7
(11): e155534.
8 June 2022
Accelerating clinical scale production of BCMA CAR T cells with defined maturation stages.
Joedicke, J.J., Großkinsky, U., Gerlach, K., Künkele, A., Höpken, U.E. and Rehm, A.
Molecular Therapy - Methods and Clinical Development 24
: 181-198.
10 March 2022
Comparison of FACS and PCR for detection of BCMA-CAR-T cells.
Reichman, A., Kunz, A., Joedicke, J.J., Höpken, U.E., Keib, A., Neuber, B., Sedloev, D., Wang, L., Jiang, G., Hückelhoven-Krauss, A., Eberhardt, F., Müller-Tidow, C., Wermke, M., Rehm, A., Schmitt, M. and Schmitt, A.
International Journal of Molecular Sciences 23
(2): 903.
14 January 2022
Lymphocyte access to lymphoma is impaired by high endothelial venule regression.
Menzel, L., Zschummel, M., Crowley, T., Franke, V., Grau, M., Ulbricht, C., Hauser, A., Siffrin, V., Bajénoff, M., Acton, S.E., Akalin, A., Lenz, G., Willimsky, G., Höpken, U.E. and Rehm, A.
Cell Reports 37
(4): 109878.
26 October 2021
Transcriptional repression of NFKBIA triggers constitutive IKK- and proteasome-independent p65/RelA activation in senescence.
Kolesnichenko, M., Mikuda, N., Höpken, U.E., Kärgel, E., Uyar, B., Tufan, A.B., Milanovic, M., Sun, W., Krahn, I., Schleich, K., von Hoff, L., Hinz, M., Willenbrock, M., Jungmann, S., Akalin, A., Lee, S., Schmidt-Ullrich, R., Schmitt, C.A. and Scheidereit, C.
EMBO Journal 40
(6): e104296.
15 March 2021
CD28 co-stimulus achieves superior CAR T cell effector function against solid tumors than 4-1BB co-stimulus.
Textor, A., Grunewald, L., Anders, K., Klaus, A., Schwiebert, S., Winkler, A., Stecklum, M., Rolff, J., Henssen, A.G., Höpken, U.E., Eggert, A., Schulte, J.H., Jensen, M.C., Blankenstein, T. and Künkele, A.
Cancers 13
(5): 1050.
2 March 2021
CXCR5 CAR-T cells simultaneously target B cell non-Hodgkin's lymphoma and tumor-supportive follicular T helper cells.
Bunse, M., Pfeilschifter, J., Bluhm, J., Zschummel, M., Joedicke, J.J., Wirges, A., Stark, H., Kretschmer, V., Chmielewski, M., Uckert, W., Abken, H., Westermann, J., Rehm, A. and Höpken, U.E.
Nature Communications 12
(1): 240.
11 January 2021
The transcription factor C/EBPβ orchestrates dendritic cell maturation and functionality under homeostatic and malignant conditions.
Scholz, F., Grau, M., Menzel, L., Graband, A., Zapukhlyak, M., Leutz, A., Janz, M., Lenz, G., Rehm, A. and Höpken, U.E.
Proceedings of the National Academy of Sciences of the United States of America 117
(42): 26328-26339.
20 October 2020
Deficiency in IκBα in the intestinal epithelium leads to spontaneous inflammation and mediates apoptosis in the gut.
Mikuda, N., Schmidt-Ullrich, R., Kärgel, E., Golusda, L., Wolf, J., Höpken, U.E., Scheidereit, C., Kühl, A.A. and Kolesnichenko, M.
Journal of Pathology 251
(2): 160-174.
June 2020
Lymphoma angiogenesis is orchestrated by noncanonical signaling pathways.
Gloger, M., Menzel, L., Grau, M., Vion, A.C., Anagnostopoulos, I., Zapukhlyak, M., Gerlach, K., Kammertöns, T., Hehlgans, T., Zschummel, M., Lenz, G., Gerhardt, H., Höpken, U.E. and Rehm, A.
Cancer Research 80
(6): 1316-1329.
March 2020
Age-related gliosis promotes central nervous system lymphoma through CCL19-mediated tumor cell retention.
O'Connor, T., Zhou, X., Kosla, J., Adili, A., Garcia Beccaria, M., Kotsiliti, E., Pfister, D., Johlke, A.L., Sinha, A., Sankowski, R., Schick, M., Lewis, R., Dokalis, N., Seubert, B., Höchst, B., Inverso, D., Heide, D., Zhang, W., Weihrich, P., Manske, K., Wohlleber, D., Anton, M., Hoellein, A., Seleznik, G., Bremer, J., Bleul, S., Augustin, H.G., Scherer, F., Koedel, U., Weber, A., Protzer, U., Förster, R., Wirth, T., Aguzzi, A., Meissner, F., Prinz, M., Baumann, B., Höpken, U.E., Knolle, P.A., von Baumgarten, L., Keller, U. and Heikenwalder, M.
Cancer Cell 36
(3): 250-267.
16 September 2019
Fluorescent labeling of CRISPR/Cas9 RNP for gene knockout in HSPCs and iPSCs reveals an essential role for GADD45b in stress response.
Nasri, M., Mir, P., Dannenmann, B., Amend, D., Skroblyn, T., Xu, Y., Schulze-Osthoff, K., Klimiankou, M., Welte, K. and Skokowa, J.
Blood Advances 3
(1): 63-71.
8 January 2019
CAR T cells with enhanced sensitivity to B cell maturation antigen for the targeting of B cell non-Hodgkin's lymphoma and multiple myeloma.
Bluhm, J., Kieback, E., Marino, S.F., Oden, F., Westermann, J., Chmielewski, M., Abken, H., Uckert, W., Höpken, U.E. and Rehm, A.
Molecular Therapy 26
(8): 1906-1920.
1 August 2018
The splenic marginal zone shapes the phenotype of leukemia B cells and facilitates their niche-specific retention and survival.
Stache, V., Verlaat, L., Gätjen, M., Heinig, K., Westermann, J., Rehm, A. and Höpken, U.E.
OncoImmunology 6
(6): e1323155.
6 June 2017
Rapid eradication of colon carcinoma by Clostridium perfringens Enterotoxin suicidal gene therapy.
Pahle, J., Menzel, L., Niesler, N., Kobelt, D., Aumann, J., Rivera, M. and Walther, W.
BMC Cancer 17
(1): 129.
13 February 2017
Splenic marginal zone granulocytes acquire an accentuated neutrophil B cell-helper phenotype in chronic lymphocytic leukemia.
Gätjen, M., Brand, F., Grau, M., Gerlach, K., Kettritz, R., Westermann, J., Anagnostopoulos, I., Lenz, P., Lenz, G., Höpken, U.E. and Rehm, A.
Cancer Research 76
(18): 5253-5265.
15 September 2016
The transcriptional coactivator Bob1 promotes the development of follicular T helper cells via Bcl6.
Stauss, D., Brunner, C., Berberich-Siebelt, F., Höpken, U.E., Lipp, M. and Müller, G.
EMBO Journal 35
(8): 881-898.
15 April 2016
Dysregulated development of IL-17-and IL-21-expressing follicular helper T cells and increased germinal center formation in the absence of RORγt.
Wichner, K., Stauss, D., Kampfrath, B., Krüger, K., Müller, G., Rehm, A., Lipp, M. and Höpken, U.E.
FASEB Journal 30
(2): 761-774.
February 2016
Loss of Gadkin affects dendritic cell migration in vitro.
Schachtner, H., Weimershaus, M., Stache, V., Plewa, N., Legler, D.F., Höpken, U.E. and Maritzen, T.
PLoS ONE 10
(12): e0143883.
1 December 2015
Potent anti-tumor response by targeting B cell maturation antigen (BCMA) in a mouse model of multiple myeloma.
Oden, F., Marino, S.F., Brand, J., Scheu, S., Kriegel, C., Olal, D., Takvorian, A., Westermann, J., Yilmaz, B., Hinz, M., Daumke, O., Höpken, U.E., Müller, G. and Lipp, M.
Molecular Oncology 9
(7): 1348-1358.
August 2015
Access to follicular dendritic cells is a pivotal step in murine chronic lymphocytic leukemia B cell activation and proliferation.
Heinig, K., Gätjen, M., Grau, M., Stache, V., Anagnostopoulos, I., Gerlach, K., Niesner, R.A., Cseresnyes, Z., Hauser, A.E., Lenz, P., Hehlgans, T., Brink, R., Westermann, J., Dörken, B., Lipp, M., Lenz, G., Rehm, A. and Höpken, U.E.
Cancer Discovery 4
: 1448-1465.
December 2014
Dendritic cell-mediated survival signals in Eμ-Myc B-cell lymphoma depend on the transcription factor C/EBPβ.
Rehm, A., Gätjen, M., Gerlach, K., Scholz, F., Mensen, A., Gloger, M., Heinig, K., Lamprecht, B., Mathas, S., Bégay, V., Leutz, A., Lipp, M., Dörken, B. and Höpken, U.E.
Nature Communications 5
: 5057.
30 September 2014
B-cell-intrinsic STAT6 signaling controls germinal center formation.
Turqueti-Neves, A., Otte, M., da Costa, O.P., Höpken, U.E., Lipp, M., Buch, T. and Voehringer, D.
European Journal of Immunology 44
(7): 2130-2138.
July 2014
Increased levels of CCR7 ligands in carotid atherosclerosis: different effects in macrophages and smooth muscle cells.
Halvorsen, B., Dahl, T.B., Smedbakken, L.M., Singh, A., Michelsen, A.E., Skjelland, M., Krohg-Sørensen, K., Russell, D., Höpken, U.E., Lipp, M., Damås, J.K., Holm, S., Yndestad, A., Biessen, E.A. and Aukrust, P.
Cardiovascular Research 102
(1): 148-156.
1 April 2014
Transition from an autoimmune-prone state to fatal autoimmune disease in CCR7 and RORγt double-deficient mice is dependent on gut microbiota.
Wichner, K., Fischer, A., Winter, S., Tetzlaff, S., Heimesaat, M.M., Bereswill, S., Rehm, A., Lipp, M. and Höpken, U.E.
Journal of Autoimmunity 47
: 58-72.
December 2013
The sorting receptor sortilin exhibits a dual function in exocytic trafficking of interferon-γ and granzyme A in T cells.
Herda, S., Raczkowski, F., Mittruecker, H.W., Willimsky, G., Gerlach, K., Kuehl, A.A., Breiderhoff, T., Willnow, T.E., Doerken, B., Höpken, U.E. and Rehm, A.
Immunity 37
(5): 854-866.
16 November 2012
CCR7 deficiency causes diarrhea associated with altered ion transport in colonocytes in the absence of overt colitis.
Schumann, M., Winter, S., Wichner, K., May, C., Kuehl, A.A., Batra, A., Siegmund, B., Zeitz, M., Schulzke, J.D., Lipp, M. and Höpken, U.E.
Mucosal Immunology 5
(4): 377-387.
July 2012
Manifestation of spontaneous and early autoimmune gastritis in CCR7-deficient mice.
Winter, S., Rehm, A., Wichner, K., Scheel, T., Batra, A., Siegmund, B., Berek, C., Lipp, M. and Höpken, U.E.
American Journal of Pathology 179
(2): 754-765.
August 2011
Cooperative function of CCR7 and lymphotoxin in the formation of a lymphoma-permissive niche within murine secondary lymphoid organs.
Rehm, A., Mensen, A., Schradi, K., Gerlach, K., Wittstock, S., Winter, S., Buechner, G., Doerken, B., Lipp, M. and Höpken, U.E.
Blood 118
(4): 1020-1033.
28 July 2011
The chemokine receptor CXCR5 is pivotal for ectopic mucosa-associated lymphoid tissue neogenesis in chronic Helicobacter pylori-induced inflammation.
Winter, S., Loddenkemper, C., Aebischer, A., Raebel, K., Hoffmann, K., Meyer, T.F., Lipp, M. and Höpken, U.E.
Journal of Molecular Medicine 88
(11): 1169-1180.
November 2010
CCR7 regulates lymphocyte egress and recirculation through body cavities.
Höpken, U.E., Winter, S., Achtman, A.H., Krueger, K. and Lipp, M.
Journal of Leukocyte Biology 87
(4): 671-682.
April 2010
Identification of a chemokine receptor profile characteristic for mediastinal large B-cell lymphoma.
Rehm, A., Anagnostopoulos, I., Gerlach, K., Broemer, M., Scheidereit, C., Joehrens, K., Huebler, M., Hetzer, R., Stein, H., Lipp, M., Doerken, B. and Höpken, U.E.
International Journal of Cancer 125
(10): 2367-2374.
15 November 2009
Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation.
van de Pavert, S.A., Olivier, B.J., Goverse, G., Vondenhoff, M.F., Greuter, M., Beke, P., Kusser, K., Höpken, U.E., Lipp, M., Niederreither, K., Blomhoff, R., Sitnik, K., Agace, W.W., Randall, T.D., de Jonge, W.J. and Mebius, R.E.
Nature Immunology 10
(11): 1193-1199.
November 2009
The tumor-associated antigen EBAG9 negatively regulates the cytolytic capacity of mouse CD8+ T cells.
Rueder, C., Höpken, U.E., Wolf, J., Mittruecker, H.W., Engels, B., Erdmann, B., Wollenzin, S., Uckert, W., Dörken, B. and Rehm, A.
Journal of Clinical Investigation 119
(8): 2184-2203.
August 2009
Brain antigens in functionally distinct antigen-presenting cell populations in cervical lymph nodes in MS and EAE.
van Zwam, M., Huizinga, R., Melief, M.J., Wierenga-Wolf, A.F., van Meurs, M., Voerman, J.S., Biber, K.P., Boddeke, H.W., Höpken, U.E., Meisel, C., Meisel, A., Bechmann, I., Hintzen, R.Q., 't Hart, B.A., Amor, S., Laman, J.D. and Boven, L.A.
Journal of Molecular Medicine 87
(3): 273-286.
March 2009
CCR7-deficient mice develop atypically persistent germinal centers in response to thymus-independent type 2 antigens.
Achtman, A.H., Höpken, U.E., Bernert, C. and Lipp, M.
Journal of Leukocyte Biology 85
(3): 409-417.
March 2009
CXCR5- and CCR7-dependent lymphoid neogenesis in a murine model of chronic antigen-induced arthritis.
Wengner, A.M., Höpken, U.E., Petrow, P.K., Hartmann, S., Schurigt, U., Bräuer, R. and Lipp, M.
Arthritis and Rheumatism 56
(10): 3271-3283.
October 2007
CCL19 (ELC) as an adjuvant for DNA vaccination: induction of a TH1-type T-cell response and enhancement of antitumor immunity.
Westermann, J., Nguyen-Hoai, T., Baldenhofer, G., Höpken, U.E., Lipp, M., Dörken, B. and Pezzutto, A.
Cancer Gene Therapy 14
(6): 523-532.
June 2007
Distinctive role of CCR7 in migration and functional activity of naive- and effector/memory-like Treg subsets.
Menning, A., Höpken, U.E., Siegmund, K., Lipp, M., Hamann, A. and Huehn, J.
European Journal of Immunology 37
(6): 1575-1583.
June 2007
CCR7 deficiency causes ectopic lymphoid neogenesis and disturbed mucosal tissue integrity.
Höpken, U.E., Wengner, A.M., Loddenkemper, C., Stein, H., Heimesaat, M.M., Rehm, A. and Lipp, M.
Blood 109
(3): 886-895.
1 February 2007
Mycobacterium tuberculosis triggers formation of lymphoid structure in murine lungs.
Kahnert, A., Höpken, U.E., Stein, M., Bandermann, S., Lipp, M. and Kaufmann, S.H.
Journal of Infectious Diseases 195
(1): 46-54.
1 January 2007
Salmonella typhimurium infection triggers dendritic cells and macrophages to adopt distinct migration patterns in vivo.
Zhao, C., Wood, M.W., Galyov, E.E., Höpken, U.E., Lipp, M., Bodmer, H.C., Tough, D.F. and Carter, R.W.
European Journal of Immunology 36
(11): 2939-2950.
November 2006
The ratio between dendritic cells and T cells determines the outcome of their encounter: Proliferation versus deletion.
Höpken, U.E., Lehmann, I., Droese, J., Lipp, M., Schueler, T. and Rehm, A.
European Journal of Immunology 35
(10): 2851-2863.
23 September 2005
Differential requirements for the chemokine receptor CCR7 in T cell activation during Listeria monocytogenes infection.
Kursar, M., Höpken, U.E., Koch, M., Koehler, A., Lipp, M., Kaufmann, S.H. and Mittrücker, H.W.
Journal of Experimental Medicine 201
(9): 1447-1457.
2 May 2005
HCMV-encoded chemokine receptor US28 employs multiple routes for internalization.
Droese, J., Mokros, T., Hermosilla, R., Schuelein, R., Lipp, M., Höpken, U.E. and Rehm, A.
Biochemical and Biophysical Research Communications 322
(1): 42-49.
10 September 2004
Distinct and overlapping roles of CXCR5 and CCR7 in B-1 cell homing and early immunity against bacterial pathogens.
Höpken, U.E., Achtman, A.H., Krueger, K. and Lipp, M.
Journal of Leukocyte Biology 76
(3): 709-718.
September 2004
The chemokine receptor CCR7 controls lymph node-dependent cytotoxic T cell priming in alloimmune responses.
Höpken, U.E., Droese, J., Li, J.P., Joergensen, J., Breitfeld, D., Zerwes, H.G. and Lipp, M.
European Journal of Immunology 34
(2): 461-470.
1 January 2004
Regulation of dendritic cell migration to the draining lymph node: Impact on T lymphocyte traffic and priming.
Martin-Fontecha, A., Sebastiani, S., Höpken, U.E., Uguccioni, M., Lipp, M., Lanzavecchia, A. and Sallusto, F.
Journal of Experimental Medicine 198
(4): 615-621.
18 August 2003
Role of homeostatic chemokine and sphingosine-1-phosphate receptors in the organization of lymphoid tissue.
Müller, G., Reiterer, P., Höpken, U.E., Golfier, S. and Lipp, M.
Annals of the New York Academy of Sciences 987
: 107-116.
April 2003
Systemic immunoregulatory and pathogenic functions of homeostatic chemokine receptors.
Müller, G., Höpken, U.E., Stein, H. and Lipp, M.
Journal of Leukocyte Biology 72
(1): 1-8.
July 2002
In vivo differentiated cytokine-producing CD4+ T cells express functional CCR7.
Debes, G.F., Höpken, U.E. and Hamann, A.
Journal of Immunology 168
(11): 5441-5447.
1 June 2002
Human cytomegalovirus gene products US2 and US11 differ in their ability to attack major histocompatibility class I heavy chains in dendritic cells.
Rehm, A., Engelsberg, A., Tortorella, D., Körner, I.J., Lehmann, I., Ploegh, H.L. and Höpken, U.E.
Journal of Virology 76
(10): 5043-5050.
May 2002
Role for CCR7 Ligands in the emigration of newly generated T lymphocytes from the neonatal thymus.
Ueno, T., Hara, K., Willis, M.S., Malin, M.A., Höpken, U.E., Gray, D.H.D., Matsushima, K., Lipp, M., Springer, T.A., Boyd, R.L., Yoshie, O. and Takahama, Y.
Immunity 16
(2): 205-218.
1 January 2002
Surface expression and endocytosis of the human cytomegalovirus-encoded chemokine receptor US28 is regulated by agonist-independent phosphorylation.
Mokros, T., Rehm, A., Droese, J., Oppermann, M., Lipp, M. and Höpken, U.E.
Journal of Biological Chemistry 277
(47): 45122-45128.
1 January 2002
Up-regulation of the chemokine receptor CCR7 in classical but not in lymphocyte-predominant Hodgkin disease correlates with distinct dissemination of neoplastic cells in lymphoid organs.
Höpken, U.E., Foss, H.D., Meyer, D., Hinz, M., Leder, K., Stein, H. and Lipp, M.
Blood 99
(4): 1109-1116.
1 January 2002
Expression of C5a receptor in mouse brain: role in signal transduction and neurodegeneration.
Osaka, H., McGinty, A., Höpken, U.E., Lu, B., Gerard, C. and Pasinetti, G.M.
Neuroscience 88
(4): 1073-1082.
February 1999
Effects of anti-C5a monoclonal antibodies on oxygen use in a porcine model of severe sepsis.
Mohr, M., Höpken, U., Oppermann, M., Mathes, C., Goldmann, K., Siever, S., Goetze, O. and Burchardi, H.
European Journal of Clinical Investigation 28
(3): 227-234.
March 1998
Impaired inflammatory responses in the reverse arthus reaction through genetic deletion of the C5a receptor.
Höpken, U.E., Lu, B., Gerard, N.P. and Gerard, C.
Journal of Experimental Medicine 186
(5): 749-756.
29 August 1997
Alternate splicing of mouse fusin/CXC chemokine receptor-4: stromal cell-derived factor-1α is a ligand for both CXC chemokine receptor-4 isoforms.
Heesen, M., Berman, M.A., Höpken, U.E., Gerard, N.P. and Dorf, M.E.
Journal of Immunology 158
(8): 3561-3564.
15 April 1997
Neurogenic amplification of immune complex inflammation.
Bozic, C.R., Lu, B., Höpken, U.E., Gerard, C. and Gerard, N.P.
Science 273
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20 September 1996
The C5a chemoattractant receptor mediates mucosal defence to infection.
Höpken, U.E., Lu, B., Gerard, N.P. and Gerard, C.
Nature 383
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5 September 1996
Inhibition of interleukin-6 synthesis in an animal model of septic shock by anti-C5a monoclonal antibodies.
Höpken, U., Mohr, M., Strueber, A., Montz, H., Burchardi, H., Götze, O. and Oppermann, M.
European Journal of Immunology 26
(5): 1103-1109.
May 1996
Assessment of complement activation in vivo.
Oppermann, M., Höpken, U. and Götze, O.
Immunopharmacology 24
(2): 119-34.
September 1992
Book Section
B cell localization and migration in health and disease.
Hauser, A.E. and Höpken, U.E.
In:
Molecular Biology of B Cells.
Academic Press, 187-214.
ISBN 978-0-12-397933-9
2015
Review
Angiogenesis in lymph nodes is a critical regulator of immune response and lymphoma growth.
Menzel, L., Höpken, U.E. and Rehm, A.
Frontiers in Immunology 11
: 591741.
3 December 2020
Targeting the tumor microenvironment of leukemia and lymphoma.
Höpken, U.E. and Rehm, A.
Trends in Cancer 5
(6): 351-364.
June 2019
Homeostatic chemokines guide lymphoma cells to tumor growth-promoting niches within secondary lymphoid organs.
Höpken, U.E. and Rehm, A.
Journal of Molecular Medicine 90
(11): 1237-1245.
November 2012
The impact of CCR7 and CXCR5 on lymphoid organ development and systemic immunity.
Müller, G., Höpken, U.E. and Lipp, M.
Immunological Reviews 195
(1): 117-135.
October 2003
Letter
Interruption of the CXCL13/CXCR5 chemokine axis enhances plasma IgM levels and attenuates atherosclerosis development.
van der Vorst, E.P.C., Daissormont, I., Aslani, M., Seijkens, T., Wijnands, E., Lutgens, E., Duchene, J., Santovito, D., Döring, Y., Halvorsen, B., Aukrust, P., Weber, C., Höpken, U.E. and Biessen, E.A.L.
Thrombosis and Haemostasis 120
(2): 344-347.
February 2020
Editorial
Targeting HDAC3 in CREBBP-mutant lymphomas counterstrikes unopposed enhancer deacetylation of B-cell signaling and immune response genes.
Höpken, U.E.
Cancer Discovery 7
(1): 14-16.
January 2017
Lymphotoxin-α keeps the gate open for T-cell infiltration in cHL.
Höpken, U.E.
Blood 124
(19): 2897-2898.
6 November 2014
All roads lead to rome: triggering dendritic cell migration.
Höpken, U.E. and Lipp, M.
Immunity 20
(3): 244-246.
March 2004
Comment
Wie weiblich ist die Onkologie in Deutschland? [How feminine is oncology in Germany?].
Fehm, T., Behrens, B., Friebe, V., Krawczyk, N., Bleckmann, A., Höpken, U., Wardelmann, E., Heinrich, K., Duda, A., Gögel, S., Wesselmann, S., Nothacker, M., Schmalfeldt, B. and Hasenburg, A.
Forum 39
: 212–216.
June 2024
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