Article
Engineered CCR7 overexpression enhances nodal CAR T-cell homing and cytotoxicity toward B-cell lymphoma.
Zschummel, Maria
ORCID: https://orcid.org/0000-0002-4778-8742, Bunse, Mario
ORCID: https://orcid.org/0000-0002-7554-2520, Spierling, Anna-Lena
ORCID: https://orcid.org/0009-0003-0009-7615, Li, Anna
ORCID: https://orcid.org/0000-0002-4702-7783, Joedicke, Jara J.
ORCID: https://orcid.org/0000-0002-4708-3216, Margineanu, Anca
ORCID: https://orcid.org/0000-0002-6634-9729, Blachut, Susanne
ORCID: https://orcid.org/0009-0007-0102-9867, Lindberg, Eric Lars-Helge
ORCID: https://orcid.org/0000-0002-2979-433X, Ruiz-Orera, Jorge
ORCID: https://orcid.org/0000-0002-8317-0034, Hübner, Norbert
ORCID: https://orcid.org/0000-0002-1218-6223, Rehm, Armin
ORCID: https://orcid.org/0000-0001-7490-1950 and Höpken, Uta E.
ORCID: https://orcid.org/0000-0002-0776-4893
Cancer Immunology Research 14
(5): 827-844.
4 May 2026
Bispecific BAFF-R/BCMA CAR T cells control growth of heterogeneous plasma cells in multiple myeloma.
Fiori, Agnese
ORCID: https://orcid.org/0000-0003-0440-4857, Zimmermann, Karin, Li, Anna
ORCID: https://orcid.org/0000-0002-4702-7783, Westermann, Jörg, Anagnostopoulos, Ioannis, Menzel, Lutz
ORCID: https://orcid.org/0000-0002-3816-6255, Bunse, Mario
ORCID: https://orcid.org/0000-0002-7554-2520, Erdlei, Henry, Jayarajan, Jeyan
ORCID: https://orcid.org/0009-0009-6205-143X, Grünschläger, Florian, Ortiz-Aguirre, Juan Pablo
ORCID: https://orcid.org/0000-0002-6557-0069, Haas, Simon
ORCID: https://orcid.org/0000-0001-9227-2051, Teßmann, Uwe-Jens, Freitag, Jens, Rosenwald, Andreas, Kwak, Larry, Wang, Xiuli, Dong, Zhenyuan, Cha, Soungchul, Reiser, John, Peralta, Eigen, Valamehr, Bahram, Krönke, Jan, Höpken, Uta E.
ORCID: https://orcid.org/0000-0002-0776-4893 and Rehm, Armin
ORCID: https://orcid.org/0000-0001-7490-1950
Molecular Therapy 34
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4 March 2026
A protective cGAMP-mediated anti-tumor immune response can proceed without LRRC8/VRAC channels.
Thöne, Fabian M.B.
ORCID: https://orcid.org/0009-0002-5191-9351, Polovitskaya, Maya M.
ORCID: https://orcid.org/0000-0002-8144-9824, Höpken, Uta E.
ORCID: https://orcid.org/0000-0002-0776-4893, Rehm, Armin
ORCID: https://orcid.org/0000-0001-7490-1950 and Jentsch, Thomas J.
ORCID: https://orcid.org/0000-0002-3509-2553
Journal of Biological Chemistry 302
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February 2026
Targeting MYCN upregulates L1CAM tumor antigen in MYCN-dysregulated neuroblastoma to increase CAR T cell efficacy.
Grunewald, L.
ORCID: https://orcid.org/0000-0002-7175-7380, Andersch, L., Helmsauer, K.
ORCID: https://orcid.org/0000-0003-0773-4114, Schwiebert, S., Klaus, A., Henssen, A.G.
ORCID: https://orcid.org/0000-0003-1534-778X, Straka, T., Lodrini, M., Wicha, S.G., Fuchs, S., Hertwig, F.
ORCID: https://orcid.org/0000-0003-4784-6516, Westermann, F., Vitali, A., Caramel, C., Büchel, G., Eilers, M., Astrahantseff, K., Eggert, A., Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893, Schulte, J.H.
ORCID: https://orcid.org/0000-0003-0671-1201, Blankenstein, T.
ORCID: https://orcid.org/0000-0002-3357-4321, Anders, K.
ORCID: https://orcid.org/0000-0002-0429-200X and Künkele, A.
Pharmacological Research 212
: 107608.
February 2025
CXCR4 has a dual role in improving the efficacy of BCMA redirected CAR-NK cells in multiple myeloma.
Moles, M.W., Erdlei, H., Menzel, L.
ORCID: https://orcid.org/0000-0002-3816-6255, Massaro, M., Fiori, A.
ORCID: https://orcid.org/0000-0003-0440-4857, Bunse, M.
ORCID: https://orcid.org/0000-0002-7554-2520, Schrimpf, M., Gerlach, K., Gudipati, V., Reiser, J., Mathavan, K., Goodrich, J., Huppa, J.B., Kroenke, J., Valamehr, B., Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893 and Rehm, A.
ORCID: https://orcid.org/0000-0001-7490-1950
Frontiers in Immunology 15
: 1383136.
24 June 2024
CD19-targeting CAR T cells protect from ANCA-induced acute kidney injury.
Lodka, D.
ORCID: https://orcid.org/0009-0009-3317-6487, Zschummel, M.
ORCID: https://orcid.org/0000-0002-4778-8742, Bunse, M.
ORCID: https://orcid.org/0000-0002-7554-2520, Rousselle, A.
ORCID: https://orcid.org/0000-0002-0641-3143, Sonnemann, J.
ORCID: https://orcid.org/0000-0002-6513-7775, Kettritz, R.
ORCID: https://orcid.org/0000-0001-5821-6718, Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893 and Schreiber, A.
ORCID: https://orcid.org/0000-0003-1244-6379
Annals of the Rheumatic Diseases 83
(4): 499-507.
12 March 2024
In vitro functionality and endurance of GMP-compliant point-of-care BCMA.CAR-T cells at different timepoints of cryopreservation.
Jiang, G., Neuber, B., Hückelhoven-Krauss, A., Höpken, U.
ORCID: https://orcid.org/0000-0002-0776-4893, Ding, Y., Sedloev, D., Wang, L., Reichman, A., Eberhardt, F., Wermke, M., Rehm, A.
ORCID: https://orcid.org/0000-0001-7490-1950, Müller-Tidow, C., Schmitt, A. and Schmitt, M.
ORCID: https://orcid.org/0000-0002-1579-1509
International Journal of Molecular Sciences 25
(3): 1394.
23 January 2024
A local subset of mesenchymal cells expressing the transcription factor Osr1 orchestrates lymph node initiation.
Vallecillo-García, P., Orgeur, M., Comai, G., Poehle-Kronnawitter, S., Fischer, C.
ORCID: https://orcid.org/0000-0003-0329-2435, Gloger, M.
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ORCID: https://orcid.org/0000-0002-4794-3693, Tajbakhsh, S., Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893 and Stricker, S.
Immunity 56
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13 June 2023
Quadruple gene-engineered natural killer cells enable multi-antigen targeting for durable antitumor activity against multiple myeloma.
Cichocki, F.
ORCID: https://orcid.org/0000-0003-3043-0653, Bjordahl, R., Goodridge, J.P., Mahmood, S., Gaidarova, S., Abujarour, R., Davis, Z.B., Merino, A.
ORCID: https://orcid.org/0000-0003-4433-0127, Tuininga, K., Wang, H., Kumar, A., Groff, B., Witty, A., Bonello, G., Huffman, J., Dailey, T., Lee, T.T., Malmberg, K.J.
ORCID: https://orcid.org/0000-0002-8718-9373, Walcheck, B., Höpken, U.
ORCID: https://orcid.org/0000-0002-0776-4893, Rehm, A.
ORCID: https://orcid.org/0000-0001-7490-1950, Valamehr, B.
ORCID: https://orcid.org/0000-0002-5917-3585 and Miller, J.S.
ORCID: https://orcid.org/0000-0002-0339-4944
Nature Communications 13
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29 November 2022
EBAG9-silencing exerts an immune checkpoint function without aggravating adverse effects.
Wirges, A.
ORCID: https://orcid.org/0000-0001-7038-4503, Bunse, M.
ORCID: https://orcid.org/0000-0002-7554-2520, Joedicke, J.J.
ORCID: https://orcid.org/0000-0002-4708-3216, Blanc, E.
ORCID: https://orcid.org/0000-0002-4369-0254, Gudipati, V., Moles, M.W., Shiku, H., Beule, D.
ORCID: https://orcid.org/0000-0002-3284-0632, Huppa, J.B., Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893 and Rehm, A.
ORCID: https://orcid.org/0000-0001-7490-1950
Molecular Therapy 30
(11): 3358-3378.
2 November 2022
A novel gene controls a new structure: piggyBac transposable element-derived 1, unique to mammals, controls mammal-specific neuronal paraspeckles.
Raskó, T., Pande, A.
ORCID: https://orcid.org/0009-0008-0826-973X, Radscheit, K., Zink, A.
ORCID: https://orcid.org/0000-0002-8489-6339, Singh, M.
ORCID: https://orcid.org/0000-0002-8626-5418, Sommer, C., Wachtl, G., Kolacsek, O., Inak, G., Szvetnik, A., Petrakis, S., Bunse, M.
ORCID: https://orcid.org/0000-0002-7554-2520, Bansal, V.
ORCID: https://orcid.org/0000-0002-0944-7226, Selbach, M.
ORCID: https://orcid.org/0000-0003-2454-8751, Orbán, T.I., Prigione, A.
ORCID: https://orcid.org/0000-0001-9457-1952, Hurst, L.D.
ORCID: https://orcid.org/0000-0002-1002-1054 and Izsvák, Z.
ORCID: https://orcid.org/0000-0002-2053-2384
Molecular Biology and Evolution 39
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October 2022
C/EBPβ regulates lipid metabolism and Pparg isoform 2 expression in alveolar macrophages.
Dörr, D.
ORCID: https://orcid.org/0000-0001-8575-7560, Obermayer, B.
ORCID: https://orcid.org/0000-0002-9116-630X, Weiner, J.M.
ORCID: https://orcid.org/0000-0003-1438-7819, Zimmermann, K., Anania, C.
ORCID: https://orcid.org/0000-0003-1549-4157, Wagner, L.K., Lyras, E.M.
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ORCID: https://orcid.org/0000-0001-8686-4675, Prósper, F.
ORCID: https://orcid.org/0000-0001-6115-8790, Lang, R., Lupiáñez, D.G.
ORCID: https://orcid.org/0000-0002-3165-036X, Beule, D.
ORCID: https://orcid.org/0000-0002-3284-0632, Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893, Leutz, A.
ORCID: https://orcid.org/0000-0001-8259-927X and Mildner, A.
ORCID: https://orcid.org/0000-0002-2019-8427
Science Immunology 7
(75): eabj0140.
September 2022
CXCR4 mediates leukemic cell migration and survival in the testicular microenvironment.
Skroblyn, T.
ORCID: https://orcid.org/0000-0002-4281-9087, Joedicke, J.J.
ORCID: https://orcid.org/0000-0002-4708-3216, Pfau, M., Krüger, K., Bourquin, J.P.
ORCID: https://orcid.org/0000-0001-6571-6227, Izraeli, S.
ORCID: https://orcid.org/0000-0002-6938-2540, Eckert, C. and Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893
Journal of Pathology 258
(1): 12-25.
September 2022
Antigen receptor-engineered Tregs inhibit CNS autoimmunity in cell therapy using non-redundant immune mechanisms in mice.
Pohar, J.
ORCID: https://orcid.org/0000-0002-7616-164X, O'Connor, R., Manfroi, B., Behi, M.E., Jouneau, L., Boudinot, P., Bunse, M.
ORCID: https://orcid.org/0000-0002-7554-2520, Uckert, W., Luka, M., Ménager, M., Liblau, R., Anderton, S.M. and Fillatreau, S.
ORCID: https://orcid.org/0000-0002-7730-9917
European Journal of Immunology 52
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August 2022
Generation of redirected engineered human chimeric antigen receptor (CAR) T cells.
Bunse, M.
ORCID: https://orcid.org/0000-0002-7554-2520 and Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893
Methods in Molecular Biology 2521
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23 June 2022
Analyses of murine lymph node endothelial cell subsets using single-cell RNA sequencing and spectral flow cytometry.
Menzel, L.
ORCID: https://orcid.org/0000-0002-3816-6255, Zschummel, M.
ORCID: https://orcid.org/0000-0002-4778-8742 and Rehm, A.
ORCID: https://orcid.org/0000-0001-7490-1950
STAR Protocols 3
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17 June 2022
Pharmacological interventions enhance virus-free generation of TRAC-replaced CAR T cells.
Kath, J., Du, W., Pruene, A., Braun, T., Thommandru, B., Turk, R., Sturgeon, M.L., Kurgan, G.L., Amini, L., Stein, M., Zittel, T., Martini, S., Ostendorf, L., Wilhelm, A., Akyüz, L., Rehm, A.
ORCID: https://orcid.org/0000-0001-7490-1950, Hoepken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893, Pruß, A., Künkele, A., Jacobi, A.M., Volk, H.D., Schmueck-Henneresse, M., Stripecke, R., Reinke, P. and Wagner, D.L.
Molecular Therapy - Methods and Clinical Development 25
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9 June 2022
EBAG9 controls CD8(+) T cell memory formation responding to tumor challenge in mice.
Rehm, A.
ORCID: https://orcid.org/0000-0001-7490-1950, Wirges, A.
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ORCID: https://orcid.org/0000-0002-4794-3693, Willimsky, G.
ORCID: https://orcid.org/0000-0002-9693-948X and Hoepken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893
JCI Insight 7
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8 June 2022
Accelerating clinical scale production of BCMA CAR T cells with defined maturation stages.
Joedicke, J.J.
ORCID: https://orcid.org/0000-0002-4708-3216, Großkinsky, U., Gerlach, K., Künkele, A., Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893 and Rehm, A.
ORCID: https://orcid.org/0000-0001-7490-1950
Molecular Therapy - Methods and Clinical Development 24
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10 March 2022
Comparison of FACS and PCR for detection of BCMA-CAR-T cells.
Reichman, A., Kunz, A., Joedicke, J.J.
ORCID: https://orcid.org/0000-0002-4708-3216, Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893, Keib, A., Neuber, B., Sedloev, D., Wang, L., Jiang, G., Hückelhoven-Krauss, A., Eberhardt, F., Müller-Tidow, C., Wermke, M., Rehm, A.
ORCID: https://orcid.org/0000-0001-7490-1950, Schmitt, M.
ORCID: https://orcid.org/0000-0002-1579-1509 and Schmitt, A.
International Journal of Molecular Sciences 23
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14 January 2022
Lymphocyte access to lymphoma is impaired by high endothelial venule regression.
Menzel, L.
ORCID: https://orcid.org/0000-0002-3816-6255, Zschummel, M.
ORCID: https://orcid.org/0000-0002-4778-8742, Crowley, T.
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ORCID: https://orcid.org/0000-0003-3606-6792, Grau, M., Ulbricht, C.
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ORCID: https://orcid.org/0000-0002-9693-948X, Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893 and Rehm, A.
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Cell Reports 37
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26 October 2021
Transcriptional repression of NFKBIA triggers constitutive IKK- and proteasome-independent p65/RelA activation in senescence.
Kolesnichenko, M.
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ORCID: https://orcid.org/0000-0002-0776-4893, Kärgel, E., Uyar, B.
ORCID: https://orcid.org/0000-0002-3170-4890, Tufan, A.B.
ORCID: https://orcid.org/0000-0002-8734-9736, Milanovic, M.
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ORCID: https://orcid.org/0000-0001-9607-1361, Krahn, I., Schleich, K., von Hoff, L., Hinz, M.
ORCID: https://orcid.org/0000-0003-2611-4121, Willenbrock, M., Jungmann, S., Akalin, A.
ORCID: https://orcid.org/0000-0002-0468-0117, Lee, S.
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ORCID: https://orcid.org/0000-0002-2472-6530, Schmitt, C.A.
ORCID: https://orcid.org/0000-0002-4731-2226 and Scheidereit, C.
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EMBO Journal 40
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15 March 2021
CD28 co-stimulus achieves superior CAR T cell effector function against solid tumors than 4-1BB co-stimulus.
Textor, A.
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ORCID: https://orcid.org/0000-0002-0429-200X, Klaus, A., Schwiebert, S., Winkler, A., Stecklum, M., Rolff, J., Henssen, A.G.
ORCID: https://orcid.org/0000-0003-1534-778X, Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893, Eggert, A., Schulte, J.H.
ORCID: https://orcid.org/0000-0003-0671-1201, Jensen, M.C., Blankenstein, T.
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Cancers 13
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2 March 2021
CXCR5 CAR-T cells simultaneously target B cell non-Hodgkin's lymphoma and tumor-supportive follicular T helper cells.
Bunse, M.
ORCID: https://orcid.org/0000-0002-7554-2520, Pfeilschifter, J.
ORCID: https://orcid.org/0000-0002-4534-0995, Bluhm, J., Zschummel, M.
ORCID: https://orcid.org/0000-0002-4778-8742, Joedicke, J.J.
ORCID: https://orcid.org/0000-0002-4708-3216, Wirges, A.
ORCID: https://orcid.org/0000-0001-7038-4503, Stark, H.
ORCID: https://orcid.org/0000-0002-5726-3958, Kretschmer, V., Chmielewski, M., Uckert, W., Abken, H.
ORCID: https://orcid.org/0000-0002-4302-3240, Westermann, J., Rehm, A.
ORCID: https://orcid.org/0000-0001-7490-1950 and Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893
Nature Communications 12
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11 January 2021
The transcription factor C/EBPβ orchestrates dendritic cell maturation and functionality under homeostatic and malignant conditions.
Scholz, F.
ORCID: https://orcid.org/0000-0002-0253-081X, Grau, M., Menzel, L.
ORCID: https://orcid.org/0000-0002-3816-6255, Graband, A.
ORCID: https://orcid.org/0000-0002-9038-0734, Zapukhlyak, M.
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ORCID: https://orcid.org/0000-0001-7490-1950 and Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893
Proceedings of the National Academy of Sciences of the United States of America 117
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20 October 2020
Deficiency in IκBα in the intestinal epithelium leads to spontaneous inflammation and mediates apoptosis in the gut.
Mikuda, N., Schmidt-Ullrich, R.
ORCID: https://orcid.org/0000-0002-2472-6530, Kärgel, E., Golusda, L., Wolf, J.
ORCID: https://orcid.org/0000-0003-3254-5868, Höpken, U.E.
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ORCID: https://orcid.org/0000-0002-0446-6129, Kühl, A.A. and Kolesnichenko, M.
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Journal of Pathology 251
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June 2020
Lymphoma angiogenesis is orchestrated by noncanonical signaling pathways.
Gloger, M.
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ORCID: https://orcid.org/0000-0002-3816-6255, Grau, M., Vion, A.C.
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Cancer Research 80
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March 2020
Age-related gliosis promotes central nervous system lymphoma through CCL19-mediated tumor cell retention.
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Cancer Cell 36
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16 September 2019
Fluorescent labeling of CRISPR/Cas9 RNP for gene knockout in HSPCs and iPSCs reveals an essential role for GADD45b in stress response.
Nasri, M., Mir, P., Dannenmann, B., Amend, D., Skroblyn, T.
ORCID: https://orcid.org/0000-0002-4281-9087, Xu, Y., Schulze-Osthoff, K., Klimiankou, M., Welte, K. and Skokowa, J.
Blood Advances 3
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8 January 2019
CAR T cells with enhanced sensitivity to B cell maturation antigen for the targeting of B cell non-Hodgkin's lymphoma and multiple myeloma.
Bluhm, J., Kieback, E.
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ORCID: https://orcid.org/0000-0001-5696-9679, Oden, F., Westermann, J., Chmielewski, M., Abken, H., Uckert, W., Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893 and Rehm, A.
ORCID: https://orcid.org/0000-0001-7490-1950
Molecular Therapy 26
(8): 1906-1920.
1 August 2018
The splenic marginal zone shapes the phenotype of leukemia B cells and facilitates their niche-specific retention and survival.
Stache, V.
ORCID: https://orcid.org/0000-0003-3755-6793, Verlaat, L., Gätjen, M., Heinig, K., Westermann, J., Rehm, A.
ORCID: https://orcid.org/0000-0001-7490-1950 and Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893
OncoImmunology 6
(6): e1323155.
6 June 2017
Rapid eradication of colon carcinoma by Clostridium perfringens Enterotoxin suicidal gene therapy.
Pahle, J., Menzel, L.
ORCID: https://orcid.org/0000-0002-3816-6255, Niesler, N., Kobelt, D.
ORCID: https://orcid.org/0000-0002-9373-0648, Aumann, J., Rivera, M. and Walther, W.
ORCID: https://orcid.org/0000-0003-2884-0231
BMC Cancer 17
(1): 129.
13 February 2017
Splenic marginal zone granulocytes acquire an accentuated neutrophil B cell-helper phenotype in chronic lymphocytic leukemia.
Gätjen, M., Brand, F., Grau, M., Gerlach, K., Kettritz, R.
ORCID: https://orcid.org/0000-0001-5821-6718, Westermann, J., Anagnostopoulos, I., Lenz, P., Lenz, G., Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893 and Rehm, A.
ORCID: https://orcid.org/0000-0001-7490-1950
Cancer Research 76
(18): 5253-5265.
15 September 2016
The transcriptional coactivator Bob1 promotes the development of follicular T helper cells via Bcl6.
Stauss, D., Brunner, C., Berberich-Siebelt, F., Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893, Lipp, M.
ORCID: https://orcid.org/0000-0002-0087-2672 and Müller, G.
EMBO Journal 35
(8): 881-898.
15 April 2016
Dysregulated development of IL-17-and IL-21-expressing follicular helper T cells and increased germinal center formation in the absence of RORγt.
Wichner, K., Stauss, D., Kampfrath, B., Krüger, K., Müller, G., Rehm, A.
ORCID: https://orcid.org/0000-0001-7490-1950, Lipp, M.
ORCID: https://orcid.org/0000-0002-0087-2672 and Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893
FASEB Journal 30
(2): 761-774.
February 2016
Loss of Gadkin affects dendritic cell migration in vitro.
Schachtner, H., Weimershaus, M., Stache, V.
ORCID: https://orcid.org/0000-0003-3755-6793, Plewa, N.
ORCID: https://orcid.org/0000-0002-5888-297X, Legler, D.F., Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893 and Maritzen, T.
PLoS ONE 10
(12): e0143883.
1 December 2015
Potent anti-tumor response by targeting B cell maturation antigen (BCMA) in a mouse model of multiple myeloma.
Oden, F., Marino, S.F.
ORCID: https://orcid.org/0000-0001-5696-9679, Brand, J., Scheu, S., Kriegel, C., Olal, D., Takvorian, A., Westermann, J., Yilmaz, B., Hinz, M.
ORCID: https://orcid.org/0000-0003-2611-4121, Daumke, O.
ORCID: https://orcid.org/0000-0002-6190-1414, Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893, Müller, G. and Lipp, M.
ORCID: https://orcid.org/0000-0002-0087-2672
Molecular Oncology 9
(7): 1348-1358.
August 2015
Access to follicular dendritic cells is a pivotal step in murine chronic lymphocytic leukemia B cell activation and proliferation.
Heinig, K., Gätjen, M., Grau, M., Stache, V.
ORCID: https://orcid.org/0000-0003-3755-6793, Anagnostopoulos, I., Gerlach, K., Niesner, R.A.
ORCID: https://orcid.org/0000-0001-8969-5432, Cseresnyes, Z.
ORCID: https://orcid.org/0000-0002-6574-2588, Hauser, A.E., Lenz, P., Hehlgans, T., Brink, R., Westermann, J., Dörken, B.
ORCID: https://orcid.org/0000-0001-7991-3643, Lipp, M.
ORCID: https://orcid.org/0000-0002-0087-2672, Lenz, G., Rehm, A.
ORCID: https://orcid.org/0000-0001-7490-1950 and Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893
Cancer Discovery 4
: 1448-1465.
December 2014
Dendritic cell-mediated survival signals in Eμ-Myc B-cell lymphoma depend on the transcription factor C/EBPβ.
Rehm, A.
ORCID: https://orcid.org/0000-0001-7490-1950, Gätjen, M., Gerlach, K., Scholz, F.
ORCID: https://orcid.org/0000-0002-0253-081X, Mensen, A., Gloger, M.
ORCID: https://orcid.org/0000-0002-3319-7642, Heinig, K., Lamprecht, B., Mathas, S.
ORCID: https://orcid.org/0000-0001-9626-1413, Bégay, V.
ORCID: https://orcid.org/0000-0002-9002-4211, Leutz, A.
ORCID: https://orcid.org/0000-0001-8259-927X, Lipp, M.
ORCID: https://orcid.org/0000-0002-0087-2672, Dörken, B.
ORCID: https://orcid.org/0000-0001-7991-3643 and Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893
Nature Communications 5
: 5057.
30 September 2014
B-cell-intrinsic STAT6 signaling controls germinal center formation.
Turqueti-Neves, A., Otte, M., da Costa, O.P., Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893, Lipp, M.
ORCID: https://orcid.org/0000-0002-0087-2672, Buch, T. and Voehringer, D.
European Journal of Immunology 44
(7): 2130-2138.
July 2014
Increased levels of CCR7 ligands in carotid atherosclerosis: different effects in macrophages and smooth muscle cells.
Halvorsen, B., Dahl, T.B., Smedbakken, L.M., Singh, A., Michelsen, A.E., Skjelland, M., Krohg-Sørensen, K., Russell, D., Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893, Lipp, M.
ORCID: https://orcid.org/0000-0002-0087-2672, Damås, J.K., Holm, S., Yndestad, A., Biessen, E.A. and Aukrust, P.
Cardiovascular Research 102
(1): 148-156.
1 April 2014
Transition from an autoimmune-prone state to fatal autoimmune disease in CCR7 and RORγt double-deficient mice is dependent on gut microbiota.
Wichner, K., Fischer, A., Winter, S.
ORCID: https://orcid.org/0000-0002-4228-4537, Tetzlaff, S., Heimesaat, M.M., Bereswill, S., Rehm, A.
ORCID: https://orcid.org/0000-0001-7490-1950, Lipp, M.
ORCID: https://orcid.org/0000-0002-0087-2672 and Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893
Journal of Autoimmunity 47
: 58-72.
December 2013
The sorting receptor sortilin exhibits a dual function in exocytic trafficking of interferon-γ and granzyme A in T cells.
Herda, S., Raczkowski, F., Mittruecker, H.W., Willimsky, G.
ORCID: https://orcid.org/0000-0002-9693-948X, Gerlach, K., Kuehl, A.A., Breiderhoff, T.
ORCID: https://orcid.org/0000-0002-1676-7498, Willnow, T.E.
ORCID: https://orcid.org/0000-0001-9515-7921, Doerken, B.
ORCID: https://orcid.org/0000-0001-7991-3643, Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893 and Rehm, A.
ORCID: https://orcid.org/0000-0001-7490-1950
Immunity 37
(5): 854-866.
16 November 2012
CCR7 deficiency causes diarrhea associated with altered ion transport in colonocytes in the absence of overt colitis.
Schumann, M., Winter, S.
ORCID: https://orcid.org/0000-0002-4228-4537, Wichner, K., May, C., Kuehl, A.A., Batra, A., Siegmund, B., Zeitz, M., Schulzke, J.D., Lipp, M.
ORCID: https://orcid.org/0000-0002-0087-2672 and Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893
Mucosal Immunology 5
(4): 377-387.
July 2012
Manifestation of spontaneous and early autoimmune gastritis in CCR7-deficient mice.
Winter, S.
ORCID: https://orcid.org/0000-0002-4228-4537, Rehm, A.
ORCID: https://orcid.org/0000-0001-7490-1950, Wichner, K., Scheel, T., Batra, A., Siegmund, B., Berek, C., Lipp, M.
ORCID: https://orcid.org/0000-0002-0087-2672 and Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893
American Journal of Pathology 179
(2): 754-765.
August 2011
Cooperative function of CCR7 and lymphotoxin in the formation of a lymphoma-permissive niche within murine secondary lymphoid organs.
Rehm, A.
ORCID: https://orcid.org/0000-0001-7490-1950, Mensen, A., Schradi, K., Gerlach, K., Wittstock, S., Winter, S.
ORCID: https://orcid.org/0000-0002-4228-4537, Buechner, G., Doerken, B.
ORCID: https://orcid.org/0000-0001-7991-3643, Lipp, M.
ORCID: https://orcid.org/0000-0002-0087-2672 and Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893
Blood 118
(4): 1020-1033.
28 July 2011
The chemokine receptor CXCR5 is pivotal for ectopic mucosa-associated lymphoid tissue neogenesis in chronic Helicobacter pylori-induced inflammation.
Winter, S.
ORCID: https://orcid.org/0000-0002-4228-4537, Loddenkemper, C., Aebischer, A., Raebel, K., Hoffmann, K., Meyer, T.F., Lipp, M.
ORCID: https://orcid.org/0000-0002-0087-2672 and Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893
Journal of Molecular Medicine 88
(11): 1169-1180.
November 2010
CCR7 regulates lymphocyte egress and recirculation through body cavities.
Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893, Winter, S.
ORCID: https://orcid.org/0000-0002-4228-4537, Achtman, A.H., Krueger, K. and Lipp, M.
ORCID: https://orcid.org/0000-0002-0087-2672
Journal of Leukocyte Biology 87
(4): 671-682.
April 2010
Identification of a chemokine receptor profile characteristic for mediastinal large B-cell lymphoma.
Rehm, A.
ORCID: https://orcid.org/0000-0001-7490-1950, Anagnostopoulos, I., Gerlach, K., Broemer, M., Scheidereit, C.
ORCID: https://orcid.org/0000-0002-0446-6129, Joehrens, K., Huebler, M., Hetzer, R., Stein, H., Lipp, M.
ORCID: https://orcid.org/0000-0002-0087-2672, Doerken, B.
ORCID: https://orcid.org/0000-0001-7991-3643 and Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893
International Journal of Cancer 125
(10): 2367-2374.
15 November 2009
Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation.
van de Pavert, S.A., Olivier, B.J., Goverse, G., Vondenhoff, M.F., Greuter, M., Beke, P., Kusser, K., Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893, Lipp, M.
ORCID: https://orcid.org/0000-0002-0087-2672, Niederreither, K., Blomhoff, R., Sitnik, K., Agace, W.W., Randall, T.D., de Jonge, W.J. and Mebius, R.E.
Nature Immunology 10
(11): 1193-1199.
November 2009
The tumor-associated antigen EBAG9 negatively regulates the cytolytic capacity of mouse CD8+ T cells.
Rueder, C., Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893, Wolf, J.
ORCID: https://orcid.org/0000-0003-3254-5868, Mittruecker, H.W., Engels, B.
ORCID: https://orcid.org/0000-0001-9682-2954, Erdmann, B., Wollenzin, S., Uckert, W., Dörken, B.
ORCID: https://orcid.org/0000-0001-7991-3643 and Rehm, A.
ORCID: https://orcid.org/0000-0001-7490-1950
Journal of Clinical Investigation 119
(8): 2184-2203.
August 2009
Brain antigens in functionally distinct antigen-presenting cell populations in cervical lymph nodes in MS and EAE.
van Zwam, M., Huizinga, R., Melief, M.J., Wierenga-Wolf, A.F., van Meurs, M., Voerman, J.S., Biber, K.P., Boddeke, H.W., Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893, Meisel, C., Meisel, A., Bechmann, I., Hintzen, R.Q., 't Hart, B.A., Amor, S., Laman, J.D. and Boven, L.A.
Journal of Molecular Medicine 87
(3): 273-286.
March 2009
CCR7-deficient mice develop atypically persistent germinal centers in response to thymus-independent type 2 antigens.
Achtman, A.H., Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893, Bernert, C. and Lipp, M.
ORCID: https://orcid.org/0000-0002-0087-2672
Journal of Leukocyte Biology 85
(3): 409-417.
March 2009
CXCR5- and CCR7-dependent lymphoid neogenesis in a murine model of chronic antigen-induced arthritis.
Wengner, A.M.
ORCID: https://orcid.org/0009-0009-5772-1945, Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893, Petrow, P.K., Hartmann, S., Schurigt, U., Bräuer, R. and Lipp, M.
ORCID: https://orcid.org/0000-0002-0087-2672
Arthritis and Rheumatism 56
(10): 3271-3283.
October 2007
CCL19 (ELC) as an adjuvant for DNA vaccination: induction of a TH1-type T-cell response and enhancement of antitumor immunity.
Westermann, J., Nguyen-Hoai, T., Baldenhofer, G.
ORCID: https://orcid.org/0000-0002-8480-5652, Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893, Lipp, M.
ORCID: https://orcid.org/0000-0002-0087-2672, Dörken, B.
ORCID: https://orcid.org/0000-0001-7991-3643 and Pezzutto, A.
ORCID: https://orcid.org/0000-0002-3246-4470
Cancer Gene Therapy 14
(6): 523-532.
June 2007
Distinctive role of CCR7 in migration and functional activity of naive- and effector/memory-like Treg subsets.
Menning, A., Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893, Siegmund, K., Lipp, M.
ORCID: https://orcid.org/0000-0002-0087-2672, Hamann, A. and Huehn, J.
European Journal of Immunology 37
(6): 1575-1583.
June 2007
CCR7 deficiency causes ectopic lymphoid neogenesis and disturbed mucosal tissue integrity.
Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893, Wengner, A.M.
ORCID: https://orcid.org/0009-0009-5772-1945, Loddenkemper, C., Stein, H., Heimesaat, M.M., Rehm, A.
ORCID: https://orcid.org/0000-0001-7490-1950 and Lipp, M.
ORCID: https://orcid.org/0000-0002-0087-2672
Blood 109
(3): 886-895.
1 February 2007
Mycobacterium tuberculosis triggers formation of lymphoid structure in murine lungs.
Kahnert, A., Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893, Stein, M., Bandermann, S., Lipp, M.
ORCID: https://orcid.org/0000-0002-0087-2672 and Kaufmann, S.H.
Journal of Infectious Diseases 195
(1): 46-54.
1 January 2007
Salmonella typhimurium infection triggers dendritic cells and macrophages to adopt distinct migration patterns in vivo.
Zhao, C., Wood, M.W., Galyov, E.E., Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893, Lipp, M.
ORCID: https://orcid.org/0000-0002-0087-2672, Bodmer, H.C., Tough, D.F. and Carter, R.W.
European Journal of Immunology 36
(11): 2939-2950.
November 2006
The ratio between dendritic cells and T cells determines the outcome of their encounter: Proliferation versus deletion.
Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893, Lehmann, I., Droese, J., Lipp, M.
ORCID: https://orcid.org/0000-0002-0087-2672, Schueler, T. and Rehm, A.
ORCID: https://orcid.org/0000-0001-7490-1950
European Journal of Immunology 35
(10): 2851-2863.
23 September 2005
Differential requirements for the chemokine receptor CCR7 in T cell activation during Listeria monocytogenes infection.
Kursar, M., Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893, Koch, M., Koehler, A., Lipp, M.
ORCID: https://orcid.org/0000-0002-0087-2672, Kaufmann, S.H. and Mittrücker, H.W.
Journal of Experimental Medicine 201
(9): 1447-1457.
2 May 2005
HCMV-encoded chemokine receptor US28 employs multiple routes for internalization.
Droese, J., Mokros, T., Hermosilla, R., Schuelein, R., Lipp, M.
ORCID: https://orcid.org/0000-0002-0087-2672, Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893 and Rehm, A.
ORCID: https://orcid.org/0000-0001-7490-1950
Biochemical and Biophysical Research Communications 322
(1): 42-49.
10 September 2004
Distinct and overlapping roles of CXCR5 and CCR7 in B-1 cell homing and early immunity against bacterial pathogens.
Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893, Achtman, A.H., Krueger, K. and Lipp, M.
ORCID: https://orcid.org/0000-0002-0087-2672
Journal of Leukocyte Biology 76
(3): 709-718.
September 2004
The chemokine receptor CCR7 controls lymph node-dependent cytotoxic T cell priming in alloimmune responses.
Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893, Droese, J., Li, J.P., Joergensen, J., Breitfeld, D., Zerwes, H.G. and Lipp, M.
ORCID: https://orcid.org/0000-0002-0087-2672
European Journal of Immunology 34
(2): 461-470.
1 January 2004
Regulation of dendritic cell migration to the draining lymph node: Impact on T lymphocyte traffic and priming.
Martin-Fontecha, A., Sebastiani, S., Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893, Uguccioni, M., Lipp, M.
ORCID: https://orcid.org/0000-0002-0087-2672, Lanzavecchia, A. and Sallusto, F.
Journal of Experimental Medicine 198
(4): 615-621.
18 August 2003
Role of homeostatic chemokine and sphingosine-1-phosphate receptors in the organization of lymphoid tissue.
Müller, G., Reiterer, P., Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893, Golfier, S. and Lipp, M.
ORCID: https://orcid.org/0000-0002-0087-2672
Annals of the New York Academy of Sciences 987
: 107-116.
April 2003
Systemic immunoregulatory and pathogenic functions of homeostatic chemokine receptors.
Müller, G., Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893, Stein, H. and Lipp, M.
ORCID: https://orcid.org/0000-0002-0087-2672
Journal of Leukocyte Biology 72
(1): 1-8.
July 2002
In vivo differentiated cytokine-producing CD4+ T cells express functional CCR7.
Debes, G.F., Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893 and Hamann, A.
Journal of Immunology 168
(11): 5441-5447.
1 June 2002
Human cytomegalovirus gene products US2 and US11 differ in their ability to attack major histocompatibility class I heavy chains in dendritic cells.
Rehm, A.
ORCID: https://orcid.org/0000-0001-7490-1950, Engelsberg, A., Tortorella, D., Körner, I.J., Lehmann, I., Ploegh, H.L. and Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893
Journal of Virology 76
(10): 5043-5050.
May 2002
Role for CCR7 Ligands in the emigration of newly generated T lymphocytes from the neonatal thymus.
Ueno, T., Hara, K., Willis, M.S., Malin, M.A., Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893, Gray, D.H.D., Matsushima, K., Lipp, M., Springer, T.A., Boyd, R.L., Yoshie, O. and Takahama, Y.
Immunity 16
(2): 205-218.
1 January 2002
Surface expression and endocytosis of the human cytomegalovirus-encoded chemokine receptor US28 is regulated by agonist-independent phosphorylation.
Mokros, T., Rehm, A.
ORCID: https://orcid.org/0000-0001-7490-1950, Droese, J., Oppermann, M., Lipp, M.
ORCID: https://orcid.org/0000-0002-0087-2672 and Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893
Journal of Biological Chemistry 277
(47): 45122-45128.
1 January 2002
Up-regulation of the chemokine receptor CCR7 in classical but not in lymphocyte-predominant Hodgkin disease correlates with distinct dissemination of neoplastic cells in lymphoid organs.
Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893, Foss, H.D., Meyer, D., Hinz, M., Leder, K., Stein, H. and Lipp, M.
Blood 99
(4): 1109-1116.
1 January 2002
Expression of C5a receptor in mouse brain: role in signal transduction and neurodegeneration.
Osaka, H., McGinty, A., Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893, Lu, B., Gerard, C. and Pasinetti, G.M.
Neuroscience 88
(4): 1073-1082.
February 1999
Effects of anti-C5a monoclonal antibodies on oxygen use in a porcine model of severe sepsis.
Mohr, M., Höpken, U.
ORCID: https://orcid.org/0000-0002-0776-4893, Oppermann, M., Mathes, C., Goldmann, K., Siever, S., Goetze, O. and Burchardi, H.
European Journal of Clinical Investigation 28
(3): 227-234.
March 1998
Impaired inflammatory responses in the reverse arthus reaction through genetic deletion of the C5a receptor.
Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893, Lu, B., Gerard, N.P. and Gerard, C.
Journal of Experimental Medicine 186
(5): 749-756.
29 August 1997
Alternate splicing of mouse fusin/CXC chemokine receptor-4: stromal cell-derived factor-1α is a ligand for both CXC chemokine receptor-4 isoforms.
Heesen, M., Berman, M.A., Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893, Gerard, N.P. and Dorf, M.E.
Journal of Immunology 158
(8): 3561-3564.
15 April 1997
Neurogenic amplification of immune complex inflammation.
Bozic, C.R., Lu, B., Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893, Gerard, C. and Gerard, N.P.
Science 273
(5282): 1722-1725.
20 September 1996
The C5a chemoattractant receptor mediates mucosal defence to infection.
Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893, Lu, B., Gerard, N.P. and Gerard, C.
Nature 383
(6595): 86-89.
5 September 1996
Inhibition of interleukin-6 synthesis in an animal model of septic shock by anti-C5a monoclonal antibodies.
Höpken, U.
ORCID: https://orcid.org/0000-0002-0776-4893, Mohr, M., Strueber, A., Montz, H., Burchardi, H., Götze, O. and Oppermann, M.
European Journal of Immunology 26
(5): 1103-1109.
May 1996
Assessment of complement activation in vivo.
Oppermann, M., Höpken, U.
ORCID: https://orcid.org/0000-0002-0776-4893 and Götze, O.
Immunopharmacology 24
(2): 119-34.
September 1992
Book Section
B cell localization and migration in health and disease.
Hauser, A.E. and Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893
In:
Molecular Biology of B Cells.
Academic Press, 187-214.
ISBN 978-0-12-397933-9
2015
Review
Angiogenesis in lymph nodes is a critical regulator of immune response and lymphoma growth.
Menzel, L.
ORCID: https://orcid.org/0000-0002-3816-6255, Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893 and Rehm, A.
ORCID: https://orcid.org/0000-0001-7490-1950
Frontiers in Immunology 11
: 591741.
3 December 2020
Targeting the tumor microenvironment of leukemia and lymphoma.
Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893 and Rehm, A.
ORCID: https://orcid.org/0000-0001-7490-1950
Trends in Cancer 5
(6): 351-364.
June 2019
Homeostatic chemokines guide lymphoma cells to tumor growth-promoting niches within secondary lymphoid organs.
Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893 and Rehm, A.
ORCID: https://orcid.org/0000-0001-7490-1950
Journal of Molecular Medicine 90
(11): 1237-1245.
November 2012
The impact of CCR7 and CXCR5 on lymphoid organ development and systemic immunity.
Müller, G., Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893 and Lipp, M.
ORCID: https://orcid.org/0000-0002-0087-2672
Immunological Reviews 195
(1): 117-135.
October 2003
Letter
Interruption of the CXCL13/CXCR5 chemokine axis enhances plasma IgM levels and attenuates atherosclerosis development.
van der Vorst, E.P.C., Daissormont, I., Aslani, M., Seijkens, T., Wijnands, E., Lutgens, E., Duchene, J., Santovito, D., Döring, Y., Halvorsen, B., Aukrust, P., Weber, C., Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893 and Biessen, E.A.L.
Thrombosis and Haemostasis 120
(2): 344-347.
February 2020
Editorial
Targeting HDAC3 in CREBBP-mutant lymphomas counterstrikes unopposed enhancer deacetylation of B-cell signaling and immune response genes.
Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893
Cancer Discovery 7
(1): 14-16.
January 2017
Lymphotoxin-α keeps the gate open for T-cell infiltration in cHL.
Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893
Blood 124
(19): 2897-2898.
6 November 2014
All roads lead to rome: triggering dendritic cell migration.
Höpken, U.E.
ORCID: https://orcid.org/0000-0002-0776-4893 and Lipp, M.
ORCID: https://orcid.org/0000-0002-0087-2672
Immunity 20
(3): 244-246.
March 2004
Comment
Wie weiblich ist die Onkologie in Deutschland? [How feminine is oncology in Germany?].
Fehm, T., Behrens, B., Friebe, V., Krawczyk, N., Bleckmann, A., Höpken, U.
ORCID: https://orcid.org/0000-0002-0776-4893, Wardelmann, E., Heinrich, K., Duda, A., Gögel, S., Wesselmann, S., Nothacker, M., Schmalfeldt, B. and Hasenburg, A.
Forum 39
: 212-216.
June 2024
This list was generated on Sun Jul 12 05:57:46 2026 UTC.