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American Journal of Pathology

Manifestation of spontaneous and early autoimmune gastritis in CCR7-deficient mice.
Winter, S. and Rehm, A. and Wichner, K. and Scheel, T. and Batra, A. and Siegmund, B. and Berek, C. and Lipp, M. and Höpken, U.E.
American Journal of Pathology 179 (2): 754-765. August 2011

Annals of the New York Academy of Sciences

Role of homeostatic chemokine and sphingosine-1-phosphate receptors in the organization of lymphoid tissue.
Müller, G. and Reiterer, P. and Höpken, U.E. and Golfier, S. and Lipp, M.
Annals of the New York Academy of Sciences 987 : 107-116. April 2003

Annals of the Rheumatic Diseases

CD19-targeting CAR T cells protect from ANCA-induced acute kidney injury.
Lodka, D. and Zschummel, M. and Bunse, M. and Rousselle, A. and Sonnemann, J. and Kettritz, R. and Höpken, U.E. and Schreiber, A.
Annals of the Rheumatic Diseases 83 (4): 499-507. 12 March 2024

Arthritis and Rheumatism

CXCR5- and CCR7-dependent lymphoid neogenesis in a murine model of chronic antigen-induced arthritis.
Wengner, A.M. and Höpken, U.E. and Petrow, P.K. and Hartmann, S. and Schurigt, U. and Bräuer, R. and Lipp, M.
Arthritis and Rheumatism 56 (10): 3271-3283. October 2007

BMC Cancer

Rapid eradication of colon carcinoma by Clostridium perfringens Enterotoxin suicidal gene therapy.
Pahle, J. and Menzel, L. and Niesler, N. and Kobelt, D. and Aumann, J. and Rivera, M. and Walther, W.
BMC Cancer 17 (1): 129. 13 February 2017

Biochemical and Biophysical Research Communications

HCMV-encoded chemokine receptor US28 employs multiple routes for internalization.
Droese, J. and Mokros, T. and Hermosilla, R. and Schuelein, R. and Lipp, M. and Höpken, U.E. and Rehm, A.
Biochemical and Biophysical Research Communications 322 (1): 42-49. 10 September 2004

Blood

Lymphotoxin-α keeps the gate open for T-cell infiltration in cHL.
Höpken, U.E.
Blood 124 (19): 2897-2898. 6 November 2014

Cooperative function of CCR7 and lymphotoxin in the formation of a lymphoma-permissive niche within murine secondary lymphoid organs.
Rehm, A. and Mensen, A. and Schradi, K. and Gerlach, K. and Wittstock, S. and Winter, S. and Buechner, G. and Doerken, B. and Lipp, M. and Höpken, U.E.
Blood 118 (4): 1020-1033. 28 July 2011

CCR7 deficiency causes ectopic lymphoid neogenesis and disturbed mucosal tissue integrity.
Höpken, U.E. and Wengner, A.M. and Loddenkemper, C. and Stein, H. and Heimesaat, M.M. and Rehm, A. and Lipp, M.
Blood 109 (3): 886-895. 1 February 2007

Up-regulation of the chemokine receptor CCR7 in classical but not in lymphocyte-predominant Hodgkin disease correlates with distinct dissemination of neoplastic cells in lymphoid organs.
Höpken, U.E. and Foss, H.D. and Meyer, D. and Hinz, M. and Leder, K. and Stein, H. and Lipp, M.
Blood 99 (4): 1109-1116. 1 January 2002

Blood Advances

Fluorescent labeling of CRISPR/Cas9 RNP for gene knockout in HSPCs and iPSCs reveals an essential role for GADD45b in stress response.
Nasri, M. and Mir, P. and Dannenmann, B. and Amend, D. and Skroblyn, T. and Xu, Y. and Schulze-Osthoff, K. and Klimiankou, M. and Welte, K. and Skokowa, J.
Blood Advances 3 (1): 63-71. 8 January 2019

Cancer Cell

Age-related gliosis promotes central nervous system lymphoma through CCL19-mediated tumor cell retention.
O'Connor, T. and Zhou, X. and Kosla, J. and Adili, A. and Garcia Beccaria, M. and Kotsiliti, E. and Pfister, D. and Johlke, A.L. and Sinha, A. and Sankowski, R. and Schick, M. and Lewis, R. and Dokalis, N. and Seubert, B. and Höchst, B. and Inverso, D. and Heide, D. and Zhang, W. and Weihrich, P. and Manske, K. and Wohlleber, D. and Anton, M. and Hoellein, A. and Seleznik, G. and Bremer, J. and Bleul, S. and Augustin, H.G. and Scherer, F. and Koedel, U. and Weber, A. and Protzer, U. and Förster, R. and Wirth, T. and Aguzzi, A. and Meissner, F. and Prinz, M. and Baumann, B. and Höpken, U.E. and Knolle, P.A. and von Baumgarten, L. and Keller, U. and Heikenwalder, M.
Cancer Cell 36 (3): 250-267. 16 September 2019

Cancer Discovery

Targeting HDAC3 in CREBBP-mutant lymphomas counterstrikes unopposed enhancer deacetylation of B-cell signaling and immune response genes.
Höpken, U.E.
Cancer Discovery 7 (1): 14-16. January 2017

Access to follicular dendritic cells is a pivotal step in murine chronic lymphocytic leukemia B cell activation and proliferation.
Heinig, K. and Gätjen, M. and Grau, M. and Stache, V. and Anagnostopoulos, I. and Gerlach, K. and Niesner, R.A. and Cseresnyes, Z. and Hauser, A.E. and Lenz, P. and Hehlgans, T. and Brink, R. and Westermann, J. and Dörken, B. and Lipp, M. and Lenz, G. and Rehm, A. and Höpken, U.E.
Cancer Discovery 4 : 1448-1465. December 2014

Cancer Gene Therapy

CCL19 (ELC) as an adjuvant for DNA vaccination: induction of a TH1-type T-cell response and enhancement of antitumor immunity.
Westermann, J. and Nguyen-Hoai, T. and Baldenhofer, G. and Höpken, U.E. and Lipp, M. and Dörken, B. and Pezzutto, A.
Cancer Gene Therapy 14 (6): 523-532. June 2007

Cancer Research

Lymphoma angiogenesis is orchestrated by noncanonical signaling pathways.
Gloger, M. and Menzel, L. and Grau, M. and Vion, A.C. and Anagnostopoulos, I. and Zapukhlyak, M. and Gerlach, K. and Kammertöns, T. and Hehlgans, T. and Zschummel, M. and Lenz, G. and Gerhardt, H. and Höpken, U.E. and Rehm, A.
Cancer Research 80 (6): 1316-1329. March 2020

Splenic marginal zone granulocytes acquire an accentuated neutrophil B cell-helper phenotype in chronic lymphocytic leukemia.
Gätjen, M. and Brand, F. and Grau, M. and Gerlach, K. and Kettritz, R. and Westermann, J. and Anagnostopoulos, I. and Lenz, P. and Lenz, G. and Höpken, U.E. and Rehm, A.
Cancer Research 76 (18): 5253-5265. 15 September 2016

Cancers

CD28 co-stimulus achieves superior CAR T cell effector function against solid tumors than 4-1BB co-stimulus.
Textor, A. and Grunewald, L. and Anders, K. and Klaus, A. and Schwiebert, S. and Winkler, A. and Stecklum, M. and Rolff, J. and Henssen, A.G. and Höpken, U.E. and Eggert, A. and Schulte, J.H. and Jensen, M.C. and Blankenstein, T. and Künkele, A.
Cancers 13 (5): 1050. 2 March 2021

Cardiovascular Research

Increased levels of CCR7 ligands in carotid atherosclerosis: different effects in macrophages and smooth muscle cells.
Halvorsen, B. and Dahl, T.B. and Smedbakken, L.M. and Singh, A. and Michelsen, A.E. and Skjelland, M. and Krohg-Sørensen, K. and Russell, D. and Höpken, U.E. and Lipp, M. and Damås, J.K. and Holm, S. and Yndestad, A. and Biessen, E.A. and Aukrust, P.
Cardiovascular Research 102 (1): 148-156. 1 April 2014

Cell Reports

Lymphocyte access to lymphoma is impaired by high endothelial venule regression.
Menzel, L. and Zschummel, M. and Crowley, T. and Franke, V. and Grau, M. and Ulbricht, C. and Hauser, A. and Siffrin, V. and Bajénoff, M. and Acton, S.E. and Akalin, A. and Lenz, G. and Willimsky, G. and Höpken, U.E. and Rehm, A.
Cell Reports 37 (4): 109878. 26 October 2021

EMBO Journal

Transcriptional repression of NFKBIA triggers constitutive IKK- and proteasome-independent p65/RelA activation in senescence.
Kolesnichenko, M. and Mikuda, N. and Höpken, U.E. and Kärgel, E. and Uyar, B. and Tufan, A.B. and Milanovic, M. and Sun, W. and Krahn, I. and Schleich, K. and von Hoff, L. and Hinz, M. and Willenbrock, M. and Jungmann, S. and Akalin, A. and Lee, S. and Schmidt-Ullrich, R. and Schmitt, C.A. and Scheidereit, C.
EMBO Journal 40 (6): e104296. 15 March 2021

The transcriptional coactivator Bob1 promotes the development of follicular T helper cells via Bcl6.
Stauss, D. and Brunner, C. and Berberich-Siebelt, F. and Höpken, U.E. and Lipp, M. and Müller, G.
EMBO Journal 35 (8): 881-898. 15 April 2016

European Journal of Clinical Investigation

Effects of anti-C5a monoclonal antibodies on oxygen use in a porcine model of severe sepsis.
Mohr, M. and Höpken, U. and Oppermann, M. and Mathes, C. and Goldmann, K. and Siever, S. and Goetze, O. and Burchardi, H.
European Journal of Clinical Investigation 28 (3): 227-234. March 1998

European Journal of Immunology

Antigen receptor-engineered Tregs inhibit CNS autoimmunity in cell therapy using non-redundant immune mechanisms in mice.
Pohar, J. and O'Connor, R. and Manfroi, B. and Behi, M.E. and Jouneau, L. and Boudinot, P. and Bunse, M. and Uckert, W. and Luka, M. and Ménager, M. and Liblau, R. and Anderton, S.M. and Fillatreau, S.
European Journal of Immunology 52 (8): 1335-1349. August 2022

B-cell-intrinsic STAT6 signaling controls germinal center formation.
Turqueti-Neves, A. and Otte, M. and da Costa, O.P. and Höpken, U.E. and Lipp, M. and Buch, T. and Voehringer, D.
European Journal of Immunology 44 (7): 2130-2138. July 2014

Distinctive role of CCR7 in migration and functional activity of naive- and effector/memory-like Treg subsets.
Menning, A. and Höpken, U.E. and Siegmund, K. and Lipp, M. and Hamann, A. and Huehn, J.
European Journal of Immunology 37 (6): 1575-1583. June 2007

Salmonella typhimurium infection triggers dendritic cells and macrophages to adopt distinct migration patterns in vivo.
Zhao, C. and Wood, M.W. and Galyov, E.E. and Höpken, U.E. and Lipp, M. and Bodmer, H.C. and Tough, D.F. and Carter, R.W.
European Journal of Immunology 36 (11): 2939-2950. November 2006

The ratio between dendritic cells and T cells determines the outcome of their encounter: Proliferation versus deletion.
Höpken, U.E. and Lehmann, I. and Droese, J. and Lipp, M. and Schueler, T. and Rehm, A.
European Journal of Immunology 35 (10): 2851-2863. 23 September 2005

The chemokine receptor CCR7 controls lymph node-dependent cytotoxic T cell priming in alloimmune responses.
Höpken, U.E. and Droese, J. and Li, J.P. and Joergensen, J. and Breitfeld, D. and Zerwes, H.G. and Lipp, M.
European Journal of Immunology 34 (2): 461-470. 1 January 2004

Inhibition of interleukin-6 synthesis in an animal model of septic shock by anti-C5a monoclonal antibodies.
Höpken, U. and Mohr, M. and Strueber, A. and Montz, H. and Burchardi, H. and Götze, O. and Oppermann, M.
European Journal of Immunology 26 (5): 1103-1109. May 1996

FASEB Journal

Dysregulated development of IL-17-and IL-21-expressing follicular helper T cells and increased germinal center formation in the absence of RORγt.
Wichner, K. and Stauss, D. and Kampfrath, B. and Krüger, K. and Müller, G. and Rehm, A. and Lipp, M. and Höpken, U.E.
FASEB Journal 30 (2): 761-774. February 2016

Frontiers in Immunology

Angiogenesis in lymph nodes is a critical regulator of immune response and lymphoma growth.
Menzel, L. and Höpken, U.E. and Rehm, A.
Frontiers in Immunology 11 : 591741. 3 December 2020

Immunity

A local subset of mesenchymal cells expressing the transcription factor Osr1 orchestrates lymph node initiation.
Vallecillo-García, P. and Orgeur, M. and Comai, G. and Poehle-Kronnawitter, S. and Fischer, C. and Gloger, M. and Dumas, C.E. and Giesecke-Thiel, C. and Sauer, S. and Tajbakhsh, S. and Höpken, U.E. and Stricker, S.
Immunity 56 (6): 1204-1219. 13 June 2023

The sorting receptor sortilin exhibits a dual function in exocytic trafficking of interferon-γ and granzyme A in T cells.
Herda, S. and Raczkowski, F. and Mittruecker, H.W. and Willimsky, G. and Gerlach, K. and Kuehl, A.A. and Breiderhoff, T. and Willnow, T.E. and Doerken, B. and Höpken, U.E. and Rehm, A.
Immunity 37 (5): 854-866. 16 November 2012

All roads lead to rome: triggering dendritic cell migration.
Höpken, U.E. and Lipp, M.
Immunity 20 (3): 244-246. March 2004

Role for CCR7 Ligands in the emigration of newly generated T lymphocytes from the neonatal thymus.
Ueno, T. and Hara, K. and Willis, M.S. and Malin, M.A. and Höpken, U.E. and Gray, D.H.D. and Matsushima, K. and Lipp, M. and Springer, T.A. and Boyd, R.L. and Yoshie, O. and Takahama, Y.
Immunity 16 (2): 205-218. 1 January 2002

Immunological Reviews

The impact of CCR7 and CXCR5 on lymphoid organ development and systemic immunity.
Müller, G. and Höpken, U.E. and Lipp, M.
Immunological Reviews 195 (1): 117-135. October 2003

Immunopharmacology

Assessment of complement activation in vivo.
Oppermann, M. and Höpken, U. and Götze, O.
Immunopharmacology 24 (2): 119-34. September 1992

International Journal of Cancer

Identification of a chemokine receptor profile characteristic for mediastinal large B-cell lymphoma.
Rehm, A. and Anagnostopoulos, I. and Gerlach, K. and Broemer, M. and Scheidereit, C. and Joehrens, K. and Huebler, M. and Hetzer, R. and Stein, H. and Lipp, M. and Doerken, B. and Höpken, U.E.
International Journal of Cancer 125 (10): 2367-2374. 15 November 2009

International Journal of Molecular Sciences

In vitro functionality and endurance of GMP-compliant point-of-care BCMA.CAR-T cells at different timepoints of cryopreservation.
Jiang, G. and Neuber, B. and Hückelhoven-Krauss, A. and Höpken, U. and Ding, Y. and Sedloev, D. and Wang, L. and Reichman, A. and Eberhardt, F. and Wermke, M. and Rehm, A. and Müller-Tidow, C. and Schmitt, A. and Schmitt, M.
International Journal of Molecular Sciences 25 (3): 1394. 23 January 2024

Comparison of FACS and PCR for detection of BCMA-CAR-T cells.
Reichman, A. and Kunz, A. and Joedicke, J.J. and Höpken, U.E. and Keib, A. and Neuber, B. and Sedloev, D. and Wang, L. and Jiang, G. and Hückelhoven-Krauss, A. and Eberhardt, F. and Müller-Tidow, C. and Wermke, M. and Rehm, A. and Schmitt, M. and Schmitt, A.
International Journal of Molecular Sciences 23 (2): 903. 14 January 2022

JCI Insight

EBAG9 controls CD8(+) T cell memory formation responding to tumor challenge in mice.
Rehm, A. and Wirges, A. and Hoser, D. and Fischer, C. and Herda, S. and Gerlach, K. and Sauer, S. and Willimsky, G. and Hoepken, U.E.
JCI Insight 7 (11): e155534. 8 June 2022

Journal of Autoimmunity

Transition from an autoimmune-prone state to fatal autoimmune disease in CCR7 and RORγt double-deficient mice is dependent on gut microbiota.
Wichner, K. and Fischer, A. and Winter, S. and Tetzlaff, S. and Heimesaat, M.M. and Bereswill, S. and Rehm, A. and Lipp, M. and Höpken, U.E.
Journal of Autoimmunity 47 : 58-72. December 2013

Journal of Biological Chemistry

Surface expression and endocytosis of the human cytomegalovirus-encoded chemokine receptor US28 is regulated by agonist-independent phosphorylation.
Mokros, T. and Rehm, A. and Droese, J. and Oppermann, M. and Lipp, M. and Höpken, U.E.
Journal of Biological Chemistry 277 (47): 45122-45128. 1 January 2002

Journal of Clinical Investigation

The tumor-associated antigen EBAG9 negatively regulates the cytolytic capacity of mouse CD8+ T cells.
Rueder, C. and Höpken, U.E. and Wolf, J. and Mittruecker, H.W. and Engels, B. and Erdmann, B. and Wollenzin, S. and Uckert, W. and Dörken, B. and Rehm, A.
Journal of Clinical Investigation 119 (8): 2184-2203. August 2009

Journal of Experimental Medicine

Differential requirements for the chemokine receptor CCR7 in T cell activation during Listeria monocytogenes infection.
Kursar, M. and Höpken, U.E. and Koch, M. and Koehler, A. and Lipp, M. and Kaufmann, S.H. and Mittrücker, H.W.
Journal of Experimental Medicine 201 (9): 1447-1457. 2 May 2005

Regulation of dendritic cell migration to the draining lymph node: Impact on T lymphocyte traffic and priming.
Martin-Fontecha, A. and Sebastiani, S. and Höpken, U.E. and Uguccioni, M. and Lipp, M. and Lanzavecchia, A. and Sallusto, F.
Journal of Experimental Medicine 198 (4): 615-621. 18 August 2003

Impaired inflammatory responses in the reverse arthus reaction through genetic deletion of the C5a receptor.
Höpken, U.E. and Lu, B. and Gerard, N.P. and Gerard, C.
Journal of Experimental Medicine 186 (5): 749-756. 29 August 1997

Journal of Immunology

In vivo differentiated cytokine-producing CD4+ T cells express functional CCR7.
Debes, G.F. and Höpken, U.E. and Hamann, A.
Journal of Immunology 168 (11): 5441-5447. 1 June 2002

Alternate splicing of mouse fusin/CXC chemokine receptor-4: stromal cell-derived factor-1α is a ligand for both CXC chemokine receptor-4 isoforms.
Heesen, M. and Berman, M.A. and Höpken, U.E. and Gerard, N.P. and Dorf, M.E.
Journal of Immunology 158 (8): 3561-3564. 15 April 1997

Journal of Infectious Diseases

Mycobacterium tuberculosis triggers formation of lymphoid structure in murine lungs.
Kahnert, A. and Höpken, U.E. and Stein, M. and Bandermann, S. and Lipp, M. and Kaufmann, S.H.
Journal of Infectious Diseases 195 (1): 46-54. 1 January 2007

Journal of Leukocyte Biology

CCR7 regulates lymphocyte egress and recirculation through body cavities.
Höpken, U.E. and Winter, S. and Achtman, A.H. and Krueger, K. and Lipp, M.
Journal of Leukocyte Biology 87 (4): 671-682. April 2010

CCR7-deficient mice develop atypically persistent germinal centers in response to thymus-independent type 2 antigens.
Achtman, A.H. and Höpken, U.E. and Bernert, C. and Lipp, M.
Journal of Leukocyte Biology 85 (3): 409-417. March 2009

Distinct and overlapping roles of CXCR5 and CCR7 in B-1 cell homing and early immunity against bacterial pathogens.
Höpken, U.E. and Achtman, A.H. and Krueger, K. and Lipp, M.
Journal of Leukocyte Biology 76 (3): 709-718. September 2004

Systemic immunoregulatory and pathogenic functions of homeostatic chemokine receptors.
Müller, G. and Höpken, U.E. and Stein, H. and Lipp, M.
Journal of Leukocyte Biology 72 (1): 1-8. July 2002

Journal of Molecular Medicine

Homeostatic chemokines guide lymphoma cells to tumor growth-promoting niches within secondary lymphoid organs.
Höpken, U.E. and Rehm, A.
Journal of Molecular Medicine 90 (11): 1237-1245. November 2012

The chemokine receptor CXCR5 is pivotal for ectopic mucosa-associated lymphoid tissue neogenesis in chronic Helicobacter pylori-induced inflammation.
Winter, S. and Loddenkemper, C. and Aebischer, A. and Raebel, K. and Hoffmann, K. and Meyer, T.F. and Lipp, M. and Höpken, U.E.
Journal of Molecular Medicine 88 (11): 1169-1180. November 2010

Brain antigens in functionally distinct antigen-presenting cell populations in cervical lymph nodes in MS and EAE.
van Zwam, M. and Huizinga, R. and Melief, M.J. and Wierenga-Wolf, A.F. and van Meurs, M. and Voerman, J.S. and Biber, K.P. and Boddeke, H.W. and Höpken, U.E. and Meisel, C. and Meisel, A. and Bechmann, I. and Hintzen, R.Q. and 't Hart, B.A. and Amor, S. and Laman, J.D. and Boven, L.A.
Journal of Molecular Medicine 87 (3): 273-286. March 2009

Journal of Pathology

CXCR4 mediates leukemic cell migration and survival in the testicular microenvironment.
Skroblyn, T. and Joedicke, J.J. and Pfau, M. and Krüger, K. and Bourquin, J.P. and Izraeli, S. and Eckert, C. and Höpken, U.E.
Journal of Pathology 258 (1): 12-25. September 2022

Deficiency in IκBα in the intestinal epithelium leads to spontaneous inflammation and mediates apoptosis in the gut.
Mikuda, N. and Schmidt-Ullrich, R. and Kärgel, E. and Golusda, L. and Wolf, J. and Höpken, U.E. and Scheidereit, C. and Kühl, A.A. and Kolesnichenko, M.
Journal of Pathology 251 (2): 160-174. June 2020

Journal of Virology

Human cytomegalovirus gene products US2 and US11 differ in their ability to attack major histocompatibility class I heavy chains in dendritic cells.
Rehm, A. and Engelsberg, A. and Tortorella, D. and Körner, I.J. and Lehmann, I. and Ploegh, H.L. and Höpken, U.E.
Journal of Virology 76 (10): 5043-5050. May 2002

Methods in Molecular Biology

Generation of redirected engineered human chimeric antigen receptor (CAR) T cells.
Bunse, M. and Höpken, U.E.
Methods in Molecular Biology 2521 (3): 67-83. 23 June 2022

Molecular Biology and Evolution

A novel gene controls a new structure: piggyBac transposable element-derived 1, unique to mammals, controls mammal-specific neuronal paraspeckles.
Raskó, T. and Pande, A. and Radscheit, K. and Zink, A. and Singh, M. and Sommer, C. and Wachtl, G. and Kolacsek, O. and Inak, G. and Szvetnik, A. and Petrakis, S. and Bunse, M. and Bansal, V. and Selbach, M. and Orbán, T.I. and Prigione, A. and Hurst, L.D. and Izsvák, Z.
Molecular Biology and Evolution 39 (10): msac175. October 2022

Molecular Biology of B Cells (Second Edition)

B cell localization and migration in health and disease.
Hauser, A.E. and Höpken, U.E.
In: Molecular Biology of B Cells. Academic Press, 187-214. ISBN 978-0-12-397933-9 2015

Molecular Oncology

Potent anti-tumor response by targeting B cell maturation antigen (BCMA) in a mouse model of multiple myeloma.
Oden, F. and Marino, S.F. and Brand, J. and Scheu, S. and Kriegel, C. and Olal, D. and Takvorian, A. and Westermann, J. and Yilmaz, B. and Hinz, M. and Daumke, O. and Höpken, U.E. and Müller, G. and Lipp, M.
Molecular Oncology 9 (7): 1348-1358. August 2015

Molecular Therapy

EBAG9-silencing exerts an immune checkpoint function without aggravating adverse effects.
Wirges, A. and Bunse, M. and Joedicke, J.J. and Blanc, E. and Gudipati, V. and Moles, M.W. and Shiku, H. and Beule, D. and Huppa, J.B. and Höpken, U.E. and Rehm, A.
Molecular Therapy 30 (11): 3358-3378. 2 November 2022

CAR T cells with enhanced sensitivity to B cell maturation antigen for the targeting of B cell non-Hodgkin's lymphoma and multiple myeloma.
Bluhm, J. and Kieback, E. and Marino, S.F. and Oden, F. and Westermann, J. and Chmielewski, M. and Abken, H. and Uckert, W. and Höpken, U.E. and Rehm, A.
Molecular Therapy 26 (8): 1906-1920. 1 August 2018

Molecular Therapy - Methods and Clinical Development

Pharmacological interventions enhance virus-free generation of TRAC-replaced CAR T cells.
Kath, J. and Du, W. and Pruene, A. and Braun, T. and Thommandru, B. and Turk, R. and Sturgeon, M.L. and Kurgan, G.L. and Amini, L. and Stein, M. and Zittel, T. and Martini, S. and Ostendorf, L. and Wilhelm, A. and Akyüz, L. and Rehm, A. and Hoepken, U.E. and Pruß, A. and Künkele, A. and Jacobi, A.M. and Volk, H.D. and Schmueck-Henneresse, M. and Stripecke, R. and Reinke, P. and Wagner, D.L.
Molecular Therapy - Methods and Clinical Development 25 : 311-330. 9 June 2022

Accelerating clinical scale production of BCMA CAR T cells with defined maturation stages.
Joedicke, J.J. and Großkinsky, U. and Gerlach, K. and Künkele, A. and Höpken, U.E. and Rehm, A.
Molecular Therapy - Methods and Clinical Development 24 : 181-198. 10 March 2022

Mucosal Immunology

CCR7 deficiency causes diarrhea associated with altered ion transport in colonocytes in the absence of overt colitis.
Schumann, M. and Winter, S. and Wichner, K. and May, C. and Kuehl, A.A. and Batra, A. and Siegmund, B. and Zeitz, M. and Schulzke, J.D. and Lipp, M. and Höpken, U.E.
Mucosal Immunology 5 (4): 377-387. July 2012

Nature

The C5a chemoattractant receptor mediates mucosal defence to infection.
Höpken, U.E. and Lu, B. and Gerard, N.P. and Gerard, C.
Nature 383 (6595): 86-89. 5 September 1996

Nature Communications

Quadruple gene-engineered natural killer cells enable multi-antigen targeting for durable antitumor activity against multiple myeloma.
Cichocki, F. and Bjordahl, R. and Goodridge, J.P. and Mahmood, S. and Gaidarova, S. and Abujarour, R. and Davis, Z.B. and Merino, A. and Tuininga, K. and Wang, H. and Kumar, A. and Groff, B. and Witty, A. and Bonello, G. and Huffman, J. and Dailey, T. and Lee, T.T. and Malmberg, K.J. and Walcheck, B. and Höpken, U. and Rehm, A. and Valamehr, B. and Miller, J.S.
Nature Communications 13 (1): 7341. 29 November 2022

CXCR5 CAR-T cells simultaneously target B cell non-Hodgkin's lymphoma and tumor-supportive follicular T helper cells.
Bunse, M. and Pfeilschifter, J. and Bluhm, J. and Zschummel, M. and Joedicke, J.J. and Wirges, A. and Stark, H. and Kretschmer, V. and Chmielewski, M. and Uckert, W. and Abken, H. and Westermann, J. and Rehm, A. and Höpken, U.E.
Nature Communications 12 (1): 240. 11 January 2021

Dendritic cell-mediated survival signals in Eμ-Myc B-cell lymphoma depend on the transcription factor C/EBPβ.
Rehm, A. and Gätjen, M. and Gerlach, K. and Scholz, F. and Mensen, A. and Gloger, M. and Heinig, K. and Lamprecht, B. and Mathas, S. and Bégay, V. and Leutz, A. and Lipp, M. and Dörken, B. and Höpken, U.E.
Nature Communications 5 : 5057. 30 September 2014

Nature Immunology

Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation.
van de Pavert, S.A. and Olivier, B.J. and Goverse, G. and Vondenhoff, M.F. and Greuter, M. and Beke, P. and Kusser, K. and Höpken, U.E. and Lipp, M. and Niederreither, K. and Blomhoff, R. and Sitnik, K. and Agace, W.W. and Randall, T.D. and de Jonge, W.J. and Mebius, R.E.
Nature Immunology 10 (11): 1193-1199. November 2009

Neuroscience

Expression of C5a receptor in mouse brain: role in signal transduction and neurodegeneration.
Osaka, H. and McGinty, A. and Höpken, U.E. and Lu, B. and Gerard, C. and Pasinetti, G.M.
Neuroscience 88 (4): 1073-1082. February 1999

OncoImmunology

The splenic marginal zone shapes the phenotype of leukemia B cells and facilitates their niche-specific retention and survival.
Stache, V. and Verlaat, L. and Gätjen, M. and Heinig, K. and Westermann, J. and Rehm, A. and Höpken, U.E.
OncoImmunology 6 (6): e1323155. 6 June 2017

PLoS ONE

Loss of Gadkin affects dendritic cell migration in vitro.
Schachtner, H. and Weimershaus, M. and Stache, V. and Plewa, N. and Legler, D.F. and Höpken, U.E. and Maritzen, T.
PLoS ONE 10 (12): e0143883. 1 December 2015

Proceedings of the National Academy of Sciences of the United States of America

The transcription factor C/EBPβ orchestrates dendritic cell maturation and functionality under homeostatic and malignant conditions.
Scholz, F. and Grau, M. and Menzel, L. and Graband, A. and Zapukhlyak, M. and Leutz, A. and Janz, M. and Lenz, G. and Rehm, A. and Höpken, U.E.
Proceedings of the National Academy of Sciences of the United States of America 117 (42): 26328-26339. 20 October 2020

STAR Protocols

Analyses of murine lymph node endothelial cell subsets using single-cell RNA sequencing and spectral flow cytometry.
Menzel, L. and Zschummel, M. and Rehm, A.
STAR Protocols 3 (2): 101267. 17 June 2022

Science

Neurogenic amplification of immune complex inflammation.
Bozic, C.R. and Lu, B. and Höpken, U.E. and Gerard, C. and Gerard, N.P.
Science 273 (5282): 1722-1725. 20 September 1996

Science Immunology

C/EBPβ regulates lipid metabolism and Pparg isoform 2 expression in alveolar macrophages.
Dörr, D. and Obermayer, B. and Weiner, J.M. and Zimmermann, K. and Anania, C. and Wagner, L.K. and Lyras, E.M. and Sapozhnikova, V. and Lara-Astiaso, D. and Prósper, F. and Lang, R. and Lupiáñez, D.G. and Beule, D. and Höpken, U.E. and Leutz, A. and Mildner, A.
Science Immunology 7 (75): eabj0140. September 2022

Thrombosis and Haemostasis

Interruption of the CXCL13/CXCR5 chemokine axis enhances plasma IgM levels and attenuates atherosclerosis development.
van der Vorst, E.P.C. and Daissormont, I. and Aslani, M. and Seijkens, T. and Wijnands, E. and Lutgens, E. and Duchene, J. and Santovito, D. and Döring, Y. and Halvorsen, B. and Aukrust, P. and Weber, C. and Höpken, U.E. and Biessen, E.A.L.
Thrombosis and Haemostasis 120 (2): 344-347. February 2020

Trends in Cancer

Targeting the tumor microenvironment of leukemia and lymphoma.
Höpken, U.E. and Rehm, A.
Trends in Cancer 5 (6): 351-364. June 2019

bioRxiv

Fast, efficient and virus-free generation of TRAC-replaced CAR T cells.
Kath, J. and Du, W. and Thommandru, B. and Turk, R. and Amini, L. and Stein, M. and Zittel, T. and Martini, S. and Ostendorf, L. and Wilhelm, A. and Akyuez, L. and Rehm, A. and Hoepken, U.E. and Pruss, A. and Kuenkele, A. and Jacobi, A.M. and Volk, H.D. and Schmueck-Henneresse, M. and Reinke, P. and Wagner, D.L.
bioRxiv : 2021.02.14.431017. 14 February 2021

Human endogenous retrovirus K Rec forms a regulatory loop with MITF that opposes the progression of melanoma to an invasive stage.
Singh, M. and Cai, H. and Bunse, M. and Feschotte, C. and Izsvak, Z.
bioRxiv : 2020.05.27.120170. 2 June 2020

A novel IKK- and proteasome-independent mechanism of RelA activation triggers senescence associated secretome via transcriptional repression of NFKBIA.
Kolesnichenko, M. and Mikuda, N. and Höpken, U.E. and Milanovic, M. and Tufan, A.B. and Uyar, B. and Sun, W. and Schleich, K. and von Hoff, L. and Willenbrock, M. and Krahn, I. and Jungmann, S. and Hinz, M. and Akalin, A. and Lee, S. and Schmidt-Ullrich, R. and Schmitt, C.A. and Scheidereit, C.
bioRxiv : 2019.12.19.882225. 20 December 2019

This list was generated on Thu Mar 28 02:23:21 2024 CET.
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