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Abnormal biomarkers predict complex FAS or FADD defects missed by exome sequencing.
Rensing-Ehl, A. and Lorenz, M.R. and Führer, M. and Willenbacher, W. and Willenbacher, E. and Sopper, S. and Abinun, M. and Maccari, M.E. and König, C. and Haegele, P. and Fuchs, S. and Castro, C. and Kury, P. and Pelle, O. and Klemann, C. and Heeg, M. and Thalhammer, J. and Wegehaupt, O. and Fischer, M. and Goldacker, S. and Schulte, B. and Biskup, S. and Chatelain, P. and Schuster, V. and Warnatz, K. and Grimbacher, B. and Meinhardt, A. and Holzinger, D. and Oommen, P.T. and Hinze, T. and Hebart, H. and Seeger, K. and Lehmberg, K. and Leahy, T.R. and Claviez, A. and Vieth, S. and Schilling, F.H. and Fuchs, I. and Groß, M. and Rieux-Laucat, F. and Magerus, A. and Speckmann, C. and Schwarz, K. and Ehl, S.
Journal of Allergy and Clinical Immunology 153 (1): 297-308. January 2024

Defining the landscape of circular RNAs in neuroblastoma unveils a global suppressive function of MYCN.
Fuchs, S. and Danßmann, C. and Klironomos, F. and Winkler, A. and Fallmann, J. and Kruetzfeldt, L.M. and Szymansky, A. and Naderi, J. and Bernhart, S.H. and Grunewald, L. and Helmsauer, K. and Rodriguez-Fos, E. and Kirchner, M. and Mertins, P. and Astrahantseff, K. and Suenkel, C. and Toedling, J. and Meggetto, F. and Remke, M. and Stadler, P.F. and Hundsdoerfer, P. and Deubzer, H.E. and Künkele, A. and Lang, P. and Fuchs, J. and Henssen, A.G. and Eggert, A. and Rajewsky, N. and Hertwig, F. and Schulte, J.H.
Nature Communications 14 (1): 3936. 4 July 2023

Optimising urinary catecholamine metabolite diagnostics for neuroblastoma.
Matser, Y.A.H. and Verly, I.R.N. and van der Ham, M. and de Sain‐van der Velden, M.G.M. and Verhoeven‐Duif, N.M. and Ash, S. and Cangemi, G. and Barco, S. and Popovic, M.B. and van Kuilenburg, A.B.P. and Tytgat, G.A.M.
Pediatric Blood and Cancer 70 (6): e30289. June 2023

Parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells.
Chamorro González, R. and Conrad, T. and Stöber, M.C. and Xu, R. and Giurgiu, M. and Rodriguez-Fos, E. and Kasack, K. and Brückner, L. and van Leen, E. and Helmsauer, K. and Dorado Garcia, H. and Stefanova, M.E. and Hung, K.L. and Bei, Y. and Schmelz, K. and Lodrini, M. and Mundlos, S. and Chang, H.Y. and Deubzer, H.E. and Sauer, S. and Eggert, A. and Schulte, J.H. and Schwarz, R.F. and Haase, K. and Koche, R.P. and Henssen, A.G.
Nature Genetics 55 (5): 880-890. May 2023

Treatment of infants and children with SARS-CoV-2 monoclonal antibodies: a European case series.
Rau, C. and Auer-Hackenberg, L. and Deubzer, H.E. and Schwabel, E. and Jaros, M. and Diederichs, A. and Lehrnbecher, T. and Holm, M. and von Linstow, M.L. and Martin, L. and Dinges, S.S. and Rothensteiner, M. and Siepermann, M. and Strenger, V. and von Both, U. and Teig, N. and Brinkmann, F. and Leeb, F. and Zeitlinger, M. and Kobbe, R. and Götzinger, F.
Pediatric Infectious Disease Journal 42 (2): 125-129. February 2023

Efficacy and feasibility of proton beam therapy in relapsed high-risk neuroblastoma-experiences from the prospective KiProReg registry.
Jazmati, D. and Hero, B. and Thole-Kliesch, T.M. and Merta, J. and Deubzer, H.E. and Bäumer, C. and Heinzelmann, F. and Schleithoff, S.S. and Koerber, F. and Eggert, A. and Schwarz, R. and Simon, T. and Timmermann, B.
Current Oncology 29 (11): 8222-8234. November 2022

Incidence of subsequent malignancies after total body irradiation-based allogeneic HSCT in children with ALL - long-term follow-up from the prospective ALL-SCT 2003 trial.
Eichinger, A. and Poetschger, U. and Glogova, E. and Bader, P. and Basu, O. and Beier, R. and Burkhardt, B. and Classen, C.F. and Claviez, A. and Corbacioglu, S. and Deubzer, H.E. and Greil, J. and Gruhn, B. and Güngör, T. and Kafa, K. and Kühl, J.S. and Lang, P. and Lange, B.S. and Meisel, R. and Müller, I. and Sauer, M.G. and Schlegel, P.G. and Schulz, A. and Stachel, D. and Strahm, B. and Wawer, A. and Peters, C. and Albert, M.H.
Leukemia 36 (11): 2567-2576. November 2022

Evidence of neural crest cell origin of a DICER1 mutant CNS sarcoma in a child with DICER1 syndrome and NRAS-mutant neurocutaneous melanosis.
Schweizer, L. and Hartmann, W. and Koch, A. and Nunninger, M. and Thomale, U.W. and Pennacchietti, V. and Tietze, A. and Horn, D. and Pajtler, K.W. and Hirsch, S. and Wieland, I. and Deubzer, H. and Rossi, R. and Hernáiz Driever, P. and von Hoff, K. and von Zezschwitz, B.
Neuropathology and Applied Neurobiology 48 (6): e12830. October 2022

Mutations in ALK signaling pathways conferring resistance to ALK inhibitor treatment lead to collateral vulnerabilities in neuroblastoma cells.
Berlak, M. and Tucker, E. and Dorel, M. and Winkler, A. and McGearey, A. and Rodriguez-Fos, E. and da Costa, B.M. and Barker, K. and Fyle, E. and Calton, E. and Eising, S. and Ober, K. and Hughes, D. and Koutroumanidou, E. and Carter, P. and Stankunaite, R. and Proszek, P. and Jain, N. and Rosswog, C. and Dorado-Garcia, H. and Molenaar, J.J. and Hubank, M. and Barone, G. and Anderson, J. and Lang, P. and Deubzer, H.E. and Künkele, A. and Fischer, M. and Eggert, A. and Kloft, C. and Henssen, A.G. and Boettcher, M. and Hertwig, F. and Blüthgen, N. and Chesler, L. and Schulte, J.H.
Molecular Cancer 21 (1): 126. 10 June 2022

Genomic evolution and personalized therapy of an infantile fibrosarcoma harboring an NTRK oncogenic fusion.
Thorwarth, A. and Haase, K. and Röefzaad, C. and Pajtler, K.W. and Schramm, K. and Hauptmann, K. and Behnke, A. and Vokuhl, C. and Elgeti, T. and Gratopp, A. and Schulte, J.H. and Scheer, M. and Hernáiz Driever, P. and Nysom, K. and Eggert, A. and Henssen, A.G. and Deubzer, H.E.
JCO Precision Oncology 6 : e2100283. 25 May 2022

Targeted analysis of cell-free circulating tumor DNA is suitable for early relapse and actionable target detection in patients with neuroblastoma.
Lodrini, M. and Graef, J. and Thole-Kliesch, T.M. and Astrahantseff, K. and Sprüssel, A. and Grimaldi, M. and Peitz, C. and Linke, R.B. and Hollander, J.F. and Lankes, E. and Künkele, A. and Oevermann, L. and Schwabe, G. and Fuchs, J. and Szymansky, A. and Schulte, J.H. and Hundsdoerfer, P. and Eckert, C. and Amthauer, H. and Eggert, A. and Deubzer, H.E.
Clinical Cancer Research 28 (9): 1809-1820. 1 May 2022

Circulating cell-free DNA assessment in biofluids from children with neuroblastoma demonstrates feasibility and potential for minimally invasive molecular diagnostics.
Lodrini, M. and Wünschel, J. and Thole-Kliesch, T.M. and Grimaldi, M. and Sprüssel, A. and Linke, R.B. and Hollander, J.F. and Tiburtius, D. and Künkele, A. and Schulte, J.H. and Lankes, E. and Elgeti, T. and Hundsdörfer, P. and Astrahantseff, K. and Simon, T. and Eggert, A. and Deubzer, H.E.
Cancers 14 (9): 2080. 21 April 2022

Hemostatic management in an infant with neuroblastoma and severe hemophilia B with extended half-life recombinant factor IX fusion protein.
Cuntz, F. and Deubzer, H.E. and Schulte, J.H. and Nimtz-Talaska, A. and Eggert, A. and Holzhauer, S.
Journal of Pediatric Hematology Oncology 44 (1): e246-e249. 1 January 2022

Bioprinted cancer model of neuroblastoma in a renal microenvironment as an efficiently applicable drug testing platform.
Wu, D. and Berg, J. and Arlt, B. and Röhrs, V. and Al-Zeer, M.A. and Deubzer, H.E. and Kurreck, J.
International Journal of Molecular Sciences 23 (1): 122. 23 December 2021

Neuroblastoma risk assessment and treatment stratification with hybrid capture-based panel sequencing.
Szymansky, A. and Kruetzfeldt, L.M. and Heukamp, L.C. and Hertwig, F. and Theissen, J. and Deubzer, H.E. and Willing, E.M. and Menon, R. and Fuchs, S. and Thole, T. and Schulte, S. and Schmelz, K. and Künkele, A. and Lang, P. and Fuchs, J. and Eggert, A. and Eckert, C. and Fischer, M. and Henssen, A.G. and Rodriguez-Fos, E. and Schulte, J.H.
Journal of Personalized Medicine 11 (8): 691. August 2021

Inhibiting PHGDH with NCT-503 reroutes glucose-derived carbons into the TCA cycle, independently of its on-target effect.
Arlt, B. and Mastrobuoni, G. and Wuenschel, J. and Astrahantseff, K. and Eggert, A. and Kempa, S. and Deubzer, H.E.
Journal of Enzyme Inhibition and Medicinal Chemistry 36 (1): 1282-1289. 30 June 2021

A reproducible bioprinted 3D tumor model serves as a preselection tool for CAR T cell therapy optimization.
Grunewald, L. and Lam, T. and Andersch, L. and Klaus, A. and Schwiebert, S. and Winkler, A. and Gauert, A. and Heeren-Hagemann, A.I. and Astrahantseff, K. and Klironomos, F. and Thomas, A. and Deubzer, H.E. and Henssen, A.G. and Eggert, A. and Schulte, J.H. and Anders, K. and Kloke, L. and Künkele, A.
Frontiers in Immunology 12 : 689697. 29 June 2021

Germline mutations including the rare pathogenic variant c.3206delC in the ATM gene cause ataxia teleangiectasia-associated primary central nervous system lymphoma.
Dörr, J.R. and Thorwarth, A. and Mizia-Malarz, A. and Radke, J. and Tietze, A. and Hernáiz-Driever, P. and Horn, D. and Gratopp, A. and Eggert, A. and Deubzer, H.E.
Children 8 (6): 469. June 2021

„Liquid biopsies“ als neue Diagnostikplattform in der pädiatrischen Onkologie [Liquid biopsies as a new diagnostic platform in pediatric oncology].
Deubzer, H.E. and Eggert, A. and Pajtler, K. W.
Onkologe 27 (5): 458-463. May 2021

Inhibiting phosphoglycerate dehydrogenase counteracts chemotherapeutic efficacy against MYCN-amplified neuroblastoma.
Arlt, B. and Zasada, C. and Baum, K. and Wuenschel, J. and Mastrobuoni, G. and Lodrini, M. and Astrahantseff, K. and Winkler, A. and Schulte, J.H. and Finkler, S. and Forbes, M. and Hundsdoerfer, P. and Guergen, D. and Hoffmann, J. and Wolf, J. and Eggert, A. and Kempa, S. and Deubzer, H.E.
International Journal of Cancer 148 (5): 1219-1232. 1 March 2021

Clinical presentation and management of a dinutuximab beta extravasation in a patient with neuroblastoma.
Launspach, M. and Seif, M. and Thole, TM. and Jesse, P. and Schulz, J. and Schulte, J.H. and Bischoff, S. and Eggert, A. and Deubzer, H.E.
Children 8 (2): 91. 29 January 2021

Multiplexed quantification of four neuroblastoma DNA targets in a single droplet digital PCR reaction.
Peitz, C. and Sprüssel, A. and Linke, R.B. and Astrahantseff, K. and Grimaldi, M. and Schmelz, K. and Toedling, J. and Schulte, J.H. and Fischer, M. and Messerschmidt, C. and Beule, D. and Keilholz, U. and Eggert, A. and Deubzer, H.E. and Lodrini, M.
Journal of Molecular Diagnostics 22 (11): 1309-1323. November 2020

Sinusoidal obstruction syndrome following myeloablative therapy and tranexamic acid treatment for hemorrhage in two patients with neuroblastoma.
Zirngibl, F. and Flemmig, C. and Lang, P. and Künkele, A. and Eggert, A. and Schulte, J.H. and Deubzer, H.E.
Children 7 (11): 198. November 2020

Central memory phenotype drives success of checkpoint inhibition in combination with CAR T cells.
Toews, K. and Grunewald, L. and Schwiebert, S. and Klaus, A. and Winkler, A. and Ali, S. and Zirngibl, F. and Astrahantseff, K. and Wagner, D.L. and Henssen, A.G. and Deubzer, H.E. and Schulte, J.H. and Ochsenreither, S. and Eggert, A. and Künkele, A.
Molecular Carcinogenesis 59 (7): 724-273. July 2020

Tumor-derived extracellular vesicles impair CD171-specific CD4(+) CAR T cell efficacy.
Ali, S. and Toews, K. and Schwiebert, S. and Klaus, A. and Winkler, A. and Grunewald, L. and Oevermann, L. and Deubzer, H.E. and Tüns, A. and Jensen, M.C. and Henssen, A.G. and Eggert, A. and Schulte, J.H. and Schwich, E. and Rebmann, V. and Schramm, A. and Künkele, A.
Frontiers in Immunology 11 : 531. 31 March 2020

Reflection of neuroblastoma intratumor heterogeneity in the new OHC-NB1 disease model.
Thole, T.M. and Toedling, J. and Sprüssel, A. and Pfeil, S. and Savelyeva, L. and Capper, D. and Messerschmidt, C. and Beule, D. and Groeneveld-Krentz, S. and Eckert, C. and Gambara, G. and Henssen, A.G. and Finkler, S. and Schulte, J.H. and Sieber, A. and Bluethgen, N. and Regenbrecht, C.R.A. and Künkele, A. and Lodrini, M. and Eggert, A. and Deubzer, H.E.
International Journal of Cancer 146 (4): 1031-1041. 15 February 2020

Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma.
Koche, R.P. and Rodriguez-Fos, E. and Helmsauer, K. and Burkert, M. and MacArthur, I.C. and Maag, J. and Chamorro, R. and Munoz-Perez, N. and Puiggròs, M. and Dorado Garcia, H. and Bei, Y. and Röefzaad, C. and Bardinet, V. and Szymansky, A. and Winkler, A. and Thole, T. and Timme, N. and Kasack, K. and Fuchs, S. and Klironomos, F. and Thiessen, N. and Blanc, E. and Schmelz, K. and Künkele, A. and Hundsdörfer, P. and Rosswog, C. and Theissen, J. and Beule, D. and Deubzer, H. and Sauer, S. and Toedling, J. and Fischer, M. and Hertwig, F. and Schwarz, R.F. and Eggert, A. and Torrents, D. and Schulte, J.H. and Henssen, A.G.
Nature Genetics 52 (1): 29-34. January 2020

Synergistic activity of BET inhibitor MK-8628 and PLK inhibitor Volasertib in preclinical models of medulloblastoma.
Han, Y. and Lindner, S. and Bei, Y. and Garcia, H.D. and Timme, N. and Althoff, K. and Odersky, A. and Schramm, A. and Lissat, A. and Künkele, A. and Deubzer, H.E. and Eggert, A. and Schulte, J.H. and Henssen, A.G.
Cancer Letters 445 : 24-33. 31 March 2019

Reactivating TP53 signaling by the novel MDM2 inhibitor DS-3032b as a therapeutic option for high-risk neuroblastoma.
Arnhold, V. and Schmelz, K. and Proba, J. and Winkler, A. and Wünschel, J. and Toedling, J. and Deubzer, H.E. and Künkele, A. and Eggert, A. and Schulte, J.H. and Hundsdoerfer, P.
Oncotarget 9 (2): 2304-2319. 2018

Using droplet digital PCR to analyze MYCN and ALK copy number in plasma from patients with neuroblastoma.
Lodrini, M. and Sprüssel, A. and Astrahantseff, K. and Tiburtius, D. and Konschak, R. and Lode, H.N. and Fischer, M. and Keilholz, U. and Eggert, A. and Deubzer, H.E.
Oncotarget 8 (49): 85234-85251. 17 October 2017

2017 GPOH guidelines for diagnosis and treatment of patients with neuroblastic tumors.
Simon, T. and Hero, B. and Schulte, J.H. and Deubzer, H. and Hundsdoerfer, P. and von Schweinitz, D. and Fuchs, J. and Schmidt, M. and Prasad, V. and Krug, B. and Timmermann, B. and Leuschner, I. and Fischer, M. and Langer, T. and Astrahantseff, K. and Berthold, F. and Lode, H. and Eggert, A.
Klinische Padiatrie 229 (3): 147-167. May 2017

RITA displays anti-tumor activity in medulloblastomas independent of TP53 status.
Gottlieb, A. and Althoff, K. and Grunewald, L. and Thor, T. and Odersky, A. and Schulte, M. and Deubzer, H.E. and Heukamp, L. and Eggert, A. and Schramm, A. and Schulte, J.H. and Künkele, A.
Oncotarget 8 (17): 27882-27891. 25 April 2017

Neuroblastoma cells depend on HDAC11 for mitotic cell cycle progression and survival.
Thole, T.M. and Lodrini, M. and Fabian, J. and Wuenschel, J. and Pfeil, S. and Hielscher, T. and Kopp-Schneider, A. and Heinicke, U. and Fulda, S. and Witt, O. and Eggert, A. and Fischer, M. and Deubzer, H.E.
Cell Death & Disease 8 (3): e2635. 2 March 2017

The GSK461364 PLK1 inhibitor exhibits strong antitumoral activity in preclinical neuroblastoma models.
Pajtler, K.W. and Sadowski, N. and Ackermann, S. and Althoff, K. and Schönbeck, K. and Batzke, K. and Schäfers, S. and Odersky, A. and Heukamp, L. and Astrahantseff, K. and Künkele, A. and Deubzer, H.E. and Schramm, A. and Sprüssel, A. and Thor, T. and Lindner, S. and Eggert, A. and Fischer, M. and Schulte, J.H.
Oncotarget 8 (4): 6730-6741. 24 January 2017

MYCN and HDAC5 transcriptionally repress CD9 to trigger invasion and metastasis in neuroblastoma.
Fabian, J. and Opitz, D. and Althoff, K. and Lodrini, M. and Hero, B. and Volland, R. and Beckers, A. and de Preter, K. and Decock, A. and Patil, N. and Abba, M. and Kopp-Schneider, A. and Astrahantseff, K. and Wünschel, J. and Pfeil, S. and Ercu, M. and Künkele, A. and Hu, J. and Thole, T. and Schweizer, L. and Mechtersheimer, G. and Carter, D. and Cheung, B.B. and Popanda, O. and von Deimling, A. and Koster, J. and Versteeg, R. and Schwab, M. and Marshall, G.M. and Speleman, F. and Erb, U. and Zoeller, M. and Allgayer, H. and Simon, T. and Fischer, M. and Kulozik, A.E. and Eggert, A. and Witt, O. and Schulte, J.H. and Deubzer, H.E.
Oncotarget 7 (41): 66344-66359. 11 October 2016

Minichromosome maintenance complex is a critical node in the miR-183 signaling network of MYCN-amplified neuroblastoma cells.
Lodrini, M. and Poschmann, G. and Schmidt, V. and Wünschel, J. and Dreidax, D. and Witt, O. and Höfer, T. and Meyer, H.E. and Stühler, K. and Eggert, A. and Deubzer, H.E.
Journal of Proteome Research 15 (7): 2178-2186. 1 July 2016

Targeting class I histone deacetylase 2 in MYC amplified group 3 medulloblastoma.
Ecker, J. and Oehme, I. and Mazitschek, R. and Korshunov, A. and Kool, M. and Hielscher, T. and Kiss, J. and Selt, F. and Konrad, C. and Lodrini, M. and Deubzer, H.E. and von Deimling, A. and Kulozik, A.E. and Pfister, S.M. and Witt, O. and Milde, T.
Acta Neuropathologica Communications 3 : 22. 3 April 2015

Selective inhibition of HDAC8 decreases neuroblastoma growth in vitro and in vivo and enhances retinoic acid-mediated differentiation.
Rettig, I. and Koeneke, E. and Trippel, F. and Mueller, W.C. and Burhenne, J. and Kopp-Schneider, A. and Fabian, J. and Schober, A. and Fernekorn, U. and von Deimling, A. and Deubzer, H.E. and Milde, T. and Witt, O. and Oehme, I.
Cell Death & Disease 6 : e1657. 19 February 2015

GRHL1 acts as tumor suppressor in neuroblastoma and is negatively regulated by MYCN and HDAC3.
Fabian, J. and Lodrini, M. and Oehme, I. and Schier, M.C. and Thole, T.M. and Hielscher, T. and Kopp-Schneider, A. and Opitz, L. and Capper, D. and von Deimling, A. and Wiegand, I. and Milde, T. and Mahlknecht, U. and Westermann, F. and Popanda, O. and Roels, F. and Hero, B. and Berthold, F. and Fischer, M. and Kulozik, A.E. and Witt, O. and Deubzer, H.E.
Cancer Research 74 (9): 2604-2616. 1 May 2014

Histone deacetylase 10 promotes autophagy-mediated cell survival.
Oehme, I. and Linke, J.P. and Böck, B.C. and Milde, T. and Lodrini, M. and Hartenstein, B. and Wiegand, I. and Eckert, C. and Roth, W. and Kool, M. and Kaden, S. and Gröne, H.J. and Schulte, J.H. and Lindner, S. and Hamacher-Brady, A. and Brady, N.R. and Deubzer, H.E. and Witt, O.
Proceedings of the National Academy of Sciences of the United States of America 110 (28): E2592-E2601. 9 July 2013

Small molecule inhibitors of aurora-a induce proteasomal degradation of N-myc in childhood neuroblastoma.
Brockmann, M. and Poon, E. and Berry, T. and Carstensen, A. and Deubzer, H.E. and Rycak, L. and Jamin, Y. and Thway, K. and Robinson, S.P. and Roels, F. and Witt, O. and Fischer, M. and Chesler, L. and Eilers, M.
Cancer Cell 24 (1): 75-89. 8 July 2013

MYCN and HDAC2 cooperate to repress miR-183 signaling in neuroblastoma.
Lodrini, M. and Oehme, I. and Schroeder, C. and Milde, T. and Schier, M.C. and Kopp-Schneider, A. and Schulte, J.H. and Fischer, M. and De Preter, K. and Pattyn, F. and Castoldi, M. and Muckenthaler, M.U. and Kulozik, A.E. and Westermann, F. and Witt, O. and Deubzer, H.E.
Nucleic Acids Research 41 (12): 6018-6033. 1 July 2013

HDAC11 is a novel drug target in carcinomas.
Deubzer, H.E. and Schier, M.C. and Oehme, I. and Lodrini, M. and Haendler, B. and Sommer, A. and Witt, O.
International Journal of Cancer 132 (9): 2200-2208. 1 May 2013

Hox-C9 activates the intrinsic pathway of apoptosis and is associated with spontaneous regression in neuroblastoma.
Kocak, H. and Ackermann, S. and Hero, B. and Kahlert, Y. and Oberthuer, A. and Juraeva, D. and Roels, F. and Theissen, J. and Westermann, F. and Deubzer, H. and Ehemann, V. and Brors, B. and Odenthal, M. and Berthold, F. and Fischer, M.
Cell Death & Disease 4 : e586. 11 April 2013

HD-MB03 is a novel Group 3 medulloblastoma model demonstrating sensitivity to histone deacetylase inhibitor treatment.
Milde, T. and Lodrini, M. and Savelyeva, L. and Korshunov, A. and Kool, M. and Brueckner, L.M. and Antunes, A.S.L.M. and Oehme, I. and Pekrun, A. and Pfister, S.M. and Kulozik, A.E. and Witt, O. and Deubzer, H.E.
Journal of Neuro-Oncology 110 (3): 335-348. December 2012

Nestin expression identifies ependymoma patients with poor outcome.
Milde, T. and Hielscher, T. and Witt, H. and Kool, M. and Mack, S.C. and Deubzer, H.E. and Oehme, I. and Lodrini, M. and Benner, A. and Taylor, M.D. and von Deimling, A. and Kulozik, A.E. and Pfister, S.M. and Witt, O. and Korshunov, A.
Brain Pathology 22 (6): 848-860. November 2012

Phase I/II intra-patient dose escalation study of vorinostat in children with relapsed solid tumor, lymphoma or leukemia.
Witt, O. and Milde, T. and Deubzer, H.E. and Oehme, I. and Witt, R. and Kulozik, A. and Eisenmenger, A. and Abel, U. and Karapanagiotou-Schenkel, I.
Klinische Padiatrie 224 (6): 398-403. October 2012

Pharmacological activation of the p53 pathway by nutlin-3 exerts anti-tumoral effects in medulloblastomas.
Künkele, A. and De Preter, K. and Heukamp, L. and Thor, T. and Pajtler, K.W. and Hartmann, W. and Mittelbronn, M. and Grotzer, M.A. and Deubzer, H.E. and Speleman, F. and Schramm, A. and Eggert, A. and Schulte, J.H.
Neuro-Oncology 14 (7): 859-869. 1 July 2012

A novel human high-risk ependymoma stem cell model reveals the differentiation-inducing potential of the histone deacetylase inhibitor Vorinostat.
Milde, T. and Kleber, S. and Korshunov, A. and Witt, H. and Hielscher, T. and Koch, P. and Kopp, H.G. and Jugold, M. and Deubzer, H.E. and Oehme, I. and Lodrini, M. and Gröne, H.J. and Benner, A. and Brüstle, O. and Gilbertson, R.J. and von Deimling, A. and Kulozik, A.E. and Pfister, S.M. and Martin-Villalba, A. and Witt, O.
Acta Neuropathologica 122 (5): 637-650. November 2011

CAMTA1, a 1p36 tumor suppressor candidate, inhibits growth and activates differentiation programs in neuroblastoma cells.
Henrich, K.O. and Bauer, T. and Schulte, J. and Ehemann, V. and Deubzer, H. and Gogolin, S. and Muth, D. and Fischer, M. and Benner, A. and König, R. and Schwab, M. and Westermann, F.
Cancer Research 71 (8): 3142-3151. 15 April 2011

Enhancement of radiation response in osteosarcoma and rhabdomyosarcoma cell lines by histone deacetylase inhibition.
Blattmann, C. and Oertel, S. and Ehemann, V. and Thiemann, M. and Huber, P.E. and Bischof, M. and Witt, O. and Deubzer, H.E. and Kulozik, A.E. and Debus, J. and Weber, K.J.
International Journal of Radiation Oncology, Biology, Physics 78 (1): 237-245. 1 September 2010

Parvovirus H1 selectively induces cytotoxic effects on human neuroblastoma cells.
Lacroix, J. and Leuchs, B. and Li, J. and Hristov, G. and Deubzer, H.E. and Kulozik, A.E. and Rommelaere, J. and Schlehofer, J.R. and Witt, O.
International Journal of Cancer 127 (5): 1230-1239. 1 September 2010

HDAC5 and HDAC9 in medulloblastoma: novel markers for risk stratification and role in tumor cell growth.
Milde, T. and Oehme, I. and Korshunov, A. and Kopp-Schneider, A. and Remke, M. and Northcott, P. and Deubzer, H.E. and Lodrini, M. and Taylor, M.D. and von Deimling, A. and Pfister, S. and Witt, O.
Clinical Cancer Research 16 (12): 3240-3252. 15 June 2010

Anti-cancer effects of artesunate in a panel of chemoresistant neuroblastoma cell lines.
Michaelis, M. and Kleinschmidt, M.C. and Barth, S. and Rothweiler, F. and Geiler, J. and Breitling, R. and Mayer, B. and Deubzer, H. and Witt, O. and Kreuter, J. and Doerr, H.W. and Cinatl, J. and Cinatl, J.
Biochemical Pharmacology 79 (2): 130-136. 15 January 2010

Stepwise accumulation of distinct genomic aberrations in a patient with progressively metastasizing ependymoma.
Milde, T. and Pfister, S. and Korshunov, K. and Deubzer, H.E. and Oehme, I. and Ernst, A. and Starzinski-Powitz, A. and Seitz, A. and Lichter, P. and von Deimling, A. and Witt, O.
Genes Chromosomes & Cancer 48 (3): 229-238. March 2009

Histone deacetylase 8 in neuroblastoma tumorigenesis.
Oehme, I. and Deubzer, H.E. and Wegener, D. and Pickert, D. and Linke, J.P. and Hero, B. and Kopp-Schneider, A. and Westermann, F. and Ulrich, S.M. and von Deimling, A. and Fischer, M. and Witt, O.
Clinical Cancer Research 15 (1): 91-99. January 2009

Transcription factor AP2alpha (TFAP2a) regulates differentiation and proliferation of neuroblastoma cells.
Schulte, J.H. and Kirfel, J. and Lim, S. and Schramm, A. and Friedrichs, N. and Deubzer, H.E. and Witt, O. and Eggert, A. and Buettner, R.
Cancer Letters 271 (1): 56-63. 18 November 2008

Cisplatin-resistant neuroblastoma cells express enhanced levels of epidermal growth factor receptor (EGFR) and are sensitive to treatment with EGFR-specific toxins.
Michaelis, M. and Bliss, J. and Arnold, S.C. and Hinsch, N. and Rothweiler, F. and Deubzer, H.E. and Witt, O. and Langer, K. and Doerr, H.W. and Wels, W.S. and Cinatl, J.
Clinical Cancer Research 14 (20): 6531-6537. 16 October 2008

HKI 46F08, a novel potent histone deacetylase inhibitor, exhibits antitumoral activity against embryonic childhood cancer cells.
Wegener, D. and Deubzer, H.E. and Oehme, I. and Milde, T. and Hildmann, C. and Schwienhorst, A. and Witt, O.
Anti-Cancer Drugs 19 (9): 849-857. October 2008

Identification of novel small-molecule histone deacetylase inhibitors by medium-throughput screening using a fluorigenic assay.
Wegener, D. and Hildmann, C. and Riester, D. and Schober, A. and Meyer-Almes, F.J. and Deubzer, H.E. and Oehme, I. and Witt, O. and Lang, S. and Jaensch, M. and Makarov, V. and Lange, C. and Busse, B. and Schwienhorst, A.
Biochemical Journal 413 (1): 143-150. 1 July 2008

Anti-neuroblastoma activity of Helminthosporium carbonum (HC)-toxin is superior to that of other differentiating compounds in vitro.
Deubzer, H.E. and Ehemann, V. and Kulozik, A.E. and Westermann, F. and Savelyeva, L. and Kopp-Schneider, A. and Riester, D. and Schwab, M. and Witt, O.
Cancer Letters 264 (1): 21-28. 8 June 2008

Histone deacetylase inhibitor Helminthosporium carbonum (HC)-toxin suppresses the malignant phenotype of neuroblastoma cells.
Deubzer, H.E. and Ehemann, V. and Westermann, F. and Heinrich, R. and Mechtersheimer, G. and Kulozik, A.E. and Schwab, M. and Witt, O.
International Journal of Cancer 122 (8): 1891-900. 15 April 2008

Novel valproic acid derivatives with potent differentiation-inducing activity in myeloid leukemia cells.
Deubzer, H. and Busche, B. and Rönndahl, G. and Eikel, D. and Michaelis, M. and Cinatl, J. and Schulze, S. and Nau, H. and Witt, O.
Leukemia Research 30 (9): 1167-1175. September 2006

Colostrum obtained from women vaccinated with pneumococcal vaccine during pregnancy inhibits epithelial adhesion of Streptococcus pneumoniae.
Deubzer, H.E. and Obaro, S.K. and Newman, V.O. and Adegbola, R.A. and Greenwood, B.M. and Henderson, D.C.
Journal of Infectious Diseases 190 (10): 1758-1761. 15 November 2004

Serotype-specific pneumococcal antibodies in breast milk of Gambian women immunized with a pneumococcal polysaccharide vaccine during pregnancy.
Obaro, S.K. and Deubzer, H.E. and Newman, V.O. and Adegbola, R.A. and Greenwood, B.M. and Henderson, D.C.
Pediatric Infectious Disease Journal 23 (11): 1023-1029. November 2004

Review

Management of malignant dysgerminoma of the ovary.
Arndt, T. and Taube, E.T. and Deubzer, H.E. and Rothe, K. and Calaminus, G. and Sehouli, J. and Pietzner, K.
European Journal of Gynaecological Oncology 43 (2): 353-362. 15 April 2022

Personalisierte Medizin in der Kinderonkologie: Wo stehen wir heute?
Deubzer, H.E. and Schulte, J.H. and Eggert, A.
TumorDiagnostik & Therapie 43 (01): 29-44. February 2022

Personalisierte Medizin in der Kinderonkologie: Wo stehen wir heute?
Deubzer, H.E. and Schulte, J.H. and Eggert, A.
Pädiatrie up2date 16 (4): 325-342. December 2021

Accelerating drug development for neuroblastoma: summary of the Second Neuroblastoma Drug Development Strategy forum from Innovative Therapies for Children with Cancer and International Society of Paediatric Oncology Europe Neuroblastoma.
Moreno, L. and Barone, G. and DuBois, S.G. and Molenaar, J. and Fischer, M. and Schulte, J. and Eggert, A. and Schleiermacher, G. and Speleman, F. and Chesler, L. and Geoerger, B. and Hogarty, M.D. and Irwin, M.S. and Bird, N. and Blanchard, G.B. and Buckland, S. and Caron, H. and Davis, S. and De Wilde, B. and Deubzer, H.E. and Dolman, E. and Eilers, M. and George, R.E. and George, S. and Jaroslav, Š. and Maris, J.M. and Marshall, L. and Merchant, M. and Mortimer, P. and Owens, C. and Philpott, A. and Poon, E. and Shay, J.W. and Tonelli, R. and Valteau-Couanet, D. and Vassal, G. and Park, J.R. and Pearson, A.D.J.
European Journal of Cancer 136 : 52-68. September 2020

The pitfalls and promise of liquid biopsies for diagnosing and treating solid tumors in children: a review.
Van Paemel, R. and Vlug, R. and De Preter, K. and Van Roy, N. and Speleman, F. and Willems, L. and Lammens, T. and Laureys, G. and Schleiermacher, G. and Tytgat, G.A.M. and Astrahantseff, K. and Deubzer, H. and De Wilde, B.
European Journal of Pediatrics 179 : 191-202. February 2020

Childhood cancer predisposition syndromes - a concise review and recommendations by the Cancer Predisposition Working Group of the Society for Pediatric Oncology and Hematology.
Ripperger, T. and Bielack, S.S. and Borkhardt, A. and Brecht, I.B. and Burkhardt, B. and Calaminus, G. and Debatin, K.M. and Deubzer, H. and Dirksen, U. and Eckert, C. and Eggert, A. and Erlacher, M. and Fleischhack, G. and Frühwald, M.C. and Gnekow, A. and Goehring, G. and Graf, N. and Hanenberg, H. and Hauer, J. and Hero, B. and Hettmer, S. and von Hoff, K. and Horstmann, M. and Hoyer, J. and Illig, T. and Kaatsch, P. and Kappler, R. and Kerl, K. and Klingebiel, T. and Kontny, U. and Kordes, U. and Körholz, D. and Koscielniak, E. and Kramm, C.M. and Kuhlen, M. and Kulozik, A.E. and Lamottke, B. and Leuschner, I. and Lohmann, D.R. and Meinhardt, A. and Metzler, M. and Meyer, L.H. and Moser, O. and Nathrath, M. and Niemeyer, C.M. and Nustede, R. and Pajtler, K.W. and Paret, C. and Rasche, M. and Reinhardt, D. and Rieß, O. and Russo, A. and Rutkowski, S. and Schlegelberger, B. and Schneider, D. and Schneppenheim, R. and Schrappe, M. and Schroeder, C. and von Schweinitz, D. and Simon, T. and Sparber-Sauer, M. and Spix, C. and Stanulla, M. and Steinemann, D. and Strahm, B. and Temming, P. and Thomay, K. and von Bueren, A.O. and Vorwerk, P. and Witt, O. and Wlodarski, M. and Wössmann, W. and Zenker, M. and Zimmermann, S. and Pfister, S.M. and Kratz, C.P.
American Journal of Medical Genetics Part A 173 (4): 1017-1037. April 2017

Neuroblastoma imaging.
Ley, S. and Ley-Zaporozhan, J. and Günther, P. and Deubzer, H.E. and Witt, O. and Schenk, J.P.
RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin 183 (3): 217-225. March 2011

Targeting of HDAC8 and investigational inhibitors in neuroblastoma.
Oehme, I. and Deubzer, H.E. and Lodrini, M. and Milde, T. and Witt, O.
Expert Opinion on Investigational Drugs 18 (11): 1605-1617. November 2009

HDAC family: What are the cancer relevant targets?
Witt, O. and Deubzer, H.E. and Milde, T. and Oehme, I.
Cancer Letters 277 (1): 8-21. 8 May 2009

Targeting histone deacetylases in neuroblastoma.
Witt, O. and Deubzer, H.E. and Lodrini, M. and Milde, T. and Oehme, I.
Current Pharmaceutical Design 15 (4): 436-447. 2009

Letter

Rituximab therapy after pediatric hematopoietic stem cell transplantation can cause prolonged B cell impairment and increases the risk for infections - a retrospective matched cohort study.
Launspach, M. and Temel, D. and Ohlendorf, E. and Zirngibl, F. and Materne, B. and Oevermann, L. and Deubzer, H.E. and Henssen, A.G. and Künkele, A. and Hundsdörfer, P. and von Bernuth, H. and Pruß, A. and Eggert, A. and von Stackelberg, A. and Lang, P. and Schulte, J.H.
Haematologica 108 (1): 267-272. January 2023

Transmission of chromosomally integrated human herpes virus-6A via haploidentical stem cell transplantation poses a risk for virus reactivation and associated complications.
Oevermann, L. and Zimmermann, C. and Voigt, S. and Künkele, A. and Lobitz, S. and Eggert, A. and Schulte, J.H. and Kaufer, B.B. and Deubzer, H.E.
Bone Marrow Transplantation 55 (1): 260-264. January 2020

Editorial

A deep dive into the circulating ctDNA cosmos to vanquish neuroblastoma.
Deubzer, H.E. and Astrahantseff, K. and Lodrini, M.
Cancer Discovery 12 (12): 2727-2729. 2 December 2022

Melanozytäre Naevi der Haut bei einem Neugeborenen [Dermal melanocytic nevi in a newborn].
Endres, S. and Wilke, M. and Höche, A. and Gertz, A. and Schubert, R. and Deubzer, H. and Eggert, A. and Rossi, R. and Schlembach, D.
Gynäkologe 53 (8): 554-556. August 2020