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2018

Reactivating TP53 signaling by the novel MDM2 inhibitor DS-3032b as a therapeutic option for high-risk neuroblastoma.
Arnhold, V. and Schmelz, K. and Proba, J. and Winkler, A. and Wünschel, J. and Toedling, J. and Deubzer, H.E. and Künkele, A. and Eggert, A. and Schulte, J.H. and Hundsdoerfer, P.
Oncotarget 9 (2): 2304-2319. 2018

2017

Using droplet digital PCR to analyze MYCN and ALK copy number in plasma from patients with neuroblastoma.
Lodrini, M. and Sprüssel, A. and Astrahantseff, K. and Tiburtius, D. and Konschak, R. and Lode, H.N. and Fischer, M. and Keilholz, U. and Eggert, A. and Deubzer, H.E.
Oncotarget 8 (49): 85234-85251. 17 October 2017

2017 GPOH guidelines for diagnosis and treatment of patients with neuroblastic tumors.
Simon, T. and Hero, B. and Schulte, J.H. and Deubzer, H. and Hundsdoerfer, P. and von Schweinitz, D. and Fuchs, J. and Schmidt, M. and Prasad, V. and Krug, B. and Timmermann, B. and Leuschner, I. and Fischer, M. and Langer, T. and Astrahantseff, K. and Berthold, F. and Lode, H. and Eggert, A.
Klinische Padiatrie 229 (3): 147-167. May 2017

RITA displays anti-tumor activity in medulloblastomas independent of TP53 status.
Gottlieb, A. and Althoff, K. and Grunewald, L. and Thor, T. and Odersky, A. and Schulte, M. and Deubzer, H.E. and Heukamp, L. and Eggert, A. and Schramm, A. and Schulte, J.H. and Künkele, A.
Oncotarget 8 (17): 27882-27891. 25 April 2017

Childhood cancer predisposition syndromes - a concise review and recommendations by the Cancer Predisposition Working Group of the Society for Pediatric Oncology and Hematology.
Ripperger, T. and Bielack, S.S. and Borkhardt, A. and Brecht, I.B. and Burkhardt, B. and Calaminus, G. and Debatin, K.M. and Deubzer, H. and Dirksen, U. and Eckert, C. and Eggert, A. and Erlacher, M. and Fleischhack, G. and Frühwald, M.C. and Gnekow, A. and Goehring, G. and Graf, N. and Hanenberg, H. and Hauer, J. and Hero, B. and Hettmer, S. and von Hoff, K. and Horstmann, M. and Hoyer, J. and Illig, T. and Kaatsch, P. and Kappler, R. and Kerl, K. and Klingebiel, T. and Kontny, U. and Kordes, U. and Körholz, D. and Koscielniak, E. and Kramm, C.M. and Kuhlen, M. and Kulozik, A.E. and Lamottke, B. and Leuschner, I. and Lohmann, D.R. and Meinhardt, A. and Metzler, M. and Meyer, L.H. and Moser, O. and Nathrath, M. and Niemeyer, C.M. and Nustede, R. and Pajtler, K.W. and Paret, C. and Rasche, M. and Reinhardt, D. and Rieß, O. and Russo, A. and Rutkowski, S. and Schlegelberger, B. and Schneider, D. and Schneppenheim, R. and Schrappe, M. and Schroeder, C. and von Schweinitz, D. and Simon, T. and Sparber-Sauer, M. and Spix, C. and Stanulla, M. and Steinemann, D. and Strahm, B. and Temming, P. and Thomay, K. and von Bueren, A.O. and Vorwerk, P. and Witt, O. and Wlodarski, M. and Wössmann, W. and Zenker, M. and Zimmermann, S. and Pfister, S.M. and Kratz, C.P.
American Journal of Medical Genetics Part A 173 (4): 1017-1037. April 2017

Neuroblastoma cells depend on HDAC11 for mitotic cell cycle progression and survival.
Thole, T.M. and Lodrini, M. and Fabian, J. and Wuenschel, J. and Pfeil, S. and Hielscher, T. and Kopp-Schneider, A. and Heinicke, U. and Fulda, S. and Witt, O. and Eggert, A. and Fischer, M. and Deubzer, H.E.
Cell Death & Disease 8 (3): e2635. 2 March 2017

The GSK461364 PLK1 inhibitor exhibits strong antitumoral activity in preclinical neuroblastoma models.
Pajtler, K.W. and Sadowski, N. and Ackermann, S. and Althoff, K. and Schönbeck, K. and Batzke, K. and Schäfers, S. and Odersky, A. and Heukamp, L. and Astrahantseff, K. and Künkele, A. and Deubzer, H.E. and Schramm, A. and Sprüssel, A. and Thor, T. and Lindner, S. and Eggert, A. and Fischer, M. and Schulte, J.H.
Oncotarget 8 (4): 6730-6741. 24 January 2017

2016

MYCN and HDAC5 transcriptionally repress CD9 to trigger invasion and metastasis in neuroblastoma.
Fabian, J. and Opitz, D. and Althoff, K. and Lodrini, M. and Hero, B. and Volland, R. and Beckers, A. and de Preter, K. and Decock, A. and Patil, N. and Abba, M. and Kopp-Schneider, A. and Astrahantseff, K. and Wünschel, J. and Pfeil, S. and Ercu, M. and Künkele, A. and Hu, J. and Thole, T. and Schweizer, L. and Mechtersheimer, G. and Carter, D. and Cheung, B.B. and Popanda, O. and von Deimling, A. and Koster, J. and Versteeg, R. and Schwab, M. and Marshall, G.M. and Speleman, F. and Erb, U. and Zoeller, M. and Allgayer, H. and Simon, T. and Fischer, M. and Kulozik, A.E. and Eggert, A. and Witt, O. and Schulte, J.H. and Deubzer, H.E.
Oncotarget 7 (41): 66344-66359. 11 October 2016

Minichromosome maintenance complex is a critical node in the miR-183 signaling network of MYCN-amplified neuroblastoma cells.
Lodrini, M. and Poschmann, G. and Schmidt, V. and Wünschel, J. and Dreidax, D. and Witt, O. and Höfer, T. and Meyer, H.E. and Stühler, K. and Eggert, A. and Deubzer, H.E.
Journal of Proteome Research 15 (7): 2178-2186. 1 July 2016

2015

Targeting class I histone deacetylase 2 in MYC amplified group 3 medulloblastoma.
Ecker, J. and Oehme, I. and Mazitschek, R. and Korshunov, A. and Kool, M. and Hielscher, T. and Kiss, J. and Selt, F. and Konrad, C. and Lodrini, M. and Deubzer, H.E. and von Deimling, A. and Kulozik, A.E. and Pfister, S.M. and Witt, O. and Milde, T.
Acta Neuropathologica Communications 3 : 22. 3 April 2015

Selective inhibition of HDAC8 decreases neuroblastoma growth in vitro and in vivo and enhances retinoic acid-mediated differentiation.
Rettig, I. and Koeneke, E. and Trippel, F. and Mueller, W.C. and Burhenne, J. and Kopp-Schneider, A. and Fabian, J. and Schober, A. and Fernekorn, U. and von Deimling, A. and Deubzer, H.E. and Milde, T. and Witt, O. and Oehme, I.
Cell Death & Disease 6 : e1657. 19 February 2015

2014

GRHL1 acts as tumor suppressor in neuroblastoma and is negatively regulated by MYCN and HDAC3.
Fabian, J. and Lodrini, M. and Oehme, I. and Schier, M.C. and Thole, T.M. and Hielscher, T. and Kopp-Schneider, A. and Opitz, L. and Capper, D. and von Deimling, A. and Wiegand, I. and Milde, T. and Mahlknecht, U. and Westermann, F. and Popanda, O. and Roels, F. and Hero, B. and Berthold, F. and Fischer, M. and Kulozik, A.E. and Witt, O. and Deubzer, H.E.
Cancer Research 74 (9): 2604-2616. 1 May 2014

2013

Histone deacetylase 10 promotes autophagy-mediated cell survival.
Oehme, I. and Linke, J.P. and Böck, B.C. and Milde, T. and Lodrini, M. and Hartenstein, B. and Wiegand, I. and Eckert, C. and Roth, W. and Kool, M. and Kaden, S. and Gröne, H.J. and Schulte, J.H. and Lindner, S. and Hamacher-Brady, A. and Brady, N.R. and Deubzer, H.E. and Witt, O.
Proceedings of the National Academy of Sciences of the United States of America 110 (28): E2592-E2601. 9 July 2013

Small molecule inhibitors of aurora-a induce proteasomal degradation of N-myc in childhood neuroblastoma.
Brockmann, M. and Poon, E. and Berry, T. and Carstensen, A. and Deubzer, H.E. and Rycak, L. and Jamin, Y. and Thway, K. and Robinson, S.P. and Roels, F. and Witt, O. and Fischer, M. and Chesler, L. and Eilers, M.
Cancer Cell 24 (1): 75-89. 8 July 2013

MYCN and HDAC2 cooperate to repress miR-183 signaling in neuroblastoma.
Lodrini, M. and Oehme, I. and Schroeder, C. and Milde, T. and Schier, M.C. and Kopp-Schneider, A. and Schulte, J.H. and Fischer, M. and De Preter, K. and Pattyn, F. and Castoldi, M. and Muckenthaler, M.U. and Kulozik, A.E. and Westermann, F. and Witt, O. and Deubzer, H.E.
Nucleic Acids Research 41 (12): 6018-6033. 1 July 2013

HDAC11 is a novel drug target in carcinomas.
Deubzer, H.E. and Schier, M.C. and Oehme, I. and Lodrini, M. and Haendler, B. and Sommer, A. and Witt, O.
International Journal of Cancer 132 (9): 2200-2208. 1 May 2013

Hox-C9 activates the intrinsic pathway of apoptosis and is associated with spontaneous regression in neuroblastoma.
Kocak, H. and Ackermann, S. and Hero, B. and Kahlert, Y. and Oberthuer, A. and Juraeva, D. and Roels, F. and Theissen, J. and Westermann, F. and Deubzer, H. and Ehemann, V. and Brors, B. and Odenthal, M. and Berthold, F. and Fischer, M.
Cell Death & Disease 4 : e586. 11 April 2013

2012

HD-MB03 is a novel Group 3 medulloblastoma model demonstrating sensitivity to histone deacetylase inhibitor treatment.
Milde, T. and Lodrini, M. and Savelyeva, L. and Korshunov, A. and Kool, M. and Brueckner, L.M. and Antunes, A.S.L.M. and Oehme, I. and Pekrun, A. and Pfister, S.M. and Kulozik, A.E. and Witt, O. and Deubzer, H.E.
Journal of Neuro-Oncology 110 (3): 335-348. December 2012

Nestin expression identifies ependymoma patients with poor outcome.
Milde, T. and Hielscher, T. and Witt, H. and Kool, M. and Mack, S.C. and Deubzer, H.E. and Oehme, I. and Lodrini, M. and Benner, A. and Taylor, M.D. and von Deimling, A. and Kulozik, A.E. and Pfister, S.M. and Witt, O. and Korshunov, A.
Brain Pathology 22 (6): 848-860. November 2012

Phase I/II intra-patient dose escalation study of vorinostat in children with relapsed solid tumor, lymphoma or leukemia.
Witt, O. and Milde, T. and Deubzer, H.E. and Oehme, I. and Witt, R. and Kulozik, A. and Eisenmenger, A. and Abel, U. and Karapanagiotou-Schenkel, I.
Klinische Padiatrie 224 (6): 398-403. October 2012

Pharmacological activation of the p53 pathway by nutlin-3 exerts anti-tumoral effects in medulloblastomas.
Künkele, A. and De Preter, K. and Heukamp, L. and Thor, T. and Pajtler, K.W. and Hartmann, W. and Mittelbronn, M. and Grotzer, M.A. and Deubzer, H.E. and Speleman, F. and Schramm, A. and Eggert, A. and Schulte, J.H.
Neuro-Oncology 14 (7): 859-869. 1 July 2012

2011

A novel human high-risk ependymoma stem cell model reveals the differentiation-inducing potential of the histone deacetylase inhibitor Vorinostat.
Milde, T. and Kleber, S. and Korshunov, A. and Witt, H. and Hielscher, T. and Koch, P. and Kopp, H.G. and Jugold, M. and Deubzer, H.E. and Oehme, I. and Lodrini, M. and Gröne, H.J. and Benner, A. and Brüstle, O. and Gilbertson, R.J. and von Deimling, A. and Kulozik, A.E. and Pfister, S.M. and Martin-Villalba, A. and Witt, O.
Acta Neuropathologica 122 (5): 637-650. November 2011

CAMTA1, a 1p36 tumor suppressor candidate, inhibits growth and activates differentiation programs in neuroblastoma cells.
Henrich, K.O. and Bauer, T. and Schulte, J. and Ehemann, V. and Deubzer, H. and Gogolin, S. and Muth, D. and Fischer, M. and Benner, A. and König, R. and Schwab, M. and Westermann, F.
Cancer Research 71 (8): 3142-3151. 15 April 2011

Neuroblastoma imaging.
Ley, S. and Ley-Zaporozhan, J. and Günther, P. and Deubzer, H.E. and Witt, O. and Schenk, J.P.
RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin 183 (3): 217-225. March 2011

2010

Enhancement of radiation response in osteosarcoma and rhabdomyosarcoma cell lines by histone deacetylase inhibition.
Blattmann, C. and Oertel, S. and Ehemann, V. and Thiemann, M. and Huber, P.E. and Bischof, M. and Witt, O. and Deubzer, H.E. and Kulozik, A.E. and Debus, J. and Weber, K.J.
International Journal of Radiation Oncology, Biology, Physics 78 (1): 237-245. 1 September 2010

Parvovirus H1 selectively induces cytotoxic effects on human neuroblastoma cells.
Lacroix, J. and Leuchs, B. and Li, J. and Hristov, G. and Deubzer, H.E. and Kulozik, A.E. and Rommelaere, J. and Schlehofer, J.R. and Witt, O.
International Journal of Cancer 127 (5): 1230-1239. 1 September 2010

HDAC5 and HDAC9 in medulloblastoma: novel markers for risk stratification and role in tumor cell growth.
Milde, T. and Oehme, I. and Korshunov, A. and Kopp-Schneider, A. and Remke, M. and Northcott, P. and Deubzer, H.E. and Lodrini, M. and Taylor, M.D. and von Deimling, A. and Pfister, S. and Witt, O.
Clinical Cancer Research 16 (12): 3240-3252. 15 June 2010

Anti-cancer effects of artesunate in a panel of chemoresistant neuroblastoma cell lines.
Michaelis, M. and Kleinschmidt, M.C. and Barth, S. and Rothweiler, F. and Geiler, J. and Breitling, R. and Mayer, B. and Deubzer, H. and Witt, O. and Kreuter, J. and Doerr, H.W. and Cinatl, J. and Cinatl, J.
Biochemical Pharmacology 79 (2): 130-136. 15 January 2010

2009

Targeting of HDAC8 and investigational inhibitors in neuroblastoma.
Oehme, I. and Deubzer, H.E. and Lodrini, M. and Milde, T. and Witt, O.
Expert Opinion on Investigational Drugs 18 (11): 1605-1617. November 2009

HDAC family: What are the cancer relevant targets?
Witt, O. and Deubzer, H.E. and Milde, T. and Oehme, I.
Cancer Letters 277 (1): 8-21. 8 May 2009

Stepwise accumulation of distinct genomic aberrations in a patient with progressively metastasizing ependymoma.
Milde, T. and Pfister, S. and Korshunov, K. and Deubzer, H.E. and Oehme, I. and Ernst, A. and Starzinski-Powitz, A. and Seitz, A. and Lichter, P. and von Deimling, A. and Witt, O.
Genes Chromosomes & Cancer 48 (3): 229-238. March 2009

Histone deacetylase 8 in neuroblastoma tumorigenesis.
Oehme, I. and Deubzer, H.E. and Wegener, D. and Pickert, D. and Linke, J.P. and Hero, B. and Kopp-Schneider, A. and Westermann, F. and Ulrich, S.M. and von Deimling, A. and Fischer, M. and Witt, O.
Clinical Cancer Research 15 (1): 91-99. January 2009

Targeting histone deacetylases in neuroblastoma.
Witt, O. and Deubzer, H.E. and Lodrini, M. and Milde, T. and Oehme, I.
Current Pharmaceutical Design 15 (4): 436-447. 2009

2008

Transcription factor AP2alpha (TFAP2a) regulates differentiation and proliferation of neuroblastoma cells.
Schulte, J.H. and Kirfel, J. and Lim, S. and Schramm, A. and Friedrichs, N. and Deubzer, H.E. and Witt, O. and Eggert, A. and Buettner, R.
Cancer Letters 271 (1): 56-63. 18 November 2008

Cisplatin-resistant neuroblastoma cells express enhanced levels of epidermal growth factor receptor (EGFR) and are sensitive to treatment with EGFR-specific toxins.
Michaelis, M. and Bliss, J. and Arnold, S.C. and Hinsch, N. and Rothweiler, F. and Deubzer, H.E. and Witt, O. and Langer, K. and Doerr, H.W. and Wels, W.S. and Cinatl, J.
Clinical Cancer Research 14 (20): 6531-6537. 16 October 2008

HKI 46F08, a novel potent histone deacetylase inhibitor, exhibits antitumoral activity against embryonic childhood cancer cells.
Wegener, D. and Deubzer, H.E. and Oehme, I. and Milde, T. and Hildmann, C. and Schwienhorst, A. and Witt, O.
Anti-Cancer Drugs 19 (9): 849-857. October 2008

Identification of novel small-molecule histone deacetylase inhibitors by medium-throughput screening using a fluorigenic assay.
Wegener, D. and Hildmann, C. and Riester, D. and Schober, A. and Meyer-Almes, F.J. and Deubzer, H.E. and Oehme, I. and Witt, O. and Lang, S. and Jaensch, M. and Makarov, V. and Lange, C. and Busse, B. and Schwienhorst, A.
Biochemical Journal 413 (1): 143-150. 1 July 2008

Anti-neuroblastoma activity of Helminthosporium carbonum (HC)-toxin is superior to that of other differentiating compounds in vitro.
Deubzer, H.E. and Ehemann, V. and Kulozik, A.E. and Westermann, F. and Savelyeva, L. and Kopp-Schneider, A. and Riester, D. and Schwab, M. and Witt, O.
Cancer Letters 264 (1): 21-28. 8 June 2008

Histone deacetylase inhibitor Helminthosporium carbonum (HC)-toxin suppresses the malignant phenotype of neuroblastoma cells.
Deubzer, H.E. and Ehemann, V. and Westermann, F. and Heinrich, R. and Mechtersheimer, G. and Kulozik, A.E. and Schwab, M. and Witt, O.
International Journal of Cancer 122 (8): 1891-900. 15 April 2008

2006

Novel valproic acid derivatives with potent differentiation-inducing activity in myeloid leukemia cells.
Deubzer, H. and Busche, B. and Rönndahl, G. and Eikel, D. and Michaelis, M. and Cinatl, J. and Schulze, S. and Nau, H. and Witt, O.
Leukemia Research 30 (9): 1167-1175. September 2006

2004

Colostrum obtained from women vaccinated with pneumococcal vaccine during pregnancy inhibits epithelial adhesion of Streptococcus pneumoniae.
Deubzer, H.E. and Obaro, S.K. and Newman, V.O. and Adegbola, R.A. and Greenwood, B.M. and Henderson, D.C.
Journal of Infectious Diseases 190 (10): 1758-1761. 15 November 2004

Serotype-specific pneumococcal antibodies in breast milk of Gambian women immunized with a pneumococcal polysaccharide vaccine during pregnancy.
Obaro, S.K. and Deubzer, H.E. and Newman, V.O. and Adegbola, R.A. and Greenwood, B.M. and Henderson, D.C.
Pediatric Infectious Disease Journal 23 (11): 1023-1029. November 2004

This list was generated on Thu Nov 15 02:17:46 2018 CET.
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