Browse by Research Team

2023

Ethanol deprivation and central 5-HT deficiency differentially affect the mRNA editing of the 5-HT(2C) receptor in the mouse brain.
Zaniewska, M. and Alenina, N. and Fröhler, S. and Chen, W. and Bader, M.
Pharmacological Reports 75 (6): 1502-1521. December 2023

2021

Profiling of sub-lethal in vitro effects of multi-walled carbon nanotubes reveals changes in chemokines and chemokine receptors.
Keshavan, S. and Andón, F.T. and Gallud, A. and Chen, W. and Reinert, K. and Tran, L. and Fadeel, B.
Nanomaterials 11 (4): 883. 30 March 2021

Transcriptional repression of NFKBIA triggers constitutive IKK- and proteasome-independent p65/RelA activation in senescence.
Kolesnichenko, M. and Mikuda, N. and Höpken, U.E. and Kärgel, E. and Uyar, B. and Tufan, A.B. and Milanovic, M. and Sun, W. and Krahn, I. and Schleich, K. and von Hoff, L. and Hinz, M. and Willenbrock, M. and Jungmann, S. and Akalin, A. and Lee, S. and Schmidt-Ullrich, R. and Schmitt, C.A. and Scheidereit, C.
EMBO Journal 40 (6): e104296. 15 March 2021

Rbm10 facilitates heterochromatin assembly via the Clr6 HDAC complex.
Weigt, M. and Gao, Q. and Ban, H. and He, H. and Mastrobuoni, G. and Kempa, S. and Chen, W. and Li, F.
Epigenetics & Chromatin 14 (1): 8. 19 January 2021

2020

Long noncoding RNA TYKRIL plays a role in pulmonary hypertension via the p53-mediated regulation of PDGFRβ.
Zehendner, C.M. and Valasarajan, C. and Werner, A. and Boeckel, J.N. and Bischoff, F.C. and John, D. and Weirick, T. and Glaser, S.F. and Rossbach, O. and Jaé, N. and Demolli, S. and Khassafi, F. and Yuan, K. and de Jesus Perez, V.A. and Michalik, K.M. and Chen, W. and Seeger, W. and Guenther, A. and Wasnick, R.M. and Uchida, S. and Zeiher, A.M. and Dimmeler, S. and Pullamsetti, S.S.
American Journal of Respiratory and Critical Care Medicine 202 (10): 1445-1457. 15 November 2020

DNA sonication inverse PCR for genome scale analysis of uncharacterized flanking sequences.
Alquezar‐Planas, D.E. and Löber, U. and Cui, P. and Quedenau, C. and Chen, W. and Greenwood, A.D.
Methods in Ecology and Evolution 22 September 2020

FAM46B is a prokaryotic-like cytoplasmic poly(A) polymerase essential in human embryonic stem cells.
Hu, J.L. and Liang, H. and Zhang, H. and Yang, M.Z. and Sun, W. and Zhang, P. and Luo, L. and Feng, J.X. and Bai, H. and Liu, F. and Zhang, T. and Yang, J.Y. and Gao, Q. and Long, Y. and Ma, X.Y. and Chen, Y. and Zhong, Q. and Yu, B. and Liao, S. and Wang, Y. and Zhao, Y. and Zeng, M.S. and Cao, N. and Wang, J. and Chen, W. and Yang, H.T. and Gao, S.
Nucleic Acids Research 48 (5): 2733-2748. 18 March 2020

Inhibiting WNT and NOTCH in renal cancer stem cells and the implications for human patients.
Fendler, A. and Bauer, D. and Busch, J. and Jung, K. and Wulf-Goldenberg, A. and Kunz, S. and Song, K. and Myszczyszyn, A. and Elezkurtaj, S. and Erguen, B. and Jung, S. and Chen, W. and Birchmeier, W.
Nature Communications 11 (1): 929. 17 February 2020

2019

Proteomic and transcriptomic changes in hibernating grizzly bears reveal metabolic and signaling pathways that protect against muscle atrophy.
Mugahid, D.A. and Sengul, T.G. and You, X. and Wang, Y. and Steil, L. and Bergmann, N. and Radke, M.H. and Ofenbauer, A. and Gesell-Salazar, M. and Balogh, A. and Kempa, S. and Tursun, B. and Robbins, C.T. and Völker, U. and Chen, W. and Nelson, L. and Gotthardt, M.
Scientific Reports 9 (1): 19976. 27 December 2019

The dynamic proteome of influenza A virus infection identifies M segment splicing as a host range determinant.
Bogdanow, B. and Wang, X. and Eichelbaum, K. and Sadewasser, A. and Husic, I. and Paki, K. and Budt, M. and Hergeselle, M. and Vetter, B. and Hou, J. and Chen, W. and Wiebusch, L. and Meyer, I.M. and Wolff, T. and Selbach, M.
Nature Communications 10 (1): 5518. 4 December 2019

Full-length transcriptome reconstruction reveals a large diversity of RNA and protein isoforms in rat hippocampus.
Wang, X. and You, X. and Langer, J.D. and Hou, J. and Rupprecht, F. and Vlatkovic, I. and Quedenau, C. and Tushev, G. and Epstein, I. and Schaefke, B. and Sun, W. and Fang, L. and Li, G. and Hu, Y. and Schuman, E.M. and Chen, W.
Nature Communications 10 (1): 5009. 1 November 2019

A missense mutation in SNRPE linked to non-syndromal microcephaly interferes with U snRNP assembly and pre-mRNA splicing.
Chen, T. and Zhang, B. and Ziegenhals, T. and Prusty, A.B. and Fröhler, S. and Grimm, C. and Hu, Y. and Schaefke, B. and Fang, L. and Zhang, M. and Kraemer, N. and Kaindl, A.M. and Fischer, U. and Chen, W.
PLoS Genetics 15 (10): e1008460. 31 October 2019

Genetics of intellectual disability in consanguineous families.
Hu, H. and Kahrizi, K. and Musante, L. and Fattahi, Z. and Herwig, R. and Hosseini, M. and Oppitz, C. and Abedini, S.S. and Suckow, V. and Larti, F. and Beheshtian, M. and Lipkowitz, B. and Akhtarkhavari, T. and Mehvari, S. and Otto, S. and Mohseni, M. and Arzhangi, S. and Jamali, P. and Mojahedi, F. and Taghdiri, M. and Papari, E. and Soltani Banavandi, M.J. and Akbari, S. and Tonekaboni, S.H. and Dehghani, H. and Ebrahimpour, M.R. and Bader, I. and Davarnia, B. and Cohen, M. and Khodaei, H. and Albrecht, B. and Azimi, S. and Zirn, B. and Bastami, M. and Wieczorek, D. and Bahrami, G. and Keleman, K. and Vahid, L.N. and Tzschach, A. and Gärtner, J. and Gillessen-Kaesbach, G. and Varaghchi, J.R. and Timmermann, B. and Pourfatemi, F. and Jankhah, A. and Chen, W. and Nikuei, P. and Kalscheuer, V.M. and Oladnabi, M. and Wienker, T.F. and Ropers, H.H. and Najmabadi, H.
Molecular Psychiatry 24 (7): 1027-1039. July 2019

The histone demethylase PHF8 facilitates alternative splicing of the histocompatibility antigen HLA-G.
Leisegang, M.S. and Gu, L. and Preussner, J. and Günther, S. and Hitzel, J. and Ratiu, C. and Weigert, A. and Chen, W. and Schwarz, E.C. and Looso, M. and Fork, C. and Brandes, R.P.
FEBS Letters 593 (5): 487-498. March 2019

Splicing factor Rbm10 facilitates heterochromatin assembly in fission yeast.
Weigt, M. and Gao, Q. and Ban, H. and He, H. and Mastrobuoni, G. and Kempa, S. and Chen, W. and Li, F.
bioRxiv : 518936. 11 January 2019

An integrated understanding of the molecular mechanisms how adipose tissue metabolism affects long-term body weight maintenance.
Mai, K. and Li, L. and Wiegand, S. and Brachs, M. and Leupelt, V. and Ernert, A. and Kühnen, P. and Hübner, N. and Robinson, P. and Chen, W. and Krude, H. and Spranger, J.
Diabetes 68 (1): 57-65. 1 January 2019

Identification and regulation of the long non-coding RNA Heat2 in heart failure.
Boeckel, J.N. and Perret, M.F. and Glaser, S.F. and Seeger, T. and Heumüller, A.W. and Chen, W. and John, D. and Kokot, K.E. and Katus, H.A. and Haas, J. and Lackner, M.K. and Kayvanpour, E. and Grabe, N. and Dieterich, C. and von Haehling, S. and Ebner, N. and Hünecke, S. and Leuschner, F. and Fichtlscherer, S. and Meder, B. and Zeiher, A.M. and Dimmeler, S. and Keller, T.
Journal of Molecular and Cellular Cardiology 126 : 13-22. January 2019

2018

The IκB kinase complex is a regulator of mRNA stability.
Mikuda, N. and Kolesnichenko, M. and Beaudette, P. and Popp, O. and Uyar, B. and Sun, W. and Tufan, A.B. and Perder, B. and Akalin, A. and Chen, W. and Mertins, P. and Dittmar, G. and Hinz, M. and Scheidereit, C.
EMBO Journal 37 (24): e98658. 14 December 2018

The dynamic proteome of influenza A virus infection identifies M segment splicing as a host range determinant.
Bogdanow, B. and Eichelbaum, K. and Sadewasser, A. and Wang, X. and Husic, I. and Paki, K. and Hergeselle, M. and Vetter, B. and Hou, J. and Chen, W. and Wiebusch, L. and Meyer, I.M. and Wolff, T. and Selbach, M.
bioRxiv : 438176. 8 October 2018

Degradation and remobilization of endogenous retroviruses by recombination during the earliest stages of a germ-line invasion.
Löber, U. and Hobbs, M. and Dayaram, A. and Tsangaras, K. and Jones, K. and Alquezar-Planas, D.E. and Ishida, Y. and Meers, J. and Mayer, J. and Quedenau, C. and Chen, W. and Johnson, R.N. and Timms, P. and Young, P.R. and Roca, A.L. and Greenwood, A.D.
Proceedings of the National Academy of Sciences of the United States of America 115 (34): 8609-8614. 21 August 2018

Pervasive allele-specific regulation on RNA decay in hybrid mice.
Sun, W. and Gao, Q. and Schaefke, B. and Hu, Y. and Chen, W.
Life Science Alliance 1 (2): e201800052. May 2018

Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control.
Yang, J.Y. and Deng, X.Y. and Li, Y.S. and Ma, X.C. and Feng, J.X. and Yu, B. and Chen, Y. and Luo, Y.L. and Wang, X. and Chen, M.L. and Fang, Z.X. and Zheng, F.X. and Li, Y.P. and Zhong, Q. and Kang, T.B. and Song, L.B. and Xu, R.H. and Zeng, M.S. and Chen, W. and Zhang, H. and Xie, W. and Gao, S.
Nature Communications 9 (1): 1165. 21 March 2018

Long noncoding RNA lISPR1 is required for S1P signaling and endothelial cell function.
Josipovic, I. and Pflueger, B. and Fork, C. and Vasconez, A.E. and Oo, J.A. and Hitzel, J. and Seredinski, S. and Gamen, E. and Heringdorf, D.M.Z. and Chen, W. and Looso, M. and Pullamsetti, S.S. and Brandes, R.P. and Leisegang, M.S.
Journal of Molecular and Cellular Cardiology 116 : 57-68. March 2018

Metabolic labeling of newly synthesized RNA with 4sU to in parallel assess RNA transcription and decay.
Sun, W. and Chen, W.
Methods in Molecular Biology 1720 : 25-34. 2018

2017

Polylox barcoding reveals haematopoietic stem cell fates realized in vivo.
Pei, W. and Feyerabend, T.B. and Rössler, J. and Wang, X. and Postrach, D. and Busch, K. and Rode, I. and Klapproth, K. and Dietlein, N. and Quedenau, C. and Chen, W. and Sauer, S. and Wolf, S. and Höfer, T. and Rodewald, H.Re.
Nature 548 (7668): 456-460. 24 August 2017

Identification and functional characterization of hypoxia-induced endoplasmic reticulum stress regulating lncRNA (HypERlnc) in pericytes.
Bischoff, F.C. and Werner, A. and John, D. and Boeckel, J.-N. and Melissari, M.-T. and Grote, P. and Glaser, S.F. and Demolli, S. and Uchida, S. and Michalik, K.M. and Meder, B. and Katus, H.A. and Haas, J. and Chen, W. and Pullamsetti, S.S. and Seeger, W. and Zeiher, A.M. and Dimmeler, S. and Zehendner, C.M.
Circulation Research 121 (4): 368-375. 4 August 2017

Myeloid-derived suppressor cells promote B-cell production of IgA in a TNFR2-dependent manner.
Xu, X. and Meng, Q. and Erben, U. and Wang, P. and Glauben, R. and Kuehl, A.A. and Wu, H. and Ma, C.W. and Hu, M. and Wang, Y. and Sun, W. and Jia, J. and Wu, X. and Chen, W. and Siegmund, B. and Qin, Z.
Cellular and Molecular Immunology 14 (7): 597-606. July 2017

Muscle-relevant genes marked by stable H3K4me2/3 profiles and enriched MyoD binding during myogenic differentiation.
Cui, H. and Bansal, V. and Grunert, M. and Malecova, B. and Dall Agnese, A. and Latella, L. and Gatto, S. and Ryan, T. and Schulz, K. and Chen, W. and Dorn, C. and Puri, P.L. and Sperling, S.R.
PLoS ONE 12 (6): e0179464. 13 June 2017

Identification of the elementary structural units of the DNA damage response.
Natale, F. and Rapp, A. and Yu, W. and Maiser, A. and Harz, H. and Scholl, A. and Grulich, S. and Anton, T. and Hoerl, D. and Chen, W. and Durante, M. and Taucher-Scholz, G. and Leonhardt, H. and Cardoso, M.C.
Nature Communications 8 : 15760. 12 June 2017

Somatic mutations and progressive monosomy modify SAMD9-related phenotypes in humans.
Buonocore, F. and Kuehnen, P. and Suntharalingham, J.P. and Del Valle, I. and Digweed, M. and Stachelscheid, H. and Khajavi, N. and Didi, M. and Brady, A.F. and Blankenstein, O. and Procter, A.M. and Dimitri, P. and Wales, J.K.H. and Ghirri, P. and Knoebl, D. and Strahm, B. and Erlacher, M. and Wlodarski, M.W. and Chen, W. and Kokai, G.K. and Anderson, G. and Morrogh, D. and Moulding, D.A. and McKee, S. A. and Niemeyer, C.M. and Grueters, A. and Achermann, J.C.
Journal of Clinical Investigation 127 (5): 1700-1713. 1 May 2017

Pontine tegmental cap dysplasia in an extremely preterm infant and review of the literature.
Picker-Minh, S. and Hartenstein, S. and Proquitte, H. and Froehler, S. and Raile, V. and Kraemer, N. and Apeshiotis, S. and Leipoldt, M. and Kalache, K.D. and Morris-Rosendahl, D. and Boltshauser, E. and Chen, W. and Kaindl, A.M.
Journal of Child Neurology 32 (3): 334-340. March 2017

Combining transcription factor binding affinities with open-chromatin data for accurate gene expression prediction.
Schmidt, F. and Gasparoni, N. and Gasparoni, G. and Gianmoena, K. and Cadenas, C. and Polansky, J.K. and Ebert, P. and Nordstroem, K. and Barann, M. and Sinha, A. and Froehler, S. and Xiong, J. and Dehghani Amirabad, A. and Behjati Ardakani, F. and Hutter, B. and Zipprich, G. and Felder, B. and Eils, J. and Brors, B. and Chen, W. and Hengstler, J.G. and Hamann, A. and Lengauer, T. and Rosenstiel, P. and Walter, J. and Schulz, M.H.
Nucleic Acids Research 45 (1): 54-66. 9 January 2017

2016

Global analysis of regulatory divergence in the evolution of mouse alternative polyadenylation.
Xiao, M.S. and Zhang, B. and Li, Y.S. and Gao, Q. and Sun, W. and Chen, W.
Molecular Systems Biology 12 (12): 890. 8 December 2016

Epigenomic profiling of human CD4(+) T cells supports a linear differentiation model and highlights molecular regulators of memory development.
Durek, P. and Nordström, K. and Gasparoni, G. and Salhab, A. and Kressler, C. and de Almeida, M. and Bassler, K. and Ulas, T. and Schmidt, F. and Xiong, J. and Glažar, P. and Klironomos, F. and Sinha, A. and Kinkley, S. and Yang, X. and Arrigoni, L. and Amirabad, A.. and Ardakani, F.B. and Feuerbach, L. and Gorka, O. and Ebert, P. and Müller, F. and Li, N. and Frischbutter, S. and Schlickeiser, S. and Cendon, C. and Fröhler, S. and Felder, B. and Gasparoni, N. and Imbusch, C.D. and Hutter, B. and Zipprich, G. and Tauchmann, Y. and Reinke, S. and Wassilew, G. and Hoffmann, U. and Richter, A.S. and Sieverling, L. and Chang, H.D. and Syrbe, U. and Kalus, U. and Eils, J. and Brors, B. and Manke, T. and Ruland, J. and Lengauer, T. and Rajewsky, N. and Chen, W. and Dong, J. and Sawitzki, B. and Chung, H.R. and Rosenstiel, P. and Schulz, M.H. and Schultze, J.L. and Radbruch, A. and Walter, J. and Hamann, A. and Polansky, J.K.
Immunity 45 (5): 1148-1161. 15 November 2016

Kinetic analysis of protein stability reveals age-dependent degradation.
McShane, E. and Sin, C. and Zauber, H. and Wells, J.N. and Donnelly, N. and Wang, X. and Hou, J. and Chen, W. and Storchova, Z. and Marsh, J.A. and Valleriani, A. and Selbach, M.
Cell 167 (3): 803-815. 20 October 2016

Combining transcription factor binding affinities with open-chromatin data for accurate gene expression prediction.
Schmidt, F. and Gasparoni, N. and Gasparoni, G. and Gianmoena, K. and Cadenas, C. and Polansky, J.K. and Ebert, P. and Nordstroem, K. and Barann, M. and Sinha, A. and Froehler, S. and Xiong, J. and Amirabad, A.D. and Ardakani, F.B. and Hutter, B. and Zipprich, G. and Felder, B. and Eils, J. and Brors, B. and Chen, W. and Hengstler, J.G. and Hamann, A. and Lengauer, T. and Rosenstiel, P. and Walter, J. and Schulz, M.H.
bioRxiv : 081935. 19 October 2016

Imprinting of skin/inflammation homing in CD4+ T cells is controlled by DNA methylation within the fucosyltransferase 7 gene.
Pink, M. and Ratsch, B.A. and Mardahl, M. and Durek, P. and Polansky, J.K. and Karl, M. and Baumgrass, R. and Wallner, S. and Cadenas, C. and Gianmoena, K. and Floess, S. and Chen, W. and Nordstroem, K. and Tierling, S. and Olek, S. and Walter, J. and Hamann, A. and Syrbe, U.
Journal of Immunology 197 (8): 3406-3414. 15 October 2016

Comparative DNA methylation and gene expression analysis identifies novel genes for structural congenital heart diseases.
Grunert, M. and Dorn, C. and Cui, H. and Dunkel, I. and Schulz, K. and Schoenhals, S. and Sun, W. and Berger, F. and Chen, W. and Sperling, S.R.
Cardiovascular Research 112 (1): 464-477. 1 October 2016

Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation.
Stellos, K. and Gatsiou, A. and Stamatelopoulos, K. and Perisic Matic, L. and John, D. and Lunella, F.F. and Jae, N. and Rossbach, O. and Amrhein, C. and Sigala, F. and Boon, R.A. and Fuertig, B. and Manavski, Y. and You, X. and Uchida, S. and Keller, T. and Boeckel, J.N. and Franco-Cereceda, A. and Maegdefessel, L. and Chen, W. and Schwalbe, H. and Bindereif, A. and Eriksson, P. and Hedin, U. and Zeiher, A.M. and Dimmeler, S.
Nature Medicine 22 (10): 1140-1150. October 2016

Comprehensive small RNA-Seq of adeno-associated virus (AAV)-infected human cells detects patterns of novel, non-coding AAV RNAs in the absence of cellular miRNA regulation.
Stutika, C. and Mietzsch, M. and Gogol-Doering, A. and Weger, S. and Sohn, M. and Chen, W. and Heilbronn, R.
PLoS ONE 11 (9): e0161454. 9 September 2016

ANGIOGENES: knowledge database for protein-coding and noncoding RNA genes in endothelial cells.
Mueller, R. and Weirick, T. and John, D. and Militello, G. and Chen, W. and Dimmeler, S. and Uchida, S.
Scientific Reports 6 : 32475. 1 September 2016

Circular RNAs in brain and other tissues: a functional enigma.
Chen, W. and Schuman, E.
Trends in Neurosciences 39 (9): 597-604. September 2016

reChIP-seq reveals widespread bivalency of H3K4me3 and H3K27me3 in CD4(+) memory T cells.
Kinkley, S. and Helmuth, J. and Polansky, J.K. and Dunkel, I. and Gasparoni, G. and Froehler, S. and Chen, W. and Walter, J. and Hamann, A. and Chung, H.R.
Nature Communications 7 : 12514. 17 August 2016

Characterization of a single genomic locus encoding the clustered protocadherin receptor diversity in Xenopus tropicalis.
Etlioglu, H.E. and Sun, W. and Huang, Z. and Chen, W. and Schmucker, D.
G3 : Genes Genomes Genetics 6 (8): 2309-2318. 1 August 2016

Epigenetic dynamics of monocyte-to-macrophage differentiation.
Wallner, S. and Schroeder, C. and Leitão, E. and Berulava, T. and Haak, C. and Beißer, D. and Rahmann, S. and Richter, A.S. and Manke, T. and Bönisch, U. and Arrigoni, L. and Fröhler, S. and Klironomos, F. and Chen, W. and Rajewsky, N. and Müller, F. and Ebert, P. and Lengauer, T. and Barann, M. and Rosenstiel, P. and Gasparoni, G. and Nordström, K. and Walter, J. and Brors, B. and Zipprich, G. and Felder, B. and Klein-Hitpass, L. and Attenberger, C. and Schmitz, G. and Horsthemke, B.
Epigenetics & Chromatin 9 : 33. 29 July 2016

Pervasive isoform-specific translational regulation via alternative transcription start sites in mammals.
Wang, X. and Hou, J. and Quedenau, C. and Chen, W.
Molecular Systems Biology 12 (7): 875. 18 July 2016

Data integration for identification of important transcription factors of STAT6-mediated cell fate decisions.
Jargosch, M. and Kroeger, S. and Gralinska, E. and Klotz, U. and Fang, Z. and Chen, W. and Leser, U. and Selbig, J. and Groth, D. and Baumgrass, R.
Genetics and Molecular Research 15 (2): gmr.15028493. 24 June 2016

ANP system activity predicts variability of fat mass reduction and insulin sensitivity during weight loss.
Brachs, M. and Wiegand, S. and Leupelt, V. and Ernert, A. and Kintscher, U. and Jumpertz von Schwarzenberg, R. and Decker, A.M. and Bobbert, T. and Hübner, N. and Chen, W. and Krude, H. and Spranger, J. and Mai, K.
Metabolism 65 (6): 935-943. June 2016

Genetic causes of MCPH in consanguineous Pakistani families.
Kraemer, N. and Picker-Minh, S. and Abbasi, A.A. and Froehler, S. and Ninnemann, O. and Khan, M.N. and Ali, G. and Chen, W. and Kaindl, A.M.
Clinical Genetics 89 (6): 744-745. June 2016

A germline chromothripsis event stably segregating in 11 individuals through three generations.
Bertelsen, B. and Nazaryan-Petersen, L. and Sun, W. and Mehrjouy, M.M. and Xie, G. and Chen, W. and Hjermind, L.E. and Taschner, P.E.M. and Tuemer, Z.
Genetics in Medicine 18 (5): 494-500. May 2016

Genome-wide profiling reveals remarkable parallels between insertion site selection properties of the MLV retrovirus and the piggyBac transposon in primary human CD4(+) T cells.
Gogol-Döring, A. and Ammar, I. and Gupta, S. and Bunse, M. and Miskey, C. and Chen, W. and Uckert, W. and Schulz, T.F. and Izsvák, Z. and Ivics, Z.
Molecular Therapy 24 (3): 592-606. March 2016

A comprehensive RNA sequencing analysis of the adeno-associated virus (AAV) type 2 transcriptome reveals novel AAV transcripts, splice variants, and derived proteins.
Stutika, C. and Gogol-Doering, A. and Botschen, L. and Mietzsch, M. and Weger, S. and Feldkamp, M. and Chen, W. and Heilbronn, R.
Journal of Virology 90 (3): 1278-1289. February 2016

X-exome sequencing of 405 unresolved families identifies seven novel intellectual disability genes.
Hu, H. and Haas, S.A. and Chelly, J. and Van Esch, H. and Raynaud, M. and de Brouwer, A.P.M. and Weinert, S. and Froyen, G. and Frints, S.G.M. and Laumonnier, F. and Zemojtel, T. and Love, M.I. and Richard, H. and Emde, A.K. and Bienek, M. and Jensen, C. and Hambrock, M. and Fischer, U. and Langnick, C. and Feldkamp, M. and Wissink-Lindhout, W. and Lebrun, N. and Castelnau, L. and Rucci, J. and Montjean, R. and Dorseuil, O. and Billuart, P. and Stuhlmann, T. and Shaw, M. and Corbett, M.A. and Gardner, A. and Willis-Owen, S. and Tan, C. and Friend, K.L. and Belet, S. and van Roozendaal, K.E.P. and Jimenez-Pocquet, M. and Moizard, M.P. and Ronce, N. and Sun, R. and O'Keeffe, S. and Chenna, R. and van Bömmel, A. and Goeke, J. and Hackett, A. and Field, M. and Christie, L. and Boyle, J. and Haan, E. and Nelson, J. and Turner, G. and Baynam, G. and Gillessen-Kaesbach, G. and Mueller, U. and Steinberger, D. and Budny, B. and Badura-Stronka, M. and Latos-Bieleńska, A. and Ousager, L.B. and Wieacker, P. and Rodríguez Criado, G. and Bondeson, M.L. and Annerén, G. and Dufke, A. and Cohen, M. and Van Maldergem, L. and Vincent-Delorme, C. and Echenne, B. and Simon-Bouy, B. and Kleefstra, T. and Willemsen, M. and Fryns, J.P. and Devriendt, K. and Ullmann, R. and Vingron, M. and Wrogemann, K. and Wienker, T.F. and Tzschach, A. and van Bokhoven, H. and Gecz, J. and Jentsch, T.J. and Chen, W. and Ropers, H.H. and Kalscheuer, V.M.
Molecular Psychiatry 21 (1): 133-148. January 2016

2015

Multiple sources of infection and potential endemic characteristics of the large outbreak of dengue in Guangdong in 2014.
Shen, S.Q. and Wei, H.X. and Fu, Y.H. and Zhang, H. and Mo, Q.Y. and Wang, X.J. and Deng, S.Q. and Zhao, W. and Liu, Y. and Feng, X.S. and Chen, W. and Peng, H.J.
Scientific Reports 5 : 16913. 23 November 2015

A grainyhead-like 2/Ovo-like 2 pathway regulates renal epithelial barrier function and lumen expansion.
Aue, A. and Hinze, C. and Walentin, K. and Ruffert, J. and Yurtdas, Y. and Werth, M. and Chen, W. and Rabien, A. and Kilic, E. and Schulzke, J.D. and Schumann, M. and Schmidt-Ott, K.M.
Journal of the American Society of Nephrology 26 (11): 2704-2715. November 2015

Identification and characterization of hypoxia-regulated endothelial circular RNA.
Boeckel, J.N. and Jae, N. and Heumueller, A.W. and Chen, W. and Boon, R.A. and Stellos, K. and Zeiher, A.M. and John, D. and Uchida, S. and Dimmeler, S.
Circulation Research 117 (10): 884-890. 23 October 2015

Extensive allele-specific translational regulation in hybrid mice.
Hou, J. and Wang, X. and McShane, E. and Zauber, H. and Sun, W. and Selbach, M. and Chen, W.
Molecular Systems Biology 11 (8): 825. 7 August 2015

Discovering the mechanisms underlying serotonin (5-HT)2A and 5-HT2C receptor regulation following nicotine withdrawal in rats.
Zaniewska, M. and Alenina, N. and Wydra, K. and Fröhler, S. and Kuśmider, M. and McCreary, A.C. and Chen, W. and Bader, M. and Filip, M.
Journal of Neurochemistry 134 (4): 704-716. August 2015

Predominant contribution of cis-regulatory divergence in the evolution of mouse alternative splicing.
Gao, Q. and Sun, W. and Ballegeer, M. and Libert, C. and Chen, W.
Molecular Systems Biology 11 (7): 816. 1 July 2015

Insm1 cooperates with Neurod1 and Foxa2 to maintain mature pancreatic β-cell function.
Jia, S. and Ivanov, A. and Blasevic, D. and Müller, T. and Purfürst, B. and Sun, W. and Chen, W. and Poy, M.N. and Rajewsky, N. and Birchmeier, C.
EMBO Journal 34 (10): 1417-1433. 12 May 2015

Identification of a new genomic hot spot of evolutionary diversification of protein function.
Winkelmann, A. and You, X. and Gruenewald, N. and Haeussler, U. and Krestel, H. and Haas, C.A. and Schwarz, G. and Chen, W. and Meier, J.C.
PLoS ONE 10 (5): e0125413. 8 May 2015

An oncogenic role for alternative NF-κB signaling in DLBCL revealed upon deregulated BCL6 expression.
Zhang, B. and Calado, D.P. and Wang, Z. and Froehler, S. and Koechert, K. and Qian, Y. and Koralov, S.B. and Schmidt-Supprian, M. and Sasaki, Y. and Unitt, C. and Rodig, S. and Chen, W. and Dalla-Favera, R. and Alt, F.W. and Pasqualucci, L. and Rajewsky, K.
Cell Reports 11 (5): 715-726. 5 May 2015

Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity.
You, X. and Vlatkovic, I. and Babic, A. and Will, T. and Epstein, I. and Tushev, G. and Akbalik, G. and Wang, M. and Glock, C. and Quedenau, C. and Wang, X. and Hou, J. and Liu, H. and Sun, W. and Sambandan, S. and Chen, T. and Schuman, E.M. and Chen, W.
Nature Neuroscience 18 (4): 603-610. April 2015

miR-148a is upregulated by Twist1 and T-bet and promotes Th1-cell survival by regulating the proapoptotic gene Bim.
Haftmann, C. and Stittrich, A.B. and Zimmermann, J. and Fang, Z. and Hradilkova, K. and Bardua, M. and Westendorf, K. and Heinz, G.A. and Riedel, R. and Siede, J. and Lehmann, K. and Weinberger, E.E. and Zimmel, D. and Lauer, U. and Häupl, T. and Sieper, J. and Backhaus, M. and Neumann, C. and Hoffmann, U. and Porstner, M. and Chen, W. and Grün, J.R. and Baumgrass, R. and Matz, M. and Löhning, M. and Scheffold, A. and Wittmann, J. and Chang, H.D. and Rajewsky, N. and Jäck, H.M. and Radbruch, A. and Mashreghi, M.F.
European Journal of Immunology 45 (4): 1192-1205. April 2015

A t(3;9)(q25.1;q34.3) translocation leading to OLFM1 fusion transcripts in Gilles de la Tourette syndrome, OCD and ADHD.
Bertelsen, B. and Melchior, L. and Jensen, L.R. and Groth, C. and Nazaryan, L. and Debes, N.M. and Skov, L. and Xie, G. and Sun, W. and Brondum-Nielsen, K. and Kuss, A.W. and Chen, W. and Tuemer, Z.
Psychiatry Research 225 (3): 268-275. 28 February 2015

Glioma-associated microglia/macrophages display an expression profile different from M1 and M2 polarization and highly express Gpnmb and Spp1.
Szulzewsky, F. and Pelz, A. and Feng, X. and Synowitz, M. and Markovic, D. and Langmann, T. and Holtman, I.R. and Wang, X. and Eggen, B.J.L. and Boddeke, H.W.G.M. and Hambardzumyan, D. and Wolf, S.A. and Kettenmann, H.
PLoS ONE 10 (2): e0116644. 6 February 2015

Laminar shear stress inhibits endothelial cell metabolism via KLF2-mediated repression of PFKFB3.
Doddaballapur, A. and Michalik, K.M. and Manavski, Y. and Lucas, T. and Houtkooper, R.H. and You, X. and Chen, W. and Zeiher, A.M. and Potente, M. and Dimmeler, S. and Boon, R.A.
Arteriosclerosis Thrombosis and Vascular Biology 35 (1): 137-145. January 2015

2014

Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells.
Wang, J. and Xie, G. and Singh, M. and Ghanbarian, A.T. and Raskó, T. and Szvetnik, A. and Cai, H. and Besser, D. and Prigione, A. and Fuchs, N.V. and Schumann, G.G. and Chen, W. and Lorincz, M.C. and Ivics, Z. and Hurst, L.D. and Izsvák, Z.
Nature 516 (7531): 405-409. 18 December 2014

Whole genome sequencing and methylome analysis of the wild guinea pig.
Weyrich, A. and Schuellermann, T. and Heeger, F. and Jeschek, M. and Mazzoni, C.J. and Chen, W. and Schumann, K. and Fickel, J.
BMC Genomics 15 (1): 1036. 28 November 2014

Combined immunodeficiency develops with age in immunodeficiency-centromeric instability-facial anomalies syndrome 2 (ICF2).
von Bernuth, H. and Ravindran, E. and Du, H. and Froehler, S. and Strehl, K. and Kraemer, N. and Issa-Jahns, L. and Amulic, B. and Ninnemann, O. and Xiao, M.S. and Eirich, K. and Koelsch, U. and Hauptmann, K. and John, R. and Schindler, D. and Wahn, V. and Chen, W. and Kaindl, A.M.
Orphanet Journal of Rare Diseases 9 (1): 116. 21 October 2014

Identification of differentially expressed long noncoding RNAs in bladder cancer.
Peter, S. and Borkowska, E. and Drayton, R.M. and Rakhit, C.P. and Noon, A.P. and Chen, W. and Catto, J.W.F.
Clinical Cancer Research 20 (20): 5311-5321. 15 October 2014

Quantitative profiling of Drosophila melanogaster Dscam1 isoforms reveals no changes in splicing after bacterial exposure.
Armitage, S.A.O. and Sun, W. and You, X. and Kurtz, J. and Schmucker, D. and Chen, W.
PLoS ONE 9 (10): e108660. 13 October 2014

Adeno-associated virus type 2 wild-type and vector-mediated genomic integration profiles of human diploid fibroblasts analyzed by third-generation PacBio DNA sequencing.
Hueser, D. and Gogol-Doering, A. and Chen, W. and Heilbronn, R.
Journal of Virology 88 (19): 11253-11263. 1 October 2014

Genome-wide analysis of trans-splicing in the nematode Pristionchus pacificus unravels conserved gene functions for germline and dauer development in divergent operons.
Sinha, A. and Langnick, C. and Sommer, R.J. and Dieterich, C.
RNA 20 (9): 1386-1397. September 2014

Natural variation of histone modification and its impact on gene expression in the rat genome.
Rintisch, C. and Heinig, M. and Bauerfeind, A. and Schafer, S. and Mieth, C. and Patone, G. and Hummel, O. and Chen, W. and Cook, S. and Cuppen, E. and Colomé-Tatché, M. and Johannes, F. and Jansen, R.C. and Neil, H. and Werner, M. and Pravenec, M. and Vingron, M. and Hubner, N.
Genome Research 24 (6): 942-953. June 2014

MOV10 is a 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs.
Gregersen, L.H. and Schueler, M. and Munschauer, M. and Mastrobuoni, G. and Chen, W. and Kempa, S. and Dieterich, C. and Landthaler, M.
Molecular Cell 54 (4): 573-585. 22 May 2014

Polar bear encephalitis: establishment of a comprehensive next-generation pathogen analysis pipeline for captive and free-living wildlife.
Szentiks, C.A. and Tsangaras, K. and Abendroth, B. and Scheuch, M. and Stenglein, M.D. and Wohlsein, P. and Heeger, F. and Hoeveler, R. and Chen, W. and Sun, W. and Damiani, A. and Nikolin, V. and Gruber, A.D. and Grobbel, M. and Kalthoff, D. and Hoeper, D. and Czirjak, G.A. and DeRisi, J. and Mazzoni, C.J. and Schuele, A. and Aue, A. and East, M.L. and Hofer, H. and Beer, M. and Osterrieder, N. and Greenwood, A.D.
Journal of Comparative Pathology 150 (4): 474-488. May 2014

Exome sequencing helped the fine diagnosis of two siblings afflicted with atypical Timothy syndrome (TS2).
Froehler, S. and Kieslich, M. and Langnick, C. and Feldkamp, M. and Opgen-Rhein, B. and Berger, F. and Will, J.C. and Chen, W.
BMC Medical Genetics 15 (1): 48. 29 April 2014

Long noncoding RNA MALAT1 regulates endothelial cell function and vessel growth.
Michalik, K.M. and You, X. and Manavski, Y. and Doddaballapur, A. and Zoernig, M. and Braun, T. and John, D. and Ponomareva, Y. and Chen, W. and Uchida, S. and Boon, R.A. and Dimmeler, S.
Circulation Research 114 (9): 1389-1397. 25 April 2014

A 3-base pair deletion, c.9711_9713del, in DMD results in intellectual disability without muscular dystrophy.
de Brouwer, A.P.M. and Nabuurs, S.B. and Verhaart, I.E.C. and Oudakker, A.R. and Hordijk, R. and Yntema, H.G. and Hordijk-Hos, J.M. and Voesenek, K. and de Vries, B.B.A. and van Essen, T. and Chen, W. and Hu, H. and Chelly, J. and den Dunnen, J.T. and Kalscheuer, V.M. and Aartsma-Rus, A.M. and Hamel, B.C.J. and van Bokhoven, H. and Kleefstra, T.
European Journal of Human Genetics 22 (4): 480-485. April 2014

Differential protein occupancy profiling of the mRNA transcriptome.
Schueler, M. and Munschauer, M. and Gregersen, L.H. and Finzel, A. and Loewer, A. and Chen, W. and Landthaler, M. and Dieterich, C.
Genome Biology 15 (1): R15. 13 January 2014

Design and analysis of Bar-seq experiments.
Robinson, D.G. and Chen, W. and Storey, J.D. and Gresham, D.
G3 4 (1): 11-18. 10 January 2014

Argonaute2 mediates compensatory expansion of the pancreatic β cell.
Tattikota, S.G. and Rathjen, T. and McAnulty, S.J. and Wessels, H.H. and Akerman, I. and van de Bunt, M. and Hausser, J. and Esguerra, J.L.S. and Musahl, A. and Pandey, A.K. and You, X. and Chen, W. and Herrera, P.L. and Johnson, P.R. and O'Carroll, D. and Eliasson, L. and Zavolan, M. and Gloyn, A.L. and Ferrer, J. and Shalom-Feuerstein, R. and Aberdam, D. and Poy, M.N.
Cell Metabolism 19 (1): 122-134. 7 January 2014

Identification of PENDRIN (SLC26A4) mutations in patients with congenital hypothyroidism and "apparent" thyroid dysgenesis.
Kuehnen, P. and Turan, S. and Froehler, S. and Gueran, T. and Abali, S. and Biebermann, H. and Bereket, A. and Grueters, A. and Chen, W. and Krude, H.
Journal of Clinical Endocrinology and Metabolism 99 (1): E169-E176. January 2014

2013

Abnormal centrosome and spindle morphology in a patient with autosomal recessive primary microcephaly type 2 due to compound heterozygous WDR62 gene mutations.
Farag, H.G. and Froehler, S. and Oexle, K. and Ravindran, E. and Schindler, D. and Staab, T. and Huebner, A. and Kraemer, N. and Chen, W. and Kaindl, A.M.
Orphanet Journal of Rare Diseases 8 (1): 178. 14 November 2013

Mutually exclusive signaling signatures define the hepatic and pancreatic progenitor cell lineage divergence.
Rodríguez-Seguel, E. and Mah, N. and Naumann, H. and Pongrac, I.M. and Cerdá-Esteban, N. and Fontaine, J.F. and Wang, Y. and Chen, W. and Andrade-Navarro, M.A. and Spagnoli, F.M.
Genes & Development 27 (17): 1932-1946. 1 September 2013

Integrative analysis revealed the molecular mechanism underlying RBM10-mediated splicing regulation.
Wang, Y. and Gogol-Döring, A. and Hu, H. and Fröhler, S. and Ma, Y. and Jens, M. and Maaskola, J. and Murakawa, Y. and Quedenau, C. and Landthaler, M. and Kalscheuer, V. and Wieczorek, D. and Wang, Y. and Hu, Y. and Chen, W.
EMBO Molecular Medicine 5 (9): 1431-1442. September 2013

A novel endogenous betaretrovirus group characterized from polar bears (Ursus maritimus) and giant pandas (Ailuropoda melanoleuca).
Mayer, J. and Tsangaras, K. and Heeger, F. and Avila-Arcos, M. and Stenglein, M.D. and Chen, W. and Sun, W. and Mazzoni, C.J. and Osterrieder, N. and Greenwood, A.D.
Virology 443 (1): 1-10. 15 August 2013

Genome sequencing reveals loci under artificial selection that underlie disease phenotypes in the laboratory rat.
Atanur, S.S. and Diaz, A.G. and Maratou, K. and Sarkis, A. and Rotival, M. and Game, L. and Tschannen, M.R. and Kaisaki, P.J. and Otto, G.W. and John Ma, M.C. and Keane, T.M. and Hummel, O. and Saar, K. and Chen, W. and Guryev, V. and Gopalakrishnan, K. and Garrett, M.R. and Joe, B. and Citterio, L. and Bianchi, G. and McBride, M. and Dominiczak, A. and Adams, D.J. and Serikawa, T. and Flicek, P. and Cuppen, E. and Hubner, N. and Petretto, E. and Gauguier, D. and Kwitek, A. and Jacob, H. and Aitman, T.J.
Cell 154 (3): 691-703. 1 August 2013

A systematic evaluation of hybridization-based mouse exome capture system.
Gao, Q. and Sun, W. and You, X. and Froehler, S. and Chen, W.
BMC Genomics 14 (1): 492. 21 July 2013

Ultra-deep profiling of alternatively spliced Drosophila Dscam isoforms by circularization-assisted multi-segment sequencing.
Sun, W. and You, X. and Gogol-Doering, A. and He, H. and Kise, Y. and Sohn, M. and Chen, T. and Klebes, A. and Schmucker, D. and Chen, W.
EMBO Journal 32 (14): 2029-2038. 17 July 2013

Mechanisms of in vivo binding site selection of the hematopoietic master transcription factor PU.1.
Pham, T.H. and Minderjahn, J. and Schmidl, C. and Hoffmeister, H. and Schmidhofer, S. and Chen, W. and Laengst, G. and Benner, C. and Rehli, M.
Nucleic Acids Research 41 (13): 6391-6402. July 2013

Argonaute2 regulates the pancreatic β-cell secretome.
Tattikota, S.G. and Sury, M.D. and Rathjen, T. and Wessels, H.H. and Pandey, A.K. and You, X. and Becker, C. and Chen, W. and Selbach, M. and Poy, M.N.
Molecular & Cellular Proteomics 12 (5): 1214-1225. May 2013

Global profiling of miRNAs and the hairpin precursors: insights into miRNA processing and novel miRNA discovery.
Li, N. and You, X. and Chen, T. and Mackowiak, S.D. and Friedlaender, M.R. and Weigt, M. and Du, H. and Gogol-Doering, A. and Chang, Z. and Dieterich, C. and Hu, Y. and Chen, W.
Nucleic Acids Research 41 (6): 3619-3634. 8 February 2013

De novo truncating mutations in ASXL3 are associated with a novel clinical phenotype with similarities to Bohring-Opitz syndrome.
Bainbridge, M.N. and Hu, H. and Muzny, D.M. and Musante, L. and Lupski, J.R. and Graham, B.H. and Chen, W. and Gripp, K.W. and Jenny, K. and Wienker, T.F. and Yang, Y. and Sutton, V.R. and Gibbs, R.A. and Ropers, H.H.
Genome Medicine 5 (2): 11. 5 February 2013

Conserved miRNAs are candidate post-transcriptional regulators of developmental arrest in free-living and parasitic nematodes.
Ahmed, R. and Chang, Z. and Younis, A.E. and Langnick, C. and Li, N. and Chen, W. and Brattig, N. and Dieterich, C.
Genome Biology and Evolution 5 (7): 1246-1260. 2013

Widespread splicing changes in human brain development and aging.
Mazin, P. and Xiong, J. and Liu, X. and Yan, Z. and Zhang, X. and Li, M. and He, L. and Somel, M. and Yuan, Y. and Chen, Y.P.P. and Li, N. and Hu, Y. and Fu, N. and Ning, Z. and Zeng, R. and Yang, H. and Chen, W. and Gelfand, M. and Khaitovich, P.
Molecular Systems Biology 9 : 633. 2013

2012

Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat, S. and Schmidt, A. and Codlin, S. and Chen, W. and Aebersold, R. and Baehler, J.
Cell 151 (3): 671-683. 26 October 2012

Detection for gene-gene co-association via kernel canonical correlation analysis.
Yuan, Z. and Gao, Q. and He, Y. and Zhang, X. and Li, F. and Zhao, J. and Xue, F.
BMC Genetics 13 : 83. 8 October 2012

Retargeting Sleeping Beauty transposon insertions by engineered zinc finger DNA-binding domains.
Voigt, K. and Gogol-Doering, A. and Miskey, C. and Chen, W. and Cathomen, T. and Izsvak, Z. and Ivics, Z.
Molecular Therapy 20 (10): 1852-1862. October 2012

A unilateral negative feedback loop between miR-200 microRNAs and Sox2/E2F3 controls neural progenitor cell-cycle exit and differentiation.
Peng, C. and Li, N. and Ng, Y.K. and Zhang, J. and Meier, F. and Theis, F.J. and Merkenschlager, M. and Chen, W. and Wurst, W. and Prakash, N.
Journal of Neuroscience 32 (38): 13292-13308. 19 September 2012

Retargeting transposon insertions by the adeno-associated virus Rep protein.
Ammar, I. and Gogol-Doering, A. and Miskey, C. and Chen, W. and Cathomen, T. and Izsvak, Z. and Ivics, Z.
Nucleic Acids Research 40 (14): 6693-6712. 1 August 2012

Dynamic epigenetic enhancer signatures reveal key transcription factors associated with monocytic differentiation states.
Pham, T.H. and Benner, C. and Lichtinger, M. and Schwarzfischer, L. and Hu, Y. and Andreesen, R. and Chen, W. and Rehli, M.
Blood 119 (24): e161-e171. 14 June 2012

Gene expression of pluripotency determinants is conserved between mammalian and planarian stem cells.
Onal, P. and Gruen, D. and Adamidi, C. and Rybak, A. and Solana, J. and Mastrobuoni, G. and Wang, Y. and Rahn, H.P. and Chen, W. and Kempa, S. and Ziebold, U. and Rajewsky, N.
EMBO Journal 31 (12): 2755-2769. 27 April 2012

Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques.
Liu, X. and Somel, M. and Tang, L. and Yan, Z. and Jiang, X. and Guo, S. and Yuan, Y.P. and He, L. and Oleksiak, A. and Zhang, Y. and Li, N. and Hu, Y. and Chen, W. and Qiu, Z. and Paeaebo, S. and Khaitovich, P.
Genome Research 22 (4): 611-622. April 2012

Integrated epigenome profiling of repressive histone modifications, DNA methylation and gene expression in normal and malignant urothelial cells.
Dudziec, E. and Gogol-Doering, A. and Cookson, V. and Chen, W. and Catto, J.
PLoS ONE 7 (3): e32750. 7 March 2012

miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades.
Friedlaender, M.R. and Mackowiak, S.D. and Li, N. and Chen, W. and Rajewsky, N.
Nucleic Acids Research 40 (1): 37-52. 1 January 2012

An overview of the analysis of next generation sequencing data.
Gogol-Doering, A. and Chen, W.
Methods in Molecular Biology 802 : 249-257. 2012

2011

MicroRNA-driven developmental remodeling in the brain distinguishes humans from other primates.
Somel, M. and Liu, X. and Tang, L. and Yan, Z. and Hu, H. and Guo, S. and Jiang, X. and Zhang, X. and Xu, G. and Xie, G. and Li, N. and Hu, Y. and Chen, W. and Paeaebo, S. and Khaitovich, P.
PLoS Biology 9 (12): e1001214. December 2011

Deep sequencing reveals 50 novel genes for recessive cognitive disorders.
Najmabadi, H. and Hu, H. and Garshasbi, M. and Zemojtel, T. and Abedini, S.S. and Chen, W. and Hosseini, M. and Behjati, F. and Haas, S. and Jamali, P. and Zecha, A. and Mohseni, M. and Puettmann, L. and Vahid, L.N. and Jensen, C. and Moheb, L.A. and Bienek, M. and Larti, F. and Mueller, I. and Weissmann, R. and Darvish, H. and Wrogemann, K. and Hadavi, V. and Lipkowitz, B. and Esmaeeli-Nieh, S. and Wieczorek, D. and Kariminejad, R. and Firouzabadi, S.G. and Cohen, M. and Fattahi, Z. and Rost, I. and Mojahedi, F. and Hertzberg, C. and Dehghan, A. and Rajab, A. and Banavandi, M.J.S. and Hoffer, J. and Falah, M. and Musante, L. and Kalscheuer, V. and Ullmann, R. and Kuss, A.W. and Tzschach, A. and Kahrizi, K. and Ropers, H.H.
Nature 478 (7367): 57-63. 6 October 2011

MicroRNA expression and regulation in human, chimpanzee, and macaque brains.
Hu, H.Y. and Guo, S. and Xi, J. and Yan, Z. and Fu, N. and Zhang, X. and Menzel, C. and Liang, H. and Yang, H. and Zhao, M. and Zeng, R. and Chen, W. and Paeaebo, S. and Khaitovich, P.
PLoS Genetics 7 (10): e1002327. October 2011

ST3GAL3 mutations impair the development of higher cognitive functions.
Hu, H. and Eggers, K. and Chen, W. and Garshasbi, M. and Motazacker, M.M. and Wrogemann, K. and Kahrizi, K. and Tzschach, A. and Hosseini, M. and Bahman, I. and Hucho, T. and Muehlenhoff, M. and Gerardy-Schahn, R. and Najmabadi, H. and Ropers, H.H. and Kuss, A.W.
American Journal of Human Genetics 89 (3): 407-414. 9 September 2011

Impact of novel sequencing technology on transcriptome analysis.
Chen, W.
European Pharmaceutical Review 16 (4): 61-63. 31 August 2011

Widespread expression of piRNA-like molecules in somatic tissues.
Yan, Z. and Hu, H.Y. and Jiang, X. and Maierhofer, V. and Neb, E. and He, L. and Hu, Y. and Hu, H. and Li, N. and Chen, W. and Khaitovich, P.
Nucleic Acids Research 39 (15): 6596-6607. 1 August 2011

Comparative genomic integration profiling of Sleeping Beauty transposons mobilized with high efficacy from integrase-defective lentiviral vectors in primary human cells.
Moldt, B. and Miskey, C. and Staunstrup, N.H. and Gogol-Doering, A. and Bak, R.O. and Sharma, N. and Mates, L. and Izsvak, Z. and Chen, W. and Ivics, Z. and Mikkelsen, J.G.
Molecular Therapy 19 (8): 1499-1510. August 2011

De novo assembly and validation of planaria transcriptome by massive parallel sequencing and shotgun proteomics.
Adamidi, C. and Wang, Y. and Gruen, D. and Mastrobuoni, G. and You, X. and Tolle, D. and Dodt, M. and Mackowiak, S.D. and Gogol-Doering, A. and Oenal, P. and Rybak, A. and Ross, E. and Alvarado, A.S. and Kempa, S. and Dieterich, C. and Rajewsky, N. and Chen, W.
Genome Research 21 (7): 1193-1200. July 2011

Hybridisation-based resequencing of 17 X-linked intellectual disability genes in 135 patients reveals novel mutations in ATRX, SLC6A8 and PQBP1.
Jensen, L.R. and Chen, W. and Moser, B. and Lipkowitz, B. and Schroeder, C. and Musante, L. and Tzschach, A. and Kalscheuer, V.M. and Meloni, I. and Raynaud, M. and van Esch, H. and Chelly, J. and de Brouwer, A.P. and Hackett, A. and van der Haar, S. and Henn, W. and Gecz, J. and Riess, O. and Bonin, M. and Reinhardt, R. and Ropers, H.H. and Kuss, A.W.
European Journal of Human Genetics 19 (6): 717-720. June 2011

Global quantification of mammalian gene expression control.
Schwanhaeusser, B. and Busse, D. and Li, N. and Dittmar, G. and Schuchhardt, J. and Wolf, J. and Chen, W. and Selbach, M.
Nature 473 (7347): 337-342. 19 May 2011

Two distinct auto-regulatory loops operate at the PU.1 locus in B cells and myeloid cells.
Leddin, M. and Perrod, C. and Hoogenkamp, M. and Ghani, S. and Assi, S. and Heinz, S. and Wilson, N.K. and Follows, G. and Schoenheit, J. and Vockentanz, L. and Mosamam, A. and Chen, W. and Tenen, D.G. and Westhead, D.R. and Goettgens, B. and Bonifer, C. and Rosenbauer, F.
Blood 117 (10): 2827-2838. 10 March 2011

Next generation sequencing in a family with autosomal recessive Kahrizi syndrome (OMIM 612713) reveals a homozygous frameshift mutation in SRD5A3.
Kahrizi, K. and Hu, C.H. and Garshasbi, M. and Abedini, S.S. and Ghadami, S. and Kariminejad, R. and Ullmann, R. and Chen, W. and Ropers, H.H. and Kuss, A.W. and Najmabadi, H. and Tzschach, A.
European Journal of Human Genetics 19 (1): 115-117. January 2011

High-throughput subcellular protein localization using transfected-cell arrays: subcellular protein localization using cell arrays.
Hu, Y. and Janitz, M.
Methods in Molecular Biology 706 : 53-72. 2011

2010

The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes.
Stittrich, A.B. and Haftmann, C. and Sgouroudis, E. and Kuehl, A.A. and Hegazy, A.N. and Panse, I. and Riedel, R. and Flossdorf, M. and Dong, J. and Fuhrmann, F. and Heinz, G.A. and Fang, Z. and Li, N. and Bissels, U. and Hatam, F. and Jahn, A. and Hammoud, B. and Matz, M. and Schulze, F.M. and Baumgrass, R. and Bosio, A. and Mollenkopf, H.J. and Gruen, J. and Thiel, A. and Chen, W. and Hoefer, T. and Loddenkemper, C. and Loehning, M. and Chang, H.D. and Rajewsky, N. and Radbruch, A. and Mashreghi, M.F.
Nature Immunology 11 (11): 1057-1062. November 2010

Genomic analysis of miRNAs in an extreme mammalian hibernator, the Arctic ground squirrel.
Liu, Y. and Hu, W. and Wang, H. and Lu, M. and Shao, C. and Menzel, C. and Yan, Z. and Li, Y. and Zhao, S. and Khaitovich, P. and Liu, M. and Chen, W. and Barnes, B.M. and Yang, J.
Physiological Genomics 42A (1): 39-51. September 2010

MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain.
Somel, M. and Guo, S. and Fu, N. and Yan, Z. and Hu, H.Y. and Xu, Y. and Yuan, Y. and Ning, Z. and Hu, Y. and Menzel, C. and Hu, H. and Lachmann, M. and Zeng, R. and Chen, W. and Khaitovich, P.
Genome Research 20 (9): 1207-1218. September 2010

Intergenic and repeat transcription in human, chimpanzee and macaque brains measured by RNA-Seq.
Xu, A.G. and He, L. and Li, Z. and Xu, Y. and Li, M. and Fu, X. and Yan, Z. and Yuan, Y. and Menzel, C. and Li, N. and Somel, M. and Hu, H. and Chen, W. and Paeaebo, S. and Khaitovich, P.
PLoS Computational Biology 6 (7): e1000843. 1 July 2010

Comprehensive survey of human brain microRNA by deep sequencing.
Shao, N.Y. and Hu, H.Y. and Yan, Z. and Xu, Y. and Hu, H. and Menzel, C. and Li, N. and Chen, W. and Khaitovich, P.
BMC Genomics 11 (1): 409. 30 June 2010

Comparative analysis of transposable element vector systems in human cells.
Grabundzija, I. and Irgang, M. and Mates, L. and Belay, E. and Matrai, J. and Gogol-Doering, A. and Kawakami, K. and Chen, W. and Ruiz, P. and Chuah, M.K. and Vandendriessche, T. and Izsvak, Z. and Ivics, Z.
Molecular Therapy 18 (6): 1200-1209. June 2010

Altered histone acetylation is associated with age-dependent memory impairment in mice.
Peleg, S. and Sananbenesi, F. and Zovoilis, A. and Burkhardt, S. and Bahari-Javan, S. and Agis-Balboa, R.C. and Cota, P. and Wittnam, J.L. and Gogol-Doering, A. and Opitz, L. and Salinas-Riester, G. and Dettenhofer, M. and Kang, H. and Farinelli, L. and Chen, W. and Fischer, A.
Science 328 (5979): 753-756. 7 May 2010

Tumor necrosis factor receptor superfamily member 19 (TNFRSF19) regulates differentiation fate of human mesenchymal (stromal) stem cells through canonical Wnt signaling and C/EBP.
Qiu, W. and Hu, Y. and Andersen, T.E. and Jafari, A. and Li, N. and Chen, W. and Kassem, M.
Journal of Biological Chemistry 285 (19): 14438-14449. 7 May 2010

Breakpoint analysis of balanced chromosome rearrangements by next-generation paired-end sequencing.
Chen, W. and Ullmann, R. and Langnick, C. and Menzel, C. and Wotschofsky, Z. and Hu, H. and Doering, A. and Hu, Y. and Kang, H. and Tzschach, A. and Hoeltzenbein, M. and Neitzel, H. and Markus, S. and Wiedersberg, E. and Kistner, G. and van Ravenswaaij-Arts, C.M. and Kleefstra, T. and Kalscheuer, V.M. and Ropers, H.H.
European Journal of Human Genetics 18 (5): 539-543. May 2010

Deciphering the porcine intestinal microRNA transcriptome.
Sharbati, S. and Friedlaender, M.R. and Sharbati, J. and Hoeke, L. and Chen, W. and Keller, A. and Stahler, P.F. and Rajewsky, N. and Einspanier, R.
BMC Genomics 11 (1): 275. 30 April 2010

Finding optimal sets of enriched regions in chip-seq data.
Gogol-Doering, A. and Chen, W.
Lecture Notes in Informatics P-173 : 113-121. 2010

2009

Mutation screening in 86 known X-linked mental retardation genes by droplet-based multiplex PCR and massive parallel sequencing.
Hu, H. and Wrogemann, K. and Kalscheuer, V. and Tzschach, A. and Richard, H. and Haas, S.A. and Menzel, C. and Bienek, M. and Froyen, G. and Raynaud, M. and Van Bokhoven, H. and Chelly, J. and Ropers, H. and Chen, W.
HUGO Journal 3 (1-4): 41-49. December 2009

Comparative analysis of an experimental subcellular protein localization assay and in silico prediction methods.
Hu, Y. and Lehrach, H. and Janitz, M.
Journal of Molecular Histology 40 (5-6): 343-352. October 2009

Large-scale sorting of C. elegans embryos reveals the dynamics of small RNA expression.
Stoeckius, M. and Maaskola, J. and Colombo, T. and Rahn, H.P. and Friedlaender, M.R. and Li, N. and Chen, W. and Piano, F. and Rajewsky, N.
Nature Methods 6 (10): 745-751. October 2009

Sequence features associated with microRNA strand selection in humans and flies.
Hu, H.Y. and Yan, Z. and Xu, Y. and Hu, H. and Menzel, C. and Zhou, Y.H. and Chen, W. and Khaitovich, P.
BMC Genomics 10 : 413. 4 September 2009

Estimating accuracy of RNA-Seq and microarrays with proteomics.
Fu, X. and Fu, N. and Guo, S. and Yan, Z. and Xu, Y. and Hu, H. and Menzel, C. and Chen, W. and Li, Y. and Zeng, R. and Khaitovich, P.
BMC Genomics 10 : 161. 16 April 2009

2008

A human snoRNA with microRNA-like functions.
Ender, C. and Krek, A. and Friedlaender, M.R. and Beitzinger, M. and Weinmann, L. and Chen, W. and Pfeffer, S. and Rajewsky, N. and Meister, G.
Molecular Cell 32 (4): 519-528. 21 November 2008

High frequency of submicroscopic genomic aberrations detected by tiling path array comparative genome hybridisation in patients with isolated congenital heart disease.
Erdogan, F. and Larsen, L.A. and Zhang, L. and Tuemer, Z. and Tommerup, N. and Chen, W. and Jacobsen, J.R. and Schubert, M. and Jurkatis, J. and Tzschach, A. and Ropers, H.H. and Ullmann, R.
Journal of Medical Genetics 45 (11): 704-709. November 2008

Mapping translocation breakpoints by next-generation sequencing.
Chen, W. and Kalscheuer, V. and Tzschach, A. and Menzel, C. and Ullmann, R. and Schulz, M.H. and Erdogan, F. and Li, N. and Kijas, Z. and Arkesteijn, G. and Pajares, I.L. and Goetz-Sothmann, M. and Heinrich, U. and Rost, I. and Dufke, A. and Grasshoff, U. and Glaeser, B. and Vingron, M. and Ropers, H.H.
Genome Research 18 (7): 1143-1149. July 2008

MicroRNAs in brain function and disease.
Kuss, A.W. and Chen, W.
Current neurology and neuroscience Reports 8 (3): 190-197. May 2008

Discovering microRNAs from deep sequencing data using miRDeep.
Friedlaender, M.R. and Chen, W. and Adamidi, C. and Maaskola, J. and Einspanier, R. and Knespel, S. and Rajewsky, N.
Nature Biotechnology 26 (4): 407-415. April 2008

Epilepsy and mental retardation limited to females: an under-recognized disorder.
Scheffer, I.E. and Turner, S.J. and Dibbens, L.M. and Bayly, M.A. and Friend, K. and Hodgson, B. and Burrows, L. and Shaw, M. and Chen, W. and Ullmann, R. and Ropers, H.H. and Szepetowski, P. and Haan, E. and Mazarib, A. and Afawi, Z. and Neufeld, M.Y. and Andrews, P.I. and Wallace, G. and Kivity, S. and Lev, D. and Lerman-Sagie, T. and Derry, C.P. and Korczyn, A.D. and Gecz, J. and Mulley, J.C. and Berkovic, S.F.
Brain 131 (4): 918-927. April 2008

Comparative genome hybridization suggests a role for NRXN1 and APBA2 in schizophrenia.
Kirov, G. and Gumus, D. and Chen, W. and Norton, N. and Georgieva, L. and Sari, M. and O'Donovan, M.C. and Erdogan, F. and Owen, M.J. and Ropers, H.H. and Ullmann, R.
Human Molecular Genetics 17 (3): 458-465. 1 February 2008

Characterization of interstitial Xp duplications in two families by tiling path array CGH.
Tzschach, A. and Chen, W. and Erdogan, F. and Hoeller, A. and Ropers, H.H. and Castellan, C. and Ullmann, R. and Schinzel, A.
American Journal of Medical Genetics A 146A (2): 197-203. 15 January 2008

2007

Array CGH identifies reciprocal 16p13.1 duplications and deletions that predispose to autism and/or mental retardation.
Ullmann, R. and Turner, G. and Kirchhoff, M. and Chen, W. and Tonge, B. and Rosenberg, C. and Field, M. and Vianna-Morgante, A.M. and Christie, L. and Krepischi-Santos, A.C. and Banna, L. and Brereton, A.V. and Hill, A. and Bisgaard, A.M. and Mueller, I. and Hultschig, C. and Erdogan, F. and Wieczorek, G. and Ropers, H.H.
Human Mutation 28 (7): 674-682. July 2007

Homozygosity mapping in consanguineous families reveals extreme heterogeneity of non-syndromic autosomal recessive mental retardation and identifies 8 novel gene loci.
Najmabadi, H. and Motazacker, M.M. and Garshasbi, M. and Kahrizi, K. and Tzschach, A. and Chen, W. and Behjati, F. and Hadavi, V. and Nieh, S.E. and Abedini, S.S. and Vazifehmand, R. and Firouzabadi, S.G. and Jamali, P. and Falah, M. and Seifati, S.M. and Grueters, A. and Lenzner, S. and Jensen, L.R. and Rueschendorf, F. and Kuss, A.W. and Ropers, H.H.
Human Genetics 121 (1): 43-48. March 2007

Mutation screening of brain-expressed X-chromosomal miRNA genes in 464 patients with nonsyndromic X-linked mental retardation.
Chen, W. and Jensen, L.R. and Gecz, J. and Fryns, J.P. and Moraine, C. and de Brouwer, A. and Chelly, J. and Moser, B. and Ropers, H.H. and Kuss, A.W.
European Journal of Human Genetics 15 (3): 375-378. March 2007

Characterization of a 5.3 Mb deletion in 15q14 by comparative genomic hybridization using a whole genome "tiling path" BAC array in a girl with heart defect, cleft palate, and developmental delay.
Erdogan, F. and Ullmann, R. and Chen, W. and Schubert, M. and Adolph, S. and Hultschig, C. and Kalscheuer, V. and Ropers, H.H. and Spaich, C. and Tzschach, A.
American Journal of Medical Genetics A 143 (2): 172-178. 15 January 2007

X-linked mental retardation: a comprehensive molecular screen of 47 candidate genes from a 7.4 Mb interval in Xp11.
Jensen, L.R. and Lenzner, S. and Moser, B. and Freude, K. and Tzschach, A. and Chen, W. and Fryns, J.P. and Chelly, J. and Turner, G. and Moraine, C. and Hamel, B. and Ropers, H.H. and Kuss, A.W.
European Journal of Human Genetics 15 (1): 68-75. January 2007

2006

Impact of low copy repeats on the generation of balanced and unbalanced chromosomal aberrations in mental retardation.
Erdogan, F. and Chen, W. and Kirchhoff, M. and Kalscheuer, V.M. and Hultschig, C. and Mueller, I. and Schulz, R. and Menzel, C. and Bryndorf, T. and Ropers, H.H. and Ullmann, R.
Cytogenetic and Genome Research 115 (3-4): 247-253. November 2006

A novel X-linked recessive mental retardation syndrome comprising macrocephaly and ciliary dysfunction is allelic to oral-facial-digital type I syndrome.
Budny, B. and Chen, W. and Omran, H. and Fliegauf, M. and Tzschach, A. and Wisniewska, M. and Jensen, L.R. and Raynaud, M. and Shoichet, S.A. and Badura, M. and Lenzner, S. and Latos-Bielenska, A. and Ropers, H.H.
Human Genetics 120 (2): 171-178. September 2006

2005

CGHPRO - a comprehensive data analysis tool for array CGH.
Chen, W. and Erdogan, F. and Ropers, H.H. and Lenzner, S. and Ullmann, R.
BMC Bioinformatics 6 : 85. 2005

2001

Introduction to Go! Poly, a human genome polymorphism database.
Chen, W. and Zhang, G. and Zhang, S.
Chinese Journal of Medical Genetics 18 (6): 482-485. December 2001

Go!Poly: A gene-oriented polymorphism database.
Zhang, G. and Zhang, S. and Chen, W. and Qiu, W. and Wu, H. and Wang, J. and Luo, J. and Gu, X. and Cotton, R.G.
Human Mutation 18 (5): 382-387. November 2001

Discovery of candidate SNP by bioinformatic methods.
Chen, W. and Zhang, G. and Zhang, S.
Hereditas 23 (2): 153-156. 2001