Browse by Journal Title

2020

Combination of copanlisib with cetuximab improves tumor response in cetuximab-resistant patient-derived xenografts of head and neck cancer.
Klinghammer, K. and Politz, O. and Eder, T. and Otto, R. and Raguse, J.D. and Albers, A. and Kaufmann, A. and Tinhofer, I. and Hoffmann, J. and Keller, U. and Keilholz, U.
Oncotarget 11 (41): 3688-3697. 13 October 2020

2018

MYB induces the expression of the oncogenic corepressor SKI in acute myeloid leukemia.
Frech, M. and Teichler, S. and Feld, C. and Bouchard, C. and Berberich, H. and Sorg, K. and Mernberger, M. and Bullinger, L. and Bauer, U.M. and Neubauer, A.
Oncotarget 9 (32): 22423-22435. 27 April 2018

Ectopic expression of transcription factor BATF3 induces B-cell lymphomas in a murine B-cell transplantation model.
Weiser, C. and Petkova, M.V. and Rengstl, B. and Döring, C. and von Laer, D. and Hartmann, S. and Küppers, R. and Hansmann, M.L. and Newrzela, S.
Oncotarget 9 (22): 15942-15951. 23 March 2018

Reactivating TP53 signaling by the novel MDM2 inhibitor DS-3032b as a therapeutic option for high-risk neuroblastoma.
Arnhold, V. and Schmelz, K. and Proba, J. and Winkler, A. and Wünschel, J. and Toedling, J. and Deubzer, H.E. and Künkele, A. and Eggert, A. and Schulte, J.H. and Hundsdoerfer, P.
Oncotarget 9 (2): 2304-2319. 2018

2017

Protein phosphatase 4 regulatory subunit 2 (PPP4R2) is recurrently deleted in acute myeloid leukemia and required for efficient DNA double strand break repair.
Herzig, J.K. and Bullinger, L. and Tasdogan, A. and Zimmermann, P. and Schlegel, M. and Teleanu, V. and Weber, D. and Rücker, F.G. and Paschka, P. and Dolnik, A. and Schneider, E. and Kuchenbauer, F. and Heidel, F.H. and Buske, C. and Döhner, H. and Döhner, K. and Gaidzik, V.I.
Oncotarget 8 (56): 95038-95053. 10 November 2017

Analysis of NPM1 splice variants reveals differential expression patterns of prognostic value in acute myeloid leukemia.
Zajac, M. and Dolnik, A. and Stasiak, G. and Zaleska, J. and Kielbus, M. and Czapinski, J. and Schunn, M. and Correa, S.C. and Glodkowska-Mrowka, E. and Sundaram, R.C. and Jankowska-Lecka, O. and Schlenk, R.F. and Döhner, H. and Döhner, K. and Stepulak, A. and Bullinger, L. and Giannopoulos, K.
Oncotarget 8 (56): 95163-95175. 10 November 2017

Using droplet digital PCR to analyze MYCN and ALK copy number in plasma from patients with neuroblastoma.
Lodrini, M. and Sprüssel, A. and Astrahantseff, K. and Tiburtius, D. and Konschak, R. and Lode, H.N. and Fischer, M. and Keilholz, U. and Eggert, A. and Deubzer, H.E.
Oncotarget 8 (49): 85234-85251. 17 October 2017

Decitabine inhibits T cell proliferation via a novel TET2-dependent mechanism and exerts potent protective effect in mouse auto- and allo-immunity models.
Wang, X. and Wang, J. and Yu, Y. and Ma, T. and Chen, P. and Zhou, B. and Tao, R.
Oncotarget 8 (34): 56802-56815. 22 August 2017

RITA displays anti-tumor activity in medulloblastomas independent of TP53 status.
Gottlieb, A. and Althoff, K. and Grunewald, L. and Thor, T. and Odersky, A. and Schulte, M. and Deubzer, H.E. and Heukamp, L. and Eggert, A. and Schramm, A. and Schulte, J.H. and Künkele, A.
Oncotarget 8 (17): 27882-27891. 25 April 2017

Epigenetic silencing of miR-520c leads to induced S100A4 expression and its mediated colorectal cancer progression.
Mudduluru, G. and Ilm, K. and Fuchs, S. and Stein, U.
Oncotarget 8 (13): 21081-21094. 28 March 2017

Prospective identification of resistance mechanisms to HSP90 inhibition in KRAS mutant cancer cells.
Rouhi, A. and Miller, C. and Grasedieck, S. and Reinhart, S. and Stolze, B. and Döhner, H. and Kuchenbauer, F. and Bullinger, L. and Fröhling, S. and Scholl, C.
Oncotarget 8 (5): 7678-7690. 31 January 2017

The GSK461364 PLK1 inhibitor exhibits strong antitumoral activity in preclinical neuroblastoma models.
Pajtler, K.W. and Sadowski, N. and Ackermann, S. and Althoff, K. and Schönbeck, K. and Batzke, K. and Schäfers, S. and Odersky, A. and Heukamp, L. and Astrahantseff, K. and Künkele, A. and Deubzer, H.E. and Schramm, A. and Sprüssel, A. and Thor, T. and Lindner, S. and Eggert, A. and Fischer, M. and Schulte, J.H.
Oncotarget 8 (4): 6730-6741. 24 January 2017

Targeting tachykinin receptors in neuroblastoma.
Henssen, A.G. and Odersky, A. and Szymansky, A. and Seiler, M. and Althoff, K. and Beckers, A. and Speleman, F. and Schäfers, S. and De Preter, K. and Astrahanseff, K. and Struck, J. and Schramm, A. and Eggert, A. and Bergmann, A. and Schulte, J.H.
Oncotarget 8 (1): 430-443. 3 January 2017

2016

MYCN and HDAC5 transcriptionally repress CD9 to trigger invasion and metastasis in neuroblastoma.
Fabian, J. and Opitz, D. and Althoff, K. and Lodrini, M. and Hero, B. and Volland, R. and Beckers, A. and de Preter, K. and Decock, A. and Patil, N. and Abba, M. and Kopp-Schneider, A. and Astrahantseff, K. and Wünschel, J. and Pfeil, S. and Ercu, M. and Künkele, A. and Hu, J. and Thole, T. and Schweizer, L. and Mechtersheimer, G. and Carter, D. and Cheung, B.B. and Popanda, O. and von Deimling, A. and Koster, J. and Versteeg, R. and Schwab, M. and Marshall, G.M. and Speleman, F. and Erb, U. and Zoeller, M. and Allgayer, H. and Simon, T. and Fischer, M. and Kulozik, A.E. and Eggert, A. and Witt, O. and Schulte, J.H. and Deubzer, H.E.
Oncotarget 7 (41): 66344-66359. 11 October 2016

MACC1 is post-transcriptionally regulated by miR-218 in colorectal cancer.
Ilm, K. and Fuchs, S. and Mudduluru, G. and Stein, U.
Oncotarget 7 (33): 53443-53458. 16 August 2016

The anticancer phytochemical rocaglamide inhibits Rho GTPase activity and cancer cell migration.
Becker, M.S. and Müller, P.M. and Bajorat, J. and Schroeder, A. and Giaisi, M. and Amin, E. and Ahmadian, M.R. and Rocks, O. and Köhler, R. and Krammer, P.H. and Li-Weber, M.
Oncotarget 7 (32): 51908-51921. 9 August 2016

Smac mimetic induces cell death in a large proportion of primary acute myeloid leukemia samples, which correlates with defined molecular markers.
Lueck, S.C. and Russ, A.C. and Botzenhardt, U. and Schlenk, R.F. and Zobel, K. and Deshayes, K. and Vucic, D. and Döhner, H. and Döhner, K. and Fulda, S. and Bullinger, L.
Oncotarget 7 (31): 49539-49551. 2 August 2016

Cross-validation of survival associated biomarkers in gastric cancer using transcriptomic data of 1,065 patients.
Szasz, A.M. and Lanczky, A. and Nagy, A. and Foerster, S. and Hark, K. and Green, J.E. and Boussioutas, A. and Busuttil, R. and Szabo, A. and Gyorffy, B.
Oncotarget 7 (31): 49322-49333. 2 August 2016

The activation of OR51E1 causes growth suppression of human prostate cancer cells.
Maßberg, D. and Jovancevic, N. and Offermann, A. and Simon, A. and Baniahmad, A. and Perner, S. and Pungsrinont, T. and Luko, K. and Philippou, S. and Ubrig, B. and Heiland, M. and Weber, L. and Altmüller, J. and Becker, C. and Gisselmann, G. and Gelis, L. and Hatt, H.
Oncotarget 7 (30): 48231-48249. 26 July 2016

The long non-coding RNA PARROT is an upstream regulator of c-Myc and affects proliferation and translation.
Vučićević, D. and Gehre, M. and Dhamija, S. and Friis-Hansen, L. and Meierhofer, D. and Sauer, S. and Ørom, U.A.
Oncotarget 7 (23): 33934-33947. 7 June 2016

A new role of the Rac-GAP β2-chimaerin in cell adhesion reveals opposite functions in breast cancer initiation and tumor progression.
Casado-Medrano, V. and Barrio-Real, L. and García-Rostán, G. and Baumann, M. and Rocks, O. and Caloca, M.J.
Oncotarget 7 (19): 28301-28319. 10 May 2016

KCNE2 and gastric cancer: bench to bedside.
Abbott, G.W. and Roepke, T.K.
Oncotarget 7 (14): 17286-17287. 5 April 2016

MicroRNA-34a promotes genomic instability by a broad suppression of genome maintenance mechanisms downstream of the oncogene KSHV-vGPCR.
Krause, C.J. and Popp, O. and Thirunarayanan, N. and Dittmar, G. and Lipp, M. and Mueller, G.
Oncotarget 7 (9): 10414-10432. 1 March 2016

Effects of RAF inhibitors on PI3K/AKT signalling depend on mutational status of the RAS/RAF signalling axis.
Fritsche-Guenther, R. and Witzel, F. and Kempa, S. and Brummer, T. and Sers, C. and Blüthgen, N.
Oncotarget 7 (7): 7960-7969. 20 January 2016

2015

Annexin A1 sustains tumor metabolism and cellular proliferation upon stable loss of HIF1A.
Rohwer, N. and Bindel, F. and Grimm, C. and Lin, S.J. and Wappler, J. and Klinger, B. and Blüthgen, N. and Du Bois, I. and Schmeck, B. and Lehrach, H. and de Graauw, M. and Goncalves, E. and Saez-Rodriguez, J. and Tan, P. and Grabsch, H.I. and Prigione, A. and Kempa, S. and Cramer, T.
Oncotarget 7 (6): 6693-6710. 29 December 2015

Loss of CX3CR1 increases accumulation of inflammatory monocytes and promotes gliomagenesis.
Feng, X. and Szulzewsky, F. and Yerevanian, A. and Chen, Z. and Heinzmann, D. and Rasmussen, R.D. and Alvarez-Garcia, V. and Kim, Y. and Wang, B. and Tamagno, I. and Zhou, H. and Li, X. and Kettenmann, H. and Ransohoff, R.M. and Hambardzumyan, D.
Oncotarget 6 (17): 15077-15094. 20 June 2015

Heregulin-HER3-HER2 signaling promotes matrix metalloproteinase-dependent blood-brain-barrier transendothelial migration of human breast cancer cell lines.
Momeny, M. and Saunus, J.M. and Marturana, F. and McCart Reed, A.E. and Black, D. and Sala, G. and Iacobelli, S. and Holland, J.D. and Yu, D. and Da Silva, L. and Simpson, P.T. and Khanna, K.K. and Chenevix-Trench, G. and Lakhani, S.R.
Oncotarget 6 (6): 3932-3946. 19 February 2015

2014

The BCL9-2 proto-oncogene governs estrogen receptor alpha expression in breast tumorigenesis.
Zatula, N. and Wiese, M. and Bunzendahl, J. and Birchmeier, W. and Perske, C. and Bleckmann, A. and Brembeck, F.H.
Oncotarget 5 (16): 6770-6787. 30 August 2014

RAGE mediates S100A4-induced cell motility via MAPK/ERK and hypoxia signaling and is a prognostic biomarker for human colorectal cancer metastasis.
Dahlmann, M. and Okhrimenko, A. and Marcinkowski, P. and Osterland, M. and Herrmann, P. and Smith, J. and Heizmann, C.W. and Schlag, P.M. and Stein, U.
Oncotarget 5 (10): 3220-3233. 30 May 2014

Loss of CADM1 expression is associated with poor prognosis and brain metastasis in breast cancer patients.
Wikman, H. and Westphal, L. and Schmid, F. and Pollari, S. and Kropidlowski, J. and Sielaff-Frimpong, B. and Glatzel, M. and Matschke, J. and Westphal, M. and Iljin, K. and Huhtala, H. and Terracciano, L. and Kallioniemi, A. and Sauter, G. and Mueller, V. and Witzel, I. and Lamszus, K. and Kemming, D. and Pantel, K.
Oncotarget 5 (10): 3076-3087. 30 May 2014

2013

BET bromodomain protein inhibition is a therapeutic option for medulloblastoma.
Henssen, A. and Thor, T. and Odersky, A. and Heukamp, L. and El-Hindy, N. and Beckers, A. and Speleman, F. and Althoff, K. and Schäfers, S. and Schramm, A. and Sure, U. and Fleischhack, G. and Eggert, A. and Schulte, J.H.
Oncotarget 4 (11): 2080-2095. November 2013

Adoptive T-cell therapy to treat liver cancer: Is the liver microenvironment key?
Willimsky, G. and Protzer, U. and Knolle, P. and Heikenwalder, M.
Oncotarget 4 (8): 1117-1118. August 2013

Cell death sensitization of leukemia cells by opioid receptor activation.
Friesen, C. and Roscher, M. and Hormann, I. and Fichtner, I. and Alt, A. and Hilger, R.A. and Debatin, K.M. and Miltner, E.
Oncotarget 4 (5): 677-690. 16 April 2013

2012

Burkitt lymphomagenesis linked to MYC plus PI3K in germinal center B cells.
Sander, S. and Rajewsky, K.
Oncotarget 3 (10): 1066-1067. 28 October 2012

Systemic shRNA mediated knock down of S100A4 in colorectal cancer xenografted mice reduces metastasis formation.
Dahlmann, M. and Sack, U. and Herrmann, P. and Lemm, M. and Fichtner, I. and Schlag, P.M. and Stein, U.
Oncotarget 3 (8): 783-797. 7 August 2012

2010

Interleukin-9 (IL-9) and NPM-ALK each generate mast cell hyperplasia as single 'hit' and cooperate in producing a mastocytosis-like disease in mice.
Merz, H. and Kaehler, C. and Hoefig, K.P. and Branke, B. and Uckert, W. and Nadrowitz, R. and Cerny-Reiterer, S. and Herrmann, H. and Feller, A.C. and Valent, P.
Oncotarget 1 (2): 104-119. 7 June 2010