Browse by Journal Title

2024

Structural insights into the activation mechanism of antimicrobial GBP1.
Weismehl, M., Chu, X., Kutsch, M., Lauterjung, P., Herrmann, C., Kudryashev, M. and Daumke, O.
EMBO Journal 43 (4): 615-636. 15 February 2024

2023

Adipocyte autophagy limits gut inflammation by controlling oxylipin and IL-10.
Richter, F.C., Friedrich, M., Kampschulte, N., Piletic, K., Alsaleh, G., Zummach, R., Hecker, J., Pohin, M., Ilott, N., Guschina, I., Wideman, S.K., Johnson, E., Borsa, M., Hahn, P., Morriseau, C., Hammock, B.D., Schipper, H.S., Edwards, C.M, Zechner, R., Siegmund, B., Weidinger, C., Schebb, N.H., Powrie, F. and Simon, A.K.
EMBO Journal 42 (6): e112202. 15 March 2023

2022

TSG101 associates with PARP1 and is essential for PARylation and DNA damage-induced NF-κB activation.
Tufan, A.B., Lazarow, K., Kolesnichenko, M., Sporbert, A., von Kries, J.P. and Scheidereit, C.
EMBO Journal 41 (21): e110372. 2 November 2022

The OTUD6B-LIN28B-MYC axis determines the proliferative state in multiple myeloma.
Paulmann, C., Spallek, R., Karpiuk, O., Heider, M., Schäffer, I., Zecha, J., Klaeger, S., Walzik, M., Öllinger, R., Engleitner, T., Wirth, M., Keller, U., Krönke, J., Rudelius, M., Kossatz, S., Rad, R., Kuster, B. and Bassermann, F.
EMBO Journal 41 (20): e110871. 17 October 2022

Gastric stem cells promote inflammation and gland remodeling in response to Helicobacter pylori via Rspo3-Lgr4 axis.
Wizenty, J., Müllerke, S., Kolesnichenko, M., Heuberger, J., Lin, M., Fischer, A.S., Mollenkopf, H.J., Berger, H., Tacke, F. and Sigal, M.
EMBO Journal 41 (13): e109996. 4 July 2022

Human UPF3A and UPF3B enable fault-tolerant activation of nonsense-mediated mRNA decay.
Wallmeroth, D., Lackmann, J.W., Kueckelmann, S., Altmüller, J., Dieterich, C., Boehm, V. and Gehring, N.H.
EMBO Journal 41 (10): e109191. 16 May 2022

The blood-brain barrier-a metabolic ecosystem.
Castro, M. and Potente, M.
EMBO Journal 41 (9): e111189. 2 May 2022

K27-linked ubiquitylation promotes p97 substrate processing and is essential for cell proliferation.
Shearer, R.F., Typas, D., Coscia, F., Schovsbo, S., Kruse, T., Mund, A. and Mailand, N.
EMBO Journal 41 (9): e110145. 2 May 2022

2021

Autophagy in major human diseases.
Klionsky, D.J., Petroni, G., Amaravadi, R.K., Baehrecke, E.H., Ballabio, A., Boya, P., Bravo-San Pedro, J.M., Cadwell, K., Cecconi, F., Choi, A.M.K., Choi, M.E., Chu, C.T., Codogno, P., Colombo, M.I., Cuervo, A.M., Deretic, V., Dikic, I., Elazar, Z., Eskelinen, E.L., Fimia, G.M., Gewirtz, D.A., Green, D.R., Hansen, M., Jäättelä, M., Johansen, T., Juhász, G., Karantza, V., Kraft, C., Kroemer, G., Ktistakis, N.T., Kumar, S., Lopez-Otin, C., Macleod, K.F., Madeo, F., Martinez, J., Meléndez, A., Mizushima, N., Münz, C., Penninger, J.M., Perera, R.M., Piacentini, M., Reggiori, F., Rubinsztein, D.C., Ryan, K.M., Sadoshima, J., Santambrogio, L., Scorrano, L., Simon, H.U., Simon, A.K., Simonsen, A., Stolz, A., Tavernarakis, N., Tooze, S.A., Yoshimori, T., Yuan, J., Yue, Z., Zhong, Q., Galluzzi, L. and Pietrocola, F.
EMBO Journal 40 (19): e108863. 1 October 2021

Transcriptional repression of NFKBIA triggers constitutive IKK- and proteasome-independent p65/RelA activation in senescence.
Kolesnichenko, M., Mikuda, N., Höpken, U.E., Kärgel, E., Uyar, B., Tufan, A.B., Milanovic, M., Sun, W., Krahn, I., Schleich, K., von Hoff, L., Hinz, M., Willenbrock, M., Jungmann, S., Akalin, A., Lee, S., Schmidt-Ullrich, R., Schmitt, C.A. and Scheidereit, C.
EMBO Journal 40 (6): e104296. 15 March 2021

The UBA domain of conjugating enzyme Ubc1/Ube2K facilitates assembly of K48/K63‐branched ubiquitin chains.
Pluska, L., Jarosch, E., Zauber, H., Kniss, A., Waltho, A., Bagola, K., von Delbrück, M., Löhr, F., Schulman, B.A., Selbach, M., Dötsch, V. and Sommer, T.
EMBO Journal 40 (6): e106094. 15 March 2021

Ythdf is a N6-methyladenosine reader that modulates Fmr1 target mRNA selection and restricts axonal growth in Drosophila.
Worpenberg, L., Paolantoni, C., Longhi, S., Mulorz, M.M., Lence, T., Wessels, H.H., Dassi, E., Aiello, G., Sutandy, F.X.R., Scheibe, M., Edupuganti, R.R., Busch, A., Möckel, M.M., Vermeulen, M., Butter, F., König, J., Notarangelo, M., Ohler, U., Dieterich, C., Quattrone, A., Soldano, A. and Roignant, J.Y.
EMBO Journal 40 (4): e104975. 15 February 2021

2020

Who with whom: functional coordination of E2 enzymes by RING E3 ligases during poly-ubiquitylation.
Lips, C., Ritterhoff, T., Weber, A., Janowska, M.K., Mustroph, M., Sommer, T. and Klevit, R.E.
EMBO Journal 39 (22): e104863. 16 November 2020

Uncoupling endosomal CLC chloride/proton exchange causes severe neurodegeneration.
Weinert, S., Gimber, N., Deuschel, D., Stuhlmann, T., Puchkov, D., Farsi, Z., Ludwig, C.F., Novarino, G., López-Cayuqueo, K.I., Planells-Cases, R. and Jentsch, T.J.
EMBO Journal 39 (9): e103358. 4 May 2020

2019

Nomenclature for cellular plasticity: are the terms as plastic as the cells themselves?
Mills, J.C., Stanger, B.Z. and Sander, M.
EMBO Journal 38 (19): e103148. 1 October 2019

Bhlhe40 and Bhlhe41 transcription factors regulate alveolar macrophage self-renewal and identity.
Rauschmeier, R., Gustafsson, C., Reinhardt, A., A-Gonzalez, N., Tortola, L., Cansever, D., Subramanian, S., Taneja, R., Rossner, M.J., Sieweke, M.H., Greter, M., Månsson, R., Busslinger, M. and Kreslavsky, T.
EMBO Journal 38 (19): e101233. 1 October 2019

Efficient mitotic checkpoint signaling depends on integrated activities of Bub1 and the RZZ complex.
Zhang, G., Kruse, T., Guasch Boldú, C., Garvanska, D.H., Coscia, F., Mann, M., Barisic, M. and Nilsson, J.
EMBO Journal 38 (7): e100977. 1 April 2019

2018

The IκB kinase complex is a regulator of mRNA stability.
Mikuda, N., Kolesnichenko, M., Beaudette, P., Popp, O., Uyar, B., Sun, W., Tufan, A.B., Perder, B., Akalin, A., Chen, W., Mertins, P., Dittmar, G., Hinz, M. and Scheidereit, C.
EMBO Journal 37 (24): e98658. 14 December 2018

Neuregulin 3 promotes excitatory synapse formation on hippocampal interneurons.
Müller, T., Braud, S., Jüttner, R., Voigt, B.C., Paulick, K., Sheean, M.E., Klisch, C., Gueneykaya, D., Rathjen, F.G., Geiger, J.R.P., Poulet, J.F.A. and Birchmeier, C.
EMBO Journal 37 (17): e98858. 3 September 2018

Reorganization of inter-chromosomal interactions in the 2q37-deletion syndrome.
Maass, P.G., Weise, A., Rittscher, K., Lichtenwald, J., Barutcu, A.R., Liehr, T., Aydin, A., Wefeld-Neuenfeld, Y., Pölsler, L., Tinschert, S., Rinn, J.L., Luft, F.C. and Bähring, S.
EMBO Journal 37 (15): e96257. 1 August 2018

High-throughput identification of RNA nuclear enrichment sequences.
Shukla, C.J., McCorkindale, A.L., Gerhardinger, C., Korthauer, K.D., Cabili, M.N., Shechner, D.M., Irizarry, R.A., Maass, P. and Rinn, J.L.
EMBO Journal 37 (6): e98452. 15 March 2018

Complete suppression of Htt fibrilization and disaggregation of Htt fibrils by a trimeric chaperone complex.
Scior, A., Buntru, A., Arnsburg, K., Ast, A., Iburg, M., Juenemann, K., Pigazzini, M.L., Mlody, B., Puchkov, D., Priller, J., Wanker, E.E., Prigione, A. and Kirstein, J.
EMBO Journal 37 (2): 282-299. 17 January 2018

2017

Casein kinase 1-epsilon or 1-delta required for Wnt-mediated intestinal stem cell maintenance.
Morgenstern, Y., Das Adhikari, U., Ayyash, M., Elyada, E., Tóth, B., Moor, A., Itzkovitz, S. and Ben-Neriah, Y.
EMBO Journal 36 (20): 3046-3061. 16 October 2017

New Q(ues) to keep blood vessels growing.
Andrade, J. and Potente, M.
EMBO Journal 36 (16): 2315-2317. 15 August 2017

SIRT1 regulates macrophage self-renewal.
Imperatore, F., Maurizio, J., Vargas Aguilar, S., Busch, C.J., Favret, J., Kowenz-Leutz, E., Cathou, W., Gentek, R., Perrin, P., Leutz, A., Berruyer, C. and Sieweke, M.H.
EMBO Journal 36 (16): 2353-2372. 15 August 2017

The MYCmRNA3'-UTR couples RNA polymerase II function to glutamine and ribonucleotide levels.
Dejure, F.R., Royla, N., Herold, S., Kalb, J., Walz, S., Ade, C.P., Mastrobuoni, G., Vanselow, J.T., Schlosser, A., Wolf, E., Kempa, S. and Eilers, M.
EMBO Journal 36 (13): 1854-1868. 3 July 2017

Molecular definitions of autophagy and related processes.
Galluzzi, L., Baehrecke, E.H., Ballabio, A., Boya, P., Bravo-San Pedro, J.M., Cecconi, F., Choi, A.M., Chu, C.T., Codogno, P., Colombo, M.I., Cuervo, A.M., Debnath, J., Deretic, V., Dikic, I., Eskelinen, E.L., Fimia, G.M., Fulda, S., Gewirtz, D.A., Green, D.R., Hansen, M., Harper, J.W., Jäättelä, M., Johansen, T., Juhasz, G., Kimmelman, A.C., Kraft, C., Ktistakis, N.T., Kumar, S., Levine, B., Lopez-Otin, C., Madeo, F., Martens, S., Martinez, J., Melendez, A., Mizushima, N., Münz, C., Murphy, L.O., Penninger, J.M., Piacentini, M., Reggiori, F., Rubinsztein, D.C., Ryan, K.M., Santambrogio, L., Scorrano, L., Simon, A.K., Simon, H.U., Simonsen, A., Tavernarakis, N., Tooze, S.A., Yoshimori, T., Yuan, J., Yue, Z., Zhong, Q. and Kroemer, G.
EMBO Journal 36 (13): 1811-1836. 3 July 2017

2016

Myeloid leukemia with transdifferentiation plasticity developing from T-cell progenitors.
Riemke, P., Czeh, M., Fischer, J., Walter, C., Ghani, S., Zepper, M., Agelopoulos, K., Lettermann, S., Gebhardt, M.L., Mah, N., Weilemann, A., Grau, M., Groening, V., Haferlach, T., Lenze, D., Delwel, R., Prinz, M., Andrade-Navarro, M.A., Lenz, G., Dugas, M., Mueller-Tidow, C. and Rosenbauer, F.
EMBO Journal 35 (22): 2399-2416. 15 November 2016

Membrane fission by dynamin: what we know and what we need to know.
Antonny, B., Burd, C., De Camilli, P., Chen, E., Daumke, O., Faelber, K., Ford, M., Frolov, V.A., Frost, A., Hinshaw, J.E., Kirchhausen, T., Kozlov, M.M., Lenz, M., Low, H.H., McMahon, H., Merrifield, C., Pollard, T.D., Robinson, P.J., Roux, A. and Schmid, S.
EMBO Journal 35 (21): 2270-2284. 2 November 2016

Relief of hypoxia by angiogenesis promotes neural stem cell differentiation by targeting glycolysis.
Lange, C., Turrero Garcia, M., Decimo, I., Bifari, F., Eelen, G., Quaegebeur, A., Boon, R., Zhao, H., Boeckx, B., Chang, J., Wu, C., le Noble, F., Lambrechts, D., Dewerchin, M., Kuo, C.J., Huttner, W.B. and Carmeliet, P.
EMBO Journal 35 (9): 924-941. 2 May 2016

The transcriptional coactivator Bob1 promotes the development of follicular T helper cells via Bcl6.
Stauss, D., Brunner, C., Berberich-Siebelt, F., Höpken, U.E., Lipp, M. and Müller, G.
EMBO Journal 35 (8): 881-898. 15 April 2016

Putting chromatin in its place: the pioneer factor NeuroD1 modulates chromatin state to drive cell fate decisions.
Glahs, A. and Zinzen, R.P.
EMBO Journal 35 (1): 1-3. 4 January 2016

Gatekeeper role of brain antigen-presenting CD11c(+) cells in neuroinflammation.
Paterka, M., Siffrin, V., Voss, J.O., Werr, J., Hoppmann, N., Gollan, R., Belikan, P., Bruttger, J., Birkenstock, J., Jung, S., Esplugues, E., Yogev, N., Flavell, R.A., Bopp, T. and Zipp, F.
EMBO Journal 35 (1): 89-101. 4 January 2016

2015

Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt-based anti-cancer drugs.
Planells-Cases, R., Lutter, D., Guyader, C., Gerhards, N.M., Ullrich, F., Elger, D.A., Kucukosmanoglu, A., Xu, G., Voss, F.K., Reincke, S.M., Stauber, T., Blomen, V.A., Vis, D.J., Wessels, L.F., Brummelkamp, T.R., Borst, P., Rottenberg, S. and Jentsch, T.J.
EMBO Journal 34 (24): 2993-3008. December 2015

The tRNA methyltransferase Dnmt2 is required for accurate polypeptide synthesis during haematopoiesis.
Tuorto, F., Herbst, F., Alerasool, N., Bender, S., Popp, O., Federico, G., Reitter, S., Liebers, R., Stoecklin, G., Groene, H.J., Dittmar, G., Glimm, H. and Lyko, F.
EMBO Journal 34 (18): 2350-2362. 14 September 2015

Molecular profiling of CD8 T cells in autochthonous melanoma identifies Maf as driver of exhaustion.
Giordano, M., Henin, C., Maurizio, J., Imbratta, C., Bourdely, P., Buferne, M., Baitsch, L., Vanhille, L., Sieweke, M.H., Speiser, D.E., Auphan-Anezin, N., Schmitt-Verhulst, A.M. and Verdeil, G.
EMBO Journal 34 (15): 2042-2058. 4 August 2015

Departure gate of acidic Ca(2+) confirmed.
Jentsch, T.J., Hoegg-Beiler, M.B. and Vogt, J.
EMBO Journal 34 (13): 1737-1739. 2 July 2015

Simply the right time to turn on insulin.
Spagnoli, F.M.
EMBO Journal 34 (13): 1740-1742. 2 July 2015

Shp2 signaling suppresses senescence in PyMT-induced mammary gland cancer in mice.
Lan, L., Holland, J.D., Qi, J., Grosskopf, S., Rademann, J., Vogel, R., Gyoerffy, B., Wulf-Goldenberg, A. and Birchmeier, W.
EMBO Journal 34 (11): 1493-1508. 3 June 2015

Insm1 cooperates with Neurod1 and Foxa2 to maintain mature pancreatic β-cell function.
Jia, S., Ivanov, A., Blasevic, D., Müller, T., Purfürst, B., Sun, W., Chen, W., Poy, M.N., Rajewsky, N. and Birchmeier, C.
EMBO Journal 34 (10): 1417-1433. 12 May 2015

2014

Discrete Notch signaling requirements in the specification of hematopoietic stem cells.
Kim, A.D., Melick, C.H., Clements, W.K., Stachura, D.L., Distel, M., Panáková, D., MacRae, C., Mork, L.A., Crump, J.G. and Traver, D.
EMBO Journal 33 (20): 2363-2373. 16 October 2014

Global characterization of the oocyte-to-embryo transition in Caenorhabditis elegans uncovers a novel mRNA clearance mechanism.
Stoeckius, M., Grün, D., Kirchner, M., Ayoub, S., Torti, F., Piano, F., Herzog, M., Selbach, M. and Rajewsky, N.
EMBO Journal 33 (16): 1751-1766. 18 August 2014

Paternal RNA contributions in the Caenorhabditis elegans zygote.
Stoeckius, M., Grün, D. and Rajewsky, N.
EMBO Journal 33 (16): 1740-1750. 18 August 2014

Identification of small ORFs in vertebrates using ribosome footprinting and evolutionary conservation.
Bazzini, A.A., Johnstone, T.G., Christiano, R., Mackowiak, S.D., Obermayer, B., Fleming, E.S., Vejnar, C.E., Lee, M.T., Rajewsky, N., Walther, T.C. and Giraldez, A.J.
EMBO Journal 33 (9): 981-993. 2 May 2014

Gene expression: degrade to derepress.
McShane, E. and Selbach, M.
EMBO Journal 33 (5): 407-408. 3 March 2014

2013

PP2A regulatory subunit Bα controls endothelial contractility and vessel lumen integrity via regulation of HDAC7.
Martin, M., Geudens, I., Bruyr, J., Potente, M., Bleuart, A., Lebrun, M., Simonis, N., Deroanne, C., Twizere, J.C., Soubeyran, P., Peixoto, P., Mottet, D., Janssens, V., Hofmann, W.K., Claes, F., Carmeliet, P., Kettmann, R., Gerhardt, H. and Dequiedt, F.
EMBO Journal 32 (18): 2491-2503. 11 September 2013

MicroRNA-17~92 plays a causative role in lymphomagenesis by coordinating multiple oncogenic pathways.
Jin, H.Y., Oda, H., Lai, M., Skalsky, R.L., Bethel, K., Shepherd, J., Kang, S.G., Liu, W.H., Sabouri-Ghomi, M., Cullen, B.R., Rajewsky, K. and Xiao, C.
EMBO Journal 32 (17): 2377-2391. 28 August 2013

Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles.
Cheret, C., Willem, M., Fricker, F.R., Wende, H., Wulf-Goldenberg, A., Tahirovic, S., Nave, K.A., Saftig, P., Haass, C., Garratt, A.N., Bennett, D.L. and Birchmeier, C.
EMBO Journal 32 (14): 2015-2028. 17 July 2013

Ultra-deep profiling of alternatively spliced Drosophila Dscam isoforms by circularization-assisted multi-segment sequencing.
Sun, W., You, X., Gogol-Doering, A., He, H., Kise, Y., Sohn, M., Chen, T., Klebes, A., Schmucker, D. and Chen, W.
EMBO Journal 32 (14): 2029-2038. 17 July 2013

Wnt/β-catenin signalling induces MLL to create epigenetic changes in salivary gland tumours.
Wend, P., Fang, L., Zhu, Q., Schipper, J.H., Loddenkemper, C., Kosel, F., Brinkmann, V., Eckert, K., Hindersin, S., Holland, J.D., Lehr, S., Kahn, M., Ziebold, U. and Birchmeier, W.
EMBO Journal 32 (14): 1977-1989. 17 July 2013

The chromodomain helicase Chd4 is required for Polycomb-mediated inhibition of astroglial differentiation.
Sparmann, A., Xie, Y., Verhoeven, E., Vermeulen, M., Lancini, C., Gargiulo, G., Hulsman, D., Mann, M., Knoblich, J.A. and van Lohuizen, M.
EMBO Journal 32 (11): 1598-1612. 29 May 2013

Structural insights into oligomerization and mitochondrial remodelling of dynamin 1-like protein.
Fröhlich, C., Grabiger, S., Schwefel, D., Faelber, K., Rosenbaum, E., Mears, J., Rocks, O. and Daumke, O.
EMBO Journal 32 (9): 1280-1292. 2 May 2013

2012

A stomatin dimer modulates the activity of acid-sensing ion channels.
Brand, J., Smith, E.S.J., Schwefel, D., Lapatsina, L., Poole, K., Omerbasic, D., Kozlenkov, A., Behlke, J., Lewin, G.R. and Daumke, O.
EMBO Journal 31 (17): 3635-3646. 29 August 2012

A dual function of Bcl11b/Ctip2 in hippocampal neurogenesis.
Simon, R., Brylka, H., Schwegler, H., Venkataramanappa, S., Andratschke, J., Wiegreffe, C., Liu, P., Fuchs, E., Jenkins, N.A., Copeland, N.G., Birchmeier, C. and Britsch, S.
EMBO Journal 31 (13): 2922-2936. 15 May 2012

Gene expression of pluripotency determinants is conserved between mammalian and planarian stem cells.
Onal, P., Gruen, D., Adamidi, C., Rybak, A., Solana, J., Mastrobuoni, G., Wang, Y., Rahn, H.P., Chen, W., Kempa, S., Ziebold, U. and Rajewsky, N.
EMBO Journal 31 (12): 2755-2769. 27 April 2012

The SNF2-like helicase HELLS mediates E2F3-dependent transcription and cellular transformation.
von Eyss, B., Maaskola, J., Memczak, S., Möllmann, K., Schuetz, A., Loddenkemper, C., Tanh, M.D., Otto, A., Muegge, K., Heinemann, U., Rajewsky, N. and Ziebold, U.
EMBO Journal 31 (4): 972-985. 15 February 2012

Raising cytosolic Cl(-) in cerebellar granule cells affects their excitability and vestibulo-ocular learning.
Seja, P., Schonewille, M., Spitzmaul, G., Badura, A., Klein, I., Rudhard, Y., Wisden, W., Huebner, C.A., De Zeeuw, C.I. and Jentsch, T.J.
EMBO Journal 31 (5): 1217-1230. 17 January 2012

Axonal transcription factors signal retrogradely in lesioned peripheral nerve.
Ben-Yaakov, K., Dagan, S.Y., Segal-Ruder, Y., Shalem, O., Vuppalanchi, D., Willis, D.E., Yudin, D., Rishal, I., Rother, F., Bader, M., Blesch, A., Pilpel, Y., Twiss, J.L. and Fainzilber, M.
EMBO Journal 31 (6): 1350-1363. 13 January 2012

Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease.
Schmidt, V., Baum, K., Lao, A., Rateitschak, K., Schmitz, Y., Teichmann, A., Wiesner, B., Petersen, C.M., Nykjaer, A., Wolf, J., Wolkenhauer, O. and Willnow, T.E.
EMBO Journal 31 (1): 187-200. 4 January 2012

2011

ClC-7 is a slowly voltage-gated 2Cl(-)/1H(+)-exchanger and requires Ostm1 for transport activity.
Leisle, L., Ludwig, C.F., Wagner, F.A., Jentsch, T.J. and Stauber, T.
EMBO Journal 30 (11): 2140-2152. 1 June 2011

Re-dicing the pancreatic beta-cell: do microRNAs define cellular identity?
Tattikota, S.G. and Poy, M.N.
EMBO Journal 30 (5): 797-799. 2 March 2011

CSN complex controls the stability of selected synaptic proteins via a torsinA-dependent process.
Granata, A., Koo, S.J., Haucke, V., Schiavo, G. and Warner, T.T.
EMBO Journal 30 (1): 181-193. 5 January 2011

2010

Heat shock factor 1 ameliorates proteotoxicity in cooperation with the transcription factor NFAT.
Hayashida, N., Fujimoto, M., Tan, K., Prakasam, R., Shinkawa, T., Li, L., Ichikawa, H., Takii, R. and Nakai, A.
EMBO Journal 29 (20): 3459-3469. 20 October 2010

Focus on the spatial organization of signalling.
Schwarz-Romond, T. and Gorski, S.A.
EMBO Journal 29 (16): 2675-2676. 18 August 2010

Crosstalk between C/EBPbeta phosphorylation, arginine methylation, and SWI/SNF/Mediator implies an indexing transcription factor code.
Kowenz-Leutz, E., Pless, O., Dittmar, G., Knoblich, M. and Leutz, A.
EMBO Journal 29 (6): 1105-1115. 17 March 2010

Evidence for a protein tether involved in somatic touch.
Hu, J., Chiang, L.Y., Koch, M. and Lewin, G.R.
EMBO Journal 29 (4): 855-867. 17 February 2010

2009

Transcription factor C/EBPbeta isoform ratio regulates osteoclastogenesis through MafB.
Smink, J.J., Bégay, V., Schoenmaker, T., Sterneck, E., de Vries, T.J. and Leutz, A.
EMBO Journal 28 (12): 1769-1781. 17 June 2009

SLP-2 is required for stress-induced mitochondrial hyperfusion.
Tondera, D., Grandemange, S., Jourdain, A., Karbowski, M., Mattenberger, Y., Herzig, S., Da Cruz, S., Clerc, P., Raschke, I., Merkwirth, C., Ehses, S., Krause, F., Chan, D.C., Alexander, C., Bauer, C., Youle, R., Langer, T. and Martinou, J.C.
EMBO Journal 28 (11): 1589-1600. 3 June 2009

Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development.
Lechner, S.G., Frenzel, H., Wang, R. and Lewin, G.R.
EMBO Journal 28 (10): 1479-1491. 20 May 2009

Active promoters and insulators are marked by the centrosomal protein 190.
Bartkuhn, M., Straub, T., Herold, M., Herrmann, M., Rathke, C., Saumweber, H., Gilfillan, G.D., Becker, P.B. and Renkawitz, R.
EMBO Journal 28 (7): 877-888. 8 April 2009

2008

Gq-coupled receptors as mechanosensors mediating myogenic vasoconstriction.
Mederos y Schnitzler, M., Storch, U., Meibers, S., Nurwakagari, P., Breit, A., Essin, K., Gollasch, M. and Gudermann, T.
EMBO Journal 27 (23): 3092-3103. 3 December 2008

Endocochlear potential depends on Cl(-) channels: mechanism underlying deafness in Bartter syndrome IV.
Rickheit, G., Maier, H., Strenzke, N., Andreescu, C.E., De Zeeuw, C.I., Muenscher, A., Zdebik, A.A. and Jentsch, T.J.
EMBO Journal 27 (21): 2907-2917. 5 November 2008

2007

Malt1 ubiquitination triggers NF-kappaB signaling upon T-cell activation.
Oeckinghaus, A., Wegener, E., Welteke, V., Ferch, U., Coel Arslan, S., Ruland, J., Scheidereit, C. and Krappmann, D.
EMBO Journal 26 (22): 4634-4645. 14 November 2007

The Drosophila insulator proteins CTCF and CP190 link enhancer blocking to body patterning.
Mohan, M., Bartkuhn, M., Herold, M., Philippen, A., Heinl, N., Bardenhagen, I., Leers, J., White, R.A.H., Renkawitz-Pohl, R., Saumweber, H. and Renkawitz, R.
EMBO Journal 26 (19): 4203-4214. 3 October 2007

The Kruppel-like factor KLF4 is a critical regulator of monocyte differentiation.
Feinberg, M.W., Wara, A.K., Cao, Z., Lebedeva, M.A., Rosenbauer, F., Iwasaki, H., Hirai, H., Katz, J.P., Haspel, R., Gray, S., Akashi, K., Segre, J., Kaestner, K.H., Tenen, D.G. and Jain, M.K.
EMBO Journal 26 (18): 4138-4148. 19 September 2007

Splicing factors stimulate polyadenylation via USEs at non-canonical 3' end formation signals.
Danckwardt, S., Kaufmann, I., Gentzel, M., Foerstner, K.U., Gantzert, A.S., Gehring, N.H., Neu-Yilik, G., Bork, P., Keller, W., Wilm, M., Hentze, M.W. and Kulozik, A.E.
EMBO Journal 26 (11): 2658-2669. 6 June 2007

2006

The Hrd1p ligase complex forms a linchpin between ER-lumenal substrate selection and Cdc48p recruitment.
Gauss, R., Sommer, T. and Jarosch, E.
EMBO Journal 25 (9): 1827-1835. 3 May 2006

An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis.
Boeddrich, A., Gaumer, S., Haacke, A., Tzvetkov, N., Albrecht, M., Evert, B.O., Mueller, E.C., Lurz, R., Breuer, P., Schugardt, N., Plassmann, S., Xu, K., Warrick, J.M., Suopanki, J., Wuellner, U., Frank, R., Hartl, U.F., Bonini, N.M. and Wanker, E.E.
EMBO Journal 25 (7): 1547-1558. 5 April 2006

Mice with altered KCNQ4 K+ channels implicate sensory outer hair cells in human progressive deafness.
Kharkovets, T., Dedek, K., Maier, H., Schweizer, M., Khimich, D., Nouvian, R., Vardanyan, V., Leuwer, R., Moser, T. and Jentsch, T.J.
EMBO Journal 25 (3): 642-652. 8 February 2006

2005

Homo- and heterodimerization of APP family members promotes intercellular adhesion.
Soba, P., Eggert, S., Wagner, K., Zentgraf, H., Siehl, K., Kreger, S., Loewer, A., Langer, A., Merdes, G., Paro, R., Masters, C.L., Mueller, U., Kins, S. and Beyreuther, K.
EMBO Journal 24 (20): 3624-3634. 19 October 2005

Urokinase-induced signaling in human vascular smooth muscle cells is mediated by PDGFR-beta.
Kiyan, J., Kiyan, R., Haller, H. and Dumler, I.
EMBO Journal 24 (10): 1787-1797. 18 May 2005

Loss of the chloride channel ClC-7 leads to lysosomal storage disease and neurodegeneration.
Kasper, D., Planells-Cases, R., Fuhrmann, J.C., Scheel, O., Zeitz, O., Ruether, K., Schmitt, A., Poet, M., Steinfeld, R., Schweizer, M., Kornak, U. and Jentsch, T.J.
EMBO Journal 24 (5): 1079-1091. 9 March 2005

Structure of palmitoylated BET3: insights into TRAPP complex assembly and membrane localization.
Turnbull, A.P., Kuemmel, D., Prinz, B., Holz, C., Schultchen, J., Lang, C., Niesen, F.H., Hofmann, K.P., Delbrueck, H., Behlke, J., Mueller, E.C., Jarosch, E., Sommer, T. and Heinemann, U.
EMBO Journal 24 (5): 875-884. 1 January 2005

2004

Interference of human and Drosophila APP and APP-like proteins with PNS development in Drosophila.
Merdes, G., Soba, P., Loewer, A., Bilic, M.V., Beyreuther, K. and Paro, R.
EMBO Journal 23 (20): 4082-4095. 13 October 2004

Biochemical analysis of TREX complex recruitment to intronless and intron-containing yeast genes.
Abruzzi, K.C., Lacadie, S. and Rosbash, M.
EMBO Journal 23 (13): 2620-2631. 7 July 2004

2003

Loss of K-Cl co-transporter KCC3 causes deafness, neurodegeneration and reduced seizure threshold.
Boettger, T., Rust, M.B., Maier, H., Seidenbecher, T., Schweizer, M., Keating, D.J., Faulhaber, J., Ehmke, H., Pfeffer, C., Scheel, O., Lemcke, B., Horst, J., Leuwer, R., Pape, H.C., Voelkl, H., Huebner, C.A. and Jentsch, T.J.
EMBO Journal 22 (20): 5422-5434. 15 October 2003

Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway.
Gillissen, B., Essmann, F., Graupner, V., Staerck, L., Radetzki, S., Doerken, B., Schulze-Osthoff, K. and Daniel, P.T.
EMBO Journal 22 (14): 3580-3590. 15 July 2003

The Helicobacter pylori CagA protein induces cortactin dephosphorylation and actin rearrangement by c-Src inactivation.
Selbach, M., Moese, S., Hurwitz, R., Hauck, C.R., Meyer, T.F. and Backert, S.
EMBO Journal 22 (3): 515-528. 3 February 2003

Nonsense-mediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathways.
Gatfield, D., Unterholzner, L., Ciccarelli, F.D., Bork, P. and Izaurralde, E.
EMBO Journal 22 : 3960-3970. 1 January 2003

2002

Exportin-5-mediated nuclear export of eukaryotic elongation factor 1A and tRNA.
Calado, A., Treichel, N., Mueller, E.C., Otto, A. and Kutay, U.
EMBO Journal 21 (22): 6216-6224. 15 November 2002

EcoRII: a restriction enzyme evolving recombination functions.
Muecke, M., Grelle, G., Behlke, J., Kraft, R., Krueger, D.H. and Reuter, M.
EMBO Journal 21 (19): 5262-5268. 1 October 2002

Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy.
Enge, M., Bjarnegård, M., Gerhardt, H., Gustafsson, E., Kalén, M., Asker, N., Hammes, H.-P., Shani, M., Fässler, R. and Betsholtz, C.
EMBO Journal 21 (16): 4307-4316. 15 August 2002

Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B.
Mathas, S., Hinz, M., Anagnostopoulos, L., Krappmann, D., Lietz, A., Jundt, F., Bommert, K., Mechta-Grigoriou, F., Stein, H., Dörken, B. and Scheidereit, C.
EMBO Journal 21 (15): 4104-4113. 1 August 2002

VDAC and the bacterial porin PorB of Neisseria gonorrhoeae share mitochondrial import pathways.
Mueller, A., Rassow, J., Grimm, J., Machuy, N., Meyer, T.F. and Rudel, T.
EMBO Journal 21 (8): 1916-1929. 15 April 2002

The Wilms' tumor gene Wt1 is required for normal development of the retina.
Wagner, K.D., Wagner, N., Vidal, V.P.I., Schley, G., Wilhelm, D., Schedl, A., Englert, C. and Scholz, H.
EMBO Journal 21 : 1398-1405. 1 January 2002

2001

Signal peptide cleavage of a type I membrane protein, HCMV US11, is dependent on its membrane anchor.
Rehm, A., Stern, P., Ploegh, H.L. and Tortorella, D.
EMBO Journal 20 (7): 1573-1582. 2 April 2001

Male germ cells and photoreceptors, both dependent on close cell-cell interactions, degenerate upon ClC-2 Cl(-) channel disruption.
Boesl, M.R., Stein, V., Huebner, C.A., Zdebik, A.A., Jordt, S.E., Mukhopadhyay, A.K., Davidoff, M.S., Holstein, A.F. and Jentsch, T.J.
EMBO Journal 20 (6): 1289-1299. 15 March 2001

COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system.
Bech-Otschir, D., Kraft, R., Huang, X.H., Henklein, P., Kapelari, B., Pollmann, C. and Dubiel, W.
EMBO Journal 20 (7): 1630-1639. 1 January 2001

Importin 13: a novel mediator of nuclear import and export.
Mingot, J.M., Kostka, S., Kraft, R., Hartmann, E. and Goerlich, D.
EMBO Journal 20 : 3685-3694. 1 January 2001

Sm protein-Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure.
Urlaub, H., Raker, V.A., Kostka, S. and Luehrmann, R.
EMBO Journal 20 (1-2): 187-196. 1 January 2001

Sec61p-independent degradation of the tail-anchored ER membrane protein Ubc6p.
Walter, J., Urban, J., Volkwein, C. and Sommer, T.
EMBO Journal 20 (12): 3124-3131. 1 January 2001

2000

Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes.
Lipowsky, G., Bischoff, F.R., Schwarzmaier, P., Kraft, R., Kostka, S., Hartmann, E., Kutay, U. and Goerlich, D.
EMBO Journal 19 : 4362-4371. 15 August 2000

Crystal structure of human sex hormone-binding globulin: steroid transport by a laminin G-like domain.
Grishkovskaya, I., Avvakumov, G.V., Sklenar, G., Dales, D., Hammond, G.L. and Muller, Y.A.
EMBO Journal 19 (4): 504-512. 15 February 2000

NKX2.3 is required for MAdCAM-1 expression and homing of lymphocytes in spleen and mucosa-associated lymphoid tissue.
Pabst, O., Foerster, R., Lipp, M., Engel, H. and Arnold, H.H.
EMBO Journal 19 (9): 2015-2023. 1 January 2000

1999

p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c-independent apoptosis blocked by Bcl-2.
Li, P.F., Dietz, R. and von Harsdorf, R.
EMBO Journal 18 (21): 6027-6036. 1 November 1999

Pathological missense mutations of neural cell adhesion molecule L1 affect hemophilic and heterophilic binding activities.
De Angelis, E., MacFarlane, J., Du, J.S., Yeo, G., Hicks, R., Rathjen, F.G., Kenwrick, S. and Bruemmendorf, T.
EMBO Journal 18 : 4744-4753. 1 September 1999

NF-kappaB p105 is a target of I kappaB kinases and controls signal induction of Bcl-3-p50 complexes.
Heissmeyer, V., Krappmann, D., Wulczyn, F.G. and Scheidereit, C.
EMBO Journal 18 : 4766-4778. 1 September 1999

1998

CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation.
Hacker, H., Mischak, H., Miethke, T., Liptay, S., Schmid, R., Sparwasser, T., Heeg, K., Lipford, G.B. and Wagner, H.
EMBO Journal 17 (21): 6230-6240. 2 November 1998

Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation.
Engel, K., Kotlyarov, A. and Gaestel, M.
EMBO Journal 17 : 3363-3371. 1 January 1998

1997

Molecular dissection of gating in the ClC-2 chloride channel.
Jordt, S.E. and Jentsch, T.J.
EMBO Journal 16 (7): 1582-1592. 1 April 1997

Transgenic expression in the liver of truncated Met blocks apoptosis and permits immortalization of hepatocytes.
Amicone, L., Spagnoli, F.M., Spaeth, G., Giordano, S., Tommasini, C., Bernardini, S., De Luca, V., Della Rocca, C., Weiss, M.C., Comoglio, P.M. and Tripodi, M.
EMBO Journal 16 (3): 495-503. 3 February 1997

Binding of non native-protein to Hsp25 during heat shock creates a reservoir of folding intermediates for reactivation.
Ehrnsperger, M., Graeber, S., Gaestel, M. and Buchner, J.
EMBO Journal 16 : 221-229. 1 January 1997

CREB is activated by UVC through a p38/HOG-1- dependent protein kinase.
Iordanov, M., Bender, K., Ade, T., Schmid, W., Sachsenmaier, C., Engel, K., Gaestel, M., Rahmsdorf, H.J. and Herrlich, P.
EMBO Journal 16 : 1009-1022. 1 January 1997

1996

Analysis of mammalian 20S proteasome biogenesis: the maturation of beta-subunits is an ordered two-step mechanism involving autocatalysis.
Schmidtke, G., Kraft, R., Kostka, S., Henklein, P., Froemmel, C., Loewe, J., Huber, R., Kloetzel, P.M. and Schmidt, M.
EMBO Journal 15 (24): 6887-6898. 16 December 1996

Different mechanisms control signal-induced degradation and basal turnover of the NF-kappab inhibitor ikappabalpha in vivo.
Krappmann, D., Wulczyn, F.G. and Scheidereit, C.
EMBO Journal 15 (23): 6716-6726. 2 December 1996

The HeLa 200 kDa U5 snRNP-specific protein and its homologue in Saccharomyces cerevisiae are members of the DEXH-box protein family of putative RNA helicaces.
Lauber, J., Fabrizio, P., Teigelkamp, S., Lane, W.S., Hartmann, E. and Luehrmann, R.
EMBO Journal 15 (15): 4001-4015. 1 August 1996

A 41 amino acid motif in importin-alpha confers binding to importin-beta and hence transit into the nucleus.
Goerlich, D., Henklein, P., Laskey, R.A. and Hartmann, E.
EMBO Journal 15 (8): 1810-1817. 15 April 1996

Degradation of subunits of the Sec61p complex, an integral component of the ER membrane, by the ubiquitin-proteasome pathway.
Biederer, T., Volkwein, C. and Sommer, T.
EMBO Journal 15 : 2069-2076. 1 January 1996

A second trimeric complex containing homologs of the Sec61p complex functions in protein transport across the ER membrane of S.cerevisiae.
Finke, K., Plath, K., Panzner, S., Prehn, S., Rapoport, T.A., Hartmann, E. and Sommer, T.
EMBO Journal 15 (7): 1482-1494. 1 January 1996

RAP, a specialized chaperone, prevents ligand-induced er retention and degradation of LDL receptor-related endocytic receptors.
Willnow, T.E., Rohlmann, A., Horton, J., Otani, H., Braun, J.R., Hammer, R.E. and Herz, J.
EMBO Journal 15 (11): 2632-2639. 1 January 1996

1995

Transport route for synaptobrevin via a novel pathway of insertion into the endoplasmatic reticulum membrane.
Kutay, U., Ahnert-Hilger, G., Hartmann, E., Wiedenmann, B. and Rapoport, T.A.
EMBO Journal 14 : 217-223. 1 January 1995

NF-M (chicken C/EBP beta) induces eosinophilic differentiation and apoptosis in a hematopoietic progenitor cell line.
Mueller, C., Kowenz-Leutz, E., Grieser-Ade, S., Graf, T. and Leutz, A.
EMBO Journal 14 (24): 6127-6135. 1 January 1995

Protein-rRNA binding features and their structural and functional implications in ribosomes as determined by cross- linking studies.
Urlaub, H., Kruft, V., Bischof, O., Mueller, E.C. and Wittmann-Liebold, B.
EMBO Journal 14 (18): 4578-4588. 1 January 1995

1994

Activation of NF-kappaB in vivo is regulated by multiple phosphorylations.
Naumann, M. and Scheidereit, C.
EMBO Journal 13 (19): 4597-4607. 3 October 1994

Displacement of housekeeping proteasome subunits by MHC-encoded LMPs: a newly discovered mechanism for modulating the multicatalytic proteinase complex.
Fruh, K., Gossen, M., Wang, K., Bujard, H., Peterson, P.A. and Yang, Y.
EMBO Journal 13 : 3236-3244. 15 July 1994

Multimeric structure of ClC-1 chloride channel revealed by mutations in dominant myotonia congenita (Thomsen).
Steinmeyer, K., Lorenz, C., Pusch, M., Koch, M.C. and Jentsch, T.J.
EMBO Journal 13 (4): 737-743. 15 February 1994

Stress- and mitogen-induced phosphorylation of the small heat shock protein Hsp25 by MAPKAP kinase 2 is not essential for chaperone properties and cellular thermoresistance.
Knauf, U., Jakob, U., Engel, K., Buchner, J. and Gaestel, M.
EMBO Journal 13 : 54-60. 1 January 1994

Yeast chromosome III: new gene functions.
Koonin, E., Bork, P. and Sander, C.
EMBO Journal 13 : 493-503. 1 January 1994

Systematic probing of the environment of a translocating secretory protein during translocation through the ER membrane.
Mothes, W., Prehn, S. and Rapoport, T.A.
EMBO Journal 13 : 3973-3982. 1 January 1994

1993

Promoter analysis of the gene encoding the IkappaB-alpha/MAD3 inhibitor of NF-kappaB: positive regulation by members of the rel/NF-kappaB family.
Le Bail, O., Schmidt-Ullrich, R. and Israel, A.
EMBO Journal 12 (13): 5043-5049. 15 December 1993

Common structural constituents confer IkappaB activity to NF-kappaB p105 and IkappaB/MAD-3.
Hatada, E.N., Naumann, M. and Scheidereit, C.
EMBO Journal 12 (7): 2781-2788. July 1993

Unliganded T3R, but not its oncogenic variant, v-erbA, suppresses RAR-dependent transactivation by titrating out RXR.
Barettino, D., Bugge, T.H., Bartunek, P., Vivanco Ruiz, M.D., Sonntag-Buck, V., Beug, H., Zenke, M. and Stunnenberg, H.G.
EMBO Journal 12 (4): 1343-1354. April 1993

The NF-M transcription factor is related to C/EBP beta and plays a role in signal transduction, differentiation and leukemogenesis of avian myelomonocytic cells.
Katz, S., Kowenz-Leutz, E., Mueller, C., Meese, K., Ness, S.A. and Leutz, A.
EMBO Journal 12 (4): 1321-1332. April 1993

Caveolae and sorting in the trans-Golgi network of epithelial cells.
Dupree, P., Parton, R.G., Raposo, G., Kurzchalia, T.V. and Simons, K.
EMBO Journal 12 : 1597-1605. 1 January 1993

The NF-kappaB precursor p105 and the proto-oncogene product Bcl- 3 are I kappa B molecules and control nuclear translocation of NF-kappa B.
Naumann, M., Wulczyn, F.G. and Scheidereit, C.
EMBO Journal 12 (1): 213-222. January 1993

1992

Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor.
Naldini, L., Tamagnone, L., Vigna, E., Sachs, M., Hartmann, G., Birchmeier, W., Daikuhara, Y., Tsubouchi, H., Blasi, F. and Comoglio, P.M.
EMBO Journal 11 (13): 4825-4833. 1 December 1992

Identification of a negative regulatory domain in the human papillomavirus type 18 promoter: interaction with the transcriptional repressor YY1.
Bauknecht, T., Angel, P., Royer, H.D. and zur Hausen, H.
EMBO Journal 11 (12): 4607-4617. December 1992

Hormone-regulated v-rel estrogen receptor fusion protein: reversible induction of cell transformation and cellular gene expression.
Boehmelt, G., Walker, A., Kabrun, N., Mellitzer, G., Beug, H., Zenke, M. and Enrietto, P.J.
EMBO Journal 11 (12): 4641-4652. December 1992

The general mitochondrial processing peptidase from potato is an integral part of cytochrome c reductase of the respiratory chain.
Braun, H.P., Emmermann, M., Kruft, V. and Schmitz, U.K.
EMBO Journal 11 : 3219-3227. 1 January 1992

High blood pressure in transgenic mice carrying the rat angiotensinogen gene.
Kimura, S., Mullins, J.J., Jacob, H.J., Fuxe, K., Ganten, D. and Kaling, M.
EMBO Journal 11 : 821-827. 1 January 1992

Autocrine growth induced by kinase type oncogenes in myeloid cells requires AP-1 and NF-M, a myeloid specific, C/EBP-like factor.
Sterneck, E., Mueller, C., Katz, S. and Leutz, A.
EMBO Journal 11 (1): 115-126. January 1992

1988

Cyclic AMP-independent, dual regulation of voltage-dependent Ca2+ currents by LHRH and somatostatin in a pituitary cell line.
Rosenthal, W., Hescheler, J., Hinsch, K.D., Spicher, K., Trautwein, W. and Schultz, G.
EMBO Journal 7 (6): 1627-1633. June 1988

Angiotensin II-induced stimulation of voltage-dependent Ca2+ currents in an adrenal cortical cell line.
Hescheler, J., Rosenthal, W., Hinsch, K.D., Wulfern, M., Trautwein, W. and Schultz, G.
EMBO Journal 7 (3): 619-624. March 1988