Article

Small intestinal neuroendocrine tumors lack early genomic drivers, acquire DNA repair defects and harbor hallmarks of low REST expression.
Bolduan, F., Müller-Bötticher, N., Debnath, O. ORCID: https://orcid.org/0009-0009-2845-055X, Eichhorn, I., Giesecke, Y., Wetzel, A., Sahay, S., Zemojtel, T., Jaeger, M., Ungethuem, U., Roderburg, C., Kunze, C.A., Lehmann, A., Horst, D., Tacke, F., Eils, R., Wiedenmann, B., Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761 and Ishaque, N. ORCID: https://orcid.org/0000-0002-8426-901X
Scientific Reports 15 (1): 17969. 23 May 2025

Extrusion of BMP2+ surface colonocytes promotes stromal remodeling and tissue regeneration.
Heuberger, J. ORCID: https://orcid.org/0000-0001-7205-732X, Liu, L., Berger, H. ORCID: https://orcid.org/0000-0002-6304-4946, van den Heuvel, J., Lin, M. ORCID: https://orcid.org/0000-0003-4093-9277, Müllerke, S., Bayram, S. ORCID: https://orcid.org/0009-0009-5245-5473, Beccaceci, G. ORCID: https://orcid.org/0000-0002-6453-3725, de Jonge, H. ORCID: https://orcid.org/0000-0003-2777-4084, Gherardi, E. and Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761
Nature Communications 16 (1): 4131. 3 May 2025

Faecal cytolysin is associated with worse survival in patients with primary sclerosing cholangitis.
Özdirik, B., Berger, H., Tonetti, F.R., Cabré, N., Treichel, N., Clavel, T., Tacke, F. ORCID: https://orcid.org/0000-0001-6206-0226, Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761 and Schnabl, B. ORCID: https://orcid.org/0000-0002-6281-825X
Liver International 45 (4): e16181. April 2025

Persistent abdominal pain and diarrhea after appendectomy-Crohn's disease versus intestinal tuberculosis.
Wizenty, J., Maibier, M. and Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761
JGH Open 9 (4): e70157. April 2025

p53 terminates the regenerative fetal-like state after colitis-associated injury.
Hartl, K. ORCID: https://orcid.org/0000-0002-2965-0512, Bayram, Ş. ORCID: https://orcid.org/0009-0009-5245-5473, Wetzel, A., Harnack, C., Lin, M. ORCID: https://orcid.org/0000-0003-4093-9277, Fischer, A.S. ORCID: https://orcid.org/0000-0002-2176-1779, Liu, L. ORCID: https://orcid.org/0000-0002-9553-5475, Beccacec, G. ORCID: https://orcid.org/0000-0002-6453-3725, Mastrobuoni, G. ORCID: https://orcid.org/0000-0003-4509-1295, Geisberger, S. ORCID: https://orcid.org/0000-0001-6477-1312, Forbes, M. ORCID: https://orcid.org/0000-0001-7775-8352, Monteiro, B.J.E. ORCID: https://orcid.org/0000-0001-9718-2776, Macino, M. ORCID: https://orcid.org/0000-0002-8730-9005, Flores, R.E. ORCID: https://orcid.org/0000-0001-6500-8407, Engelmann, C., Mollenkopf, H.J. ORCID: https://orcid.org/0000-0003-1167-4783, Schupp, M. ORCID: https://orcid.org/0000-0003-3720-1052, Tacke, F. ORCID: https://orcid.org/0000-0001-6206-0226, Sanders, A.D. ORCID: https://orcid.org/0000-0003-3945-0677, Kempa, S. ORCID: https://orcid.org/0000-0002-0696-9299, Berger, H. ORCID: https://orcid.org/0000-0002-6304-4946 and Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761
Science Advances 10 (43): eadp8783. 25 October 2024

Long-term impact of scheduled regular endoscopic interventions for patients with primary sclerosing cholangitis.
Özdirik, B. ORCID: https://orcid.org/0000-0002-8885-737X, Veltzke-Schlieker, W., Nicklaus, J.M., Berger, H., Schmidt, D., Leonhardt, S., Penndorf, V., Adler, A., Müller, T., Wree, A., Tacke, F. and Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761
Hepatology Communications 8 (9): e0494. September 2024

Intestinal retinol saturase is implicated in the development of obesity and epithelial homeostasis upon injury.
Kiefer, M.F. ORCID: https://orcid.org/0000-0002-6344-2856, Meng, Y., Yang, N., Vahrenbrink, M., Wulff, S., Li, C., Wowro, S.J., Petricek, K.M., Sommerfeld, M., Flores, R.E., Obermayer, B. ORCID: https://orcid.org/0000-0002-9116-630X, Piepelow, K., Klaus, S., Hartl, K. ORCID: https://orcid.org/0000-0002-2965-0512, Guillot, A., Tacke, F., Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761 and Schupp, M.
American Journal of Physiology Endocrinology and Metabolism 327 (2): E203-E216. August 2024

Elevated sortilin expression discriminates functional from non-functional neuroendocrine tumors and enables therapeutic targeting.
Bolduan, F., Wetzel, A., Giesecke, Y., Eichhorn, I., Alenina, N. ORCID: https://orcid.org/0000-0002-6071-5433, Bader, M. ORCID: https://orcid.org/0000-0003-4780-4164, Willnow, T.E. ORCID: https://orcid.org/0000-0001-9515-7921, Wiedenmann, B. and Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761
Frontiers in Endocrinology 15 : 1331231. 17 April 2024

Gastric stem cell biology and helicobacter pylori infection.
Wizenty, J. and Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761
Current Topics in Microbiology and Immunology 444 : 1-24. 18 January 2024

Hepatobiliary long-term consequences of COVID-19: dramatically increased rate of secondary sclerosing cholangitis in critically ill COVID-19 patients.
Leonhardt, S., Jürgensen, C., Frohme, J., Grajecki, D., Adler, A., Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761, Leonhardt, J., Voll, J.M., Kruse, J.M., Körner, R., Eckardt, K.U., Janssen, H.J., Gebhardt, V., Schmittner, M.D., Frey, C., Müller-Ide, H., Bauer, M., Thibeault, C., Kurth, F., Sander, L.E., Müller, T. and Tacke, F.
Hepatology International 17 (6): 1610-1625. December 2023

A fucoidan plant drink reduces Helicobacter pylori load in the stomach: a real-world study.
Teng, Q.L., Sui, S.J., Zhu, Z., Gao, Q., Ge, H., Wang, K.Q., Lino-Silva, L.S., Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761, White, J.R., Peng, Q.H. and Wei, Y.Z.
Translational Gastroenterology and Hepatology 8 : 34-34. 30 October 2023

Association of helicobacter pylori positivity with risk of disease and mortality.
Wizenty, J., Koop, P.H., Clusmann, J., Tacke, F., Trautwein, C., Schneider, K.M., Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761 and Schneider, C.V.
Clinical and Translational Gastroenterology 14 (9): e00610. September 2023

Osteopontin is a prognostic circulating biomarker in patients with neuroendocrine neoplasms.
Kidess, E., Giesecke, Y., Eichhorn, I., Mohr, R., Jann, H., Fischer, C., Wiedenmann, B., Roderburg, C., Tacke, F. and Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761
Journal of Cancer Research and Clinical Oncology 149 (12): 10925-10933. September 2023

Short-term mucosal disruption enables colibactin-producing E. coli to cause long-term perturbation of colonic homeostasis.
Harnack, C., Berger, H., Liu, L., Mollenkopf, H.J., Strowig, T. and Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761
Gut Microbes 15 (1): 2233689. 10 July 2023

Synchrones Auftreten eines Adenokarzinoms und eines Non-Hodgkin B-Zell-Lymphoms bei einem Patienten mit einem variablen Immundefektsyndrom (CVID) [When malignancy hits twice - synchronous gastric carcinoma and non-Hodgkin-B-cell lymphoma in a patient with common variable immunodeficiency].
Krick, D., Hauptmann, K., Penndorf, V., Tacke, F., Krüger, R., von Bernuth, H. and Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761
Zeitschrift fur Gastroenterologie 61 (7): 827-831. July 2023

Biliary microbial patterns in primary sclerosing cholangitis are linked to poorer transplant-free survival.
Özdirik, B. ORCID: https://orcid.org/0000-0002-8885-737X, Scherf, M., Brumercek, A., Nicklaus, J.M., Kruis, T., Haber, P.K., Pratschke, J., Tacke, F. ORCID: https://orcid.org/0000-0001-6206-0226 and Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761
Hepatology Communications 7 (6): e0156. June 2023

Establishment of gastrointestinal assembloids to study the interplay between epithelial crypts and their mesenchymal niche.
Lin, M. ORCID: https://orcid.org/0000-0003-4093-9277, Hartl, K. ORCID: https://orcid.org/0000-0002-2965-0512, Heuberger, J. ORCID: https://orcid.org/0000-0001-7205-732X, Beccaceci, G. ORCID: https://orcid.org/0000-0002-6453-3725, Berger, H. ORCID: https://orcid.org/0000-0002-6304-4946, Li, H. ORCID: https://orcid.org/0000-0001-5677-3377, Liu, L. ORCID: https://orcid.org/0000-0002-9553-5475, Müllerke, S., Conrad, T. ORCID: https://orcid.org/0000-0001-5618-6295, Heymann, F., Woehler, A. ORCID: https://orcid.org/0000-0001-5157-9313, Tacke, F. ORCID: https://orcid.org/0000-0001-6206-0226, Rajewsky, N. ORCID: https://orcid.org/0000-0002-4785-4332 and Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761
Nature Communications 14 (1): 3025. 25 May 2023

R-spondin-YAP axis promotes gastric oxyntic gland regeneration and Helicobacter pylori-associated metaplasia in mice.
Fischer, A.S. ORCID: https://orcid.org/0000-0002-2176-1779, Müllerke, S., Arnold, A., Heuberger, J. ORCID: https://orcid.org/0000-0001-7205-732X, Berger, H., Lin, M. ORCID: https://orcid.org/0000-0003-4093-9277, Mollenkopf, H.J. ORCID: https://orcid.org/0000-0003-1167-4783, Wizenty, J. ORCID: https://orcid.org/0000-0003-4261-0416, Horst, D. ORCID: https://orcid.org/0000-0003-4755-5743, Tacke, F. ORCID: https://orcid.org/0000-0001-6206-0226 and Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761
Journal of Clinical Investigation 132 (21): e151363. 1 November 2022

Gastric stem cells promote inflammation and gland remodeling in response to Helicobacter pylori via Rspo3-Lgr4 axis.
Wizenty, J. ORCID: https://orcid.org/0000-0003-4261-0416, Müllerke, S., Kolesnichenko, M. ORCID: https://orcid.org/0000-0001-7366-9061, Heuberger, J. ORCID: https://orcid.org/0000-0001-7205-732X, Lin, M. ORCID: https://orcid.org/0000-0003-4093-9277, Fischer, A.S. ORCID: https://orcid.org/0000-0002-2176-1779, Mollenkopf, H.J., Berger, H., Tacke, F. ORCID: https://orcid.org/0000-0001-6206-0226 and Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761
EMBO Journal 41 (13): e109996. 4 July 2022

Soluble urokinase plasminogen activator receptor levels are associated with severity of fibrosis in patients with primary sclerosing cholangitis.
Özdirik, B. ORCID: https://orcid.org/0000-0002-8885-737X, Maibier, M., Scherf, M., Nicklaus, J.M., Frohme, J., Puengel, T. ORCID: https://orcid.org/0000-0003-2662-6127, Meyer Zum Büschenfelde, D., Tacke, F. ORCID: https://orcid.org/0000-0001-6206-0226, Mueller, T. ORCID: https://orcid.org/0000-0003-3426-5421 and Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761
Journal of Clinical Medicine 11 (9): 2479. 28 April 2022

Epigenetic modifier balances Mapk and Wnt signalling in differentiation of goblet and Paneth cells.
Grinat, J. ORCID: https://orcid.org/0000-0003-0152-4941, Kosel, F., Goveas, N. ORCID: https://orcid.org/0000-0002-2531-5514, Kranz, A. ORCID: https://orcid.org/0000-0002-7481-0220, Alexopoulou, D. ORCID: https://orcid.org/0000-0002-3715-1756, Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370, Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761, Stewart, A.F. and Heuberger, J. ORCID: https://orcid.org/0000-0001-7205-732X
Life Science Alliance 5 (4): e202101187. April 2022

Stem cells, helicobacter pylori and mutational landscape: utility of preclinical models to understand carcinogenesis and to direct management of gastric cancer.
Liabeuf, D., Oshima, M., Stange, D.E. and Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761
Gastroenterology 162 (4): 1067-1087. April 2022

BMP feed-forward loop promotes terminal differentiation in gastric glands and is interrupted by H. pylori-driven inflammation.
Kapalczynska, M., Lin, M. ORCID: https://orcid.org/0000-0003-4093-9277, Maertzdorf, J., Heuberger, J. ORCID: https://orcid.org/0000-0001-7205-732X, Muellerke, S., Zuo, X. ORCID: https://orcid.org/0000-0002-8593-1132, Vidal, R. ORCID: https://orcid.org/0000-0003-4217-2014, Shureiqi, I. ORCID: https://orcid.org/0000-0003-2019-938X, Fischer, A.S. ORCID: https://orcid.org/0000-0002-2176-1779, Sauer, S. ORCID: https://orcid.org/0000-0002-4794-3693, Berger, H. ORCID: https://orcid.org/0000-0002-6304-4946, Kidess, E., Mollenkopf, H.J. ORCID: https://orcid.org/0000-0003-1167-4783, Tacke, F. ORCID: https://orcid.org/0000-0001-6206-0226, Meyer, T.F. ORCID: https://orcid.org/0000-0002-6120-8679 and Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761
Nature Communications 13 (1): 1577. 24 March 2022

S100A4 is a strong negative prognostic marker and potential therapeutic target in adenocarcinoma of the stomach and esophagus.
Treese, C. ORCID: https://orcid.org/0000-0001-9120-6773, Hartl, K. ORCID: https://orcid.org/0000-0002-2965-0512, Pötzsch, M., Dahlmann, M. ORCID: https://orcid.org/0000-0002-0036-5283, von Winterfeld, M., Berg, E., Hummel, M., Timm, L., Rau, B. ORCID: https://orcid.org/0000-0001-5820-6907, Walther, W. ORCID: https://orcid.org/0000-0003-2884-0231, Daum, S. ORCID: https://orcid.org/0000-0003-0060-6013, Kobelt, D. ORCID: https://orcid.org/0000-0002-9373-0648 and Stein, U. ORCID: https://orcid.org/0000-0001-7006-282X
Cells 11 (6): 1056. 21 March 2022

Helicobacter pylori - neue Aspekte kommender Leitlinien [Helicobacter pylori - new aspects of forthcoming guidelines].
Schulz, C., Fischbach, W., Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761, Schütte, K., Suerbaum, S. and Malfertheiner, P.
Internist 63 (4): 367-371. 1 March 2022

Elevated Flt3L predicts long-term survival in patients with high-grade gastroenteropancreatic neuroendocrine neoplasms.
Detjen, K.M., Otto, R. ORCID: https://orcid.org/0000-0003-3644-743X, Giesecke, Y., Geisler, L., Riemer, P., Jann, H., Grötzinger, C. ORCID: https://orcid.org/0000-0001-9872-3087, Sers, C., Pascher, A., Lüdde, T., Leser, U., Wiedenmann, B., Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761, Tacke, F. ORCID: https://orcid.org/0000-0001-6206-0226, Roderburg, C. and Hammerich, L. ORCID: https://orcid.org/0000-0003-0557-3927
Cancers 13 (17): 4463. 1 September 2021

High Yap and Mll1 promote a persistent regenerative cell state induced by Notch signaling and loss of p53.
Heuberger, J. ORCID: https://orcid.org/0000-0001-7205-732X, Grinat, J. ORCID: https://orcid.org/0000-0003-0152-4941, Kosel, F., Liu, L., Kunz, S. ORCID: https://orcid.org/0000-0002-0131-3506, Vidal, R.O. ORCID: https://orcid.org/0000-0003-4217-2014, Keil, M. ORCID: https://orcid.org/0000-0002-6009-9845, Haybaeck, J. ORCID: https://orcid.org/0000-0001-5518-3359, Robine, S. ORCID: https://orcid.org/0000-0002-8885-0389, Louvard, D. ORCID: https://orcid.org/0000-0001-5956-7755, Regenbrecht, C. ORCID: https://orcid.org/0000-0001-9494-5977, Sporbert, A. ORCID: https://orcid.org/0000-0002-3738-1295, Sauer, S. ORCID: https://orcid.org/0000-0002-4794-3693, von Eyss, B. ORCID: https://orcid.org/0000-0002-4731-6841, Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761 and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Proceedings of the National Academy of Sciences of the United States of America 118 (22): e2019699118. 1 June 2021

Health workforce response to Covid-19: What pandemic preparedness planning and action at the federal and state levels in Germany? Germany's health workforce responses to Covid-19.
Köppen, J. ORCID: https://orcid.org/0000-0001-7941-641X, Hartl, K. ORCID: https://orcid.org/0000-0002-2965-0512 and Maier, C.B. ORCID: https://orcid.org/0000-0002-7734-2258
International Journal of Health Planning and Management 36 (S1): 71-91. May 2021

Epithelial response to IFN-γ promotes SARS-CoV-2 infection.
Heuberger, J. ORCID: https://orcid.org/0000-0001-7205-732X, Trimpert, J., Vladimirova, D., Goosmann, C., Lin, M. ORCID: https://orcid.org/0000-0003-4093-9277, Schmuck, R., Mollenkopf, H.J., Brinkmann, V., Tacke, F., Osterrieder, N. and Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761
EMBO Molecular Medicine 13 (4): e13191. 9 April 2021

Defence and adaptation mechanisms of the intestinal epithelium upon infection.
Iftekhar, A. ORCID: https://orcid.org/0000-0002-0001-5590 and Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761
International Journal of Medical Microbiology 311 (3): 151486. April 2021

Genomic aberrations after short-term exposure to colibactin-producing E. coli transform primary colon epithelial cells.
Iftekhar, A. ORCID: https://orcid.org/0000-0002-0001-5590, Berger, H. ORCID: https://orcid.org/0000-0002-6304-4946, Bouznad, N., Heuberger, J. ORCID: https://orcid.org/0000-0001-7205-732X, Boccellato, F. ORCID: https://orcid.org/0000-0001-6013-7154, Dobrindt, U., Hermeking, H., Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761 and Meyer, T.F. ORCID: https://orcid.org/0000-0002-6120-8679
Nature Communications 12 (1): 1003. 12 February 2021

R-spondin 3 promotes stem cell recovery and epithelial regeneration in the colon.
Harnack, C. ORCID: https://orcid.org/0000-0003-0067-4921, Berger, H. ORCID: https://orcid.org/0000-0002-6304-4946, Antanaviciute, A. ORCID: https://orcid.org/0000-0002-9019-2215, Vidal, R. ORCID: https://orcid.org/0000-0003-4217-2014, Sauer, S. ORCID: https://orcid.org/0000-0002-4794-3693, Simmons, A., Meyer, T.F. ORCID: https://orcid.org/0000-0002-6120-8679 and Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761
Nature Communications 10 (1): 4368. 25 September 2019

R-spondin-3 induces secretory, antimicrobial Lgr5(+) cells in the stomach.
Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761, Del Mar Reinés, M., Müllerke, S., Fischer, C. ORCID: https://orcid.org/0000-0003-0329-2435, Kapalczynska, M., Berger, H. ORCID: https://orcid.org/0000-0002-6304-4946, Bakker, E.R.M., Mollenkopf, H.J. ORCID: https://orcid.org/0000-0003-1167-4783, Rothenberg, M.E., Wiedenmann, B., Sauer, S. ORCID: https://orcid.org/0000-0002-4794-3693 and Meyer, T.F. ORCID: https://orcid.org/0000-0002-6120-8679
Nature Cell Biology 21 (7): 812-823. July 2019

Helicobacter pylori depletes cholesterol in gastric glands to prevent interferon gamma signaling and escape the inflammatory response.
Morey, P., Pfannkuch, L., Pang, E., Boccellato, F., Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761, Imai-Matsushima, A., Dyer, V., Koch, M., Mollenkopf, H.J., Schlaermann, P. and Meyer, T.F.
Gastroenterology 154 (5): 1391-1404. April 2018

Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis.
Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761, Logan, C.Y., Kapalczynska, M., Mollenkopf, H.J., Berger, H., Wiedenmann, B., Nusse, R., Amieva, M.R. and Meyer, T.F.
Nature 548 (7668): 451-455. 24 August 2017

Quantitative imaging of gut microbiota spatial organization.
Earle, K.A., Billings, G., Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761, Lichtman, J.S., Hansson, G.C., Elias, J.E., Amieva, M.R., Huang, K.C. and Sonnenburg, J.L.
Cell Host & Microbe 18 (4): 478-488. 14 October 2015

Chemodetection and destruction of host urea allows Helicobacter pylori to locate the epithelium.
Huang, J.Y., Sweeney Goers, E., Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761, Zhang, H.C., Remington, S.J., Cantrell, M.A., Kuo, C.J., Guillemin, K. and Amieva, M.R.
Cell Host & Microbe 18 (2): 147-156. 12 August 2015

Helicobacter pylori activates and expands Lgr5(+) stem cells through direct colonization of the gastric glands.
Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761, Rothenberg, M.E., Logan, C.Y., Lee, J.Y., Honaker, R.W., Cooper, R.L., Passarelli, B., Camorlinga, M., Bouley, D.M., Alvarez, G., Nusse, R., Torres, J. and Amieva, M.R.
Gastroenterology 148 (7): 1392-1404. June 2015

Hepatoprotection in bile duct ligated mice mediated by darbepoetin-α is not caused by changes in hepatobiliary transporter expression.
Eipel, C., Menschikow, E., Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761, Kuhla, A., Abshagen, K. and Vollmar, B.
International Journal of Clinical and Experimental Pathology 6 (1): 80-90. 1 January 2013

Neuroendokrine Neoplasien des gastroenteropankreatischen Systems [Gastroenteropancreatic neuro-endocrine neoplasms].
Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761, Pape, F. and Wiedenmann, B.
Therapeutische Umschau 69 (10): 591-596. October 2012

Darbepoetin-α inhibits the perpetuation of necro-inflammation and delays the progression of cholestatic fibrosis in mice.
Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761, Siebert, N., Zechner, D. ORCID: https://orcid.org/0000-0002-2075-7540, Menschikow, E., Abshagen, K., Vollmar, B. and Eipel, C.
Laboratory Investigation 90 (10): 1447-1456. October 2010

Book Section

Microbiome and diseases: colorectal cancer.
Iftekhar, A., Sperlich, A., Janssen, K.P. and Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761
In: The Gut Microbiome in Health and Disease. Springer, Cham, 231-249. ISBN 978-3-319-90544-0 2018

Darbepoetin-α verringert die Nekroinflammation und mildert die cholestatische Fibrose in Mäusen [Darbepoetin-alpha inhibits the perpetuation of necro-inflammation and attenuates cholestatic fibrosis in mice].
Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761, Siebert, N., Abshagen, K., Vollmar, B. and Eipel, C.
In: Chirurgisches Forum und DGAV Forum 2010. Deutsche Gesellschaft für Chirurgie, 39 . Springer, Berlin, Heidelberg, 203-205. ISBN 978-3-642-12191-3 2010

Review

Defining the mucosal ecosystem: epithelial–mesenchymal interdependence in gastrointestinal health and disease.
England, Frances J., Lin, Manqiang ORCID: https://orcid.org/0000-0003-4093-9277, Sigal, Michael ORCID: https://orcid.org/0000-0003-4772-0761 and Leedham, Simon J.
Nature Reviews Gastroenterology & Hepatology 22 (11): 741-754. November 2025

Helicobacter pylori, microbiota and gastric cancer - principles of microorganism-driven carcinogenesis.
Wizenty, J. ORCID: https://orcid.org/0000-0003-4261-0416 and Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761
Nature Reviews Gastroenterology & Hepatology 22 (5): 296-313. May 2025

Role of intestinal barrier disruption to acute-on-chronic liver failure.
Pohl, J., Aretakis, D., Tacke, F., Engelmann, C. and Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761
Seminars in Liver Disease 45 (1): 52-65. March 2025

Unwelcome guests – the role of gland-associated Helicobacter pylori infection in gastric carcinogenesis.
Beccaceci, G. ORCID: https://orcid.org/0000-0002-6453-3725 and Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761
Frontiers in Oncology 13 : 1171003. 21 April 2023

The role of microbiota in primary sclerosing cholangitis and related biliary malignancies.
Özdirik, B. ORCID: https://orcid.org/0000-0002-8885-737X, Müller, T. ORCID: https://orcid.org/0000-0003-3426-5421, Wree, A., Tacke, F. ORCID: https://orcid.org/0000-0001-6206-0226 and Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761
International Journal of Molecular Sciences 22 (13): 6975. 1 July 2021

Microbe-driven genotoxicity in gastrointestinal carcinogenesis.
Hartl, K. ORCID: https://orcid.org/0000-0002-2965-0512 and Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761
International Journal of Molecular Sciences 21 (20): 7439. 2 October 2020

Responses of gastric epithelial stem cells and their niche to Helicobacter pylori infection.
Wizenty, J., Tacke, F. and Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761
Annals of Translational Medicine 8 (8): 568. April 2020

The role of Wnt and R-spondin in the stomach during health and disease.
Fischer, A.S. ORCID: https://orcid.org/0000-0002-2176-1779 and Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761
Biomedicines 7 (2): 44. 19 June 2019

Coevolution between the human microbiota and the epithelial immune system.
Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761 and Meyer, T.F.
Digestive Diseases 34 (3): 190-193. March 2016

Editorial

Human embryo models: unveiling sophisticated self-organization of stem cells during post-implantation stages.
Lin, M. ORCID: https://orcid.org/0000-0003-4093-9277 and Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761
Signal Transduction and Targeted Therapy 8 (1): 419. 6 November 2023

Mucosa-associated microbiota alterations in primary sclerosing cholangitis (PSC) before and after liver transplantation—who is calling the shots?
Demir, M. and Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761
Hepatobiliary Surgery and Nutrition 12 (5): 795-797. 1 October 2023

Wie das Immunsystem SARS-CoV-2 den Weg ebnet [How the immune system paves the way for SARS-CoV-2].
Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761
Hygiene und Medizin 46 (3): 22-23. 2021