Browse by Research Team

2024

p53 terminates the regenerative fetal-like state after colitis-associated injury.
Hartl, K., Bayram, Ş., Wetzel, A., Harnack, C., Lin, M., Fischer, A.S., Liu, L., Beccacec, G., Mastrobuoni, G., Geisberger, S., Forbes, M., Monteiro, B.J.E., Macino, M., Flores, R.E., Engelmann, C., Mollenkopf, H.J., Schupp, M., Tacke, F., Sanders, A.D., Kempa, S., Berger, H. and Sigal, M.
Science Advances 10 (43): eadp8783. 25 October 2024

Long-term impact of scheduled regular endoscopic interventions for patients with primary sclerosing cholangitis.
Özdirik, B., Veltzke-Schlieker, W., Nicklaus, J.M., Berger, H., Schmidt, D., Leonhardt, S., Penndorf, V., Adler, A., Müller, T., Wree, A., Tacke, F. and Sigal, M.
Hepatology Communications 8 (9): e0494. September 2024

Intestinal retinol saturase is implicated in the development of obesity and epithelial homeostasis upon injury.
Kiefer, M.F., Meng, Y., Yang, N., Vahrenbrink, M., Wulff, S., Li, C., Wowro, S.J., Petricek, K.M., Sommerfeld, M., Flores, R.E., Obermayer, B., Piepelow, K., Klaus, S., Hartl, K., Guillot, A., Tacke, F., Sigal, M. and Schupp, M.
American Journal of Physiology Endocrinology and Metabolism 327 (2): E203-E216. August 2024

Elevated sortilin expression discriminates functional from non-functional neuroendocrine tumors and enables therapeutic targeting.
Bolduan, F., Wetzel, A., Giesecke, Y., Eichhorn, I., Alenina, N., Bader, M., Willnow, T.E., Wiedenmann, B. and Sigal, M.
Frontiers in Endocrinology 15 : 1331231. 17 April 2024

Gastric stem cell biology and helicobacter pylori infection.
Wizenty, J. and Sigal, M.
Current Topics in Microbiology and Immunology 444 : 1-24. 18 January 2024

2023

Hepatobiliary long-term consequences of COVID-19: dramatically increased rate of secondary sclerosing cholangitis in critically ill COVID-19 patients.
Leonhardt, S., Jürgensen, C., Frohme, J., Grajecki, D., Adler, A., Sigal, M., Leonhardt, J., Voll, J.M., Kruse, J.M., Körner, R., Eckardt, K.U., Janssen, H.J., Gebhardt, V., Schmittner, M.D., Frey, C., Müller-Ide, H., Bauer, M., Thibeault, C., Kurth, F., Sander, L.E., Müller, T. and Tacke, F.
Hepatology International 17 (6): 1610-1625. December 2023

Human embryo models: unveiling sophisticated self-organization of stem cells during post-implantation stages.
Lin, M. and Sigal, M.
Signal Transduction and Targeted Therapy 8 (1): 419. 6 November 2023

A fucoidan plant drink reduces Helicobacter pylori load in the stomach: a real-world study.
Teng, Q.L., Sui, S.J., Zhu, Z., Gao, Q., Ge, H., Wang, K.Q., Lino-Silva, L.S., Sigal, M., White, J.R., Peng, Q.H. and Wei, Y.Z.
Translational Gastroenterology and Hepatology 8 : 34-34. 30 October 2023

Mucosa-associated microbiota alterations in primary sclerosing cholangitis (PSC) before and after liver transplantation—who is calling the shots?
Demir, M. and Sigal, M.
Hepatobiliary Surgery and Nutrition 12 (5): 795-797. 1 October 2023

Association of helicobacter pylori positivity with risk of disease and mortality.
Wizenty, J., Koop, P.H., Clusmann, J., Tacke, F., Trautwein, C., Schneider, K.M., Sigal, M. and Schneider, C.V.
Clinical and Translational Gastroenterology 14 (9): e00610. September 2023

Osteopontin is a prognostic circulating biomarker in patients with neuroendocrine neoplasms.
Kidess, E., Giesecke, Y., Eichhorn, I., Mohr, R., Jann, H., Fischer, C., Wiedenmann, B., Roderburg, C., Tacke, F. and Sigal, M.
Journal of Cancer Research and Clinical Oncology 149 (12): 10925-10933. September 2023

Short-term mucosal disruption enables colibactin-producing E. coli to cause long-term perturbation of colonic homeostasis.
Harnack, C., Berger, H., Liu, L., Mollenkopf, H.J., Strowig, T. and Sigal, M.
Gut Microbes 15 (1): 2233689. 10 July 2023

Synchrones Auftreten eines Adenokarzinoms und eines Non-Hodgkin B-Zell-Lymphoms bei einem Patienten mit einem variablen Immundefektsyndrom (CVID) [When malignancy hits twice - synchronous gastric carcinoma and non-Hodgkin-B-cell lymphoma in a patient with common variable immunodeficiency].
Krick, D., Hauptmann, K., Penndorf, V., Tacke, F., Krüger, R., von Bernuth, H. and Sigal, M.
Zeitschrift fur Gastroenterologie 61 (7): 827-831. July 2023

Biliary microbial patterns in primary sclerosing cholangitis are linked to poorer transplant-free survival.
Özdirik, B., Scherf, M., Brumercek, A., Nicklaus, J.M., Kruis, T., Haber, P.K., Pratschke, J., Tacke, F. and Sigal, M.
Hepatology Communications 7 (6): e0156. June 2023

Establishment of gastrointestinal assembloids to study the interplay between epithelial crypts and their mesenchymal niche.
Lin, M., Hartl, K., Heuberger, J., Beccaceci, G., Berger, H., Li, H., Liu, L., Müllerke, S., Conrad, T., Heymann, F., Woehler, A., Tacke, F., Rajewsky, N. and Sigal, M.
Nature Communications 14 (1): 3025. 25 May 2023

Unwelcome guests – the role of gland-associated Helicobacter pylori infection in gastric carcinogenesis.
Beccaceci, G. and Sigal, M.
Frontiers in Oncology 13 : 1171003. 21 April 2023

2022

R-spondin-YAP axis promotes gastric oxyntic gland regeneration and Helicobacter pylori-associated metaplasia in mice.
Fischer, A.S., Müllerke, S., Arnold, A., Heuberger, J., Berger, H., Lin, M., Mollenkopf, H.J., Wizenty, J., Horst, D., Tacke, F. and Sigal, M.
Journal of Clinical Investigation 132 (21): e151363. 1 November 2022

Gastric stem cells promote inflammation and gland remodeling in response to Helicobacter pylori via Rspo3-Lgr4 axis.
Wizenty, J., Müllerke, S., Kolesnichenko, M., Heuberger, J., Lin, M., Fischer, A.S., Mollenkopf, H.J., Berger, H., Tacke, F. and Sigal, M.
EMBO Journal 41 (13): e109996. 4 July 2022

Soluble urokinase plasminogen activator receptor levels are associated with severity of fibrosis in patients with primary sclerosing cholangitis.
Özdirik, B., Maibier, M., Scherf, M., Nicklaus, J.M., Frohme, J., Puengel, T., Meyer Zum Büschenfelde, D., Tacke, F., Mueller, T. and Sigal, M.
Journal of Clinical Medicine 11 (9): 2479. 28 April 2022

Epigenetic modifier balances Mapk and Wnt signalling in differentiation of goblet and Paneth cells.
Grinat, J., Kosel, F., Goveas, N., Kranz, A., Alexopoulou, D., Rajewsky, K., Sigal, M., Stewart, A.F. and Heuberger, J.
Life Science Alliance 5 (4): e202101187. April 2022

Stem cells, helicobacter pylori and mutational landscape: utility of preclinical models to understand carcinogenesis and to direct management of gastric cancer.
Liabeuf, D., Oshima, M., Stange, D.E. and Sigal, M.
Gastroenterology 162 (4): 1067-1087. April 2022

BMP feed-forward loop promotes terminal differentiation in gastric glands and is interrupted by H. pylori-driven inflammation.
Kapalczynska, M., Lin, M., Maertzdorf, J., Heuberger, J., Muellerke, S., Zuo, X., Vidal, R., Shureiqi, I., Fischer, A.S., Sauer, S., Berger, H., Kidess, E., Mollenkopf, H.J., Tacke, F., Meyer, T.F. and Sigal, M.
Nature Communications 13 (1): 1577. 24 March 2022

S100A4 is a strong negative prognostic marker and potential therapeutic target in adenocarcinoma of the stomach and esophagus.
Treese, C., Hartl, K., Pötzsch, M., Dahlmann, M., von Winterfeld, M., Berg, E., Hummel, M., Timm, L., Rau, B., Walther, W., Daum, S., Kobelt, D. and Stein, U.
Cells 11 (6): 1056. 21 March 2022

Helicobacter pylori - neue Aspekte kommender Leitlinien [Helicobacter pylori - new aspects of forthcoming guidelines].
Schulz, C., Fischbach, W., Sigal, M., Schütte, K., Suerbaum, S. and Malfertheiner, P.
Internist 63 (4): 367-371. 1 March 2022

2021

Elevated Flt3L predicts long-term survival in patients with high-grade gastroenteropancreatic neuroendocrine neoplasms.
Detjen, K.M., Otto, R., Giesecke, Y., Geisler, L., Riemer, P., Jann, H., Grötzinger, C., Sers, C., Pascher, A., Lüdde, T., Leser, U., Wiedenmann, B., Sigal, M., Tacke, F., Roderburg, C. and Hammerich, L.
Cancers 13 (17): 4463. 1 September 2021

The role of microbiota in primary sclerosing cholangitis and related biliary malignancies.
Özdirik, B., Müller, T., Wree, A., Tacke, F. and Sigal, M.
International Journal of Molecular Sciences 22 (13): 6975. 1 July 2021

High Yap and Mll1 promote a persistent regenerative cell state induced by Notch signaling and loss of p53.
Heuberger, J., Grinat, J., Kosel, F., Liu, L., Kunz, S., Vidal, R.O., Keil, M., Haybaeck, J., Robine, S., Louvard, D., Regenbrecht, C., Sporbert, A., Sauer, S., von Eyss, B., Sigal, M. and Birchmeier, W.
Proceedings of the National Academy of Sciences of the United States of America 118 (22): e2019699118. 1 June 2021

Health workforce response to Covid-19: What pandemic preparedness planning and action at the federal and state levels in Germany? Germany's health workforce responses to Covid-19.
Köppen, J., Hartl, K. and Maier, C.B.
International Journal of Health Planning and Management 36 (S1): 71-91. May 2021

Epithelial response to IFN-γ promotes SARS-CoV-2 infection.
Heuberger, J., Trimpert, J., Vladimirova, D., Goosmann, C., Lin, M., Schmuck, R., Mollenkopf, H.J., Brinkmann, V., Tacke, F., Osterrieder, N. and Sigal, M.
EMBO Molecular Medicine 13 (4): e13191. 9 April 2021

Defence and adaptation mechanisms of the intestinal epithelium upon infection.
Iftekhar, A. and Sigal, M.
International Journal of Medical Microbiology 311 (3): 151486. April 2021

Genomic aberrations after short-term exposure to colibactin-producing E. coli transform primary colon epithelial cells.
Iftekhar, A., Berger, H., Bouznad, N., Heuberger, J., Boccellato, F., Dobrindt, U., Hermeking, H., Sigal, M. and Meyer, T.F.
Nature Communications 12 (1): 1003. 12 February 2021

Wie das Immunsystem SARS-CoV-2 den Weg ebnet [How the immune system paves the way for SARS-CoV-2].
Sigal, M.
Hygiene und Medizin 46 (3): 22-23. 2021

2020

Microbe-driven genotoxicity in gastrointestinal carcinogenesis.
Hartl, K. and Sigal, M.
International Journal of Molecular Sciences 21 (20): 7439. 2 October 2020

Responses of gastric epithelial stem cells and their niche to Helicobacter pylori infection.
Wizenty, J., Tacke, F. and Sigal, M.
Annals of Translational Medicine 8 (8): 568. April 2020

2019

R-spondin 3 promotes stem cell recovery and epithelial regeneration in the colon.
Harnack, C., Berger, H., Antanaviciute, A., Vidal, R., Sauer, S., Simmons, A., Meyer, T.F. and Sigal, M.
Nature Communications 10 (1): 4368. 25 September 2019

R-spondin-3 induces secretory, antimicrobial Lgr5(+) cells in the stomach.
Sigal, M., Del Mar Reinés, M., Müllerke, S., Fischer, C., Kapalczynska, M., Berger, H., Bakker, E.R.M., Mollenkopf, H.J., Rothenberg, M.E., Wiedenmann, B., Sauer, S. and Meyer, T.F.
Nature Cell Biology 21 (7): 812-823. July 2019

The role of Wnt and R-spondin in the stomach during health and disease.
Fischer, A.S. and Sigal, M.
Biomedicines 7 (2): 44. 19 June 2019

2018

Helicobacter pylori depletes cholesterol in gastric glands to prevent interferon gamma signaling and escape the inflammatory response.
Morey, P., Pfannkuch, L., Pang, E., Boccellato, F., Sigal, M., Imai-Matsushima, A., Dyer, V., Koch, M., Mollenkopf, H.J., Schlaermann, P. and Meyer, T.F.
Gastroenterology 154 (5): 1391-1404. April 2018

Microbiome and diseases: colorectal cancer.
Iftekhar, A., Sperlich, A., Janssen, K.P. and Sigal, M.
In: The Gut Microbiome in Health and Disease. Springer, Cham, 231-249. ISBN 978-3-319-90544-0 2018

2017

Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis.
Sigal, M., Logan, C.Y., Kapalczynska, M., Mollenkopf, H.J., Berger, H., Wiedenmann, B., Nusse, R., Amieva, M.R. and Meyer, T.F.
Nature 548 (7668): 451-455. 24 August 2017

2016

Coevolution between the human microbiota and the epithelial immune system.
Sigal, M. and Meyer, T.F.
Digestive Diseases 34 (3): 190-193. March 2016

2015

Quantitative imaging of gut microbiota spatial organization.
Earle, K.A., Billings, G., Sigal, M., Lichtman, J.S., Hansson, G.C., Elias, J.E., Amieva, M.R., Huang, K.C. and Sonnenburg, J.L.
Cell Host & Microbe 18 (4): 478-488. 14 October 2015

Chemodetection and destruction of host urea allows Helicobacter pylori to locate the epithelium.
Huang, J.Y., Sweeney Goers, E., Sigal, M., Zhang, H.C., Remington, S.J., Cantrell, M.A., Kuo, C.J., Guillemin, K. and Amieva, M.R.
Cell Host & Microbe 18 (2): 147-156. 12 August 2015

Helicobacter pylori activates and expands Lgr5(+) stem cells through direct colonization of the gastric glands.
Sigal, M., Rothenberg, M.E., Logan, C.Y., Lee, J.Y., Honaker, R.W., Cooper, R.L., Passarelli, B., Camorlinga, M., Bouley, D.M., Alvarez, G., Nusse, R., Torres, J. and Amieva, M.R.
Gastroenterology 148 (7): 1392-1404. June 2015

2013

Hepatoprotection in bile duct ligated mice mediated by darbepoetin-α is not caused by changes in hepatobiliary transporter expression.
Eipel, C., Menschikow, E., Sigal, M., Kuhla, A., Abshagen, K. and Vollmar, B.
International Journal of Clinical and Experimental Pathology 6 (1): 80-90. 1 January 2013

2012

Neuroendokrine Neoplasien des gastroenteropankreatischen Systems [Gastroenteropancreatic neuro-endocrine neoplasms].
Sigal, M., Pape, F. and Wiedenmann, B.
Therapeutische Umschau 69 (10): 591-596. October 2012

2010

Darbepoetin-α inhibits the perpetuation of necro-inflammation and delays the progression of cholestatic fibrosis in mice.
Sigal, M., Siebert, N., Zechner, D., Menschikow, E., Abshagen, K., Vollmar, B. and Eipel, C.
Laboratory Investigation 90 (10): 1447-1456. October 2010

Darbepoetin-α verringert die Nekroinflammation und mildert die cholestatische Fibrose in Mäusen [Darbepoetin-alpha inhibits the perpetuation of necro-inflammation and attenuates cholestatic fibrosis in mice].
Sigal, M., Siebert, N., Abshagen, K., Vollmar, B. and Eipel, C.
In: Chirurgisches Forum und DGAV Forum 2010. Deutsche Gesellschaft für Chirurgie, 39 . Springer, Berlin, Heidelberg, 203-205. ISBN 978-3-642-12191-3 2010