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Gastric stem cell biology and helicobacter pylori infection.
Wizenty, J. and Sigal, M.
Current Topics in Microbiology and Immunology 444 : 1-24. 18 January 2024


Hepatobiliary long-term consequences of COVID-19: dramatically increased rate of secondary sclerosing cholangitis in critically ill COVID-19 patients.
Leonhardt, S. and Jürgensen, C. and Frohme, J. and Grajecki, D. and Adler, A. and Sigal, M. and Leonhardt, J. and Voll, J.M. and Kruse, J.M. and Körner, R. and Eckardt, K.U. and Janssen, H.J. and Gebhardt, V. and Schmittner, M.D. and Frey, C. and Müller-Ide, H. and Bauer, M. and Thibeault, C. and Kurth, F. and Sander, L.E. and Müller, T. and Tacke, F.
Hepatology International 17 (6): 1610-1625. December 2023

Human embryo models: unveiling sophisticated self-organization of stem cells during post-implantation stages.
Lin, M. and Sigal, M.
Signal Transduction and Targeted Therapy 8 (1): 419. 6 November 2023

A fucoidan plant drink reduces Helicobacter pylori load in the stomach: a real-world study.
Teng, Q.L. and Sui, S.J. and Zhu, Z. and Gao, Q. and Ge, H. and Wang, K.Q. and Lino-Silva, L.S. and Sigal, M. and White, J.R. and Peng, Q.H. and Wei, Y.Z.
Translational Gastroenterology and Hepatology 8 : 34-34. 30 October 2023

Mucosa-associated microbiota alterations in primary sclerosing cholangitis (PSC) before and after liver transplantation—who is calling the shots?
Demir, M. and Sigal, M.
Hepatobiliary Surgery and Nutrition 12 (5): 795-797. 1 October 2023

Association of helicobacter pylori positivity with risk of disease and mortality.
Wizenty, J. and Koop, P.H. and Clusmann, J. and Tacke, F. and Trautwein, C. and Schneider, K.M. and Sigal, M. and Schneider, C.V.
Clinical and Translational Gastroenterology 14 (9): e00610. September 2023

Osteopontin is a prognostic circulating biomarker in patients with neuroendocrine neoplasms.
Kidess, E. and Giesecke, Y. and Eichhorn, I. and Mohr, R. and Jann, H. and Fischer, C. and Wiedenmann, B. and Roderburg, C. and Tacke, F. and Sigal, M.
Journal of Cancer Research and Clinical Oncology 149 (12): 10925-10933. September 2023

Short-term mucosal disruption enables colibactin-producing E. coli to cause long-term perturbation of colonic homeostasis.
Harnack, C. and Berger, H. and Liu, L. and Mollenkopf, H.J. and Strowig, T. and Sigal, M.
Gut Microbes 15 (1): 2233689. 10 July 2023

Synchrones Auftreten eines Adenokarzinoms und eines Non-Hodgkin B-Zell-Lymphoms bei einem Patienten mit einem variablen Immundefektsyndrom (CVID) [When malignancy hits twice - synchronous gastric carcinoma and non-Hodgkin-B-cell lymphoma in a patient with common variable immunodeficiency].
Krick, D. and Hauptmann, K. and Penndorf, V. and Tacke, F. and Krüger, R. and von Bernuth, H. and Sigal, M.
Zeitschrift fur Gastroenterologie 61 (7): 827-831. July 2023

Biliary microbial patterns in primary sclerosing cholangitis are linked to poorer transplant-free survival.
Özdirik, B. and Scherf, M. and Brumercek, A. and Nicklaus, J.M. and Kruis, T. and Haber, P.K. and Pratschke, J. and Tacke, F. and Sigal, M.
Hepatology Communications 7 (6): e0156. June 2023

Establishment of gastrointestinal assembloids to study the interplay between epithelial crypts and their mesenchymal niche.
Lin, M. and Hartl, K. and Heuberger, J. and Beccaceci, G. and Berger, H. and Li, H. and Liu, L. and Müllerke, S. and Conrad, T. and Heymann, F. and Woehler, A. and Tacke, F. and Rajewsky, N. and Sigal, M.
Nature Communications 14 (1): 3025. 25 May 2023

Unwelcome guests – the role of gland-associated Helicobacter pylori infection in gastric carcinogenesis.
Beccaceci, G. and Sigal, M.
Frontiers in Oncology 13 : 1171003. 21 April 2023


R-spondin-YAP axis promotes gastric oxyntic gland regeneration and Helicobacter pylori-associated metaplasia in mice.
Fischer, A.S. and Müllerke, S. and Arnold, A. and Heuberger, J. and Berger, H. and Lin, M. and Mollenkopf, H.J. and Wizenty, J. and Horst, D. and Tacke, F. and Sigal, M.
Journal of Clinical Investigation 132 (21): e151363. 1 November 2022

Gastric stem cells promote inflammation and gland remodeling in response to Helicobacter pylori via Rspo3-Lgr4 axis.
Wizenty, J. and Müllerke, S. and Kolesnichenko, M. and Heuberger, J. and Lin, M. and Fischer, A.S. and Mollenkopf, H.J. and Berger, H. and Tacke, F. and Sigal, M.
EMBO Journal 41 (13): e109996. 4 July 2022

Soluble urokinase plasminogen activator receptor levels are associated with severity of fibrosis in patients with primary sclerosing cholangitis.
Özdirik, B. and Maibier, M. and Scherf, M. and Nicklaus, J.M. and Frohme, J. and Puengel, T. and Meyer Zum Büschenfelde, D. and Tacke, F. and Mueller, T. and Sigal, M.
Journal of Clinical Medicine 11 (9): 2479. 28 April 2022

Epigenetic modifier balances Mapk and Wnt signalling in differentiation of goblet and Paneth cells.
Grinat, J. and Kosel, F. and Goveas, N. and Kranz, A. and Alexopoulou, D. and Rajewsky, K. and Sigal, M. and Stewart, A.F. and Heuberger, J.
Life Science Alliance 5 (4): e202101187. April 2022

Stem cells, helicobacter pylori and mutational landscape: utility of preclinical models to understand carcinogenesis and to direct management of gastric cancer.
Liabeuf, D. and Oshima, M. and Stange, D.E. and Sigal, M.
Gastroenterology 162 (4): 1067-1087. April 2022

BMP feed-forward loop promotes terminal differentiation in gastric glands and is interrupted by H. pylori-driven inflammation.
Kapalczynska, M. and Lin, M. and Maertzdorf, J. and Heuberger, J. and Muellerke, S. and Zuo, X. and Vidal, R. and Shureiqi, I. and Fischer, A.S. and Sauer, S. and Berger, H. and Kidess, E. and Mollenkopf, H.J. and Tacke, F. and Meyer, T.F. and Sigal, M.
Nature Communications 13 (1): 1577. 24 March 2022

S100A4 is a strong negative prognostic marker and potential therapeutic target in adenocarcinoma of the stomach and esophagus.
Treese, C. and Hartl, K. and Pötzsch, M. and Dahlmann, M. and von Winterfeld, M. and Berg, E. and Hummel, M. and Timm, L. and Rau, B. and Walther, W. and Daum, S. and Kobelt, D. and Stein, U.
Cells 11 (6): 1056. 21 March 2022

Helicobacter pylori - neue Aspekte kommender Leitlinien [Helicobacter pylori - new aspects of forthcoming guidelines].
Schulz, C. and Fischbach, W. and Sigal, M. and Schütte, K. and Suerbaum, S. and Malfertheiner, P.
Internist 63 (4): 367-371. 1 March 2022


Elevated Flt3L predicts long-term survival in patients with high-grade gastroenteropancreatic neuroendocrine neoplasms.
Detjen, K.M. and Otto, R. and Giesecke, Y. and Geisler, L. and Riemer, P. and Jann, H. and Grötzinger, C. and Sers, C. and Pascher, A. and Lüdde, T. and Leser, U. and Wiedenmann, B. and Sigal, M. and Tacke, F. and Roderburg, C. and Hammerich, L.
Cancers 13 (17): 4463. 1 September 2021

The role of microbiota in primary sclerosing cholangitis and related biliary malignancies.
Özdirik, B. and Müller, T. and Wree, A. and Tacke, F. and Sigal, M.
International Journal of Molecular Sciences 22 (13): 6975. 1 July 2021

High Yap and Mll1 promote a persistent regenerative cell state induced by Notch signaling and loss of p53.
Heuberger, J. and Grinat, J. and Kosel, F. and Liu, L. and Kunz, S. and Vidal, R.O. and Keil, M. and Haybaeck, J. and Robine, S. and Louvard, D. and Regenbrecht, C. and Sporbert, A. and Sauer, S. and von Eyss, B. and Sigal, M. and Birchmeier, W.
Proceedings of the National Academy of Sciences of the United States of America 118 (22): e2019699118. 1 June 2021

Health workforce response to Covid-19: What pandemic preparedness planning and action at the federal and state levels in Germany? Germany's health workforce responses to Covid-19.
Köppen, J. and Hartl, K. and Maier, C.B.
International Journal of Health Planning and Management 36 (S1): 71-91. May 2021

Epithelial response to IFN-γ promotes SARS-CoV-2 infection.
Heuberger, J. and Trimpert, J. and Vladimirova, D. and Goosmann, C. and Lin, M. and Schmuck, R. and Mollenkopf, H.J. and Brinkmann, V. and Tacke, F. and Osterrieder, N. and Sigal, M.
EMBO Molecular Medicine 13 (4): e13191. 9 April 2021

Defence and adaptation mechanisms of the intestinal epithelium upon infection.
Iftekhar, A. and Sigal, M.
International Journal of Medical Microbiology 311 (3): 151486. April 2021

Genomic aberrations after short-term exposure to colibactin-producing E. coli transform primary colon epithelial cells.
Iftekhar, A. and Berger, H. and Bouznad, N. and Heuberger, J. and Boccellato, F. and Dobrindt, U. and Hermeking, H. and Sigal, M. and Meyer, T.F.
Nature Communications 12 (1): 1003. 12 February 2021

Wie das Immunsystem SARS-CoV-2 den Weg ebnet [How the immune system paves the way for SARS-CoV-2].
Sigal, M.
Hygiene und Medizin 46 (3): 22-23. 2021


Microbe-driven genotoxicity in gastrointestinal carcinogenesis.
Hartl, K. and Sigal, M.
International Journal of Molecular Sciences 21 (20): 7439. 2 October 2020

Responses of gastric epithelial stem cells and their niche to Helicobacter pylori infection.
Wizenty, J. and Tacke, F. and Sigal, M.
Annals of Translational Medicine 8 (8): 568. April 2020


R-spondin 3 promotes stem cell recovery and epithelial regeneration in the colon.
Harnack, C. and Berger, H. and Antanaviciute, A. and Vidal, R. and Sauer, S. and Simmons, A. and Meyer, T.F. and Sigal, M.
Nature Communications 10 (1): 4368. 25 September 2019

R-spondin-3 induces secretory, antimicrobial Lgr5(+) cells in the stomach.
Sigal, M. and Del Mar Reinés, M. and Müllerke, S. and Fischer, C. and Kapalczynska, M. and Berger, H. and Bakker, E.R.M. and Mollenkopf, H.J. and Rothenberg, M.E. and Wiedenmann, B. and Sauer, S. and Meyer, T.F.
Nature Cell Biology 21 (7): 812-823. July 2019

The role of Wnt and R-spondin in the stomach during health and disease.
Fischer, A.S. and Sigal, M.
Biomedicines 7 (2): 44. 19 June 2019


Helicobacter pylori depletes cholesterol in gastric glands to prevent interferon gamma signaling and escape the inflammatory response.
Morey, P. and Pfannkuch, L. and Pang, E. and Boccellato, F. and Sigal, M. and Imai-Matsushima, A. and Dyer, V. and Koch, M. and Mollenkopf, H.J. and Schlaermann, P. and Meyer, T.F.
Gastroenterology 154 (5): 1391-1404. April 2018

Microbiome and diseases: colorectal cancer.
Iftekhar, A. and Sperlich, A. and Janssen, K.P. and Sigal, M.
In: The Gut Microbiome in Health and Disease. Springer, Cham, 231-249. ISBN 978-3-319-90544-0 2018


Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis.
Sigal, M. and Logan, C.Y. and Kapalczynska, M. and Mollenkopf, H.J. and Berger, H. and Wiedenmann, B. and Nusse, R. and Amieva, M.R. and Meyer, T.F.
Nature 548 (7668): 451-455. 24 August 2017


Coevolution between the human microbiota and the epithelial immune system.
Sigal, M. and Meyer, T.F.
Digestive Diseases 34 (3): 190-193. March 2016


Quantitative imaging of gut microbiota spatial organization.
Earle, K.A. and Billings, G. and Sigal, M. and Lichtman, J.S. and Hansson, G.C. and Elias, J.E. and Amieva, M.R. and Huang, K.C. and Sonnenburg, J.L.
Cell Host & Microbe 18 (4): 478-488. 14 October 2015

Chemodetection and destruction of host urea allows Helicobacter pylori to locate the epithelium.
Huang, J.Y. and Sweeney Goers, E. and Sigal, M. and Zhang, H.C. and Remington, S.J. and Cantrell, M.A. and Kuo, C.J. and Guillemin, K. and Amieva, M.R.
Cell Host & Microbe 18 (2): 147-156. 12 August 2015

Helicobacter pylori activates and expands Lgr5(+) stem cells through direct colonization of the gastric glands.
Sigal, M. and Rothenberg, M.E. and Logan, C.Y. and Lee, J.Y. and Honaker, R.W. and Cooper, R.L. and Passarelli, B. and Camorlinga, M. and Bouley, D.M. and Alvarez, G. and Nusse, R. and Torres, J. and Amieva, M.R.
Gastroenterology 148 (7): 1392-1404. June 2015


Hepatoprotection in bile duct ligated mice mediated by darbepoetin-α is not caused by changes in hepatobiliary transporter expression.
Eipel, C. and Menschikow, E. and Sigal, M. and Kuhla, A. and Abshagen, K. and Vollmar, B.
International Journal of Clinical and Experimental Pathology 6 (1): 80-90. 1 January 2013


Neuroendokrine Neoplasien des gastroenteropankreatischen Systems [Gastroenteropancreatic neuro-endocrine neoplasms].
Sigal, M. and Pape, F. and Wiedenmann, B.
Therapeutische Umschau 69 (10): 591-596. October 2012


Darbepoetin-α inhibits the perpetuation of necro-inflammation and delays the progression of cholestatic fibrosis in mice.
Sigal, M. and Siebert, N. and Zechner, D. and Menschikow, E. and Abshagen, K. and Vollmar, B. and Eipel, C.
Laboratory Investigation 90 (10): 1447-1456. October 2010

Darbepoetin-α verringert die Nekroinflammation und mildert die cholestatische Fibrose in Mäusen [Darbepoetin-alpha inhibits the perpetuation of necro-inflammation and attenuates cholestatic fibrosis in mice].
Sigal, M. and Siebert, N. and Abshagen, K. and Vollmar, B. and Eipel, C.
In: Chirurgisches Forum und DGAV Forum 2010. Deutsche Gesellschaft für Chirurgie, 39 . Springer, Berlin, Heidelberg, 203-205. ISBN 978-3-642-12191-3 2010

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