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iPSC-derived reactive astrocytes from patients with multiple-sclerosis protect cocultured neurons in inflammatory conditions.
Kerkering, J. and Muinjonov, B. and Rosiewicz, K.S. and Diecke, S. and Biese, C. and Schiweck, J. and Chien, C. and Zocholl, D. and Conrad, T. and Paul, F. and Alisch, M. and Siffrin, V.
Journal of Clinical Investigation 133 (13): e164637. 3 July 2023

Inflammatory cytokines associated with multiple sclerosis directly induce alterations of neuronal cytoarchitecture in human neurons.
Meyer-Arndt, L. and Kerkering, J. and Kuehl, T. and Gil Infante, A. and Paul, F. and Rosiewicz, K.S. and Siffrin, V. and Alisch, M.
Journal of Neuroimmune Pharmacology 18 (1-2): 145-159. June 2023

Mepolizumab as an effective treatment in a case of hypophysitis in eosinophilic granulomatosis with polyangiitis.
Chen, J. and Alexander, T. and Walter-Rittel, T. and Ziagaki, A. and Siffrin, V.
Therapeutic Advances in Neurological Disorders 16 : 17562864231182519. 2023

Pentafluorosulfanyl (SF(5)) as a superior (19)F magnetic resonance reporter group: signal detection and biological activity of teriflunomide derivatives.
Prinz, C. and Starke, L. and Ramspoth, T.F. and Kerkering, J. and Martos Riaño, V. and Paul, J. and Neuenschwander, M. and Oder, A. and Radetzki, S. and Adelhoefer, S. and Ramos Delgado, P. and Aravina, M. and Millward, J.M. and Fillmer, A. and Paul, F. and Siffrin, V. and von Kries, J.P. and Niendorf, T. and Nazaré, M. and Waiczies, S.
ACS Sensors 6 (11): 3948–3956. 26 November 2021

Lymphocyte access to lymphoma is impaired by high endothelial venule regression.
Menzel, L. and Zschummel, M. and Crowley, T. and Franke, V. and Grau, M. and Ulbricht, C. and Hauser, A. and Siffrin, V. and Bajénoff, M. and Acton, S.E. and Akalin, A. and Lenz, G. and Willimsky, G. and Höpken, U.E. and Rehm, A.
Cell Reports 37 (4): 109878. 26 October 2021

Identification of the gliogenic state of human neural stem cells to optimize in vitro astrocyte differentiation.
Alisch, M. and Kerkering, J. and Crowley, T. and Rosiewicz, K. and Paul, F. and Siffrin, V.
Journal of Neuroscience Methods 361 : 109284. 1 September 2021

Epigallocatechin gallate in relapsing-remitting multiple sclerosis: a randomized, placebo-controlled trial.
Bellmann-Strobl, J. and Paul, F. and Wuerfel, J. and Dörr, J. and Infante-Duarte, C. and Heidrich, E. and Körtgen, B. and Brandt, A. and Pfüller, C. and Radbruch, H. and Rust, R. and Siffrin, V. and Aktas, O. and Heesen, C. and Faiss, J. and Hoffmann, F. and Lorenz, M. and Zimmermann, B. and Groppa, S. and Wernecke, K.D. and Zipp, F.
Neurology Neuroimmunology & Neuroinflammation 8 (3): e981. May 2021

Neutrophil gelatinase-associated lipocalin protects from ANCA-induced GN by inhibiting T(H)17 immunity.
Schreiber, A. and Rousselle, A. and Klocke, J. and Bachmann, S. and Popovic, S. and Bontscho, J. and Schmidt-Ott, K.M. and Siffrin, V. and Jerke, U. and Ashraf, M.I. and Panzer, U. and Kettritz, R.
Journal of the American Society of Nephrology 31 (7): 1569-1584. July 2020

Comparison of RNA isolation procedures for analysis of adult murine brain and spinal cord astrocytes.
Rosiewicz, K.S. and Crowley, T. and Saher, G. and Kerkering, J. and Alisch, M. and Siffrin, V.
Journal of Neuroscience Methods 333 : 108545. 1 March 2020

Disease modification in multiple sclerosis by flupirtine - results of a randomized placebo controlled phase II trial.
Dörr, J. and Wernecke, K.D. and Würfel, J. and Bellmann-Strobl, J. and Siffrin, V. and Sättler, M.B. and Simons, M. and Linsa, A. and Tumani, H. and Paul, F.
Frontiers in Neurology 9 : 842. October 2018

CCR7 on CD4(+) T cells plays a crucial role in the induction of experimental autoimmune encephalomyelitis.
Belikan, P. and Bühler, U. and Wolf, C. and Pramanik, G.K. and Gollan, R. and Zipp, F. and Siffrin, V.
Journal of Immunology 200 (8): 2554-2562. 15 April 2018

Phenotype of antigen unexperienced T(H) cells in the inflamed central nervous system in experimental autoimmune encephalomyelitis.
Franck, S. and Paterka, M. and Birkenstock, J. and Zipp, F. and Siffrin, V. and Witsch, E.
Journal of Neuroimmune Pharmacology 12 (2): 305-313. June 2017

Role of IL-17-producing lymphocytes in severity of multiple sclerosis upon natalizumab treatment.
Bühler, U. and Fleischer, V. and Luessi, F. and Rezk, A. and Belikan, P. and Graetz, C. and Gollan, R. and Wolf, C. and Lutz, J. and Bar-Or, A. and Siffrin, V. and Zipp, F.
Multiple Sclerosis Journal 23 (4): 567-576. 1 April 2017

Dendritic cells tip the balance towards induction of regulatory T cells upon priming in experimental autoimmune encephalomyelitis.
Paterka, M. and Voss, J.O. and Werr, J. and Reuter, E. and Franck, S. and Leuenberger, T. and Herz, J. and Radbruch, H. and Bopp, T. and Siffrin, V. and Zipp, F.
Journal of Autoimmunity 76 : 108-114. January 2017

PML risk stratification using anti-JCV antibody index and L-selectin.
Schwab, N. and Schneider-Hohendorf, T. and Pignolet, B. and Spadaro, M. and Görlich, D. and Meinl, I. and Windhagen, S. and Tackenberg, B. and Breuer, J. and Cantó, E. and Kümpfel, T. and Hohlfeld, R. and Siffrin, V. and Luessi, F. and Posevitz-Fejfár, A. and Montalban, X. and Meuth, S.G. and Zipp, F. and Gold, R. and Du Pasquier, R.A. and Kleinschnitz, C. and Jacobi, A. and Comabella, M. and Bertolotto, A. and Brassat, D. and Wiendl, H.
Multiple Sclerosis Journal 22 (8): 1048-1060. July 2016

Flow cytometric analysis of T cell/monocyte ratio in clinically isolated syndrome identifies patients at risk of rapid disease progression.
Nemecek, A. and Zimmermann, H. and Rübenthaler, J. and Fleischer, V. and Paterka, M. and Luessi, F. and Müller-Forell, W. and Zipp, F. and Siffrin, V.
Multiple Sclerosis Journal 22 (4): 483-493. April 2016

In vivo and in vitro effects of multiple sclerosis immunomodulatory therapeutics on glutamatergic excitotoxicity.
Luchtman, D. and Gollan, R. and Ellwardt, E. and Birkenstock, J. and Robohm, K. and Siffrin, V. and Zipp, F.
Journal of Neurochemistry 136 (5): 971-980. March 2016

Gatekeeper role of brain antigen-presenting CD11c(+) cells in neuroinflammation.
Paterka, M. and Siffrin, V. and Voss, J.O. and Werr, J. and Hoppmann, N. and Gollan, R. and Belikan, P. and Bruttger, J. and Birkenstock, J. and Jung, S. and Esplugues, E. and Yogev, N. and Flavell, R.A. and Bopp, T. and Zipp, F.
EMBO Journal 35 (1): 89-101. 4 January 2016

Role of sortilin in models of autoimmune neuroinflammation.
Reuter, E. and Weber, J. and Paterka, M. and Ploen, R. and Breiderhoff, T. and van Horssen, J. and Willnow, T.E. and Siffrin, V. and Zipp, F.
Journal of Immunology 195 (12): 5762-5769. 15 December 2015

FRET based ratiometric Ca(2+) imaging to investigate immune-mediated neuronal and axonal damage processes in experimental autoimmune encephalomyelitis.
Siffrin, V. and Birkenstock, J. and Luchtmann, D.W. and Gollan, R. and Baumgart, J. and Niesner, R.A. and Griesbeck, O. and Zipp, F.
Journal of Neuroscience Methods 249 : 8-15. 15 July 2015

New candidates for CD4 T cell pathogenicity in experimental neuroinflammation and multiple sclerosis.
Hoppmann, N. and Graetz, C. and Paterka, M. and Poisa-Beiro, L. and Larochelle, C. and Hasan, M. and Lill, C.M. and Zipp, F. and Siffrin, V.
Brain 138 (Pt 4): 902-917. April 2015

Cross-recognition of a myelin peptide by CD8(+) T cells in the CNS is not sufficient to promote neuronal damage.
Reuter, E. and Gollan, R. and Grohmann, N. and Paterka, M. and Salmon, H. and Birkenstock, J. and Richers, S. and Leuenberger, T. and Brandt, A.U. and Kuhlmann, T. and Zipp, F. and Siffrin, V.
Journal of Neuroscience 35 (12): 4837-4850. 25 March 2015

MHCII-independent CD4(+) T cells protect injured CNS neurons via IL-4.
Walsh, J.T. and Hendrix, S. and Boato, F. and Smirnov, I. and Zheng, J. and Lukens, J.R. and Gadani, S. and Hechler, D. and Gölz, G. and Rosenberger, K. and Kammertöns, T. and Vogt, J. and Vogelaar, C. and Siffrin, V. and Radjavi, A. and Fernandez-Castaneda, A. and Gaultier, A. and Gold, R. and Kanneganti, T.D. and Nitsch, R. and Zipp, F. and Kipnis, J.
Journal of Clinical Investigation 125 (2): 699-714. 2 February 2015

The impact of isolated lesions on white-matter fiber tracts in multiple sclerosis patients.
Droby, A. and Fleischer, V. and Carnini, M. and Zimmermann, H. and Siffrin, V. and Gawehn, J. and Erb, M. and Hildebrandt, A. and Baier, B. and Zipp, F.
NeuroImage: Clinical 8 : 110-116. 2015

Cardiotoxicity of mitoxantrone treatment in a german cohort of 639 multiple sclerosis patients.
Fleischer, V. and Salmen, A. and Kollar, S. and Weyer, V. and Siffrin, V. and Chan, A. and Zipp, F. and Luessi, F.
Journal of Clinical Neurology 10 (4): 289-295. October 2014

Modulation of dendritic cell immunobiology via inhibition of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase.
Leuenberger, T. and Pfueller, C.F. and Luessi, F. and Bendix, I. and Paterka, M. and Prozorovski, T. and Treue, D. and Luenstedt, S. and Herz, J. and Siffrin, V. and Infante-Duarte, C. and Zipp, F. and Waiczies, S.
PLoS ONE 9 (7): e100871. 11 July 2014

Experimental applications of TNF-reporter mice with far-red fluorescent label.
Shebzukhov, Y.V. and Kuchmiy, A.A. and Kruglov, A.A. and Zipp, F. and Siffrin, V. and Nedospasov, S.A.
Methods in Molecular Biology 1155 : 151-162. 10 April 2014

How to treat tumefactive demyelinating disease?
Siffrin, V. and Müller-Forell, W. and von Pein, H. and Zipp, F.
Multiple Sclerosis Journal 20 (5): 631-633. April 2014

Membrane-type 1 metalloproteinase is upregulated in microglia/brain macrophages in neurodegenerative and neuroinflammatory diseases.
Langenfurth, A. and Rinnenthal, J.L. and Vinnakota, K. and Prinz, V. and Carlo, A.S. and Stadelmann, C. and Siffrin, V. and Peaschke, S. and Endres, M. and Heppner, F. and Glass, R. and Wolf, S.A. and Kettenmann, H.
Journal of Neuroscience Research 92 (3): 275-286. March 2014

Microglial activation milieu controls regulatory T cell responses.
Ebner, F. and Brandt, C. and Thiele, P. and Richter, D. and Schliesser, U. and Siffrin, V. and Schueler, J. and Stubbe, T. and Ellinghaus, A. and Meisel, C. and Sawitzki, B. and Nitsch, R.
Journal of Immunology 191 (11): 5594-5602. 1 December 2013

The role of CD8(+) T cells and their local interaction with CD4(+) T cells in myelin oligodendrocyte glycoprotein(35-55)-induced experimental autoimmune encephalomyelitis.
Leuenberger, T. and Paterka, M. and Reuter, E. and Herz, J. and Niesner, R.A. and Radbruch, H. and Bopp, T. and Zipp, F. and Siffrin, V.
Journal of Immunology 191 (10): 4960-4968. 15 November 2013

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.

Nature Genetics 45 (11): 1353-1360. November 2013

Parallelized TCSPC for dynamic intravital fluorescence lifetime imaging: quantifying neuronal dysfunction in neuroinflammation.
Rinnenthal, J.L. and Börnchen, C. and Radbruch, H. and Andresen, V. and Mossakowski, A. and Siffrin, V. and Seelemann, T. and Spiecker, H. and Moll, I. and Herz, J. and Hauser, A.E. and Zipp, F. and Behne, M.J. and Niesner, R.
PLoS ONE 8 (4): e60100. 16 April 2013

Modulation of dendritic cell properties by laquinimod as a mechanism for modulating multiple sclerosis.
Jolivel, V. and Luessi, F. and Masri, J. and Kraus, S.H.P. and Hubo, M. and Poisa-Beiro, L. and Klebow, S. and Paterka, M. and Yogev, N. and Tumani, H. and Furlan, R. and Siffrin, V. and Jonuleit, H. and Zipp, F. and Waisman, A.
Brain 136 (4): 1048-1066. 1 April 2013

Two-photon imaging of immune cells in neural tissue.
Niesner, R. and Siffrin, V. and Zipp, F.
Cold Spring Harbor Protocols 2013 (3): 224-230. 1 March 2013

BLBP-expression in astrocytes during experimental demyelination and in human multiple sclerosis lesions.
Kipp, M. and Gingele, S. and Pott, F. and Clarner, T. and van der Valk, P. and Denecke, B. and Gan, L. and Siffrin, V. and Zipp, F. and Dreher, W. and Baumgartner, W. and Pfeifenbring, S. and Godbout, R. and Amor, S. and Beyer, C.
Brain, Behavior and Immunity 25 (8): 1554-1568. November 2011

In vivo imaging of lymphocytes in the CNS reveals different behaviour of naive T cells in health and autoimmunity.
Herz, J. and Paterka, M. and Niesner, R.A. and Brandt, A.U. and Siffrin, V. and Leuenberger, T. and Birkenstock, J. and Mossakowski, A. and Glumm, R. and Zipp, F. and Radbruch, H.
Journal of Neuroinflammation 8 (1): 131. 6 October 2011

In vivo imaging of partially reversible th17 cell-induced neuronal dysfunction in the course of encephalomyelitis.
Siffrin, V. and Radbruch, H. and Glumm, R. and Niesner, R. and Paterka, M. and Herz, J. and Leuenberger, T. and Lehmann, S.M. and Luenstedt, S. and Rinnenthal, J.L. and Laube, G. and Luche, H. and Lehnardt, S. and Fehling, H.J. and Griesbeck, O. and Zipp, F.
Immunity 33 (3): 424-436. 24 September 2010

MAPK3 deficiency drives autoimmunity via dendritic cell arming.
Bendix, I. and Pfueller, C.F. and Leuenberger, T. and Glezeva, N. and Siffrin, V. and Mueller, Y. and Prozorovski, T. and Hansen, W. and Schulze-Topphoff, U. and Loddenkemper, C. and Zipp, F. and Waiczies, S.
European Journal of Immunology 40 (5): 1486-1495. May 2010

Expanding two-photon intravital microscopy to the infrared by means of optical parametric oscillator.
Herz, J. and Siffrin, V. and Hauser, A.E. and Brandt, A.U. and Leuenberger, T. and Radbruch, H. and Zipp, F. and Niesner, R.A.
Biophysical Journal 98 (4): 715-723. 17 February 2010

Cytotoxic CD8+ T cell-neuron interactions: perforin-dependent electrical silencing precedes but is not causally linked to neuronal cell death.
Meuth, S.G. and Herrmann, A.M. and Simon, O.J. and Siffrin, V. and Melzer, N. and Bittner, S. and Meuth, P. and Langer, H.F. and Hallermann, S. and Boldakowa, N. and Herz, J. and Munsch, T. and Landgraf, P. and Aktas, O. and Heckmann, M. and Lessmann, V. and Budde, T. and Kieseier, B.C. and Zipp, F. and Wiendl, H.
Journal of Neuroscience 29 (49): 15397-15409. 9 December 2009

Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous system.
Schulze-Topphoff, U. and Prat, A. and Prozorovski, T. and Siffrin, V. and Paterka, M. and Herz, J. and Bendix, I. and Ifergan, I. and Schadock, I. and Mori, M.A. and Van Horssen, J. and Schroeter, F. and Smorodchenko, A. and Han, M.H. and Bader, M. and Steinman, L. and Aktas, O. and Zipp, F.
Nature Medicine 15 (7): 788-793. July 2009

Differential immune cell dynamics in the CNS cause CD4+ T cell compartmentalization.
Siffrin, V. and Brandt, A.U. and Radbruch, H. and Herz, J. and Boldakowa, N. and Leuenberger, T. and Werr, J. and Hahner, A. and Schulze-Topphoff, U. and Nitsch, R. and Zipp, F.
Brain 132 (5): 1247-1258. May 2009

Lipopolysaccharide injection induces relapses of experimental autoimmune encephalomyelitis in nontransgenic mice via bystander activation of autoreactive CD4+ cells.
Nogai, A. and Siffrin, V. and Bonhagen, K. and Pfueller, C.F. and Hohnstein, T. and Volkmer-Engert, R. and Brueck, W. and Stadelmann, C. and Kamradt, T.
Journal of Immunology 175 (2): 959-966. 15 July 2005

Conference or Workshop Item

A new light source for multimodal multiphoton microscopy including CARS.
Rimke, I. and Siffrin, V. and Niesner, R. and Leuenberger, T. and Zipp, F. and Buttnera, E. and Stibenza, G.
In: Conference on Multiphoton Microscopy in the Biomedical Sciences IX, JAN 25-27, 2009 , San Jose, CA, USA. 13 February 2009


Neurodegeneration in multiple sclerosis: novel treatment strategies.
Luessi, F. and Siffrin, V. and Zipp, F.
Expert Review of Neurotherapeutics 12 (9): 1061-1077. September 2012

Neurodegeneration in autoimmune CNS inflammation.
Herz, J. and Zipp, F. and Siffrin, V.
Experimental Neurology 225 (1): 9-17. September 2010

Multiple sclerosis - candidate mechanisms underlying CNS atrophy.
Siffrin, V. and Vogt, J. and Radbruch, H. and Nitsch, R. and Zipp, F.
Trends in Neurosciences 33 (4): 202-210. April 2010

New insights into adaptive immunity in chronic neuroinflammation.
Siffrin, V. and Brandt, A.U. and Herz, J. and Zipp, F.
Advances in Immunology 96 : 1-40. 2007


Reevaluating the relevance of F-FDG PET findings for diagnosis of neurosarcoidosis: a case series.
Chen, J. and Metzger, G. and Furth, C. and Bohner, G. and Siffrin, V.
Neurological Research and Practice 6 (1): 12. 25 January 2024


Complicated monkeypox infection in a patient with multiple sclerosis and fingolimod treatment.
Müller-Jensen, L. and Kriedemann, H. and Anvari, K. and Huehnchen, P. and Siffrin, V.
Neurology 100 (14): 670-671. 4 April 2023

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